BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 149264 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1CC[C@@H](N2CCOCC2)CC1 InChI=1S/C22H29F3N4O/c1-15(2)29-21(16-3-5-19(6-4-16)28-7-9-30-10-8-28)12-20(27-29)17-11-18(14-26-13-17)22(23,24)25/h11-16,19H,3-10H2,1-2H3 KJUHEKNZQWIJPS-UHFFFAOYSA-N 227110 4-((1s,4s)-4-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- hexyl)morpholine::US20260008775, Compound 1* 7-dehydrocholesterol reductase Homo sapiens 38.9 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227110&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963243 336294206 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149265 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1CC[C@H](N2CCOCC2)CC1 InChI=1S/C22H29F3N4O/c1-15(2)29-21(16-3-5-19(6-4-16)28-7-9-30-10-8-28)12-20(27-29)17-11-18(14-26-13-17)22(23,24)25/h11-16,19H,3-10H2,1-2H3 KJUHEKNZQWIJPS-UHFFFAOYSA-N 227112 4-((1r,4r)-4-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- hexyl)morpholine::US20260008775, Compound 2* 7-dehydrocholesterol reductase Homo sapiens 40.5 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227112&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963245 336294208 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149266 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@@H]1CC[C@@H](N2CCCOCC2)C1 InChI=1S/C21H28F3N5O/c1-14(2)29-20(15-4-6-17(12-15)28-8-3-10-30-11-9-28)26-19(27-29)16-5-7-18(25-13-16)21(22,23)24/h5,7,13-15,17H,3-4,6,8-12H2,1-2H3 KDJXBFRAXJKPAR-UHFFFAOYSA-N 227113 4-((1R,3R)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)-1,4-oxazepane::US20260008775, Compound 3 7-dehydrocholesterol reductase Homo sapiens 32.4 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227113&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963246 336294209 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149267 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@@H]1CC[C@H](N2CCCOCC2)C1 InChI=1S/C21H28F3N5O/c1-14(2)29-20(15-4-6-17(12-15)28-8-3-10-30-11-9-28)26-19(27-29)16-5-7-18(25-13-16)21(22,23)24/h5,7,13-15,17H,3-4,6,8-12H2,1-2H3 KDJXBFRAXJKPAR-UHFFFAOYSA-N 227114 4-((1S,3R)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)-1,4-oxazepane::US20260008775, Compound 4 7-dehydrocholesterol reductase Homo sapiens 8.28 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227114&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963247 336294210 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149268 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@H]1CC[C@H](N2CCCOCC2)C1 InChI=1S/C21H28F3N5O/c1-14(2)29-20(15-4-6-17(12-15)28-8-3-10-30-11-9-28)26-19(27-29)16-5-7-18(25-13-16)21(22,23)24/h5,7,13-15,17H,3-4,6,8-12H2,1-2H3 KDJXBFRAXJKPAR-UHFFFAOYSA-N 227115 4-((1S,3S)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)-1,4-oxazepane::US20260008775, Compound 5 7-dehydrocholesterol reductase Homo sapiens 52.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227115&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963248 336294211 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149269 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@H]1CC[C@@H](N2CCCOCC2)C1 InChI=1S/C21H28F3N5O/c1-14(2)29-20(15-4-6-17(12-15)28-8-3-10-30-11-9-28)26-19(27-29)16-5-7-18(25-13-16)21(22,23)24/h5,7,13-15,17H,3-4,6,8-12H2,1-2H3 KDJXBFRAXJKPAR-UHFFFAOYSA-N 227116 4-((1R,3S)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)-1,4-oxazepane::US20260008775, Compound 6 7-dehydrocholesterol reductase Homo sapiens 34.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227116&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963249 336294212 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149270 CCn1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@H]1CC[C@@H](N2CCCOCC2)CC1 InChI=1S/C21H28F3N5O/c1-2-29-20(15-4-7-17(8-5-15)28-10-3-12-30-13-11-28)26-19(27-29)16-6-9-18(25-14-16)21(22,23)24/h6,9,14-15,17H,2-5,7-8,10-13H2,1H3 CUVVCQQOVQGERL-UHFFFAOYSA-N 227117 4-((1s,4s)-4-(1-ethyl-3-(6- (trifluoromethyl)pyridin-3- yl)-1H-1,2,4-triazol-5-yl)- cyclohexyl)-1,4-oxazepane::US20260008775, Compound 7* 7-dehydrocholesterol reductase Homo sapiens 135 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227117&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963250 336294213 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149271 CCn1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@H]1CC[C@H](N2CCCOCC2)CC1 InChI=1S/C21H28F3N5O/c1-2-29-20(15-4-7-17(8-5-15)28-10-3-12-30-13-11-28)26-19(27-29)16-6-9-18(25-14-16)21(22,23)24/h6,9,14-15,17H,2-5,7-8,10-13H2,1H3 CUVVCQQOVQGERL-UHFFFAOYSA-N 227118 4-((1r,4r)-4-(1-ethyl-3-(6- (trifluoromethyl)pyridin-3- yl)-1H-1,2,4-triazol-5-yl)- cyclohexyl)-1,4-oxazepane::US20260008775, Compound 8* 7-dehydrocholesterol reductase Homo sapiens 38.