BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
136693	CC1CCN(c2nnn[nH]2)CC(NC(=O)C2(c3ccc(Cl)cc3)CC2)C1	InChI=1S/C18H23ClN6O/c1-12-6-9-25(17-21-23-24-22-17)11-15(10-12)20-16(26)18(7-8-18)13-2-4-14(19)5-3-13/h2-5,12,15H,6-11H2,1H3,(H,20,26)(H,21,22,23,24)	WVSNULXEMYBAJN-UHFFFAOYSA-N	226316	US20260007684, Compound Rac-1	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226316&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506995	336293463							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136694	C[C@@H]5CCN(c1nnn[nH]1)C[C@H](NC(=O)C4(c3ccc(C2CC2)cc3)CC4)C5	InChI=1S/C21H28N6O/c1-14-8-11-27(20-23-25-26-24-20)13-18(12-14)22-19(28)21(9-10-21)17-6-4-16(5-7-17)15-2-3-15/h4-7,14-15,18H,2-3,8-13H2,1H3,(H,22,28)(H,23,24,25,26)	UZWMWYFAOHDQCF-UHFFFAOYSA-N	226317	US20260007684, Compound 2A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226317&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506994	336293464							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136695	C[C@@H]5CCN(c1nnn[nH]1)C[C@@H](NC(=O)C4(c3ccc(C2CC2)cc3)CC4)C5	InChI=1S/C21H28N6O/c1-14-8-11-27(20-23-25-26-24-20)13-18(12-14)22-19(28)21(9-10-21)17-6-4-16(5-7-17)15-2-3-15/h4-7,14-15,18H,2-3,8-13H2,1H3,(H,22,28)(H,23,24,25,26)	UZWMWYFAOHDQCF-UHFFFAOYSA-N	226318	US20260007684, Compound 2B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226318&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497127	336293465							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136696	C[C@H]5CCN(c1nnn[nH]1)C[C@H](NC(=O)C4(c3ccc(C2CC2)cc3)CC4)C5	InChI=1S/C21H28N6O/c1-14-8-11-27(20-23-25-26-24-20)13-18(12-14)22-19(28)21(9-10-21)17-6-4-16(5-7-17)15-2-3-15/h4-7,14-15,18H,2-3,8-13H2,1H3,(H,22,28)(H,23,24,25,26)	UZWMWYFAOHDQCF-UHFFFAOYSA-N	226319	US20260007684, Compound 2C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226319&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506997	336293466							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136697	C[C@H]5CCN(c1nnn[nH]1)C[C@@H](NC(=O)C4(c3ccc(C2CC2)cc3)CC4)C5	InChI=1S/C21H28N6O/c1-14-8-11-27(20-23-25-26-24-20)13-18(12-14)22-19(28)21(9-10-21)17-6-4-16(5-7-17)15-2-3-15/h4-7,14-15,18H,2-3,8-13H2,1H3,(H,22,28)(H,23,24,25,26)	UZWMWYFAOHDQCF-UHFFFAOYSA-N	226320	US20260007684, Compound 2D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226320&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506996	336293467							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136698	C[C@@H]4CCN(c1nnn[nH]1)C[C@H](NC(=O)C3(c2ccc(OC(F)F)cc2F)CC3)C4	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(18-24-26-27-25-18)10-12(8-11)23-16(29)19(5-6-19)14-3-2-13(9-15(14)20)30-17(21)22/h2-3,9,11-12,17H,4-8,10H2,1H3,(H,23,29)(H,24,25,26,27)	SRCWJAXYPAZISY-UHFFFAOYSA-N	226321	US20260007684, Compound 3A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226321&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118507001	336293468							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136699	C[C@@H]4CCN(c1nnn[nH]1)C[C@@H](NC(=O)C3(c2ccc(OC(F)F)cc2F)CC3)C4	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(18-24-26-27-25-18)10-12(8-11)23-16(29)19(5-6-19)14-3-2-13(9-15(14)20)30-17(21)22/h2-3,9,11-12,17H,4-8,10H2,1H3,(H,23,29)(H,24,25,26,27)	SRCWJAXYPAZISY-UHFFFAOYSA-N	226322	US20260007684, Compound 3B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226322&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118508000	336293469							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136700	C[C@H]4CCN(c1nnn[nH]1)C[C@H](NC(=O)C3(c2ccc(OC(F)F)cc2F)CC3)C4	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(18-24-26-27-25-18)10-12(8-11)23-16(29)19(5-6-19)14-3-2-13(9-15(14)20)30-17(21)22/h2-3,9,11-12,17H,4-8,10H2,1H3,(H,23,29)(H,24,25,26,27)	SRCWJAXYPAZISY-UHFFFAOYSA-N	226323	US20260007684, Compound 3C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226323&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118507000	336293470							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136701	C[C@H]4CCN(c1nnn[nH]1)C[C@@H](NC(=O)C3(c2ccc(OC(F)F)cc2F)CC3)C4	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(18-24-26-27-25-18)10-12(8-11)23-16(29)19(5-6-19)14-3-2-13(9-15(14)20)30-17(21)22/h2-3,9,11-12,17H,4-8,10H2,1H3,(H,23,29)(H,24,25,26,27)	SRCWJAXYPAZISY-UHFFFAOYSA-N	226324	US20260007684, Compound 3D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226324&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506999	336293471							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136702	C[C@@H]4CCN(c1nnn[nH]1)C[C@H](NC(=O)C3(c2ccc(Cl)c(F)c2F)CC3)C4	InChI=1S/C18H21ClF2N6O/c1-10-4-7-27(17-23-25-26-24-17)9-11(8-10)22-16(28)18(5-6-18)12-2-3-13(19)15(21)14(12)20/h2-3,10-11H,4-9H2,1H3,(H,22,28)(H,23,24,25,26)	QKRBNXBDADWENF-UHFFFAOYSA-N	226325	US20260007684, Compound 4A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226325&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506998	336293472							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136703	C[C@@H]4CCN(c1nnn[nH]1)C[C@@H](NC(=O)C3(c2ccc(Cl)c(F)c2F)CC3)C4	InChI=1S/C18H21ClF2N6O/c1-10-4-7-27(17-23-25-26-24-17)9-11(8-10)22-16(28)18(5-6-18)12-2-3-13(19)15(21)14(12)20/h2-3,10-11H,4-9H2,1H3,(H,22,28)(H,23,24,25,26)	QKRBNXBDADWENF-UHFFFAOYSA-N	226326	US20260007684, Compound 4B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226326&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506652	336293473							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136704	C[C@H]4CCN(c1nnn[nH]1)C[C@H](NC(=O)C3(c2ccc(Cl)c(F)c2F)CC3)C4	InChI=1S/C18H21ClF2N6O/c1-10-4-7-27(17-23-25-26-24-17)9-11(8-10)22-16(28)18(5-6-18)12-2-3-13(19)15(21)14(12)20/h2-3,10-11H,4-9H2,1H3,(H,22,28)(H,23,24,25,26)	QKRBNXBDADWENF-UHFFFAOYSA-N	226327	US20260007684, Compound 4C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226327&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506654	336293474							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136705	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)c(F)c3F)CC2)C1	InChI=1S/C18H21ClF2N6O/c1-10-4-7-27(17-23-25-26-24-17)9-11(8-10)22-16(28)18(5-6-18)12-2-3-13(19)15(21)14(12)20/h2-3,10-11H,4-9H2,1H3,(H,22,28)(H,23,24,25,26)	QKRBNXBDADWENF-UHFFFAOYSA-N	226328	US20260007684, Compound 4D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226328&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506650	336293475							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136706	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)F)cc3)CC2)C1	InChI=1S/C19H24F2N6O/c1-12-6-9-27(18-23-25-26-24-18)11-15(10-12)22-17(28)19(7-8-19)14-4-2-13(3-5-14)16(20)21/h2-5,12,15-16H,6-11H2,1H3,(H,22,28)(H,23,24,25,26)	AXVAXKALBSVCJS-UHFFFAOYSA-N	226329	US20260007684, Compound 5A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226329&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506653	336293476							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136707	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)F)cc3)CC2)C1	InChI=1S/C19H24F2N6O/c1-12-6-9-27(18-23-25-26-24-18)11-15(10-12)22-17(28)19(7-8-19)14-4-2-13(3-5-14)16(20)21/h2-5,12,15-16H,6-11H2,1H3,(H,22,28)(H,23,24,25,26)	AXVAXKALBSVCJS-UHFFFAOYSA-N	226330	US20260007684, Compound 5B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226330&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506655	336293477							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136708	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)F)cc3)CC2)C1	InChI=1S/C19H24F2N6O/c1-12-6-9-27(18-23-25-26-24-18)11-15(10-12)22-17(28)19(7-8-19)14-4-2-13(3-5-14)16(20)21/h2-5,12,15-16H,6-11H2,1H3,(H,22,28)(H,23,24,25,26)	AXVAXKALBSVCJS-UHFFFAOYSA-N	226331	US20260007684, Compound 5C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226331&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506647	336293478							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136709	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)F)cc3)CC2)C1	InChI=1S/C19H24F2N6O/c1-12-6-9-27(18-23-25-26-24-18)11-15(10-12)22-17(28)19(7-8-19)14-4-2-13(3-5-14)16(20)21/h2-5,12,15-16H,6-11H2,1H3,(H,22,28)(H,23,24,25,26)	AXVAXKALBSVCJS-UHFFFAOYSA-N	226332	US20260007684, Compound 5D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226332&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506651	336293479							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136710	Cc1cc(C2(C(=O)N[C@@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)ccc1C(F)(F)F	InChI=1S/C20H25F3N6O/c1-12-5-8-29(18-25-27-28-26-18)11-15(9-12)24-17(30)19(6-7-19)14-3-4-16(13(2)10-14)20(21,22)23/h3-4,10,12,15H,5-9,11H2,1-2H3,(H,24,30)(H,25,26,27,28)	ACOYRDZJVLCFCD-UHFFFAOYSA-N	226333	US20260007684, Compound 6A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226333&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506648	336293480							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136711	Cc1cc(C2(C(=O)N[C@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)ccc1C(F)(F)F	InChI=1S/C20H25F3N6O/c1-12-5-8-29(18-25-27-28-26-18)11-15(9-12)24-17(30)19(6-7-19)14-3-4-16(13(2)10-14)20(21,22)23/h3-4,10,12,15H,5-9,11H2,1-2H3,(H,24,30)(H,25,26,27,28)	ACOYRDZJVLCFCD-UHFFFAOYSA-N	226334	US20260007684, Compound 6B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226334&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506649	336293481							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136712	Cc1cc(C2(C(=O)N[C@@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)ccc1C(F)(F)F	InChI=1S/C20H25F3N6O/c1-12-5-8-29(18-25-27-28-26-18)11-15(9-12)24-17(30)19(6-7-19)14-3-4-16(13(2)10-14)20(21,22)23/h3-4,10,12,15H,5-9,11H2,1-2H3,(H,24,30)(H,25,26,27,28)	ACOYRDZJVLCFCD-UHFFFAOYSA-N	226335	US20260007684, Compound 6C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226335&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497148	336293482							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136713	Cc1cc(C2(C(=O)N[C@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)ccc1Cl	InChI=1S/C19H25ClN6O/c1-12-5-8-26(18-22-24-25-23-18)11-15(9-12)21-17(27)19(6-7-19)14-3-4-16(20)13(2)10-14/h3-4,10,12,15H,5-9,11H2,1-2H3,(H,21,27)(H,22,23,24,25)	DTOPEWGRNSDTCX-UHFFFAOYSA-N	226336	US20260007684, Compound 6D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226336&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497098	336293483							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136714	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3cc(F)c(C(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H21F5N6O/c1-10-2-5-30(17-26-28-29-27-17)9-11(6-10)25-16(31)18(3-4-18)12-7-15(21)13(8-14(12)20)19(22,23)24/h7-8,10-11H,2-6,9H2,1H3,(H,25,31)(H,26,27,28,29)	HSUBIVJBLIOITD-UHFFFAOYSA-N	226337	US20260007684, Compound 7A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226337&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497133	336293484							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136715	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3cc(F)c(C(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H21F5N6O/c1-10-2-5-30(17-26-28-29-27-17)9-11(6-10)25-16(31)18(3-4-18)12-7-15(21)13(8-14(12)20)19(22,23)24/h7-8,10-11H,2-6,9H2,1H3,(H,25,31)(H,26,27,28,29)	HSUBIVJBLIOITD-UHFFFAOYSA-N	226338	US20260007684, Compound 7B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226338&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506935	336293485							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136716	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3cc(F)c(C(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H21F5N6O/c1-10-2-5-30(17-26-28-29-27-17)9-11(6-10)25-16(31)18(3-4-18)12-7-15(21)13(8-14(12)20)19(22,23)24/h7-8,10-11H,2-6,9H2,1H3,(H,25,31)(H,26,27,28,29)	HSUBIVJBLIOITD-UHFFFAOYSA-N	226339	US20260007684, Compound 7C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226339&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506932	336293486							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136717	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3cc(F)c(C(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H21F5N6O/c1-10-2-5-30(17-26-28-29-27-17)9-11(6-10)25-16(31)18(3-4-18)12-7-15(21)13(8-14(12)20)19(22,23)24/h7-8,10-11H,2-6,9H2,1H3,(H,25,31)(H,26,27,28,29)	HSUBIVJBLIOITD-UHFFFAOYSA-N	226340	US20260007684, Compound 7D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226340&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118508195	336293487							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136718	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C4CCC4)cc3)CC2)C1	InChI=1S/C22H30N6O/c1-15-9-12-28(21-24-26-27-25-21)14-19(13-15)23-20(29)22(10-11-22)18-7-5-17(6-8-18)16-3-2-4-16/h5-8,15-16,19H,2-4,9-14H2,1H3,(H,23,29)(H,24,25,26,27)	RNMBAAKVIOKFRK-UHFFFAOYSA-N	226341	US20260007684, Compound 8A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226341&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497107	336293488							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136719	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C4CCC4)cc3)CC2)C1	InChI=1S/C22H30N6O/c1-15-9-12-28(21-24-26-27-25-21)14-19(13-15)23-20(29)22(10-11-22)18-7-5-17(6-8-18)16-3-2-4-16/h5-8,15-16,19H,2-4,9-14H2,1H3,(H,23,29)(H,24,25,26,27)	RNMBAAKVIOKFRK-UHFFFAOYSA-N	226342	US20260007684, Compound 8B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226342&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497176	336293489							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136720	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C4CCC4)cc3)CC2)C1	InChI=1S/C22H30N6O/c1-15-9-12-28(21-24-26-27-25-21)14-19(13-15)23-20(29)22(10-11-22)18-7-5-17(6-8-18)16-3-2-4-16/h5-8,15-16,19H,2-4,9-14H2,1H3,(H,23,29)(H,24,25,26,27)	RNMBAAKVIOKFRK-UHFFFAOYSA-N	226343	US20260007684, Compound 8C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226343&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497172	336293490							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136721	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C4CCC4)cc3)CC2)C1	InChI=1S/C22H30N6O/c1-15-9-12-28(21-24-26-27-25-21)14-19(13-15)23-20(29)22(10-11-22)18-7-5-17(6-8-18)16-3-2-4-16/h5-8,15-16,19H,2-4,9-14H2,1H3,(H,23,29)(H,24,25,26,27)	RNMBAAKVIOKFRK-UHFFFAOYSA-N	226344	US20260007684, Compound 8D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226344&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505201	336293491							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136722	O=C(N[C@@H]1CCC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C19H23ClN6O/c20-13-6-4-12(5-7-13)19(10-11-19)17(27)21-15-3-1-2-14-8-9-16(15)26(14)18-22-24-25-23-18/h4-7,14-16H,1-3,8-11H2,(H,21,27)(H,22,23,24,25)	NVANYONWABXAGK-UHFFFAOYSA-N	226345	US20260007684, Compound 9A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226345&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505202	336293492							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136723	O=C(N[C@H]1CCC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C19H23ClN6O/c20-13-6-4-12(5-7-13)19(10-11-19)17(27)21-15-3-1-2-14-8-9-16(15)26(14)18-22-24-25-23-18/h4-7,14-16H,1-3,8-11H2,(H,21,27)(H,22,23,24,25)	NVANYONWABXAGK-UHFFFAOYSA-N	226346	US20260007684, Compound 9B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226346&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497168	336293493							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136724	O=C(N[C@@H]1CCC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C19H23ClN6O/c20-13-6-4-12(5-7-13)19(10-11-19)17(27)21-15-3-1-2-14-8-9-16(15)26(14)18-22-24-25-23-18/h4-7,14-16H,1-3,8-11H2,(H,21,27)(H,22,23,24,25)	NVANYONWABXAGK-UHFFFAOYSA-N	226347	US20260007684, Compound 9C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226347&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497130	336293494							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136725	O=C(N[C@H]1CCC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C19H23ClN6O/c20-13-6-4-12(5-7-13)19(10-11-19)17(27)21-15-3-1-2-14-8-9-16(15)26(14)18-22-24-25-23-18/h4-7,14-16H,1-3,8-11H2,(H,21,27)(H,22,23,24,25)	NVANYONWABXAGK-UHFFFAOYSA-N	226349	US20260007684, Compound 9D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226349&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497185	336293496							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136726	O=C(N[C@@H]1CCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C16H19ClN6O/c17-12-5-3-11(4-6-12)16(7-8-16)14(24)18-13-2-1-9-23(10-13)15-19-21-22-20-15/h3-6,13H,1-2,7-10H2,(H,18,24)(H,19,20,21,22)	JMWNOZOPDOKJMF-UHFFFAOYSA-N	226351	(R)-N-(1-(1H-tetrazol-5-yl)piperidin-3-yl)- 1-(4-chlorophenyl)cyclopropane-1- carboxamide::US20260007684, Compound 10A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226351&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506855	336293498							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136727	O=C(N[C@H]1CCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C16H19ClN6O/c17-12-5-3-11(4-6-12)16(7-8-16)14(24)18-13-2-1-9-23(10-13)15-19-21-22-20-15/h3-6,13H,1-2,7-10H2,(H,18,24)(H,19,20,21,22)	JMWNOZOPDOKJMF-UHFFFAOYSA-N	226352	(S)—N-(1-(1H-tetrazol-5-yl)piperidin-3-yl)-1-(4-chlorophenyl)cyclopropane-1-carboxamide ::US20260007684, Compound 10B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226352&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497074	336293499							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136728	C[C@@]1(NC(=O)C2(c3ccc(Cl)cc3)CC2)CCCN(c2nnn[nH]2)C1	InChI=1S/C17H21ClN6O/c1-16(7-2-10-24(11-16)15-20-22-23-21-15)19-14(25)17(8-9-17)12-3-5-13(18)6-4-12/h3-6H,2,7-11H2,1H3,(H,19,25)(H,20,21,22,23)	UWEBHRMRHGNIRH-UHFFFAOYSA-N	226353	US20260007684, Compound 11A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226353&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497139	336293500							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136729	C[C@]1(NC(=O)C2(c3ccc(Cl)cc3)CC2)CCCN(c2nnn[nH]2)C1	InChI=1S/C17H21ClN6O/c1-16(7-2-10-24(11-16)15-20-22-23-21-15)19-14(25)17(8-9-17)12-3-5-13(18)6-4-12/h3-6H,2,7-11H2,1H3,(H,19,25)(H,20,21,22,23)	UWEBHRMRHGNIRH-UHFFFAOYSA-N	226355	US20260007684, Compound 11B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226355&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118508253	336293502							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136730	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)C1	InChI=1S/C18H23ClN6O/c1-12-6-9-25(17-21-23-24-22-17)11-15(10-12)20-16(26)18(7-8-18)13-2-4-14(19)5-3-13/h2-5,12,15H,6-11H2,1H3,(H,20,26)(H,21,22,23,24)	WVSNULXEMYBAJN-UHFFFAOYSA-N	226356	US20260007684, Compound 12A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226356&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497081	336293503							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136731	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)C1	InChI=1S/C18H23ClN6O/c1-12-6-9-25(17-21-23-24-22-17)11-15(10-12)20-16(26)18(7-8-18)13-2-4-14(19)5-3-13/h2-5,12,15H,6-11H2,1H3,(H,20,26)(H,21,22,23,24)	WVSNULXEMYBAJN-UHFFFAOYSA-N	226357	US20260007684, Compound 12B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226357&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497105	336293504							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136732	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)C1	InChI=1S/C18H23ClN6O/c1-12-6-9-25(17-21-23-24-22-17)11-15(10-12)20-16(26)18(7-8-18)13-2-4-14(19)5-3-13/h2-5,12,15H,6-11H2,1H3,(H,20,26)(H,21,22,23,24)	WVSNULXEMYBAJN-UHFFFAOYSA-N	226359	US20260007684, Compound 12C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226359&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497187	336293506							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136733	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)C1	InChI=1S/C18H23ClN6O/c1-12-6-9-25(17-21-23-24-22-17)11-15(10-12)20-16(26)18(7-8-18)13-2-4-14(19)5-3-13/h2-5,12,15H,6-11H2,1H3,(H,20,26)(H,21,22,23,24)	WVSNULXEMYBAJN-UHFFFAOYSA-N	226360	US20260007684, Compound 12D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226360&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497009	336293507							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136734	O=C(N[C@H]1CC(C2CC2)CN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C19H23ClN6O/c20-15-5-3-14(4-6-15)19(7-8-19)17(27)21-16-9-13(12-1-2-12)10-26(11-16)18-22-24-25-23-18/h3-6,12-13,16H,1-2,7-11H2,(H,21,27)(H,22,23,24,25)	QCICBGKUUNIMKA-UHFFFAOYSA-N	226361	US20260007684, Compound Rac-13A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226361&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497101	336293508					C04080		1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136735	O=C(N[C@@H]1CC(C2CC2)CN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C19H23ClN6O/c20-15-5-3-14(4-6-15)19(7-8-19)17(27)21-16-9-13(12-1-2-12)10-26(11-16)18-22-24-25-23-18/h3-6,12-13,16H,1-2,7-11H2,(H,21,27)(H,22,23,24,25)	QCICBGKUUNIMKA-UHFFFAOYSA-N	226364	US20260007684, Compound Rac-13D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226364&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505209	336293511							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136736	