BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
143418	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-25(2)13-19(27)21(28)24-17(12-23)10-14-4-6-15(7-5-14)16-8-9-20-18(11-16)26(3)22(29)30-20/h4-9,11,17,19,27H,10,13H2,1-3H3,(H,24,28)	JNHISLFGMOSWCR-UHFFFAOYSA-N	226835	US20260008758, Compound 101	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226835&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962983	336293936							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143419	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-25(2)13-19(27)21(28)24-17(12-23)10-14-4-6-15(7-5-14)16-8-9-20-18(11-16)26(3)22(29)30-20/h4-9,11,17,19,27H,10,13H2,1-3H3,(H,24,28)	JNHISLFGMOSWCR-UHFFFAOYSA-N	226835	US20260008758, Compound 101	Dipeptidyl peptidase 1	Mus musculus		 12.5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226835&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962983	336293936							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143420	CO[C@@H](CN)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O4/c1-25-17-10-15(7-8-18(17)29-21(25)27)14-5-3-13(4-6-14)9-16(11-22)24-20(26)19(12-23)28-2/h3-8,10,16,19H,9,12,23H2,1-2H3,(H,24,26)	QECJGBBDSDROMN-UHFFFAOYSA-N	226836	US20260008758, Compound 103	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226836&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962984	336293937							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143421	CN(C)C[C@@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-25(2)13-19(27)21(28)24-17(12-23)10-14-4-6-15(7-5-14)16-8-9-20-18(11-16)26(3)22(29)30-20/h4-9,11,17,19,27H,10,13H2,1-3H3,(H,24,28)	JNHISLFGMOSWCR-UHFFFAOYSA-N	226837	US20260008758, Compound 104	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226837&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962985	336293938							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143422	CO[C@@H](CN(C)C)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H26N4O4/c1-26(2)14-21(30-4)22(28)25-18(13-24)11-15-5-7-16(8-6-15)17-9-10-20-19(12-17)27(3)23(29)31-20/h5-10,12,18,21H,11,14H2,1-4H3,(H,25,28)	ILQCPFZMWOQEEL-UHFFFAOYSA-N	226838	US20260008758, Compound 105	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226838&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962986	336293939							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143423	CNC[C@H](OC)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-24-13-20(29-3)21(27)25-17(12-23)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)26(2)22(28)30-19/h4-9,11,17,20,24H,10,13H2,1-3H3,(H,25,27)	ITHQECXEEFYHEQ-UHFFFAOYSA-N	226839	US20260008758, Compound 109	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226839&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962987	336293940							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143424	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](O)CN)cc3)cc21	InChI=1S/C20H20N4O4/c1-24-16-9-14(6-7-18(16)28-20(24)27)13-4-2-12(3-5-13)8-15(10-21)23-19(26)17(25)11-22/h2-7,9,15,17,25H,8,11,22H2,1H3,(H,23,26)	OHISLHOSOLQLHV-UHFFFAOYSA-N	226840	US20260008758, Compound 110	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226840&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962988	336293941							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143425	CNC[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O4/c1-23-12-18(26)20(27)24-16(11-22)9-13-3-5-14(6-4-13)15-7-8-19-17(10-15)25(2)21(28)29-19/h3-8,10,16,18,23,26H,9,12H2,1-2H3,(H,24,27)	GBHDSUDWHFOXPU-UHFFFAOYSA-N	226841	US20260008758, Compound 111	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226841&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962989	336293942							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143426	CO[C@H](CN(C)C)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H26N4O4/c1-26(2)14-21(30-4)22(28)25-18(13-24)11-15-5-7-16(8-6-15)17-9-10-20-19(12-17)27(3)23(29)31-20/h5-10,12,18,21H,11,14H2,1-4H3,(H,25,28)	ILQCPFZMWOQEEL-UHFFFAOYSA-N	226842	US20260008758, Compound 112	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226842&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962990	336293943							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143427	CN(C)C[C@@H](O)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H26N4O4/c1-26(2)14-19(28)12-22(29)25-18(13-24)10-15-4-6-16(7-5-15)17-8-9-21-20(11-17)27(3)23(30)31-21/h4-9,11,18-19,28H,10,12,14H2,1-3H3,(H,25,29)	ADVKQUKUWWHXER-UHFFFAOYSA-N	226843	US20260008758, Compound 113	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226843&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962991	336293944							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143428	CCN(CC)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C24H28N4O4/c1-4-28(5-2)15-21(29)23(30)26-19(14-25)12-16-6-8-17(9-7-16)18-10-11-22-20(13-18)27(3)24(31)32-22/h6-11,13,19,21,29H,4-5,12,15H2,1-3H3,(H,26,30)	YHZJMMYAGXZWDV-UHFFFAOYSA-N	226844	US20260008758, Compound 115	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226844&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962992	336293945							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143429	CCN(CC)C[C@@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C24H28N4O4/c1-4-28(5-2)15-21(29)23(30)26-19(14-25)12-16-6-8-17(9-7-16)18-10-11-22-20(13-18)27(3)24(31)32-22/h6-11,13,19,21,29H,4-5,12,15H2,1-3H3,(H,26,30)	YHZJMMYAGXZWDV-UHFFFAOYSA-N	226845	US20260008758, Compound 116	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226845&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962635	336293946							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143430	CN(C)C[C@H](O)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H26N4O4/c1-26(2)14-19(28)12-22(29)25-18(13-24)10-15-4-6-16(7-5-15)17-8-9-21-20(11-17)27(3)23(30)31-21/h4-9,11,18-19,28H,10,12,14H2,1-3H3,(H,25,29)	ADVKQUKUWWHXER-UHFFFAOYSA-N	226846	US20260008758, Compound 118	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226846&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962993	336293947							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143431	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](O)CN4CCOCC4)cc3)cc21	InChI=1S/C24H26N4O5/c1-27-20-13-18(6-7-22(20)33-24(27)31)17-4-2-16(3-5-17)12-19(14-25)26-23(30)21(29)15-28-8-10-32-11-9-28/h2-7,13,19,21,29H,8-12,15H2,1H3,(H,26,30)	GVAGBNVHGFZSII-UHFFFAOYSA-N	226847	US20260008758, Compound 121	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226847&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962994	336293948							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143432	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3c(c2)C2(CN(C)C2)OC3=O)cc1	InChI=1S/C25H28N4O4/c1-28(2)13-22(30)23(31)27-19(12-26)10-16-4-6-17(7-5-16)18-8-9-20-21(11-18)25(33-24(20)32)14-29(3)15-25/h4-9,11,19,22,30H,10,13-15H2,1-3H3,(H,27,31)	JAYWZXMUQUNFDF-UHFFFAOYSA-N	226848	US20260008758, Compound 137	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226848&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962995	336293949							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143433	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3c(c2)C2(CN(C)C2)OC3=O)cc1	InChI=1S/C25H28N4O4/c1-28(2)13-22(30)23(31)27-19(12-26)10-16-4-6-17(7-5-16)18-8-9-20-21(11-18)25(33-24(20)32)14-29(3)15-25/h4-9,11,19,22,30H,10,13-15H2,1-3H3,(H,27,31)	JAYWZXMUQUNFDF-UHFFFAOYSA-N	226848	US20260008758, Compound 137	Dipeptidyl peptidase 1	Mus musculus		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226848&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962995	336293949							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143434	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1F	InChI=1S/C22H23FN4O4/c1-26(2)12-19(28)21(29)25-16(11-24)8-15-5-4-13(9-17(15)23)14-6-7-20-18(10-14)27(3)22(30)31-20/h4-7,9-10,16,19,28H,8,12H2,1-3H3,(H,25,29)	HUWSRZFMRRTESY-UHFFFAOYSA-N	226849	US20260008758, Compound 138	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226849&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962996	336293950							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143435	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1F	InChI=1S/C22H23FN4O4/c1-26(2)12-19(28)21(29)25-16(11-24)8-15-5-4-13(9-17(15)23)14-6-7-20-18(10-14)27(3)22(30)31-20/h4-7,9-10,16,19,28H,8,12H2,1-3H3,(H,25,29)	HUWSRZFMRRTESY-UHFFFAOYSA-N	226849	US20260008758, Compound 138	Dipeptidyl peptidase 1	Mus musculus		 12.5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226849&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962996	336293950							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143436	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(CCN4CCOCC4)c3c2)cc1	InChI=1S/C27H33N5O5/c1-30(2)18-24(33)26(34)29-22(17-28)15-19-3-5-20(6-4-19)21-7-8-25-23(16-21)32(27(35)37-25)10-9-31-11-13-36-14-12-31/h3-8,16,22,24,33H,9-15,18H2,1-2H3,(H,29,34)	IFJNRRMQAMOTEU-UHFFFAOYSA-N	226850	US20260008758, Compound 140	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226850&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962997	336293951							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143437	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(CCN4CCOCC4)c3c2)cc1	InChI=1S/C27H33N5O5/c1-30(2)18-24(33)26(34)29-22(17-28)15-19-3-5-20(6-4-19)21-7-8-25-23(16-21)32(27(35)37-25)10-9-31-11-13-36-14-12-31/h3-8,16,22,24,33H,9-15,18H2,1-2H3,(H,29,34)	IFJNRRMQAMOTEU-UHFFFAOYSA-N	226850	US20260008758, Compound 140	Dipeptidyl peptidase 1	Mus musculus		 12.5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226850&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962997	336293951							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143438	CN[C@H](C)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-13(23-2)20(26)24-17(12-22)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)25(3)21(27)28-19/h4-9,11,13,17,23H,10H2,1-3H3,(H,24,26)	HEUXITMADZJTAJ-UHFFFAOYSA-N	226851	US20260008758, Compound 152	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226851&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962998	336293952							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143439	CN[C@H](C)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-13(23-2)20(26)24-17(12-22)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)25(3)21(27)28-19/h4-9,11,13,17,23H,10H2,1-3H3,(H,24,26)	HEUXITMADZJTAJ-UHFFFAOYSA-N	226851	US20260008758, Compound 152	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226851&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962998	336293952							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143440	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCC(N)=O)cc3)cc21	InChI=1S/C21H20N4O4/c1-25-17-11-15(6-7-18(17)29-21(25)28)14-4-2-13(3-5-14)10-16(12-22)24-20(27)9-8-19(23)26/h2-7,11,16H,8-10H2,1H3,(H2,23,26)(H,24,27)	QHLJCQFBLAYDNT-UHFFFAOYSA-N	226852	US20260008758, Compound 153	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226852&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962999	336293953							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143441	