BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
131798	O=C1CCOc2cc(O[C@H](c3ccncc3)c3ccccc3F)ccc21	InChI=1S/C21H16FNO3/c22-18-4-2-1-3-16(18)21(14-7-10-23-11-8-14)26-15-5-6-17-19(24)9-12-25-20(17)13-15/h1-8,10-11,13,21H,9,12H2	IFUJWUULMZKBNU-UHFFFAOYSA-N	114905	(*R)-7-((2-Fluorophenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 1a	HLA-DR4 protein			 1000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114905&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			91899742	252664368							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131799	O=C1CCOc2cc(O[C@@H](c3ccncc3)c3ccccc3F)ccc21	InChI=1S/C21H16FNO3/c22-18-4-2-1-3-16(18)21(14-7-10-23-11-8-14)26-15-5-6-17-19(24)9-12-25-20(17)13-15/h1-8,10-11,13,21H,9,12H2	IFUJWUULMZKBNU-UHFFFAOYSA-N	114907	(*S)-7-((2-Fluorophenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 1b	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114907&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3894771	252664370							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131800	O=C1CCOc2cc(OC(c3ccncc3)c3cccc(F)c3)ccc21	InChI=1S/C21H16FNO3/c22-16-3-1-2-15(12-16)21(14-6-9-23-10-7-14)26-17-4-5-18-19(24)8-11-25-20(18)13-17/h1-7,9-10,12-13,21H,8,11H2	GWTNQIXJFUIGNF-UHFFFAOYSA-N	114911	US12516038, Example 2	HLA-DR4 protein			 1000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114911&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3810088	252664373							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131801	O=C1CCOc2cc(O[C@H](c3ccncc3)c3cccc(F)c3)ccc21	InChI=1S/C21H16FNO3/c22-16-3-1-2-15(12-16)21(14-6-9-23-10-7-14)26-17-4-5-18-19(24)8-11-25-20(18)13-17/h1-7,9-10,12-13,21H,8,11H2	GWTNQIXJFUIGNF-UHFFFAOYSA-N	114917	(*R)-7-((3-Fluorophenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 2a	HLA-DR4 protein			 1600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114917&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			898570	252664379							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131802	O=C1CCOc2cc(O[C@@H](c3ccncc3)c3cccc(F)c3)ccc21	InChI=1S/C21H16FNO3/c22-16-3-1-2-15(12-16)21(14-6-9-23-10-7-14)26-17-4-5-18-19(24)8-11-25-20(18)13-17/h1-7,9-10,12-13,21H,8,11H2	GWTNQIXJFUIGNF-UHFFFAOYSA-N	114922	(*S)-7-((3-Fluorophenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 2b	HLA-DR4 protein			 1800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114922&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			91899743	252664384							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131803	O=C1CCOc2cc(OC(c3ccncc3)c3ccc(F)cc3)ccc21	InChI=1S/C21H16FNO3/c22-16-3-1-14(2-4-16)21(15-7-10-23-11-8-15)26-17-5-6-18-19(24)9-12-25-20(18)13-17/h1-8,10-11,13,21H,9,12H2	JLWIUZDXTSQHFA-UHFFFAOYSA-N	114923	US12516038, Example 3	HLA-DR4 protein			 990							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114923&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			1122457	252664385							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131804	O=C1CCOc2cc(O[C@@H](c3ccncc3)c3ccc(F)cc3)ccc21	InChI=1S/C21H16FNO3/c22-16-3-1-14(2-4-16)21(15-7-10-23-11-8-15)26-17-5-6-18-19(24)9-12-25-20(18)13-17/h1-8,10-11,13,21H,9,12H2	JLWIUZDXTSQHFA-UHFFFAOYSA-N	114933	(*R)-7-((4-Fluorophenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 3a	HLA-DR4 protein			 1600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114933&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5333851	252664395							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131805	O=C1CCOc2cc(O[C@H](c3ccncc3)c3ccc(F)cc3)ccc21	InChI=1S/C21H16FNO3/c22-16-3-1-14(2-4-16)21(15-7-10-23-11-8-15)26-17-5-6-18-19(24)9-12-25-20(18)13-17/h1-8,10-11,13,21H,9,12H2	JLWIUZDXTSQHFA-UHFFFAOYSA-N	114934	(*S)-7-((4-Fluorophenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 3b	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114934&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2417513	252664396							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131806	COc1ccc(COc2cccc([C@H](Oc3ccc4c(c3)OCCC4=O)c3ccncc3)c2)cc1	InChI=1S/C29H25NO5/c1-32-23-7-5-20(6-8-23)19-34-24-4-2-3-22(17-24)29(21-11-14-30-15-12-21)35-25-9-10-26-27(31)13-16-33-28(26)18-25/h2-12,14-15,17-18,29H,13,16,19H2,1H3	HXNWWCYPQJNTJL-UHFFFAOYSA-N	114939	(*R)-7-((3-((4-Methoxybenzyl)oxy)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 4a	HLA-DR4 protein			 6900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114939&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			220838	252664401							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131807	COc1ccc(COc2cccc([C@@H](Oc3ccc4c(c3)OCCC4=O)c3ccncc3)c2)cc1	InChI=1S/C29H25NO5/c1-32-23-7-5-20(6-8-23)19-34-24-4-2-3-22(17-24)29(21-11-14-30-15-12-21)35-25-9-10-26-27(31)13-16-33-28(26)18-25/h2-12,14-15,17-18,29H,13,16,19H2,1H3	HXNWWCYPQJNTJL-UHFFFAOYSA-N	114973	(*S)-7-((3-((4-Methoxybenzyl)oxy)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 4b	HLA-DR4 protein			 7900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114973&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2148477	252664435							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131808	O=C1CCOc2cc(O[C@H](c3ccncc3)c3cccc(O)c3)ccc21	InChI=1S/C21H17NO4/c23-16-3-1-2-15(12-16)21(14-6-9-22-10-7-14)26-17-4-5-18-19(24)8-11-25-20(18)13-17/h1-7,9-10,12-13,21,23H,8,11H2	LKSVHTGEVGDLRD-UHFFFAOYSA-N	114976	US12516038, Example 5a	HLA-DR4 protein			 14000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114976&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			864377	252664438							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131809	O=C1CCOc2cc(O[C@@H](c3ccncc3)c3cccc(O)c3)ccc21	InChI=1S/C21H17NO4/c23-16-3-1-2-15(12-16)21(14-6-9-22-10-7-14)26-17-4-5-18-19(24)8-11-25-20(18)13-17/h1-7,9-10,12-13,21,23H,8,11H2	LKSVHTGEVGDLRD-UHFFFAOYSA-N	114977	US12516038, Example 5b	HLA-DR4 protein			 14000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114977&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			9549684	252664439							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131810	O=C1CCOc2cc(OC(c3ccncc3)c3ccccn3)ccc21	InChI=1S/C20H16N2O3/c23-18-8-12-24-19-13-15(4-5-16(18)19)25-20(14-6-10-21-11-7-14)17-3-1-2-9-22-17/h1-7,9-11,13,20H,8,12H2	PKPQRNNOIZHZBG-UHFFFAOYSA-N	114978	US12516038, Example 6	HLA-DR4 protein			 1800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114978&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5346031	252664440							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131811	N#Cc1ccccc1[C@H](Oc1ccc2c(c1)OCCC2=O)c1ccncc1	InChI=1S/C22H16N2O3/c23-14-16-3-1-2-4-18(16)22(15-7-10-24-11-8-15)27-17-5-6-19-20(25)9-12-26-21(19)13-17/h1-8,10-11,13,22H,9,12H2	MCNKNDMMLLBXHB-UHFFFAOYSA-N	114979	(*R)-2-(((4-Oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzonitrile::US12516038, Example 7a	HLA-DR4 protein			 690							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114979&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			1870209	252664441							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131812	N#Cc1ccccc1[C@@H](Oc1ccc2c(c1)OCCC2=O)c1ccncc1	InChI=1S/C22H16N2O3/c23-14-16-3-1-2-4-18(16)22(15-7-10-24-11-8-15)27-17-5-6-19-20(25)9-12-26-21(19)13-17/h1-8,10-11,13,22H,9,12H2	MCNKNDMMLLBXHB-UHFFFAOYSA-N	114980	(*S)-2-(((4-Oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzonitrile::US12516038, Example 7b	HLA-DR4 protein			 960							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114980&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			1256890	252664442							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131813	NC(=O)c1ccccc1[C@H](Oc1ccc2c(c1)OCCC2=O)c1ccncc1	InChI=1S/C22H18N2O4/c23-22(26)17-4-2-1-3-16(17)21(14-7-10-24-11-8-14)28-15-5-6-18-19(25)9-12-27-20(18)13-15/h1-8,10-11,13,21H,9,12H2,(H2,23,26)	WWWWIYDLCIMXDS-UHFFFAOYSA-N	114981	(*R)-2-(((4-Oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 8a	HLA-DR4 protein			 680							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114981&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3527790	252664443							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131814	NC(=O)c1ccccc1[C@@H](Oc1ccc2c(c1)OCCC2=O)c1ccncc1	InChI=1S/C22H18N2O4/c23-22(26)17-4-2-1-3-16(17)21(14-7-10-24-11-8-14)28-15-5-6-18-19(25)9-12-27-20(18)13-15/h1-8,10-11,13,21H,9,12H2,(H2,23,26)	WWWWIYDLCIMXDS-UHFFFAOYSA-N	114982	(*S)-2-(((4-Oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 8b	HLA-DR4 protein			 820							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114982&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5782679	252664444							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131815	NC(=O)c1cccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)c1	InChI=1S/C22H18N2O4/c23-22(26)16-3-1-2-15(12-16)21(14-6-9-24-10-7-14)28-17-4-5-18-19(25)8-11-27-20(18)13-17/h1-7,9-10,12-13,21H,8,11H2,(H2,23,26)	VENGEEYHFFIUPF-UHFFFAOYSA-N	114983	(*R)-3-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 9a	HLA-DR4 protein			 920							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114983&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			730347	252664445							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131816	NC(=O)c1cccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)c1	InChI=1S/C22H18N2O4/c23-22(26)16-3-1-2-15(12-16)21(14-6-9-24-10-7-14)28-17-4-5-18-19(25)8-11-27-20(18)13-17/h1-7,9-10,12-13,21H,8,11H2,(H2,23,26)	VENGEEYHFFIUPF-UHFFFAOYSA-N	114984	(*S)-3-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 9b	HLA-DR4 protein			 980							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114984&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6873509	252664446							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131817	N#Cc1ccc(C(Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H16N2O3/c23-14-15-1-3-16(4-2-15)22(17-7-10-24-11-8-17)27-18-5-6-19-20(25)9-12-26-21(19)13-18/h1-8,10-11,13,22H,9,12H2	NIURVALSDGVASN-UHFFFAOYSA-N	114985	US12516038, Example 10	HLA-DR4 protein			 770							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114985&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			9586568	252664447							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131818	N#Cc1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H16N2O3/c23-14-15-1-3-16(4-2-15)22(17-7-10-24-11-8-17)27-18-5-6-19-20(25)9-12-26-21(19)13-18/h1-8,10-11,13,22H,9,12H2	NIURVALSDGVASN-UHFFFAOYSA-N	114987	(*R)-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzonitrile::US12516038, Example 10a	HLA-DR4 protein			 950							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114987&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			796821	252664449							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131819	N#Cc1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H16N2O3/c23-14-15-1-3-16(4-2-15)22(17-7-10-24-11-8-17)27-18-5-6-19-20(25)9-12-26-21(19)13-18/h1-8,10-11,13,22H,9,12H2	NIURVALSDGVASN-UHFFFAOYSA-N	114988	(*S)-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzonitrile::US12516038, Example 10b	HLA-DR4 protein			 910							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114988&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			744115	242053908							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131820	NC(=O)c1ccc(C(Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H18N2O4/c23-22(26)16-3-1-14(2-4-16)21(15-7-10-24-11-8-15)28-17-5-6-18-19(25)9-12-27-20(18)13-17/h1-8,10-11,13,21H,9,12H2,(H2,23,26)	MYHATWVEEJEXRI-UHFFFAOYSA-N	114989	US12516038, Example 11	HLA-DR4 protein			 650							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114989&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2951757	252664450							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131821	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H18N2O4/c23-22(26)16-3-1-14(2-4-16)21(15-7-10-24-11-8-15)28-17-5-6-18-19(25)9-12-27-20(18)13-17/h1-8,10-11,13,21H,9,12H2,(H2,23,26)	MYHATWVEEJEXRI-UHFFFAOYSA-N	114990	(*R)-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 11a	HLA-DR4 protein			 720							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114990&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5720643	252664451							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131822	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H18N2O4/c23-22(26)16-3-1-14(2-4-16)21(15-7-10-24-11-8-15)28-17-5-6-18-19(25)9-12-27-20(18)13-17/h1-8,10-11,13,21H,9,12H2,(H2,23,26)	MYHATWVEEJEXRI-UHFFFAOYSA-N	114991	(*S)-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 11b	HLA-DR4 protein			 950							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114991&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			845032	252664452							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131823	COc1ccc(C(Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H19NO4/c1-25-17-4-2-15(3-5-17)22(16-8-11-23-12-9-16)27-18-6-7-19-20(24)10-13-26-21(19)14-18/h2-9,11-12,14,22H,10,13H2,1H3	UVPPSNMYKKNVDX-UHFFFAOYSA-N	114992	US12516038, Example 12	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114992&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			9666663	252664453							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131824	COc1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H19NO4/c1-25-17-4-2-15(3-5-17)22(16-8-11-23-12-9-16)27-18-6-7-19-20(24)10-13-26-21(19)14-18/h2-9,11-12,14,22H,10,13H2,1H3	UVPPSNMYKKNVDX-UHFFFAOYSA-N	114993	(*R)-7-((4-Methoxyphenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 12a	HLA-DR4 protein			 2000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114993&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			682597	252664454							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131825	COc1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H19NO4/c1-25-17-4-2-15(3-5-17)22(16-8-11-23-12-9-16)27-18-6-7-19-20(24)10-13-26-21(19)14-18/h2-9,11-12,14,22H,10,13H2,1H3	UVPPSNMYKKNVDX-UHFFFAOYSA-N	114994	(*S)-7-((4-Methoxyphenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 12b	HLA-DR4 protein			 1700							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114994&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6878933	252664455							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131826	COc1cccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)c1	InChI=1S/C22H19NO4/c1-25-17-4-2-3-16(13-17)22(15-7-10-23-11-8-15)27-18-5-6-19-20(24)9-12-26-21(19)14-18/h2-8,10-11,13-14,22H,9,12H2,1H3	ONCKYKJDJNEWNY-UHFFFAOYSA-N	114995	(*R)-7-((3-methoxyphenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 13a	HLA-DR4 protein			 2000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114995&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6886797	252664456							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131827	COc1cccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)c1	InChI=1S/C22H19NO4/c1-25-17-4-2-3-16(13-17)22(15-7-10-23-11-8-15)27-18-5-6-19-20(24)9-12-26-21(19)14-18/h2-8,10-11,13-14,22H,9,12H2,1H3	ONCKYKJDJNEWNY-UHFFFAOYSA-N	114996	(*S)-7-((3-methoxyphenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 13b	HLA-DR4 protein			 1400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114996&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6624149	252664457							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131828	COc1ccccc1C(Oc1ccc2c(c1)OCCC2=O)c1ccncc1	InChI=1S/C22H19NO4/c1-25-20-5-3-2-4-18(20)22(15-8-11-23-12-9-15)27-16-6-7-17-19(24)10-13-26-21(17)14-16/h2-9,11-12,14,22H,10,13H2,1H3	XFJLFGPRFHHUGJ-UHFFFAOYSA-N	114997	US12516038, Example 14	HLA-DR4 protein			 2400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114997&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5568682	252664458							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131829	COc1ccccc1[C@H](Oc1ccc2c(c1)OCCC2=O)c1ccncc1	InChI=1S/C22H19NO4/c1-25-20-5-3-2-4-18(20)22(15-8-11-23-12-9-15)27-16-6-7-17-19(24)10-13-26-21(17)14-16/h2-9,11-12,14,22H,10,13H2,1H3	XFJLFGPRFHHUGJ-UHFFFAOYSA-N	114998	(*R)-7-((2-Methoxyphenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 14a	HLA-DR4 protein			 1900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114998&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5113181	252664459							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131830	COc1ccccc1[C@@H](Oc1ccc2c(c1)OCCC2=O)c1ccncc1	InChI=1S/C22H19NO4/c1-25-20-5-3-2-4-18(20)22(15-8-11-23-12-9-15)27-16-6-7-17-19(24)10-13-26-21(17)14-16/h2-9,11-12,14,22H,10,13H2,1H3	XFJLFGPRFHHUGJ-UHFFFAOYSA-N	114999	(*S)-7-((2-Methoxyphenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 14b	HLA-DR4 protein			 1900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114999&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6875563	252664460							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131831	Cc1cc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccc(C(N)=O)cc2)ccn1	InChI=1S/C23H20N2O4/c1-14-12-17(8-10-25-14)22(15-2-4-16(5-3-15)23(24)27)29-18-6-7-19-20(26)9-11-28-21(19)13-18/h2-8,10,12-13,22H,9,11H2,1H3,(H2,24,27)	IZFCQMZIJYPVEG-UHFFFAOYSA-N	115000	(*R)-4-((2-Methylpyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 15a	HLA-DR4 protein			 440							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115000&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3881988	252664461							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131832	Cc1cc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccc(C(N)=O)cc2)ccn1	InChI=1S/C23H20N2O4/c1-14-12-17(8-10-25-14)22(15-2-4-16(5-3-15)23(24)27)29-18-6-7-19-20(26)9-11-28-21(19)13-18/h2-8,10,12-13,22H,9,11H2,1H3,(H2,24,27)	IZFCQMZIJYPVEG-UHFFFAOYSA-N	115001	