O=C(N[C@@H]1C[C@@H](C2CC2)CN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C19H23ClN6O/c20-15-5-3-14(4-6-15)19(7-8-19)17(27)21-16-9-13(12-1-2-12)10-26(11-16)18-22-24-25-23-18/h3-6,12-13,16H,1-2,7-11H2,(H,21,27)(H,22,23,24,25)	QCICBGKUUNIMKA-UHFFFAOYSA-N	226365	US20260007684, Compound Rac-13B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226365&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505208	336293512							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136737	O=C(N[C@H]1C[C@H](C2CC2)CN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C19H23ClN6O/c20-15-5-3-14(4-6-15)19(7-8-19)17(27)21-16-9-13(12-1-2-12)10-26(11-16)18-22-24-25-23-18/h3-6,12-13,16H,1-2,7-11H2,(H,21,27)(H,22,23,24,25)	QCICBGKUUNIMKA-UHFFFAOYSA-N	226367	US20260007684, Compound Rac-13C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226367&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497103	336293514					C04080		1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136738	O=C(N[C@@H]1CCCCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C18H23ClN6O/c19-14-7-5-13(6-8-14)18(9-10-18)16(26)20-15-4-2-1-3-11-25(12-15)17-21-23-24-22-17/h5-8,15H,1-4,9-12H2,(H,20,26)(H,21,22,23,24)	OOHVSNWSKWQDNQ-UHFFFAOYSA-N	226368	US20260007684, Compound 14A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226368&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497159	336293515							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136739	O=C(N[C@H]1CCCCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C18H23ClN6O/c19-14-7-5-13(6-8-14)18(9-10-18)16(26)20-15-4-2-1-3-11-25(12-15)17-21-23-24-22-17/h5-8,15H,1-4,9-12H2,(H,20,26)(H,21,22,23,24)	OOHVSNWSKWQDNQ-UHFFFAOYSA-N	226369	US20260007684, Compound 14B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226369&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505212	336293516							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136740	O=C(N[C@@H]1CCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C16H19ClN6O2/c17-10-3-4-12(13(24)8-10)16(5-6-16)14(25)18-11-2-1-7-23(9-11)15-19-21-22-20-15/h3-4,8,11,24H,1-2,5-7,9H2,(H,18,25)(H,19,20,21,22)	DIXHDTLKBKVDTI-UHFFFAOYSA-N	226370	(R)-N-(1-(1H-tetrazol-5-yl)piperidin-3-yl)- 1-(4-chloro-2-hydroxyphenyl)cyclopropane- 1-carboxamide::US20260007684, Compound 15A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226370&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505210	336293517							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136741	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H21F3N6O2/c1-10-6-12(9-27(8-10)16-23-25-26-24-16)22-15(29)17(4-5-17)13-3-2-11(7-14(13)28)18(19,20)21/h2-3,7,10,12,28H,4-6,8-9H2,1H3,(H,22,29)(H,23,24,25,26)	RMVCTKCJUZBWOV-UHFFFAOYSA-N	226371	1-(2-hydroxy-4-(trifluoromethyl)phenyl)-N- ((3R,5S)-5-methyl-1-(1H-tetrazol-5- yl)piperidin-3-yl)cyclopropane-1- carboxamide::US20260007684, Compound 16A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226371&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505211	336293518							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136742	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H21F3N6O3/c1-10-6-11(9-27(8-10)16-23-25-26-24-16)22-15(29)17(4-5-17)13-3-2-12(7-14(13)28)30-18(19,20)21/h2-3,7,10-11,28H,4-6,8-9H2,1H3,(H,22,29)(H,23,24,25,26)	UOPIQGJQXMPOPE-UHFFFAOYSA-N	226372	1-(2-hydroxy-4-(trifluoromethoxy)phenyl)- N-((3R,5S)-5-methyl-1-(1H-tetrazol-5- yl)piperidin-3-yl)cyclopropane-1- carboxamide::US20260007684, Compound 17A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226372&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505213	336293519							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136743	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)c(F)c3O)CC2)C1	InChI=1S/C18H22ClFN6O2/c1-10-4-7-26(17-22-24-25-23-17)9-11(8-10)21-16(28)18(5-6-18)12-2-3-13(19)14(20)15(12)27/h2-3,10-11,27H,4-9H2,1H3,(H,21,28)(H,22,23,24,25)	TUKFVIXXBRJHSB-UHFFFAOYSA-N	226373	US20260007684, Compound 18A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226373&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506965	336293520							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136744	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)c(F)c3O)CC2)C1	InChI=1S/C18H22ClFN6O2/c1-10-4-7-26(17-22-24-25-23-17)9-11(8-10)21-16(28)18(5-6-18)12-2-3-13(19)14(20)15(12)27/h2-3,10-11,27H,4-9H2,1H3,(H,21,28)(H,22,23,24,25)	TUKFVIXXBRJHSB-UHFFFAOYSA-N	226374	US20260007684, Compound 18B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226374&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505215	336293521							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136745	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)c(F)c3O)CC2)C1	InChI=1S/C18H22ClFN6O2/c1-10-4-7-26(17-22-24-25-23-17)9-11(8-10)21-16(28)18(5-6-18)12-2-3-13(19)14(20)15(12)27/h2-3,10-11,27H,4-9H2,1H3,(H,21,28)(H,22,23,24,25)	TUKFVIXXBRJHSB-UHFFFAOYSA-N	226376	US20260007684, Compound 18C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226376&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497030	336293523							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136746	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)c(F)c3O)CC2)C1	InChI=1S/C18H22ClFN6O2/c1-10-4-7-26(17-22-24-25-23-17)9-11(8-10)21-16(28)18(5-6-18)12-2-3-13(19)14(20)15(12)27/h2-3,10-11,27H,4-9H2,1H3,(H,21,28)(H,22,23,24,25)	TUKFVIXXBRJHSB-UHFFFAOYSA-N	226378	US20260007684, Compound 18D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226378&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497068	336293525							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136747	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H22F2N6O3/c1-10-6-11(9-26(8-10)17-22-24-25-23-17)21-15(28)18(4-5-18)13-3-2-12(7-14(13)27)29-16(19)20/h2-3,7,10-11,16,27H,4-6,8-9H2,1H3,(H,21,28)(H,22,23,24,25)	VSNWLJVYSGGODQ-UHFFFAOYSA-N	226381	1-(4-(difluoromethoxy)-2-hydroxyphenyl)-N-((3R,5S)-5-methyl-1-(1H-tetrazol-5-yl)piperidin-3-yl)cyclopropane-1-carboxamide ::US20260007684, Compound 19A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226381&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505216	336293528							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136748	Cc1ccc(C2(C(=O)N[C@@H]3C[C@H](C)CN(c4nnn[nH]4)C3)CC2)c(O)c1	InChI=1S/C18H24N6O2/c1-11-3-4-14(15(25)8-11)18(5-6-18)16(26)19-13-7-12(2)9-24(10-13)17-20-22-23-21-17/h3-4,8,12-13,25H,5-7,9-10H2,1-2H3,(H,19,26)(H,20,21,22,23)	MCJLFLIWISDUAJ-UHFFFAOYSA-N	226382	1-(2-hydroxy-4-methylphenyl)-N-((3R,5S)-5-methyl-1-(1H-tetrazol-5-yl)piperidin-3-yl)cyclopropane-1-carboxamide ::US20260007684, Compound 20A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226382&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505218	336293529							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136749	Cc1c(Cl)ccc(C2(C(=O)N[C@@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c1O	InChI=1S/C19H25ClN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-3-4-15(20)12(2)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	AEMLUGSSSFVAPA-UHFFFAOYSA-N	226384	US20260007684, Compound 21A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226384&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505220	336293531							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136750	Cc1c(Cl)ccc(C2(C(=O)N[C@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c1O	InChI=1S/C19H25ClN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-3-4-15(20)12(2)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	AEMLUGSSSFVAPA-UHFFFAOYSA-N	226385	US20260007684, Compound 21B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226385&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505221	336293532							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136751	Cc1c(Cl)ccc(C2(C(=O)N[C@@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c1O	InChI=1S/C19H25ClN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-3-4-15(20)12(2)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	AEMLUGSSSFVAPA-UHFFFAOYSA-N	226386	US20260007684, Compound 21C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226386&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505222	336293533							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136752	Cc1c(Cl)ccc(C2(C(=O)N[C@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c1O	InChI=1S/C19H25ClN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-3-4-15(20)12(2)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	AEMLUGSSSFVAPA-UHFFFAOYSA-N	226390	US20260007684, Compound 21D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226390&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497029	336293537							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136753	Cc1ccc(C2(C(=O)N[C@@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1F	InChI=1S/C19H25FN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-4-3-12(2)15(20)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	WIDBXQYOPZWUPL-UHFFFAOYSA-N	226391	US20260007684, Compound 22A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226391&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497170	336293538							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136754	Cc1ccc(C2(C(=O)N[C@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1F	InChI=1S/C19H25FN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-4-3-12(2)15(20)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	WIDBXQYOPZWUPL-UHFFFAOYSA-N	226392	US20260007684, Compound 22B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226392&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497136	336293539							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136755	Cc1ccc(C2(C(=O)N[C@@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1F	InChI=1S/C19H25FN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-4-3-12(2)15(20)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	WIDBXQYOPZWUPL-UHFFFAOYSA-N	226393	US20260007684, Compound 22C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226393&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497047	336293540					C04080		1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136756	Cc1ccc(C2(C(=O)N[C@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1F	InChI=1S/C19H25FN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-4-3-12(2)15(20)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	WIDBXQYOPZWUPL-UHFFFAOYSA-N	226394	US20260007684, Compound 22D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226394&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497144	336293541							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136757	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C4CC4)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C20H26N6O2/c1-12-8-15(11-26(10-12)19-22-24-25-23-19)21-18(28)20(6-7-20)16-5-4-14(9-17(16)27)13-2-3-13/h4-5,9,12-13,15,27H,2-3,6-8,10-11H2,1H3,(H,21,28)(H,22,23,24,25)	QUPLJSNMYZIBGB-UHFFFAOYSA-N	226412	US20260007684, Compound 23A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226412&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497109	336293542							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136758	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)nc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C17H20F3N7O2/c1-9-6-10(8-27(7-9)15-23-25-26-24-15)21-14(29)16(4-5-16)11-2-3-12(17(18,19)20)22-13(11)28/h2-3,9-10H,4-8H2,1H3,(H,21,29)(H,22,28)(H,23,24,25,26)	DCPOWYPPNGZMTO-UHFFFAOYSA-N	226441	US20260007684, Compound 24A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226441&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505229	336293543							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136759	C[C@H]1C[C@@H](NC(=O)C2(c3ncc(C(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C17H20F3N7O2/c1-9-4-11(8-27(7-9)15-23-25-26-24-15)22-14(29)16(2-3-16)13-12(28)5-10(6-21-13)17(18,19)20/h5-6,9,11,28H,2-4,7-8H2,1H3,(H,22,29)(H,23,24,25,26)	KSPBQJWMMNPGCQ-UHFFFAOYSA-N	226442	US20260007684, Compound 25A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226442&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497046	336293544					C04080		1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136760	C[C@H]1C[C@@H](NC(=O)C2(c3cnc(C(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C17H20F3N7O2/c1-9-4-10(8-27(7-9)15-23-25-26-24-15)22-14(29)16(2-3-16)11-6-21-13(5-12(11)28)17(18,19)20/h5-6,9-10H,2-4,7-8H2,1H3,(H,21,28)(H,22,29)(H,23,24,25,26)	UULOIQJAMYPTLK-UHFFFAOYSA-N	226443	US20260007684, Compound 26A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226443&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497020	336293545							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136761	CC(C)c1ccc(C2(C(=O)N[C@@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1	InChI=1S/C21H30N6O2/c1-13(2)15-4-5-17(18(28)11-15)21(7-8-21)19(29)22-16-10-14(3)6-9-27(12-16)20-23-25-26-24-20/h4-5,11,13-14,16,28H,6-10,12H2,1-3H3,(H,22,29)(H,23,24,25,26)	PFBMFQKXESODRL-UHFFFAOYSA-N	226444	US20260007684, Compound 27A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226444&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497057	336293546							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136762	CC(C)c1ccc(C2(C(=O)N[C@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1	InChI=1S/C21H30N6O2/c1-13(2)15-4-5-17(18(28)11-15)21(7-8-21)19(29)22-16-10-14(3)6-9-27(12-16)20-23-25-26-24-20/h4-5,11,13-14,16,28H,6-10,12H2,1-3H3,(H,22,29)(H,23,24,25,26)	PFBMFQKXESODRL-UHFFFAOYSA-N	226445	US20260007684, Compound 27B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226445&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962605	336293547							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136763	CC(C)c1ccc(C2(C(=O)N[C@@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1	InChI=1S/C21H30N6O2/c1-13(2)15-4-5-17(18(28)11-15)21(7-8-21)19(29)22-16-10-14(3)6-9-27(12-16)20-23-25-26-24-20/h4-5,11,13-14,16,28H,6-10,12H2,1-3H3,(H,22,29)(H,23,24,25,26)	PFBMFQKXESODRL-UHFFFAOYSA-N	226446	US20260007684, Compound 27C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226446&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962606	336293548							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136764	CC(C)c1ccc(C2(C(=O)N[C@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1	InChI=1S/C21H30N6O2/c1-13(2)15-4-5-17(18(28)11-15)21(7-8-21)19(29)22-16-10-14(3)6-9-27(12-16)20-23-25-26-24-20/h4-5,11,13-14,16,28H,6-10,12H2,1-3H3,(H,22,29)(H,23,24,25,26)	PFBMFQKXESODRL-UHFFFAOYSA-N	226448	US20260007684, Compound 27D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226448&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962608	336293550							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136765	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)c(F)c3O)CC2)C1	InChI=1S/C19H22F4N6O3/c1-10-4-7-29(17-25-27-28-26-17)9-11(8-10)24-16(31)18(5-6-18)12-2-3-13(14(20)15(12)30)32-19(21,22)23/h2-3,10-11,30H,4-9H2,1H3,(H,24,31)(H,25,26,27,28)	JTFHRPZYTYQFAJ-UHFFFAOYSA-N	226449	US20260007684, Compound 28A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226449&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962609	336293551							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136766	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)c(F)c3O)CC2)C1	InChI=1S/C19H22F4N6O3/c1-10-4-7-29(17-25-27-28-26-17)9-11(8-10)24-16(31)18(5-6-18)12-2-3-13(14(20)15(12)30)32-19(21,22)23/h2-3,10-11,30H,4-9H2,1H3,(H,24,31)(H,25,26,27,28)	JTFHRPZYTYQFAJ-UHFFFAOYSA-N	226450	US20260007684, Compound 28B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226450&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962610	336293552							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136767	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)c(F)c3O)CC2)C1	InChI=1S/C19H22F4N6O3/c1-10-4-7-29(17-25-27-28-26-17)9-11(8-10)24-16(31)18(5-6-18)12-2-3-13(14(20)15(12)30)32-19(21,22)23/h2-3,10-11,30H,4-9H2,1H3,(H,24,31)(H,25,26,27,28)	JTFHRPZYTYQFAJ-UHFFFAOYSA-N	226451	US20260007684, Compound 28C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226451&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962611	336293553							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136768	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)c(F)c3O)CC2)C1	InChI=1S/C19H22F4N6O3/c1-10-4-7-29(17-25-27-28-26-17)9-11(8-10)24-16(31)18(5-6-18)12-2-3-13(14(20)15(12)30)32-19(21,22)23/h2-3,10-11,30H,4-9H2,1H3,(H,24,31)(H,25,26,27,28)	JTFHRPZYTYQFAJ-UHFFFAOYSA-N	226452	US20260007684, Compound 28D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226452&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962612	336293554							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136769	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3cc(F)c(Cl)cc3O)CC2)C1	InChI=1S/C18H22ClFN6O2/c1-10-2-5-26(17-22-24-25-23-17)9-11(6-10)21-16(28)18(3-4-18)12-7-14(20)13(19)8-15(12)27/h7-8,10-11,27H,2-6,9H2,1H3,(H,21,28)(H,22,23,24,25)	AUOIJCKJINHDND-UHFFFAOYSA-N	226453	US20260007684, Compound 29A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226453&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962613	336293555							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136770	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3cc(F)c(Cl)cc3O)CC2)C1	InChI=1S/C18H22ClFN6O2/c1-10-2-5-26(17-22-24-25-23-17)9-11(6-10)21-16(28)18(3-4-18)12-7-14(20)13(19)8-15(12)27/h7-8,10-11,27H,2-6,9H2,1H3,(H,21,28)(H,22,23,24,25)	AUOIJCKJINHDND-UHFFFAOYSA-N	226454	US20260007684, Compound 29D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226454&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962614	336293556							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136771	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)F)cc3O)CC2)C1	InChI=1S/C19H24F2N6O2/c1-11-4-7-27(18-23-25-26-24-18)10-13(8-11)22-17(29)19(5-6-19)14-3-2-12(16(20)21)9-15(14)28/h2-3,9,11,13,16,28H,4-8,10H2,1H3,(H,22,29)(H,23,24,25,26)	BOXJEQUJBYTCDR-UHFFFAOYSA-N	226455	US20260007684, Compound 30A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226455&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962615	336293557							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136772	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)F)cc3O)CC2)C1	InChI=1S/C19H24F2N6O2/c1-11-4-7-27(18-23-25-26-24-18)10-13(8-11)22-17(29)19(5-6-19)14-3-2-12(16(20)21)9-15(14)28/h2-3,9,11,13,16,28H,4-8,10H2,1H3,(H,22,29)(H,23,24,25,26)	BOXJEQUJBYTCDR-UHFFFAOYSA-N	226456	US20260007684, Compound 30B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226456&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962616	336293558							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136773	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)F)cc3O)CC2)C1	InChI=1S/C19H24F2N6O2/c1-11-4-7-27(18-23-25-26-24-18)10-13(8-11)22-17(29)19(5-6-19)14-3-2-12(16(20)21)9-15(14)28/h2-3,9,11,13,16,28H,4-8,10H2,1H3,(H,22,29)(H,23,24,25,26)	BOXJEQUJBYTCDR-UHFFFAOYSA-N	226457	US20260007684, Compound 30C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226457&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962617	336293559							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136774	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)F)cc3O)CC2)C1	InChI=1S/C19H24F2N6O2/c1-11-4-7-27(18-23-25-26-24-18)10-13(8-11)22-17(29)19(5-6-19)14-3-2-12(16(20)21)9-15(14)28/h2-3,9,11,13,16,28H,4-8,10H2,1H3,(H,22,29)(H,23,24,25,26)	BOXJEQUJBYTCDR-UHFFFAOYSA-N	226458	US20260007684, Compound 30D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226458&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962618	336293560							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136775	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)c(F)c3O)CC2)C1	InChI=1S/C19H22F4N6O2/c1-10-4-7-29(17-25-27-28-26-17)9-11(8-10)24-16(31)18(5-6-18)13-3-2-12(19(21,22)23)14(20)15(13)30/h2-3,10-11,30H,4-9H2,1H3,(H,24,31)(H,25,26,27,28)	VDZUUAOMMGWVGP-UHFFFAOYSA-N	226459	US20260007684, Compound 31A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226459&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962619	336293561							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136776	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)c(F)c3O)CC2)C1	InChI=1S/C19H22F4N6O2/c1-10-4-7-29(17-25-27-28-26-17)9-11(8-10)24-16(31)18(5-6-18)13-3-2-12(19(21,22)23)14(20)15(13)30/h2-3,10-11,30H,4-9H2,1H3,(H,24,31)(H,25,26,27,28)	VDZUUAOMMGWVGP-UHFFFAOYSA-N	226460	US20260007684, Compound 31B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226460&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962620	336293562							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136777	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)c(F)c3O)CC2)C1	InChI=1S/C19H22F4N6O2/c1-10-4-7-29(17-25-27-28-26-17)9-11(8-10)24-16(31)18(5-6-18)13-3-2-12(19(21,22)23)14(20)15(13)30/h2-3,10-11,30H,4-9H2,1H3,(H,24,31)(H,25,26,27,28)	VDZUUAOMMGWVGP-UHFFFAOYSA-N	226461	US20260007684, Compound 31C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226461&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			121297535	336293563							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136778	