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCC(N)=O)cc3)cc21	InChI=1S/C21H20N4O4/c1-25-17-11-15(6-7-18(17)29-21(25)28)14-4-2-13(3-5-14)10-16(12-22)24-20(27)9-8-19(23)26/h2-7,11,16H,8-10H2,1H3,(H2,23,26)(H,24,27)	QHLJCQFBLAYDNT-UHFFFAOYSA-N	226852	US20260008758, Compound 153	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226852&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962999	336293953							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143442	CN[C@@H](C)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-13(23-2)20(26)24-17(12-22)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)25(3)21(27)28-19/h4-9,11,13,17,23H,10H2,1-3H3,(H,24,26)	HEUXITMADZJTAJ-UHFFFAOYSA-N	226853	US20260008758, Compound 154	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226853&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963000	336293954							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143443	CN[C@@H](C)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-13(23-2)20(26)24-17(12-22)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)25(3)21(27)28-19/h4-9,11,13,17,23H,10H2,1-3H3,(H,24,26)	HEUXITMADZJTAJ-UHFFFAOYSA-N	226853	US20260008758, Compound 154	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226853&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963000	336293954							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143444	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(C)CN)cc3)cc21	InChI=1S/C22H24N4O3/c1-22(2,13-24)20(27)25-17(12-23)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)26(3)21(28)29-19/h4-9,11,17H,10,13,24H2,1-3H3,(H,25,27)	MOXFMFAWJOLJOY-UHFFFAOYSA-N	226854	US20260008758, Compound 155	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226854&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963001	336293955							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143445	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(C)CN)cc3)cc21	InChI=1S/C22H24N4O3/c1-22(2,13-24)20(27)25-17(12-23)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)26(3)21(28)29-19/h4-9,11,17H,10,13,24H2,1-3H3,(H,25,27)	MOXFMFAWJOLJOY-UHFFFAOYSA-N	226854	US20260008758, Compound 155	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226854&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963001	336293955							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143446	CNCCC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-23-10-9-20(26)24-17(13-22)11-14-3-5-15(6-4-14)16-7-8-19-18(12-16)25(2)21(27)28-19/h3-8,12,17,23H,9-11H2,1-2H3,(H,24,26)	JTMDTTFSBCFWII-UHFFFAOYSA-N	226855	US20260008758, Compound 156	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226855&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963002	336293956							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143447	CNCCC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-23-10-9-20(26)24-17(13-22)11-14-3-5-15(6-4-14)16-7-8-19-18(12-16)25(2)21(27)28-19/h3-8,12,17,23H,9-11H2,1-2H3,(H,24,26)	JTMDTTFSBCFWII-UHFFFAOYSA-N	226855	US20260008758, Compound 156	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226855&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963002	336293956							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143448	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCN)cc3)cc21	InChI=1S/C20H20N4O3/c1-24-17-11-15(6-7-18(17)27-20(24)26)14-4-2-13(3-5-14)10-16(12-22)23-19(25)8-9-21/h2-7,11,16H,8-10,21H2,1H3,(H,23,25)	PWFXWMGPBQGYDZ-UHFFFAOYSA-N	226856	US20260008758, Compound 157	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226856&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963003	336293957							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143449	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCN)cc3)cc21	InChI=1S/C20H20N4O3/c1-24-17-11-15(6-7-18(17)27-20(24)26)14-4-2-13(3-5-14)10-16(12-22)23-19(25)8-9-21/h2-7,11,16H,8-10,21H2,1H3,(H,23,25)	PWFXWMGPBQGYDZ-UHFFFAOYSA-N	226856	US20260008758, Compound 157	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226856&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963003	336293957							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143450	CN(C)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-24(2)13-20(26)23-17(12-22)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)25(3)21(27)28-19/h4-9,11,17H,10,13H2,1-3H3,(H,23,26)	SHJOMEIEOBYZKM-UHFFFAOYSA-N	226857	US20260008758, Compound 158	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226857&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963004	336293958							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143451	CN(C)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-24(2)13-20(26)23-17(12-22)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)25(3)21(27)28-19/h4-9,11,17H,10,13H2,1-3H3,(H,23,26)	SHJOMEIEOBYZKM-UHFFFAOYSA-N	226857	US20260008758, Compound 158	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226857&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963004	336293958							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143452	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)C(N)=O)cc3)cc21	InChI=1S/C21H21N5O4/c1-26-17-9-14(6-7-18(17)30-21(26)29)13-4-2-12(3-5-13)8-15(11-22)25-19(27)10-16(23)20(24)28/h2-7,9,15-16H,8,10,23H2,1H3,(H2,24,28)(H,25,27)	ZANVKOXIEHRWKB-UHFFFAOYSA-N	226858	US20260008758, Compound 159	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226858&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963005	336293959							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143453	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)C(N)=O)cc3)cc21	InChI=1S/C21H21N5O4/c1-26-17-9-14(6-7-18(17)30-21(26)29)13-4-2-12(3-5-13)8-15(11-22)25-19(27)10-16(23)20(24)28/h2-7,9,15-16H,8,10,23H2,1H3,(H2,24,28)(H,25,27)	ZANVKOXIEHRWKB-UHFFFAOYSA-N	226858	US20260008758, Compound 159	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226858&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963005	336293959							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143454	CC(N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-13(23)9-20(26)24-17(12-22)10-14-3-5-15(6-4-14)16-7-8-19-18(11-16)25(2)21(27)28-19/h3-8,11,13,17H,9-10,23H2,1-2H3,(H,24,26)	HENBNVNRGOUTLQ-UHFFFAOYSA-N	226859	US20260008758, Compound 160	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226859&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963006	336293960							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143455	CC(N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-13(23)9-20(26)24-17(12-22)10-14-3-5-15(6-4-14)16-7-8-19-18(11-16)25(2)21(27)28-19/h3-8,11,13,17H,9-10,23H2,1-2H3,(H,24,26)	HENBNVNRGOUTLQ-UHFFFAOYSA-N	226859	US20260008758, Compound 160	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226859&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963006	336293960							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143456	CC(CN)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-13(11-22)20(26)24-17(12-23)9-14-3-5-15(6-4-14)16-7-8-19-18(10-16)25(2)21(27)28-19/h3-8,10,13,17H,9,11,22H2,1-2H3,(H,24,26)	BFYPHAKQKXVDHA-UHFFFAOYSA-N	226860	US20260008758, Compound 161	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226860&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963007	336293961							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143457	CC(CN)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O3/c1-13(11-22)20(26)24-17(12-23)9-14-3-5-15(6-4-14)16-7-8-19-18(10-16)25(2)21(27)28-19/h3-8,10,13,17H,9,11,22H2,1-2H3,(H,24,26)	BFYPHAKQKXVDHA-UHFFFAOYSA-N	226860	US20260008758, Compound 161	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226860&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963007	336293961							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143458	CCC(N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O3/c1-3-17(24)12-21(27)25-18(13-23)10-14-4-6-15(7-5-14)16-8-9-20-19(11-16)26(2)22(28)29-20/h4-9,11,17-18H,3,10,12,24H2,1-2H3,(H,25,27)	PXQCAQOTFYMTRT-UHFFFAOYSA-N	226861	US20260008758, Compound 162	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226861&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963008	336293962							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143459	CCC(N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O3/c1-3-17(24)12-21(27)25-18(13-23)10-14-4-6-15(7-5-14)16-8-9-20-19(11-16)26(2)22(28)29-20/h4-9,11,17-18H,3,10,12,24H2,1-2H3,(H,25,27)	PXQCAQOTFYMTRT-UHFFFAOYSA-N	226861	US20260008758, Compound 162	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226861&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963008	336293962							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143460	C=CC[C@H](N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H24N4O3/c1-3-4-18(25)13-22(28)26-19(14-24)11-15-5-7-16(8-6-15)17-9-10-21-20(12-17)27(2)23(29)30-21/h3,5-10,12,18-19H,1,4,11,13,25H2,2H3,(H,26,28)	VOJYPXOPYJTACZ-UHFFFAOYSA-N	226862	US20260008758, Compound 163	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226862&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963009	336293963							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143461	C=CC[C@H](N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H24N4O3/c1-3-4-18(25)13-22(28)26-19(14-24)11-15-5-7-16(8-6-15)17-9-10-21-20(12-17)27(2)23(29)30-21/h3,5-10,12,18-19H,1,4,11,13,25H2,2H3,(H,26,28)	VOJYPXOPYJTACZ-UHFFFAOYSA-N	226862	US20260008758, Compound 163	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226862&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963009	336293963							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