(*S)-4-((2-Methylpyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 15b	HLA-DR4 protein			 770							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115001&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2591914	252664462							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131833	O=C1CCOc2cc(O[C@@H](c3ccncc3)c3ccc(OCc4ccccc4)cc3)ccc21	InChI=1S/C28H23NO4/c30-26-14-17-31-27-18-24(10-11-25(26)27)33-28(22-12-15-29-16-13-22)21-6-8-23(9-7-21)32-19-20-4-2-1-3-5-20/h1-13,15-16,18,28H,14,17,19H2	BSIFHDFTPOIMPB-UHFFFAOYSA-N	115003	(*R)-7-((4-(benzyloxy)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 16a	HLA-DR4 protein			 8100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115003&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			850137	252664463							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131834	O=C1CCOc2cc(O[C@H](c3ccncc3)c3ccc(OCc4ccccc4)cc3)ccc21	InChI=1S/C28H23NO4/c30-26-14-17-31-27-18-24(10-11-25(26)27)33-28(22-12-15-29-16-13-22)21-6-8-23(9-7-21)32-19-20-4-2-1-3-5-20/h1-13,15-16,18,28H,14,17,19H2	BSIFHDFTPOIMPB-UHFFFAOYSA-N	115004	(*S)-7-((4-(benzyloxy)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 16b	HLA-DR4 protein			 9900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115004&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			838785	252664464							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131835	COc1ccc(COc2ccc([C@@H](Oc3ccc4c(c3)OCCC4=O)c3ccncc3)cc2)cc1	InChI=1S/C29H25NO5/c1-32-23-6-2-20(3-7-23)19-34-24-8-4-21(5-9-24)29(22-12-15-30-16-13-22)35-25-10-11-26-27(31)14-17-33-28(26)18-25/h2-13,15-16,18,29H,14,17,19H2,1H3	GJPODORIJHQQJU-UHFFFAOYSA-N	115005	(*R)-7-((4-((4-Methoxybenzyl)oxy)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 17a	HLA-DR4 protein			 5800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115005&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5842394	252664465							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131836	COc1ccc(COc2ccc([C@H](Oc3ccc4c(c3)OCCC4=O)c3ccncc3)cc2)cc1	InChI=1S/C29H25NO5/c1-32-23-6-2-20(3-7-23)19-34-24-8-4-21(5-9-24)29(22-12-15-30-16-13-22)35-25-10-11-26-27(31)14-17-33-28(26)18-25/h2-13,15-16,18,29H,14,17,19H2,1H3	GJPODORIJHQQJU-UHFFFAOYSA-N	115006	(*S)-7-((4-((4-Methoxybenzyl)oxy)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 17b	HLA-DR4 protein			 4900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115006&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6875163	252664466							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131837	NC(=O)c1ccc(C(Oc2ccc3c(c2)OCCC3=O)c2ccnc(C(F)(F)F)c2)cc1	InChI=1S/C23H17F3N2O4/c24-23(25,26)20-11-15(7-9-28-20)21(13-1-3-14(4-2-13)22(27)30)32-16-5-6-17-18(29)8-10-31-19(17)12-16/h1-7,9,11-12,21H,8,10H2,(H2,27,30)	IFGHUZBYSOCYQE-UHFFFAOYSA-N	115007	US12516038, Example 18a	HLA-DR4 protein			 1400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115007&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			901926	252664467							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131838	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccnc(C(F)(F)F)c2)cc1	InChI=1S/C23H17F3N2O4/c24-23(25,26)20-11-15(7-9-28-20)21(13-1-3-14(4-2-13)22(27)30)32-16-5-6-17-18(29)8-10-31-19(17)12-16/h1-7,9,11-12,21H,8,10H2,(H2,27,30)	IFGHUZBYSOCYQE-UHFFFAOYSA-N	115008	(*S)-4-(((4-oxochroman-7-yl)oxy)(2-(trifluoromethyl)pyridin-4-yl)methyl)benzamide::US12516038, Example 18b	HLA-DR4 protein			 950							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115008&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5729968	252664468							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131839	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2C(F)(F)F)cc1	InChI=1S/C23H17F3N2O4/c24-23(25,26)18-12-28-9-7-16(18)21(13-1-3-14(4-2-13)22(27)30)32-15-5-6-17-19(29)8-10-31-20(17)11-15/h1-7,9,11-12,21H,8,10H2,(H2,27,30)	JCUWBDZGYSDMHA-UHFFFAOYSA-N	115009	(*R)-4-(((4-oxochroman-7-yl)oxy)(3-(trifluoromethyl)pyridin-4-yl)methyl)benzamide::US12516038, Example 19a	HLA-DR4 protein			 820							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115009&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			16187060	252664469							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131840	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2C(F)(F)F)cc1	InChI=1S/C23H17F3N2O4/c24-23(25,26)18-12-28-9-7-16(18)21(13-1-3-14(4-2-13)22(27)30)32-15-5-6-17-19(29)8-10-31-20(17)11-15/h1-7,9,11-12,21H,8,10H2,(H2,27,30)	JCUWBDZGYSDMHA-UHFFFAOYSA-N	115010	(*S)-4-(((4-oxochroman-7-yl)oxy)(3-(trifluoromethyl)pyridin-4-yl)methyl)benzamide::US12516038, Example 19b	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115010&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			16188383	252664470							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131841	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2F)cc1	InChI=1S/C22H17FN2O4/c23-18-12-25-9-7-16(18)21(13-1-3-14(4-2-13)22(24)27)29-15-5-6-17-19(26)8-10-28-20(17)11-15/h1-7,9,11-12,21H,8,10H2,(H2,24,27)	GXWCWRZGEOSKTQ-UHFFFAOYSA-N	115011	(*R)-4-((3-fluoropyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 20a	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115011&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			16188699	252664471							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131842	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2F)cc1	InChI=1S/C22H17FN2O4/c23-18-12-25-9-7-16(18)21(13-1-3-14(4-2-13)22(24)27)29-15-5-6-17-19(26)8-10-28-20(17)11-15/h1-7,9,11-12,21H,8,10H2,(H2,24,27)	GXWCWRZGEOSKTQ-UHFFFAOYSA-N	115012	(*S)-4-((3-fluoropyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 20b	HLA-DR4 protein			 910							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115012&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			717858	252664472							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131843	Cc1cnccc1[C@H](Oc1ccc2c(c1)OCCC2=O)c1ccc(C(N)=O)cc1	InChI=1S/C23H20N2O4/c1-14-13-25-10-8-18(14)22(15-2-4-16(5-3-15)23(24)27)29-17-6-7-19-20(26)9-11-28-21(19)12-17/h2-8,10,12-13,22H,9,11H2,1H3,(H2,24,27)	UMEMYGMEDNZPFP-UHFFFAOYSA-N	115013	(*R)-4-((3-Methylpyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 21a	HLA-DR4 protein			 1000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115013&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5150753	252664473							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131844	Cc1cnccc1[C@@H](Oc1ccc2c(c1)OCCC2=O)c1ccc(C(N)=O)cc1	InChI=1S/C23H20N2O4/c1-14-13-25-10-8-18(14)22(15-2-4-16(5-3-15)23(24)27)29-17-6-7-19-20(26)9-11-28-21(19)12-17/h2-8,10,12-13,22H,9,11H2,1H3,(H2,24,27)	UMEMYGMEDNZPFP-UHFFFAOYSA-N	115014	(*S)-4-((3-Methylpyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 21b	HLA-DR4 protein			 640							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115014&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			1206157	252664474							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131845	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccnc3ccccc23)cc1	InChI=1S/C26H20N2O4/c27-26(30)17-7-5-16(6-8-17)25(20-11-13-28-22-4-2-1-3-19(20)22)32-18-9-10-21-23(29)12-14-31-24(21)15-18/h1-11,13,15,25H,12,14H2,(H2,27,30)	SGOQXUUXIJDCBU-UHFFFAOYSA-N	115015	(*R)-4-(((4-oxochroman-7-yl)oxy)(quinolin-4-yl)methyl)benzamide::US12516038, Example 22a	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115015&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5720547	252664475							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131846	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccnc3ccccc23)cc1	InChI=1S/C26H20N2O4/c27-26(30)17-7-5-16(6-8-17)25(20-11-13-28-22-4-2-1-3-19(20)22)32-18-9-10-21-23(29)12-14-31-24(21)15-18/h1-11,13,15,25H,12,14H2,(H2,27,30)	SGOQXUUXIJDCBU-UHFFFAOYSA-N	115016	(*S)-4-(((4-oxochroman-7-yl)oxy)(quinolin-4-yl)methyl)benzamide::US12516038, Example 22b	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115016&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			829296	252664476							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131847	COc1cnccc1[C@H](Oc1ccc2c(c1)OCCC2=O)c1ccc(C(N)=O)cc1	InChI=1S/C23H20N2O5/c1-28-21-13-25-10-8-18(21)22(14-2-4-15(5-3-14)23(24)27)30-16-6-7-17-19(26)9-11-29-20(17)12-16/h2-8,10,12-13,22H,9,11H2,1H3,(H2,24,27)	ZZTOSXBTNZAEGR-UHFFFAOYSA-N	115017	(*R)-4-((3-methoxypyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 23a	HLA-DR4 protein			 450							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115017&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			818268	252664477							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131848	COc1cnccc1[C@@H](Oc1ccc2c(c1)OCCC2=O)c1ccc(C(N)=O)cc1	InChI=1S/C23H20N2O5/c1-28-21-13-25-10-8-18(21)22(14-2-4-15(5-3-14)23(24)27)30-16-6-7-17-19(26)9-11-29-20(17)12-16/h2-8,10,12-13,22H,9,11H2,1H3,(H2,24,27)	ZZTOSXBTNZAEGR-UHFFFAOYSA-N	115018	(*S)-4-((3-methoxypyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 23b	HLA-DR4 protein			 680							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115018&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3128534	252664478							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131849	COc1cc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccc(C(N)=O)cc2)ccn1	InChI=1S/C23H20N2O5/c1-28-21-12-16(8-10-25-21)22(14-2-4-15(5-3-14)23(24)27)30-17-6-7-18-19(26)9-11-29-20(18)13-17/h2-8,10,12-13,22H,9,11H2,1H3,(H2,24,27)	SDGZSYGNKFTJBL-UHFFFAOYSA-N	115019	(*R)-4-((2-methoxypyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 24a	HLA-DR4 protein			 1400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115019&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			727295	252664479							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131850	COc1cc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccc(C(N)=O)cc2)ccn1	InChI=1S/C23H20N2O5/c1-28-21-12-16(8-10-25-21)22(14-2-4-15(5-3-14)23(24)27)30-17-6-7-18-19(26)9-11-29-20(18)13-17/h2-8,10,12-13,22H,9,11H2,1H3,(H2,24,27)	SDGZSYGNKFTJBL-UHFFFAOYSA-N	115020	(*S)-4-((2-methoxypyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 24b	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115020&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5766786	252664480							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131851	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2-c2ccccc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)20-8-6-19(7-9-20)27(22-12-14-30-17-24(22)18-4-2-1-3-5-18)34-21-10-11-23-25(31)13-15-33-26(23)16-21/h1-12,14,16-17,27H,13,15H2,(H2,29,32)	MIAOKNREFWTJCW-UHFFFAOYSA-N	115021	(*R)-4-(((4-oxochroman-7-yl)oxy)(3-phenylpyridin-4-yl)methyl)benzamide::US12516038, Example 25a	HLA-DR4 protein			 480							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115021&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5568081	252664481							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131852	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2-c2ccccc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)20-8-6-19(7-9-20)27(22-12-14-30-17-24(22)18-4-2-1-3-5-18)34-21-10-11-23-25(31)13-15-33-26(23)16-21/h1-12,14,16-17,27H,13,15H2,(H2,29,32)	MIAOKNREFWTJCW-UHFFFAOYSA-N	115023	(*S)-4-(((4-oxochroman-7-yl)oxy)(3-phenylpyridin-4-yl)methyl)benzamide::US12516038, Example 25b	HLA-DR4 protein			 490							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115023&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			7162438	252664482							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131853	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccnc(-c3ccccc3)c2)cc1	InChI=1S/C28H22N2O4/c29-28(32)20-8-6-19(7-9-20)27(21-12-14-30-24(16-21)18-4-2-1-3-5-18)34-22-10-11-23-25(31)13-15-33-26(23)17-22/h1-12,14,16-17,27H,13,15H2,(H2,29,32)	NPIFGELETAREQX-UHFFFAOYSA-N	115024	(*R)-4-(((4-oxochroman-7-yl)oxy)(2-phenylpyridin-4-yl)methyl)benzamide::US12516038, Example 26a	HLA-DR4 protein			 64000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115024&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			1480667	252664483							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131854	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccnc(-c3ccccc3)c2)cc1	InChI=1S/C28H22N2O4/c29-28(32)20-8-6-19(7-9-20)27(21-12-14-30-24(16-21)18-4-2-1-3-5-18)34-22-10-11-23-25(31)13-15-33-26(23)17-22/h1-12,14,16-17,27H,13,15H2,(H2,29,32)	NPIFGELETAREQX-UHFFFAOYSA-N	115025	(*S)-4-(((4-oxochroman-7-yl)oxy)(2-phenylpyridin-4-yl)methyl)benzamide::US12516038, Example 26b	HLA-DR4 protein			 88000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115025&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5525417	252664484							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131855	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2N)cc1	InChI=1S/C22H19N3O4/c23-18-12-25-9-7-16(18)21(13-1-3-14(4-2-13)22(24)27)29-15-5-6-17-19(26)8-10-28-20(17)11-15/h1-7,9,11-12,21H,8,10,23H2,(H2,24,27)	KEBHURRSSJONEB-UHFFFAOYSA-N	115026	(*R)-4-((3-aminopyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 27a	HLA-DR4 protein			 7300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115026&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			9581725	252664485							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131856	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2N)cc1	InChI=1S/C22H19N3O4/c23-18-12-25-9-7-16(18)21(13-1-3-14(4-2-13)22(24)27)29-15-5-6-17-19(26)8-10-28-20(17)11-15/h1-7,9,11-12,21H,8,10,23H2,(H2,24,27)	KEBHURRSSJONEB-UHFFFAOYSA-N	115027	(*S)-4-((3-aminopyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 27b	HLA-DR4 protein			 6400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115027&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3838280	252664486							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131857	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccnc(N)c2)cc1	InChI=1S/C22H19N3O4/c23-20-11-15(7-9-25-20)21(13-1-3-14(4-2-13)22(24)27)29-16-5-6-17-18(26)8-10-28-19(17)12-16/h1-7,9,11-12,21H,8,10H2,(H2,23,25)(H2,24,27)	OCLWPCRHHXOEQV-UHFFFAOYSA-N	115028	(*R)-4-((2-aminopyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 28a	HLA-DR4 protein			 1800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115028&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6409760	252664487							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131858	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccnc(N)c2)cc1	InChI=1S/C22H19N3O4/c23-20-11-15(7-9-25-20)21(13-1-3-14(4-2-13)22(24)27)29-16-5-6-17-18(26)8-10-28-19(17)12-16/h1-7,9,11-12,21H,8,10H2,(H2,23,25)(H2,24,27)	OCLWPCRHHXOEQV-UHFFFAOYSA-N	115029	(*S)-4-((2-aminopyridin-4-yl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 28b	HLA-DR4 protein			 1700							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115029&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6401039	252664488							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131859	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccccc2)cc1	InChI=1S/C23H19NO4/c24-23(26)17-8-6-16(7-9-17)22(15-4-2-1-3-5-15)28-18-10-11-19-20(25)12-13-27-21(19)14-18/h1-11,14,22H,12-13H2,(H2,24,26)	NIJZUFGCKPDYEU-UHFFFAOYSA-N	115030	(*R)-4-(((4-oxochroman-7-yl)oxy)(phenyl)methyl)benzamide::US12516038, Example 29a	HLA-DR4 protein			 1100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115030&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2453287	252664489							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131860	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccccc2)cc1	InChI=1S/C23H19NO4/c24-23(26)17-8-6-16(7-9-17)22(15-4-2-1-3-5-15)28-18-10-11-19-20(25)12-13-27-21(19)14-18/h1-11,14,22H,12-13H2,(H2,24,26)	NIJZUFGCKPDYEU-UHFFFAOYSA-N	115031	(*S)-4-(((4-oxochroman-7-yl)oxy)(phenyl)methyl)benzamide::US12516038, Example 29b	HLA-DR4 protein			 960							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115031&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3462706	252664490							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131861	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccc(Cl)cc2)cc1	InChI=1S/C23H18ClNO4/c24-17-7-5-15(6-8-17)22(14-1-3-16(4-2-14)23(25)27)29-18-9-10-19-20(26)11-12-28-21(19)13-18/h1-10,13,22H,11-12H2,(H2,25,27)	ZIGBECZPUJONOD-UHFFFAOYSA-N	115032	(*R)-4-((4-Chlorophenyl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 30a	HLA-DR4 protein			 930							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115032&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			16196079	252664491							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131862	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccc(Cl)cc2)cc1	InChI=1S/C23H18ClNO4/c24-17-7-5-15(6-8-17)22(14-1-3-16(4-2-14)23(25)27)29-18-9-10-19-20(26)11-12-28-21(19)13-18/h1-10,13,22H,11-12H2,(H2,25,27)	ZIGBECZPUJONOD-UHFFFAOYSA-N	115033	(*S)-4-((4-Chlorophenyl)((4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 30b	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115033&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			9630484	252664492							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131863	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2cccnc2)cc1	InChI=1S/C22H18N2O4/c23-22(26)15-5-3-14(4-6-15)21(16-2-1-10-24-13-16)28-17-7-8-18-19(25)9-11-27-20(18)12-17/h1-8,10,12-13,21H,9,11H2,(H2,23,26)	YLPRUKBTYDACIB-UHFFFAOYSA-N	115034	(*R)-4-(((4-oxochroman-7-yl)oxy)(pyridin-3-yl)methyl)benzamide::US12516038, Example 31a	HLA-DR4 protein			 850							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115034&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2083029	252664493							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131864	