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227118&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963251 336294214 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149272 FC(F)(F)c1cccc(-c2nc([C@H]3CC[C@H](N4CCCOCC4)C3)n(C3CC3)n2)n1 InChI=1S/C21H26F3N5O/c22-21(23,24)18-4-1-3-17(25-18)19-26-20(29(27-19)15-7-8-15)14-5-6-16(13-14)28-9-2-11-30-12-10-28/h1,3-4,14-16H,2,5-13H2 YMIQUTRWLRLVHU-UHFFFAOYSA-N 227119 4-((1S,3S)-3-(1-cycloprop- yl-3-(6-(trifluoromethyl)- pyridin-2-yl)-1H-1,2,4-tri- azol-5-yl)cyclopentyl)-1,4- oxazepane::US20260008775, Compound 9* 7-dehydrocholesterol reductase Homo sapiens 113 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227119&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963252 336294215 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149273 FC(F)(F)c1cccc(-c2nc([C@H]3CC[C@@H](N4CCCOCC4)C3)n(C3CC3)n2)n1 InChI=1S/C21H26F3N5O/c22-21(23,24)18-4-1-3-17(25-18)19-26-20(29(27-19)15-7-8-15)14-5-6-16(13-14)28-9-2-11-30-12-10-28/h1,3-4,14-16H,2,5-13H2 YMIQUTRWLRLVHU-UHFFFAOYSA-N 227120 4-((1R,3S)-3-(1-cycloprop- yl-3-(6-(trifluoromethyl)- pyridin-2-yl)-1H-1,2,4-tri- azol-5-yl)cyclopentyl)-1,4- oxazepane::US20260008775, Compound 10* 7-dehydrocholesterol reductase Homo sapiens 95.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227120&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963253 336294216 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149274 FC(F)(F)c1cccc(-c2nc([C@@H]3CC[C@@H](N4CCCOCC4)C3)n(C3CC3)n2)n1 InChI=1S/C21H26F3N5O/c22-21(23,24)18-4-1-3-17(25-18)19-26-20(29(27-19)15-7-8-15)14-5-6-16(13-14)28-9-2-11-30-12-10-28/h1,3-4,14-16H,2,5-13H2 YMIQUTRWLRLVHU-UHFFFAOYSA-N 227121 4-((1R,3R)-3-(1-cyclopropyl- 3-(6-(trifluoromethyl)pyridin- 2-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)-1,4-oxazepane::US20260008775, Compound 11* 7-dehydrocholesterol reductase Homo sapiens 134 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227121&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963254 336294217 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149275 FC(F)(F)c1cccc(-c2nc([C@@H]3CC[C@H](N4CCCOCC4)C3)n(C3CC3)n2)n1 InChI=1S/C21H26F3N5O/c22-21(23,24)18-4-1-3-17(25-18)19-26-20(29(27-19)15-7-8-15)14-5-6-16(13-14)28-9-2-11-30-12-10-28/h1,3-4,14-16H,2,5-13H2 YMIQUTRWLRLVHU-UHFFFAOYSA-N 227122 4-((1S,3R)-3-(1-cyclopropyl- 3-(6-(trifluoromethyl)pyridin- 2-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)-1,4-oxazepane::US20260008775, Compound 12* 7-dehydrocholesterol reductase Homo sapiens 120 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227122&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963255 336294218 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149276 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCOCC3)C[C@@H]21 InChI=1S/C22H27F3N4O/c1-13(2)29-21(19-17-11-16(12-18(17)19)28-6-8-30-9-7-28)26-20(27-29)14-4-3-5-15(10-14)22(23,24)25/h3-5,10,13,16-19H,6-9,11-12H2,1-2H3 XTUOAWIOAQEOLG-UHFFFAOYSA-N 227123 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(3-(trifluorometh- yl)phenyl)-1H-1,2,4-triazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)morpholine::US20260008775, Compound 19* 7-dehydrocholesterol reductase Homo sapiens 9.93 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227123&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963256 336294219 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149277 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)nc1[C@@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C21H27F3N4O/c1-14(2)28-20(16-6-7-18(13-16)27-8-10-29-11-9-27)25-19(26-28)15-4-3-5-17(12-15)21(22,23)24/h3-5,12,14,16,18H,6-11,13H2,1-2H3 SLIDTQRTHZOXOO-UHFFFAOYSA-N 227124 4-((1R,3R)-3-(1-isopropyl-3- (3-(trifluoromethyl)phenyl)- 1H-1,2,4-triazol-5-yl)cyclo- pentyl)morpholine::US20260008775, Compound 21* 7-dehydrocholesterol reductase Homo sapiens 27.