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)c(F)c3O)CC2)C1	InChI=1S/C19H22F4N6O2/c1-10-4-7-29(17-25-27-28-26-17)9-11(8-10)24-16(31)18(5-6-18)13-3-2-12(19(21,22)23)14(20)15(13)30/h2-3,10-11,30H,4-9H2,1H3,(H,24,31)(H,25,26,27,28)	VDZUUAOMMGWVGP-UHFFFAOYSA-N	226462	US20260007684, Compound 31D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226462&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962621	336293564							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136779	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C4CC4)c(F)c3O)CC2)C1	InChI=1S/C21H27FN6O2/c1-12-6-9-28(20-24-26-27-25-20)11-14(10-12)23-19(30)21(7-8-21)16-5-4-15(13-2-3-13)17(22)18(16)29/h4-5,12-14,29H,2-3,6-11H2,1H3,(H,23,30)(H,24,25,26,27)	GARAZYMCEOEJNV-UHFFFAOYSA-N	226463	US20260007684, Compound 32A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226463&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962622	336293565							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136780	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C4CC4)c(F)c3O)CC2)C1	InChI=1S/C21H27FN6O2/c1-12-6-9-28(20-24-26-27-25-20)11-14(10-12)23-19(30)21(7-8-21)16-5-4-15(13-2-3-13)17(22)18(16)29/h4-5,12-14,29H,2-3,6-11H2,1H3,(H,23,30)(H,24,25,26,27)	GARAZYMCEOEJNV-UHFFFAOYSA-N	226464	US20260007684, Compound 32B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226464&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962623	336293566							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136781	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C4CC4)c(F)c3O)CC2)C1	InChI=1S/C21H27FN6O2/c1-12-6-9-28(20-24-26-27-25-20)11-14(10-12)23-19(30)21(7-8-21)16-5-4-15(13-2-3-13)17(22)18(16)29/h4-5,12-14,29H,2-3,6-11H2,1H3,(H,23,30)(H,24,25,26,27)	GARAZYMCEOEJNV-UHFFFAOYSA-N	226465	US20260007684, Compound 32C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226465&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962624	336293567							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136782	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C4CC4)c(F)c3O)CC2)C1	InChI=1S/C21H27FN6O2/c1-12-6-9-28(20-24-26-27-25-20)11-14(10-12)23-19(30)21(7-8-21)16-5-4-15(13-2-3-13)17(22)18(16)29/h4-5,12-14,29H,2-3,6-11H2,1H3,(H,23,30)(H,24,25,26,27)	GARAZYMCEOEJNV-UHFFFAOYSA-N	226466	US20260007684, Compound 32D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226466&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962625	336293568							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136783	Cc1cc(Cl)cc(O)c1C1(C(=O)N[C@@H]2C[C@H](C)CN(c3nnn[nH]3)C2)CC1	InChI=1S/C18H23ClN6O2/c1-10-5-13(9-25(8-10)17-21-23-24-22-17)20-16(27)18(3-4-18)15-11(2)6-12(19)7-14(15)26/h6-7,10,13,26H,3-5,8-9H2,1-2H3,(H,20,27)(H,21,22,23,24)	PLWKRSLSAGNZGH-UHFFFAOYSA-N	226467	US20260007684, Compound 33A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226467&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962626	336293569							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136784	O=C(N[C@H]1CC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(C(F)(F)F)cc2O)CC1	InChI=1S/C19H21F3N6O2/c20-19(21,22)10-1-4-12(15(29)9-10)18(7-8-18)16(30)23-13-5-2-11-3-6-14(13)28(11)17-24-26-27-25-17/h1,4,9,11,13-14,29H,2-3,5-8H2,(H,23,30)(H,24,25,26,27)	UKUYNWRJDQLQIR-UHFFFAOYSA-N	226468	US20260007684, Compound 34B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226468&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962627	336293570							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136785	O=C(N[C@@H]1CC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(C(F)(F)F)cc2O)CC1	InChI=1S/C19H21F3N6O2/c20-19(21,22)10-1-4-12(15(29)9-10)18(7-8-18)16(30)23-13-5-2-11-3-6-14(13)28(11)17-24-26-27-25-17/h1,4,9,11,13-14,29H,2-3,5-8H2,(H,23,30)(H,24,25,26,27)	UKUYNWRJDQLQIR-UHFFFAOYSA-N	226469	US20260007684, Compound 34C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226469&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962628	336293571							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136786	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O2/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	YMMXYIXOCJMVQF-UHFFFAOYSA-N	226470	US20260007684, Compound 35A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226470&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962629	336293572							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136787	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O2/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	YMMXYIXOCJMVQF-UHFFFAOYSA-N	226471	US20260007684, Compound 35B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226471&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962630	336293573							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136788	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O2/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	YMMXYIXOCJMVQF-UHFFFAOYSA-N	226472	US20260007684, Compound 35C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226472&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962631	336293574							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136789	C[C@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O2/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	YMMXYIXOCJMVQF-UHFFFAOYSA-N	226473	US20260007684, Compound 35D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226473&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962632	336293575							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136790	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O2/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	YMMXYIXOCJMVQF-UHFFFAOYSA-N	226474	US20260007684, Compound 35E	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226474&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962633	336293576							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136791	C[C@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O2/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	YMMXYIXOCJMVQF-UHFFFAOYSA-N	226475	US20260007684, Compound 35F	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226475&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			121297534	336293577							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136792	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O2/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	YMMXYIXOCJMVQF-UHFFFAOYSA-N	226476	US20260007684, Compound 35G	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226476&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962634	336293578							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136793	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O2/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	YMMXYIXOCJMVQF-UHFFFAOYSA-N	226477	US20260007684, Compound 35H	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226477&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962635	336293579							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136794	C[C@H]1CC[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O/c1-12-2-7-15(11-25(10-12)17-21-23-24-22-17)20-16(26)18(8-9-18)13-3-5-14(19)6-4-13/h3-6,12,15H,2,7-11H2,1H3,(H,20,26)(H,21,22,23,24)	XOQWQTRYQKASNF-UHFFFAOYSA-N	226478	US20260007684, Compound 36A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226478&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962636	336293580							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136795	C[C@H]1CC[C@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O/c1-12-2-7-15(11-25(10-12)17-21-23-24-22-17)20-16(26)18(8-9-18)13-3-5-14(19)6-4-13/h3-6,12,15H,2,7-11H2,1H3,(H,20,26)(H,21,22,23,24)	XOQWQTRYQKASNF-UHFFFAOYSA-N	226479	US20260007684, Compound 36B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226479&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962637	336293581							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136796	C[C@@H]1CC[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O/c1-12-2-7-15(11-25(10-12)17-21-23-24-22-17)20-16(26)18(8-9-18)13-3-5-14(19)6-4-13/h3-6,12,15H,2,7-11H2,1H3,(H,20,26)(H,21,22,23,24)	XOQWQTRYQKASNF-UHFFFAOYSA-N	226480	US20260007684, Compound 36C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226480&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118497055	336293582							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136797	C[C@@H]1CC[C@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O/c1-12-2-7-15(11-25(10-12)17-21-23-24-22-17)20-16(26)18(8-9-18)13-3-5-14(19)6-4-13/h3-6,12,15H,2,7-11H2,1H3,(H,20,26)(H,21,22,23,24)	XOQWQTRYQKASNF-UHFFFAOYSA-N	226481	US20260007684, Compound 36D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226481&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962638	336293583							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136798	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(C4CC4(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C22H26F2N6O/c1-12-10-16(18-7-6-17(12)30(18)20-26-28-29-27-20)25-19(31)21(8-9-21)14-4-2-13(3-5-14)15-11-22(15,23)24/h2-5,12,15-18H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	BXVPQQHMZMLJFL-UHFFFAOYSA-N	226482	US20260007684, Compound 37A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226482&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962639	336293584							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136799	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(C4CC4(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C22H26F2N6O/c1-12-10-16(18-7-6-17(12)30(18)20-26-28-29-27-20)25-19(31)21(8-9-21)14-4-2-13(3-5-14)15-11-22(15,23)24/h2-5,12,15-18H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	BXVPQQHMZMLJFL-UHFFFAOYSA-N	226483	US20260007684, Compound 37B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226483&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962640	336293585							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136800	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C4CC4(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C22H26F2N6O/c1-12-10-16(18-7-6-17(12)30(18)20-26-28-29-27-20)25-19(31)21(8-9-21)14-4-2-13(3-5-14)15-11-22(15,23)24/h2-5,12,15-18H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	BXVPQQHMZMLJFL-UHFFFAOYSA-N	226484	US20260007684, Compound 37C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226484&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962641	336293586							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136801	C[C@H]1C[C@H](NC(=O)C2(c3ccc(C4CC4(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C22H26F2N6O/c1-12-10-16(18-7-6-17(12)30(18)20-26-28-29-27-20)25-19(31)21(8-9-21)14-4-2-13(3-5-14)15-11-22(15,23)24/h2-5,12,15-18H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	BXVPQQHMZMLJFL-UHFFFAOYSA-N	226485	US20260007684, Compound 37D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226485&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962642	336293587							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136802	O=C(N[C@@H]1CCCN(c2nnn[nH]2)C1)C1(c2ccc(Br)cc2)CC1	InChI=1S/C16H19BrN6O/c17-12-5-3-11(4-6-12)16(7-8-16)14(24)18-13-2-1-9-23(10-13)15-19-21-22-20-15/h3-6,13H,1-2,7-10H2,(H,18,24)(H,19,20,21,22)	MXRIWNNYHCTGFG-UHFFFAOYSA-N	226486	US20260007684, Compound 39A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226486&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962643	336293588							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136803	C[C@@H]1[C@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)CCCN1c1nnn[nH]1	InChI=1S/C17H21ClN6O/c1-11-14(3-2-10-24(11)16-20-22-23-21-16)19-15(25)17(8-9-17)12-4-6-13(18)7-5-12/h4-7,11,14H,2-3,8-10H2,1H3,(H,19,25)(H,20,21,22,23)	BSOSTISDAJEALK-UHFFFAOYSA-N	226487	US20260007684, Compound 40A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226487&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962644	336293589							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136804	C[C@H]3[C@H](NC(=O)C2(c1ccc(Cl)cc1)CC2)CCCN3c4nnn[nH]4	InChI=1S/C17H21ClN6O/c1-11-14(3-2-10-24(11)16-20-22-23-21-16)19-15(25)17(8-9-17)12-4-6-13(18)7-5-12/h4-7,11,14H,2-3,8-10H2,1H3,(H,19,25)(H,20,21,22,23)	BSOSTISDAJEALK-UHFFFAOYSA-N	226488	US20260007684, Compound 40C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226488&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962645	336293590							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136833	C[C@@H]1CC[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)CN1c1nnn[nH]1	InChI=1S/C17H21ClN6O/c1-11-2-7-14(10-24(11)16-20-22-23-21-16)19-15(25)17(8-9-17)12-3-5-13(18)6-4-12/h3-6,11,14H,2,7-10H2,1H3,(H,19,25)(H,20,21,22,23)	RPJCPGAHRQLQQZ-UHFFFAOYSA-N	226489	US20260007684, Compound 41C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226489&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962646	336293591							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136834	CC1(C)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O2/c1-17(2)8-12(9-25(10-17)16-21-23-24-22-16)20-15(27)18(5-6-18)13-4-3-11(19)7-14(13)26/h3-4,7,12,26H,5-6,8-10H2,1-2H3,(H,20,27)(H,21,22,23,24)	WFDAUECEKVNKBN-UHFFFAOYSA-N	226490	(R)-1-(4-chloro-2-hydroxyphenyl)-N-(5,5- dimethyl-1-(1H-tetrazol-5-yl)piperidin-3- yl)cyclopropane-1-carboxamide::US20260007684, Compound 42A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226490&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962647	336293592							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136835	CC1(C)C[C@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O2/c1-17(2)8-12(9-25(10-17)16-21-23-24-22-16)20-15(27)18(5-6-18)13-4-3-11(19)7-14(13)26/h3-4,7,12,26H,5-6,8-10H2,1-2H3,(H,20,27)(H,21,22,23,24)	WFDAUECEKVNKBN-UHFFFAOYSA-N	226491	US20260007684, Compound 42B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226491&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962648	336293593							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136836	C[C@@H]1CC(NC(=O)C2(c3ccc(OC(F)F)cc3O)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O3/c1-10-8-13(15-5-4-14(10)28(15)19-24-26-27-25-19)23-17(30)20(6-7-20)12-3-2-11(9-16(12)29)31-18(21)22/h2-3,9-10,13-15,18,29H,4-8H2,1H3,(H,23,30)(H,24,25,26,27)	JQZDAVAWCAZRKK-UHFFFAOYSA-N	226494	US20260007684, Compound 43A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226494&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962651	336293596							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136837	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3O)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O3/c1-10-8-13(15-5-4-14(10)28(15)19-24-26-27-25-19)23-17(30)20(6-7-20)12-3-2-11(9-16(12)29)31-18(21)22/h2-3,9-10,13-15,18,29H,4-8H2,1H3,(H,23,30)(H,24,25,26,27)	JQZDAVAWCAZRKK-UHFFFAOYSA-N	226495	US20260007684, Compound 43B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226495&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962652	336293597							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136838	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3O)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O3/c1-10-8-13(15-5-4-14(10)28(15)19-24-26-27-25-19)23-17(30)20(6-7-20)12-3-2-11(9-16(12)29)31-18(21)22/h2-3,9-10,13-15,18,29H,4-8H2,1H3,(H,23,30)(H,24,25,26,27)	JQZDAVAWCAZRKK-UHFFFAOYSA-N	226496	US20260007684, Compound 43C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226496&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962653	336293598							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136839	C[C@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3O)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O3/c1-10-8-13(15-5-4-14(10)28(15)19-24-26-27-25-19)23-17(30)20(6-7-20)12-3-2-11(9-16(12)29)31-18(21)22/h2-3,9-10,13-15,18,29H,4-8H2,1H3,(H,23,30)(H,24,25,26,27)	JQZDAVAWCAZRKK-UHFFFAOYSA-N	226497	US20260007684, Compound 43D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226497&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962654	336293599							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136840	O=C(N[C@@H]1C[C@H](F)CN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C16H18ClFN6O/c17-11-3-1-10(2-4-11)16(5-6-16)14(25)19-13-7-12(18)8-24(9-13)15-20-22-23-21-15/h1-4,12-13H,5-9H2,(H,19,25)(H,20,21,22,23)	FYXJRUFWKRUZNR-UHFFFAOYSA-N	226498	US20260007684, Compound 44A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226498&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962655	336293600							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136841	O=C(N[C@@H]1C[C@@H](F)CN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C16H18ClFN6O/c17-11-3-1-10(2-4-11)16(5-6-16)14(25)19-13-7-12(18)8-24(9-13)15-20-22-23-21-15/h1-4,12-13H,5-9H2,(H,19,25)(H,20,21,22,23)	FYXJRUFWKRUZNR-UHFFFAOYSA-N	226499	US20260007684, Compound 44C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226499&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962656	336293601							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136842	O=C(N[C@@H]1C[C@H](C(F)(F)F)CN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C17H18ClF3N6O/c18-12-3-1-10(2-4-12)16(5-6-16)14(28)22-13-7-11(17(19,20)21)8-27(9-13)15-23-25-26-24-15/h1-4,11,13H,5-9H2,(H,22,28)(H,23,24,25,26)	UDYULUBALKCFDY-UHFFFAOYSA-N	226500	US20260007684, Compound 45A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226500&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962657	336293602							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136843	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C17H21ClN6O/c1-11-8-14(10-24(9-11)16-20-22-23-21-16)19-15(25)17(6-7-17)12-2-4-13(18)5-3-12/h2-5,11,14H,6-10H2,1H3,(H,19,25)(H,20,21,22,23)	AUMOFTLPIFMXOV-UHFFFAOYSA-N	226501	1-(4-chlorophenyl)-N-((3R,5S)-5-methyl-1- (1H-tetrazol-5-yl)piperidin-3- yl)cyclopropane-1-carboxamide::US20260007684, Compound 46A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226501&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962658	336293603							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136844	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C17H21ClN6O/c1-11-8-14(10-24(9-11)16-20-22-23-21-16)19-15(25)17(6-7-17)12-2-4-13(18)5-3-12/h2-5,11,14H,6-10H2,1H3,(H,19,25)(H,20,21,22,23)	AUMOFTLPIFMXOV-UHFFFAOYSA-N	226503	US20260007684, Compound 46C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226503&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962660	336293605							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136845	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C17H21ClN6O2/c1-10-6-12(9-24(8-10)16-20-22-23-21-16)19-15(26)17(4-5-17)13-3-2-11(18)7-14(13)25/h2-3,7,10,12,25H,4-6,8-9H2,1H3,(H,19,26)(H,20,21,22,23)	AXCDISYORWMTTC-UHFFFAOYSA-N	226504	1-(4-chloro-2-hydroxyphenyl)-N-((3R,5S)- 5-methyl-1-(1H-tetrazol-5-yl)piperidin-3- yl)cyclopropane-1-carboxamide::US20260007684, Compound 47A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226504&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962661	336293606							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136846	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H22F2N6O2/c1-10-6-12(9-26(8-10)17-22-24-25-23-17)21-16(28)18(4-5-18)13-3-2-11(15(19)20)7-14(13)27/h2-3,7,10,12,15,27H,4-6,8-9H2,1H3,(H,21,28)(H,22,23,24,25)	GXKRXPMYIZLCRE-UHFFFAOYSA-N	226505	US20260007684, Compound 48A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226505&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962662	336293607							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136847	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H]1NC(=O)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C17H21ClN6O/c1-11-6-9-24(16-20-22-23-21-16)10-14(11)19-15(25)17(7-8-17)12-2-4-13(18)5-3-12/h2-5,11,14H,6-10H2,1H3,(H,19,25)(H,20,21,22,23)	WJXXSRMZCOPCSW-UHFFFAOYSA-N	226506	US20260007684, Compound 49A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226506&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962663	336293608							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136848	C[C@H]1CCN(c2nnn[nH]2)C[C@@H]1NC(=O)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C17H21ClN6O/c1-11-6-9-24(16-20-22-23-21-16)10-14(11)19-15(25)17(7-8-17)12-2-4-13(18)5-3-12/h2-5,11,14H,6-10H2,1H3,(H,19,25)(H,20,21,22,23)	WJXXSRMZCOPCSW-UHFFFAOYSA-N	226507	US20260007684, Compound 49C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226507&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962664	336293609							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136849	O=C(N[C@H]1CN(c2nnn[nH]2)CC[C@H]1F)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C16H18ClFN6O/c17-11-3-1-10(2-4-11)16(6-7-16)14(25)19-13-9-24(8-5-12(13)18)15-20-22-23-21-15/h1-4,12-13H,5-9H2,(H,19,25)(H,20,21,22,23)	PLTLGBCMRVBSJO-UHFFFAOYSA-N	226508	US20260007684, Compound 50A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226508&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962665	336293610							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136850	O=C(N[C@H]1CN(c2nnn[nH]2)CC[C@@H]1F)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C16H18ClFN6O/c17-11-3-1-10(2-4-11)16(6-7-16)14(25)19-13-9-24(8-5-12(13)18)15-20-22-23-21-15/h1-4,12-13H,5-9H2,(H,19,25)(H,20,21,22,23)	