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2cccnc2)cc1	InChI=1S/C22H18N2O4/c23-22(26)15-5-3-14(4-6-15)21(16-2-1-10-24-13-16)28-17-7-8-18-19(25)9-11-27-20(18)12-17/h1-8,10,12-13,21H,9,11H2,(H2,23,26)	YLPRUKBTYDACIB-UHFFFAOYSA-N	115036	(*S)-4-(((4-oxochroman-7-yl)oxy)(pyridin-3-yl)methyl)benzamide::US12516038, Example 31b	HLA-DR4 protein			 640							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115036&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2460931	252664494							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131865	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccccn2)cc1	InChI=1S/C22H18N2O4/c23-22(26)15-6-4-14(5-7-15)21(18-3-1-2-11-24-18)28-16-8-9-17-19(25)10-12-27-20(17)13-16/h1-9,11,13,21H,10,12H2,(H2,23,26)	SLYSMQJRZBQVHG-UHFFFAOYSA-N	115037	(*R)-4-(((4-oxochroman-7-yl)oxy)(pyridin-2-yl)methyl)benzamide::US12516038, Example 32a	HLA-DR4 protein			 3600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115037&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			941833	252664495							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131866	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccccn2)cc1	InChI=1S/C22H18N2O4/c23-22(26)15-6-4-14(5-7-15)21(18-3-1-2-11-24-18)28-16-8-9-17-19(25)10-12-27-20(17)13-16/h1-9,11,13,21H,10,12H2,(H2,23,26)	SLYSMQJRZBQVHG-UHFFFAOYSA-N	115038	(*S)-4-(((4-oxochroman-7-yl)oxy)(pyridin-2-yl)methyl)benzamide::US12516038, Example 32b	HLA-DR4 protein			 1900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115038&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			251469	252664496							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131867	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncn2)cc1	InChI=1S/C21H17N3O4/c22-21(26)14-3-1-13(2-4-14)20(17-7-9-23-12-24-17)28-15-5-6-16-18(25)8-10-27-19(16)11-15/h1-7,9,11-12,20H,8,10H2,(H2,22,26)	WUUMSVHEKBZLNX-UHFFFAOYSA-N	115039	(*R)-4-(((4-Oxochroman-7-yl)oxy)(pyrimidin-4-yl)methyl)benzamide::US12516038, Example 33a	HLA-DR4 protein			 580							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115039&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			91554190	252664497							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131868	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncn2)cc1	InChI=1S/C21H17N3O4/c22-21(26)14-3-1-13(2-4-14)20(17-7-9-23-12-24-17)28-15-5-6-16-18(25)8-10-27-19(16)11-15/h1-7,9,11-12,20H,8,10H2,(H2,22,26)	WUUMSVHEKBZLNX-UHFFFAOYSA-N	115040	(*S)-4-(((4-Oxochroman-7-yl)oxy)(pyrimidin-4-yl)methyl)benzamide::US12516038, Example 33b	HLA-DR4 protein			 590							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115040&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6901173	252664498							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131869	CNC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C23H20N2O4/c1-24-23(27)17-4-2-15(3-5-17)22(16-8-11-25-12-9-16)29-18-6-7-19-20(26)10-13-28-21(19)14-18/h2-9,11-12,14,22H,10,13H2,1H3,(H,24,27)	NGSVVOWAFYNKMI-UHFFFAOYSA-N	115041	(*R)—N-methyl-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 34a	HLA-DR4 protein			 800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115041&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2740372	252664499							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131870	CNC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C23H20N2O4/c1-24-23(27)17-4-2-15(3-5-17)22(16-8-11-25-12-9-16)29-18-6-7-19-20(26)10-13-28-21(19)14-18/h2-9,11-12,14,22H,10,13H2,1H3,(H,24,27)	NGSVVOWAFYNKMI-UHFFFAOYSA-N	115042	(*S)—N-methyl-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 34b	HLA-DR4 protein			 690							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115042&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2742891	252664500							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131871	Cc1cc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)ccc1C(N)=O	InChI=1S/C23H20N2O4/c1-14-12-16(2-4-18(14)23(24)27)22(15-6-9-25-10-7-15)29-17-3-5-19-20(26)8-11-28-21(19)13-17/h2-7,9-10,12-13,22H,8,11H2,1H3,(H2,24,27)	YIDILBNIWQCYET-UHFFFAOYSA-N	115043	(*R)-2-methyl-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 35a	HLA-DR4 protein			 960							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115043&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2816406	252664501							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131872	Cc1cc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)ccc1C(N)=O	InChI=1S/C23H20N2O4/c1-14-12-16(2-4-18(14)23(24)27)22(15-6-9-25-10-7-15)29-17-3-5-19-20(26)8-11-28-21(19)13-17/h2-7,9-10,12-13,22H,8,11H2,1H3,(H2,24,27)	YIDILBNIWQCYET-UHFFFAOYSA-N	115045	(*S)-2-methyl-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 35b	HLA-DR4 protein			 830							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115045&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			983644	252664503							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131873	Cc1cc(C(N)=O)ccc1[C@H](Oc1ccc2c(c1)OCCC2=O)c1ccncc1	InChI=1S/C23H20N2O4/c1-14-12-16(23(24)27)2-4-18(14)22(15-6-9-25-10-7-15)29-17-3-5-19-20(26)8-11-28-21(19)13-17/h2-7,9-10,12-13,22H,8,11H2,1H3,(H2,24,27)	PVOJRBIPIHNGDP-UHFFFAOYSA-N	115046	(*R)-3-methyl-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 36a	HLA-DR4 protein			 550							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115046&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			23723128	252664504							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131874	Cc1cc(C(N)=O)ccc1[C@@H](Oc1ccc2c(c1)OCCC2=O)c1ccncc1	InChI=1S/C23H20N2O4/c1-14-12-16(23(24)27)2-4-18(14)22(15-6-9-25-10-7-15)29-17-3-5-19-20(26)8-11-28-21(19)13-17/h2-7,9-10,12-13,22H,8,11H2,1H3,(H2,24,27)	PVOJRBIPIHNGDP-UHFFFAOYSA-N	115047	(*S)-3-methyl-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 36b	HLA-DR4 protein			 570							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115047&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			555490	252664505							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131875	N#Cc1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)c2ccccc12	InChI=1S/C26H18N2O3/c27-16-18-5-7-22(21-4-2-1-3-20(18)21)26(17-9-12-28-13-10-17)31-19-6-8-23-24(29)11-14-30-25(23)15-19/h1-10,12-13,15,26H,11,14H2	BVVFXTXQAGODCO-UHFFFAOYSA-N	115048	(*R)-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)-1-naphthonitrile::US12516038, Example 37a	HLA-DR4 protein			 33000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115048&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			7099036	252664506							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131876	N#Cc1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)c2ccccc12	InChI=1S/C26H18N2O3/c27-16-18-5-7-22(21-4-2-1-3-20(18)21)26(17-9-12-28-13-10-17)31-19-6-8-23-24(29)11-14-30-25(23)15-19/h1-10,12-13,15,26H,11,14H2	BVVFXTXQAGODCO-UHFFFAOYSA-N	115049	(*S)-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)-1-naphthonitrile::US12516038, Example 37b	HLA-DR4 protein			 24000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115049&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5368817	252664507							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131877	O=C1CCOc2cc(O[C@@H](c3ccncc3)C3CCCCC3)ccc21	InChI=1S/C21H23NO3/c23-19-10-13-24-20-14-17(6-7-18(19)20)25-21(15-4-2-1-3-5-15)16-8-11-22-12-9-16/h6-9,11-12,14-15,21H,1-5,10,13H2	IPKVYLYVZDFOPE-UHFFFAOYSA-N	115050	(*R)-7-(cyclohexyl(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 38a	HLA-DR4 protein			 4600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115050&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2948897	252664508							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131878	O=C1CCOc2cc(O[C@H](c3ccncc3)C3CCCCC3)ccc21	InChI=1S/C21H23NO3/c23-19-10-13-24-20-14-17(6-7-18(19)20)25-21(15-4-2-1-3-5-15)16-8-11-22-12-9-16/h6-9,11-12,14-15,21H,1-5,10,13H2	IPKVYLYVZDFOPE-UHFFFAOYSA-N	115051	(*S)-7-(cyclohexyl(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 38b	HLA-DR4 protein			 4100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115051&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3775159	252664509							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131879	C[C@@H]1CC(=O)c2ccc(O[C@H](c3ccncc3)c3ccc(C(N)=O)cc3)cc2O1	InChI=1S/C23H20N2O4/c1-14-12-20(26)19-7-6-18(13-21(19)28-14)29-22(16-8-10-25-11-9-16)15-2-4-17(5-3-15)23(24)27/h2-11,13-14,22H,12H2,1H3,(H2,24,27)	NCICPYBTSYXNHP-UHFFFAOYSA-N	115052	4-((*S)—(((*R)-2-Methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 39a	HLA-DR4 protein			 1100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115052&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2907426	252664510							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131880	C[C@@H]1CC(=O)c2ccc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)cc2O1	InChI=1S/C23H20N2O4/c1-14-12-20(26)19-7-6-18(13-21(19)28-14)29-22(16-8-10-25-11-9-16)15-2-4-17(5-3-15)23(24)27/h2-11,13-14,22H,12H2,1H3,(H2,24,27)	NCICPYBTSYXNHP-UHFFFAOYSA-N	115053	4-((*R)—(((*R)-2-Methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 39b	HLA-DR4 protein			 850							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115053&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6462835	252664511							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131881	C[C@H]1CC(=O)c2ccc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)cc2O1	InChI=1S/C23H20N2O4/c1-14-12-20(26)19-7-6-18(13-21(19)28-14)29-22(16-8-10-25-11-9-16)15-2-4-17(5-3-15)23(24)27/h2-11,13-14,22H,12H2,1H3,(H2,24,27)	NCICPYBTSYXNHP-UHFFFAOYSA-N	115055	4-((*R)—(((*S)-2-Methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 39c	HLA-DR4 protein			 990							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115055&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			888298	252664513							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131882	C[C@H]1CC(=O)c2ccc(O[C@H](c3ccncc3)c3ccc(C(N)=O)cc3)cc2O1	InChI=1S/C23H20N2O4/c1-14-12-20(26)19-7-6-18(13-21(19)28-14)29-22(16-8-10-25-11-9-16)15-2-4-17(5-3-15)23(24)27/h2-11,13-14,22H,12H2,1H3,(H2,24,27)	NCICPYBTSYXNHP-UHFFFAOYSA-N	115056	4-((*S)—(((*S)-2-Methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 39d	HLA-DR4 protein			 1000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115056&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			822280	252664514							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131883	CC[C@@H]1CC(=O)c2ccc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)cc2O1	InChI=1S/C24H22N2O4/c1-2-18-13-21(27)20-8-7-19(14-22(20)29-18)30-23(16-9-11-26-12-10-16)15-3-5-17(6-4-15)24(25)28/h3-12,14,18,23H,2,13H2,1H3,(H2,25,28)	BLPFSHBSYCOWBY-UHFFFAOYSA-N	115057	4-((*R)—(((*R)-2-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 40a	HLA-DR4 protein			 1500							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115057&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			948254	252664515							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131884	CC[C@H]1CC(=O)c2ccc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)cc2O1	InChI=1S/C24H22N2O4/c1-2-18-13-21(27)20-8-7-19(14-22(20)29-18)30-23(16-9-11-26-12-10-16)15-3-5-17(6-4-15)24(25)28/h3-12,14,18,23H,2,13H2,1H3,(H2,25,28)	BLPFSHBSYCOWBY-UHFFFAOYSA-N	115058	4-((*R)—(((*S)-2-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 40b	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115058&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			718328	252664516							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131885	CC[C@@H]1CC(=O)c2ccc(O[C@H](c3ccncc3)c3ccc(C(N)=O)cc3)cc2O1	InChI=1S/C24H22N2O4/c1-2-18-13-21(27)20-8-7-19(14-22(20)29-18)30-23(16-9-11-26-12-10-16)15-3-5-17(6-4-15)24(25)28/h3-12,14,18,23H,2,13H2,1H3,(H2,25,28)	BLPFSHBSYCOWBY-UHFFFAOYSA-N	115060	4-((*S)—(((*R)-2-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 41a	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115060&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			20855152	252664518							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131886	CC[C@H]1CC(=O)c2ccc(O[C@H](c3ccncc3)c3ccc(C(N)=O)cc3)cc2O1	InChI=1S/C24H22N2O4/c1-2-18-13-21(27)20-8-7-19(14-22(20)29-18)30-23(16-9-11-26-12-10-16)15-3-5-17(6-4-15)24(25)28/h3-12,14,18,23H,2,13H2,1H3,(H2,25,28)	BLPFSHBSYCOWBY-UHFFFAOYSA-N	115061	4-((*S)—(((*S)-2-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 41b	HLA-DR4 protein			 1100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115061&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2678142	252664519							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131887	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)O[C@@H](c2ccccc2)CC3=O)c2ccncc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)21-8-6-19(7-9-21)27(20-12-14-30-15-13-20)33-22-10-11-23-24(31)17-25(34-26(23)16-22)18-4-2-1-3-5-18/h1-16,25,27H,17H2,(H2,29,32)	BNVBAVOUVMIWQH-UHFFFAOYSA-N	115062	4-((*S)—(((*R)-4-oxo-2-phenylchroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 42a	HLA-DR4 protein			 3800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115062&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24791023	252664520							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131888	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)O[C@H](c2ccccc2)CC3=O)c2ccncc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)21-8-6-19(7-9-21)27(20-12-14-30-15-13-20)33-22-10-11-23-24(31)17-25(34-26(23)16-22)18-4-2-1-3-5-18/h1-16,25,27H,17H2,(H2,29,32)	BNVBAVOUVMIWQH-UHFFFAOYSA-N	115063	4-((*S)—(((*S)-4-oxo-2-phenylchroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 42b	HLA-DR4 protein			 7500							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115063&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			17096079	252664521							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131889	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)O[C@@H](c2ccccc2)CC3=O)c2ccncc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)21-8-6-19(7-9-21)27(20-12-14-30-15-13-20)33-22-10-11-23-24(31)17-25(34-26(23)16-22)18-4-2-1-3-5-18/h1-16,25,27H,17H2,(H2,29,32)	BNVBAVOUVMIWQH-UHFFFAOYSA-N	115064	US12516038, Example 43a	HLA-DR4 protein			 3600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115064&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24793608	252664522							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131890	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)O[C@H](c2ccccc2)CC3=O)c2ccncc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)21-8-6-19(7-9-21)27(20-12-14-30-15-13-20)33-22-10-11-23-24(31)17-25(34-26(23)16-22)18-4-2-1-3-5-18/h1-16,25,27H,17H2,(H2,29,32)	BNVBAVOUVMIWQH-UHFFFAOYSA-N	115065	4-((*R)—(((*S)-4-oxo-2-phenylchroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 43b	HLA-DR4 protein			 4900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115065&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24816782	252664523							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131891	C[C@@H]1COc2cc(O[C@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C23H20N2O4/c1-14-13-28-20-12-18(6-7-19(20)21(14)26)29-22(16-8-10-25-11-9-16)15-2-4-17(5-3-15)23(24)27/h2-12,14,22H,13H2,1H3,(H2,24,27)	TXBCYWLRKPMLEZ-UHFFFAOYSA-N	115066	4-((*S)—(((*R)-3-Methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 44a	HLA-DR4 protein			 1600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115066&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			17505658	252664524							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131892	C[C@@H]1COc2cc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C23H20N2O4/c1-14-13-28-20-12-18(6-7-19(20)21(14)26)29-22(16-8-10-25-11-9-16)15-2-4-17(5-3-15)23(24)27/h2-12,14,22H,13H2,1H3,(H2,24,27)	TXBCYWLRKPMLEZ-UHFFFAOYSA-N	115067	4-((*R)—(((*R)-3-Methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 44b	HLA-DR4 protein			 1100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115067&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			765392	252664525							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131893	C[C@H]1COc2cc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C23H20N2O4/c1-14-13-28-20-12-18(6-7-19(20)21(14)26)29-22(16-8-10-25-11-9-16)15-2-4-17(5-3-15)23(24)27/h2-12,14,22H,13H2,1H3,(H2,24,27)	TXBCYWLRKPMLEZ-UHFFFAOYSA-N	115068	4-((*R)—(((*S)-3-Methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 44c	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115068&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24239799	252664526							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131894	CC1COc2cc(OC(c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C23H20N2O4/c1-14-13-28-20-12-18(6-7-19(20)21(14)26)29-22(16-8-10-25-11-9-16)15-2-4-17(5-3-15)23(24)27/h2-12,14,22H,13H2,1H3,(H2,24,27)	TXBCYWLRKPMLEZ-UHFFFAOYSA-N	115069	US12516038, Example 44d	HLA-DR4 protein			 850							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115069&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5824575	252664527							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131895	CC[C@@H]1COc2cc(O[C@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C24H22N2O4/c1-2-15-14-29-21-13-19(7-8-20(21)22(15)27)30-23(17-9-11-26-12-10-17)16-3-5-18(6-4-16)24(25)28/h3-13,15,23H,2,14H2,1H3,(H2,25,28)	LLLOERSEJXVJJQ-UHFFFAOYSA-N	115070	4-((*S)—(((*R)-3-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 45a	HLA-DR4 protein			 1100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115070&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24819635	252664528							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131896	CC[C@H]1COc2cc(O[C@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C24H22N2O4/c1-2-15-14-29-21-13-19(7-8-20(21)22(15)27)30-23(17-9-11-26-12-10-17)16-3-5-18(6-4-16)24(25)28/h3-13,15,23H,2,14H2,1H3,(H2,25,28)	LLLOERSEJXVJJQ-UHFFFAOYSA-N	115071	4-((*S)—(((*S)-3-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 45b	HLA-DR4 protein			 1400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115071&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			653562	252664529							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
