BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
149130	CC1CC(c2cccc(N3CCc4c(cc(CN5CC[C@H](F)C5)cc4C(F)(F)F)C3=O)c2)(c2nncn2C)C1	InChI=1S/C29H31F4N5O/c1-18-13-28(14-18,27-35-34-17-36(27)2)20-4-3-5-22(12-20)38-9-7-23-24(26(38)39)10-19(11-25(23)29(31,32)33)15-37-8-6-21(30)16-37/h3-5,10-12,17-18,21H,6-9,13-16H2,1-2H3	TTWIHSOCJMMFFD-UHFFFAOYSA-N	226947	US20260008770, Example 1	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226947&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963086	336294043							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149131	C[C@H]1CCCN(Cc2cc3c(c(C(F)(F)F)c2)CCN(c2cccc([C@]4(c5nncn5C)C[C@@H](C)C4)c2)C3=O)C1	InChI=1S/C31H36F3N5O/c1-20-6-5-10-38(17-20)18-22-12-26-25(27(13-22)31(32,33)34)9-11-39(28(26)40)24-8-4-7-23(14-24)30(15-21(2)16-30)29-36-35-19-37(29)3/h4,7-8,12-14,19-21H,5-6,9-11,15-18H2,1-3H3	PQPUBPMJVGYMCT-UHFFFAOYSA-N	226980	US20260008770, Example 2	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226980&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963118	336294076							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149132	CC1CC(c2cccc(-c3nc4cc(CN5CCC[C@H](C)C5)cc(C(F)(F)F)c4s3)c2)(c2nncn2C)C1	InChI=1S/C29H32F3N5S/c1-18-6-5-9-37(15-18)16-20-10-23(29(30,31)32)25-24(11-20)34-26(38-25)21-7-4-8-22(12-21)28(13-19(2)14-28)27-35-33-17-36(27)3/h4,7-8,10-12,17-19H,5-6,9,13-16H2,1-3H3	SVKMDPUWGYVLJR-UHFFFAOYSA-N	226981	US20260008770, Example 4	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226981&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963119	336294077							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149133	CC1CC(c2cccc(-c3n[nH]c4c(CN5CCC[C@H](C)C5)cc(C(F)(F)F)nc34)c2)(c2nncn2C)C1	InChI=1S/C28H32F3N7/c1-17-6-5-9-38(14-17)15-20-11-22(28(29,30)31)33-25-23(34-35-24(20)25)19-7-4-8-21(10-19)27(12-18(2)13-27)26-36-32-16-37(26)3/h4,7-8,10-11,16-18H,5-6,9,12-15H2,1-3H3,(H,34,35)	ADZZEZFIHDBJMX-UHFFFAOYSA-N	226982	US20260008770, Example 5	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226982&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963120	336294078							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149134	CC1CC(c2cccc(-n3ncc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H33F3N6O/c1-19-6-5-9-38(16-19)17-21-10-24-25(26(11-21)30(31,32)33)15-35-39(27(24)40)23-8-4-7-22(12-23)29(13-20(2)14-29)28-36-34-18-37(28)3/h4,7-8,10-12,15,18-20H,5-6,9,13-14,16-17H2,1-3H3	KLOPCKGKZVLCQU-UHFFFAOYSA-N	226983	US20260008770, Example 6	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226983&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963121	336294079							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149135	CC1CC(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C29H33F3N6/c1-19-6-5-9-37(15-19)16-21-10-25(29(30,31)32)24-17-38(35-26(24)11-21)23-8-4-7-22(12-23)28(13-20(2)14-28)27-34-33-18-36(27)3/h4,7-8,10-12,17-20H,5-6,9,13-16H2,1-3H3	VGHDXASNBPIYQI-UHFFFAOYSA-N	226984	US20260008770, Example 7	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226984&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963122	336294080							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149136	CC1CC(c2cccc(-c3nc4cc(CN5CCC[C@H](C)C5)cc(C(F)(F)F)c4n3C)c2)(c2nncn2C)C1	InChI=1S/C30H35F3N6/c1-19-7-6-10-39(16-19)17-21-11-24(30(31,32)33)26-25(12-21)35-27(38(26)4)22-8-5-9-23(13-22)29(14-20(2)15-29)28-36-34-18-37(28)3/h5,8-9,11-13,18-20H,6-7,10,14-17H2,1-4H3	DTBQROBNDOCQGE-UHFFFAOYSA-N	226985	US20260008770, Example 8	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226985&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963123	336294081							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149137	CC1CC(c2cccc(-n3nc(C(F)(F)F)c4ccc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H33F3N6O/c1-19-6-5-11-38(16-19)17-21-9-10-24-25(12-21)27(40)39(36-26(24)30(31,32)33)23-8-4-7-22(13-23)29(14-20(2)15-29)28-35-34-18-37(28)3/h4,7-10,12-13,18-20H,5-6,11,14-17H2,1-3H3	SWFDTNSXPKMCIN-UHFFFAOYSA-N	226986	US20260008770, Example 9	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226986&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963124	336294082							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149138	CC1CC(c2cccc(-n3ncc4c(C(F)(F)F)cc(CN5CCO[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C29H31F3N6O2/c1-18-12-28(13-18,27-35-33-17-36(27)3)21-5-4-6-22(11-21)38-26(39)23-9-20(16-37-7-8-40-19(2)15-37)10-25(29(30,31)32)24(23)14-34-38/h4-6,9-11,14,17-19H,7-8,12-13,15-16H2,1-3H3	NNLZVZMXKOAIDH-UHFFFAOYSA-N	226987	US20260008770, Example 10	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		>1000							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226987&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963125	336294083							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149139	CC1CC(c2cccc(-c3nc4cc(CN5CCO[C@H](C)C5)cc(C(F)(F)F)c4s3)c2)(c2nncn2C)C1	InChI=1S/C28H30F3N5OS/c1-17-12-27(13-17,26-34-32-16-35(26)3)21-6-4-5-20(11-21)25-33-23-10-19(15-36-7-8-37-18(2)14-36)9-22(24(23)38-25)28(29,30)31/h4-6,9-11,16-18H,7-8,12-15H2,1-3H3	ZTVATTQDHTVLEF-UHFFFAOYSA-N	226988	US20260008770, Example 11	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226988&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963126	336294084							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149140	CC1CC(c2cccc(-n3cc(C(F)(F)F)c4ccc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C31H34F3N5O/c1-20-6-5-11-38(16-20)17-22-9-10-25-26(12-22)28(40)39(18-27(25)31(32,33)34)24-8-4-7-23(13-24)30(14-21(2)15-30)29-36-35-19-37(29)3/h4,7-10,12-13,18-21H,5-6,11,14-17H2,1-3H3	ZARBXSIAQDSGEZ-UHFFFAOYSA-N	226989	US20260008770, Example 12	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226989&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963127	336294085							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149141	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cnn(-c4cccc(C5(Cc6nncn6C)COC5)c4)c(=O)c3c2)C1	InChI=1S/C29H31F3N6O2/c1-19-5-4-8-37(14-19)15-20-9-23-24(25(10-20)29(30,31)32)13-34-38(27(23)39)22-7-3-6-21(11-22)28(16-40-17-28)12-26-35-33-18-36(26)2/h3,6-7,9-11,13,18-19H,4-5,8,12,14-17H2,1-2H3	QNJRIMJMJIVSOQ-UHFFFAOYSA-N	226990	US20260008770, Example 13	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 750							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226990&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963128	336294086							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149142	CC1CC(c2cccc(-n3ncc4c(C(F)(F)F)cc(CN5CCC(F)(F)[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H31F5N6O/c1-18-12-28(13-18,27-38-36-17-39(27)3)21-5-4-6-22(11-21)41-26(42)23-9-20(10-25(30(33,34)35)24(23)14-37-41)16-40-8-7-29(31,32)19(2)15-40/h4-6,9-11,14,17-19H,7-8,12-13,15-16H2,1-3H3	VBPYPKUULDKYNQ-UHFFFAOYSA-N	226991	US20260008770, Example 14	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226991&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963129	336294087							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149143	CC1CC(c2cccc(-n3ncc4c(C(F)(F)F)cc(CN5CCC(F)(F)[C@@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H31F5N6O/c1-18-12-28(13-18,27-38-36-17-39(27)3)21-5-4-6-22(11-21)41-26(42)23-9-20(10-25(30(33,34)35)24(23)14-37-41)16-40-8-7-29(31,32)19(2)15-40/h4-6,9-11,14,17-19H,7-8,12-13,15-16H2,1-3H3	VBPYPKUULDKYNQ-UHFFFAOYSA-N	226992	US20260008770, Example 15	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		>1000							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226992&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963130	336294088							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149144	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3sc(-c4cccc(C5(Cc6nncn6C)COC5)c4)nc3c2)C1	InChI=1S/C28H30F3N5OS/c1-18-5-4-8-36(13-18)14-19-9-22(28(29,30)31)25-23(10-19)33-26(38-25)20-6-3-7-21(11-20)27(15-37-16-27)12-24-34-32-17-35(24)2/h3,6-7,9-11,17-18H,4-5,8,12-16H2,1-2H3	RFRWNYSDQVZEDL-UHFFFAOYSA-N	226993	US20260008770, Example 16	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226993&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963131	336294089							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149145	CC1CC(c2cccc(-c3nc4cc(CN5CCC[C@H](C)C5)cc(C(F)(F)F)c4[nH]3)c2)(c2nncn2C)C1	InChI=1S/C29H33F3N6/c1-18-6-5-9-38(15-18)16-20-10-23(29(30,31)32)25-24(11-20)34-26(35-25)21-7-4-8-22(12-21)28(13-19(2)14-28)27-36-33-17-37(27)3/h4,7-8,10-12,17-19H,5-6,9,13-16H2,1-3H3,(H,34,35)	