PLTLGBCMRVBSJO-UHFFFAOYSA-N	226509	US20260007684, Compound 50C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226509&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962666	336293611							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136851	O=C(N[C@@H]1CCCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C17H21ClN6O/c18-13-6-4-12(5-7-13)17(8-9-17)15(25)19-14-3-1-2-10-24(11-14)16-20-22-23-21-16/h4-7,14H,1-3,8-11H2,(H,19,25)(H,20,21,22,23)	AOLWXRZIMIKCKO-UHFFFAOYSA-N	226510	1-(4-chlorophenyl)-N-[(3R)-1-(1H-tetrazol- 5-yl)azepan-3-yl]cyclopropanecarboxamide::US20260007684, Compound 51A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226510&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962667	336293612							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136852	O=C(N[C@@H]1CCCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C17H21ClN6O2/c18-11-4-5-13(14(25)9-11)17(6-7-17)15(26)19-12-3-1-2-8-24(10-12)16-20-22-23-21-16/h4-5,9,12,25H,1-3,6-8,10H2,(H,19,26)(H,20,21,22,23)	YBXVHCUTLYGFTE-UHFFFAOYSA-N	226511	(R)-N-(1-(1H-tetrazol-5-yl)azepan-3-yl)-1- (4-chloro-2-hydroxyphenyl)cyclopropane-1- carboxamide::US20260007684, Compound 52A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226511&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962668	336293613							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136853	O=C(N[C@H]1CN(c2nnn[nH]2)CCC(F)(F)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C17H19ClF2N6O/c18-12-3-1-11(2-4-12)16(5-6-16)14(27)21-13-9-17(19,20)7-8-26(10-13)15-22-24-25-23-15/h1-4,13H,5-10H2,(H,21,27)(H,22,23,24,25)	HSXHNQBUJLXSTO-UHFFFAOYSA-N	226512	US20260007684, Compound 53A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226512&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962669	336293614							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136854	O=C(N[C@@H]1CN(c2nnn[nH]2)CCC(F)(F)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C17H19ClF2N6O/c18-12-3-1-11(2-4-12)16(5-6-16)14(27)21-13-9-17(19,20)7-8-26(10-13)15-22-24-25-23-15/h1-4,13H,5-10H2,(H,21,27)(H,22,23,24,25)	HSXHNQBUJLXSTO-UHFFFAOYSA-N	226513	US20260007684, Compound 53B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226513&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962670	336293615							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136855	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)c(OC(F)F)c3)CC2)C1	InChI=1S/C20H23F5N6O2/c1-11-4-7-31(18-27-29-30-28-18)10-13(8-11)26-16(32)19(5-6-19)12-2-3-14(20(23,24)25)15(9-12)33-17(21)22/h2-3,9,11,13,17H,4-8,10H2,1H3,(H,26,32)(H,27,28,29,30)	ROTYLGUHYZQEHS-UHFFFAOYSA-N	226514	US20260007684, Compound 54A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226514&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962671	336293616							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136856	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)c(OC(F)F)c3)CC2)C1	InChI=1S/C20H23F5N6O2/c1-11-4-7-31(18-27-29-30-28-18)10-13(8-11)26-16(32)19(5-6-19)12-2-3-14(20(23,24)25)15(9-12)33-17(21)22/h2-3,9,11,13,17H,4-8,10H2,1H3,(H,26,32)(H,27,28,29,30)	ROTYLGUHYZQEHS-UHFFFAOYSA-N	226515	US20260007684, Compound 54B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226515&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962672	336293617							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136857	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)c(OC(F)F)c3)CC2)C1	InChI=1S/C20H23F5N6O2/c1-11-4-7-31(18-27-29-30-28-18)10-13(8-11)26-16(32)19(5-6-19)12-2-3-14(20(23,24)25)15(9-12)33-17(21)22/h2-3,9,11,13,17H,4-8,10H2,1H3,(H,26,32)(H,27,28,29,30)	ROTYLGUHYZQEHS-UHFFFAOYSA-N	226516	US20260007684, Compound 54C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226516&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962673	336293618							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136858	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)c(OC(F)F)c3)CC2)C1	InChI=1S/C20H23F5N6O2/c1-11-4-7-31(18-27-29-30-28-18)10-13(8-11)26-16(32)19(5-6-19)12-2-3-14(20(23,24)25)15(9-12)33-17(21)22/h2-3,9,11,13,17H,4-8,10H2,1H3,(H,26,32)(H,27,28,29,30)	ROTYLGUHYZQEHS-UHFFFAOYSA-N	226517	US20260007684, Compound 54D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226517&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962674	336293619							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136859	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)cc3Cl)CC2)C1	InChI=1S/C18H22Cl2N6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)14-3-2-12(19)9-15(14)20/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	BMZXFBHJIRGOPT-UHFFFAOYSA-N	226518	US20260007684, Compound 55A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226518&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962675	336293620							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136860	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3Cl)CC2)C1	InChI=1S/C18H22Cl2N6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)14-3-2-12(19)9-15(14)20/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	BMZXFBHJIRGOPT-UHFFFAOYSA-N	226519	US20260007684, Compound 55B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226519&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962676	336293621							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136861	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)cc3Cl)CC2)C1	InChI=1S/C18H22Cl2N6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)14-3-2-12(19)9-15(14)20/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	BMZXFBHJIRGOPT-UHFFFAOYSA-N	226520	US20260007684, Compound 55C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226520&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962677	336293622							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136862	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3Cl)CC2)C1	InChI=1S/C18H22Cl2N6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)14-3-2-12(19)9-15(14)20/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	BMZXFBHJIRGOPT-UHFFFAOYSA-N	226521	US20260007684, Compound 55D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226521&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962678	336293623							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136863	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)cc3F)CC2)C1	InChI=1S/C18H22ClFN6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)14-3-2-12(19)9-15(14)20/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	GDXXLGQFEXXCTE-UHFFFAOYSA-N	226522	US20260007684, Compound 56A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226522&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962679	336293624					C04080		1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136864	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3F)CC2)C1	InChI=1S/C18H22ClFN6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)14-3-2-12(19)9-15(14)20/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	GDXXLGQFEXXCTE-UHFFFAOYSA-N	226523	US20260007684, Compound 56B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226523&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962680	336293625							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136865	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)cc3F)CC2)C1	InChI=1S/C18H22ClFN6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)14-3-2-12(19)9-15(14)20/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	GDXXLGQFEXXCTE-UHFFFAOYSA-N	226524	US20260007684, Compound 56C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226524&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962681	336293626							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136866	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3F)CC2)C1	InChI=1S/C18H22ClFN6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)14-3-2-12(19)9-15(14)20/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	GDXXLGQFEXXCTE-UHFFFAOYSA-N	226525	US20260007684, Compound 56D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226525&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962682	336293627							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136867	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6O2/c1-12-6-9-28(17-24-26-27-25-17)11-14(10-12)23-16(29)18(7-8-18)13-2-4-15(5-3-13)30-19(20,21)22/h2-5,12,14H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	AIRGACWPLQLDJC-UHFFFAOYSA-N	226526	US20260007684, Compound 57A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226526&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962683	336293628							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136868	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6O2/c1-12-6-9-28(17-24-26-27-25-17)11-14(10-12)23-16(29)18(7-8-18)13-2-4-15(5-3-13)30-19(20,21)22/h2-5,12,14H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	AIRGACWPLQLDJC-UHFFFAOYSA-N	226527	US20260007684, Compound 57B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226527&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962684	336293629							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136869	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6O2/c1-12-6-9-28(17-24-26-27-25-17)11-14(10-12)23-16(29)18(7-8-18)13-2-4-15(5-3-13)30-19(20,21)22/h2-5,12,14H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	AIRGACWPLQLDJC-UHFFFAOYSA-N	226528	US20260007684, Compound 57C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226528&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962685	336293630							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136870	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6O2/c1-12-6-9-28(17-24-26-27-25-17)11-14(10-12)23-16(29)18(7-8-18)13-2-4-15(5-3-13)30-19(20,21)22/h2-5,12,14H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	AIRGACWPLQLDJC-UHFFFAOYSA-N	226529	US20260007684, Compound 57D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226529&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962686	336293631							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136871	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)C1	InChI=1S/C19H24F2N6O2/c1-12-6-9-27(18-23-25-26-24-18)11-14(10-12)22-16(28)19(7-8-19)13-2-4-15(5-3-13)29-17(20)21/h2-5,12,14,17H,6-11H2,1H3,(H,22,28)(H,23,24,25,26)	DYSXYFCKTVLXPQ-UHFFFAOYSA-N	226530	US20260007684, Compound 58A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226530&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962687	336293632							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136872	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)C1	InChI=1S/C19H24F2N6O2/c1-12-6-9-27(18-23-25-26-24-18)11-14(10-12)22-16(28)19(7-8-19)13-2-4-15(5-3-13)29-17(20)21/h2-5,12,14,17H,6-11H2,1H3,(H,22,28)(H,23,24,25,26)	DYSXYFCKTVLXPQ-UHFFFAOYSA-N	226531	US20260007684, Compound 58B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226531&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962688	336293633							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136873	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)C1	InChI=1S/C19H24F2N6O2/c1-12-6-9-27(18-23-25-26-24-18)11-14(10-12)22-16(28)19(7-8-19)13-2-4-15(5-3-13)29-17(20)21/h2-5,12,14,17H,6-11H2,1H3,(H,22,28)(H,23,24,25,26)	DYSXYFCKTVLXPQ-UHFFFAOYSA-N	226532	US20260007684, Compound 58C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226532&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962689	336293634							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136874	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3)CC2)C1	InChI=1S/C19H24F2N6O2/c1-12-6-9-27(18-23-25-26-24-18)11-14(10-12)22-16(28)19(7-8-19)13-2-4-15(5-3-13)29-17(20)21/h2-5,12,14,17H,6-11H2,1H3,(H,22,28)(H,23,24,25,26)	DYSXYFCKTVLXPQ-UHFFFAOYSA-N	226533	US20260007684, Compound 58D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226533&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962690	336293635							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136875	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Br)cc3)CC2)C1	InChI=1S/C18H23BrN6O/c1-12-6-9-25(17-21-23-24-22-17)11-15(10-12)20-16(26)18(7-8-18)13-2-4-14(19)5-3-13/h2-5,12,15H,6-11H2,1H3,(H,20,26)(H,21,22,23,24)	IUWHCDVFUPHALA-UHFFFAOYSA-N	226534	US20260007684, Compound 59A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226534&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962691	336293636							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136876	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Br)cc3)CC2)C1	InChI=1S/C18H23BrN6O/c1-12-6-9-25(17-21-23-24-22-17)11-15(10-12)20-16(26)18(7-8-18)13-2-4-14(19)5-3-13/h2-5,12,15H,6-11H2,1H3,(H,20,26)(H,21,22,23,24)	IUWHCDVFUPHALA-UHFFFAOYSA-N	226535	US20260007684, Compound 59B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226535&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962692	336293637							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136877	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Br)cc3)CC2)C1	InChI=1S/C18H23BrN6O/c1-12-6-9-25(17-21-23-24-22-17)11-15(10-12)20-16(26)18(7-8-18)13-2-4-14(19)5-3-13/h2-5,12,15H,6-11H2,1H3,(H,20,26)(H,21,22,23,24)	IUWHCDVFUPHALA-UHFFFAOYSA-N	226536	US20260007684, Compound 59C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226536&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962693	336293638							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136878	C[C@H]1CCCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Br)cc3)CC2)C1	InChI=1S/C19H25BrN6O/c1-13-3-2-10-26(18-22-24-25-23-18)12-16(11-13)21-17(27)19(8-9-19)14-4-6-15(20)7-5-14/h4-7,13,16H,2-3,8-12H2,1H3,(H,21,27)(H,22,23,24,25)	XIPMVZLQADAMCS-UHFFFAOYSA-N	226537	US20260007684, Compound 59D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226537&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962694	336293639							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136879	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)C1	InChI=1S/C18H23ClN6O2/c1-11-4-7-25(17-21-23-24-22-17)10-13(8-11)20-16(27)18(5-6-18)14-3-2-12(19)9-15(14)26/h2-3,9,11,13,26H,4-8,10H2,1H3,(H,20,27)(H,21,22,23,24)	JYPZWLLMEIIFMB-UHFFFAOYSA-N	226538	US20260007684, Compound 60A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226538&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962695	336293640							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136880	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)C1	InChI=1S/C18H23ClN6O2/c1-11-4-7-25(17-21-23-24-22-17)10-13(8-11)20-16(27)18(5-6-18)14-3-2-12(19)9-15(14)26/h2-3,9,11,13,26H,4-8,10H2,1H3,(H,20,27)(H,21,22,23,24)	JYPZWLLMEIIFMB-UHFFFAOYSA-N	226539	US20260007684, Compound 60B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226539&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962696	336293641							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136881	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)C1	InChI=1S/C18H23ClN6O2/c1-11-4-7-25(17-21-23-24-22-17)10-13(8-11)20-16(27)18(5-6-18)14-3-2-12(19)9-15(14)26/h2-3,9,11,13,26H,4-8,10H2,1H3,(H,20,27)(H,21,22,23,24)	JYPZWLLMEIIFMB-UHFFFAOYSA-N	226540	US20260007684, Compound 60C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226540&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962697	336293642							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136882	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)C1	InChI=1S/C18H23ClN6O2/c1-11-4-7-25(17-21-23-24-22-17)10-13(8-11)20-16(27)18(5-6-18)14-3-2-12(19)9-15(14)26/h2-3,9,11,13,26H,4-8,10H2,1H3,(H,20,27)(H,21,22,23,24)	JYPZWLLMEIIFMB-UHFFFAOYSA-N	226541	US20260007684, Compound 60D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226541&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962698	336293643							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136883	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6O/c1-12-6-9-28(17-24-26-27-25-17)11-15(10-12)23-16(29)18(7-8-18)13-2-4-14(5-3-13)19(20,21)22/h2-5,12,15H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	BNYDLFNCRORTCS-UHFFFAOYSA-N	226542	US20260007684, Compound 61A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226542&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962699	336293644							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136884	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6O/c1-12-6-9-28(17-24-26-27-25-17)11-15(10-12)23-16(29)18(7-8-18)13-2-4-14(5-3-13)19(20,21)22/h2-5,12,15H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	BNYDLFNCRORTCS-UHFFFAOYSA-N	226543	US20260007684, Compound 61B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226543&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962700	336293645							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136885	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6O/c1-12-6-9-28(17-24-26-27-25-17)11-15(10-12)23-16(29)18(7-8-18)13-2-4-14(5-3-13)19(20,21)22/h2-5,12,15H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	BNYDLFNCRORTCS-UHFFFAOYSA-N	226544	US20260007684, Compound 61C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226544&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962701	336293646							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136886	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6O/c1-12-6-9-28(17-24-26-27-25-17)11-15(10-12)23-16(29)18(7-8-18)13-2-4-14(5-3-13)19(20,21)22/h2-5,12,15H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	BNYDLFNCRORTCS-UHFFFAOYSA-N	226545	US20260007684, Compound 61D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226545&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962702	336293647							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136887	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3O)CC2)C1	InChI=1S/C19H23F3N6O3/c1-11-4-7-28(17-24-26-27-25-17)10-12(8-11)23-16(30)18(5-6-18)14-3-2-13(9-15(14)29)31-19(20,21)22/h2-3,9,11-12,29H,4-8,10H2,1H3,(H,23,30)(H,24,25,26,27)	XUKGCOHNXGISFF-UHFFFAOYSA-N	226546	US20260007684, Compound 62A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226546&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962703	336293648							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136888	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3O)CC2)C1	InChI=1S/C19H23F3N6O3/c1-11-4-7-28(17-24-26-27-25-17)10-12(8-11)23-16(30)18(5-6-18)14-3-2-13(9-15(14)29)31-19(20,21)22/h2-3,9,11-12,29H,4-8,10H2,1H3,(H,23,30)(H,24,25,26,27)	XUKGCOHNXGISFF-UHFFFAOYSA-N	226547	US20260007684, Compound 62B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226547&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962704	336293649							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136889	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3O)CC2)C1	InChI=1S/C19H23F3N6O3/c1-11-4-7-28(17-24-26-27-25-17)10-12(8-11)23-16(30)18(5-6-18)14-3-2-13(9-15(14)29)31-19(20,21)22/h2-3,9,11-12,29H,4-8,10H2,1H3,(H,23,30)(H,24,25,26,27)	XUKGCOHNXGISFF-UHFFFAOYSA-N	226548	US20260007684, Compound 62C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226548&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962705	336293650							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136890	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3O)CC2)C1	InChI=1S/C19H23F3N6O3/c1-11-4-7-28(17-24-26-27-25-17)10-12(8-11)23-16(30)18(5-6-18)14-3-2-13(9-15(14)29)31-19(20,21)22/h2-3,9,11-12,29H,4-8,10H2,1H3,(H,23,30)(H,24,25,26,27)	XUKGCOHNXGISFF-UHFFFAOYSA-N	226549	US20260007684, Compound 62D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226549&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962706	336293651							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136891	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)C1	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(17-24-26-27-25-17)10-13(8-11)23-16(30)18(5-6-18)14-3-2-12(9-15(14)29)19(20,21)22/h2-3,9,11,13,29H,4-8,10H2,1H3,(H,23,30)(H,24,25,26,27)	AXLDLXBDJWDYDE-UHFFFAOYSA-N	226550	US20260007684, Compound 63A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226550&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962707	336293652							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136892	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)C1	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(17-24-26-27-25-17)10-13(8-11)23-16(30)18(5-6-18)14-3-2-12(9-15(14)29)19(20,21)22/h2-3,9,11,13,29H,4-8,10H2,1H3,(H,23,30)(H,24,25,26,27)	AXLDLXBDJWDYDE-UHFFFAOYSA-N	226551	US20260007684, Compound 63B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226551&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962708	336293653							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136893	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)C1	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(17-24-26-27-25-17)10-13(8-11)23-16(30)18(5-6-18)14-3-2-12(9-15(14)29)19(20,21)22/h2-3,9,11,13,29H,4-8,10H2,1H3,(H,23,30)(H,24,25,26,27)	AXLDLXBDJWDYDE-UHFFFAOYSA-N	226552	US20260007684, Compound 63C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226552&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962709	336293654							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136894	