131897	CC[C@@H]1COc2cc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C24H22N2O4/c1-2-15-14-29-21-13-19(7-8-20(21)22(15)27)30-23(17-9-11-26-12-10-17)16-3-5-18(6-4-16)24(25)28/h3-13,15,23H,2,14H2,1H3,(H2,25,28)	LLLOERSEJXVJJQ-UHFFFAOYSA-N	115072	4-((*R)—(((*R)-3-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 46a	HLA-DR4 protein			 970							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115072&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24892260	252664530							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135711	CC[C@H]1COc2cc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C24H22N2O4/c1-2-15-14-29-21-13-19(7-8-20(21)22(15)27)30-23(17-9-11-26-12-10-17)16-3-5-18(6-4-16)24(25)28/h3-13,15,23H,2,14H2,1H3,(H2,25,28)	LLLOERSEJXVJJQ-UHFFFAOYSA-N	115073	4-((*R)—(((*S)-3-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 46b	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115073&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			18109372	252664531							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135712	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCC(c2ccccc2)C3=O)c2ccncc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)21-8-6-19(7-9-21)27(20-12-14-30-15-13-20)34-22-10-11-23-25(16-22)33-17-24(26(23)31)18-4-2-1-3-5-18/h1-16,24,27H,17H2,(H2,29,32)	DPLRIWNMDQEBSP-UHFFFAOYSA-N	115074	US12516038, Example 47	HLA-DR4 protein			 6500							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115074&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			18077761	252664532							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135713	Cc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C23H20N2O4/c1-14-20(7-6-18-19(26)10-13-28-21(14)18)29-22(16-8-11-25-12-9-16)15-2-4-17(5-3-15)23(24)27/h2-9,11-12,22H,10,13H2,1H3,(H2,24,27)	PTSUFACLPOFVFN-UHFFFAOYSA-N	115075	(*R)-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 48a	HLA-DR4 protein			 680							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115075&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24982228	252664533							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135714	Cc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C23H20N2O4/c1-14-20(7-6-18-19(26)10-13-28-21(14)18)29-22(16-8-11-25-12-9-16)15-2-4-17(5-3-15)23(24)27/h2-9,11-12,22H,10,13H2,1H3,(H2,24,27)	PTSUFACLPOFVFN-UHFFFAOYSA-N	115077	(*S)-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 48b	HLA-DR4 protein			 690							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115077&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			25161651	252664535							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135715	Cc1cc2c(cc1O[C@@H](c1ccncc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C23H20N2O4/c1-14-12-18-19(26)8-11-28-21(18)13-20(14)29-22(16-6-9-25-10-7-16)15-2-4-17(5-3-15)23(24)27/h2-7,9-10,12-13,22H,8,11H2,1H3,(H2,24,27)	BRDQNKAKKLJWEG-UHFFFAOYSA-N	115078	(*R)-4-(((6-Methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 49a	HLA-DR4 protein			 570							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115078&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			714839	252664536							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135716	Cc1cc2c(cc1O[C@H](c1ccncc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C23H20N2O4/c1-14-12-18-19(26)8-11-28-21(18)13-20(14)29-22(16-6-9-25-10-7-16)15-2-4-17(5-3-15)23(24)27/h2-7,9-10,12-13,22H,8,11H2,1H3,(H2,24,27)	BRDQNKAKKLJWEG-UHFFFAOYSA-N	115079	(*S)-4-(((6-Methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 49b	HLA-DR4 protein			 1000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115079&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			4390429	252664537							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135717	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2F)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H17FN2O4/c23-19-18(6-5-16-17(26)9-12-28-21(16)19)29-20(14-7-10-25-11-8-14)13-1-3-15(4-2-13)22(24)27/h1-8,10-11,20H,9,12H2,(H2,24,27)	IQWLOSOFLCPQRD-UHFFFAOYSA-N	115080	(*R)-4-(((8-Fluoro-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 50a	HLA-DR4 protein			 1900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115080&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			17747785	252664538							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135718	NC(=O)c1ccc([C@H](Oc2ccc3c(c2F)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H17FN2O4/c23-19-18(6-5-16-17(26)9-12-28-21(16)19)29-20(14-7-10-25-11-8-14)13-1-3-15(4-2-13)22(24)27/h1-8,10-11,20H,9,12H2,(H2,24,27)	IQWLOSOFLCPQRD-UHFFFAOYSA-N	115081	(*S)-4-(((8-Fluoro-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 50b	HLA-DR4 protein			 1900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115081&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			44142278	252664539							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135719	NC(=O)c1ccc([C@@H](Oc2cc(F)c3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H17FN2O4/c23-17-11-16(12-19-20(17)18(26)7-10-28-19)29-21(14-5-8-25-9-6-14)13-1-3-15(4-2-13)22(24)27/h1-6,8-9,11-12,21H,7,10H2,(H2,24,27)	PUHCHPQAHKXWDX-UHFFFAOYSA-N	115082	(*R)-4-(((5-Fluoro-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 51a	HLA-DR4 protein			 3600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115082	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115082&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2375679	252664540							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135720	NC(=O)c1ccc([C@H](Oc2cc(F)c3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H17FN2O4/c23-17-11-16(12-19-20(17)18(26)7-10-28-19)29-21(14-5-8-25-9-6-14)13-1-3-15(4-2-13)22(24)27/h1-6,8-9,11-12,21H,7,10H2,(H2,24,27)	PUHCHPQAHKXWDX-UHFFFAOYSA-N	115083	(*S)-4-(((5-Fluoro-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 51b	HLA-DR4 protein			 3500							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115083&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			8278086	252664541							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135721	NC(=O)c1ccc([C@@H](Oc2cc3c(cc2F)C(=O)CCO3)c2ccncc2)cc1	InChI=1S/C22H17FN2O4/c23-17-11-16-18(26)7-10-28-19(16)12-20(17)29-21(14-5-8-25-9-6-14)13-1-3-15(4-2-13)22(24)27/h1-6,8-9,11-12,21H,7,10H2,(H2,24,27)	QFKBUJSVXINBPD-UHFFFAOYSA-N	115084	(*R)-4-(((6-Fluoro-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 52a	HLA-DR4 protein			 230							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115084&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			4003315	252664542							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135722	NC(=O)c1ccc([C@H](Oc2cc3c(cc2F)C(=O)CCO3)c2ccncc2)cc1	InChI=1S/C22H17FN2O4/c23-17-11-16-18(26)7-10-28-19(16)12-20(17)29-21(14-5-8-25-9-6-14)13-1-3-15(4-2-13)22(24)27/h1-6,8-9,11-12,21H,7,10H2,(H2,24,27)	QFKBUJSVXINBPD-UHFFFAOYSA-N	115086	(*S)-4-(((6-Fluoro-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 52b	HLA-DR4 protein			 300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115086&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			73101	252664543							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135723	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2-c2ccccc2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)21-8-6-19(7-9-21)26(20-12-15-30-16-13-20)34-24-11-10-22-23(31)14-17-33-27(22)25(24)18-4-2-1-3-5-18/h1-13,15-16,26H,14,17H2,(H2,29,32)	MQAKACHDWMGJAA-UHFFFAOYSA-N	115087	(*R)-4-(((4-oxo-8-phenylchroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 53a	HLA-DR4 protein			 800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115087&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			236188	252664544							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135724	NC(=O)c1ccc([C@H](Oc2ccc3c(c2-c2ccccc2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)21-8-6-19(7-9-21)26(20-12-15-30-16-13-20)34-24-11-10-22-23(31)14-17-33-27(22)25(24)18-4-2-1-3-5-18/h1-13,15-16,26H,14,17H2,(H2,29,32)	MQAKACHDWMGJAA-UHFFFAOYSA-N	115088	(*S)-4-(((4-oxo-8-phenylchroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 53b	HLA-DR4 protein			 600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115088&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			238435	252664545							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135725	NC(=O)c1ccc([C@@H](Oc2cc3c(cc2-c2ccccc2)C(=O)CCO3)c2ccncc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)21-8-6-19(7-9-21)27(20-10-13-30-14-11-20)34-26-17-25-23(24(31)12-15-33-25)16-22(26)18-4-2-1-3-5-18/h1-11,13-14,16-17,27H,12,15H2,(H2,29,32)	PUPAZVCKOYSOAY-UHFFFAOYSA-N	115089	(*R)-4-(((4-oxo-6-phenylchroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 54a	HLA-DR4 protein			 630							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115089&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			91899744	252664546							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135726	NC(=O)c1ccc([C@H](Oc2cc3c(cc2-c2ccccc2)C(=O)CCO3)c2ccncc2)cc1	InChI=1S/C28H22N2O4/c29-28(32)21-8-6-19(7-9-21)27(20-10-13-30-14-11-20)34-26-17-25-23(24(31)12-15-33-25)16-22(26)18-4-2-1-3-5-18/h1-11,13-14,16-17,27H,12,15H2,(H2,29,32)	PUPAZVCKOYSOAY-UHFFFAOYSA-N	115090	(*S)-4-(((4-oxo-6-phenylchroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 54b	HLA-DR4 protein			 870							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115090&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			243153	252664547							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135727	NCC1COc2cc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C23H21N3O4/c24-12-17-13-29-20-11-18(5-6-19(20)21(17)27)30-22(15-7-9-26-10-8-15)14-1-3-16(4-2-14)23(25)28/h1-11,17,22H,12-13,24H2,(H2,25,28)	GVZXANBPZSZADB-UHFFFAOYSA-N	115091	US12516038, Example 55	HLA-DR4 protein			 930							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115091&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			248223	252664548							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135728	CC1(C)COc2cc(O[C@@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C24H22N2O4/c1-24(2)14-29-20-13-18(7-8-19(20)22(24)27)30-21(16-9-11-26-12-10-16)15-3-5-17(6-4-15)23(25)28/h3-13,21H,14H2,1-2H3,(H2,25,28)	UVGXXZJQJUFZIK-UHFFFAOYSA-N	115092	(*R)-4-(((3,3-dimethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 56a	HLA-DR4 protein			 1400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115092&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			263564	252664549							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135729	CC1(C)COc2cc(O[C@H](c3ccncc3)c3ccc(C(N)=O)cc3)ccc2C1=O	InChI=1S/C24H22N2O4/c1-24(2)14-29-20-13-18(7-8-19(20)22(24)27)30-21(16-9-11-26-12-10-16)15-3-5-17(6-4-15)23(25)28/h3-13,21H,14H2,1-2H3,(H2,25,28)	UVGXXZJQJUFZIK-UHFFFAOYSA-N	115094	(*S)-4-(((3,3-dimethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 56b	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115094&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			277303	252664551							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135730	Cc1c(O[C@@H](c2ccc(Cl)cc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H20ClNO4/c1-14-21(11-10-19-20(27)12-13-29-22(14)19)30-23(16-6-8-18(25)9-7-16)15-2-4-17(5-3-15)24(26)28/h2-11,23H,12-13H2,1H3,(H2,26,28)	UDCOQMLDBQJHKU-UHFFFAOYSA-N	115095	(*R)-4-((4-chlorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 57a	HLA-DR4 protein			 2300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115095&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			293475	252664552							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135731	Cc1c(O[C@H](c2ccc(Cl)cc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H20ClNO4/c1-14-21(11-10-19-20(27)12-13-29-22(14)19)30-23(16-6-8-18(25)9-7-16)15-2-4-17(5-3-15)24(26)28/h2-11,23H,12-13H2,1H3,(H2,26,28)	UDCOQMLDBQJHKU-UHFFFAOYSA-N	115096	(*S)-4-((4-chlorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 57b	HLA-DR4 protein			 2000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115096&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			298444	252664553							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135732	Cc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)c(F)cc2c1OCCC2=O	InChI=1S/C23H19FN2O4/c1-13-20-17(19(27)8-11-29-20)12-18(24)21(13)30-22(15-6-9-26-10-7-15)14-2-4-16(5-3-14)23(25)28/h2-7,9-10,12,22H,8,11H2,1H3,(H2,25,28)	MQJCIVQEMXRTAH-UHFFFAOYSA-N	115097	(*R)-4-(((6-fluoro-8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 58a	HLA-DR4 protein			 330							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115097&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			328728	252664554							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135733	Cc1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2)c(F)cc2c1OCCC2=O	InChI=1S/C23H19FN2O4/c1-13-20-17(19(27)8-11-29-20)12-18(24)21(13)30-22(15-6-9-26-10-7-15)14-2-4-16(5-3-14)23(25)28/h2-7,9-10,12,22H,8,11H2,1H3,(H2,25,28)	MQJCIVQEMXRTAH-UHFFFAOYSA-N	115098	(*S)-4-(((6-fluoro-8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 58b	HLA-DR4 protein			 730							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115098&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			46904954	252664555							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135734	Cc1c(O[C@H](c2ccc(C#N)cc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C25H20N2O4/c1-15-22(11-10-20-21(28)12-13-30-23(15)20)31-24(17-4-2-16(14-26)3-5-17)18-6-8-19(9-7-18)25(27)29/h2-11,24H,12-13H2,1H3,(H2,27,29)	DTLRXTAEBPOVAQ-UHFFFAOYSA-N	115099	(*R)-4-((4-cyanophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 59a	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115099&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			46943664	252664556							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135735	Cc1c(O[C@@H](c2ccc(C#N)cc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C25H20N2O4/c1-15-22(11-10-20-21(28)12-13-30-23(15)20)31-24(17-4-2-16(14-26)3-5-17)18-6-8-19(9-7-18)25(27)29/h2-11,24H,12-13H2,1H3,(H2,27,29)	DTLRXTAEBPOVAQ-UHFFFAOYSA-N	115100	(*S)-4-((4-cyanophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 59b	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115100&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			46948381	252664557							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135736	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2cccc(C#N)c2)ccc2c1OCCC2=O	InChI=1S/C25H20N2O4/c1-15-22(10-9-20-21(28)11-12-30-23(15)20)31-24(19-4-2-3-16(13-19)14-26)17-5-7-18(8-6-17)25(27)29/h2-10,13,24H,11-12H2,1H3,(H2,27,29)	HFQWIQPWLNJWNI-UHFFFAOYSA-N	115102	(*R)-4-((3-cyanophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 60a	HLA-DR4 protein			 1800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115102&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			49778774	252664558							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135737	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2cccc(C#N)c2)ccc2c1OCCC2=O	InChI=1S/C25H20N2O4/c1-15-22(10-9-20-21(28)11-12-30-23(15)20)31-24(19-4-2-3-16(13-19)14-26)17-5-7-18(8-6-17)25(27)29/h2-10,13,24H,11-12H2,1H3,(H2,27,29)	HFQWIQPWLNJWNI-UHFFFAOYSA-N	115103	(*S)-4-((3-cyanophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 60b	HLA-DR4 protein			 2000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115103&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			49789405	252664559							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135738	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2ccccc2C#N)ccc2c1OCCC2=O	InChI=1S/C25H20N2O4/c1-15-22(11-10-20-21(28)12-13-30-23(15)20)31-24(19-5-3-2-4-18(19)14-26)16-6-8-17(9-7-16)25(27)29/h2-11,24H,12-13H2,1H3,(H2,27,29)	BOJPRWQNICGYCH-UHFFFAOYSA-N	115104	(*R)-4-((2-cyanophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 61a	HLA-DR4 protein			 990							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115104&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			49790647	252664560							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135739	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2ccccc2C#N)ccc2c1OCCC2=O	InChI=1S/C25H20N2O4/c1-15-22(11-10-20-21(28)12-13-30-23(15)20)31-24(19-5-3-2-4-18(19)14-26)16-6-8-17(9-7-16)25(27)29/h2-11,24H,12-13H2,1H3,(H2,27,29)	BOJPRWQNICGYCH-UHFFFAOYSA-N	115105	(*S)-4-((2-cyanophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 61b	HLA-DR4 protein			 960							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115105&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5948348	252664561							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135740	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2ccc(Cl)cn2)ccc2c1OCCC2=O	InChI=1S/C23H19ClN2O4/c1-13-20(9-7-17-19(27)10-11-29-21(13)17)30-22(18-8-6-16(24)12-26-18)14-2-4-15(5-3-14)23(25)28/h2-9,12,22H,10-11H2,1H3,(H2,25,28)	ZFNBUKRTBIBNDR-UHFFFAOYSA-N	115106	(*R)-4-((5-chloropyridin-2-yl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 62a	HLA-DR4 protein			 1500							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115106&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			