ZRXOEGMBVWGSAQ-UHFFFAOYSA-N	226994	US20260008770, Example 17	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226994&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963132	336294090							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149146	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cnn(-c4cccc([C@@H](c5nncn5C)C5CCC5)c4)c(=O)c3c2)C1	InChI=1S/C30H33F3N6O/c1-19-6-5-11-38(16-19)17-20-12-24-25(26(13-20)30(31,32)33)15-35-39(29(24)40)23-10-4-9-22(14-23)27(21-7-3-8-21)28-36-34-18-37(28)2/h4,9-10,12-15,18-19,21,27H,3,5-8,11,16-17H2,1-2H3	ZINGCDNHPUPCEW-UHFFFAOYSA-N	226995	US20260008770, Example 18	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		>1000							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226995&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963133	336294091							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149147	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cnn(-c4cccc([C@H](c5nncn5C)C5CCC5)c4)c(=O)c3c2)C1	InChI=1S/C30H33F3N6O/c1-19-6-5-11-38(16-19)17-20-12-24-25(26(13-20)30(31,32)33)15-35-39(29(24)40)23-10-4-9-22(14-23)27(21-7-3-8-21)28-36-34-18-37(28)2/h4,9-10,12-15,18-19,21,27H,3,5-8,11,16-17H2,1-2H3	ZINGCDNHPUPCEW-UHFFFAOYSA-N	226996	US20260008770, Example 19	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226996&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963134	336294092							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149148	C#CC1CCCN(Cc2cc(C(F)(F)F)c3cnn(-c4cccc(C5(c6nncn6C)CC(C)C5)c4)c(=O)c3c2)C1	InChI=1S/C31H31F3N6O/c1-4-21-7-6-10-39(17-21)18-22-11-25-26(27(12-22)31(32,33)34)16-36-40(28(25)41)24-9-5-8-23(13-24)30(14-20(2)15-30)29-37-35-19-38(29)3/h1,5,8-9,11-13,16,19-21H,6-7,10,14-15,17-18H2,2-3H3	HTHKAMUZWUNCFC-UHFFFAOYSA-N	226997	US20260008770, Example 20	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 750							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226997&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963135	336294093							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149149	CC1=CCCN(Cc2cc(C(F)(F)F)c3cnn(-c4cccc(C5(c6nncn6C)CC(C)C5)c4)c(=O)c3c2)C1	InChI=1S/C30H31F3N6O/c1-19-6-5-9-38(16-19)17-21-10-24-25(26(11-21)30(31,32)33)15-35-39(27(24)40)23-8-4-7-22(12-23)29(13-20(2)14-29)28-36-34-18-37(28)3/h4,6-8,10-12,15,18,20H,5,9,13-14,16-17H2,1-3H3	VCGUAFHRQXXNPL-UHFFFAOYSA-N	226998	US20260008770, Example 21	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226998&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963136	336294094							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149150	CC1CC(c2cccc(-n3ncc4c(C(F)(F)F)cc(CN5CCCCC5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C29H31F3N6O/c1-19-14-28(15-19,27-35-33-18-36(27)2)21-7-6-8-22(13-21)38-26(39)23-11-20(17-37-9-4-3-5-10-37)12-25(29(30,31)32)24(23)16-34-38/h6-8,11-13,16,18-19H,3-5,9-10,14-15,17H2,1-2H3	JJPOYOZWRFDUCU-UHFFFAOYSA-N	226999	US20260008770, Example 22	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226999&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963137	336294095							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149151	CC1CC(c2cccc(-n3ccc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C31H34F3N5O/c1-20-6-5-10-38(17-20)18-22-12-26-25(27(13-22)31(32,33)34)9-11-39(28(26)40)24-8-4-7-23(14-24)30(15-21(2)16-30)29-36-35-19-37(29)3/h4,7-9,11-14,19-21H,5-6,10,15-18H2,1-3H3	CUTZDSZQVYBLNW-UHFFFAOYSA-N	227000	US20260008770, Example 23	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227000&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963138	336294096							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149152	CC1CC(c2cccc(NC(=O)c3cc(CN4CCC[C@H](C)C4)cc4c3OCCC4(F)F)c2)(c2nncn2C)C1	InChI=1S/C31H37F2N5O2/c1-20-6-5-10-38(17-20)18-22-12-25(27-26(13-22)31(32,33)9-11-40-27)28(39)35-24-8-4-7-23(14-24)30(15-21(2)16-30)29-36-34-19-37(29)3/h4,7-8,12-14,19-21H,5-6,9-11,15-18H2,1-3H3,(H,35,39)	PSTSSOWGKKCETJ-UHFFFAOYSA-N	227001	US20260008770, Example 24	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227001&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963139	336294097							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149153	CC1CC(c2cccc(NC(=O)c3cc(CN4CCC[C@H](C)C4)cc4c3OC(F)(F)O4)c2)(c2nncn2C)C1	InChI=1S/C29H33F2N5O3/c1-18-6-5-9-36(15-18)16-20-10-23(25-24(11-20)38-29(30,31)39-25)26(37)33-22-8-4-7-21(12-22)28(13-19(2)14-28)27-34-32-17-35(27)3/h4,7-8,10-12,17-19H,5-6,9,13-16H2,1-3H3,(H,33,37)	VLSCZHBAHVBDBM-UHFFFAOYSA-N	227002	US20260008770, Example 25	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227002&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963140	336294098							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149154	C[C@H]1CCCN(Cc2cc(C(=O)Nc3cccc([C@@H](c4nncn4C)C4COC4)c3)cc(C(F)(F)F)c2)C1	InChI=1S/C28H32F3N5O2/c1-18-5-4-8-36(13-18)14-19-9-21(11-23(10-19)28(29,30)31)27(37)33-24-7-3-6-20(12-24)25(22-15-38-16-22)26-34-32-17-35(26)2/h3,6-7,9-12,17-18,22,25H,4-5,8,13-16H2,1-2H3,(H,33,37)	MULALJFKIWSVSO-UHFFFAOYSA-N	227003	US20260008770, Example 26	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		>1000							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227003&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963141	336294099							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149155	C[C@H]1CCCN(Cc2cc(C(=O)Nc3cccc([C@H](c4nncn4C)C4COC4)c3)cc(C(F)(F)F)c2)C1	InChI=1S/C28H32F3N5O2/c1-18-5-4-8-36(13-18)14-19-9-21(11-23(10-19)28(29,30)31)27(37)33-24-7-3-6-20(12-24)25(22-15-38-16-22)26-34-32-17-35(26)2/h3,6-7,9-12,17-18,22,25H,4-5,8,13-16H2,1-2H3,(H,33,37)	MULALJFKIWSVSO-UHFFFAOYSA-N	227004	US20260008770, Example 27	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227004&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963142	336294100							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149156	C[C@H]1CCCN(Cc2cc(C(=O)Nc3cccc([C@]4(c5nncn5C)C[C@@H](C)C4)c3)c(F)c(C(F)(F)F)c2)C1	InChI=1S/C29H33F4N5O/c1-18-6-5-9-38(15-18)16-20-10-23(25(30)24(11-20)29(31,32)33)26(39)35-22-8-4-7-21(12-22)28(13-19(2)14-28)27-36-34-17-37(27)3/h4,7-8,10-12,17-19H,5-6,9,13-16H2,1-3H3,(H,35,39)	RBMVUVGBYXVXMY-UHFFFAOYSA-N	227005	US20260008770, Example 28	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227005&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963143	336294101							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149157	C[C@H]1CCCN(Cc2cc(C(=O)Nc3cccc([C@]4(c5nncn5C)C[C@H](C)C4)c3)c(F)c(C(F)(F)F)c2)C1	InChI=1S/C29H33F4N5O/c1-18-6-5-9-38(15-18)16-20-10-23(25(30)24(11-20)29(31,32)33)26(39)35-22-8-4-7-21(12-22)28(13-19(2)14-28)27-36-34-17-37(27)3/h4,7-8,10-12,17-19H,5-6,9,13-16H2,1-3H3,(H,35,39)	RBMVUVGBYXVXMY-UHFFFAOYSA-N	227006	US20260008770, Example 29	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227006&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963144	336294102							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149158	CC1CC(c2cccc(NC(=O)c3cc(CN4CCC[C@H](C)C4)cc(C(F)(F)F)c3)c2)(c2nncn2C)C1	InChI=1S/C29H34F3N5O/c1-19-6-5-9-37(16-19)17-21-10-22(12-24(11-21)29(30,31)32)26(38)34-25-8-4-7-23(13-25)28(14-20(2)15-28)27-35-33-18-36(27)3/h4,7-8,10-13,18-20H,5-6,9,14-17H2,1-3H3,(H,34,38)	QKHWQKJNZYFRBJ-UHFFFAOYSA-N	227007	US20260008770, Example 30	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227007&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963145	336294103							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149159	C[C@H]1CCCN(Cc2cc(C(=O)Nc3cccc(C(c4nncn4C)C4CCC4)c3)cc(C(F)(F)F)c2)C1	InChI=1S/C29H34F3N5O/c1-19-6-5-11-37(16-19)17-20-12-23(14-24(13-20)29(30,31)32)28(38)34-25-10-4-9-22(15-25)26(21-7-3-8-21)27-35-33-18-36(27)2/h4,9-10,12-15,18-19,21,26H,3,5-8,11,16-17H2,1-2H3,(H,34,38)	RFVXGZZUUBBCNF-UHFFFAOYSA-N	227008	US20260008770, Example 31	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227008&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963146	336294104							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149160	C#CC1CC(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C30H31F3N6/c1-4-21-14-29(15-21,28-35-34-19-37(28)3)23-8-5-9-24(13-23)39-18-25-26(30(31,32)33)11-22(12-27(25)36-39)17-38-10-6-7-20(2)16-38/h1,5,8-9,11-13,18-21H,6-7,10,14-17H2,2-3H3	GEHMCZWGMBWWIN-UHFFFAOYSA-N	227009	US20260008770, Example 