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)C1	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(17-24-26-27-25-17)10-13(8-11)23-16(30)18(5-6-18)14-3-2-12(9-15(14)29)19(20,21)22/h2-3,9,11,13,29H,4-8,10H2,1H3,(H,23,30)(H,24,25,26,27)	AXLDLXBDJWDYDE-UHFFFAOYSA-N	226553	US20260007684, Compound 63D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226553&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962710	336293655							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136895	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H22F4N6O2/c1-11-4-7-29(17-25-27-28-26-17)10-12(8-11)24-16(30)18(5-6-18)14-3-2-13(9-15(14)20)31-19(21,22)23/h2-3,9,11-12H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	WLWHKPKXARKTMW-UHFFFAOYSA-N	226554	US20260007684, Compound 64A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226554&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962711	336293656							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136896	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H22F4N6O2/c1-11-4-7-29(17-25-27-28-26-17)10-12(8-11)24-16(30)18(5-6-18)14-3-2-13(9-15(14)20)31-19(21,22)23/h2-3,9,11-12H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	WLWHKPKXARKTMW-UHFFFAOYSA-N	226555	US20260007684, Compound 64B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226555&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962712	336293657							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136897	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H22F4N6O2/c1-11-4-7-29(17-25-27-28-26-17)10-12(8-11)24-16(30)18(5-6-18)14-3-2-13(9-15(14)20)31-19(21,22)23/h2-3,9,11-12H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	WLWHKPKXARKTMW-UHFFFAOYSA-N	226556	US20260007684, Compound 64C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226556&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962713	336293658							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136898	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H22F4N6O2/c1-11-4-7-29(17-25-27-28-26-17)10-12(8-11)24-16(30)18(5-6-18)14-3-2-13(9-15(14)20)31-19(21,22)23/h2-3,9,11-12H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	WLWHKPKXARKTMW-UHFFFAOYSA-N	226557	US20260007684, Compound 64D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226557&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962714	336293659							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136899	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)c(F)c3)CC2)C1	InChI=1S/C18H22ClFN6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)12-2-3-14(19)15(20)9-12/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	LRGZERZZHBJLPL-UHFFFAOYSA-N	226558	US20260007684, Compound 65A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226558&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962715	336293660							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136900	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)c(F)c3)CC2)C1	InChI=1S/C18H22ClFN6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)12-2-3-14(19)15(20)9-12/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	LRGZERZZHBJLPL-UHFFFAOYSA-N	226559	US20260007684, Compound 65B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226559&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962716	336293661							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136901	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)c(F)c3)CC2)C1	InChI=1S/C18H22ClFN6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)12-2-3-14(19)15(20)9-12/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	LRGZERZZHBJLPL-UHFFFAOYSA-N	226560	US20260007684, Compound 65C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226560&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962717	336293662							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136902	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3F)CC2)C1	InChI=1S/C18H22ClFN6O/c1-11-4-7-26(17-22-24-25-23-17)10-13(8-11)21-16(27)18(5-6-18)14-3-2-12(19)9-15(14)20/h2-3,9,11,13H,4-8,10H2,1H3,(H,21,27)(H,22,23,24,25)	GDXXLGQFEXXCTE-UHFFFAOYSA-N	226561	US20260007684, Compound 65D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226561&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962718	336293663							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136903	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)c(F)c3)CC2)C1	InChI=1S/C19H22F4N6O/c1-11-4-7-29(17-25-27-28-26-17)10-13(8-11)24-16(30)18(5-6-18)12-2-3-14(15(20)9-12)19(21,22)23/h2-3,9,11,13H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	YBLSPTPWSBMAIQ-UHFFFAOYSA-N	226562	US20260007684, Compound 66A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226562&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962719	336293664							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136904	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)c(F)c3)CC2)C1	InChI=1S/C19H22F4N6O/c1-11-4-7-29(17-25-27-28-26-17)10-13(8-11)24-16(30)18(5-6-18)12-2-3-14(15(20)9-12)19(21,22)23/h2-3,9,11,13H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	YBLSPTPWSBMAIQ-UHFFFAOYSA-N	226564	US20260007684, Compound 66B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226564&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962720	336293665							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136905	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)c(F)c3)CC2)C1	InChI=1S/C19H22F4N6O/c1-11-4-7-29(17-25-27-28-26-17)10-13(8-11)24-16(30)18(5-6-18)12-2-3-14(15(20)9-12)19(21,22)23/h2-3,9,11,13H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	YBLSPTPWSBMAIQ-UHFFFAOYSA-N	226565	US20260007684, Compound 66C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226565&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962721	336293666							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136906	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)c(F)c3)CC2)C1	InChI=1S/C19H22F4N6O/c1-11-4-7-29(17-25-27-28-26-17)10-13(8-11)24-16(30)18(5-6-18)12-2-3-14(15(20)9-12)19(21,22)23/h2-3,9,11,13H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	YBLSPTPWSBMAIQ-UHFFFAOYSA-N	226566	US20260007684, Compound 66D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226566&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962722	336293667							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136907	Cc1ccc(C2(C(=O)N[C@@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1	InChI=1S/C19H26N6O2/c1-12-3-4-15(16(26)10-12)19(6-7-19)17(27)20-14-9-13(2)5-8-25(11-14)18-21-23-24-22-18/h3-4,10,13-14,26H,5-9,11H2,1-2H3,(H,20,27)(H,21,22,23,24)	SEZVOLVOXWBCKS-UHFFFAOYSA-N	226567	US20260007684, Compound 67A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226567&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962723	336293668							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136908	Cc1ccc(C2(C(=O)N[C@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1	InChI=1S/C19H26N6O2/c1-12-3-4-15(16(26)10-12)19(6-7-19)17(27)20-14-9-13(2)5-8-25(11-14)18-21-23-24-22-18/h3-4,10,13-14,26H,5-9,11H2,1-2H3,(H,20,27)(H,21,22,23,24)	SEZVOLVOXWBCKS-UHFFFAOYSA-N	226568	US20260007684, Compound 67B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226568&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962724	336293669							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136909	Cc1ccc(C2(C(=O)N[C@@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1	InChI=1S/C19H26N6O2/c1-12-3-4-15(16(26)10-12)19(6-7-19)17(27)20-14-9-13(2)5-8-25(11-14)18-21-23-24-22-18/h3-4,10,13-14,26H,5-9,11H2,1-2H3,(H,20,27)(H,21,22,23,24)	SEZVOLVOXWBCKS-UHFFFAOYSA-N	226569	US20260007684, Compound 67C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226569&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962725	336293670							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136910	Cc1ccc(C2(C(=O)N[C@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1	InChI=1S/C19H26N6O2/c1-12-3-4-15(16(26)10-12)19(6-7-19)17(27)20-14-9-13(2)5-8-25(11-14)18-21-23-24-22-18/h3-4,10,13-14,26H,5-9,11H2,1-2H3,(H,20,27)(H,21,22,23,24)	SEZVOLVOXWBCKS-UHFFFAOYSA-N	226570	US20260007684, Compound 67D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226570&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962726	336293671							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136911	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H22F4N6O/c1-11-4-7-29(17-25-27-28-26-17)10-13(8-11)24-16(30)18(5-6-18)14-3-2-12(9-15(14)20)19(21,22)23/h2-3,9,11,13H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	LCVXUPWQAVIKGO-UHFFFAOYSA-N	226571	US20260007684, Compound 68A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226571&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962727	336293672							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136912	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H22F4N6O/c1-11-4-7-29(17-25-27-28-26-17)10-13(8-11)24-16(30)18(5-6-18)14-3-2-12(9-15(14)20)19(21,22)23/h2-3,9,11,13H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	LCVXUPWQAVIKGO-UHFFFAOYSA-N	226572	US20260007684, Compound 68B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226572&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962728	336293673							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136913	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H22F4N6O2/c1-11-4-7-29(17-25-27-28-26-17)10-12(8-11)24-16(30)18(5-6-18)14-3-2-13(9-15(14)20)31-19(21,22)23/h2-3,9,11-12H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	WLWHKPKXARKTMW-UHFFFAOYSA-N	226573	US20260007684, Compound 68C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226573&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962729	336293674							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136914	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3F)CC2)C1	InChI=1S/C19H22F4N6O/c1-11-4-7-29(17-25-27-28-26-17)10-13(8-11)24-16(30)18(5-6-18)14-3-2-12(9-15(14)20)19(21,22)23/h2-3,9,11,13H,4-8,10H2,1H3,(H,24,30)(H,25,26,27,28)	LCVXUPWQAVIKGO-UHFFFAOYSA-N	226574	US20260007684, Compound 68D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226574&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962730	336293675							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136915	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(SC(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6OS/c1-12-6-9-28(17-24-26-27-25-17)11-14(10-12)23-16(29)18(7-8-18)13-2-4-15(5-3-13)30-19(20,21)22/h2-5,12,14H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	XEWVDHDKPSEPOU-UHFFFAOYSA-N	226575	US20260007684, Compound 69A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226575&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962731	336293676							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136916	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(SC(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6OS/c1-12-6-9-28(17-24-26-27-25-17)11-14(10-12)23-16(29)18(7-8-18)13-2-4-15(5-3-13)30-19(20,21)22/h2-5,12,14H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	XEWVDHDKPSEPOU-UHFFFAOYSA-N	226576	US20260007684, Compound 69B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226576&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962732	336293677							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136917	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(SC(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6OS/c1-12-6-9-28(17-24-26-27-25-17)11-14(10-12)23-16(29)18(7-8-18)13-2-4-15(5-3-13)30-19(20,21)22/h2-5,12,14H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	XEWVDHDKPSEPOU-UHFFFAOYSA-N	226577	US20260007684, Compound 69C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226577&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962733	336293678							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136918	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(SC(F)(F)F)cc3)CC2)C1	InChI=1S/C19H23F3N6OS/c1-12-6-9-28(17-24-26-27-25-17)11-14(10-12)23-16(29)18(7-8-18)13-2-4-15(5-3-13)30-19(20,21)22/h2-5,12,14H,6-11H2,1H3,(H,23,29)(H,24,25,26,27)	XEWVDHDKPSEPOU-UHFFFAOYSA-N	226578	US20260007684, Compound 69D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226578&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962734	336293679							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136919	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3O)CC2)C1	InChI=1S/C19H24F2N6O3/c1-11-4-7-27(18-23-25-26-24-18)10-12(8-11)22-16(29)19(5-6-19)14-3-2-13(9-15(14)28)30-17(20)21/h2-3,9,11-12,17,28H,4-8,10H2,1H3,(H,22,29)(H,23,24,25,26)	RXXNOCBYXUFJKJ-UHFFFAOYSA-N	226579	US20260007684, Compound 70A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226579&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962735	336293680							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136920	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3O)CC2)C1	InChI=1S/C19H24F2N6O3/c1-11-4-7-27(18-23-25-26-24-18)10-12(8-11)22-16(29)19(5-6-19)14-3-2-13(9-15(14)28)30-17(20)21/h2-3,9,11-12,17,28H,4-8,10H2,1H3,(H,22,29)(H,23,24,25,26)	RXXNOCBYXUFJKJ-UHFFFAOYSA-N	226580	US20260007684, Compound 70B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226580&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962736	336293681							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136921	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3O)CC2)C1	InChI=1S/C19H24F2N6O3/c1-11-4-7-27(18-23-25-26-24-18)10-12(8-11)22-16(29)19(5-6-19)14-3-2-13(9-15(14)28)30-17(20)21/h2-3,9,11-12,17,28H,4-8,10H2,1H3,(H,22,29)(H,23,24,25,26)	RXXNOCBYXUFJKJ-UHFFFAOYSA-N	226581	US20260007684, Compound 70C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226581&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962737	336293682							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136922	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3O)CC2)C1	InChI=1S/C19H24F2N6O3/c1-11-4-7-27(18-23-25-26-24-18)10-12(8-11)22-16(29)19(5-6-19)14-3-2-13(9-15(14)28)30-17(20)21/h2-3,9,11-12,17,28H,4-8,10H2,1H3,(H,22,29)(H,23,24,25,26)	RXXNOCBYXUFJKJ-UHFFFAOYSA-N	226582	US20260007684, Compound 70D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226582&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962738	336293683							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136923	Cc1ccc(C2(C(=O)N[C@@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)cc1	InChI=1S/C19H26N6O/c1-13-3-5-15(6-4-13)19(8-9-19)17(26)20-16-11-14(2)7-10-25(12-16)18-21-23-24-22-18/h3-6,14,16H,7-12H2,1-2H3,(H,20,26)(H,21,22,23,24)	YUGYXUAYOXXBTR-UHFFFAOYSA-N	226583	US20260007684, Compound 71A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226583&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962739	336293684							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136924	Cc1ccc(C2(C(=O)N[C@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)cc1	InChI=1S/C19H26N6O/c1-13-3-5-15(6-4-13)19(8-9-19)17(26)20-16-11-14(2)7-10-25(12-16)18-21-23-24-22-18/h3-6,14,16H,7-12H2,1-2H3,(H,20,26)(H,21,22,23,24)	YUGYXUAYOXXBTR-UHFFFAOYSA-N	226584	US20260007684, Compound 71B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226584&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962740	336293685							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136925	Cc1ccc(C2(C(=O)N[C@@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)cc1	InChI=1S/C19H26N6O/c1-13-3-5-15(6-4-13)19(8-9-19)17(26)20-16-11-14(2)7-10-25(12-16)18-21-23-24-22-18/h3-6,14,16H,7-12H2,1-2H3,(H,20,26)(H,21,22,23,24)	YUGYXUAYOXXBTR-UHFFFAOYSA-N	226585	US20260007684, Compound 71C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226585&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962741	336293686							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136926	Cc1ccc(C2(C(=O)N[C@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)cc1	InChI=1S/C19H26N6O/c1-13-3-5-15(6-4-13)19(8-9-19)17(26)20-16-11-14(2)7-10-25(12-16)18-21-23-24-22-18/h3-6,14,16H,7-12H2,1-2H3,(H,20,26)(H,21,22,23,24)	YUGYXUAYOXXBTR-UHFFFAOYSA-N	226586	US20260007684, Compound 71D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226586&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962742	336293687							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136927	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3c(F)cc(Cl)cc3F)CC2)C1	InChI=1S/C18H21ClF2N6O/c1-10-2-5-27(17-23-25-26-24-17)9-12(6-10)22-16(28)18(3-4-18)15-13(20)7-11(19)8-14(15)21/h7-8,10,12H,2-6,9H2,1H3,(H,22,28)(H,23,24,25,26)	KQELUBIASTZYCA-UHFFFAOYSA-N	226587	US20260007684, Compound 72A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226587&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962743	336293688							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136928	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3c(F)cc(Cl)cc3F)CC2)C1	InChI=1S/C18H21ClF2N6O/c1-10-2-5-27(17-23-25-26-24-17)9-12(6-10)22-16(28)18(3-4-18)15-13(20)7-11(19)8-14(15)21/h7-8,10,12H,2-6,9H2,1H3,(H,22,28)(H,23,24,25,26)	KQELUBIASTZYCA-UHFFFAOYSA-N	226588	US20260007684, Compound 72B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226588&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962744	336293689							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136929	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3c(F)cc(Cl)cc3F)CC2)C1	InChI=1S/C18H21ClF2N6O/c1-10-2-5-27(17-23-25-26-24-17)9-12(6-10)22-16(28)18(3-4-18)15-13(20)7-11(19)8-14(15)21/h7-8,10,12H,2-6,9H2,1H3,(H,22,28)(H,23,24,25,26)	KQELUBIASTZYCA-UHFFFAOYSA-N	226589	US20260007684, Compound 72C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226589&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962745	336293690							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136930	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3c(F)cc(Cl)cc3F)CC2)C1	InChI=1S/C18H21ClF2N6O/c1-10-2-5-27(17-23-25-26-24-17)9-12(6-10)22-16(28)18(3-4-18)15-13(20)7-11(19)8-14(15)21/h7-8,10,12H,2-6,9H2,1H3,(H,22,28)(H,23,24,25,26)	KQELUBIASTZYCA-UHFFFAOYSA-N	226590	US20260007684, Compound 72D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226590&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962746	336293691							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136931	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)F)c(F)c3)CC2)C1	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(18-24-26-27-25-18)10-13(8-11)23-16(29)19(5-6-19)12-2-3-15(14(20)9-12)30-17(21)22/h2-3,9,11,13,17H,4-8,10H2,1H3,(H,23,29)(H,24,25,26,27)	XBXUWWVJMGOGEZ-UHFFFAOYSA-N	226591	US20260007684, Compound 73A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226591&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962746	336293692							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136932	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)F)c(F)c3)CC2)C1	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(18-24-26-27-25-18)10-13(8-11)23-16(29)19(5-6-19)12-2-3-15(14(20)9-12)30-17(21)22/h2-3,9,11,13,17H,4-8,10H2,1H3,(H,23,29)(H,24,25,26,27)	XBXUWWVJMGOGEZ-UHFFFAOYSA-N	226592	US20260007684, Compound 73B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226592&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962740	336293693							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136933	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(OC(F)F)c(F)c3)CC2)C1	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(18-24-26-27-25-18)10-13(8-11)23-16(29)19(5-6-19)12-2-3-15(14(20)9-12)30-17(21)22/h2-3,9,11,13,17H,4-8,10H2,1H3,(H,23,29)(H,24,25,26,27)	XBXUWWVJMGOGEZ-UHFFFAOYSA-N	226593	US20260007684, Compound 73C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226593&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962747	336293694							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136934	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(OC(F)F)c(F)c3)CC2)C1	InChI=1S/C19H23F3N6O2/c1-11-4-7-28(18-24-26-27-25-18)10-13(8-11)23-16(29)19(5-6-19)12-2-3-15(14(20)9-12)30-17(21)22/h2-3,9,11,13,17H,4-8,10H2,1H3,(H,23,29)(H,24,25,26,27)	XBXUWWVJMGOGEZ-UHFFFAOYSA-N	226594	US20260007684, Compound 73D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226594&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962748	336293695							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136935	Cc1ccc(C2(C(=O)N[C@@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1F	InChI=1S/C19H25FN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-4-3-12(2)15(20)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	WIDBXQYOPZWUPL-UHFFFAOYSA-N	226595	US20260007684, Compound 74A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226595&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962749	336293696							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136936	Cc1ccc(C2(C(=O)N[C@H]3C[C@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1F	InChI=1S/C19H25FN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-4-3-12(2)15(20)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	WIDBXQYOPZWUPL-UHFFFAOYSA-N	226596	US20260007684, Compound 74B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226596&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962750	336293697							