341914	252664562							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135741	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2ccc(Cl)cn2)ccc2c1OCCC2=O	InChI=1S/C23H19ClN2O4/c1-13-20(9-7-17-19(27)10-11-29-21(13)17)30-22(18-8-6-16(24)12-26-18)14-2-4-15(5-3-14)23(25)28/h2-9,12,22H,10-11H2,1H3,(H2,25,28)	ZFNBUKRTBIBNDR-UHFFFAOYSA-N	115107	(*S)-4-((5-chloropyridin-2-yl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 62b	HLA-DR4 protein			 1400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115107&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			360210	252664563							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135742	Cc1c(O[C@H](c2ccc(Cl)cc2)c2ccc(C(N)=O)cn2)ccc2c1OCCC2=O	InChI=1S/C23H19ClN2O4/c1-13-20(9-7-17-19(27)10-11-29-21(13)17)30-22(14-2-5-16(24)6-3-14)18-8-4-15(12-26-18)23(25)28/h2-9,12,22H,10-11H2,1H3,(H2,25,28)	DJMBDKCHGUGIFV-UHFFFAOYSA-N	115108	(*R)-6-((4-chlorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)nicotinamide::US12516038, Example 63a	HLA-DR4 protein			 1600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115108&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			53301193	252664564							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135743	Cc1c(O[C@@H](c2ccc(Cl)cc2)c2ccc(C(N)=O)cn2)ccc2c1OCCC2=O	InChI=1S/C23H19ClN2O4/c1-13-20(9-7-17-19(27)10-11-29-21(13)17)30-22(14-2-5-16(24)6-3-14)18-8-4-15(12-26-18)23(25)28/h2-9,12,22H,10-11H2,1H3,(H2,25,28)	DJMBDKCHGUGIFV-UHFFFAOYSA-N	115109	(*S)-6-((4-chlorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)nicotinamide::US12516038, Example 63b	HLA-DR4 protein			 1500							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115109&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			46907664	252664565							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135744	Cc1c(O[C@H](c2ccc(Cl)cc2)c2ccc(C(N)=O)nc2)ccc2c1OCCC2=O	InChI=1S/C23H19ClN2O4/c1-13-20(9-7-17-19(27)10-11-29-21(13)17)30-22(14-2-5-16(24)6-3-14)15-4-8-18(23(25)28)26-12-15/h2-9,12,22H,10-11H2,1H3,(H2,25,28)	BFZQVRLYYOBJRA-UHFFFAOYSA-N	115110	(*R)-5-((4-chlorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)picolinamide::US12516038, Example 64a	HLA-DR4 protein			 1700							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115110&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			53384869	252664566							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135745	Cc1c(O[C@@H](c2ccc(Cl)cc2)c2ccc(C(N)=O)nc2)ccc2c1OCCC2=O	InChI=1S/C23H19ClN2O4/c1-13-20(9-7-17-19(27)10-11-29-21(13)17)30-22(14-2-5-16(24)6-3-14)15-4-8-18(23(25)28)26-12-15/h2-9,12,22H,10-11H2,1H3,(H2,25,28)	BFZQVRLYYOBJRA-UHFFFAOYSA-N	115111	(*S)-5-((4-chlorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)picolinamide::US12516038, Example 64b	HLA-DR4 protein			 1800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115111&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			60156978	252664567							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135746	Cc3c(O[C@H](c1ccc(C(N)=O)cc1)c2cccc[n+]2[O-])ccc4C(=O)CCOc34	InChI=1S/C23H20N2O5/c1-14-20(10-9-17-19(26)11-13-29-21(14)17)30-22(18-4-2-3-12-25(18)28)15-5-7-16(8-6-15)23(24)27/h2-10,12,22H,11,13H2,1H3,(H2,24,27)	ZZKFRVCXUTYZAW-UHFFFAOYSA-N	115112	(*R)-2-((4-carbamoylphenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)pyridine 1-oxide::US12516038, Example 65a	HLA-DR4 protein			 30000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=115112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=115112&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			60158113	252664568							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135747	Cc3c(O[C@@H](c1ccc(C(N)=O)cc1)c2cccc[n+]2[O-])ccc4C(=O)CCOc34	InChI=1S/C23H20N2O5/c1-14-20(10-9-17-19(26)11-13-29-21(14)17)30-22(18-4-2-3-12-25(18)28)15-5-7-16(8-6-15)23(24)27/h2-10,12,22H,11,13H2,1H3,(H2,24,27)	ZZKFRVCXUTYZAW-UHFFFAOYSA-N	128202	(*S)-2-((4-carbamoylphenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)pyridine 1-oxide::US12516038, Example 65b	HLA-DR4 protein			 28000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128202&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			624350	225154546							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135748	Cc1c(O[C@@H](c2ccc(F)cc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H20FNO4/c1-14-21(11-10-19-20(27)12-13-29-22(14)19)30-23(16-6-8-18(25)9-7-16)15-2-4-17(5-3-15)24(26)28/h2-11,23H,12-13H2,1H3,(H2,26,28)	QMLBUWZADGUZMN-UHFFFAOYSA-N	128203	(*R)-4-((4-Fluorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 66a	HLA-DR4 protein			 2700							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128203&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			653280	252664613							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135749	Cc1c(O[C@H](c2ccc(F)cc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H20FNO4/c1-14-21(11-10-19-20(27)12-13-29-22(14)19)30-23(16-6-8-18(25)9-7-16)15-2-4-17(5-3-15)24(26)28/h2-11,23H,12-13H2,1H3,(H2,26,28)	QMLBUWZADGUZMN-UHFFFAOYSA-N	128204	(*S)-4-((4-Fluorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 66b	HLA-DR4 protein			 2400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128204	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128204&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			660340	225154547							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135750	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2cccc(F)c2)ccc2c1OCCC2=O	InChI=1S/C24H20FNO4/c1-14-21(10-9-19-20(27)11-12-29-22(14)19)30-23(17-3-2-4-18(25)13-17)15-5-7-16(8-6-15)24(26)28/h2-10,13,23H,11-12H2,1H3,(H2,26,28)	NHPGULDJTHPDIZ-UHFFFAOYSA-N	128205	(*R)-4-((3-Fluorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 67a	HLA-DR4 protein			 3100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128205&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			662624	225154548							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135751	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2cccc(F)c2)ccc2c1OCCC2=O	InChI=1S/C24H20FNO4/c1-14-21(10-9-19-20(27)11-12-29-22(14)19)30-23(17-3-2-4-18(25)13-17)15-5-7-16(8-6-15)24(26)28/h2-10,13,23H,11-12H2,1H3,(H2,26,28)	NHPGULDJTHPDIZ-UHFFFAOYSA-N	128206	(*S)-4-((3-Fluorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 67b	HLA-DR4 protein			 2200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128206&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5308164	225154549							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135752	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2ccccc2F)ccc2c1OCCC2=O	InChI=1S/C24H20FNO4/c1-14-21(11-10-18-20(27)12-13-29-22(14)18)30-23(17-4-2-3-5-19(17)25)15-6-8-16(9-7-15)24(26)28/h2-11,23H,12-13H2,1H3,(H2,26,28)	YXIKVGYCCZPAIJ-UHFFFAOYSA-N	128207	(*R)-4-((2-Fluorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 68a	HLA-DR4 protein			 1500							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128207&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2249389	225154550							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135753	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2ccccc2F)ccc2c1OCCC2=O	InChI=1S/C24H20FNO4/c1-14-21(11-10-18-20(27)12-13-29-22(14)18)30-23(17-4-2-3-5-19(17)25)15-6-8-16(9-7-15)24(26)28/h2-11,23H,12-13H2,1H3,(H2,26,28)	YXIKVGYCCZPAIJ-UHFFFAOYSA-N	128208	(*S)-4-((2-Fluorophenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 68b	HLA-DR4 protein			 5400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128208&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			802846	225154551							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135754	Cc1c(O[C@H](c2ccccc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H21NO4/c1-15-21(12-11-19-20(26)13-14-28-22(15)19)29-23(16-5-3-2-4-6-16)17-7-9-18(10-8-17)24(25)27/h2-12,23H,13-14H2,1H3,(H2,25,27)	KIKVZABFWUJIGA-UHFFFAOYSA-N	128209	(*R)-4-(((8-Methyl-4-oxochroman-7-yl)oxy)(phenyl)methyl)benzamide::US12516038, Example 69a	HLA-DR4 protein			 2100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128209&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			9563602	225154552							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135755	Cc1c(O[C@@H](c2ccccc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H21NO4/c1-15-21(12-11-19-20(26)13-14-28-22(15)19)29-23(16-5-3-2-4-6-16)17-7-9-18(10-8-17)24(25)27/h2-12,23H,13-14H2,1H3,(H2,25,27)	KIKVZABFWUJIGA-UHFFFAOYSA-N	128210	(*S)-4-(((8-Methyl-4-oxochroman-7-yl)oxy)(phenyl)methyl)benzamide::US12516038, Example 69b	HLA-DR4 protein			 2100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128210&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			725789	225154553							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135756	Cc1c(O[C@H](c2ccccc2)c2ccc(C(=O)O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H20O5/c1-15-21(12-11-19-20(25)13-14-28-22(15)19)29-23(16-5-3-2-4-6-16)17-7-9-18(10-8-17)24(26)27/h2-12,23H,13-14H2,1H3,(H,26,27)	XKDCHBZQYRWEMX-UHFFFAOYSA-N	128211	(*R)-4-(((8-methyl-4-oxochroman-7-yl)oxy)(phenyl)methyl)benzoic acid::US12516038, Example 70a	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128211	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128211&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2895747	225154554							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135757	Cc1c(O[C@@H](c2ccccc2)c2ccc(C(=O)O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H20O5/c1-15-21(12-11-19-20(25)13-14-28-22(15)19)29-23(16-5-3-2-4-6-16)17-7-9-18(10-8-17)24(26)27/h2-12,23H,13-14H2,1H3,(H,26,27)	XKDCHBZQYRWEMX-UHFFFAOYSA-N	128212	(*S)-4-(((8-methyl-4-oxochroman-7-yl)oxy)(phenyl)methyl)benzoic acid::US12516038, Example 70b	HLA-DR4 protein			 1500							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128212&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			1249904	225154555							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135758	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2ccc(C(=O)O)cc2)ccc2c1OCCC2=O	InChI=1S/C25H21NO6/c1-14-21(11-10-19-20(27)12-13-31-22(14)19)32-23(15-2-6-17(7-3-15)24(26)28)16-4-8-18(9-5-16)25(29)30/h2-11,23H,12-13H2,1H3,(H2,26,28)(H,29,30)	NJMICKXOAVVABF-UHFFFAOYSA-N	128213	(*R)-4-((4-carbamoylphenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzoic acid::US12516038, Example 71a	HLA-DR4 protein			 1600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128213&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5412241	225154556							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135759	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2ccc(C(=O)O)cc2)ccc2c1OCCC2=O	InChI=1S/C25H21NO6/c1-14-21(11-10-19-20(27)12-13-31-22(14)19)32-23(15-2-6-17(7-3-15)24(26)28)16-4-8-18(9-5-16)25(29)30/h2-11,23H,12-13H2,1H3,(H2,26,28)(H,29,30)	NJMICKXOAVVABF-UHFFFAOYSA-N	128214	(*S)-4-((4-carbamoylphenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzoic acid::US12516038, Example 71b	HLA-DR4 protein			 930							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128214	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128214&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			11841141	225154557							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135760	CN(C)C(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C24H22N2O4/c1-26(2)24(28)18-5-3-16(4-6-18)23(17-9-12-25-13-10-17)30-19-7-8-20-21(27)11-14-29-22(20)15-19/h3-10,12-13,15,23H,11,14H2,1-2H3	QMDMNPXTGSBNKV-UHFFFAOYSA-N	128215	(*R)—N,N-dimethyl-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 72a	HLA-DR4 protein			 840							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128215&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			919914	225154558							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135761	CN(C)C(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C24H22N2O4/c1-26(2)24(28)18-5-3-16(4-6-18)23(17-9-12-25-13-10-17)30-19-7-8-20-21(27)11-14-29-22(20)15-19/h3-10,12-13,15,23H,11,14H2,1-2H3	QMDMNPXTGSBNKV-UHFFFAOYSA-N	128216	(*S)—N,N-dimethyl-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 72b	HLA-DR4 protein			 690							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128216&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			2185046	225154559							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135762	CCc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H22N2O4/c1-2-18-21(8-7-19-20(27)11-14-29-23(18)19)30-22(16-9-12-26-13-10-16)15-3-5-17(6-4-15)24(25)28/h3-10,12-13,22H,2,11,14H2,1H3,(H2,25,28)	CXRJVRUDUGJYDS-UHFFFAOYSA-N	128217	(*R)-4-(((8-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 73a	HLA-DR4 protein			 540							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128217&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			12004547	225154560							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135763	CCc1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C24H22N2O4/c1-2-18-21(8-7-19-20(27)11-14-29-23(18)19)30-22(16-9-12-26-13-10-16)15-3-5-17(6-4-15)24(25)28/h3-10,12-13,22H,2,11,14H2,1H3,(H2,25,28)	CXRJVRUDUGJYDS-UHFFFAOYSA-N	128218	(*S)-4-(((8-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 73b	HLA-DR4 protein			 600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128218&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5399944	225154561							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135764	CCc1cc2c(cc1O[C@@H](c1ccncc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C24H22N2O4/c1-2-15-13-19-20(27)9-12-29-22(19)14-21(15)30-23(17-7-10-26-11-8-17)16-3-5-18(6-4-16)24(25)28/h3-8,10-11,13-14,23H,2,9,12H2,1H3,(H2,25,28)	KTLQZJCDFXKFGW-UHFFFAOYSA-N	128219	(*R)-4-(((6-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 74a	HLA-DR4 protein			 550							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128219&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3814317	225154562							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135765	CCc1cc2c(cc1O[C@H](c1ccncc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C24H22N2O4/c1-2-15-13-19-20(27)9-12-29-22(19)14-21(15)30-23(17-7-10-26-11-8-17)16-3-5-18(6-4-16)24(25)28/h3-8,10-11,13-14,23H,2,9,12H2,1H3,(H2,25,28)	KTLQZJCDFXKFGW-UHFFFAOYSA-N	128220	(*S)-4-(((6-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 74b	HLA-DR4 protein			 920							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128220	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128220&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			4681574	225154563							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135766	CC(C)c1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C25H24N2O4/c1-15(2)22-21(8-7-19-20(28)11-14-30-24(19)22)31-23(17-9-12-27-13-10-17)16-3-5-18(6-4-16)25(26)29/h3-10,12-13,15,23H,11,14H2,1-2H3,(H2,26,29)	MLDSFHUVMNKFFF-UHFFFAOYSA-N	128221	(*R)-4-(((8-isopropyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 75a	HLA-DR4 protein			 600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128221&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			1225706	225154564							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135767	CC(C)c1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C25H24N2O4/c1-15(2)22-21(8-7-19-20(28)11-14-30-24(19)22)31-23(17-9-12-27-13-10-17)16-3-5-18(6-4-16)25(26)29/h3-10,12-13,15,23H,11,14H2,1-2H3,(H2,26,29)	MLDSFHUVMNKFFF-UHFFFAOYSA-N	128222	(*S)-4-(((8-isopropyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 75b	HLA-DR4 protein			 630							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128222&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			903405	225154565							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135768	CC(C)c1cc2c(cc1O[C@@H](c1ccncc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C25H24N2O4/c1-15(2)19-13-20-21(28)9-12-30-22(20)14-23(19)31-24(17-7-10-27-11-8-17)16-3-5-18(6-4-16)25(26)29/h3-8,10-11,13-15,24H,9,12H2,1-2H3,(H2,26,29)	FRSJBRWQEVCPRJ-UHFFFAOYSA-N	128223	(*R)-4-(((6-isopropyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 76a	HLA-DR4 protein			 650							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128223&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			903067	225154566							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135769	CC(C)c1cc2c(cc1O[C@H](c1ccncc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C25H24N2O4/c1-15(2)19-13-20-21(28)9-12-30-22(20)14-23(19)31-24(17-7-10-27-11-8-17)16-3-5-18(6-4-16)25(26)29/h3-8,10-11,13-15,24H,9,12H2,1-2H3,(H2,26,29)	FRSJBRWQEVCPRJ-UHFFFAOYSA-N	128224	(*S)-4-(((6-isopropyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 76b	HLA-DR4 protein			 1000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128224&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			844287	225154567							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135770	COc1cc(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)cc2c1C(=O)CCO2	InChI=1S/C23H20N2O5/c1-28-19-12-17(13-20-21(19)18(26)8-11-29-20)30-22(15-6-9-25-10-7-15)14-2-4-16(5-3-14)23(24)27/h2-7,9-10,12-13,22H,8,11H2,1H3,(H2,24,27)	AADRZQPRQHKACJ-UHFFFAOYSA-N	128225	(*R)-4-(((5-methoxy-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 77a	HLA-DR4 protein			 1700							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128225&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			75668684	225154568							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135771	COc1cc(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2)cc2c1C(=O)CCO2	InChI=1S/C23H20N2O5/c1-28-19-12-17(13-20-21(19)18(26)8-11-29-20)30-22(15-6-9-25-10-7-15)14-2-4-16(5-3-14)23(24)27/h2-7,9-10,12-13,22H,8,11H2,1H3,(H2,24,27)	AADRZQPRQHKACJ-UHFFFAOYSA-N	