32	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227009&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963147	336294105							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149161	COCC1CC(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C30H35F3N6O/c1-20-6-5-9-38(15-20)16-21-10-26(30(31,32)33)25-17-39(36-27(25)11-21)24-8-4-7-23(12-24)29(13-22(14-29)18-40-3)28-35-34-19-37(28)2/h4,7-8,10-12,17,19-20,22H,5-6,9,13-16,18H2,1-3H3	AIQYVTGZQCZWOF-UHFFFAOYSA-N	227010	US20260008770, Example 33	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227010&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963148	336294106							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149162	CC1CN(Cc2cc(C(F)(F)F)c3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)ccn4)c(=O)c3c2)CCC1(F)F	InChI=1S/C29H30F5N7O/c1-17-11-27(12-17,26-38-37-16-39(26)3)20-4-6-35-23(10-20)41-15-36-24-21(25(41)42)8-19(9-22(24)29(32,33)34)14-40-7-5-28(30,31)18(2)13-40/h4,6,8-10,15-18H,5,7,11-14H2,1-3H3	HMOFPBHNVIAIFZ-UHFFFAOYSA-N	227011	US20260008770, Example 34	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227011&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963149	336294107							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149163	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cc(C5(Cc6nncn6C)COC5)ccn4)c(=O)c3c2)C1	InChI=1S/C28H30F3N7O2/c1-18-4-3-7-37(12-18)13-19-8-21-25(22(9-19)28(29,30)31)33-16-38(26(21)39)23-10-20(5-6-32-23)27(14-40-15-27)11-24-35-34-17-36(24)2/h5-6,8-10,16-18H,3-4,7,11-15H2,1-2H3	HGRZFEGRHGLAPV-UHFFFAOYSA-N	227012	US20260008770, Example 35	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227012&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963150	336294108							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149164	Cn1cnnc1[C@]1(c2ccnc(-n3ncc4c(C(F)(F)F)cc(CN5CCC6(CC6)C5)cc4c3=O)c2)C[C@H](C)C1	InChI=1S/C29H30F3N7O/c1-18-12-28(13-18,26-36-34-17-37(26)2)20-3-7-33-24(11-20)39-25(40)21-9-19(15-38-8-6-27(16-38)4-5-27)10-23(29(30,31)32)22(21)14-35-39/h3,7,9-11,14,17-18H,4-6,8,12-13,15-16H2,1-2H3	UDSXUORSIZXKEG-UHFFFAOYSA-N	227013	US20260008770, Example 36	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227013&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963151	336294109							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149165	Cn1cnnc1[C@]1(c2ccnc(-n3ncc4c(C(F)(F)F)cc(CN5CCCC6(CC6)C5)cc4c3=O)c2)C[C@H](C)C1	InChI=1S/C30H32F3N7O/c1-19-13-29(14-19,27-37-35-18-38(27)2)21-4-8-34-25(12-21)40-26(41)22-10-20(11-24(30(31,32)33)23(22)15-36-40)16-39-9-3-5-28(17-39)6-7-28/h4,8,10-12,15,18-19H,3,5-7,9,13-14,16-17H2,1-2H3	QMHFVMKXASDSPX-UHFFFAOYSA-N	227014	US20260008770, Example 37	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227014&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963152	336294110							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149166	CC1CC(c2cc(OCF)nc(-n3ncc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H33F4N7O2/c1-18-5-4-6-40(14-18)15-20-7-22-23(24(8-20)30(32,33)34)13-36-41(27(22)42)25-9-21(10-26(37-25)43-16-31)29(11-19(2)12-29)28-38-35-17-39(28)3/h7-10,13,17-19H,4-6,11-12,14-16H2,1-3H3	WEBHTOAHPGRKNP-UHFFFAOYSA-N	227015	US20260008770, Example 38	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227015&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963153	336294111							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149167	Cn1cnnc1[C@]1(c2ccnc(-n3ncc4c(C(F)(F)F)cc(CN5CCOC6(CCC6)C5)cc4c3=O)c2)C[C@H](C)C1	InChI=1S/C30H32F3N7O2/c1-19-13-29(14-19,27-37-35-18-38(27)2)21-4-7-34-25(12-21)40-26(41)22-10-20(11-24(30(31,32)33)23(22)15-36-40)16-39-8-9-42-28(17-39)5-3-6-28/h4,7,10-12,15,18-19H,3,5-6,8-9,13-14,16-17H2,1-2H3	QNBDNUOQUULWKD-UHFFFAOYSA-N	227016	US20260008770, Example 39	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 750							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227016&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963154	336294112							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149168	Cn1cnnc1[C@]1(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCOC6(CCC6)C5)cc4n3)c2)C[C@H](C)C1	InChI=1S/C30H33F3N6O/c1-20-14-29(15-20,27-35-34-19-37(27)2)22-5-3-6-23(13-22)39-17-24-25(30(31,32)33)11-21(12-26(24)36-39)16-38-9-10-40-28(18-38)7-4-8-28/h3,5-6,11-13,17,19-20H,4,7-10,14-16,18H2,1-2H3	CODMIGGXJFOVFW-UHFFFAOYSA-N	227017	US20260008770, Example 40	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227017&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963155	336294113							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149169	CC1CC(c2cc(Cl)nc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C29H31ClF3N7O/c1-17-5-4-6-39(13-17)14-19-7-21-25(22(8-19)29(31,32)33)34-15-40(26(21)41)24-10-20(9-23(30)36-24)28(11-18(2)12-28)27-37-35-16-38(27)3/h7-10,15-18H,4-6,11-14H2,1-3H3	VCXFVORHQWPBAF-UHFFFAOYSA-N	227018	US20260008770, Example 41	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227018&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963156	336294114							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149170	C#CC[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc([C@]5(c6nncn6C)C[C@@H](C)C5)c4)nc3c2)C1	InChI=1S/C31H33F3N6/c1-4-7-22-8-6-11-39(17-22)18-23-12-27(31(32,33)34)26-19-40(37-28(26)13-23)25-10-5-9-24(14-25)30(15-21(2)16-30)29-36-35-20-38(29)3/h1,5,9-10,12-14,19-22H,6-8,11,15-18H2,2-3H3	LDTXFHLJYAGSLM-UHFFFAOYSA-N	227019	US20260008770, Example 42	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227019&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963157	336294115							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149171	CNC(=O)c1cc(-n2cc3c(C(F)(F)F)cc(CN4CCC[C@H](C)C4)cc3n2)cc(C2(c3nncn3C)CC(C)C2)c1	InChI=1S/C31H36F3N7O/c1-19-6-5-7-40(15-19)16-21-8-26(31(32,33)34)25-17-41(38-27(25)9-21)24-11-22(28(42)35-3)10-23(12-24)30(13-20(2)14-30)29-37-36-18-39(29)4/h8-12,17-20H,5-7,13-16H2,1-4H3,(H,35,42)	NUNUOPMDOOPKNJ-UHFFFAOYSA-N	227020	US20260008770, Example 43	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227020&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963158	336294116							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149172	CC1CC(c2cc(F)nc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C29H31F4N7O/c1-17-5-4-6-39(13-17)14-19-7-21-25(22(8-19)29(31,32)33)34-15-40(26(21)41)24-10-20(9-23(30)36-24)28(11-18(2)12-28)27-37-35-16-38(27)3/h7-10,15-18H,4-6,11-14H2,1-3H3	QAHIKGDDXGUGSS-UHFFFAOYSA-N	227021	US20260008770, Example 44	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227021&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963159	336294117							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149173	Cc1cc(C2(c3nncn3C)CC(C)C2)cc(-n2cnc3c(C(F)(F)F)cc(CN4CCC[C@H](C)C4)cc3c2=O)n1	InChI=1S/C30H34F3N7O/c1-18-6-5-7-39(14-18)15-21-9-23-26(24(10-21)30(31,32)33)34-16-40(27(23)41)25-11-22(8-20(3)36-25)29(12-19(2)13-29)28-37-35-17-38(28)4/h8-11,16-19H,5-7,12-15H2,1-4H3	GYYNHGDVZHFRMD-UHFFFAOYSA-N	227022	US20260008770, Example 45	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227022&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963155	336294118							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149174	CC1CC(c2ccnc(-n3cnc4c(C(F)(F)F)c(CN5CCC[C@H](C)C5)[nH]c4c3=O)c2)(c2nncn2C)C1	InChI=1S/C27H31F3N8O/c1-16-5-4-8-37(12-16)13-19-21(27(28,29)30)22-23(34-19)24(39)38(14-32-22)20-9-18(6-7-31-20)26(10-17(2)11-26)25-35-33-15-36(25)3/h6-7,9,14-17,34H,4-5,8,10-13H2,1-3H3	FQSPLVOJCGCOMH-UHFFFAOYSA-N	227023	US20260008770, Example 46	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227023&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963160	336294119							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149175	CC1CC(c2cc(C3CC3)nc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C32H36F3N7O/c1-19-5-4-8-41(15-19)16-21-9-24-28(25(10-21)32(33,34)35)36-17-42(29(24)43)27-12-23(11-26(38-27)22-6-7-22)31(13-20(2)14-31)30-39-37-18-40(30)3/h9-12,17-20,22H,4-8,13-16H2,1-3H3	OKMLPLUQLOGPEN-UHFFFAOYSA-N	227024	US20260008770, Example 47	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227024&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963161	336294120							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149176	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cc([C@]5(c6nncn6C(F)F)C[C@@H](C)C5)ccn4)c(=O)c3c2)C1	