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227124&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963257 336294220 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149278 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)nc1[C@@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C21H27F3N4O/c1-14(2)28-20(16-6-7-18(13-16)27-8-10-29-11-9-27)25-19(26-28)15-4-3-5-17(12-15)21(22,23)24/h3-5,12,14,16,18H,6-11,13H2,1-2H3 SLIDTQRTHZOXOO-UHFFFAOYSA-N 227125 4-((1S,3R)-3-(1-isopropyl-3- (3-(trifluoromethyl)phenyl)- 1H-1,2,4-triazol-5-yl)cyclo- pentyl)morpholine::US20260008775, Compound 22* 7-dehydrocholesterol reductase Homo sapiens 10.9 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227125&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963258 336294221 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149279 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)nc1[C@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C21H27F3N4O/c1-14(2)28-20(16-6-7-18(13-16)27-8-10-29-11-9-27)25-19(26-28)15-4-3-5-17(12-15)21(22,23)24/h3-5,12,14,16,18H,6-11,13H2,1-2H3 SLIDTQRTHZOXOO-UHFFFAOYSA-N 227126 4-((1S,3S)-3-(1-isopropyl-3- (3-(trifluoromethyl)phenyl)- 1H-1,2,4-triazol-5-yl)cyclo- pentyl)morpholine::US20260008775, Compound 23* 7-dehydrocholesterol reductase Homo sapiens 15.5 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227126&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963259 336294222 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149280 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)nc1[C@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C21H27F3N4O/c1-14(2)28-20(16-6-7-18(13-16)27-8-10-29-11-9-27)25-19(26-28)15-4-3-5-17(12-15)21(22,23)24/h3-5,12,14,16,18H,6-11,13H2,1-2H3 SLIDTQRTHZOXOO-UHFFFAOYSA-N 227127 4-((1R,3S)-3-(1-isopropyl-3- (3-(trifluoromethyl)phenyl)- 1H-1,2,4-triazol-5-yl)cyclo- pentyl)morpholine::US20260008775, Compound 24* 7-dehydrocholesterol reductase Homo sapiens 8.90 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227127&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963260 336294223 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149281 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)nc1[C@@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C20H26F3N5O/c1-13(2)28-19(14-6-7-15(12-14)27-8-10-29-11-9-27)25-18(26-28)16-4-3-5-17(24-16)20(21,22)23/h3-5,13-15H,6-12H2,1-2H3 ZPNSZKSQNNHGEL-UHFFFAOYSA-N 227128 4-((1S,3R)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 2-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 26* 7-dehydrocholesterol reductase Homo sapiens 22.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227128&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963261 336294224 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149282 CC(C)n1nc(-c2cc(C(F)(F)F)ccn2)nc1[C@@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C20H26F3N5O/c1-13(2)28-19(14-3-4-16(11-14)27-7-9-29-10-8-27)25-18(26-28)17-12-15(5-6-24-17)20(21,22)23/h5-6,12-14,16H,3-4,7-11H2,1-2H3 DMZROYKWOQRRKZ-UHFFFAOYSA-N 227129 4-((1S,3R)-3-(1-isopropyl-3- (4-(trifluoromethyl)pyridin- 2-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 28* 7-dehydrocholesterol reductase Homo sapiens 29.9 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227129&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963262 336294225 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149283 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-14(2)30-21(11-20(28-30)15-8-16(13-27-12-15)23(24,25)26)22-18-9-17(10-19(18)22)29-4-3-6-31-7-5-29/h8,11-14,17-19,22H,3-7,9-10H2,1-2H3 YWJWEOLYECROGK-UHFFFAOYSA-N 227130 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(5-(trifluorometh- yl)pyridin-3-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-1,4-oxazepane::US20260008775, Compound 29* 7-dehydrocholesterol reductase Homo sapiens 20.