128226	(*S)-4-(((5-methoxy-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 77b	HLA-DR4 protein			 1500							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128226	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128226&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			540145	225154569							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135772	N#Cc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C23H17N3O4/c24-13-18-20(6-5-17-19(27)9-12-29-22(17)18)30-21(15-7-10-26-11-8-15)14-1-3-16(4-2-14)23(25)28/h1-8,10-11,21H,9,12H2,(H2,25,28)	ANWUXBHHKSBTLT-UHFFFAOYSA-N	128227	(*R)-4-(((8-cyano-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 78a	HLA-DR4 protein			 470							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128227	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128227&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			6404717	225154570							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135773	N#Cc1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C23H17N3O4/c24-13-18-20(6-5-17-19(27)9-12-29-22(17)18)30-21(15-7-10-26-11-8-15)14-1-3-16(4-2-14)23(25)28/h1-8,10-11,21H,9,12H2,(H2,25,28)	ANWUXBHHKSBTLT-UHFFFAOYSA-N	128228	(*S)-4-(((8-cyano-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 78b	HLA-DR4 protein			 450							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128228	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128228&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			16195927	225154571							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135774	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2-c2ccc(-c4ccccc4)cc2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C34H26N2O4/c35-34(38)27-12-10-25(11-13-27)32(26-16-19-36-20-17-26)40-30-15-14-28-29(37)18-21-39-33(28)31(30)24-8-6-23(7-9-24)22-4-2-1-3-5-22/h1-17,19-20,32H,18,21H2,(H2,35,38)	HZBPQJWALVXSEF-UHFFFAOYSA-N	128229	(*R)-4-(((8-([1,1'-biphenyl]-4-yl)-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 79a	HLA-DR4 protein			 28000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128229&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			4882475	225154572							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135775	NC(=O)c1ccc([C@H](Oc2ccc3c(c2-c2ccc(-c4ccccc4)cc2)OCCC3=O)c2ccncc2)cc1	InChI=1S/C34H26N2O4/c35-34(38)27-12-10-25(11-13-27)32(26-16-19-36-20-17-26)40-30-15-14-28-29(37)18-21-39-33(28)31(30)24-8-6-23(7-9-24)22-4-2-1-3-5-22/h1-17,19-20,32H,18,21H2,(H2,35,38)	HZBPQJWALVXSEF-UHFFFAOYSA-N	128230	(*S)-4-(((8-([1,1'-biphenyl]-4-yl)-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 79b	HLA-DR4 protein			 49000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128230	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128230&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			699740	225154573							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135776	CCCc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C25H24N2O4/c1-2-3-20-22(9-8-19-21(28)12-15-30-24(19)20)31-23(17-10-13-27-14-11-17)16-4-6-18(7-5-16)25(26)29/h4-11,13-14,23H,2-3,12,15H2,1H3,(H2,26,29)	PJXVCOXXTBTTOQ-UHFFFAOYSA-N	128231	(*R)-4-(((4-Oxo-8-propylchroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 80a	HLA-DR4 protein			 660							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128231&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3815572	225154574							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135777	CCCc1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C25H24N2O4/c1-2-3-20-22(9-8-19-21(28)12-15-30-24(19)20)31-23(17-10-13-27-14-11-17)16-4-6-18(7-5-16)25(26)29/h4-11,13-14,23H,2-3,12,15H2,1H3,(H2,26,29)	PJXVCOXXTBTTOQ-UHFFFAOYSA-N	128232	(*S)-4-(((4-Oxo-8-propylchroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 80b	HLA-DR4 protein			 960							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128232&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			1221653	225154575							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135778	Cc1c(O[C@@H](c2ccncc2)c2cccc(CNC(N)=O)c2)ccc2c1OCCC2=O	InChI=1S/C24H23N3O4/c1-15-21(6-5-19-20(28)9-12-30-22(15)19)31-23(17-7-10-26-11-8-17)18-4-2-3-16(13-18)14-27-24(25)29/h2-8,10-11,13,23H,9,12,14H2,1H3,(H3,25,27,29)	HLTJOKQTXZIKKT-UHFFFAOYSA-N	128233	(*R)-1-(3-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzyl)urea::US12516038, Example 81a	HLA-DR4 protein			 690							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128233&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			54677751	225154576							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135779	Cc1c(O[C@H](c2ccncc2)c2cccc(CNC(N)=O)c2)ccc2c1OCCC2=O	InChI=1S/C24H23N3O4/c1-15-21(6-5-19-20(28)9-12-30-22(15)19)31-23(17-7-10-26-11-8-17)18-4-2-3-16(13-18)14-27-24(25)29/h2-8,10-11,13,23H,9,12,14H2,1H3,(H3,25,27,29)	HLTJOKQTXZIKKT-UHFFFAOYSA-N	128234	(*S)-1-(3-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzyl)urea::US12516038, Example 81b	HLA-DR4 protein			 610							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128234	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128234&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			5338790	225154577							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135780	COc1cc(C(N)=O)ccc1[C@H](Oc1ccc2c(c1C)OCCC2=O)c1ccncc1	InChI=1S/C24H22N2O5/c1-14-20(6-5-17-19(27)9-12-30-22(14)17)31-23(15-7-10-26-11-8-15)18-4-3-16(24(25)28)13-21(18)29-2/h3-8,10-11,13,23H,9,12H2,1-2H3,(H2,25,28)	NNRJKIVVDKQNKB-UHFFFAOYSA-N	128235	(*R)-3-Methoxy-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 82a	HLA-DR4 protein			 710							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128235&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			3781244	225154578							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135781	COc1cc(C(N)=O)ccc1[C@@H](Oc1ccc2c(c1C)OCCC2=O)c1ccncc1	InChI=1S/C24H22N2O5/c1-14-20(6-5-17-19(27)9-12-30-22(14)17)31-23(15-7-10-26-11-8-15)18-4-3-16(24(25)28)13-21(18)29-2/h3-8,10-11,13,23H,9,12H2,1-2H3,(H2,25,28)	NNRJKIVVDKQNKB-UHFFFAOYSA-N	128236	(*S)-3-Methoxy-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 82b	HLA-DR4 protein			 620							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128236	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128236&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			4962642	252664614							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135782	CCOc1cc(C(N)=O)ccc1[C@H](Oc1ccc2c(c1C)OCCC2=O)c1ccncc1	InChI=1S/C25H24N2O5/c1-3-30-22-14-17(25(26)29)4-5-19(22)24(16-8-11-27-12-9-16)32-21-7-6-18-20(28)10-13-31-23(18)15(21)2/h4-9,11-12,14,24H,3,10,13H2,1-2H3,(H2,26,29)	XZPUIKSKGZIPBT-UHFFFAOYSA-N	128237	(*R)-3-ethoxy-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 83a	HLA-DR4 protein			 950							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128237	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128237&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			74687657	225154579							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135783	CCOc1cc(C(N)=O)ccc1[C@@H](Oc1ccc2c(c1C)OCCC2=O)c1ccncc1	InChI=1S/C25H24N2O5/c1-3-30-22-14-17(25(26)29)4-5-19(22)24(16-8-11-27-12-9-16)32-21-7-6-18-20(28)10-13-31-23(18)15(21)2/h4-9,11-12,14,24H,3,10,13H2,1-2H3,(H2,26,29)	XZPUIKSKGZIPBT-UHFFFAOYSA-N	128238	(*S)-3-ethoxy-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 83b	HLA-DR4 protein			 690							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128238	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128238&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			86766748	225154580							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135784	Cc1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2OC(C)C)ccc2c1OCCC2=O	InChI=1S/C26H26N2O5/c1-15(2)32-23-14-18(26(27)30)4-5-20(23)25(17-8-11-28-12-9-17)33-22-7-6-19-21(29)10-13-31-24(19)16(22)3/h4-9,11-12,14-15,25H,10,13H2,1-3H3,(H2,27,30)	DLWLDYVYFAYBDI-UHFFFAOYSA-N	128239	(*R)-3-isopropoxy-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 84a	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128239&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24792918	225154581							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135785	Cc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2OC(C)C)ccc2c1OCCC2=O	InChI=1S/C26H26N2O5/c1-15(2)32-23-14-18(26(27)30)4-5-20(23)25(17-8-11-28-12-9-17)33-22-7-6-19-21(29)10-13-31-24(19)16(22)3/h4-9,11-12,14-15,25H,10,13H2,1-3H3,(H2,27,30)	DLWLDYVYFAYBDI-UHFFFAOYSA-N	128240	(*S)-3-isopropoxy-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 84b	HLA-DR4 protein			<1000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128240	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128240&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24817766	225154582							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135786	Cc1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2OCC(C)C)ccc2c1OCCC2=O	InChI=1S/C27H28N2O5/c1-16(2)15-33-24-14-19(27(28)31)4-5-21(24)26(18-8-11-29-12-9-18)34-23-7-6-20-22(30)10-13-32-25(20)17(23)3/h4-9,11-12,14,16,26H,10,13,15H2,1-3H3,(H2,28,31)	RNWJPRIFGJVQOF-UHFFFAOYSA-N	128241	(*R)-3-isobutoxy-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 85a	HLA-DR4 protein			 810							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128241&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			24856208	225154583							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135787	Cc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2OCC(C)C)ccc2c1OCCC2=O	InChI=1S/C27H28N2O5/c1-16(2)15-33-24-14-19(27(28)31)4-5-21(24)26(18-8-11-29-12-9-18)34-23-7-6-20-22(30)10-13-32-25(20)17(23)3/h4-9,11-12,14,16,26H,10,13,15H2,1-3H3,(H2,28,31)	RNWJPRIFGJVQOF-UHFFFAOYSA-N	128242	(*S)-3-isobutoxy-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 85b	HLA-DR4 protein			 1100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128242	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128242&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			25102606	225154584							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135788	Cc1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2OCc2ccccc2)ccc2c1OCCC2=O	InChI=1S/C30H26N2O5/c1-19-26(10-9-23-25(33)13-16-35-28(19)23)37-29(21-11-14-32-15-12-21)24-8-7-22(30(31)34)17-27(24)36-18-20-5-3-2-4-6-20/h2-12,14-15,17,29H,13,16,18H2,1H3,(H2,31,34)	XZURHHCSLJXEEC-UHFFFAOYSA-N	128243	(*R)-3-(benzyloxy)-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 86a	HLA-DR4 protein			 740							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128243	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128243&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			227091	225154585							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135789	Cc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2OCc2ccccc2)ccc2c1OCCC2=O	InChI=1S/C30H26N2O5/c1-19-26(10-9-23-25(33)13-16-35-28(19)23)37-29(21-11-14-32-15-12-21)24-8-7-22(30(31)34)17-27(24)36-18-20-5-3-2-4-6-20/h2-12,14-15,17,29H,13,16,18H2,1H3,(H2,31,34)	XZURHHCSLJXEEC-UHFFFAOYSA-N	128244	(*S)-3-(benzyloxy)-4-(((8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 86b	HLA-DR4 protein			 1000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128244	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128244&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			46903185	225154586							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135790	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2ccnc(CCC(=O)O)c2)ccc2c1OCCC2=O	InChI=1S/C26H24N2O6/c1-15-22(8-7-20-21(29)11-13-33-24(15)20)34-25(16-2-4-17(5-3-16)26(27)32)18-10-12-28-19(14-18)6-9-23(30)31/h2-5,7-8,10,12,14,25H,6,9,11,13H2,1H3,(H2,27,32)(H,30,31)	CCUYQOBXAXUGLY-UHFFFAOYSA-N	128245	(*R)-Ethyl 3-(4-((4-carbamoylphenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)pyridin-2-yl)propanoate::US12516038, Example 87a	HLA-DR4 protein			 580							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=128245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=128245&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			60157353	225154587							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135791	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2ccnc(CCC(=O)O)c2)ccc2c1OCCC2=O	InChI=1S/C26H24N2O6/c1-15-22(8-7-20-21(29)11-13-33-24(15)20)34-25(16-2-4-17(5-3-16)26(27)32)18-10-12-28-19(14-18)6-9-23(30)31/h2-5,7-8,10,12,14,25H,6,9,11,13H2,1H3,(H2,27,32)(H,30,31)	CCUYQOBXAXUGLY-UHFFFAOYSA-N	177692	(*S)-Ethyl 3-(4-((4-carbamoylphenyl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)pyridin-2-yl)propanoate::US12516038, Example 87b	HLA-DR4 protein			 510							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=177692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=177692&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118987157	313048200							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135792	Cc1cc2c(c(C)c1O[C@@H](c1ccncc1)c1ccc(C#N)cc1)OCCC2=O	InChI=1S/C24H20N2O3/c1-15-13-20-21(27)9-12-28-23(20)16(2)22(15)29-24(19-7-10-26-11-8-19)18-5-3-17(14-25)4-6-18/h3-8,10-11,13,24H,9,12H2,1-2H3	DPSZTCDRSPHJOE-UHFFFAOYSA-N	177693	(*R)-4-(((6,8-dimethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzonitrile::US12516038, Example 88a	HLA-DR4 protein			 400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=177693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=177693&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118987158	313048201							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135793	Cc1cc2c(c(C)c1O[C@H](c1ccncc1)c1ccc(C#N)cc1)OCCC2=O	InChI=1S/C24H20N2O3/c1-15-13-20-21(27)9-12-28-23(20)16(2)22(15)29-24(19-7-10-26-11-8-19)18-5-3-17(14-25)4-6-18/h3-8,10-11,13,24H,9,12H2,1-2H3	DPSZTCDRSPHJOE-UHFFFAOYSA-N	177694	(*S)-4-(((6,8-dimethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzonitrile::US12516038, Example 88b	HLA-DR4 protein			 360							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=177694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=177694&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118987159	313048202							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135794	Cc1cc2c(c(C)c1O[C@@H](c1ccncc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C24H22N2O4/c1-14-13-19-20(27)9-12-29-22(19)15(2)21(14)30-23(17-7-10-26-11-8-17)16-3-5-18(6-4-16)24(25)28/h3-8,10-11,13,23H,9,12H2,1-2H3,(H2,25,28)	YTNHKCDRUDLMFP-UHFFFAOYSA-N	188488	(*R)-4-(((6,8-dimethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 89a	HLA-DR4 protein			 470							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=188488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=188488&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			96368	316606119							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135795	Cc1cc2c(c(C)c1O[C@H](c1ccncc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C24H22N2O4/c1-14-13-19-20(27)9-12-29-22(19)15(2)21(14)30-23(17-7-10-26-11-8-17)16-3-5-18(6-4-16)24(25)28/h3-8,10-11,13,23H,9,12H2,1-2H3,(H2,25,28)	YTNHKCDRUDLMFP-UHFFFAOYSA-N	190890	(*S)-4-(((6,8-dimethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 89b	HLA-DR4 protein			 470							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190890&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159281	316936160							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135796	Cc1cc2c(c(C)c1O[C@@H](c1ccc(F)cc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C25H22FNO4/c1-14-13-20-21(28)11-12-30-23(20)15(2)22(14)31-24(17-7-9-19(26)10-8-17)16-3-5-18(6-4-16)25(27)29/h3-10,13,24H,11-12H2,1-2H3,(H2,27,29)	UROILWHEKNHCQG-UHFFFAOYSA-N	190891	(*R)-4-(((6,8-dimethyl-4-oxochroman-7-yl)oxy)(4-fluorophenyl)methyl)benzamide::US12516038, Example 90a	HLA-DR4 protein			 520							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190891&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159376	316936161							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135797	Cc1cc2c(c(C)c1O[C@H](c1ccc(F)cc1)c1ccc(C(N)=O)cc1)OCCC2=O	InChI=1S/C25H22FNO4/c1-14-13-20-21(28)11-12-30-23(20)15(2)22(14)31-24(17-7-9-19(26)10-8-17)16-3-5-18(6-4-16)25(27)29/h3-10,13,24H,11-12H2,1-2H3,(H2,27,29)	UROILWHEKNHCQG-UHFFFAOYSA-N	190892	(*S)-4-(((6,8-dimethyl-4-oxochroman-7-yl)oxy)(4-fluorophenyl)methyl)benzamide::US12516038, Example 90b	HLA-DR4 protein			 590							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190892&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159255	316936162							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135798	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2ccc(F)c(F)c2)c(F)cc2c1OCCC2=O	InChI=1S/C24H18F3NO4/c1-12-21-16(20(29)8-9-31-21)11-19(27)22(12)32-23(15-6-7-17(25)18(26)10-15)13-2-4-14(5-3-13)24(28)30/h2-7,10-11,23H,8-9H2,1H3,(H2,28,30)	ZEOCATLHGFKONM-UHFFFAOYSA-N	190893	(*R)-4-((3,4-difluorophenyl)((6-fluoro-8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 91a	HLA-DR4 protein			 550							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190893&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159334	316936163							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135799	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2ccc(F)c(F)c2)c(F)cc2c1OCCC2=O	InChI=1S/C24H18F3NO4/c1-12-21-16(20(29)8-9-31-21)11-19(27)22(12)32-23(15-6-7-17(25)18(26)10-15)13-2-4-14(5-3-13)24(28)30/h2-7,10-11,23H,8-9H2,1H3,(H2,28,30)	ZEOCATLHGFKONM-UHFFFAOYSA-N	190894	US12516038, Example 91b	HLA-DR4 protein			 350							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190894&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159231	316936164							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135800	