InChI=1S/C29H30F5N7O/c1-17-4-3-7-39(13-17)14-19-8-21-24(22(9-19)29(32,33)34)36-15-40(25(21)42)23-10-20(5-6-35-23)28(11-18(2)12-28)26-38-37-16-41(26)27(30)31/h5-6,8-10,15-18,27H,3-4,7,11-14H2,1-2H3	ZJBMVKPHFUGRKY-UHFFFAOYSA-N	227025	US20260008770, Example 48	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227025&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963162	336294121							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149177	C=Cc1cc(C2(c3nncn3C)CC(C)C2)cc(-n2cnc3c(C(F)(F)F)cc(CN4CCC[C@H](C)C4)cc3c2=O)n1	InChI=1S/C31H34F3N7O/c1-5-23-11-22(30(13-20(3)14-30)29-38-36-18-39(29)4)12-26(37-23)41-17-35-27-24(28(41)42)9-21(10-25(27)31(32,33)34)16-40-8-6-7-19(2)15-40/h5,9-12,17-20H,1,6-8,13-16H2,2-4H3	JHSAZIIMCAAIIO-UHFFFAOYSA-N	227026	US20260008770, Example 49	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227026&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963163	336294122							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149178	Cn1cnnc1C(F)C1(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C6CC6)C5)cc4n3)c2)COC1	InChI=1S/C30H32F4N6O/c1-38-18-35-36-28(38)27(31)29(16-41-17-29)22-5-2-6-23(12-22)40-15-24-25(30(32,33)34)10-19(11-26(24)37-40)13-39-9-3-4-21(14-39)20-7-8-20/h2,5-6,10-12,15,18,20-21,27H,3-4,7-9,13-14,16-17H2,1H3	JCZTWSDZUXRPRU-UHFFFAOYSA-N	227027	US20260008770, Example 50	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227027&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963164	336294123							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149179	C#Cc1cc(-n2cc3c(C(F)(F)F)cc(CN4CCC[C@H](C)C4)cc3n2)cc(C2(c3nncn3C)CC(C)C2)c1	InChI=1S/C31H33F3N6/c1-5-22-9-24(30(14-21(3)15-30)29-36-35-19-38(29)4)13-25(10-22)40-18-26-27(31(32,33)34)11-23(12-28(26)37-40)17-39-8-6-7-20(2)16-39/h1,9-13,18-21H,6-8,14-17H2,2-4H3	GWVKCMQHMMFGAS-UHFFFAOYSA-N	227028	US20260008770, Example 51	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227028&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963165	336294124							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149180	CC1CC(c2cc(C(N)=O)cc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C30H34F3N7O/c1-18-5-4-6-39(14-18)15-20-7-25(30(31,32)33)24-16-40(37-26(24)8-20)23-10-21(27(34)41)9-22(11-23)29(12-19(2)13-29)28-36-35-17-38(28)3/h7-11,16-19H,4-6,12-15H2,1-3H3,(H2,34,41)	YEVGBESRLZWPRF-UHFFFAOYSA-N	227029	US20260008770, Example 52	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227029&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963166	336294125							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149181	N#Cc1cc(-n2cc3c(C(F)(F)F)cc(CN4CCC[C@H](C)C4)cc3n2)cc(C2(c3nncn3C)CC(C)C2)c1	InChI=1S/C30H32F3N7/c1-19-5-4-6-39(15-19)16-22-9-26(30(31,32)33)25-17-40(37-27(25)10-22)24-8-21(14-34)7-23(11-24)29(12-20(2)13-29)28-36-35-18-38(28)3/h7-11,17-20H,4-6,12-13,15-16H2,1-3H3	HEZJRPJUQKONHQ-UHFFFAOYSA-N	227030	US20260008770, Example 53	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227030&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963167	336294126							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149182	CC1CC(c2cncc(-n3ncc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C29H32F3N7O/c1-18-5-4-6-38(15-18)16-20-7-23-24(25(8-20)29(30,31)32)14-35-39(26(23)40)22-9-21(12-33-13-22)28(10-19(2)11-28)27-36-34-17-37(27)3/h7-9,12-14,17-19H,4-6,10-11,15-16H2,1-3H3	HGEJLXUBYIUHBD-UHFFFAOYSA-N	227031	US20260008770, Example 54	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227031&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963168	336294127							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149183	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cnn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)ccn4)c(=O)c3c2)C1	InChI=1S/C29H32F3N7O/c1-18-5-4-8-38(15-18)16-20-9-22-23(24(10-20)29(30,31)32)14-35-39(26(22)40)25-11-21(6-7-33-25)28(12-19(2)13-28)27-36-34-17-37(27)3/h6-7,9-11,14,17-19H,4-5,8,12-13,15-16H2,1-3H3	AIBXMZSTRNLRAF-UHFFFAOYSA-N	227032	US20260008770, Example 55	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 750							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227032&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963169	336294128							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149184	C#C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc([C@]5(c6nncn6C)C[C@@H](C)C5)c4)nc3c2)C1	InChI=1S/C30H31F3N6/c1-4-21-7-6-10-38(16-21)17-22-11-26(30(31,32)33)25-18-39(36-27(25)12-22)24-9-5-8-23(13-24)29(14-20(2)15-29)28-35-34-19-37(28)3/h1,5,8-9,11-13,18-21H,6-7,10,14-17H2,2-3H3	SKZPMWTVUGZBAB-UHFFFAOYSA-N	227033	US20260008770, Example 56	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227033&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963170	336294129							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149185	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc(C5(C(F)c6nncn6C)COC5)c4)nc3c2)C1	InChI=1S/C28H30F4N6O/c1-18-5-4-8-37(12-18)13-19-9-23(28(30,31)32)22-14-38(35-24(22)10-19)21-7-3-6-20(11-21)27(15-39-16-27)25(29)26-34-33-17-36(26)2/h3,6-7,9-11,14,17-18,25H,4-5,8,12-13,15-16H2,1-2H3	ZETDKUADSBGERO-UHFFFAOYSA-N	227034	US20260008770, Example 57	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227034&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963165	336294130							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149186	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)ccn4)nc3c2)C1	InChI=1S/C28H32F3N7/c1-18-5-4-8-37(14-18)15-20-9-23(28(29,30)31)22-16-38(35-24(22)10-20)25-11-21(6-7-32-25)27(12-19(2)13-27)26-34-33-17-36(26)3/h6-7,9-11,16-19H,4-5,8,12-15H2,1-3H3	SPTPUTOGODRTGP-UHFFFAOYSA-N	227035	US20260008770, Example 58	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227035&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963171	336294131							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149187	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc(C5(c6nncn6C)CC(OC(F)F)C5)c4)nc3c2)C1	InChI=1S/C29H31F5N6O/c1-18-5-4-8-39(14-18)15-19-9-24(29(32,33)34)23-16-40(37-25(23)10-19)21-7-3-6-20(11-21)28(26-36-35-17-38(26)2)12-22(13-28)41-27(30)31/h3,6-7,9-11,16-18,22,27H,4-5,8,12-15H2,1-2H3	COGXFHZTCRTQTG-UHFFFAOYSA-N	227036	US20260008770, Example 59	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227036&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963172	336294132							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149188	CC1CC(c2cc(CO)cc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C30H35F3N6O/c1-19-5-4-6-38(14-19)15-21-9-26(30(31,32)33)25-16-39(36-27(25)10-21)24-8-22(17-40)7-23(11-24)29(12-20(2)13-29)28-35-34-18-37(28)3/h7-11,16,18-20,40H,4-6,12-15,17H2,1-3H3	PREXQPRZUGHLAN-UHFFFAOYSA-N	227037	US20260008770, Example 60	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227037&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963173	336294133							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149189	C#C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)ccn4)c(=O)c3c2)C1	InChI=1S/C30H30F3N7O/c1-4-20-6-5-9-39(15-20)16-21-10-23-26(24(11-21)30(31,32)33)35-17-40(27(23)41)25-12-22(7-8-34-25)29(13-19(2)14-29)28-37-36-18-38(28)3/h1,7-8,10-12,17-20H,5-6,9,13-16H2,2-3H3	ZNMHOEASLINSGY-UHFFFAOYSA-N	227038	US20260008770, Example 61	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227038&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963174	336294134							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149190	C[C@H]1CCCN(Cc2cc3c(=O)n(-c4cccc([C@]5(c6nncn6C)C[C@@H](C)C5)c4)cnc3c(C(F)(F)F)n2)C1	InChI=1S/C29H32F3N7O/c1-18-6-5-9-38(14-18)15-21-11-23-24(25(35-21)29(30,31)32)33-16-39(26(23)40)22-8-4-7-20(10-22)28(12-19(2)13-28)27-36-34-17-37(27)3/h4,7-8,10-11,16-19H,5-6,9,12-15H2,1-3H3	AJIROWRUZSGFIZ-UHFFFAOYSA-N	227039	US20260008770, Example 62	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227039&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963175	336294135							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149191	CC1CC(c2cccc(-n3cnc4c(C(F)(F)F)c(CN5CCC[C@H](C)C5)[nH]c4c3=O)c2)(c2nncn2C)C1	InChI=1S/C28H32F3N7O/c1-17-6-5-9-37(13-17)14-21-22(28(29,30)31)23-24(34-21)25(39)38(15-32-23)20-8-4-7-19(10-20)27(11-18(2)12-27)26-35-33-16-36(26)3/h4,7-8,10,15-18,34H,5-6,9,11-14H2,1-3H3	NAIQSKXOPAAIQS-UHFFFAOYSA-N	227040	US20260008770, Example 63	