143462	CC(C)C(N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H26N4O3/c1-14(2)19(25)12-22(28)26-18(13-24)10-15-4-6-16(7-5-15)17-8-9-21-20(11-17)27(3)23(29)30-21/h4-9,11,14,18-19H,10,12,25H2,1-3H3,(H,26,28)	HICMDBMTQRCFKG-UHFFFAOYSA-N	226863	US20260008758, Compound 164	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226863&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963010	336293964							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147859	CC(C)C(N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H26N4O3/c1-14(2)19(25)12-22(28)26-18(13-24)10-15-4-6-16(7-5-15)17-8-9-21-20(11-17)27(3)23(29)30-21/h4-9,11,14,18-19H,10,12,25H2,1-3H3,(H,26,28)	HICMDBMTQRCFKG-UHFFFAOYSA-N	226863	US20260008758, Compound 164	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226863&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963010	336293964							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147860	C=CC[C@@H](N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H24N4O3/c1-3-4-18(25)13-22(28)26-19(14-24)11-15-5-7-16(8-6-15)17-9-10-21-20(12-17)27(2)23(29)30-21/h3,5-10,12,18-19H,1,4,11,13,25H2,2H3,(H,26,28)	VOJYPXOPYJTACZ-UHFFFAOYSA-N	226864	US20260008758, Compound 165	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226864&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963011	336293965							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147861	C=CC[C@@H](N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H24N4O3/c1-3-4-18(25)13-22(28)26-19(14-24)11-15-5-7-16(8-6-15)17-9-10-21-20(12-17)27(2)23(29)30-21/h3,5-10,12,18-19H,1,4,11,13,25H2,2H3,(H,26,28)	VOJYPXOPYJTACZ-UHFFFAOYSA-N	226864	US20260008758, Compound 165	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226864&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963011	336293965							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147862	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)C(F)F)cc3)cc21	InChI=1S/C21H20F2N4O3/c1-27-17-9-14(6-7-18(17)30-21(27)29)13-4-2-12(3-5-13)8-15(11-24)26-19(28)10-16(25)20(22)23/h2-7,9,15-16,20H,8,10,25H2,1H3,(H,26,28)	LAKIBDXKNRKEHU-UHFFFAOYSA-N	226865	US20260008758, Compound 166	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226865&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963012	336293966							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147863	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)C(F)F)cc3)cc21	InChI=1S/C21H20F2N4O3/c1-27-17-9-14(6-7-18(17)30-21(27)29)13-4-2-12(3-5-13)8-15(11-24)26-19(28)10-16(25)20(22)23/h2-7,9,15-16,20H,8,10,25H2,1H3,(H,26,28)	LAKIBDXKNRKEHU-UHFFFAOYSA-N	226865	US20260008758, Compound 166	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226865&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963012	336293966							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147864	C=CCC(CN)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H24N4O3/c1-3-4-18(13-24)22(28)26-19(14-25)11-15-5-7-16(8-6-15)17-9-10-21-20(12-17)27(2)23(29)30-21/h3,5-10,12,18-19H,1,4,11,13,24H2,2H3,(H,26,28)	KKYBEFAXLAYTLX-UHFFFAOYSA-N	226866	US20260008758, Compound 167	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226866&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963013	336293967							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147865	C=CCC(CN)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H24N4O3/c1-3-4-18(13-24)22(28)26-19(14-25)11-15-5-7-16(8-6-15)17-9-10-21-20(12-17)27(2)23(29)30-21/h3,5-10,12,18-19H,1,4,11,13,24H2,2H3,(H,26,28)	KKYBEFAXLAYTLX-UHFFFAOYSA-N	226866	US20260008758, Compound 167	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226866&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963013	336293967							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147866	CC(CO)CC(N)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H26N4O4/c1-14(13-28)9-19(25)22(29)26-18(12-24)10-15-3-5-16(6-4-15)17-7-8-21-20(11-17)27(2)23(30)31-21/h3-8,11,14,18-19,28H,9-10,13,25H2,1-2H3,(H,26,29)	GGAUDOGARGOBRJ-UHFFFAOYSA-N	226867	US20260008758, Compound 168	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226867&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963014	336293968							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147867	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H](N)CCO)cc3)cc21	InChI=1S/C21H22N4O4/c1-25-18-11-15(6-7-19(18)29-21(25)28)14-4-2-13(3-5-14)10-16(12-22)24-20(27)17(23)8-9-26/h2-7,11,16-17,26H,8-10,23H2,1H3,(H,24,27)	RIQFRJPYCQKTRZ-UHFFFAOYSA-N	226868	US20260008758, Compound 169	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226868&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963015	336293969							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147868	CC(C)C(C)(N)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C23H26N4O3/c1-14(2)23(3,25)21(28)26-18(13-24)11-15-5-7-16(8-6-15)17-9-10-20-19(12-17)27(4)22(29)30-20/h5-10,12,14,18H,11,25H2,1-4H3,(H,26,28)	ZYPQNFQHOIJDOF-UHFFFAOYSA-N	226869	US20260008758, Compound 172	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226869&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963016	336293970							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147869	CC(O)CNCC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-14(27)12-24-13-21(28)25-18(11-23)9-15-3-5-16(6-4-15)17-7-8-20-19(10-17)26(2)22(29)30-20/h3-8,10,14,18,24,27H,9,12-13H2,1-2H3,(H,25,28)	BDOCXCBUJHCYPI-UHFFFAOYSA-N	226870	US20260008758, Compound 174	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226870&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963017	336293971							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147870	CC(O)CNCC(=O)N[C@@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-14(27)12-24-13-21(28)25-18(11-23)9-15-3-5-16(6-4-15)17-7-8-20-19(10-17)26(2)22(29)30-20/h3-8,10,14,18,24,27H,9,12-13H2,1-2H3,(H,25,28)	BDOCXCBUJHCYPI-UHFFFAOYSA-N	226871	US20260008758, Compound 175	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226871&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963018	336293972							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147871	CC(O)CNCC(=O)N[C@@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-14(27)12-24-13-21(28)25-18(11-23)9-15-3-5-16(6-4-15)17-7-8-20-19(10-17)26(2)22(29)30-20/h3-8,10,14,18,24,27H,9,12-13H2,1-2H3,(H,25,28)	BDOCXCBUJHCYPI-UHFFFAOYSA-N	226871	US20260008758, Compound 175	Dipeptidyl peptidase 1	Mus musculus		 12.5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226871&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963018	336293972							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147872	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@@H](N)Cc4cccs4)cc3)cc21	InChI=1S/C25H24N4O3S/c1-29-22-12-18(8-9-23(22)32-25(29)31)17-6-4-16(5-7-17)11-20(15-26)28-24(30)14-19(27)13-21-3-2-10-33-21/h2-10,12,19-20H,11,13-14,27H2,1H3,(H,28,30)	JTEKXNCRBFBIFC-UHFFFAOYSA-N	226872	US20260008758, Compound 181	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226872&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963019	336293973							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147873	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@@H](N)Cc4cccs4)cc3)cc21	InChI=1S/C25H24N4O3S/c1-29-22-12-18(8-9-23(22)32-25(29)31)17-6-4-16(5-7-17)11-20(15-26)28-24(30)14-19(27)13-21-3-2-10-33-21/h2-10,12,19-20H,11,13-14,27H2,1H3,(H,28,30)	JTEKXNCRBFBIFC-UHFFFAOYSA-N	226872	US20260008758, Compound 181	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226872&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963019	336293973							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147874	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@H](N)Cc4cccs4)cc3)cc21	InChI=1S/C25H24N4O3S/c1-29-22-12-18(8-9-23(22)32-25(29)31)17-6-4-16(5-7-17)11-20(15-26)28-24(30)14-19(27)13-21-3-2-10-33-21/h2-10,12,19-20H,11,13-14,27H2,1H3,(H,28,30)	JTEKXNCRBFBIFC-UHFFFAOYSA-N	226873	US20260008758, Compound 182	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226873&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963020	336293974							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147875	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@H](N)Cc4cccs4)cc3)cc21	InChI=1S/C25H24N4O3S/c1-29-22-12-18(8-9-23(22)32-25(29)31)17-6-4-16(5-7-17)11-20(15-26)28-24(30)14-19(27)13-21-3-2-10-33-21/h2-10,12,19-20H,11,13-14,27H2,1H3,(H,28,30)	JTEKXNCRBFBIFC-UHFFFAOYSA-N	226873	US20260008758, Compound 182	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226873&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963020	336293974							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147876	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)CCc4ccccc4)cc3)cc21	InChI=1S/C28H28N4O3/c1-32-25-16-22(12-14-26(25)35-28(32)34)21-10-7-20(8-11-21)15-24(18-29)31-27(33)17-23(30)13-9-19-5-3-2-4-6-19/h2-8,10-12,14,16,23-24H,9,13,15,17,30H2,1H3,(H,31,33)	CBAXPRWSPZOCMA-UHFFFAOYSA-N	226874	US20260008758, Compound 183	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226874&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963021	336293975							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147877	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)CCc4ccccc4)cc3)cc21	InChI=1S/C28H28N4O3/c1-32-25-16-22(12-14-26(25)35-28(32)34)21-10-7-20(8-11-21)15-24(18-29)31-27(33)17-23(30)13-9-19-5-3-2-4-6-19/h2-8,10-12,14,16,23-24H,9,13,15,17,30H2,1H3,(H,31,33)	CBAXPRWSPZOCMA-UHFFFAOYSA-N	226874	US20260008758, Compound 183	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226874&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963021	336293975							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147878	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)Cc4ccccc4)cc3)cc21	InChI=1S/C27H26N4O3/c1-31-24-15-21(11-12-25(24)34-27(31)33)20-9-7-19(8-10-20)14-23(17-28)30-26(32)16-22(29)13-18-5-3-2-4-6-18/h2-12,15,22-23H,13-14,16,29H2,1H3,(H,30,32)	JUBKPARWTAZVCN-UHFFFAOYSA-N	226875	US20260008758, Compound 184	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226875&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963022	336293976							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147879	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)Cc4ccccc4)cc3)cc21	InChI=1S/C27H26N4O3/c1-31-24-15-21(11-12-25(24)34-27(31)33)20-9-7-19(8-10-20)14-23(17-28)30-26(32)16-22(29)13-18-5-3-2-4-6-18/h2-12,15,22-23H,13-14,16,29H2,1H3,(H,30,32)	JUBKPARWTAZVCN-UHFFFAOYSA-N	226875	US20260008758, Compound 184	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226875&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963022	336293976							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147880	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)Cc4ccsc4)cc3)cc21	InChI=1S/C25H24N4O3S/c1-29-22-12-19(6-7-23(22)32-25(29)31)18-4-2-16(3-5-18)11-21(14-26)28-24(30)13-20(27)10-17-8-9-33-15-17/h2-9,12,15,20-21H,10-11,13,27H2,1H3,(H,28,30)	ZUVZMFQGABJWQT-UHFFFAOYSA-N	226876	US20260008758, Compound 185	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226876&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963023	336293977							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147881	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)Cc4ccsc4)cc3)cc21	InChI=1S/C25H24N4O3S/c1-29-22-12-19(6-7-23(22)32-25(29)31)18-4-2-16(3-5-18)11-21(14-26)28-24(30)13-20(27)10-17-8-9-33-15-17/h2-9,12,15,20-21H,10-11,13,27H2,1H3,(H,28,30)	ZUVZMFQGABJWQT-UHFFFAOYSA-N	226876	US20260008758, Compound 185	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226876&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963023	336293977							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147882	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@@H](N)Cc4ccccc4)cc3)cc21	InChI=1S/C27H26N4O3/c1-31-24-15-21(11-12-25(24)34-27(31)33)20-9-7-19(8-10-20)14-23(17-28)30-26(32)16-22(29)13-18-5-3-2-4-6-18/h2-12,15,22-23H,13-14,16,29H2,1H3,(H,30,32)	JUBKPARWTAZVCN-UHFFFAOYSA-N	226877	US20260008758, Compound 186	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226877&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963024	336293978							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147883	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@@H](N)Cc4ccccc4)cc3)cc21	InChI=1S/C27H26N4O3/c1-31-24-15-21(11-12-25(24)34-27(31)33)20-9-7-19(8-10-20)14-23(17-28)30-26(32)16-22(29)13-18-5-3-2-4-6-18/h2-12,15,22-23H,13-14,16,29H2,1H3,(H,30,32)	JUBKPARWTAZVCN-UHFFFAOYSA-N	226877	US20260008758, Compound 186	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226877&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963024	336293978							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147891	