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136937	Cc1ccc(C2(C(=O)N[C@@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1F	InChI=1S/C19H25FN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-4-3-12(2)15(20)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	WIDBXQYOPZWUPL-UHFFFAOYSA-N	226597	US20260007684, Compound 74C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226597&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962751	336293698							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136938	Cc1ccc(C2(C(=O)N[C@H]3C[C@@H](C)CCN(c4nnn[nH]4)C3)CC2)c(O)c1F	InChI=1S/C19H25FN6O2/c1-11-5-8-26(18-22-24-25-23-18)10-13(9-11)21-17(28)19(6-7-19)14-4-3-12(2)15(20)16(14)27/h3-4,11,13,27H,5-10H2,1-2H3,(H,21,28)(H,22,23,24,25)	WIDBXQYOPZWUPL-UHFFFAOYSA-N	226598	US20260007684, Compound 74D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226598&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962752	336293699							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136939	O=C(N[C@H]1CC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C18H21ClN6O2/c19-10-1-4-12(15(26)9-10)18(7-8-18)16(27)20-13-5-2-11-3-6-14(13)25(11)17-21-23-24-22-17/h1,4,9,11,13-14,26H,2-3,5-8H2,(H,20,27)(H,21,22,23,24)	DQBXCBQSPDHONF-UHFFFAOYSA-N	226599	US20260007684, Compound 75B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226599&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962753	336293700							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136940	O=C(N[C@@H]1CC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C18H21ClN6O2/c19-10-1-4-12(15(26)9-10)18(7-8-18)16(27)20-13-5-2-11-3-6-14(13)25(11)17-21-23-24-22-17/h1,4,9,11,13-14,26H,2-3,5-8H2,(H,20,27)(H,21,22,23,24)	DQBXCBQSPDHONF-UHFFFAOYSA-N	226600	US20260007684, Compound 75C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226600&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962754	336293701							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136941	O=C(N[C@H]1CC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)c(F)c2O)CC1	InChI=1S/C18H20ClFN6O2/c19-11-4-3-10(15(27)14(11)20)18(7-8-18)16(28)21-12-5-1-9-2-6-13(12)26(9)17-22-24-25-23-17/h3-4,9,12-13,27H,1-2,5-8H2,(H,21,28)(H,22,23,24,25)	IPDSNDNDNMVNNA-UHFFFAOYSA-N	226601	US20260007684, Compound 76B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226601&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962755	336293702							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136942	O=C(N[C@@H]1CC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)c(F)c2O)CC1	InChI=1S/C18H20ClFN6O2/c19-11-4-3-10(15(27)14(11)20)18(7-8-18)16(28)21-12-5-1-9-2-6-13(12)26(9)17-22-24-25-23-17/h3-4,9,12-13,27H,1-2,5-8H2,(H,21,28)(H,22,23,24,25)	IPDSNDNDNMVNNA-UHFFFAOYSA-N	226602	US20260007684, Compound 76C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226602&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962756	336293703							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136943	O=C(N[C@H]1CC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(OC(F)F)cc2O)CC1	InChI=1S/C19H22F2N6O3/c20-17(21)30-11-3-4-12(15(28)9-11)19(7-8-19)16(29)22-13-5-1-10-2-6-14(13)27(10)18-23-25-26-24-18/h3-4,9-10,13-14,17,28H,1-2,5-8H2,(H,22,29)(H,23,24,25,26)	IDZNCVWNOKQNET-UHFFFAOYSA-N	226603	US20260007684, Compound 77B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226603&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962757	336293704							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136944	O=C(N[C@@H]1CC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(OC(F)F)cc2O)CC1	InChI=1S/C19H22F2N6O3/c20-17(21)30-11-3-4-12(15(28)9-11)19(7-8-19)16(29)22-13-5-1-10-2-6-14(13)27(10)18-23-25-26-24-18/h3-4,9-10,13-14,17,28H,1-2,5-8H2,(H,22,29)(H,23,24,25,26)	IDZNCVWNOKQNET-UHFFFAOYSA-N	226604	US20260007684, Compound 77C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226604&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962758	336293705							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136945	O=C(N[C@H]1CC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(OC(F)(F)F)cc2O)CC1	InChI=1S/C19H21F3N6O3/c20-19(21,22)31-11-3-4-12(15(29)9-11)18(7-8-18)16(30)23-13-5-1-10-2-6-14(13)28(10)17-24-26-27-25-17/h3-4,9-10,13-14,29H,1-2,5-8H2,(H,23,30)(H,24,25,26,27)	DLSSTEBGPPTODD-UHFFFAOYSA-N	226605	US20260007684, Compound 78B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226605&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962759	336293706							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136946	O=C(N[C@@H]1CC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(OC(F)(F)F)cc2O)CC1	InChI=1S/C19H21F3N6O3/c20-19(21,22)31-11-3-4-12(15(29)9-11)18(7-8-18)16(30)23-13-5-1-10-2-6-14(13)28(10)17-24-26-27-25-17/h3-4,9-10,13-14,29H,1-2,5-8H2,(H,23,30)(H,24,25,26,27)	DLSSTEBGPPTODD-UHFFFAOYSA-N	226606	US20260007684, Compound 78C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226606&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962760	336293707							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136947	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O/c1-11-10-14(16-7-6-15(11)29(16)18-25-27-28-26-18)24-17(30)19(8-9-19)12-2-4-13(5-3-12)20(21,22)23/h2-5,11,14-16H,6-10H2,1H3,(H,24,30)(H,25,26,27,28)	DUZRRWHTXIBAFE-UHFFFAOYSA-N	226607	US20260007684, Compound 79A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226607&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962761	336293708							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136948	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O/c1-11-10-14(16-7-6-15(11)29(16)18-25-27-28-26-18)24-17(30)19(8-9-19)12-2-4-13(5-3-12)20(21,22)23/h2-5,11,14-16H,6-10H2,1H3,(H,24,30)(H,25,26,27,28)	DUZRRWHTXIBAFE-UHFFFAOYSA-N	226608	US20260007684, Compound 79B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226608&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962761	336293709							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136949	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O/c1-11-10-14(16-7-6-15(11)29(16)18-25-27-28-26-18)24-17(30)19(8-9-19)12-2-4-13(5-3-12)20(21,22)23/h2-5,11,14-16H,6-10H2,1H3,(H,24,30)(H,25,26,27,28)	DUZRRWHTXIBAFE-UHFFFAOYSA-N	226609	US20260007684, Compound 79C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226609&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962762	336293710							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136950	C[C@H]1C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O/c1-11-10-14(16-7-6-15(11)29(16)18-25-27-28-26-18)24-17(30)19(8-9-19)12-2-4-13(5-3-12)20(21,22)23/h2-5,11,14-16H,6-10H2,1H3,(H,24,30)(H,25,26,27,28)	DUZRRWHTXIBAFE-UHFFFAOYSA-N	226610	US20260007684, Compound 79D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226610&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962763	336293711							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136951	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C19H23ClN6O/c1-11-10-14(16-7-6-15(11)26(16)18-22-24-25-23-18)21-17(27)19(8-9-19)12-2-4-13(20)5-3-12/h2-5,11,14-16H,6-10H2,1H3,(H,21,27)(H,22,23,24,25)	UIIUHHNJWKPSEL-UHFFFAOYSA-N	226611	1-(4-chlorophenyl)-N-((1R,2R,4R,5S)-4- methyl-8-(1H-tetrazol-5-yl)-8- azabicyclo[3.2.1]octan-2-yl)cyclopropane- 1-carboxamide::US20260007684, Compound 80A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226611&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962764	336293712							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136952	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C19H23ClN6O/c1-11-10-14(16-7-6-15(11)26(16)18-22-24-25-23-18)21-17(27)19(8-9-19)12-2-4-13(20)5-3-12/h2-5,11,14-16H,6-10H2,1H3,(H,21,27)(H,22,23,24,25)	UIIUHHNJWKPSEL-UHFFFAOYSA-N	226612	US20260007684, Compound 80B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226612&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962765	336293713							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136953	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C19H23ClN6O/c1-11-10-14(16-7-6-15(11)26(16)18-22-24-25-23-18)21-17(27)19(8-9-19)12-2-4-13(20)5-3-12/h2-5,11,14-16H,6-10H2,1H3,(H,21,27)(H,22,23,24,25)	UIIUHHNJWKPSEL-UHFFFAOYSA-N	226613	US20260007684, Compound 80C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226613&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962766	336293714							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136954	C[C@H]1C[C@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C19H23ClN6O/c1-11-10-14(16-7-6-15(11)26(16)18-22-24-25-23-18)21-17(27)19(8-9-19)12-2-4-13(20)5-3-12/h2-5,11,14-16H,6-10H2,1H3,(H,21,27)(H,22,23,24,25)	UIIUHHNJWKPSEL-UHFFFAOYSA-N	226614	US20260007684, Compound 80D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226614&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962767	336293715							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136955	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(C4CC4)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C22H28N6O/c1-13-12-17(19-9-8-18(13)28(19)21-24-26-27-25-21)23-20(29)22(10-11-22)16-6-4-15(5-7-16)14-2-3-14/h4-7,13-14,17-19H,2-3,8-12H2,1H3,(H,23,29)(H,24,25,26,27)	GMWHJFDEYJAQFA-UHFFFAOYSA-N	226615	US20260007684, Compound 81A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226615&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962768	336293716							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136956	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(C4CC4)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C22H28N6O/c1-13-12-17(19-9-8-18(13)28(19)21-24-26-27-25-21)23-20(29)22(10-11-22)16-6-4-15(5-7-16)14-2-3-14/h4-7,13-14,17-19H,2-3,8-12H2,1H3,(H,23,29)(H,24,25,26,27)	GMWHJFDEYJAQFA-UHFFFAOYSA-N	226616	US20260007684, Compound 81B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226616&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962769	336293717							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136957	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C4CC4)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C22H28N6O/c1-13-12-17(19-9-8-18(13)28(19)21-24-26-27-25-21)23-20(29)22(10-11-22)16-6-4-15(5-7-16)14-2-3-14/h4-7,13-14,17-19H,2-3,8-12H2,1H3,(H,23,29)(H,24,25,26,27)	GMWHJFDEYJAQFA-UHFFFAOYSA-N	226617	US20260007684, Compound 81C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226617&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962770	336293718							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136958	C[C@H]1C[C@H](NC(=O)C2(c3ccc(C4CC4)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C22H28N6O/c1-13-12-17(19-9-8-18(13)28(19)21-24-26-27-25-21)23-20(29)22(10-11-22)16-6-4-15(5-7-16)14-2-3-14/h4-7,13-14,17-19H,2-3,8-12H2,1H3,(H,23,29)(H,24,25,26,27)	GMWHJFDEYJAQFA-UHFFFAOYSA-N	226618	US20260007684, Compound 81D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226618&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962771	336293719							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136959	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O2/c1-11-10-14(16-7-6-15(11)29(16)18-25-27-28-26-18)24-17(30)19(8-9-19)12-2-4-13(5-3-12)31-20(21,22)23/h2-5,11,14-16H,6-10H2,1H3,(H,24,30)(H,25,26,27,28)	XJQVTSYXLJBLLC-UHFFFAOYSA-N	226619	US20260007684, Compound 82A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226619&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962772	336293720							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136960	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O2/c1-11-10-14(16-7-6-15(11)29(16)18-25-27-28-26-18)24-17(30)19(8-9-19)12-2-4-13(5-3-12)31-20(21,22)23/h2-5,11,14-16H,6-10H2,1H3,(H,24,30)(H,25,26,27,28)	XJQVTSYXLJBLLC-UHFFFAOYSA-N	226620	US20260007684, Compound 82B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226620&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962773	336293721							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136961	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O2/c1-11-10-14(16-7-6-15(11)29(16)18-25-27-28-26-18)24-17(30)19(8-9-19)12-2-4-13(5-3-12)31-20(21,22)23/h2-5,11,14-16H,6-10H2,1H3,(H,24,30)(H,25,26,27,28)	XJQVTSYXLJBLLC-UHFFFAOYSA-N	226621	US20260007684, Compound 82C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226621&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962773	336293722							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136962	C[C@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O2/c1-11-10-14(16-7-6-15(11)29(16)18-25-27-28-26-18)24-17(30)19(8-9-19)12-2-4-13(5-3-12)31-20(21,22)23/h2-5,11,14-16H,6-10H2,1H3,(H,24,30)(H,25,26,27,28)	XJQVTSYXLJBLLC-UHFFFAOYSA-N	226622	US20260007684, Compound 82D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226622&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962774	336293723							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136963	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(C4CC4)c(F)c3O)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C22H27FN6O2/c1-11-10-15(17-7-6-16(11)29(17)21-25-27-28-26-21)24-20(31)22(8-9-22)14-5-4-13(12-2-3-12)18(23)19(14)30/h4-5,11-12,15-17,30H,2-3,6-10H2,1H3,(H,24,31)(H,25,26,27,28)	ALRYMFZXMZGSCN-UHFFFAOYSA-N	226623	US20260007684, Compound 83A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226623&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962775	336293724							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136964	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(C4CC4)c(F)c3O)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C22H27FN6O2/c1-11-10-15(17-7-6-16(11)29(17)21-25-27-28-26-21)24-20(31)22(8-9-22)14-5-4-13(12-2-3-12)18(23)19(14)30/h4-5,11-12,15-17,30H,2-3,6-10H2,1H3,(H,24,31)(H,25,26,27,28)	ALRYMFZXMZGSCN-UHFFFAOYSA-N	226624	US20260007684, Compound 83B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226624&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962776	336293725							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136965	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C4CC4)c(F)c3O)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C22H27FN6O2/c1-11-10-15(17-7-6-16(11)29(17)21-25-27-28-26-21)24-20(31)22(8-9-22)14-5-4-13(12-2-3-12)18(23)19(14)30/h4-5,11-12,15-17,30H,2-3,6-10H2,1H3,(H,24,31)(H,25,26,27,28)	ALRYMFZXMZGSCN-UHFFFAOYSA-N	226625	US20260007684, Compound 83C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226625&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962777	336293726							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136966	C[C@H]1C[C@H](NC(=O)C2(c3ccc(C4CC4)c(F)c3O)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C22H27FN6O2/c1-11-10-15(17-7-6-16(11)29(17)21-25-27-28-26-21)24-20(31)22(8-9-22)14-5-4-13(12-2-3-12)18(23)19(14)30/h4-5,11-12,15-17,30H,2-3,6-10H2,1H3,(H,24,31)(H,25,26,27,28)	ALRYMFZXMZGSCN-UHFFFAOYSA-N	226626	US20260007684, Compound 83D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226626&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962778	336293727							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136967	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3F)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H22F4N6O/c1-10-8-14(16-5-4-15(10)30(16)18-26-28-29-27-18)25-17(31)19(6-7-19)12-3-2-11(9-13(12)21)20(22,23)24/h2-3,9-10,14-16H,4-8H2,1H3,(H,25,31)(H,26,27,28,29)	IWFQUXJZDYCHLF-UHFFFAOYSA-N	226627	US20260007684, Compound 84A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226627&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962779	336293728							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136968	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3F)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H22F4N6O/c1-10-8-14(16-5-4-15(10)30(16)18-26-28-29-27-18)25-17(31)19(6-7-19)12-3-2-11(9-13(12)21)20(22,23)24/h2-3,9-10,14-16H,4-8H2,1H3,(H,25,31)(H,26,27,28,29)	IWFQUXJZDYCHLF-UHFFFAOYSA-N	226628	US20260007684, Compound 84B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226628&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962780	336293729							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136969	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3F)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H22F4N6O/c1-10-8-14(16-5-4-15(10)30(16)18-26-28-29-27-18)25-17(31)19(6-7-19)12-3-2-11(9-13(12)21)20(22,23)24/h2-3,9-10,14-16H,4-8H2,1H3,(H,25,31)(H,26,27,28,29)	IWFQUXJZDYCHLF-UHFFFAOYSA-N	226629	US20260007684, Compound 84C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226629&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962781	336293730							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136970	C[C@H]1C[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3F)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H22F4N6O/c1-10-8-14(16-5-4-15(10)30(16)18-26-28-29-27-18)25-17(31)19(6-7-19)12-3-2-11(9-13(12)21)20(22,23)24/h2-3,9-10,14-16H,4-8H2,1H3,(H,25,31)(H,26,27,28,29)	IWFQUXJZDYCHLF-UHFFFAOYSA-N	226630	US20260007684, Compound 84D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226630&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962782	336293731							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136971	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(SC(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6OS/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	XIFRABLLLGUJSZ-UHFFFAOYSA-N	226631	US20260007684, Compound 85A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226631&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962783	336293732							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136972	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(SC(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6OS/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	XIFRABLLLGUJSZ-UHFFFAOYSA-N	226632	US20260007684, Compound 85B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226632&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962784	336293733							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136973	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(SC(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6OS/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	XIFRABLLLGUJSZ-UHFFFAOYSA-N	226633	US20260007684, Compound 85C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226633&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962785	336293734							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136974	C[C@H]1C[C@H](NC(=O)C2(c3ccc(SC(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6OS/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-17(29)20(8-9-20)12-2-4-13(5-3-12)30-18(21)22/h2-5,11,14-16,18H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	XIFRABLLLGUJSZ-UHFFFAOYSA-N	226634	US20260007684, Compound 85D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226634&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962786	336293735							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136975	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-18(29)20(8-9-20)13-4-2-12(3-5-13)17(21)22/h2-5,11,14-17H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	GDQGLENCWLOKPY-UHFFFAOYSA-N	226635	US20260007684, Compound 86A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226635&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962787	336293736							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136976	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(C(F)F)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-18(29)20(8-9-20)13-4-2-12(3-5-13)17(21)22/h2-5,11,14-17H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	GDQGLENCWLOKPY-UHFFFAOYSA-N	226636	US20260007684, Compound 86B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226636&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962788	336293737							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136977	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-18(29)20(8-9-20)13-4-2-12(3-5-13)17(21)22/h2-5,11,14-17H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	GDQGLENCWLOKPY-UHFFFAOYSA-N	226637	US20260007684, Compound 86C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226637&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962789	336293738							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136978	C[C@H]1C[C@H](NC(=O)C2(c3ccc(C(F)F)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H24F2N6O/c1-11-10-14(16-7-6-15(11)28(16)19-24-26-27-25-19)23-18(29)20(8-9-20)13-4-2-12(3-5-13)17(21)22/h2-5,11,14-17H,6-10H2,1H3,(H,23,29)(H,24,25,26,27)	GDQGLENCWLOKPY-UHFFFAOYSA-N	226638	US20260007684, Compound 86D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226638&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962790	336293739							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136979	Cc1ccc(C2(C(=O)N[C@@H]3C[C@@H](C)[C@@H]4CC[C@H]3N4c3nnn[nH]3)CC2)cc1	InChI=1S/C20H26N6O/c1-12-3-5-14(6-4-12)20(9-10-20)18(27)21-15-11-13(2)16-7-8-17(15)26(16)19-22-24-25-23-19/h3-6,13,15-17H,7-11H2,1-2H3,(H,21,27)(H,22,23,24,25)	HDIQNQXMBNVYGU-UHFFFAOYSA-N	226639	US20260007684, Compound 87A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226639&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962791	336293740							