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2cccc(C#N)c2)c(F)cc2c1OCCC2=O	InChI=1S/C25H19FN2O4/c1-14-22-19(21(29)9-10-31-22)12-20(26)23(14)32-24(18-4-2-3-15(11-18)13-27)16-5-7-17(8-6-16)25(28)30/h2-8,11-12,24H,9-10H2,1H3,(H2,28,30)	CFVMMIVRLUGZIV-UHFFFAOYSA-N	190895	(*R)-4-((3-cyanophenyl)((6-fluoro-8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 92a	HLA-DR4 protein			 300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190895&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159267	316936165							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135801	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2cccc(C#N)c2)c(F)cc2c1OCCC2=O	InChI=1S/C25H19FN2O4/c1-14-22-19(21(29)9-10-31-22)12-20(26)23(14)32-24(18-4-2-3-15(11-18)13-27)16-5-7-17(8-6-16)25(28)30/h2-8,11-12,24H,9-10H2,1H3,(H2,28,30)	CFVMMIVRLUGZIV-UHFFFAOYSA-N	190896	US12516038, Example 92b	HLA-DR4 protein			 190							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190896&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159242	316936166							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135802	Cc1c(O[C@H](c2ccc(C(N)=O)cc2)c2ccc(S(C)(=O)=O)cc2)c(F)cc2c1OCCC2=O	InChI=1S/C25H22FNO6S/c1-14-22-19(21(28)11-12-32-22)13-20(26)23(14)33-24(15-3-5-17(6-4-15)25(27)29)16-7-9-18(10-8-16)34(2,30)31/h3-10,13,24H,11-12H2,1-2H3,(H2,27,29)	BNMKFEJGKLBZQM-UHFFFAOYSA-N	190897	US12516038, Example 93a	HLA-DR4 protein			 190							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190897&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159339	316936167							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135803	Cc1c(O[C@@H](c2ccc(C(N)=O)cc2)c2ccc(S(C)(=O)=O)cc2)c(F)cc2c1OCCC2=O	InChI=1S/C25H22FNO6S/c1-14-22-19(21(28)11-12-32-22)13-20(26)23(14)33-24(15-3-5-17(6-4-15)25(27)29)16-7-9-18(10-8-16)34(2,30)31/h3-10,13,24H,11-12H2,1-2H3,(H2,27,29)	BNMKFEJGKLBZQM-UHFFFAOYSA-N	190898	US12516038, Example 93b	HLA-DR4 protein			 280							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190898&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159331	316936168							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135804	Cc1cc([C@H](Oc2c(F)cc3c(c2C)OCCC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C25H23FN2O4/c1-13-10-18(11-14(2)28-13)24(16-4-6-17(7-5-16)25(27)30)32-23-15(3)22-19(12-20(23)26)21(29)8-9-31-22/h4-7,10-12,24H,8-9H2,1-3H3,(H2,27,30)	OJRZTSKZXQFIAQ-UHFFFAOYSA-N	190899	US12516038, Example 94a	HLA-DR4 protein			 220							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190899&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159392	316936169							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135805	Cc1cc([C@@H](Oc2c(F)cc3c(c2C)OCCC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C25H23FN2O4/c1-13-10-18(11-14(2)28-13)24(16-4-6-17(7-5-16)25(27)30)32-23-15(3)22-19(12-20(23)26)21(29)8-9-31-22/h4-7,10-12,24H,8-9H2,1-3H3,(H2,27,30)	OJRZTSKZXQFIAQ-UHFFFAOYSA-N	190900	US12516038, Example 94b	HLA-DR4 protein			 230							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190900&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159315	316936170							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135806	Cc1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)c(F)c2)c(F)cc2c1OCCC2=O	InChI=1S/C23H18F2N2O4/c1-12-20-16(19(28)6-9-30-20)11-18(25)21(12)31-22(13-4-7-27-8-5-13)14-2-3-15(23(26)29)17(24)10-14/h2-5,7-8,10-11,22H,6,9H2,1H3,(H2,26,29)	FEIMPSDFSUCYFK-UHFFFAOYSA-N	190903	(*R)-2-fluoro-4-(((6-fluoro-8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 95a	HLA-DR4 protein			 220							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190903&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118180374	316936171							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135807	Cc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)c(F)c2)c(F)cc2c1OCCC2=O	InChI=1S/C23H18F2N2O4/c1-12-20-16(19(28)6-9-30-20)11-18(25)21(12)31-22(13-4-7-27-8-5-13)14-2-3-15(23(26)29)17(24)10-14/h2-5,7-8,10-11,22H,6,9H2,1H3,(H2,26,29)	FEIMPSDFSUCYFK-UHFFFAOYSA-N	190904	(*S)-2-fluoro-4-(((6-fluoro-8-methyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 95b	HLA-DR4 protein			 220							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190904&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159221	316936172							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135808	Cc1c(O[C@H](c2ccncc2)c2cccc(F)c2)c(F)cc2c1OCCC2=O	InChI=1S/C22H17F2NO3/c1-13-20-17(19(26)7-10-27-20)12-18(24)21(13)28-22(14-5-8-25-9-6-14)15-3-2-4-16(23)11-15/h2-6,8-9,11-12,22H,7,10H2,1H3	PEFZUMJMOMIRMX-UHFFFAOYSA-N	190905	(*R)-6-fluoro-7-((3-fluorophenyl)(pyridin-4-yl)methoxy)-8-methylchroman-4-one::US12516038, Example 96a	HLA-DR4 protein			 300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190905&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159203	316936173							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135809	Cc1c(O[C@@H](c2ccncc2)c2cccc(F)c2)c(F)cc2c1OCCC2=O	InChI=1S/C22H17F2NO3/c1-13-20-17(19(26)7-10-27-20)12-18(24)21(13)28-22(14-5-8-25-9-6-14)15-3-2-4-16(23)11-15/h2-6,8-9,11-12,22H,7,10H2,1H3	PEFZUMJMOMIRMX-UHFFFAOYSA-N	190906	(*S)-6-fluoro-7-((3-fluorophenyl)(pyridin-4-yl)methoxy)-8-methylchroman-4-one::US12516038, Example 96b	HLA-DR4 protein			 470							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190906&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159337	316936174							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135810	COc1ccc([C@H](Oc2c(F)cc3c(c2C)OCCC3=O)c2ccncc2)cc1F	InChI=1S/C23H19F2NO4/c1-13-21-16(19(27)7-10-29-21)12-18(25)22(13)30-23(14-5-8-26-9-6-14)15-3-4-20(28-2)17(24)11-15/h3-6,8-9,11-12,23H,7,10H2,1-2H3	XNDPZGNJEKXEJW-UHFFFAOYSA-N	190907	(*R)-6-fluoro-7-((3-fluoro-4-methoxyphenyl)(pyridin-4-yl)methoxy)-8-methylchroman-4-one::US12516038, Example 97a	HLA-DR4 protein			 410							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190907&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159320	316936175							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135811	COc1ccc([C@@H](Oc2c(F)cc3c(c2C)OCCC3=O)c2ccncc2)cc1F	InChI=1S/C23H19F2NO4/c1-13-21-16(19(27)7-10-29-21)12-18(25)22(13)30-23(14-5-8-26-9-6-14)15-3-4-20(28-2)17(24)11-15/h3-6,8-9,11-12,23H,7,10H2,1-2H3	XNDPZGNJEKXEJW-UHFFFAOYSA-N	190908	(*S)-6-fluoro-7-((3-fluoro-4-methoxyphenyl)(pyridin-4-yl)methoxy)-8-methylchroman-4-one::US12516038, Example 97b	HLA-DR4 protein			 380							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190908&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159386	316936176							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135812	NC(=O)c1ccc([C@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)c2ccccc12	InChI=1S/C26H20N2O4/c27-26(30)21-8-7-20(18-3-1-2-4-19(18)21)25(16-9-12-28-13-10-16)32-17-5-6-22-23(29)11-14-31-24(22)15-17/h1-10,12-13,15,25H,11,14H2,(H2,27,30)	SVWWHQDPJWMKHA-UHFFFAOYSA-N	190909	(*R)-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)-1-naphthamide::US12516038, Example 98a	HLA-DR4 protein			 9000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190909&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159302	316936177							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135813	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2)OCCC3=O)c2ccncc2)c2ccccc12	InChI=1S/C26H20N2O4/c27-26(30)21-8-7-20(18-3-1-2-4-19(18)21)25(16-9-12-28-13-10-16)32-17-5-6-22-23(29)11-14-31-24(22)15-17/h1-10,12-13,15,25H,11,14H2,(H2,27,30)	SVWWHQDPJWMKHA-UHFFFAOYSA-N	190910	(*S)-4-(((4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)-1-naphthamide::US12516038, Example 98b	HLA-DR4 protein			 10000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190910&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159371	316936178							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135814	CCc1cc(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)cc2c1C(=O)CCO2	InChI=1S/C24H22N2O4/c1-2-15-13-19(14-21-22(15)20(27)9-12-29-21)30-23(17-7-10-26-11-8-17)16-3-5-18(6-4-16)24(25)28/h3-8,10-11,13-14,23H,2,9,12H2,1H3,(H2,25,28)	YEBQQSHEMOPOGI-UHFFFAOYSA-N	190911	(*R)-4-(((5-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 99a	HLA-DR4 protein			 42000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190911&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159140	316936179							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135815	CCc1cc(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2)cc2c1C(=O)CCO2	InChI=1S/C24H22N2O4/c1-2-15-13-19(14-21-22(15)20(27)9-12-29-21)30-23(17-7-10-26-11-8-17)16-3-5-18(6-4-16)24(25)28/h3-8,10-11,13-14,23H,2,9,12H2,1H3,(H2,25,28)	YEBQQSHEMOPOGI-UHFFFAOYSA-N	190912	(*S)-4-(((5-ethyl-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 99b	HLA-DR4 protein			>89000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190912&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159228	316936180							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135816	COc1c(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C23H20N2O5/c1-28-22-19(7-6-17-18(26)10-13-29-21(17)22)30-20(15-8-11-25-12-9-15)14-2-4-16(5-3-14)23(24)27/h2-9,11-12,20H,10,13H2,1H3,(H2,24,27)	CPKFWCBUPHZTFR-UHFFFAOYSA-N	190913	(*R)-4-(((8-methoxy-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 100a	HLA-DR4 protein			 6400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190913&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159269	316936181							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135817	COc1c(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OCCC2=O	InChI=1S/C23H20N2O5/c1-28-22-19(7-6-17-18(26)10-13-29-21(17)22)30-20(15-8-11-25-12-9-15)14-2-4-16(5-3-14)23(24)27/h2-9,11-12,20H,10,13H2,1H3,(H2,24,27)	CPKFWCBUPHZTFR-UHFFFAOYSA-N	190918	(*S)-4-(((8-methoxy-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 100b	HLA-DR4 protein			 9000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190918&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159119	316936182							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135818	N#Cc1cc(O[C@@H](c2ccncc2)c2ccc(C(N)=O)cc2)cc2c1C(=O)CCO2	InChI=1S/C23H17N3O4/c24-13-17-11-18(12-20-21(17)19(27)7-10-29-20)30-22(15-5-8-26-9-6-15)14-1-3-16(4-2-14)23(25)28/h1-6,8-9,11-12,22H,7,10H2,(H2,25,28)	MPANPUOKILDUNQ-UHFFFAOYSA-N	190919	(*R)-4-(((5-cyano-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 101a	HLA-DR4 protein			 960							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190919&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159299	316936183							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135819	N#Cc1cc(O[C@H](c2ccncc2)c2ccc(C(N)=O)cc2)cc2c1C(=O)CCO2	InChI=1S/C23H17N3O4/c24-13-17-11-18(12-20-21(17)19(27)7-10-29-20)30-22(15-5-8-26-9-6-15)14-1-3-16(4-2-14)23(25)28/h1-6,8-9,11-12,22H,7,10H2,(H2,25,28)	MPANPUOKILDUNQ-UHFFFAOYSA-N	190920	(*S)-4-(((5-cyano-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 101b	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190920&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159333	316936184							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135820	NC(=O)c1ccc([C@@H](Oc2ccc3c(c2Br)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H17BrN2O4/c23-19-18(6-5-16-17(26)9-12-28-21(16)19)29-20(14-7-10-25-11-8-14)13-1-3-15(4-2-13)22(24)27/h1-8,10-11,20H,9,12H2,(H2,24,27)	DKFWXAUZOREPGD-UHFFFAOYSA-N	190921	(*R)-4-(((8-bromo-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 102a	HLA-DR4 protein			 78000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190921&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159172	316936185							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135821	NC(=O)c1ccc([C@H](Oc2ccc3c(c2Br)OCCC3=O)c2ccncc2)cc1	InChI=1S/C22H17BrN2O4/c23-19-18(6-5-16-17(26)9-12-28-21(16)19)29-20(14-7-10-25-11-8-14)13-1-3-15(4-2-13)22(24)27/h1-8,10-11,20H,9,12H2,(H2,24,27)	DKFWXAUZOREPGD-UHFFFAOYSA-N	190922	(*S)-4-(((8-bromo-4-oxochroman-7-yl)oxy)(pyridin-4-yl)methyl)benzamide::US12516038, Example 102b	HLA-DR4 protein			>89000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190922&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159342	316936186							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135822	COc1ccc([C@@H](Oc2c(F)cc3c(c2C)OCCC3=O)c2ccncc2)cc1	InChI=1S/C23H20FNO4/c1-14-21-18(20(26)9-12-28-21)13-19(24)22(14)29-23(16-7-10-25-11-8-16)15-3-5-17(27-2)6-4-15/h3-8,10-11,13,23H,9,12H2,1-2H3	SGYGKQRXBMKCEW-UHFFFAOYSA-N	190923	(*R)-6-fluoro-7-((4-methoxyphenyl)(pyridin-4-yl)methoxy)-8-methylchroman-4-one::US12516038, Example 103a	HLA-DR4 protein			 2900							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190923&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159227	316936187							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135823	COc1ccc([C@H](Oc2c(F)cc3c(c2C)OCCC3=O)c2ccncc2)cc1	InChI=1S/C23H20FNO4/c1-14-21-18(20(26)9-12-28-21)13-19(24)22(14)29-23(16-7-10-25-11-8-16)15-3-5-17(27-2)6-4-15/h3-8,10-11,13,23H,9,12H2,1-2H3	SGYGKQRXBMKCEW-UHFFFAOYSA-N	190924	(*S)-6-fluoro-7-((4-methoxyphenyl)(pyridin-4-yl)methoxy)-8-methylchroman-4-one::US12516038, Example 103b	HLA-DR4 protein			 2800							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190924&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159163	316936188							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135824	Cc1c(O[C@@H](c2ccncc2)c2ccc(S(C)(=O)=O)cc2)c(F)cc2c1OCCC2=O	InChI=1S/C23H20FNO5S/c1-14-21-18(20(26)9-12-29-21)13-19(24)22(14)30-23(16-7-10-25-11-8-16)15-3-5-17(6-4-15)31(2,27)28/h3-8,10-11,13,23H,9,12H2,1-2H3	WPJDNRAFZVTBDF-UHFFFAOYSA-N	190925	(*R)-6-fluoro-8-methyl-7-((4-(methylsulfonyl)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 104a	HLA-DR4 protein			 290							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190925&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159345	316936189							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135825	Cc1c(O[C@H](c2ccncc2)c2ccc(S(C)(=O)=O)cc2)c(F)cc2c1OCCC2=O	InChI=1S/C23H20FNO5S/c1-14-21-18(20(26)9-12-29-21)13-19(24)22(14)30-23(16-7-10-25-11-8-16)15-3-5-17(6-4-15)31(2,27)28/h3-8,10-11,13,23H,9,12H2,1-2H3	WPJDNRAFZVTBDF-UHFFFAOYSA-N	190926	(*S)-6-fluoro-8-methyl-7-((4-(methylsulfonyl)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 104b	HLA-DR4 protein			 230							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190926&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159181	316936190							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135826	Cc1c(O[C@H](c2ccncc2)c2cccc(S(C)(=O)=O)c2)c(F)cc2c1OCCC2=O	InChI=1S/C23H20FNO5S/c1-14-21-18(20(26)8-11-29-21)13-19(24)22(14)30-23(15-6-9-25-10-7-15)16-4-3-5-17(12-16)31(2,27)28/h3-7,9-10,12-13,23H,8,11H2,1-2H3	QQZNJMIZMVCIME-UHFFFAOYSA-N	190927	(*R)-6-fluoro-8-methyl-7-((3-(methylsulfonyl)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 105a	HLA-DR4 protein			 200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190927&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159310	316936191							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135827	Cc1c(O[C@@H](c2ccncc2)c2cccc(S(C)(=O)=O)c2)c(F)cc2c1OCCC2=O	InChI=1S/C23H20FNO5S/c1-14-21-18(20(26)8-11-29-21)13-19(24)22(14)30-23(15-6-9-25-10-7-15)16-4-3-5-17(12-16)31(2,27)28/h3-7,9-10,12-13,23H,8,11H2,1-2H3	QQZNJMIZMVCIME-UHFFFAOYSA-N	190928	(*S)-6-fluoro-8-methyl-7-((3-(methylsulfonyl)phenyl)(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 105b	HLA-DR4 protein			 190							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190928&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159338	316936192							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135828	Cc1cc([C@H](Oc2ccc3c(c2C(C)C)OCCC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C27H28N2O4/c1-15(2)24-23(10-9-21-22(30)11-12-32-26(21)24)33-25(20-13-16(3)29-17(4)14-20)18-5-7-19(8-6-18)27(28)31/h5-10,13-15,25H,11-12H2,1-4H3,(H2,28,31)	IYVWPVFTFSXRBU-UHFFFAOYSA-N	190929	(*R)-4-((2,6-dimethylpyridin-4-yl)((8-isopropyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 106a	HLA-DR4 protein			 470							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190929&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159258	316936193							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135829	Cc1cc([C@@H](Oc2ccc3c(c2C(C)C)OCCC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C27H28N2O4/c1-15(2)24-23(10-9-21-22(30)11-12-32-26(21)24)33-25(20-13-16(3)29-17(4)14-20)18-5-7-19(8-6-18)27(28)31/h5-10,13-15,25H,11-12H2,1-4H3,(H2,28,31)	IYVWPVFTFSXRBU-UHFFFAOYSA-N	190930	(*S)-4-((2,6-dimethylpyridin-4-yl)((8-isopropyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 106b	HLA-DR4 protein			 740							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190930&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159298	316936194							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135830	CC(C)c1c(O[C@H](c2ccc(C(N)=O)cc2)c2cccc(C#N)c2)ccc2c1OCCC2=O	InChI=1S/C27H24N2O4/c1-16(2)24-23(11-10-21-22(30)12-13-32-26(21)24)33-25(20-5-3-4-17(14-20)15-28)18-6-8-19(9-7-18)27(29)31/h3-11,14,16,25H,12-13H2,1-2H3,(H2,29,31)	JJVFCIFGSUIQHU-UHFFFAOYSA-N	190931	(*R)-4-((3-cyanophenyl)((8-isopropyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 107a	HLA-DR4 protein			 940							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190931&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159363	316936195							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135831	CC(C)c1c(O[C@@H](c2ccc(C(N)=O)cc2)c2cccc(C#N)c2)ccc2c1OCCC2=O	InChI=1S/C27H24N2O4/c1-16(2)24-23(11-10-21-22(30)12-13-32-26(21)24)33-25(20-5-3-4-17(14-20)15-28)18-6-8-19(9-7-18)27(29)31/h3-11,14,16,25H,12-13H2,1-2H3,(H2,29,31)	