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@H](N)Cc4ccccc4)cc3)cc21	InChI=1S/C27H26N4O3/c1-31-24-15-21(11-12-25(24)34-27(31)33)20-9-7-19(8-10-20)14-23(17-28)30-26(32)16-22(29)13-18-5-3-2-4-6-18/h2-12,15,22-23H,13-14,16,29H2,1H3,(H,30,32)	JUBKPARWTAZVCN-UHFFFAOYSA-N	226878	US20260008758, Compound 187	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226878&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963025	336293979							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147892	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@H](N)Cc4ccccc4)cc3)cc21	InChI=1S/C27H26N4O3/c1-31-24-15-21(11-12-25(24)34-27(31)33)20-9-7-19(8-10-20)14-23(17-28)30-26(32)16-22(29)13-18-5-3-2-4-6-18/h2-12,15,22-23H,13-14,16,29H2,1H3,(H,30,32)	JUBKPARWTAZVCN-UHFFFAOYSA-N	226878	US20260008758, Compound 187	Dipeptidyl peptidase 1	Mus musculus		>20.0							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226878&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963025	336293979							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147893	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)C4CCCCC4)cc3)cc21	InChI=1S/C26H30N4O3/c1-30-23-14-20(11-12-24(23)33-26(30)32)18-9-7-17(8-10-18)13-21(16-27)29-25(31)15-22(28)19-5-3-2-4-6-19/h7-12,14,19,21-22H,2-6,13,15,28H2,1H3,(H,29,31)	HHFCRRHIZNBVOB-UHFFFAOYSA-N	226879	US20260008758, Compound 188	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226879&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963026	336293980							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147894	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)c4ccccc4)cc3)cc21	InChI=1S/C26H24N4O3/c1-30-23-14-20(11-12-24(23)33-26(30)32)18-9-7-17(8-10-18)13-21(16-27)29-25(31)15-22(28)19-5-3-2-4-6-19/h2-12,14,21-22H,13,15,28H2,1H3,(H,29,31)	ZKCQPHVKSFCILW-UHFFFAOYSA-N	226880	US20260008758, Compound 189	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226880&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963027	336293981							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147895	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)C4CCCCC4)cc3)cc21	InChI=1S/C26H30N4O3/c1-30-23-14-20(11-12-24(23)33-26(30)32)18-9-7-17(8-10-18)13-21(16-27)29-25(31)15-22(28)19-5-3-2-4-6-19/h7-12,14,19,21-22H,2-6,13,15,28H2,1H3,(H,29,31)	HHFCRRHIZNBVOB-UHFFFAOYSA-N	226881	US20260008758, Compound 190	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226881&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963028	336293982							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147896	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(CN)Cc4cccnc4)cc3)cc21	InChI=1S/C26H25N5O3/c1-31-23-13-20(8-9-24(23)34-26(31)33)19-6-4-17(5-7-19)12-22(15-28)30-25(32)21(14-27)11-18-3-2-10-29-16-18/h2-10,13,16,21-22H,11-12,14,27H2,1H3,(H,30,32)	CLROXFPROBPRMT-UHFFFAOYSA-N	226882	US20260008758, Compound 191	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226882&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963029	336293983							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147897	Cc1ccccc1CC(CN)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C28H28N4O3/c1-18-5-3-4-6-21(18)14-23(16-29)27(33)31-24(17-30)13-19-7-9-20(10-8-19)22-11-12-26-25(15-22)32(2)28(34)35-26/h3-12,15,23-24H,13-14,16,29H2,1-2H3,(H,31,33)	YENUPTWEPIHPBC-UHFFFAOYSA-N	226883	US20260008758, Compound 192	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226883&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963030	336293984							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147898	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(CN)Cc4ccccc4F)cc3)cc21	InChI=1S/C28H27FN4O3/c1-28(17-31,15-21-5-3-4-6-23(21)29)26(34)32-22(16-30)13-18-7-9-19(10-8-18)20-11-12-25-24(14-20)33(2)27(35)36-25/h3-12,14,22H,13,15,17,31H2,1-2H3,(H,32,34)	OOHDQTCNQYYFGR-UHFFFAOYSA-N	226884	US20260008758, Compound 196	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226884&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963031	336293985							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147899	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(CN)Cc4c(F)cccc4Cl)cc3)cc21	InChI=1S/C28H26ClFN4O3/c1-28(16-32,14-21-22(29)4-3-5-23(21)30)26(35)33-20(15-31)12-17-6-8-18(9-7-17)19-10-11-25-24(13-19)34(2)27(36)37-25/h3-11,13,20H,12,14,16,32H2,1-2H3,(H,33,35)	OBTLUFRIRVTRDG-UHFFFAOYSA-N	226885	US20260008758, Compound 197	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226885&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963032	336293986							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147900	Cc1ccccc1[C@@H](N)CC(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C27H26N4O3/c1-17-5-3-4-6-22(17)23(29)15-26(32)30-21(16-28)13-18-7-9-19(10-8-18)20-11-12-25-24(14-20)31(2)27(33)34-25/h3-12,14,21,23H,13,15,29H2,1-2H3,(H,30,32)	BQSSMGYFSRZSJR-UHFFFAOYSA-N	226886	US20260008758, Compound 198	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226886&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963033	336293987							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147901	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(N)Cc4cccnc4O)cc3)cc21	InChI=1S/C25H23N5O4/c1-30-21-13-17(8-9-22(21)34-25(30)33)16-6-4-15(5-7-16)11-19(14-26)29-24(32)20(27)12-18-3-2-10-28-23(18)31/h2-10,13,19-20H,11-12,27H2,1H3,(H,28,31)(H,29,32)	VZJRISDONVWTRT-UHFFFAOYSA-N	226887	US20260008758, Compound 199	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226887&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963034	336293988							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147902	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(N)c4ccc(O)cc4)cc3)cc21	InChI=1S/C26H24N4O4/c1-26(28,19-8-10-21(31)11-9-19)24(32)29-20(15-27)13-16-3-5-17(6-4-16)18-7-12-23-22(14-18)30(2)25(33)34-23/h3-12,14,20,31H,13,28H2,1-2H3,(H,29,32)	IEAXTUXLVKLNAV-UHFFFAOYSA-N	226888	US20260008758, Compound 200	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226888&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126962997	336293989							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147903	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(N)Cc4cncs4)cc3)cc21	InChI=1S/C23H21N5O3S/c1-28-20-9-16(6-7-21(20)31-23(28)30)15-4-2-14(3-5-15)8-17(11-24)27-22(29)19(25)10-18-12-26-13-32-18/h2-7,9,12-13,17,19H,8,10,25H2,1H3,(H,27,29)	SBMMRNQHZSUSME-UHFFFAOYSA-N	226889	US20260008758, Compound 201	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226889&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963035	336293990							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147904	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](N)Cc4cccnc4)cc3)cc21	InChI=1S/C25H23N5O3/c1-30-22-13-19(8-9-23(22)33-25(30)32)18-6-4-16(5-7-18)11-20(14-26)29-24(31)21(27)12-17-3-2-10-28-15-17/h2-10,13,15,20-21H,11-12,27H2,1H3,(H,29,31)	CCMCVOITGQEBJY-UHFFFAOYSA-N	226890	US20260008758, Compound 202	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226890&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963036	336293991							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147905	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(N)Cc4ccccc4O)cc3)cc21	InChI=1S/C26H24N4O4/c1-30-22-14-18(10-11-24(22)34-26(30)33)17-8-6-16(7-9-17)12-20(15-27)29-25(32)21(28)13-19-4-2-3-5-23(19)31/h2-11,14,20-21,31H,12-13,28H2,1H3,(H,29,32)	ROOIFDNRDAZBHW-UHFFFAOYSA-N	226896	US20260008758, Compound 203	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226896&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963037	336293992							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147906	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(N)Cc4cocn4)cc3)cc21	InChI=1S/C23H21N5O4/c1-28-20-9-16(6-7-21(20)32-23(28)30)15-4-2-14(3-5-15)8-17(11-24)27-22(29)19(25)10-18-12-31-13-26-18/h2-7,9,12-13,17,19H,8,10,25H2,1H3,(H,27,29)	VCWHSOFQIPTYTH-UHFFFAOYSA-N	226897	US20260008758, Compound 204	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226897&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963038	336293993							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147907	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](N)[C@@H]4CCc5ccccc54)cc3)cc21	InChI=1S/C28H26N4O3/c1-32-24-15-20(11-13-25(24)35-28(32)34)18-8-6-17(7-9-18)14-21(16-29)31-27(33)26(30)23-12-10-19-4-2-3-5-22(19)23/h2-9,11,13,15,21,23,26H,10,12,14,30H2,1H3,(H,31,33)	GRFGGWPFRXSILX-UHFFFAOYSA-N	226898	US20260008758, Compound 206	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226898&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963039	336293994							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147908	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](N)[C@H]4CCc5ccccc54)cc3)cc21	InChI=1S/C28H26N4O3/c1-32-24-15-20(11-13-25(24)35-28(32)34)18-8-6-17(7-9-18)14-21(16-29)31-27(33)26(30)23-12-10-19-4-2-3-5-22(19)23/h2-9,11,13,15,21,23,26H,10,12,14,30H2,1H3,(H,31,33)	GRFGGWPFRXSILX-UHFFFAOYSA-N	226899	US20260008758, Compound 207	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226899&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963040	336293995							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147909	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(N)Cc4cc[nH]c4)cc3)cc21	InChI=1S/C24H23N5O3/c1-29-21-12-18(6-7-22(21)32-24(29)31)17-4-2-15(3-5-17)10-19(13-25)28-23(30)20(26)11-16-8-9-27-14-16/h2-9,12,14,19-20,27H,10-11,26H2,1H3,(H,28,30)	AIHLMONHICOANB-UHFFFAOYSA-N	226900	US20260008758, Compound 208	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226900&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963041	336293996							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147910	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](N)[C@H]4CCCO4)cc3)cc21	InChI=1S/C23H24N4O4/c1-27-18-12-16(8-9-19(18)31-23(27)29)15-6-4-14(5-7-15)11-17(13-24)26-22(28)21(25)20-3-2-10-30-20/h4-9,12,17,20-21H,2-3,10-11,25H2,1H3,(H,26,28)	QBBKHFVFYFTBDC-UHFFFAOYSA-N	226901	US20260008758, Compound 210	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226901&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963042	336293997							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147911	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H](N)[C@H]4CCCO4)cc3)cc21	InChI=1S/C23H24N4O4/c1-27-18-12-16(8-9-19(18)31-23(27)29)15-6-4-14(5-7-15)11-17(13-24)26-22(28)21(25)20-3-2-10-30-20/h4-9,12,17,20-21H,2-3,10-11,25H2,1H3,(H,26,28)	QBBKHFVFYFTBDC-UHFFFAOYSA-N	226902	US20260008758, Compound 211	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226902&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963043	336293998							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147912	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](N)[C@@H]4CCCO4)cc3)cc21	InChI=1S/C23H24N4O4/c1-27-18-12-16(8-9-19(18)31-23(27)29)15-6-4-14(5-7-15)11-17(13-24)26-22(28)21(25)20-3-2-10-30-20/h4-9,12,17,20-21H,2-3,10-11,25H2,1H3,(H,26,28)	QBBKHFVFYFTBDC-UHFFFAOYSA-N	226903	US20260008758, Compound 212	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226903&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963044	336293999							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147913	