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136980	Cc1ccc(C2(C(=O)N[C@H]3C[C@@H](C)[C@@H]4CC[C@H]3N4c3nnn[nH]3)CC2)cc1	InChI=1S/C20H26N6O/c1-12-3-5-14(6-4-12)20(9-10-20)18(27)21-15-11-13(2)16-7-8-17(15)26(16)19-22-24-25-23-19/h3-6,13,15-17H,7-11H2,1-2H3,(H,21,27)(H,22,23,24,25)	HDIQNQXMBNVYGU-UHFFFAOYSA-N	226640	US20260007684, Compound 87B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226640&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962792	336293741							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136981	Cc1ccc(C2(C(=O)N[C@@H]3C[C@H](C)[C@H]4CC[C@@H]3N4c3nnn[nH]3)CC2)cc1	InChI=1S/C20H26N6O/c1-12-3-5-14(6-4-12)20(9-10-20)18(27)21-15-11-13(2)16-7-8-17(15)26(16)19-22-24-25-23-19/h3-6,13,15-17H,7-11H2,1-2H3,(H,21,27)(H,22,23,24,25)	HDIQNQXMBNVYGU-UHFFFAOYSA-N	226641	US20260007684, Compound 87C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226641&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962793	336293742							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136982	Cc1ccc(C2(C(=O)N[C@H]3C[C@H](C)[C@H]4CC[C@@H]3N4c3nnn[nH]3)CC2)cc1	InChI=1S/C20H26N6O/c1-12-3-5-14(6-4-12)20(9-10-20)18(27)21-15-11-13(2)16-7-8-17(15)26(16)19-22-24-25-23-19/h3-6,13,15-17H,7-11H2,1-2H3,(H,21,27)(H,22,23,24,25)	HDIQNQXMBNVYGU-UHFFFAOYSA-N	226642	US20260007684, Compound 87D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226642&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962794	336293743							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136983	O=C(N[C@@H]1CCC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(C(F)(F)F)cc2O)CC1	InChI=1S/C20H23F3N6O2/c21-20(22,23)11-4-6-13(16(30)10-11)19(8-9-19)17(31)24-14-3-1-2-12-5-7-15(14)29(12)18-25-27-28-26-18/h4,6,10,12,14-15,30H,1-3,5,7-9H2,(H,24,31)(H,25,26,27,28)	MNTKUKDSNCYXBL-UHFFFAOYSA-N	226643	US20260007684, Compound 88A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226643&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962795	336293744							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136984	O=C(N[C@H]1CCC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(C(F)(F)F)cc2O)CC1	InChI=1S/C20H23F3N6O2/c21-20(22,23)11-4-6-13(16(30)10-11)19(8-9-19)17(31)24-14-3-1-2-12-5-7-15(14)29(12)18-25-27-28-26-18/h4,6,10,12,14-15,30H,1-3,5,7-9H2,(H,24,31)(H,25,26,27,28)	MNTKUKDSNCYXBL-UHFFFAOYSA-N	226644	US20260007684, Compound 88B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226644&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962796	336293745							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136985	O=C(N[C@@H]1CCC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(C(F)(F)F)cc2O)CC1	InChI=1S/C20H23F3N6O2/c21-20(22,23)11-4-6-13(16(30)10-11)19(8-9-19)17(31)24-14-3-1-2-12-5-7-15(14)29(12)18-25-27-28-26-18/h4,6,10,12,14-15,30H,1-3,5,7-9H2,(H,24,31)(H,25,26,27,28)	MNTKUKDSNCYXBL-UHFFFAOYSA-N	226645	US20260007684, Compound 88C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226645&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962797	336293746							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136986	O=C(N[C@H]1CCC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(C(F)(F)F)cc2O)CC1	InChI=1S/C20H23F3N6O2/c21-20(22,23)11-4-6-13(16(30)10-11)19(8-9-19)17(31)24-14-3-1-2-12-5-7-15(14)29(12)18-25-27-28-26-18/h4,6,10,12,14-15,30H,1-3,5,7-9H2,(H,24,31)(H,25,26,27,28)	MNTKUKDSNCYXBL-UHFFFAOYSA-N	226646	US20260007684, Compound 88D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226646&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962798	336293747							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136987	C[C@H]1CC[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C19H23F3N6O2/c1-11-2-4-13(10-28(9-11)17-24-26-27-25-17)23-16(30)18(6-7-18)14-5-3-12(8-15(14)29)19(20,21)22/h3,5,8,11,13,29H,2,4,6-7,9-10H2,1H3,(H,23,30)(H,24,25,26,27)	NGTWYJKEMDSDAX-UHFFFAOYSA-N	226647	US20260007684, Compound 89A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226647&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962799	336293748							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136988	C[C@H]1CC[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C19H23F3N6O2/c1-11-2-4-13(10-28(9-11)17-24-26-27-25-17)23-16(30)18(6-7-18)14-5-3-12(8-15(14)29)19(20,21)22/h3,5,8,11,13,29H,2,4,6-7,9-10H2,1H3,(H,23,30)(H,24,25,26,27)	NGTWYJKEMDSDAX-UHFFFAOYSA-N	226648	US20260007684, Compound 89B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226648&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962800	336293749							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136989	C[C@@H]1CC[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C19H23F3N6O2/c1-11-2-4-13(10-28(9-11)17-24-26-27-25-17)23-16(30)18(6-7-18)14-5-3-12(8-15(14)29)19(20,21)22/h3,5,8,11,13,29H,2,4,6-7,9-10H2,1H3,(H,23,30)(H,24,25,26,27)	NGTWYJKEMDSDAX-UHFFFAOYSA-N	226649	US20260007684, Compound 89C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226649&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962801	336293750							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136990	C[C@@H]1CC[C@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C19H23F3N6O2/c1-11-2-4-13(10-28(9-11)17-24-26-27-25-17)23-16(30)18(6-7-18)14-5-3-12(8-15(14)29)19(20,21)22/h3,5,8,11,13,29H,2,4,6-7,9-10H2,1H3,(H,23,30)(H,24,25,26,27)	NGTWYJKEMDSDAX-UHFFFAOYSA-N	226650	US20260007684, Compound 89D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226650&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962802	336293751							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136991	C[C@H]1CC[C@@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O2/c1-11-2-4-13(10-25(9-11)17-21-23-24-22-17)20-16(27)18(6-7-18)14-5-3-12(19)8-15(14)26/h3,5,8,11,13,26H,2,4,6-7,9-10H2,1H3,(H,20,27)(H,21,22,23,24)	ZUXQIJRAYINWRK-UHFFFAOYSA-N	226651	US20260007684, Compound 90A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226651&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962803	336293752							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136992	C[C@H]1CC[C@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O2/c1-11-2-4-13(10-25(9-11)17-21-23-24-22-17)20-16(27)18(6-7-18)14-5-3-12(19)8-15(14)26/h3,5,8,11,13,26H,2,4,6-7,9-10H2,1H3,(H,20,27)(H,21,22,23,24)	ZUXQIJRAYINWRK-UHFFFAOYSA-N	226652	US20260007684, Compound 90B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226652&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962804	336293753							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136993	C[C@@H]1CC[C@@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O2/c1-11-2-4-13(10-25(9-11)17-21-23-24-22-17)20-16(27)18(6-7-18)14-5-3-12(19)8-15(14)26/h3,5,8,11,13,26H,2,4,6-7,9-10H2,1H3,(H,20,27)(H,21,22,23,24)	ZUXQIJRAYINWRK-UHFFFAOYSA-N	226653	US20260007684, Compound 90C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226653&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962805	336293754							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136994	C[C@@H]1CC[C@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O2/c1-11-2-4-13(10-25(9-11)17-21-23-24-22-17)20-16(27)18(6-7-18)14-5-3-12(19)8-15(14)26/h3,5,8,11,13,26H,2,4,6-7,9-10H2,1H3,(H,20,27)(H,21,22,23,24)	ZUXQIJRAYINWRK-UHFFFAOYSA-N	226654	US20260007684, Compound 90D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226654&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962806	336293755							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136995	C[C@H]1CC[C@@H](NC(=O)C2(c3ccc(C4CC4)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C21H28N6O2/c1-13-2-6-16(12-27(11-13)20-23-25-26-24-20)22-19(29)21(8-9-21)17-7-5-15(10-18(17)28)14-3-4-14/h5,7,10,13-14,16,28H,2-4,6,8-9,11-12H2,1H3,(H,22,29)(H,23,24,25,26)	VAESIDVTXNWKCW-UHFFFAOYSA-N	226655	US20260007684, Compound 91A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226655&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962807	336293756							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136996	C[C@H]1CC[C@H](NC(=O)C2(c3ccc(C4CC4)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C21H28N6O2/c1-13-2-6-16(12-27(11-13)20-23-25-26-24-20)22-19(29)21(8-9-21)17-7-5-15(10-18(17)28)14-3-4-14/h5,7,10,13-14,16,28H,2-4,6,8-9,11-12H2,1H3,(H,22,29)(H,23,24,25,26)	VAESIDVTXNWKCW-UHFFFAOYSA-N	226656	US20260007684, Compound 91B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226656&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962808	336293757							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136997	C[C@@H]1CC[C@@H](NC(=O)C2(c3ccc(C4CC4)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C21H28N6O2/c1-13-2-6-16(12-27(11-13)20-23-25-26-24-20)22-19(29)21(8-9-21)17-7-5-15(10-18(17)28)14-3-4-14/h5,7,10,13-14,16,28H,2-4,6,8-9,11-12H2,1H3,(H,22,29)(H,23,24,25,26)	VAESIDVTXNWKCW-UHFFFAOYSA-N	226657	US20260007684, Compound 91C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226657&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962809	336293758							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136998	C[C@@H]1CC[C@H](NC(=O)C2(c3ccc(C4CC4)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C21H28N6O2/c1-13-2-6-16(12-27(11-13)20-23-25-26-24-20)22-19(29)21(8-9-21)17-7-5-15(10-18(17)28)14-3-4-14/h5,7,10,13-14,16,28H,2-4,6,8-9,11-12H2,1H3,(H,22,29)(H,23,24,25,26)	VAESIDVTXNWKCW-UHFFFAOYSA-N	226658	US20260007684, Compound 91D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226658&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962810	336293759							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
136999	O=C(N[C@@H]1CCC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C19H23ClN6O2/c20-11-4-6-13(16(27)10-11)19(8-9-19)17(28)21-14-3-1-2-12-5-7-15(14)26(12)18-22-24-25-23-18/h4,6,10,12,14-15,27H,1-3,5,7-9H2,(H,21,28)(H,22,23,24,25)	IHFVYAKOOABESX-UHFFFAOYSA-N	226659	N-((1R,2R,6R)-9-(1H-tetrazol-5-yl)-9- azabicyclo[4.2.1]nonan-2-yl)-1-(4-chloro-2- hydroxyphenyl)cyclopropane-1- carboxamide::US20260007684, Compound 92A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226659&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962811	336293760							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
137000	O=C(N[C@H]1CCC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C19H23ClN6O2/c20-11-4-6-13(16(27)10-11)19(8-9-19)17(28)21-14-3-1-2-12-5-7-15(14)26(12)18-22-24-25-23-18/h4,6,10,12,14-15,27H,1-3,5,7-9H2,(H,21,28)(H,22,23,24,25)	IHFVYAKOOABESX-UHFFFAOYSA-N	226660	US20260007684, Compound 92B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226660&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962811	336293761							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
137001	O=C(N[C@@H]1CCC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C19H23ClN6O2/c20-11-4-6-13(16(27)10-11)19(8-9-19)17(28)21-14-3-1-2-12-5-7-15(14)26(12)18-22-24-25-23-18/h4,6,10,12,14-15,27H,1-3,5,7-9H2,(H,21,28)(H,22,23,24,25)	IHFVYAKOOABESX-UHFFFAOYSA-N	226661	US20260007684, Compound 92C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226661&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962812	336293762							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
137002	O=C(N[C@H]1CCC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C19H23ClN6O2/c20-11-4-6-13(16(27)10-11)19(8-9-19)17(28)21-14-3-1-2-12-5-7-15(14)26(12)18-22-24-25-23-18/h4,6,10,12,14-15,27H,1-3,5,7-9H2,(H,21,28)(H,22,23,24,25)	IHFVYAKOOABESX-UHFFFAOYSA-N	226662	US20260007684, Compound 92D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226662&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962813	336293763							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
137003	O=C(N[C@@H]1CCC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(C3CC3)cc2O)CC1	InChI=1S/C22H28N6O2/c29-19-12-14(13-4-5-13)6-8-16(19)22(10-11-22)20(30)23-17-3-1-2-15-7-9-18(17)28(15)21-24-26-27-25-21/h6,8,12-13,15,17-18,29H,1-5,7,9-11H2,(H,23,30)(H,24,25,26,27)	QLQUQZLGBJMZAS-UHFFFAOYSA-N	226663	US20260007684, Compound 93A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226663&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962814	336293764							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
137004	O=C(N[C@H]1CCC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(C3CC3)cc2O)CC1	InChI=1S/C22H28N6O2/c29-19-12-14(13-4-5-13)6-8-16(19)22(10-11-22)20(30)23-17-3-1-2-15-7-9-18(17)28(15)21-24-26-27-25-21/h6,8,12-13,15,17-18,29H,1-5,7,9-11H2,(H,23,30)(H,24,25,26,27)	QLQUQZLGBJMZAS-UHFFFAOYSA-N	226664	US20260007684, Compound 93B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226664&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962815	336293765							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
137708	O=C(N[C@@H]1CCC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(C3CC3)cc2O)CC1	InChI=1S/C22H28N6O2/c29-19-12-14(13-4-5-13)6-8-16(19)22(10-11-22)20(30)23-17-3-1-2-15-7-9-18(17)28(15)21-24-26-27-25-21/h6,8,12-13,15,17-18,29H,1-5,7,9-11H2,(H,23,30)(H,24,25,26,27)	QLQUQZLGBJMZAS-UHFFFAOYSA-N	226665	US20260007684, Compound 93C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226665&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962816	336293766							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143238	O=C(NC1CCC[C@H]2CC[C@@H]1N2c1nnn[nH]1)C1(c2ccc(C3CC3)cc2O)CC1	InChI=1S/C22H28N6O2/c29-19-12-14(13-4-5-13)6-8-16(19)22(10-11-22)20(30)23-17-3-1-2-15-7-9-18(17)28(15)21-24-26-27-25-21/h6,8,12-13,15,17-18,29H,1-5,7,9-11H2,(H,23,30)(H,24,25,26,27)	QLQUQZLGBJMZAS-UHFFFAOYSA-N	226666	US20260007684, Compound 93D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226666&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962817	336293767							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143239	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C4CC4(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C20H24F2N6O2/c1-11-6-13(10-28(9-11)18-24-26-27-25-18)23-17(30)19(4-5-19)14-3-2-12(7-16(14)29)15-8-20(15,21)22/h2-3,7,11,13,15,29H,4-6,8-10H2,1H3,(H,23,30)(H,24,25,26,27)	VDVDAUMZCYQTAB-UHFFFAOYSA-N	226667	US20260007684, Compound 94A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226667&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962818	336293768							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143240	Cc1cc(C2CC2)cc(O)c1C1(C(=O)N[C@@H]2C[C@H](C)CN(c3nnn[nH]3)C2)CC1	InChI=1S/C21H28N6O2/c1-12-7-16(11-27(10-12)20-23-25-26-24-20)22-19(29)21(5-6-21)18-13(2)8-15(9-17(18)28)14-3-4-14/h8-9,12,14,16,28H,3-7,10-11H2,1-2H3,(H,22,29)(H,23,24,25,26)	OBXGREVXGCBSBI-UHFFFAOYSA-N	226668	US20260007684, Compound 95A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226668&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962819	336293769							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143241	Cc1cc(C2CC2)cc(O)c1C1(C(=O)N[C@@H]2C[C@H](C)CN(c3nnn[nH]3)C2)CC1	InChI=1S/C21H28N6O2/c1-12-7-16(11-27(10-12)20-23-25-26-24-20)22-19(29)21(5-6-21)18-13(2)8-15(9-17(18)28)14-3-4-14/h8-9,12,14,16,28H,3-7,10-11H2,1-2H3,(H,22,29)(H,23,24,25,26)	OBXGREVXGCBSBI-UHFFFAOYSA-N	226669	US20260007684, Compound 96A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226669&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962820	336293770							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143242	C[C@H]1C[C@@H](NC(=O)C2(c3c(O)cc(C4CC4)cc3C(F)F)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C21H26F2N6O2/c1-11-6-14(10-29(9-11)20-25-27-28-26-20)24-19(31)21(4-5-21)17-15(18(22)23)7-13(8-16(17)30)12-2-3-12/h7-8,11-12,14,18,30H,2-6,9-10H2,1H3,(H,24,31)(H,25,26,27,28)	KWPSZVIKLKLDKC-UHFFFAOYSA-N	226670	US20260007684, Compound 97A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226670&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962821	336293771							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143243	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(C3=NCC(Cl)C=C3O)CC2)C1	InChI=1S/C17H24ClN7O2/c1-10-2-5-25(16-21-23-24-22-16)9-12(6-10)20-15(27)17(3-4-17)14-13(26)7-11(18)8-19-14/h7,10-12,26H,2-6,8-9H2,1H3,(H,20,27)(H,21,22,23,24)	QOQPJNLAICSZCS-UHFFFAOYSA-N	226671	US20260007684, Compound Rac-98A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226671&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962822	336293772							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143244	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(C3=NCC(Cl)C=C3O)CC2)C1	InChI=1S/C17H24ClN7O2/c1-10-2-5-25(16-21-23-24-22-16)9-12(6-10)20-15(27)17(3-4-17)14-13(26)7-11(18)8-19-14/h7,10-12,26H,2-6,8-9H2,1H3,(H,20,27)(H,21,22,23,24)	QOQPJNLAICSZCS-UHFFFAOYSA-N	226672	US20260007684, Compound Rac-98D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226672&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962823	336293773							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143245	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(C3=NCC(Cl)C=C3O)CC2)C1	InChI=1S/C17H24ClN7O2/c1-10-2-5-25(16-21-23-24-22-16)9-12(6-10)20-15(27)17(3-4-17)14-13(26)7-11(18)8-19-14/h7,10-12,26H,2-6,8-9H2,1H3,(H,20,27)(H,21,22,23,24)	QOQPJNLAICSZCS-UHFFFAOYSA-N	226673	US20260007684, Compound Rac-98B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226673&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962824	336293774							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143246	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(C3=NCC(Cl)C=C3O)CC2)C1	InChI=1S/C17H24ClN7O2/c1-10-2-5-25(16-21-23-24-22-16)9-12(6-10)20-15(27)17(3-4-17)14-13(26)7-11(18)8-19-14/h7,10-12,26H,2-6,8-9H2,1H3,(H,20,27)(H,21,22,23,24)	QOQPJNLAICSZCS-UHFFFAOYSA-N	226674	US20260007684, Compound Rac-98C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226674&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962825	336293775							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143247	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3cnc(Cl)cc3O)CC2)C1	InChI=1S/C17H22ClN7O2/c1-10-2-5-25(16-21-23-24-22-16)9-11(6-10)20-15(27)17(3-4-17)12-8-19-14(18)7-13(12)26/h7-8,10-11H,2-6,9H2,1H3,(H,19,26)(H,20,27)(H,21,22,23,24)	BLRXODNWOMUJDA-UHFFFAOYSA-N	226675	US20260007684, Compound 99A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226675&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962826	336293776							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143248	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3cnc(Cl)cc3O)CC2)C1	InChI=1S/C17H22ClN7O2/c1-10-2-5-25(16-21-23-24-22-16)9-11(6-10)20-15(27)17(3-4-17)12-8-19-14(18)7-13(12)26/h7-8,10-11H,2-6,9H2,1H3,(H,19,26)(H,20,27)(H,21,22,23,24)	BLRXODNWOMUJDA-UHFFFAOYSA-N	226676	US20260007684, Compound 99B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 5500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226676&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962827	336293777							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143249	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3cnc(Cl)cc3O)CC2)C1	InChI=1S/C17H22ClN7O2/c1-10-2-5-25(16-21-23-24-22-16)9-11(6-10)20-15(27)17(3-4-17)12-8-19-14(18)7-13(12)26/h7-8,10-11H,2-6,9H2,1H3,(H,19,26)(H,20,27)(H,21,22,23,24)	BLRXODNWOMUJDA-UHFFFAOYSA-N	226677	US20260007684, Compound 99C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226677&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962828	336293778							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143250	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3cnc(Cl)cc3O)CC2)C1	InChI=1S/C17H22ClN7O2/c1-10-2-5-25(16-21-23-24-22-16)9-11(6-10)20-15(27)17(3-4-17)12-8-19-14(18)7-13(12)26/h7-8,10-11H,2-6,9H2,1H3,(H,19,26)(H,20,27)(H,21,22,23,24)	BLRXODNWOMUJDA-UHFFFAOYSA-N	226678	US20260007684, Compound 99D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226678&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962829	336293779							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143251	C[C@@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)nc3O)CC2)C1	InChI=1S/C17H22ClN7O2/c1-10-4-7-25(16-21-23-24-22-16)9-11(8-10)19-15(27)17(5-6-17)12-2-3-13(18)20-14(12)26/h2-3,10-11H,4-9H2,1H3,(H,19,27)(H,20,26)(H,21,22,23,24)	OZJNOXZCCNVPBL-UHFFFAOYSA-N	226679	US20260007684, Compound 100A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226679&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962830	336293780							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143252	C[C@@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)nc3O)CC2)C1	InChI=1S/C17H22ClN7O2/c1-10-4-7-25(16-21-23-24-22-16)9-11(8-10)19-15(27)17(5-6-17)12-2-3-13(18)20-14(12)26/h2-3,10-11H,4-9H2,1H3,(H,19,27)(H,20,26)(H,21,22,23,24)	OZJNOXZCCNVPBL-UHFFFAOYSA-N	226680	US20260007684, Compound 100B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226680&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962831	336293781							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143253	C[C@H]1CCN(c2nnn[nH]2)C[C@H](NC(=O)C2(c3ccc(Cl)nc3O)CC2)C1	InChI=1S/C17H22ClN7O2/c1-10-4-7-25(16-21-23-24-22-16)9-11(8-10)19-15(27)17(5-6-17)12-2-3-13(18)20-14(12)26/h2-3,10-11H,4-9H2,1H3,(H,19,27)(H,20,26)(H,21,22,23,24)	OZJNOXZCCNVPBL-UHFFFAOYSA-N	226681	US20260007684, Compound 100C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226681&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962832	336293782							