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227040&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963176	336294136							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149192	Cn1cnnc1CC1(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C6CC6)C5)cc4n3)c2)COC1	InChI=1S/C30H33F3N6O/c1-37-19-34-35-28(37)13-29(17-40-18-29)23-5-2-6-24(12-23)39-16-25-26(30(31,32)33)10-20(11-27(25)36-39)14-38-9-3-4-22(15-38)21-7-8-21/h2,5-6,10-12,16,19,21-22H,3-4,7-9,13-15,17-18H2,1H3	SMRUPQKOJQQUKM-UHFFFAOYSA-N	227041	US20260008770, Example 64	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227041&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963177	336294137							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149193	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cnn(-c4cc([C@]5(c6nncn6C)C[C@H](C)C5)ccn4)c(=O)c3c2)C1	InChI=1S/C29H32F3N7O/c1-18-5-4-8-38(15-18)16-20-9-22-23(24(10-20)29(30,31)32)14-35-39(26(22)40)25-11-21(6-7-33-25)28(12-19(2)13-28)27-36-34-17-37(27)3/h6-7,9-11,14,17-19H,4-5,8,12-13,15-16H2,1-3H3	AIBXMZSTRNLRAF-UHFFFAOYSA-N	227042	US20260008770, Example 65	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 750							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227042&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963178	336294138							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149194	C#CCC1CC(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C31H33F3N6/c1-4-7-22-15-30(16-22,29-36-35-20-38(29)3)24-9-5-10-25(14-24)40-19-26-27(31(32,33)34)12-23(13-28(26)37-40)18-39-11-6-8-21(2)17-39/h1,5,9-10,12-14,19-22H,6-8,11,15-18H2,2-3H3	ZHWGBANHEWTWLE-UHFFFAOYSA-N	227043	US20260008770, Example 66	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227043&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963179	336294139							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149195	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cccc(C5(c6nncn6C)CC(=O)C5)c4)c(=O)c3c2)C1	InChI=1S/C29H29F3N6O2/c1-18-5-4-8-37(14-18)15-19-9-23-25(24(10-19)29(30,31)32)33-16-38(26(23)40)21-7-3-6-20(11-21)28(12-22(39)13-28)27-35-34-17-36(27)2/h3,6-7,9-11,16-18H,4-5,8,12-15H2,1-2H3	XPOSRWIQCZACHR-UHFFFAOYSA-N	227044	US20260008770, Example 67	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227044&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963180	336294140							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149196	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc(C5(c6nncn6C)CC(=O)C5)c4)nc3c2)C1	InChI=1S/C28H29F3N6O/c1-18-5-4-8-36(14-18)15-19-9-24(28(29,30)31)23-16-37(34-25(23)10-19)21-7-3-6-20(11-21)27(12-22(38)13-27)26-33-32-17-35(26)2/h3,6-7,9-11,16-18H,4-5,8,12-15H2,1-2H3	KKRIFFMTYFFRAH-UHFFFAOYSA-N	227045	US20260008770, Example 68	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227045&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963181	336294141							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149197	C#C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc(C5(Cc6nncn6C)COC5)c4)nc3c2)C1	InChI=1S/C29H29F3N6O/c1-3-20-6-5-9-37(14-20)15-21-10-25(29(30,31)32)24-16-38(35-26(24)11-21)23-8-4-7-22(12-23)28(17-39-18-28)13-27-34-33-19-36(27)2/h1,4,7-8,10-12,16,19-20H,5-6,9,13-15,17-18H2,2H3	QTDPOMHYXNEBGV-UHFFFAOYSA-N	227046	US20260008770, Example 69	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227046&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963182	336294142							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149198	C=C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc(C5(c6nncn6C)CC(C)C5)c4)nc3c2)C1	InChI=1S/C30H33F3N6/c1-4-21-7-6-10-38(16-21)17-22-11-26(30(31,32)33)25-18-39(36-27(25)12-22)24-9-5-8-23(13-24)29(14-20(2)15-29)28-35-34-19-37(28)3/h4-5,8-9,11-13,18-21H,1,6-7,10,14-17H2,2-3H3	GMODEHAEYRFTQB-UHFFFAOYSA-N	227047	US20260008770, Example 70	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227047&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963183	336294143							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149199	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cc([C@]5(c6nncn6C)C[C@H](C)C5)ccn4)nc3c2)C1	InChI=1S/C28H32F3N7/c1-18-5-4-8-37(14-18)15-20-9-23(28(29,30)31)22-16-38(35-24(22)10-20)25-11-21(6-7-32-25)27(12-19(2)13-27)26-34-33-17-36(26)3/h6-7,9-11,16-19H,4-5,8,12-15H2,1-3H3	SPTPUTOGODRTGP-UHFFFAOYSA-N	227048	US20260008770, Example 71	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227048&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963184	336294144							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149200	CC1CC(c2ccc(F)c(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C29H32F4N6/c1-18-5-4-8-38(14-18)15-20-9-23(29(31,32)33)22-16-39(36-25(22)10-20)26-11-21(6-7-24(26)30)28(12-19(2)13-28)27-35-34-17-37(27)3/h6-7,9-11,16-19H,4-5,8,12-15H2,1-3H3	LPICRHVHIGLWDI-UHFFFAOYSA-N	227049	US20260008770, Example 72	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227049&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963177	336294145							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149201	CC1CC(c2cccc(-n3[nH]c4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C29H33F3N6O/c1-18-6-5-9-37(15-18)16-20-10-23-25(24(11-20)29(30,31)32)35-38(26(23)39)22-8-4-7-21(12-22)28(13-19(2)14-28)27-34-33-17-36(27)3/h4,7-8,10-12,17-19,35H,5-6,9,13-16H2,1-3H3	GKFMBGWRRJHAAC-UHFFFAOYSA-N	227050	US20260008770, Example 73	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		>1000							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227050&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963185	336294146							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149202	Cn1cnnc1[C@]1(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](OC(F)F)C5)cc4n3)c2)C[C@H](C)C1	InChI=1S/C29H31F5N6O/c1-18-12-28(13-18,26-36-35-17-38(26)2)20-5-3-6-21(11-20)40-16-23-24(29(32,33)34)9-19(10-25(23)37-40)14-39-8-4-7-22(15-39)41-27(30)31/h3,5-6,9-11,16-18,22,27H,4,7-8,12-15H2,1-2H3	FURHXKCLTQOQIU-UHFFFAOYSA-N	227051	US20260008770, Example 74	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227051&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963186	336294147							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149203	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cc(C5(Cc6nncn6C)COC5)cc5c4OCC5)nc3c2)C1	InChI=1S/C30H33F3N6O2/c1-19-4-3-6-38(13-19)14-20-8-24(30(31,32)33)23-15-39(36-25(23)9-20)26-11-22(10-21-5-7-41-28(21)26)29(16-40-17-29)12-27-35-34-18-37(27)2/h8-11,15,18-19H,3-7,12-14,16-17H2,1-2H3	BRJGNDFZJMWABX-UHFFFAOYSA-N	227052	US20260008770, Example 75	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227052&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963187	336294148							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149204	COCC1CC(c2cccc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C31H35F3N6O2/c1-20-6-5-9-39(15-20)16-21-10-25-27(26(11-21)31(32,33)34)35-18-40(28(25)41)24-8-4-7-23(12-24)30(13-22(14-30)17-42-3)29-37-36-19-38(29)2/h4,7-8,10-12,18-20,22H,5-6,9,13-17H2,1-3H3	CZJZTBLOHKZSQO-UHFFFAOYSA-N	227053	US20260008770, Example 76	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227053&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963188	336294149							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149205	CC1CC(c2cncc(-n3ncc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C29H32F3N7O/c1-18-5-4-6-38(15-18)16-20-7-23-24(25(8-20)29(30,31)32)14-35-39(26(23)40)22-9-21(12-33-13-22)28(10-19(2)11-28)27-36-34-17-37(27)3/h7-9,12-14,17-19H,4-6,10-11,15-16H2,1-3H3	HGEJLXUBYIUHBD-UHFFFAOYSA-N	227054	US20260008770, Example 77	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227054&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963189	336294150							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149206	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)ccn4)c(=O)c3c2)C1	InChI=1S/C29H32F3N7O/c1-18-5-4-8-38(14-18)15-20-9-22-25(23(10-20)29(30,31)32)34-16-39(26(22)40)24-11-21(6-7-33-24)28(12-19(2)13-28)27-36-35-17-37(27)3/h6-7,9-11,16-19H,4-5,8,12-15H2,1-3H3	XADIXHNVHSRGOY-UHFFFAOYSA-N	227055	US20260008770, Example 78	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227055&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963190	336294151							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149207	CC1=CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc(C5(c6nncn6C)CC(C)C5)c4)nc3c2)C1	