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H](N)[C@@H]4CCCO4)cc3)cc21	InChI=1S/C23H24N4O4/c1-27-18-12-16(8-9-19(18)31-23(27)29)15-6-4-14(5-7-15)11-17(13-24)26-22(28)21(25)20-3-2-10-30-20/h4-9,12,17,20-21H,2-3,10-11,25H2,1H3,(H,26,28)	QBBKHFVFYFTBDC-UHFFFAOYSA-N	226904	US20260008758, Compound 213	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226904&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963045	336294000							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147914	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](N)Cc4cn[nH]c4)cc3)cc21	InChI=1S/C23H22N6O3/c1-29-20-10-17(6-7-21(20)32-23(29)31)16-4-2-14(3-5-16)8-18(11-24)28-22(30)19(25)9-15-12-26-27-13-15/h2-7,10,12-13,18-19H,8-9,25H2,1H3,(H,26,27)(H,28,30)	KVAOSHLLXFNOIG-UHFFFAOYSA-N	226905	US20260008758, Compound 214	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226905&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963046	336294001							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147915	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H](N)Cc4c[nH]cn4)cc3)cc21	InChI=1S/C23H22N6O3/c1-29-20-9-16(6-7-21(20)32-23(29)31)15-4-2-14(3-5-15)8-17(11-24)28-22(30)19(25)10-18-12-26-13-27-18/h2-7,9,12-13,17,19H,8,10,25H2,1H3,(H,26,27)(H,28,30)	MVKATDBEIPHSPT-UHFFFAOYSA-N	226906	US20260008758, Compound 215	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226906&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963047	336294002							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147916	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(N)c4cccnc4)cc3)cc21	InChI=1S/C25H23N5O3/c1-25(27,19-4-3-11-28-15-19)23(31)29-20(14-26)12-16-5-7-17(8-6-16)18-9-10-22-21(13-18)30(2)24(32)33-22/h3-11,13,15,20H,12,27H2,1-2H3,(H,29,31)	WZHDPFLNRSYJTD-UHFFFAOYSA-N	226907	US20260008758, Compound 216	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226907&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963048	336294003							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147917	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(N)Cc4cncc(O)c4)cc3)cc21	InChI=1S/C25H23N5O4/c1-30-22-11-18(6-7-23(22)34-25(30)33)17-4-2-15(3-5-17)8-19(12-26)29-24(32)21(27)10-16-9-20(31)14-28-13-16/h2-7,9,11,13-14,19,21,31H,8,10,27H2,1H3,(H,29,32)	ZVMNWDXHSPJIKD-UHFFFAOYSA-N	226908	US20260008758, Compound 217	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226908&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963049	336294004							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147918	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(N)Cc4ncsc4Cl)cc3)cc21	InChI=1S/C23H20ClN5O3S/c1-29-19-9-15(6-7-20(19)32-23(29)31)14-4-2-13(3-5-14)8-16(11-25)28-22(30)17(26)10-18-21(24)33-12-27-18/h2-7,9,12,16-17H,8,10,26H2,1H3,(H,28,30)	RGILUJAROQFZEL-UHFFFAOYSA-N	226909	US20260008758, Compound 218	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226909&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963050	336294005							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147919	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(N)C4CCCC4)cc3)cc21	InChI=1S/C25H28N4O3/c1-25(27,19-5-3-4-6-19)23(30)28-20(15-26)13-16-7-9-17(10-8-16)18-11-12-22-21(14-18)29(2)24(31)32-22/h7-12,14,19-20H,3-6,13,27H2,1-2H3,(H,28,30)	JPBSXNHLGQFNGF-UHFFFAOYSA-N	226910	US20260008758, Compound 219	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226910&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963051	336294006							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147920	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(N)C4CCC4)cc3)cc21	InChI=1S/C24H26N4O3/c1-24(26,18-4-3-5-18)22(29)27-19(14-25)12-15-6-8-16(9-7-15)17-10-11-21-20(13-17)28(2)23(30)31-21/h6-11,13,18-19H,3-5,12,26H2,1-2H3,(H,27,29)	KCZJUFOEEBKJFF-UHFFFAOYSA-N	226911	US20260008758, Compound 220	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226911&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963052	336294007							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147921	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(N)Cc4cc[nH]n4)cc3)cc21	InChI=1S/C23H22N6O3/c1-29-20-11-16(6-7-21(20)32-23(29)31)15-4-2-14(3-5-15)10-18(13-24)27-22(30)19(25)12-17-8-9-26-28-17/h2-9,11,18-19H,10,12,25H2,1H3,(H,26,28)(H,27,30)	PWRJCAJGTOXRAV-UHFFFAOYSA-N	226912	US20260008758, Compound 221	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226912&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963053	336294008							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147922	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(N)CCCC45CC5)cc3)cc21	InChI=1S/C25H26N4O3/c1-29-20-14-18(7-8-21(20)32-23(29)31)17-5-3-16(4-6-17)13-19(15-26)28-22(30)25(27)10-2-9-24(25)11-12-24/h3-8,14,19H,2,9-13,27H2,1H3,(H,28,30)	XUSMIHCHOIPSAP-UHFFFAOYSA-N	226913	US20260008758, Compound 222	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226913&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963054	336294009							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147923	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)c4cocn4)cc3)cc21	InChI=1S/C23H21N5O4/c1-28-20-9-16(6-7-21(20)32-23(28)30)15-4-2-14(3-5-15)8-17(11-24)27-22(29)10-18(25)19-12-31-13-26-19/h2-7,9,12-13,17-18H,8,10,25H2,1H3,(H,27,29)	GBZTVCYTSLLDJG-UHFFFAOYSA-N	226914	US20260008758, Compound 229	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226914&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963055	336294010							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147924	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCNC(=O)c4cccs4)cc3)cc21	InChI=1S/C25H22N4O4S/c1-29-20-14-18(8-9-21(20)33-25(29)32)17-6-4-16(5-7-17)13-19(15-26)28-23(30)10-11-27-24(31)22-3-2-12-34-22/h2-9,12,14,19H,10-11,13H2,1H3,(H,27,31)(H,28,30)	OLEGYFIFTZQODH-UHFFFAOYSA-N	226915	US20260008758, Compound 238	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226915&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963056	336294011							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147925	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCNC(=O)c4cccs4)cc3)cc21	InChI=1S/C25H22N4O4S/c1-29-20-14-18(8-9-21(20)33-25(29)32)17-6-4-16(5-7-17)13-19(15-26)28-23(30)10-11-27-24(31)22-3-2-12-34-22/h2-9,12,14,19H,10-11,13H2,1H3,(H,27,31)(H,28,30)	OLEGYFIFTZQODH-UHFFFAOYSA-N	226915	US20260008758, Compound 238	Dipeptidyl peptidase 1	Mus musculus		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226915&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963056	336294011							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147926	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CNC(=O)c4cccs4)cc3)cc21	InChI=1S/C24H20N4O4S/c1-28-19-12-17(8-9-20(19)32-24(28)31)16-6-4-15(5-7-16)11-18(13-25)27-22(29)14-26-23(30)21-3-2-10-33-21/h2-10,12,18H,11,14H2,1H3,(H,26,30)(H,27,29)	ZDGBKMDQQXOQBT-UHFFFAOYSA-N	226916	US20260008758, Compound 239	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226916&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963057	336294012							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147927	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CNC(=O)c4cccs4)cc3)cc21	InChI=1S/C24H20N4O4S/c1-28-19-12-17(8-9-20(19)32-24(28)31)16-6-4-15(5-7-16)11-18(13-25)27-22(29)14-26-23(30)21-3-2-10-33-21/h2-10,12,18H,11,14H2,1H3,(H,26,30)(H,27,29)	ZDGBKMDQQXOQBT-UHFFFAOYSA-N	226916	US20260008758, Compound 239	Dipeptidyl peptidase 1	Mus musculus		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226916&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963057	336294012							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147928	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CNC(=O)c4ccco4)cc3)cc21	InChI=1S/C24H20N4O5/c1-28-19-12-17(8-9-20(19)33-24(28)31)16-6-4-15(5-7-16)11-18(13-25)27-22(29)14-26-23(30)21-3-2-10-32-21/h2-10,12,18H,11,14H2,1H3,(H,26,30)(H,27,29)	ZVPTVNVXRMRKSD-UHFFFAOYSA-N	226917	US20260008758, Compound 240	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226917&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963058	336294013							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147929	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CNC(=O)c4ccco4)cc3)cc21	InChI=1S/C24H20N4O5/c1-28-19-12-17(8-9-20(19)33-24(28)31)16-6-4-15(5-7-16)11-18(13-25)27-22(29)14-26-23(30)21-3-2-10-32-21/h2-10,12,18H,11,14H2,1H3,(H,26,30)(H,27,29)	ZVPTVNVXRMRKSD-UHFFFAOYSA-N	226917	US20260008758, Compound 240	Dipeptidyl peptidase 1	Mus musculus		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226917&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963058	336294013							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147930	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCC#N)cc3)cc21	InChI=1S/C21H18N4O3/c1-25-18-12-16(8-9-19(18)28-21(25)27)15-6-4-14(5-7-15)11-17(13-23)24-20(26)3-2-10-22/h4-9,12,17H,2-3,11H2,1H3,(H,24,26)	ZPXWNOWAVPSLGP-UHFFFAOYSA-N	226918	US20260008758, Compound 241	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226918&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963059	336294014							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
147931	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCC#N)cc3)cc21	InChI=1S/C21H18N4O3/c1-25-18-12-16(8-9-19(18)28-21(25)27)15-6-4-14(5-7-15)11-17(13-23)24-20(26)3-2-10-22/h4-9,12,17H,2-3,11H2,1H3,(H,24,26)	ZPXWNOWAVPSLGP-UHFFFAOYSA-N	226918	US20260008758, Compound 241	Dipeptidyl peptidase 1	Mus musculus		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226918&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963059	336294014							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149063	CC(O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C20H19N3O4/c1-12(24)19(25)22-16(11-21)9-13-3-5-14(6-4-13)15-7-8-18-17(10-15)23(2)20(26)27-18/h3-8,10,12,16,24H,9H2,1-2H3,(H,22,25)	ZOZPTDYLQOTFBB-UHFFFAOYSA-N	226919	US20260008758, Compound 242	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226919&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963060	336294015							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149064	CC(O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C20H19N3O4/c1-12(24)19(25)22-16(11-21)9-13-3-5-14(6-4-13)15-7-8-18-17(10-15)23(2)20(26)27-18/h3-8,10,12,16,24H,9H2,1-2H3,(H,22,25)	ZOZPTDYLQOTFBB-UHFFFAOYSA-N	226919	US20260008758, Compound 242	Dipeptidyl peptidase 1	Mus musculus		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226919&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963060	336294015							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149065	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)COC(=O)c4ccco4)cc3)cc21	InChI=1S/C24H19N3O6/c1-27-19-12-17(8-9-20(19)33-24(27)30)16-6-4-15(5-7-16)11-18(13-25)26-22(28)14-32-23(29)21-3-2-10-31-21/h2-10,12,18H,11,14H2,1H3,(H,26,28)	BPJHEUGRFZDMEG-UHFFFAOYSA-N	226920	US20260008758, Compound 243	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226920&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963061	336294016							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149066	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)COC(=O)c4ccco4)cc3)cc21	