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143254	C[C@H]1CCN(c2nnn[nH]2)C[C@@H](NC(=O)C2(c3ccc(Cl)nc3O)CC2)C1	InChI=1S/C17H22ClN7O2/c1-10-4-7-25(16-21-23-24-22-16)9-11(8-10)19-15(27)17(5-6-17)12-2-3-13(18)20-14(12)26/h2-3,10-11H,4-9H2,1H3,(H,19,27)(H,20,26)(H,21,22,23,24)	OZJNOXZCCNVPBL-UHFFFAOYSA-N	226682	US20260007684, Compound 100D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226682&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962833	336293783							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143255	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3F)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O2/c1-10-8-14(16-5-4-15(10)29(16)19-25-27-28-26-19)24-17(30)20(6-7-20)12-3-2-11(9-13(12)21)31-18(22)23/h2-3,9-10,14-16,18H,4-8H2,1H3,(H,24,30)(H,25,26,27,28)	PMUWTHQDCSLMOO-UHFFFAOYSA-N	226683	US20260007684, Compound 101A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226683&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962834	336293784							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143256	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3F)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O2/c1-10-8-14(16-5-4-15(10)29(16)19-25-27-28-26-19)24-17(30)20(6-7-20)12-3-2-11(9-13(12)21)31-18(22)23/h2-3,9-10,14-16,18H,4-8H2,1H3,(H,24,30)(H,25,26,27,28)	PMUWTHQDCSLMOO-UHFFFAOYSA-N	226684	US20260007684, Compound 101B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226684&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962835	336293785							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143257	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)F)cc3F)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O2/c1-10-8-14(16-5-4-15(10)29(16)19-25-27-28-26-19)24-17(30)20(6-7-20)12-3-2-11(9-13(12)21)31-18(22)23/h2-3,9-10,14-16,18H,4-8H2,1H3,(H,24,30)(H,25,26,27,28)	PMUWTHQDCSLMOO-UHFFFAOYSA-N	226685	US20260007684, Compound 101C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226685&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962836	336293786							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143258	C[C@H]1C[C@H](NC(=O)C2(c3ccc(OC(F)F)cc3F)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C20H23F3N6O2/c1-10-8-14(16-5-4-15(10)29(16)19-25-27-28-26-19)24-17(30)20(6-7-20)12-3-2-11(9-13(12)21)31-18(22)23/h2-3,9-10,14-16,18H,4-8H2,1H3,(H,24,30)(H,25,26,27,28)	PMUWTHQDCSLMOO-UHFFFAOYSA-N	226686	US20260007684, Compound 101D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226686&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962837	336293787							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143259	COc1cc(F)c(C2(C(=O)N[C@@H]3C[C@@H](C)[C@@H]4CC[C@H]3N4c3nnn[nH]3)CC2)c(F)c1	InChI=1S/C20H24F2N6O2/c1-10-7-14(16-4-3-15(10)28(16)19-24-26-27-25-19)23-18(29)20(5-6-20)17-12(21)8-11(30-2)9-13(17)22/h8-10,14-16H,3-7H2,1-2H3,(H,23,29)(H,24,25,26,27)	UDTPHERBOJGOTN-UHFFFAOYSA-N	226687	US20260007684, Compound 102A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226687&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962838	336293788							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143260	COc1cc(F)c(C2(C(=O)N[C@H]3C[C@H](C)[C@H]4CC[C@@H]3N4c3nnn[nH]3)CC2)c(F)c1	InChI=1S/C20H24F2N6O2/c1-10-7-14(16-4-3-15(10)28(16)19-24-26-27-25-19)23-18(29)20(5-6-20)17-12(21)8-11(30-2)9-13(17)22/h8-10,14-16H,3-7H2,1-2H3,(H,23,29)(H,24,25,26,27)	UDTPHERBOJGOTN-UHFFFAOYSA-N	226688	US20260007684, Compound 102D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226688&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962839	336293789							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143261	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C19H23ClN6O/c1-11-10-14(16-7-6-15(11)26(16)18-22-24-25-23-18)21-17(27)19(8-9-19)12-2-4-13(20)5-3-12/h2-5,11,14-16H,6-10H2,1H3,(H,21,27)(H,22,23,24,25)	UIIUHHNJWKPSEL-UHFFFAOYSA-N	226689	US20260007684, Compound 103A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226689&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962840	336293790							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143262	C[C@@H]1C[C@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C19H23ClN6O/c1-11-10-14(16-7-6-15(11)26(16)18-22-24-25-23-18)21-17(27)19(8-9-19)12-2-4-13(20)5-3-12/h2-5,11,14-16H,6-10H2,1H3,(H,21,27)(H,22,23,24,25)	UIIUHHNJWKPSEL-UHFFFAOYSA-N	226690	US20260007684, Compound 103B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226690&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962841	336293791							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143263	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C19H23ClN6O/c1-11-10-14(16-7-6-15(11)26(16)18-22-24-25-23-18)21-17(27)19(8-9-19)12-2-4-13(20)5-3-12/h2-5,11,14-16H,6-10H2,1H3,(H,21,27)(H,22,23,24,25)	UIIUHHNJWKPSEL-UHFFFAOYSA-N	226691	US20260007684, Compound 103C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 75000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226691&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962842	336293792							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143264	C[C@H]1C[C@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)[C@@H]2CC[C@H]1N2c1nnn[nH]1	InChI=1S/C19H23ClN6O/c1-11-10-14(16-7-6-15(11)26(16)18-22-24-25-23-18)21-17(27)19(8-9-19)12-2-4-13(20)5-3-12/h2-5,11,14-16H,6-10H2,1H3,(H,21,27)(H,22,23,24,25)	UIIUHHNJWKPSEL-UHFFFAOYSA-N	226692	US20260007684, Compound 103D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226692&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962843	336293793							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143265	C[C@H]1C[C@@H]2CC[C@H]([C@H](NC(=O)C3(c4ccc(C(F)(F)F)cc4)CC3)C1)N2c1nnn[nH]1	InChI=1S/C21H25F3N6O/c1-12-10-15-6-7-17(30(15)19-26-28-29-27-19)16(11-12)25-18(31)20(8-9-20)13-2-4-14(5-3-13)21(22,23)24/h2-5,12,15-17H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	QKUSVBPEEVPWJS-UHFFFAOYSA-N	226693	US20260007684, Compound 104A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226693&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962844	336293794							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143266	C[C@H]1C[C@@H]2CC[C@H]([C@@H](NC(=O)C3(c4ccc(C(F)(F)F)cc4)CC3)C1)N2c1nnn[nH]1	InChI=1S/C21H25F3N6O/c1-12-10-15-6-7-17(30(15)19-26-28-29-27-19)16(11-12)25-18(31)20(8-9-20)13-2-4-14(5-3-13)21(22,23)24/h2-5,12,15-17H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	QKUSVBPEEVPWJS-UHFFFAOYSA-N	226694	US20260007684, Compound 104B	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226694&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962845	336293795							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143267	C[C@@H]1C[C@H]2CC[C@@H]([C@H](NC(=O)C3(c4ccc(C(F)(F)F)cc4)CC3)C1)N2c1nnn[nH]1	InChI=1S/C21H25F3N6O/c1-12-10-15-6-7-17(30(15)19-26-28-29-27-19)16(11-12)25-18(31)20(8-9-20)13-2-4-14(5-3-13)21(22,23)24/h2-5,12,15-17H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	QKUSVBPEEVPWJS-UHFFFAOYSA-N	226695	US20260007684, Compound 104C	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		<1000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226695&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962846	336293796							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143268	C[C@@H]1C[C@H]2CC[C@@H]([C@@H](NC(=O)C3(c4ccc(C(F)(F)F)cc4)CC3)C1)N2c1nnn[nH]1	InChI=1S/C21H25F3N6O/c1-12-10-15-6-7-17(30(15)19-26-28-29-27-19)16(11-12)25-18(31)20(8-9-20)13-2-4-14(5-3-13)21(22,23)24/h2-5,12,15-17H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	QKUSVBPEEVPWJS-UHFFFAOYSA-N	226696	US20260007684, Compound 104D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226696&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962847	336293797							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143269	C[C@@H]1C[C@@H]2CC[C@H]([C@H](NC(=O)C3(c4ccc(C(F)(F)F)cc4)CC3)C1)N2c1nnn[nH]1	InChI=1S/C21H25F3N6O/c1-12-10-15-6-7-17(30(15)19-26-28-29-27-19)16(11-12)25-18(31)20(8-9-20)13-2-4-14(5-3-13)21(22,23)24/h2-5,12,15-17H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	QKUSVBPEEVPWJS-UHFFFAOYSA-N	226697	US20260007684, Compound 104E	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226697&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962848	336293798							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143270	C[C@@H]1C[C@@H]2CC[C@H]([C@@H](NC(=O)C3(c4ccc(C(F)(F)F)cc4)CC3)C1)N2c1nnn[nH]1	InChI=1S/C21H25F3N6O/c1-12-10-15-6-7-17(30(15)19-26-28-29-27-19)16(11-12)25-18(31)20(8-9-20)13-2-4-14(5-3-13)21(22,23)24/h2-5,12,15-17H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	QKUSVBPEEVPWJS-UHFFFAOYSA-N	226698	US20260007684, Compound 104F	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 30000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226698&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962849	336293799							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143271	C[C@H]1C[C@H]2CC[C@@H]([C@H](NC(=O)C3(c4ccc(C(F)(F)F)cc4)CC3)C1)N2c1nnn[nH]1	InChI=1S/C21H25F3N6O/c1-12-10-15-6-7-17(30(15)19-26-28-29-27-19)16(11-12)25-18(31)20(8-9-20)13-2-4-14(5-3-13)21(22,23)24/h2-5,12,15-17H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	QKUSVBPEEVPWJS-UHFFFAOYSA-N	226699	US20260007684, Compound 104G	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226699&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962850	336293800							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143272	C[C@H]1C[C@H]2CC[C@@H]([C@@H](NC(=O)C3(c4ccc(C(F)(F)F)cc4)CC3)C1)N2c1nnn[nH]1	InChI=1S/C21H25F3N6O/c1-12-10-15-6-7-17(30(15)19-26-28-29-27-19)16(11-12)25-18(31)20(8-9-20)13-2-4-14(5-3-13)21(22,23)24/h2-5,12,15-17H,6-11H2,1H3,(H,25,31)(H,26,27,28,29)	QKUSVBPEEVPWJS-UHFFFAOYSA-N	226700	US20260007684, Compound 104H	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>5000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226700&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962851	336293801							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143273	O=C(N[C@@H]1CCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C16H19ClN6O/c17-12-5-3-11(4-6-12)16(7-8-16)14(24)18-13-2-1-9-23(10-13)15-19-21-22-20-15/h3-6,13H,1-2,7-10H2,(H,18,24)(H,19,20,21,22)	JMWNOZOPDOKJMF-UHFFFAOYSA-N	226351	(R)-N-(1-(1H-tetrazol-5-yl)piperidin-3-yl)- 1-(4-chlorophenyl)cyclopropane-1- carboxamide::US20260007684, Compound 10A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 9500							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226351&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118506855	336293498							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143274	O=C(N[C@@H]1CCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C16H19ClN6O2/c17-10-3-4-12(13(24)8-10)16(5-6-16)14(25)18-11-2-1-7-23(9-11)15-19-21-22-20-15/h3-4,8,11,24H,1-2,5-7,9H2,(H,18,25)(H,19,20,21,22)	DIXHDTLKBKVDTI-UHFFFAOYSA-N	226370	(R)-N-(1-(1H-tetrazol-5-yl)piperidin-3-yl)- 1-(4-chloro-2-hydroxyphenyl)cyclopropane- 1-carboxamide::US20260007684, Compound 15A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 1800							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226370&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505210	336293517							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143275	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C17H21ClN6O/c1-11-8-14(10-24(9-11)16-20-22-23-21-16)19-15(25)17(6-7-17)12-2-4-13(18)5-3-12/h2-5,11,14H,6-10H2,1H3,(H,19,25)(H,20,21,22,23)	AUMOFTLPIFMXOV-UHFFFAOYSA-N	226501	1-(4-chlorophenyl)-N-((3R,5S)-5-methyl-1- (1H-tetrazol-5-yl)piperidin-3- yl)cyclopropane-1-carboxamide::US20260007684, Compound 46A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 860							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226501&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962658	336293603							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143276	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C17H21ClN6O2/c1-10-6-12(9-24(8-10)16-20-22-23-21-16)19-15(26)17(4-5-17)13-3-2-11(18)7-14(13)25/h2-3,7,10,12,25H,4-6,8-9H2,1H3,(H,19,26)(H,20,21,22,23)	AXCDISYORWMTTC-UHFFFAOYSA-N	226504	1-(4-chloro-2-hydroxyphenyl)-N-((3R,5S)- 5-methyl-1-(1H-tetrazol-5-yl)piperidin-3- yl)cyclopropane-1-carboxamide::US20260007684, Compound 47A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 48.0							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226504&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962661	336293606							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143277	CC1(C)C[C@@H](NC(=O)C2(c3ccc(Cl)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H23ClN6O2/c1-17(2)8-12(9-25(10-17)16-21-23-24-22-16)20-15(27)18(5-6-18)13-4-3-11(19)7-14(13)26/h3-4,7,12,26H,5-6,8-10H2,1-2H3,(H,20,27)(H,21,22,23,24)	WFDAUECEKVNKBN-UHFFFAOYSA-N	226490	(R)-1-(4-chloro-2-hydroxyphenyl)-N-(5,5- dimethyl-1-(1H-tetrazol-5-yl)piperidin-3- yl)cyclopropane-1-carboxamide::US20260007684, Compound 42A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 47.0							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226490&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962647	336293592							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143278	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(C(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H21F3N6O2/c1-10-6-12(9-27(8-10)16-23-25-26-24-16)22-15(29)17(4-5-17)13-3-2-11(7-14(13)28)18(19,20)21/h2-3,7,10,12,28H,4-6,8-9H2,1H3,(H,22,29)(H,23,24,25,26)	RMVCTKCJUZBWOV-UHFFFAOYSA-N	226371	1-(2-hydroxy-4-(trifluoromethyl)phenyl)-N- ((3R,5S)-5-methyl-1-(1H-tetrazol-5- yl)piperidin-3-yl)cyclopropane-1- carboxamide::US20260007684, Compound 16A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 41.0							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226371&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505211	336293518							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143279	C[C@H]1C[C@@H](NC(=O)C2(c3ccc(OC(F)(F)F)cc3O)CC2)CN(c2nnn[nH]2)C1	InChI=1S/C18H21F3N6O3/c1-10-6-11(9-27(8-10)16-23-25-26-24-16)22-15(29)17(4-5-17)13-3-2-12(7-14(13)28)30-18(19,20)21/h2-3,7,10-11,28H,4-6,8-9H2,1H3,(H,22,29)(H,23,24,25,26)	UOPIQGJQXMPOPE-UHFFFAOYSA-N	226372	1-(2-hydroxy-4-(trifluoromethoxy)phenyl)- N-((3R,5S)-5-methyl-1-(1H-tetrazol-5- yl)piperidin-3-yl)cyclopropane-1- carboxamide::US20260007684, Compound 17A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 98.0							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226372&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			118505213	336293519							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143280	C[C@@H]1C[C@@H](NC(=O)C2(c3ccc(Cl)cc3)CC2)[C@H]2CC[C@@H]1N2c1nnn[nH]1	InChI=1S/C19H23ClN6O/c1-11-10-14(16-7-6-15(11)26(16)18-22-24-25-23-18)21-17(27)19(8-9-19)12-2-4-13(20)5-3-12/h2-5,11,14-16H,6-10H2,1H3,(H,21,27)(H,22,23,24,25)	UIIUHHNJWKPSEL-UHFFFAOYSA-N	226611	1-(4-chlorophenyl)-N-((1R,2R,4R,5S)-4- methyl-8-(1H-tetrazol-5-yl)-8- azabicyclo[3.2.1]octan-2-yl)cyclopropane- 1-carboxamide::US20260007684, Compound 80A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 130							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226611&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962764	336293712							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143281	O=C(N[C@@H]1CCCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C17H21ClN6O/c18-13-6-4-12(5-7-13)17(8-9-17)15(25)19-14-3-1-2-10-24(11-14)16-20-22-23-21-16/h4-7,14H,1-3,8-11H2,(H,19,25)(H,20,21,22,23)	AOLWXRZIMIKCKO-UHFFFAOYSA-N	226510	1-(4-chlorophenyl)-N-[(3R)-1-(1H-tetrazol- 5-yl)azepan-3-yl]cyclopropanecarboxamide::US20260007684, Compound 51A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 2200							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226510&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962667	336293612							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143282	O=C(N[C@@H]1CCCCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C17H21ClN6O2/c18-11-4-5-13(14(25)9-11)17(6-7-17)15(26)19-12-3-1-2-8-24(10-12)16-20-22-23-21-16/h4-5,9,12,25H,1-3,6-8,10H2,(H,19,26)(H,20,21,22,23)	YBXVHCUTLYGFTE-UHFFFAOYSA-N	226511	(R)-N-(1-(1H-tetrazol-5-yl)azepan-3-yl)-1- (4-chloro-2-hydroxyphenyl)cyclopropane-1- carboxamide::US20260007684, Compound 52A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 79.0							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226511&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962668	336293613							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143283	O=C(N[C@@H]1CCC[C@@H]2CC[C@H]1N2c1nnn[nH]1)C1(c2ccc(Cl)cc2O)CC1	InChI=1S/C19H23ClN6O2/c20-11-4-6-13(16(27)10-11)19(8-9-19)17(28)21-14-3-1-2-12-5-7-15(14)26(12)18-22-24-25-23-18/h4,6,10,12,14-15,27H,1-3,5,7-9H2,(H,21,28)(H,22,23,24,25)	IHFVYAKOOABESX-UHFFFAOYSA-N	226659	N-((1R,2R,6R)-9-(1H-tetrazol-5-yl)-9- azabicyclo[4.2.1]nonan-2-yl)-1-(4-chloro-2- hydroxyphenyl)cyclopropane-1- carboxamide::US20260007684, Compound 92A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 60.0							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226659&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962811	336293760							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143284	O=C(N[C@@H]1CCN(c2nnn[nH]2)C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C15H17ClN6O/c16-11-3-1-10(2-4-11)15(6-7-15)13(23)17-12-5-8-22(9-12)14-18-20-21-19-14/h1-4,12H,5-9H2,(H,17,23)(H,18,19,20,21)	OPNJQBHBRYFBHS-UHFFFAOYSA-N	226701	(R)-N-(1-(1H-tetrazol-5-yl)pyrrolidin-3-yl)- 1-(4-chlorophenyl)cyclopropane-1- carboxamide::US20260007684, Compound Comparative-Example-A	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 420000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226701&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962852	336293802							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143285	O=C(NC1=CC(c2nnn[nH]2)CC=C1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C17H16ClN5O/c18-13-6-4-12(5-7-13)17(8-9-17)16(24)19-14-3-1-2-11(10-14)15-20-22-23-21-15/h1,3-7,10-11H,2,8-9H2,(H,19,24)(H,20,21,22,23)	YOZLXKHKZCKXKZ-UHFFFAOYSA-N	226702	N-(3-(1H-tetrazol-5-yl)phenyl)-1-(4- chlorophenyl)cyclopropane-1-carboxamide CAS Reg. No. 1197529-87-5::US20260007684, Compound Comparative-Example-B1	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 8000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226702&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962853	336293803							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143286	CN(C(=O)C1(c2ccc(Cl)cc2)CC1)c1cccc(-c2nnn[nH]2)c1	InChI=1S/C18H16ClN5O/c1-24(15-4-2-3-12(11-15)16-20-22-23-21-16)17(25)18(9-10-18)13-5-7-14(19)8-6-13/h2-8,11H,9-10H2,1H3,(H,20,21,22,23)	XHIUOLJDPBJNDR-UHFFFAOYSA-N	226703	N-(3-(1H-tetrazol-5-yl)phenyl)-1-(4- chlorophenyl)-N-methylcyclopropane-1- carboxamide::US20260007684, Compound Comparative-Example-B2	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 200000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226703&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962854	336293804							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143287	O=C(Nc1cccc(-c2ccccc2)c1)C1(c2ccc(Cl)cc2)CC1	InChI=1S/C22H18ClNO/c23-19-11-9-18(10-12-19)22(13-14-22)21(25)24-20-8-4-7-17(15-20)16-5-2-1-3-6-16/h1-12,15H,13-14H2,(H,24,25)	GWHFHIBDHJJIOQ-UHFFFAOYSA-N	226704	N-([1,1'-biphenyl]-3-yl)-1-(4- chlorophenyl)cyclopropane-1-carboxamide::US20260007684, Compound Comparative-Example-D	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		 320000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226704&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962855	336293805							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143288	Cn1nnnc1-c1cccc(NC(=O)C2(c3ccc(Cl)cc3)CC2)c1	InChI=1S/C18H16ClN5O/c1-24-16(21-22-23-24)12-3-2-4-15(11-12)20-17(25)18(9-10-18)13-5-7-14(19)8-6-13/h2-8,11H,9-10H2,1H3,(H,20,25)	ITQZXFZUAWGCGI-UHFFFAOYSA-N	226705	1-(4-chlorophenyl)-N-(3-(1-methyl-1H- tetrazol-5-yl)phenyl)cyclopropane-1- carboxamide::US20260007684, Compound Comparative-Example-E1	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>500000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226705&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962856	336293806							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143289	Cn1nnc(-c2cccc(NC(=O)C3(c4ccc(Cl)cc4)CC3)c2)n1	InChI=1S/C18H16ClN5O/c1-24-22-16(21-23-24)12-3-2-4-15(11-12)20-17(25)18(9-10-18)13-5-7-14(19)8-6-13/h2-8,11H,9-10H2,1H3,(H,20,25)	HLHMMIJSHPFOHS-UHFFFAOYSA-N	226706	1-(4-chlorophenyl)-N-(3-(2-methyl-2H- tetrazol-5-yl)phenyl)cyclopropane-1- carboxamide::US20260007684, Compound Comparative-Example-E2	NACHT, LRR and PYD domains-containing protein 3	Homo sapiens		>500000							US Patent		10.7270/Q2M61R2N			US20260007684	DORICH, S; BEVERIDGE, RE; CIBLAT, S; C&#212;T&#201;, A; CYR, P; ST-ONGE, M	1/8/2026	5/20/2026	Ventus Therapeutics U.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226706&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search			126962857	336293807							1	MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW	9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ	NACHT, LRR and PYD domains-containing protein 3	NLRP3_HUMAN	Q96P20	A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9