InChI=1S/C29H31F3N6/c1-19-6-5-9-37(15-19)16-21-10-25(29(30,31)32)24-17-38(35-26(24)11-21)23-8-4-7-22(12-23)28(13-20(2)14-28)27-34-33-18-36(27)3/h4,6-8,10-12,17-18,20H,5,9,13-16H2,1-3H3	CBCMNHSVHWRTHH-UHFFFAOYSA-N	227056	US20260008770, Example 79	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227056&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963191	336294152							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149208	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cccc(C5(Cc6nncn6C)COC5)c4)c(=O)c3c2)C1	InChI=1S/C29H31F3N6O2/c1-19-5-4-8-37(13-19)14-20-9-23-26(24(10-20)29(30,31)32)33-17-38(27(23)39)22-7-3-6-21(11-22)28(15-40-16-28)12-25-35-34-18-36(25)2/h3,6-7,9-11,17-19H,4-5,8,12-16H2,1-2H3	OTLNOVVXDCVSOI-UHFFFAOYSA-N	227057	US20260008770, Example 80	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 750							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227057&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963192	336294153							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149209	CC1CC(c2cccc(-n3[nH]c(=O)c4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H33F3N6O2/c1-18-6-5-9-38(15-18)16-20-10-23-25(24(11-20)30(31,32)33)26(40)36-39(27(23)41)22-8-4-7-21(12-22)29(13-19(2)14-29)28-35-34-17-37(28)3/h4,7-8,10-12,17-19H,5-6,9,13-16H2,1-3H3,(H,36,40)	BAGCBAGTGOKOHK-UHFFFAOYSA-N	227058	US20260008770, Example 81	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227058&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963193	336294154							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149210	CC1CC(c2cccc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C(F)F)C1	InChI=1S/C30H31F5N6O/c1-18-5-4-8-39(14-18)15-20-9-23-25(24(10-20)30(33,34)35)36-16-40(26(23)42)22-7-3-6-21(11-22)29(12-19(2)13-29)27-38-37-17-41(27)28(31)32/h3,6-7,9-11,16-19,28H,4-5,8,12-15H2,1-2H3	NKACWQGGDVOCCX-UHFFFAOYSA-N	227059	US20260008770, Example 82	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227059&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963194	336294155							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149211	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cnn(-c4cccc(C5(c6nncn6C)CC(F)(F)C5)c4)c(=O)c3c2)C1	InChI=1S/C29H29F5N6O/c1-18-5-4-8-39(13-18)14-19-9-22-23(24(10-19)29(32,33)34)12-36-40(25(22)41)21-7-3-6-20(11-21)27(15-28(30,31)16-27)26-37-35-17-38(26)2/h3,6-7,9-12,17-18H,4-5,8,13-16H2,1-2H3	VTLJCYFKAVBVGU-UHFFFAOYSA-N	227060	US20260008770, Example 83	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227060&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963195	336294156							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149212	CC1CC(c2cccc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H33F3N6O/c1-19-6-5-9-38(15-19)16-21-10-24-26(25(11-21)30(31,32)33)34-17-39(27(24)40)23-8-4-7-22(12-23)29(13-20(2)14-29)28-36-35-18-37(28)3/h4,7-8,10-12,17-20H,5-6,9,13-16H2,1-3H3	OPLYLGJCVDRCFK-UHFFFAOYSA-N	227061	US20260008770, Example 84	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227061&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963196	336294157							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149213	CC1CC(c2cccc(-n3[nH]c(=O)c4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H33F3N6O2/c1-18-6-5-9-38(15-18)16-20-10-23-25(24(11-20)30(31,32)33)26(40)36-39(27(23)41)22-8-4-7-21(12-22)29(13-19(2)14-29)28-35-34-17-37(28)3/h4,7-8,10-12,17-19H,5-6,9,13-16H2,1-3H3,(H,36,40)	BAGCBAGTGOKOHK-UHFFFAOYSA-N	227062	US20260008770, Example 85	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227062&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963197	336294158							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149214	CC1CC(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5C[C@@H](C)C[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C30H35F3N6/c1-19-8-20(2)15-38(14-19)16-22-9-26(30(31,32)33)25-17-39(36-27(25)10-22)24-7-5-6-23(11-24)29(12-21(3)13-29)28-35-34-18-37(28)4/h5-7,9-11,17-21H,8,12-16H2,1-4H3	MIZYXIYWCHBTIH-UHFFFAOYSA-N	227063	US20260008770, Example 86	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227063&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963198	336294159							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149215	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc(C5(c6nncn6C)CC(F)(F)C5)c4)nc3c2)C1	InChI=1S/C28H29F5N6/c1-18-5-4-8-38(12-18)13-19-9-23(28(31,32)33)22-14-39(36-24(22)10-19)21-7-3-6-20(11-21)26(15-27(29,30)16-26)25-35-34-17-37(25)2/h3,6-7,9-11,14,17-18H,4-5,8,12-13,15-16H2,1-2H3	YQHIQVQYPKXSQI-UHFFFAOYSA-N	227064	US20260008770, Example 87	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227064&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963199	336294160							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149216	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc(C5(Cc6nncn6C)COC5)c4)nc3c2)C1	InChI=1S/C28H31F3N6O/c1-19-5-4-8-36(13-19)14-20-9-24(28(29,30)31)23-15-37(34-25(23)10-20)22-7-3-6-21(11-22)27(16-38-17-27)12-26-33-32-18-35(26)2/h3,6-7,9-11,15,18-19H,4-5,8,12-14,16-17H2,1-2H3	YVJJQEVHZIVUKL-UHFFFAOYSA-N	227065	US20260008770, Example 88	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227065&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963200	336294161							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149217	CC1CC(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@@](C)(O)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C29H33F3N6O/c1-19-13-28(14-19,26-34-33-18-36(26)3)21-6-4-7-22(12-21)38-16-23-24(29(30,31)32)10-20(11-25(23)35-38)15-37-9-5-8-27(2,39)17-37/h4,6-7,10-12,16,18-19,39H,5,8-9,13-15,17H2,1-3H3	NKIZHTOKYRMNBS-UHFFFAOYSA-N	227066	US20260008770, Example 89	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227066&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963201	336294162							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149218	N#CCC1CC(c2cccc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C30H32F3N7/c1-20-5-4-10-39(16-20)17-22-11-26(30(31,32)33)25-18-40(37-27(25)12-22)24-7-3-6-23(13-24)29(14-21(15-29)8-9-34)28-36-35-19-38(28)2/h3,6-7,11-13,18-21H,4-5,8,10,14-17H2,1-2H3	OJWFUEMNLRAWKC-UHFFFAOYSA-N	227067	US20260008770, Example 90	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227067&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963202	336294163							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149219	CC1CC(c2cncc(-n3cc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4n3)c2)(c2nncn2C)C1	InChI=1S/C28H32F3N7/c1-18-5-4-6-37(14-18)15-20-7-24(28(29,30)31)23-16-38(35-25(23)8-20)22-9-21(12-32-13-22)27(10-19(2)11-27)26-34-33-17-36(26)3/h7-9,12-13,16-19H,4-6,10-11,14-15H2,1-3H3	SBLPTNPDKJVLOA-UHFFFAOYSA-N	227068	US20260008770, Example 91	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227068&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963203	336294164							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149220	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3cn(-c4cccc([C@]5(c6nncn6C)C[C@@H](OC(F)(F)F)C5)c4)nc3c2)C1	InChI=1S/C29H30F6N6O/c1-18-5-4-8-40(14-18)15-19-9-24(28(30,31)32)23-16-41(38-25(23)10-19)21-7-3-6-20(11-21)27(26-37-36-17-39(26)2)12-22(13-27)42-29(33,34)35/h3,6-7,9-11,16-18,22H,4-5,8,12-15H2,1-2H3	AFTWUEPYKOAGOB-UHFFFAOYSA-N	227069	US20260008770, Example 92	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227069&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963204	336294165							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149221	CCc1cc([C@]2(c3nncn3C)C[C@@H](C)C2)cc(-n2cnc3ccc(CN4CCC[C@H](C)C4)cc3c2=O)n1	InChI=1S/C30H37N7O/c1-5-24-12-23(30(14-21(3)15-30)29-34-32-19-35(29)4)13-27(33-24)37-18-31-26-9-8-22(11-25(26)28(37)38)17-36-10-6-7-20(2)16-36/h8-9,11-13,18-21H,5-7,10,14-17H2,1-4H3	VCHNFJCNSQPPBX-UHFFFAOYSA-N	227070	US20260008770, Example 93	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227070&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963205	336294166							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149222	C=Cc1cc([C@]2(c3nncn3C)C[C@@H](C)C2)cc(-n2cnc3ccc(CN4CCC[C@H](C)C4)cc3c2=O)n1	InChI=1S/C30H35N7O/c1-5-24-12-23(30(14-21(3)15-30)29-34-32-19-35(29)4)13-27(33-24)37-18-31-26-9-8-22(11-25(26)28(37)38)17-36-10-6-7-20(2)16-36/h5,8-9,11-13,18-21H,1,6-7,10,14-17H2,2-4H3	BVGANKHDXKPMLG-UHFFFAOYSA-N	