InChI=1S/C24H19N3O6/c1-27-19-12-17(8-9-20(19)33-24(27)30)16-6-4-15(5-7-16)11-18(13-25)26-22(28)14-32-23(29)21-3-2-10-31-21/h2-10,12,18H,11,14H2,1H3,(H,26,28)	BPJHEUGRFZDMEG-UHFFFAOYSA-N	226920	US20260008758, Compound 243	Dipeptidyl peptidase 1	Mus musculus		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226920&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963061	336294016							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149067	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCOC(=O)c4cccs4)cc3)cc21	InChI=1S/C25H21N3O5S/c1-28-20-14-18(8-9-21(20)33-25(28)31)17-6-4-16(5-7-17)13-19(15-26)27-23(29)10-11-32-24(30)22-3-2-12-34-22/h2-9,12,14,19H,10-11,13H2,1H3,(H,27,29)	IHZHZBPDLACIGS-UHFFFAOYSA-N	226921	US20260008758, Compound 244	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226921&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963062	336294017							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149068	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CCOC(=O)c4cccs4)cc3)cc21	InChI=1S/C25H21N3O5S/c1-28-20-14-18(8-9-21(20)33-25(28)31)17-6-4-16(5-7-17)13-19(15-26)27-23(29)10-11-32-24(30)22-3-2-12-34-22/h2-9,12,14,19H,10-11,13H2,1H3,(H,27,29)	IHZHZBPDLACIGS-UHFFFAOYSA-N	226921	US20260008758, Compound 244	Dipeptidyl peptidase 1	Mus musculus		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226921&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963062	336294017							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149069	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)COC(=O)c4cccs4)cc3)cc21	InChI=1S/C24H19N3O5S/c1-27-19-12-17(8-9-20(19)32-24(27)30)16-6-4-15(5-7-16)11-18(13-25)26-22(28)14-31-23(29)21-3-2-10-33-21/h2-10,12,18H,11,14H2,1H3,(H,26,28)	QPVUVYBGVSBSER-UHFFFAOYSA-N	226922	US20260008758, Compound 245	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226922&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963063	336294018							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149070	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)COC(=O)c4cccs4)cc3)cc21	InChI=1S/C24H19N3O5S/c1-27-19-12-17(8-9-20(19)32-24(27)30)16-6-4-15(5-7-16)11-18(13-25)26-22(28)14-31-23(29)21-3-2-10-33-21/h2-10,12,18H,11,14H2,1H3,(H,26,28)	QPVUVYBGVSBSER-UHFFFAOYSA-N	226922	US20260008758, Compound 245	Dipeptidyl peptidase 1	Mus musculus		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226922&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963063	336294018							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149071	N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3(N)CCOCC3)c(I)c2)cc1	InChI=1S/C22H21IN4O2/c23-20-12-17(16-3-1-15(13-24)2-4-16)5-6-18(20)11-19(14-25)27-21(28)22(26)7-9-29-10-8-22/h1-6,12,19H,7-11,26H2,(H,27,28)	KUHLELIUOFJUKL-UHFFFAOYSA-N	226923	US20260008758, Compound 248	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226923&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963064	336294019							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149072	N#Cc1ccc(-c2ccc(C[C@@H](C#N)NC(=O)C3(N)CCOCC3)c(I)c2)cc1	InChI=1S/C22H21IN4O2/c23-20-12-17(16-3-1-15(13-24)2-4-16)5-6-18(20)11-19(14-25)27-21(28)22(26)7-9-29-10-8-22/h1-6,12,19H,7-11,26H2,(H,27,28)	KUHLELIUOFJUKL-UHFFFAOYSA-N	226923	US20260008758, Compound 248	Dipeptidyl peptidase 1	Mus musculus		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226923&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963064	336294019							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149073	N#Cc1ccc(-c2ccc(C[C@H](C#N)NC(=O)C3(N)CCOCC3)c(I)c2)cc1	InChI=1S/C22H21IN4O2/c23-20-12-17(16-3-1-15(13-24)2-4-16)5-6-18(20)11-19(14-25)27-21(28)22(26)7-9-29-10-8-22/h1-6,12,19H,7-11,26H2,(H,27,28)	KUHLELIUOFJUKL-UHFFFAOYSA-N	226924	US20260008758, Compound 249	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226924&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963065	336294020							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149074	Cn1ccc(CC(N)C(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)c1	InChI=1S/C25H25N5O3/c1-29-10-9-17(15-29)12-21(27)24(31)28-20(14-26)11-16-3-5-18(6-4-16)19-7-8-23-22(13-19)30(2)25(32)33-23/h3-10,13,15,20-21H,11-12,27H2,1-2H3,(H,28,31)	SLKNXEXBKMELDX-UHFFFAOYSA-N	226925	US20260008758, Compound 254	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226925&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963066	336294021							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149075	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3c(n2)CCCN3)cc1F	InChI=1S/C22H26FN5O2/c1-28(2)13-21(29)22(30)26-16(12-24)10-14-5-6-15(11-17(14)23)18-7-8-19-20(27-18)4-3-9-25-19/h5-8,11,16,21,25,29H,3-4,9-10,13H2,1-2H3,(H,26,30)	AEVFOOKJLNPHEV-UHFFFAOYSA-N	226926	US20260008758, Compound 276	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226926&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963043	336294022							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149076	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1cc2c(cc1F)-c1ccc(C#N)cc1CO2	InChI=1S/C22H21FN4O3/c1-27(2)11-20(28)22(29)26-16(10-25)6-14-7-21-18(8-19(14)23)17-4-3-13(9-24)5-15(17)12-30-21/h3-5,7-8,16,20,28H,6,11-12H2,1-2H3,(H,26,29)	UXPVFQJDGXSWRY-UHFFFAOYSA-N	226927	US20260008758, Compound 277A	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226927&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			121297534	336294023							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149077	CN(C)C[C@H](O)C(=O)N[C@@H](C#N)Cc1cc2c(cc1F)-c1ccc(C#N)cc1CO2	InChI=1S/C22H21FN4O3/c1-27(2)11-20(28)22(29)26-16(10-25)6-14-7-21-18(8-19(14)23)17-4-3-13(9-24)5-15(17)12-30-21/h3-5,7-8,16,20,28H,6,11-12H2,1-2H3,(H,26,29)	UXPVFQJDGXSWRY-UHFFFAOYSA-N	226928	US20260008758, Compound 277B	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226928&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963067	336294024							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149078	CCN1C(=O)Cc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@](C)(N)C4CCCC4)c(F)c3)cc21	InChI=1S/C27H31FN4O2/c1-3-32-24-14-18(9-11-20(24)15-25(32)33)17-8-10-19(23(28)13-17)12-22(16-29)31-26(34)27(2,30)21-6-4-5-7-21/h8-11,13-14,21-22H,3-7,12,15,30H2,1-2H3,(H,31,34)	BEFXKIBOKKQEKB-UHFFFAOYSA-N	226929	US20260008758, Compound 264A	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226929&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963068	336294025							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149079	CCN1C(=O)Cc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@](C)(N)C4CCCC4)c(F)c3)cc21	InChI=1S/C27H31FN4O2/c1-3-32-24-14-18(9-11-20(24)15-25(32)33)17-8-10-19(23(28)13-17)12-22(16-29)31-26(34)27(2,30)21-6-4-5-7-21/h8-11,13-14,21-22H,3-7,12,15,30H2,1-2H3,(H,31,34)	BEFXKIBOKKQEKB-UHFFFAOYSA-N	226930	US20260008758, Compound 264B	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226930&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963069	336294026							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149080	CCCCOCCn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(N)C4CCC4)c(F)c3)cc21	InChI=1S/C29H35FN4O4/c1-3-4-13-37-14-12-34-25-17-20(10-11-26(25)38-28(34)36)19-8-9-21(24(30)16-19)15-23(18-31)33-27(35)29(2,32)22-6-5-7-22/h8-11,16-17,22-23H,3-7,12-15,32H2,1-2H3,(H,33,35)	OLWSFDTWVZOIJB-UHFFFAOYSA-N	226931	US20260008758, Compound 267	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226931&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963070	336294027							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149081	CN(C)CCn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(C)(N)C4CCC4)c(F)c3)cc21	InChI=1S/C27H32FN5O3/c1-27(30,20-5-4-6-20)25(34)31-21(16-29)13-19-8-7-17(14-22(19)28)18-9-10-24-23(15-18)33(26(35)36-24)12-11-32(2)3/h7-10,14-15,20-21H,4-6,11-13,30H2,1-3H3,(H,31,34)	VHVDNWVMJRBWPA-UHFFFAOYSA-N	226932	US20260008758, Compound 268	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226932&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963071	336294028							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149082	CN1CCC2(CCc3ccc(-c4ccc(C[C@@H](C#N)NC(=O)C(C)(N)C5CCC5)c(F)c4)cc32)CC1	InChI=1S/C30H37FN4O/c1-29(33,24-4-3-5-24)28(36)34-25(19-32)16-23-9-8-22(18-27(23)31)21-7-6-20-10-11-30(26(20)17-21)12-14-35(2)15-13-30/h6-9,17-18,24-25H,3-5,10-16,33H2,1-2H3,(H,34,36)	ODCCBXZVQJANEY-UHFFFAOYSA-N	226933	US20260008758, Compound 269	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226933&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963072	336294029							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149083	CN1CCN[C@@H](CC(=O)N[C@H](C#N)Cc2ccc(-c3ccc4oc(=O)n(C)c4c3)cc2)C1	InChI=1S/C24H27N5O3/c1-28-10-9-26-20(15-28)13-23(30)27-19(14-25)11-16-3-5-17(6-4-16)18-7-8-22-21(12-18)29(2)24(31)32-22/h3-8,12,19-20,26H,9-11,13,15H2,1-2H3,(H,27,30)	YYJKMXTXFNQFRG-UHFFFAOYSA-N	226934	US20260008758, Compound 253	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226934&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963073	336294030							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149084	C[C@@H](NCc1cccs1)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C25H24N4O3S/c1-16(27-15-21-4-3-11-33-21)24(30)28-20(14-26)12-17-5-7-18(8-6-17)19-9-10-23-22(13-19)29(2)25(31)32-23/h3-11,13,16,20,27H,12,15H2,1-2H3,(H,28,30)	APVQBVXZWGLOTO-UHFFFAOYSA-N	226935	US20260008758, Compound 232	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226935&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963074	336294031							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149085	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@@H](N)Cc4cccc(O)c4)cc3)cc21	InChI=1S/C27H26N4O4/c1-31-24-14-20(9-10-25(24)35-27(31)34)19-7-5-17(6-8-19)12-22(16-28)30-26(33)15-21(29)11-18-3-2-4-23(32)13-18/h2-10,13-14,21-22,32H,11-12,15,29H2,1H3,(H,30,33)	QIUGULIIXRIXIF-UHFFFAOYSA-N	226936	US20260008758, Compound 225	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226936&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963075	336294032							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149086	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@@H](N)C4CCCO4)cc3)cc21	InChI=1S/C24H26N4O4/c1-28-20-12-17(8-9-22(20)32-24(28)30)16-6-4-15(5-7-16)11-18(14-25)27-23(29)13-19(26)21-3-2-10-31-21/h4-9,12,18-19,21H,2-3,10-11,13,26H2,1H3,(H,27,29)	CAGOYLOVWSIJPH-UHFFFAOYSA-N	226937	US20260008758, Compound 226	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226937&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963076	336294033							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149087	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)Cc4ccccc4O)cc3)cc21	InChI=1S/C27H26N4O4/c1-31-23-14-19(10-11-25(23)35-27(31)34)18-8-6-17(7-9-18)12-22(16-28)30-26(33)15-21(29)13-20-4-2-3-5-24(20)32/h2-11,14,21-22,32H,12-13,15,29H2,1H3,(H,30,33)	DXBQXNKCRVNVJN-UHFFFAOYSA-N	226938	US20260008758, Compound 228	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226938&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963077	336294034							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149088	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)CC(N)Cc4cocn4)cc3)cc21	