JJVFCIFGSUIQHU-UHFFFAOYSA-N	190932	(*S)-4-((3-cyanophenyl)((8-isopropyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 107b	HLA-DR4 protein			 1100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190932&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118180375	316936196							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135832	CC(C)c1c(O[C@H](c2ccc(C(N)=O)cc2)c2ccc(C(=O)O)cc2)ccc2c1OCCC2=O	InChI=1S/C27H25NO6/c1-15(2)23-22(12-11-20-21(29)13-14-33-25(20)23)34-24(16-3-7-18(8-4-16)26(28)30)17-5-9-19(10-6-17)27(31)32/h3-12,15,24H,13-14H2,1-2H3,(H2,28,30)(H,31,32)	FPVQSFPTWZXAJK-UHFFFAOYSA-N	190933	(*R)-4-((4-carbamoylphenyl)((8-isopropyl-4-oxochroman-7-yl)oxy)methyl)benzoic acid::US12516038, Example 108a	HLA-DR4 protein			 860							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190933&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159169	316936197							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135833	CC(C)c1c(O[C@@H](c2ccc(C(N)=O)cc2)c2ccc(C(=O)O)cc2)ccc2c1OCCC2=O	InChI=1S/C27H25NO6/c1-15(2)23-22(12-11-20-21(29)13-14-33-25(20)23)34-24(16-3-7-18(8-4-16)26(28)30)17-5-9-19(10-6-17)27(31)32/h3-12,15,24H,13-14H2,1-2H3,(H2,28,30)(H,31,32)	FPVQSFPTWZXAJK-UHFFFAOYSA-N	190934	(*S)-4-((4-carbamoylphenyl)((8-isopropyl-4-oxochroman-7-yl)oxy)methyl)benzoic acid::US12516038, Example 108b	HLA-DR4 protein			 820							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190934&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159385	316936198							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135834	[H]C(=O)c1ccc([C@@H](Oc2cc3c(cc2F)C(=O)CCO3)c2cc(C)nc(C)c2)cc1	InChI=1S/C24H20FNO4/c1-14-9-18(10-15(2)26-14)24(17-5-3-16(13-27)4-6-17)30-23-12-22-19(11-20(23)25)21(28)7-8-29-22/h3-6,9-13,24H,7-8H2,1-2H3	DHQLPQBIOOUGGX-UHFFFAOYSA-N	190935	(*R)-4-((2,6-dimethylpyridin-4-yl)((6-fluoro-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 109a	HLA-DR4 protein			 210							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190935&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159393	316936199							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135835	[H]C(=O)c1ccc([C@H](Oc2cc3c(cc2F)C(=O)CCO3)c2cc(C)nc(C)c2)cc1	InChI=1S/C24H20FNO4/c1-14-9-18(10-15(2)26-14)24(17-5-3-16(13-27)4-6-17)30-23-12-22-19(11-20(23)25)21(28)7-8-29-22/h3-6,9-13,24H,7-8H2,1-2H3	DHQLPQBIOOUGGX-UHFFFAOYSA-N	190936	(*S)-4-((2,6-dimethylpyridin-4-yl)((6-fluoro-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 109b	HLA-DR4 protein			 230							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190936&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			91810771	316936200							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135836	Cc1cc([C@H](Oc2ccc3c(c2C#N)OCCC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C25H21N3O4/c1-14-11-18(12-15(2)28-14)23(16-3-5-17(6-4-16)25(27)30)32-22-8-7-19-21(29)9-10-31-24(19)20(22)13-26/h3-8,11-12,23H,9-10H2,1-2H3,(H2,27,30)	DLDJESDSUBMXEK-UHFFFAOYSA-N	190937	(*R)-4-(((8-cyano-4-oxochroman-7-yl)oxy)(2,6-dimethylpyridin-4-yl)methyl)benzamide::US12516038, Example 110a	HLA-DR4 protein			 550							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190937&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159362	316936201							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135837	Cc1cc([C@@H](Oc2ccc3c(c2C#N)OCCC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C25H21N3O4/c1-14-11-18(12-15(2)28-14)23(16-3-5-17(6-4-16)25(27)30)32-22-8-7-19-21(29)9-10-31-24(19)20(22)13-26/h3-8,11-12,23H,9-10H2,1-2H3,(H2,27,30)	DLDJESDSUBMXEK-UHFFFAOYSA-N	190938	(*S)-4-(((8-cyano-4-oxochroman-7-yl)oxy)(2,6-dimethylpyridin-4-yl)methyl)benzamide::US12516038, Example 110b	HLA-DR4 protein			 610							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190938&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159408	316936202							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135838	Cc1cc([C@H](Oc2ccc3c(c2C)OCCC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C25H24N2O4/c1-14-12-19(13-15(2)27-14)24(17-4-6-18(7-5-17)25(26)29)31-22-9-8-20-21(28)10-11-30-23(20)16(22)3/h4-9,12-13,24H,10-11H2,1-3H3,(H2,26,29)	JDIAKVRBISTFRT-UHFFFAOYSA-N	190939	(*R)-4-((2,6-dimethylpyridin-4-yl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 111a	HLA-DR4 protein			 490							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190939&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159182	316936203							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135839	Cc1cc([C@@H](Oc2ccc3c(c2C)OCCC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C25H24N2O4/c1-14-12-19(13-15(2)27-14)24(17-4-6-18(7-5-17)25(26)29)31-22-9-8-20-21(28)10-11-30-23(20)16(22)3/h4-9,12-13,24H,10-11H2,1-3H3,(H2,26,29)	JDIAKVRBISTFRT-UHFFFAOYSA-N	190940	(*S)-4-((2,6-dimethylpyridin-4-yl)((8-methyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 111b	HLA-DR4 protein			 560							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190940&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159253	316936204							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135840	Cc1cc([C@H](Oc2ccc3c(c2C)OC(C)(C)CC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C27H28N2O4/c1-15-12-20(13-16(2)29-15)25(18-6-8-19(9-7-18)26(28)31)32-23-11-10-21-22(30)14-27(4,5)33-24(21)17(23)3/h6-13,25H,14H2,1-5H3,(H2,28,31)	RBXYZWLPWOFBMA-UHFFFAOYSA-N	190941	(*R)-4-((2,6-dimethylpyridin-4-yl)((2,2,8-trimethyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 112a	HLA-DR4 protein			 760							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190941&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159325	316936205							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135841	Cc1cc([C@@H](Oc2ccc3c(c2C)OC(C)(C)CC3=O)c2ccc(C(N)=O)cc2)cc(C)n1	InChI=1S/C27H28N2O4/c1-15-12-20(13-16(2)29-15)25(18-6-8-19(9-7-18)26(28)31)32-23-11-10-21-22(30)14-27(4,5)33-24(21)17(23)3/h6-13,25H,14H2,1-5H3,(H2,28,31)	RBXYZWLPWOFBMA-UHFFFAOYSA-N	190942	(*S)-4-((2,6-dimethylpyridin-4-yl)((2,2,8-trimethyl-4-oxochroman-7-yl)oxy)methyl)benzamide::US12516038, Example 112b	HLA-DR4 protein			 600							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190942&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159355	316936206							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135842	Cc1c(OC(c2ccncc2)c2ccc(C(N)=O)cc2)ccc2c1OC(C)(C)CC2=O	InChI=1S/C25H24N2O4/c1-15-21(9-8-19-20(28)14-25(2,3)31-22(15)19)30-23(17-10-12-27-13-11-17)16-4-6-18(7-5-16)24(26)29/h4-13,23H,14H2,1-3H3,(H2,26,29)	GGMIMHKOMZSRNO-UHFFFAOYSA-N	190943	US12516038, Example 113	HLA-DR4 protein			 820							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190943&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159383	316936207							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135843	O=C1CCOc2cc(OC(c3ccccc3)c3ccncc3)ccc21	InChI=1S/C21H17NO3/c23-19-10-13-24-20-14-17(6-7-18(19)20)25-21(15-4-2-1-3-5-15)16-8-11-22-12-9-16/h1-9,11-12,14,21H,10,13H2	HRCJHFAAKVOPGJ-UHFFFAOYSA-N	190944	US12516038, Example 114	HLA-DR4 protein			 3400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190944&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159380	316936208							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135844	O=C1CCOc2cc(O[C@H](c3ccccc3)c3ccncc3)ccc21	InChI=1S/C21H17NO3/c23-19-10-13-24-20-14-17(6-7-18(19)20)25-21(15-4-2-1-3-5-15)16-8-11-22-12-9-16/h1-9,11-12,14,21H,10,13H2	HRCJHFAAKVOPGJ-UHFFFAOYSA-N	190945	(*R)-7-(phenyl(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 114a	HLA-DR4 protein			 1400							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190945&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159122	316936209							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135845	O=C1CCOc2cc(O[C@@H](c3ccccc3)c3ccncc3)ccc21	InChI=1S/C21H17NO3/c23-19-10-13-24-20-14-17(6-7-18(19)20)25-21(15-4-2-1-3-5-15)16-8-11-22-12-9-16/h1-9,11-12,14,21H,10,13H2	HRCJHFAAKVOPGJ-UHFFFAOYSA-N	190946	(*S)-7-(phenyl(pyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 114b	HLA-DR4 protein			 1300							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190946&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159341	316936210							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135846	O=C1CCOc2cc(OC(c3ccccc3)c3cccnc3)ccc21	InChI=1S/C21H17NO3/c23-19-10-12-24-20-13-17(8-9-18(19)20)25-21(15-5-2-1-3-6-15)16-7-4-11-22-14-16/h1-9,11,13-14,21H,10,12H2	UZBVLBZGYSDZQD-UHFFFAOYSA-N	190947	US12516038, Example 115	HLA-DR4 protein			 5000							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190947&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159289	316936211							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135847	Cc1cc(COc2ccc3c(c2C(C)C)OCCC3=O)cc(C)n1	InChI=1S/C20H23NO3/c1-12(2)19-18(6-5-16-17(22)7-8-23-20(16)19)24-11-15-9-13(3)21-14(4)10-15/h5-6,9-10,12H,7-8,11H2,1-4H3	MCNPVENZXXMETB-UHFFFAOYSA-N	190948	US12516038, Example 117	HLA-DR4 protein			 680							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190948&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159195	316936212							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135848	CC[C@@H]1CC(=O)c2ccc(OCc3ccnc(C)c3)cc2O1	InChI=1S/C18H19NO3/c1-3-14-9-17(20)16-5-4-15(10-18(16)22-14)21-11-13-6-7-19-12(2)8-13/h4-8,10,14H,3,9,11H2,1-2H3	DRVVWMXPFUYOEI-UHFFFAOYSA-N	190949	(*R)-2-ethyl-7-((2-methylpyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 118a	HLA-DR4 protein			 960							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190949&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159218	316936213							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135849	CC[C@H]1CC(=O)c2ccc(OCc3ccnc(C)c3)cc2O1	InChI=1S/C18H19NO3/c1-3-14-9-17(20)16-5-4-15(10-18(16)22-14)21-11-13-6-7-19-12(2)8-13/h4-8,10,14H,3,9,11H2,1-2H3	DRVVWMXPFUYOEI-UHFFFAOYSA-N	190950	(*S)-2-ethyl-7-((2-methylpyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 118b	HLA-DR4 protein			 990							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190950&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159173	316936214							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135850	CC[C@@H]1CC(=O)c2ccc(OCc3ccncc3OC)cc2O1	InChI=1S/C18H19NO4/c1-3-13-8-16(20)15-5-4-14(9-17(15)23-13)22-11-12-6-7-19-10-18(12)21-2/h4-7,9-10,13H,3,8,11H2,1-2H3	KSJHMJASBHGCCH-UHFFFAOYSA-N	190951	(*R)-2-ethyl-7-((3-methoxypyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 119a	HLA-DR4 protein			 540							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190951&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118180376	316936215							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135851	CC[C@H]1CC(=O)c2ccc(OCc3ccncc3OC)cc2O1	InChI=1S/C18H19NO4/c1-3-13-8-16(20)15-5-4-14(9-17(15)23-13)22-11-12-6-7-19-10-18(12)21-2/h4-7,9-10,13H,3,8,11H2,1-2H3	KSJHMJASBHGCCH-UHFFFAOYSA-N	190953	(*S)-2-ethyl-7-((3-methoxypyridin-4-yl)methoxy)chroman-4-one::US12516038, Example 119b	HLA-DR4 protein			 690							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190953&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159306	316936216							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135852	CCC1COc2cc(OCc3ccncc3)ccc2C1=O	InChI=1S/C17H17NO3/c1-2-13-11-21-16-9-14(3-4-15(16)17(13)19)20-10-12-5-7-18-8-6-12/h3-9,13H,2,10-11H2,1H3	XCHCERPOWLXAJA-UHFFFAOYSA-N	190954	US12516038, Example 120	HLA-DR4 protein			 1200							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190954&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159174	316936217							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135853	Cc1c(OC2CCc3cc(C(N)=O)ccc32)ccc2c1OCCC2=O	InChI=1S/C20H19NO4/c1-11-17(7-5-15-16(22)8-9-24-19(11)15)25-18-6-3-12-10-13(20(21)23)2-4-14(12)18/h2,4-5,7,10,18H,3,6,8-9H2,1H3,(H2,21,23)	FFMKOXZXTVKXEY-UHFFFAOYSA-N	190955	US12516038, Example 121	HLA-DR4 protein			 630							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190955&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159243	316936218							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135854	Cc1c(O[C@@H]2CCc3cc(C(N)=O)ccc32)ccc2c1OCCC2=O	InChI=1S/C20H19NO4/c1-11-17(7-5-15-16(22)8-9-24-19(11)15)25-18-6-3-12-10-13(20(21)23)2-4-14(12)18/h2,4-5,7,10,18H,3,6,8-9H2,1H3,(H2,21,23)	FFMKOXZXTVKXEY-UHFFFAOYSA-N	190956	(*R)-1-((8-methyl-4-oxochroman-7-yl)oxy)-2,3-dihydro-1H-indene-5-carboxamide::US12516038, Example 121a	HLA-DR4 protein			 930							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190956&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159251	316936219							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135855	Cc1c(O[C@H]2CCc3cc(C(N)=O)ccc32)ccc2c1OCCC2=O	InChI=1S/C20H19NO4/c1-11-17(7-5-15-16(22)8-9-24-19(11)15)25-18-6-3-12-10-13(20(21)23)2-4-14(12)18/h2,4-5,7,10,18H,3,6,8-9H2,1H3,(H2,21,23)	FFMKOXZXTVKXEY-UHFFFAOYSA-N	190957	(*S)-1-((8-methyl-4-oxochroman-7-yl)oxy)-2,3-dihydro-1H-indene-5-carboxamide::US12516038, Example 121b	HLA-DR4 protein			 830							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190957&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159372	316936220							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135856	Cc1c(OC2CCCc3cc(C#N)ccc32)ccc2c1OCCC2=O	InChI=1S/C21H19NO3/c1-13-19(8-7-17-18(23)9-10-24-21(13)17)25-20-4-2-3-15-11-14(12-22)5-6-16(15)20/h5-8,11,20H,2-4,9-10H2,1H3	GPJGEYNIRKFFHO-UHFFFAOYSA-N	190958	US12516038, Example 122	HLA-DR4 protein			 1100							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190958&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159272	316936221							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135857	Cc1c(O[C@@H]2CCCc3cc(C#N)ccc32)ccc2c1OCCC2=O	InChI=1S/C21H19NO3/c1-13-19(8-7-17-18(23)9-10-24-21(13)17)25-20-4-2-3-15-11-14(12-22)5-6-16(15)20/h5-8,11,20H,2-4,9-10H2,1H3	GPJGEYNIRKFFHO-UHFFFAOYSA-N	190959	(*R)-5-((8-methyl-4-oxochroman-7-yl)oxy)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile::US12516038, Example 122a	HLA-DR4 protein			 540							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190959&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159294	316936222							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135858	Cc1c(O[C@H]2CCCc3cc(C#N)ccc32)ccc2c1OCCC2=O	InChI=1S/C21H19NO3/c1-13-19(8-7-17-18(23)9-10-24-21(13)17)25-20-4-2-3-15-11-14(12-22)5-6-16(15)20/h5-8,11,20H,2-4,9-10H2,1H3	GPJGEYNIRKFFHO-UHFFFAOYSA-N	190960	(*S)-5-((8-methyl-4-oxochroman-7-yl)oxy)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile::US12516038, Example 122b	HLA-DR4 protein			 930							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190960&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159196	316936223							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135859	Cc1c(OC2CCCc3cc(C(N)=O)ccc32)ccc2c1OCCC2=O	InChI=1S/C21H21NO4/c1-12-18(8-7-16-17(23)9-10-25-20(12)16)26-19-4-2-3-13-11-14(21(22)24)5-6-15(13)19/h5-8,11,19H,2-4,9-10H2,1H3,(H2,22,24)	WLUGPYQWTUHXMK-UHFFFAOYSA-N	190961	US12516038, Example 123	HLA-DR4 protein			 520							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190961&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159150	316936224							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135860	Cc1c(O[C@@H]2CCCc3cc(C(N)=O)ccc32)ccc2c1OCCC2=O	InChI=1S/C21H21NO4/c1-12-18(8-7-16-17(23)9-10-25-20(12)16)26-19-4-2-3-13-11-14(21(22)24)5-6-15(13)19/h5-8,11,19H,2-4,9-10H2,1H3,(H2,22,24)	WLUGPYQWTUHXMK-UHFFFAOYSA-N	190962	(*R)-5-((8-methyl-4-oxochroman-7-yl)oxy)-5,6,7,8-tetrahydronaphthalene-2-carboxamide::US12516038, Example 123a	HLA-DR4 protein			 630							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190962&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159344	316936225							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135861	Cc1c(O[C@H]2CCCc3cc(C(N)=O)ccc32)ccc2c1OCCC2=O	InChI=1S/C21H21NO4/c1-12-18(8-7-16-17(23)9-10-25-20(12)16)26-19-4-2-3-13-11-14(21(22)24)5-6-15(13)19/h5-8,11,19H,2-4,9-10H2,1H3,(H2,22,24)	WLUGPYQWTUHXMK-UHFFFAOYSA-N	190963	(*S)-5-((8-methyl-4-oxochroman-7-yl)oxy)-5,6,7,8-tetrahydronaphthalene-2-carboxamide::US12516038, Example 123b	HLA-DR4 protein			 570							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190963&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159216	316936226							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135862	Cc1c(O[C@@H]2CCc3cnccc32)ccc2c1OCCC2=O	InChI=1S/C18H17NO3/c1-11-16(5-3-14-15(20)7-9-21-18(11)14)22-17-4-2-12-10-19-8-6-13(12)17/h3,5-6,8,10,17H,2,4,7,9H2,1H3	IEPCNQDGWYSYRF-UHFFFAOYSA-N	190964	(*R)-7-((6,7-dihydro-5H-cyclopenta[c]pyridin-5-yl)oxy)-8-methylchroman-4-one::US12516038, Example 124a	HLA-DR4 protein			 570							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190964&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159153	316936227							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
135863	Cc1c(O[C@H]2CCc3cnccc32)ccc2c1OCCC2=O	InChI=1S/C18H17NO3/c1-11-16(5-3-14-15(20)7-9-21-18(11)14)22-17-4-2-12-10-19-8-6-13(12)17/h3,5-6,8,10,17H,2,4,7,9H2,1H3	IEPCNQDGWYSYRF-UHFFFAOYSA-N	190965	(*S)-7-((6,7-dihydro-5H-cyclopenta[c]pyridin-5-yl)oxy)-8-methylchroman-4-one::US12516038, Example 124b	HLA-DR4 protein			 740							US Patent		10.7270/Q28057FQ			US12516038	Barbay, JK; Becart, S; Damm-Ganamet, KL; Hirst, GC; Kreutter, KD; Lebsack, AD	1/6/2026	5/18/2026	Janssen Pharmaceutica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2094&target=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190965&enzyme=HLA-DR4+protein&column=ki&startPg=0&Increment=50&submit=Search			118159276	316936228							1	RFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRALVDTYCRHNYGVGESFTVQRR	4X5X	HLA-DR4 protein	O77963_HUMAN	O77963