227071	US20260008770, Example 94	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227071&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963206	336294167							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149223	CC(c1ccc2ncn(-c3cc([C@]4(c5nncn5C)C[C@@H](C)C4)cc(OCF)n3)c(=O)c2c1)N1CCC[C@H](C)C1	InChI=1S/C30H36FN7O2/c1-19-6-5-9-37(15-19)21(3)22-7-8-25-24(10-22)28(39)38(17-32-25)26-11-23(12-27(34-26)40-16-31)30(13-20(2)14-30)29-35-33-18-36(29)4/h7-8,10-12,17-21H,5-6,9,13-16H2,1-4H3	VGVYEPAJYVOBHJ-UHFFFAOYSA-N	227072	US20260008770, Example 95	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227072&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963207	336294168							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149224	C[C@H]1CCCN(Cc2ccc3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)cc(C5CC5)n4)c(=O)c3c2)C1	InChI=1S/C31H37N7O/c1-20-5-4-10-37(16-20)17-22-6-9-26-25(11-22)29(39)38(18-32-26)28-13-24(12-27(34-28)23-7-8-23)31(14-21(2)15-31)30-35-33-19-36(30)3/h6,9,11-13,18-21,23H,4-5,7-8,10,14-17H2,1-3H3	WPUCWKSWWYSKHJ-UHFFFAOYSA-N	227073	US20260008770, Example 96	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227073&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963208	336294169							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149225	C#Cc1cc([C@]2(c3nncn3C)C[C@@H](C)C2)cc(-n2cnc3ccc(CN4CCC[C@H](C)C4)cc3c2=O)n1	InChI=1S/C30H33N7O/c1-5-24-12-23(30(14-21(3)15-30)29-34-32-19-35(29)4)13-27(33-24)37-18-31-26-9-8-22(11-25(26)28(37)38)17-36-10-6-7-20(2)16-36/h1,8-9,11-13,18-21H,6-7,10,14-17H2,2-4H3	IADBDSBTNFKAIP-UHFFFAOYSA-N	227074	US20260008770, Example 97	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227074&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963209	336294170							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149226	Cn1cnnc1[C@]1(c2cc(OCF)nc(-n3cnc4ccc(CN5CCC[C@H](F)C5)cc4c3=O)c2)C[C@H](C)C1	InChI=1S/C28H31F2N7O2/c1-18-11-28(12-18,27-34-32-17-35(27)2)20-9-24(33-25(10-20)39-15-29)37-16-31-23-6-5-19(8-22(23)26(37)38)13-36-7-3-4-21(30)14-36/h5-6,8-10,16-18,21H,3-4,7,11-15H2,1-2H3	RDQIDAPLOSUJOS-UHFFFAOYSA-N	227075	US20260008770, Example 98	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227075&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963210	336294171							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149227	Cn1cnnc1[C@]1(c2cc(OCF)nc(-n3cnc4cnc(CN5CCC[C@H](F)C5)cc4c3=O)c2)C[C@H](C)C1	InChI=1S/C27H30F2N8O2/c1-17-9-27(10-17,26-34-32-16-35(26)2)18-6-23(33-24(7-18)39-14-28)37-15-31-22-11-30-20(8-21(22)25(37)38)13-36-5-3-4-19(29)12-36/h6-8,11,15-17,19H,3-5,9-10,12-14H2,1-2H3	NRAVBNBBXIOLFQ-UHFFFAOYSA-N	227076	US20260008770, Example 99	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227076&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963211	336294172							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149228	C[C@H]1CCCN(Cc2cc3c(=O)n(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)cc(OCF)n4)cnc3cc2F)C1	InChI=1S/C29H33F2N7O2/c1-18-5-4-6-37(13-18)14-20-7-22-24(10-23(20)31)32-16-38(27(22)39)25-8-21(9-26(34-25)40-15-30)29(11-19(2)12-29)28-35-33-17-36(28)3/h7-10,16-19H,4-6,11-15H2,1-3H3	MFZFONNELXWQDP-UHFFFAOYSA-N	227077	US20260008770, Example 100	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227077&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963212	336294173							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149229	C#CC1CC(c2ccnc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H30F3N7O/c1-4-20-13-29(14-20,28-37-36-18-38(28)3)22-7-8-34-25(12-22)40-17-35-26-23(27(40)41)10-21(11-24(26)30(31,32)33)16-39-9-5-6-19(2)15-39/h1,7-8,10-12,17-20H,5-6,9,13-16H2,2-3H3	MISVUXRIQGLQOX-UHFFFAOYSA-N	227078	US20260008770, Example 101	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227078&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963213	336294174							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149230	Cn1cnnc1[C@]1(c2cc(OCF)nc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](F)C5)cc4c3=O)c2)C[C@H](C)C1	InChI=1S/C29H30F5N7O2/c1-17-10-28(11-17,27-38-36-16-39(27)2)19-8-23(37-24(9-19)43-14-30)41-15-35-25-21(26(41)42)6-18(7-22(25)29(32,33)34)12-40-5-3-4-20(31)13-40/h6-9,15-17,20H,3-5,10-14H2,1-2H3	BDPCOIQQRWOJBG-UHFFFAOYSA-N	227079	US20260008770, Example 102	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227079&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963214	336294175							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149231	CC1CC(c2cc(OC(F)F)nc(-n3cnc4c(C(F)(F)F)cc(C(C)N5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C31H34F5N7O2/c1-17-6-5-7-42(14-17)19(3)20-8-22-26(23(9-20)31(34,35)36)37-15-43(27(22)44)24-10-21(11-25(39-24)45-29(32)33)30(12-18(2)13-30)28-40-38-16-41(28)4/h8-11,15-19,29H,5-7,12-14H2,1-4H3	WPCZXQWRMQVFRR-UHFFFAOYSA-N	227080	US20260008770, Example 103	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227080&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963215	336294176							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149232	[2H]C([2H])(c1cc(C(F)(F)F)c2ncn(-c3cccc([C@]4(c5nncn5C)C[C@@H](C)C4)c3)c(=O)c2c1)N1CCC[C@H](C)C1	InChI=1S/C30H33F3N6O/c1-19-6-5-9-38(15-19)16-21-10-24-26(25(11-21)30(31,32)33)34-17-39(27(24)40)23-8-4-7-22(12-23)29(13-20(2)14-29)28-36-35-18-37(28)3/h4,7-8,10-12,17-20H,5-6,9,13-16H2,1-3H3/i16D2	OPLYLGJCVDRCFK-BPPAMHLBSA-N	227081	US20260008770, Example 104	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227081&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963216	336294177							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149233	Cn1cnnc1[C@]1(c2ccnc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](CF)C5)cc4c3=O)c2)C[C@H](C)C1	InChI=1S/C29H31F4N7O/c1-18-11-28(12-18,27-37-36-17-38(27)2)21-5-6-34-24(10-21)40-16-35-25-22(26(40)41)8-20(9-23(25)29(31,32)33)15-39-7-3-4-19(13-30)14-39/h5-6,8-10,16-19H,3-4,7,11-15H2,1-2H3	HYUBHTRYCIWTFY-UHFFFAOYSA-N	227082	US20260008770, Example 105	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227082	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227082&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963217	336294178							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149234	C[C@@H]1CN(Cc2cc(C(F)(F)F)c3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)cc(OCF)n4)c(=O)c3c2)CCC1F	InChI=1S/C30H32F5N7O2/c1-17-10-29(11-17,28-39-37-16-40(28)3)20-8-24(38-25(9-20)44-14-31)42-15-36-26-21(27(42)43)6-19(7-22(26)30(33,34)35)13-41-5-4-23(32)18(2)12-41/h6-9,15-18,23H,4-5,10-14H2,1-3H3	NZVFWPJEHPPSAD-UHFFFAOYSA-N	227083	US20260008770, Example 106	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227083&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963218	336294179							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149235	C=C(F)c1cc([C@]2(c3nncn3C)C[C@@H](C)C2)cc(-n2cnc3c(C(F)(F)F)cc(CN4CCC[C@H](C)C4)cc3c2=O)n1	InChI=1S/C31H33F4N7O/c1-18-6-5-7-41(14-18)15-21-8-23-27(24(9-21)31(33,34)35)36-16-42(28(23)43)26-11-22(10-25(38-26)20(3)32)30(12-19(2)13-30)29-39-37-17-40(29)4/h8-11,16-19H,3,5-7,12-15H2,1-2,4H3	ODISKKCTZKFERN-UHFFFAOYSA-N	227084	US20260008770, Example 107	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227084&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			121297533	336294180							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149236	Cn1cnnc1[C@]1(c2cc(OCF)nc(-n3cnc4c(C(F)(F)F)cc(CN5CCCC(C)(F)C5)cc4c3=O)c2)C[C@H](C)C1	InChI=1S/C30H32F5N7O2/c1-18-11-29(12-18,27-39-37-17-40(27)3)20-9-23(38-24(10-20)44-15-31)42-16-36-25-21(26(42)43)7-19(8-22(25)30(33,34)35)13-41-6-4-5-28(2,32)14-41/h7-10,16-18H,4-6,11-15H2,1-3H3	OUHVFDXKEQLMAH-UHFFFAOYSA-N	227085	US20260008770, Example 108	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227085&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963219	336294181							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149237	CC1CN(Cc2cc(C(F)(F)F)c3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)cc(OCF)n4)c(=O)c3c2)CCC1(F)F	InChI=1S/C30H31F6N7O2/c1-17-10-28(11-17,27-40-38-16-41(27)3)20-8-23(39-24(9-20)45-14-31)43-15-37-25-21(26(43)44)6-19(7-22(25)30(34,35)36)13-42-5-4-29(32,33)18(2)12-42/h6-9,15-18H,4-5,10-14H2,1-3H3	VPFPKAQFLJFPQZ-UHFFFAOYSA-N	227086	US20260008770, Example 109	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227086&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963220	