InChI=1S/C24H23N5O4/c1-29-21-9-17(6-7-22(21)33-24(29)31)16-4-2-15(3-5-16)8-19(12-25)28-23(30)11-18(26)10-20-13-32-14-27-20/h2-7,9,13-14,18-19H,8,10-11,26H2,1H3,(H,28,30)	XCMTXEOJZRKSID-UHFFFAOYSA-N	226939	US20260008758, Compound 230	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226939&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963078	336294035							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149089	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C(N)Cc4ccon4)cc3)cc21	InChI=1S/C23H21N5O4/c1-28-20-11-16(6-7-21(20)32-23(28)30)15-4-2-14(3-5-15)10-18(13-24)26-22(29)19(25)12-17-8-9-31-27-17/h2-9,11,18-19H,10,12,25H2,1H3,(H,26,29)	QPHKGBTVABAUAQ-UHFFFAOYSA-N	226940	US20260008758, Compound 231	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226940&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963079	336294036							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149090	C[C@@H](O)[C@](C)(N)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-13(27)22(2,24)20(28)25-17(12-23)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)26(3)21(29)30-19/h4-9,11,13,17,27H,10,24H2,1-3H3,(H,25,28)	KWOQYTPEJYUKRE-UHFFFAOYSA-N	226941	US20260008758, Compound 171A	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226941&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963080	336294037							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149091	C[C@H](O)[C@](C)(N)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-13(27)22(2,24)20(28)25-17(12-23)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)26(3)21(29)30-19/h4-9,11,13,17,27H,10,24H2,1-3H3,(H,25,28)	KWOQYTPEJYUKRE-UHFFFAOYSA-N	226942	US20260008758, Compound 171B	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226942&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963081	336294038							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149092	C[C@@H](O)[C@@](C)(N)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-13(27)22(2,24)20(28)25-17(12-23)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)26(3)21(29)30-19/h4-9,11,13,17,27H,10,24H2,1-3H3,(H,25,28)	KWOQYTPEJYUKRE-UHFFFAOYSA-N	226943	US20260008758, Compound 171C	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226943&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963082	336294039							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149093	C[C@H](O)[C@@](C)(N)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-13(27)22(2,24)20(28)25-17(12-23)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)26(3)21(29)30-19/h4-9,11,13,17,27H,10,24H2,1-3H3,(H,25,28)	KWOQYTPEJYUKRE-UHFFFAOYSA-N	226944	US20260008758, Compound 171D	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226944&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963083	336294040							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149094	C[C@H](O)[C@@](C)(N)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C22H24N4O4/c1-13(27)22(2,24)20(28)25-17(12-23)10-14-4-6-15(7-5-14)16-8-9-19-18(11-16)26(3)21(29)30-19/h4-9,11,13,17,27H,10,24H2,1-3H3,(H,25,28)	KWOQYTPEJYUKRE-UHFFFAOYSA-N	226944	US20260008758, Compound 171D	Dipeptidyl peptidase 1	Mus musculus		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002105&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226944&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963083	336294040							1	MGPWTHSLRAVLLLVLLGVCTVRSDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHTAISYCHETMTGWVHDVLGRNWACFVGKKVESHIEKVNMNAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSLRDLIRRSGHSQRIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKPRENCLRYYSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHHTGLSDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESIAVAAIPIPKL		Dipeptidyl peptidase 1	CATC_MOUSE	P97821	O08853																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149095	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@H](N)c4ccccc4O)cc3)cc21	InChI=1S/C26H24N4O4/c1-30-22-13-18(10-11-24(22)34-26(30)33)17-8-6-16(7-9-17)12-19(15-27)29-25(32)14-21(28)20-4-2-3-5-23(20)31/h2-11,13,19,21,31H,12,14,28H2,1H3,(H,29,32)	ZKQZTDDQYICALR-UHFFFAOYSA-N	226945	US20260008758, Compound 227A	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226945&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963084	336294041							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149096	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C[C@@H](N)c4ccccc4O)cc3)cc21	InChI=1S/C26H24N4O4/c1-30-22-13-18(10-11-24(22)34-26(30)33)17-8-6-16(7-9-17)12-19(15-27)29-25(32)14-21(28)20-4-2-3-5-23(20)31/h2-11,13,19,21,31H,12,14,28H2,1H3,(H,29,32)	ZKQZTDDQYICALR-UHFFFAOYSA-N	226946	US20260008758, Compound 227B	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226946&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963085	336294042							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149097	NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r|	InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)	NNUFRZJZOXVZIT-UHFFFAOYSA-N	50011502	CHEMBL3261926::US20260008758, Compound 246	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011502&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			49783666	103924055		CHEMBL3261926					1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149098	CC(C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1)C1(N)CC1	InChI=1S/C23H24N4O3/c1-14(23(25)9-10-23)21(28)26-18(13-24)11-15-3-5-16(6-4-15)17-7-8-20-19(12-17)27(2)22(29)30-20/h3-8,12,14,18H,9-11,25H2,1-2H3,(H,26,28)	MVAOHDATGHAYLP-UHFFFAOYSA-N	226948	US20260008758, Compound 195	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226948&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963087	336294044							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149099	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](O)CN4CCCC4)cc3)cc21	InChI=1S/C24H26N4O4/c1-27-20-13-18(8-9-22(20)32-24(27)31)17-6-4-16(5-7-17)12-19(14-25)26-23(30)21(29)15-28-10-2-3-11-28/h4-9,13,19,21,29H,2-3,10-12,15H2,1H3,(H,26,30)	ATZRDTXMDOXDFF-UHFFFAOYSA-N	226949	US20260008758, Compound 120	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226949&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963088	336294045							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149100	CCN(C)C[C@H](OC)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C24H28N4O4/c1-5-27(2)15-22(31-4)23(29)26-19(14-25)12-16-6-8-17(9-7-16)18-10-11-21-20(13-18)28(3)24(30)32-21/h6-11,13,19,22H,5,12,15H2,1-4H3,(H,26,29)	XTINKVAZLPEPPS-UHFFFAOYSA-N	226950	US20260008758, Compound 130	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226950&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963089	336294046							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149101	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3nnn(C)c3c2)cc1F	InChI=1S/C21H23FN6O2/c1-27(2)12-20(29)21(30)24-16(11-23)8-15-5-4-13(9-17(15)22)14-6-7-18-19(10-14)28(3)26-25-18/h4-7,9-10,16,20,29H,8,12H2,1-3H3,(H,24,30)	XJZWAWIBBMHSCC-UHFFFAOYSA-N	226951	US20260008758, Compound 141	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226951&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963090	336294047							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149102	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(CCN4CCOCC4)c3c2)cc1F	InChI=1S/C27H32FN5O5/c1-31(2)17-24(34)26(35)30-21(16-29)13-20-4-3-18(14-22(20)28)19-5-6-25-23(15-19)33(27(36)38-25)8-7-32-9-11-37-12-10-32/h3-6,14-15,21,24,34H,7-13,17H2,1-2H3,(H,30,35)	ZXKVYSNZKFCWLP-UHFFFAOYSA-N	226952	US20260008758, Compound 142	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226952&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963091	336294048							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149103	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3c(c2)C2(CCN(C4COC4)CC2)OC3)cc1	InChI=1S/C29H36N4O4/c1-32(2)16-27(34)28(35)31-24(15-30)13-20-3-5-21(6-4-20)22-7-8-23-17-37-29(26(23)14-22)9-11-33(12-10-29)25-18-36-19-25/h3-8,14,24-25,27,34H,9-13,16-19H2,1-2H3,(H,31,35)	VEZLDWOYLUPKQV-UHFFFAOYSA-N	226953	US20260008758, Compound 144	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226953&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963092	336294049							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149104	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3c(c2)C2(CCCN(C)C2)C(=O)N3C)cc1	InChI=1S/C28H35N5O3/c1-31(2)17-25(34)26(35)30-22(16-29)14-19-6-8-20(9-7-19)21-10-11-24-23(15-21)28(27(36)33(24)4)12-5-13-32(3)18-28/h6-11,15,22,25,34H,5,12-14,17-18H2,1-4H3,(H,30,35)	WYIZJGUUGITJSR-UHFFFAOYSA-N	226954	US20260008758, Compound 145	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226954&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963093	336294050							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149105	CCCCOCCn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H](O)CN(C)C)c(F)c3)cc21	InChI=1S/C27H33FN4O5/c1-4-5-11-36-12-10-32-23-15-19(8-9-25(23)37-27(32)35)18-6-7-20(22(28)14-18)13-21(16-29)30-26(34)24(33)17-31(2)3/h6-9,14-15,21,24,33H,4-5,10-13,17H2,1-3H3,(H,30,34)	PHAVWQMSVIIIDK-UHFFFAOYSA-N	226955	US20260008758, Compound 146	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226955&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963094	336294051							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149106	Cc1ccccc1C[C@H](CN)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C28H28N4O3/c1-18-5-3-4-6-21(18)14-23(16-29)27(33)31-24(17-30)13-19-7-9-20(10-8-19)22-11-12-26-25(15-22)32(2)28(34)35-26/h3-12,15,23-24H,13-14,16,29H2,1-2H3,(H,31,33)	YENUPTWEPIHPBC-UHFFFAOYSA-N	226956	US20260008758, Compound 193	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226956&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963095	336294052							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149107	Cc1ccccc1C[C@@H](CN)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C28H28N4O3/c1-18-5-3-4-6-21(18)14-23(16-29)27(33)31-24(17-30)13-19-7-9-20(10-8-19)22-11-12-26-25(15-22)32(2)28(34)35-26/h3-12,15,23-24H,13-14,16,29H2,1-2H3,(H,31,33)	YENUPTWEPIHPBC-UHFFFAOYSA-N	226957	US20260008758, Compound 194	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226957&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963096	336294053							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149108	CN(C)C[C@H](F)C(=O)N[C@H](C#N)Cc1cc2c(cc1F)-c1ccc(C#N)cc1CO2	InChI=1S/C22H20F2N4O2/c1-28(2)11-20(24)22(29)27-16(10-26)6-14-7-21-18(8-19(14)23)17-4-3-13(9-25)5-15(17)12-30-21/h3-5,7-8,16,20H,6,11-12H2,1-2H3,(H,27,29)	PBEPBPGXTYEABN-UHFFFAOYSA-N	226958	US20260008758, Compound 278	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226958&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963097	336294054							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149109	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3c(c2)C(C2CCN(C4COC4)CC2)OC3)cc1	InChI=1S/C30H38N4O4/c1-33(2)16-28(35)30(36)32-25(15-31)13-20-3-5-21(6-4-20)23-7-8-24-17-38-29(27(24)14-23)22-9-11-34(12-10-22)26-18-37-19-26/h3-8,14,22,25-26,28-29,35H,9-13,16-19H2,1-2H3,(H,32,36)	JWEPXZVDFGCPTM-UHFFFAOYSA-N	226959	US20260008758, Compound 281	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226959&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963098	336294055							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149110	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3cnn(C4CCN(C5COC5)CC4)c3c2)cc1	InChI=1S/C29H36N6O3/c1-33(2)17-28(36)29(37)32-24(15-30)13-20-3-5-21(6-4-20)22-7-8-23-16-31-35(27(23)14-22)25-9-11-34(12-10-25)26-18-38-19-26/h3-8,14,16,24-26,28,36H,9-13,17-19H2,1-2H3,(H,32,37)	PTFCCIDWLKVZJY-UHFFFAOYSA-N	226960	US20260008758, Compound 282	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226960&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963099	336294056							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149111	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3c(c2)C2(CCN(C4COC4)CC2)OC3)cc1F	InChI=1S/C29H35FN4O4/c1-33(2)15-27(35)28(36)32-23(14-31)11-21-5-3-20(13-26(21)30)19-4-6-22-16-38-29(25(22)12-19)7-9-34(10-8-29)24-17-37-18-24/h3-6,12-13,23-24,27,35H,7-11,15-18H2,1-2H3,(H,32,36)	PTPSHXDNUCLKPA-UHFFFAOYSA-N	226961	US20260008758, Compound 283	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226961&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963100	336294057							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149112	CO[C@@H](CN(C)C)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3c(c2)C2(CCN(C4COC4)CC2)OC3)cc1F	InChI=1S/C30H37FN4O4/c1-34(2)16-28(37-3)29(36)33-24(15-32)12-22-6-4-21(14-27(22)31)20-5-7-23-17-39-30(26(23)13-20)8-10-35(11-9-30)25-18-38-19-25/h4-7,13-14,24-25,28H,8-12,16-19H2,1-3H3,(H,33,36)	VPMOTRIGKWLXTE-UHFFFAOYSA-N	226962	US20260008758, Compound 284	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226962&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963101	336294058							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149113	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3cnn(C4CCN(C)CC4)c3c2)cc1F	InChI=1S/C27H33FN6O2/c1-32(2)17-26(35)27(36)31-22(15-29)12-20-6-4-18(13-24(20)28)19-5-7-21-16-30-34(25(21)14-19)23-8-10-33(3)11-9-23/h4-7,13-14,16,22-23,26,35H,8-12,17H2,1-3H3,(H,31,36)	VIMUVMFZENEGGS-UHFFFAOYSA-N	226963	US20260008758, Compound 285	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226963&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963102	336294059							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149114	CO[C@@H](CN(C)C)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3cnn(C4CCN(C)CC4)c3c2)cc1F	InChI=1S/C28H35FN6O2/c1-33(2)18-27(37-4)28(36)32-23(16-30)13-21-7-5-19(14-25(21)29)20-6-8-22-17-31-35(26(22)15-20)24-9-11-34(3)12-10-24/h5-8,14-15,17,23-24,27H,9-13,18H2,1-4H3,(H,32,36)	JUXCGEWOZCKWGK-UHFFFAOYSA-N	226964	US20260008758, Compound 286	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226964&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963103	336294060							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149115	CN(C)C[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3cnn(C4CCN(C5COC5)CC4)c3c2)cc1F	InChI=1S/C29H35FN6O3/c1-34(2)16-28(37)29(38)33-23(14-31)11-21-5-3-19(12-26(21)30)20-4-6-22-15-32-36(27(22)13-20)24-7-9-35(10-8-24)25-17-39-18-25/h3-6,12-13,15,23-25,28,37H,7-11,16-18H2,1-2H3,(H,33,38)	CIUXVCZZQRVZBO-UHFFFAOYSA-N	226965	US20260008758, Compound 287	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226965&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963104	336294061							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149116	CO[C@@H](CN(C)C)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3cnn(C4CCN(C5COC5)CC4)c3c2)cc1F	InChI=1S/C30H37FN6O3/c1-35(2)17-29(39-3)30(38)34-24(15-32)12-22-6-4-20(13-27(22)31)21-5-7-23-16-33-37(28(23)14-21)25-8-10-36(11-9-25)26-18-40-19-26/h4-7,13-14,16,24-26,29H,8-12,17-19H2,1-3H3,(H,34,38)	JZOLGGJDVGOCIO-UHFFFAOYSA-N	226966	US20260008758, Compound 288	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226966&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963105	336294062							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149117	C[C@@H](N)[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O4/c1-12(23)19(26)20(27)24-16(11-22)9-13-3-5-14(6-4-13)15-7-8-18-17(10-15)25(2)21(28)29-18/h3-8,10,12,16,19,26H,9,23H2,1-2H3,(H,24,27)	QLKZVKVGIFBLON-UHFFFAOYSA-N	226967	US20260008758, Compound 102A	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226967&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963106	336294063							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149118	C[C@@H](N)[C@@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O4/c1-12(23)19(26)20(27)24-16(11-22)9-13-3-5-14(6-4-13)15-7-8-18-17(10-15)25(2)21(28)29-18/h3-8,10,12,16,19,26H,9,23H2,1-2H3,(H,24,27)	QLKZVKVGIFBLON-UHFFFAOYSA-N	226968	US20260008758, Compound 102B	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226968&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963107	336294064							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149119	C[C@H](N)[C@H](O)C(=O)N[C@H](C#N)Cc1ccc(-c2ccc3oc(=O)n(C)c3c2)cc1	InChI=1S/C21H22N4O4/c1-12(23)19(26)20(27)24-16(11-22)9-13-3-5-14(6-4-13)15-7-8-18-17(10-15)25(2)21(28)29-18/h3-8,10,12,16,19,26H,9,23H2,1-2H3,(H,24,27)	QLKZVKVGIFBLON-UHFFFAOYSA-N	226969	US20260008758, Compound 102C	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226969&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963108	336294065							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149120	COCCN(C)CCn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@](C)(N)C4CCCC4)cc3)cc21	InChI=1S/C30H39N5O4/c1-30(32,24-6-4-5-7-24)28(36)33-25(20-31)18-21-8-10-22(11-9-21)23-12-13-27-26(19-23)35(29(37)39-27)15-14-34(2)16-17-38-3/h8-13,19,24-25H,4-7,14-18,32H2,1-3H3,(H,33,36)	YPUMFQOOAWFNAJ-UHFFFAOYSA-N	226970	US20260008758, Compound 258A	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226970&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963109	336294066							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149121	COCCN(C)CCn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@](C)(N)C4CCCC4)cc3)cc21	InChI=1S/C30H39N5O4/c1-30(32,24-6-4-5-7-24)28(36)33-25(20-31)18-21-8-10-22(11-9-21)23-12-13-27-26(19-23)35(29(37)39-27)15-14-34(2)16-17-38-3/h8-13,19,24-25H,4-7,14-18,32H2,1-3H3,(H,33,36)	YPUMFQOOAWFNAJ-UHFFFAOYSA-N	226971	US20260008758, Compound 258B	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226971&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963110	336294067							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149122	CCN1C(=O)Cc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@](C)(N)C4CCCC4)cc3)cc21	InChI=1S/C27H32N4O2/c1-3-31-24-15-20(12-13-21(24)16-25(31)32)19-10-8-18(9-11-19)14-23(17-28)30-26(33)27(2,29)22-6-4-5-7-22/h8-13,15,22-23H,3-7,14,16,29H2,1-2H3,(H,30,33)	UTTQMBMHMCIRHC-UHFFFAOYSA-N	226972	US20260008758, Compound 259A	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226972&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963111	336294068							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149123	CCN1C(=O)Cc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@](C)(N)C4CCCC4)cc3)cc21	InChI=1S/C27H32N4O2/c1-3-31-24-15-20(12-13-21(24)16-25(31)32)19-10-8-18(9-11-19)14-23(17-28)30-26(33)27(2,29)22-6-4-5-7-22/h8-13,15,22-23H,3-7,14,16,29H2,1-2H3,(H,30,33)	UTTQMBMHMCIRHC-UHFFFAOYSA-N	226973	US20260008758, Compound 259B	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226973&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963112	336294069							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149124	Cc1cn2cc(-c3ccc(C[C@@H](C#N)NC(=O)[C@](C)(N)C4CCC4)c(F)c3)cc2c(C)n1	InChI=1S/C25H28FN5O/c1-15-13-31-14-19(11-23(31)16(2)29-15)17-7-8-18(22(26)10-17)9-21(12-27)30-24(32)25(3,28)20-5-4-6-20/h7-8,10-11,13-14,20-21H,4-6,9,28H2,1-3H3,(H,30,32)	CYZCZCFLOZRLDV-UHFFFAOYSA-N	226974	US20260008758, Compound 272A	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226974&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963113	336294070							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149125	Cc1cn2cc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@](C)(N)C4CCC4)c(F)c3)cc2c(C)n1	InChI=1S/C25H28FN5O/c1-15-13-31-14-19(11-23(31)16(2)29-15)17-7-8-18(22(26)10-17)9-21(12-27)30-24(32)25(3,28)20-5-4-6-20/h7-8,10-11,13-14,20-21H,4-6,9,28H2,1-3H3,(H,30,32)	CYZCZCFLOZRLDV-UHFFFAOYSA-N	226975	US20260008758, Compound 272B	Dipeptidyl peptidase 1	Homo sapiens		 10							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226975&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963114	336294071							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149126	COCCN(C)CCn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@](C)(N)C4CCC4)c(F)c3)cc21	InChI=1S/C29H36FN5O4/c1-29(32,22-5-4-6-22)27(36)33-23(18-31)15-21-8-7-19(16-24(21)30)20-9-10-26-25(17-20)35(28(37)39-26)12-11-34(2)13-14-38-3/h7-10,16-17,22-23H,4-6,11-15,32H2,1-3H3,(H,33,36)	NPDSXOMBPMSMGA-UHFFFAOYSA-N	226976	US20260008758, Compound 270A	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226976&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963113	336294072							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149127	COCCN(C)CCn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@](C)(N)C4CCC4)c(F)c3)cc21	InChI=1S/C29H36FN5O4/c1-29(32,22-5-4-6-22)27(36)33-23(18-31)15-21-8-7-19(16-24(21)30)20-9-10-26-25(17-20)35(28(37)39-26)12-11-34(2)13-14-38-3/h7-10,16-17,22-23H,4-6,11-15,32H2,1-3H3,(H,33,36)	NPDSXOMBPMSMGA-UHFFFAOYSA-N	226977	US20260008758, Compound 270B	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226977&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963115	336294073							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149128	Cn1c(=O)oc2ccc(-c3ccc(C[C@H](C#N)NC(=O)C4(N)CCCC45CC5)c(F)c3)cc21	InChI=1S/C25H25FN4O3/c1-30-20-13-16(5-6-21(20)33-23(30)32)15-3-4-17(19(26)12-15)11-18(14-27)29-22(31)25(28)8-2-7-24(25)9-10-24/h3-6,12-13,18H,2,7-11,28H2,1H3,(H,29,31)	JBXUYOBSWNCSHB-UHFFFAOYSA-N	226978	US20260008758, Compound 273A	Dipeptidyl peptidase 1	Homo sapiens		>15							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226978&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963116	336294074							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149129	Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(N)CCCC45CC5)c(F)c3)cc21	InChI=1S/C25H25FN4O3/c1-30-20-13-16(5-6-21(20)33-23(30)32)15-3-4-17(19(26)12-15)11-18(14-27)29-22(31)25(28)8-2-7-24(25)9-10-24/h3-6,12-13,18H,2,7-11,28H2,1H3,(H,29,31)	JBXUYOBSWNCSHB-UHFFFAOYSA-N	226979	US20260008758, Compound 273B	Dipeptidyl peptidase 1	Homo sapiens		<5							US Patent		10.7270/Q270868W			US20260008758	PLAUNT, AJ; GOBBO, G; KIM, B; SHI, Y	1/8/2026	5/21/2026	Insmed	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6578&target=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226979&enzyme=Dipeptidyl+peptidase+1&column=ki&startPg=0&Increment=50&submit=Search			126963117	336294075							1	MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL	4OEM,4OEL,6RNI,4CDF,6RNE,6RN9,6RN7,6IC6,4CDE,4CDD,4CDC,2DJG,2DJF,1K3B,6RN6,6IC7,6IC5	Dipeptidyl peptidase 1	CATC_HUMAN	P53634	A8K7V2 B5MDD5 Q2HIY8 Q53G93 Q71E75 Q71E76 Q7M4N9 Q7Z3G7 Q7Z5U7 Q8WY99 Q8WYA7 Q8WYA8