336294182							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149238	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cc([C@]5(c6nncn6C6CCC6)C[C@@H](C)C5)ccn4)c(=O)c3c2)C1	InChI=1S/C32H36F3N7O/c1-20-5-4-10-40(16-20)17-22-11-25-28(26(12-22)32(33,34)35)37-18-42(29(25)43)27-13-23(8-9-36-27)31(14-21(2)15-31)30-39-38-19-41(30)24-6-3-7-24/h8-9,11-13,18-21,24H,3-7,10,14-17H2,1-2H3	IPEOEWWNUWLCTK-UHFFFAOYSA-N	227087	US20260008770, Example 110	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 275							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227087&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963221	336294183							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149239	C[C@H]1CCCN(Cc2cc(F)c3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)cc(OCF)n4)c(=O)c3c2)C1	InChI=1S/C29H33F2N7O2/c1-18-5-4-6-37(13-18)14-20-7-22-26(23(31)8-20)32-16-38(27(22)39)24-9-21(10-25(34-24)40-15-30)29(11-19(2)12-29)28-35-33-17-36(28)3/h7-10,16-19H,4-6,11-15H2,1-3H3	YGIDUNKJVPDSBO-UHFFFAOYSA-N	227088	US20260008770, Example 111	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227088&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963222	336294184							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149240	C[C@H]1CCCN(Cc2ccc3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)cc(OCF)n4)c(=O)c3c2)C1	InChI=1S/C29H34FN7O2/c1-19-5-4-8-36(14-19)15-21-6-7-24-23(9-21)27(38)37(17-31-24)25-10-22(11-26(33-25)39-16-30)29(12-20(2)13-29)28-34-32-18-35(28)3/h6-7,9-11,17-20H,4-5,8,12-16H2,1-3H3	QQIBXYUZHBDSIG-UHFFFAOYSA-N	227089	US20260008770, Example 112	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227089&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963223	336294185							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149241	[2H]c1nnc(C2(c3ccnc(-n4cnc5c(C(F)(F)F)cc(CN6CCC[C@H](C)C6)cc5c4=O)c3)CC(C)C2)n1C(F)F	InChI=1S/C29H30F5N7O/c1-17-4-3-7-39(13-17)14-19-8-21-24(22(9-19)29(32,33)34)36-15-40(25(21)42)23-10-20(5-6-35-23)28(11-18(2)12-28)26-38-37-16-41(26)27(30)31/h5-6,8-10,15-18,27H,3-4,7,11-14H2,1-2H3/i16D	ZJBMVKPHFUGRKY-QNLPYAOMSA-N	227090	US20260008770, Example 113	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227090&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963224	336294186							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149242	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](CF)C5)ccn4)c(=O)c3c2)C1	InChI=1S/C29H31F4N7O/c1-18-4-3-7-39(14-18)15-19-8-22-25(23(9-19)29(31,32)33)35-16-40(26(22)41)24-10-21(5-6-34-24)28(11-20(12-28)13-30)27-37-36-17-38(27)2/h5-6,8-10,16-18,20H,3-4,7,11-15H2,1-2H3	JANCVYSYUKJUIG-UHFFFAOYSA-N	227091	US20260008770, Example 114	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227091&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963225	336294187							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149243	COc1cc([C@]2(c3nncn3C)C[C@@H](C)C2)cc(-n2cnc3c(C(F)(F)F)cc(CN4CCC[C@H](C)C4)cc3c2=O)n1	InChI=1S/C30H34F3N7O2/c1-18-6-5-7-39(14-18)15-20-8-22-26(23(9-20)30(31,32)33)34-16-40(27(22)41)24-10-21(11-25(36-24)42-4)29(12-19(2)13-29)28-37-35-17-38(28)3/h8-11,16-19H,5-7,12-15H2,1-4H3	HXNIRMZHZFNJJK-UHFFFAOYSA-N	227092	US20260008770, Example 115	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227092&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963226	336294188							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149244	C=Cn1cnnc1C1(c2ccnc(-n3ncc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)CC(C)C1	InChI=1S/C30H32F3N7O/c1-4-39-18-35-37-28(39)29(13-20(3)14-29)22-7-8-34-26(12-22)40-27(41)23-10-21(17-38-9-5-6-19(2)16-38)11-25(30(31,32)33)24(23)15-36-40/h4,7-8,10-12,15,18-20H,1,5-6,9,13-14,16-17H2,2-3H3	VTXWWMFRMBFHMI-UHFFFAOYSA-N	227093	US20260008770, Example 116	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227093&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963227	336294189							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149245	CC1CC(c2cc(OC(F)F)nc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C30H32F5N7O2/c1-17-5-4-6-41(13-17)14-19-7-21-25(22(8-19)30(33,34)35)36-15-42(26(21)43)23-9-20(10-24(38-23)44-28(31)32)29(11-18(2)12-29)27-39-37-16-40(27)3/h7-10,15-18,28H,4-6,11-14H2,1-3H3	HNUBSIFTMCDRBL-UHFFFAOYSA-N	227094	US20260008770, Example 117	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227094&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963228	336294190							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149246	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cc(C5(c6nncn6C)CC6(CC6)C5)ccn4)c(=O)c3c2)C1	InChI=1S/C30H32F3N7O/c1-19-4-3-9-39(13-19)14-20-10-22-25(23(11-20)30(31,32)33)35-17-40(26(22)41)24-12-21(5-8-34-24)29(15-28(16-29)6-7-28)27-37-36-18-38(27)2/h5,8,10-12,17-19H,3-4,6-7,9,13-16H2,1-2H3	PKYQSVAOJVTZQH-UHFFFAOYSA-N	227095	US20260008770, Example 118	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 35							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227095&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963229	336294191							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149247	C[C@H]1CCCN(Cc2cc(C(F)(F)F)c3ncn(-c4cc([C@]5(c6nncn6C6CC6)C[C@@H](C)C5)ccn4)c(=O)c3c2)C1	InChI=1S/C31H34F3N7O/c1-19-4-3-9-39(15-19)16-21-10-24-27(25(11-21)31(32,33)34)36-17-41(28(24)42)26-12-22(7-8-35-26)30(13-20(2)14-30)29-38-37-18-40(29)23-5-6-23/h7-8,10-12,17-20,23H,3-6,9,13-16H2,1-2H3	ZEPLSBRQBWMJIJ-UHFFFAOYSA-N	227096	US20260008770, Example 119	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227096&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963230	336294192							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149248	Cn1cnnc1[C@]1(c2ccnc(-n3cnc4c(C(F)(F)F)cc(CN5CCC6(CCO6)C5)cc4c3=O)c2)C[C@H](C)C1	InChI=1S/C29H30F3N7O2/c1-18-12-28(13-18,26-36-35-17-37(26)2)20-3-6-33-23(11-20)39-16-34-24-21(25(39)40)9-19(10-22(24)29(30,31)32)14-38-7-4-27(15-38)5-8-41-27/h3,6,9-11,16-18H,4-5,7-8,12-15H2,1-2H3	OUAYZCXJOCBJOD-UHFFFAOYSA-N	227097	US20260008770, Example 120	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		 750							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227097&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963231	336294193							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149249	CC1CC(c2ccnc(-n3cnc4c(C(F)(F)F)cc(CN5CCC[C@H](C)C5)cc4c3=O)c2)(c2nncn2C)C1	InChI=1S/C29H32F3N7O/c1-18-5-4-8-38(14-18)15-20-9-22-25(23(10-20)29(30,31)32)34-16-39(26(22)40)24-11-21(6-7-33-24)28(12-19(2)13-28)27-36-35-17-37(27)3/h6-7,9-11,16-19H,4-5,8,12-15H2,1-3H3	XADIXHNVHSRGOY-UHFFFAOYSA-N	227098	US20260008770, Example 121	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227098&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963232	336294194							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149250	C[C@@H]1CN(Cc2ccc3ncn(-c4cc([C@]5(c6nncn6C)C[C@@H](C)C5)cc(OCF)n4)c(=O)c3c2)CCC1F	InChI=1S/C29H33F2N7O2/c1-18-11-29(12-18,28-35-33-17-36(28)3)21-9-25(34-26(10-21)40-15-30)38-16-32-24-5-4-20(8-22(24)27(38)39)14-37-7-6-23(31)19(2)13-37/h4-5,8-10,16-19,23H,6-7,11-15H2,1-3H3	ZEHXETVKAAAXDS-UHFFFAOYSA-N	227099	US20260008770, Example 123	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227099&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963233	336294195							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
149251	C[C@H]1CCCN(Cc2ccc3ncn(-c4cc([C@]5(c6nncn6C(F)F)C[C@@H](C)C5)cc(OCF)n4)c(=O)c3c2)C1	InChI=1S/C29H32F3N7O2/c1-18-4-3-7-37(13-18)14-20-5-6-23-22(8-20)26(40)38(16-33-23)24-9-21(10-25(35-24)41-15-30)29(11-19(2)12-29)27-36-34-17-39(27)28(31)32/h5-6,8-10,16-19,28H,3-4,7,11-15H2,1-2H3	WIUPWZSRPBGQBL-UHFFFAOYSA-N	227100	US20260008770, Example 124	E3 ubiquitin-protein ligase CBL-B	Homo sapiens		<20							US Patent		10.7270/Q2377FJ5			US20260008770	DING, X; LIU, X; LIU, Y; MENG, F; REN, F; WANG, Y; WANG, H	1/8/2026	5/21/2026	Insilico Medicine IP	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001030&target=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227100&enzyme=E3+ubiquitin-protein+ligase+CBL-B&column=ki&startPg=0&Increment=50&submit=Search			126963234	336294196							1	MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL	9FQJ,9FQI,9FQH,8QTK,8QTJ,8QTH,8QTG,8QNI,8QNH,8QNG,3VGO,5AXI,2LDR,2OOB,2OOA,2JNH	E3 ubiquitin-protein ligase CBL-B	CBLB_HUMAN	Q13191	A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5