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227130&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963263 336294226 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149284 CCn1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H27F3N4O/c1-2-29-20(11-19(27-29)14-8-15(13-26-12-14)22(23,24)25)21-17-9-16(10-18(17)21)28-4-3-6-30-7-5-28/h8,11-13,16-18,21H,2-7,9-10H2,1H3 GBLXRRBNFVMUHM-UHFFFAOYSA-N 227131 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(5-(trifluorometh- yl)pyridin-3-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-1,4-oxazepane::US20260008775, Compound 30* 7-dehydrocholesterol reductase Homo sapiens 32.5 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227131&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126962693 336294227 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149285 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOCC3)C[C@@H]21 InChI=1S/C22H27F3N4O/c1-13(2)29-19(12-18(27-29)17-4-3-5-20(26-17)22(23,24)25)21-15-10-14(11-16(15)21)28-6-8-30-9-7-28/h3-5,12-16,21H,6-11H2,1-2H3 RXNKHJBZRQSZBQ-UHFFFAOYSA-N 227132 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(6-(trifluorometh- yl)pyridin-2-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)morpholine::US20260008775, Compound 31 7-dehydrocholesterol reductase Homo sapiens 100.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227132&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963264 336294228 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149286 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@H](N3CCOCC3)C[C@@H]21 InChI=1S/C22H27F3N4O/c1-13(2)29-19(12-18(27-29)17-4-3-5-20(26-17)22(23,24)25)21-15-10-14(11-16(15)21)28-6-8-30-9-7-28/h3-5,12-16,21H,6-11H2,1-2H3 RXNKHJBZRQSZBQ-UHFFFAOYSA-N 227133 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(6-(trifluorometh- yl)pyridin-2-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)morpholine::US20260008775, Compound 32 7-dehydrocholesterol reductase Homo sapiens 34.5 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227133 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227133&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963265 336294229 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149287 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOC(C)(C)C3)C[C@@H]21 InChI=1S/C24H31F3N4O/c1-14(2)31-20(12-19(29-31)18-6-5-7-21(28-18)24(25,26)27)22-16-10-15(11-17(16)22)30-8-9-32-23(3,4)13-30/h5-7,12,14-17,22H,8-11,13H2,1-4H3 ZUCCBRFNNTZRSM-UHFFFAOYSA-N 227134 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(5-(trifluorometh- yl)pyridin-3-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-2,2-dimethylmorpholine::US20260008775, Compound 33 7-dehydrocholesterol reductase Homo sapiens 19.4 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227134&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963266 336294230 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149288 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@H](N3CCOC(C)(C)C3)C[C@@H]21 InChI=1S/C24H31F3N4O/c1-14(2)31-20(12-19(29-31)18-6-5-7-21(28-18)24(25,26)27)22-16-10-15(11-17(16)22)30-8-9-32-23(3,4)13-30/h5-7,12,14-17,22H,8-11,13H2,1-4H3 ZUCCBRFNNTZRSM-UHFFFAOYSA-N 227135 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(5-(trifluorometh- yl)pyridin-3-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-2,2-dimethylmorpholine::US20260008775, Compound 34 7-dehydrocholesterol reductase Homo sapiens 34.5 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227135 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227135&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963267 336294231 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149289 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3C[C@H]4C[C@@H]3CO4)C[C@@H]21 InChI=1S/C23H27F3N4O/c1-12(2)30-21(7-20(28-30)13-3-14(9-27-8-13)23(24,25)26)22-18-5-15(6-19(18)22)29-10-17-4-16(29)11-31-17/h3,7-9,12,15-19,22H,4-6,10-11H2,1-2H3 YMRDWBGAPVIHEH-UHFFFAOYSA-N 227136 (1R,4R)-5-((1R,3s,5S,6R)-6- (1-isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-2-oxa-5-azabi- cyclo[2.2.1]heptane::US20260008775, Compound 35* 7-dehydrocholesterol reductase Homo sapiens 112 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227136&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963268 336294232 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149290 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3C[C@@H]4C[C@H]3CO4)C[C@@H]21 InChI=1S/C23H27F3N4O/c1-12(2)30-21(7-20(28-30)13-3-14(9-27-8-13)23(24,25)26)22-18-5-15(6-19(18)22)29-10-17-4-16(29)11-31-17/h3,7-9,12,15-19,22H,4-6,10-11H2,1-2H3 YMRDWBGAPVIHEH-UHFFFAOYSA-N 227137 (1S,4R)-5-((1R,3s,5S,6R)-6- (1-isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-2-oxa-5-azabi- cyclo[2.2.1]heptane::US20260008775, Compound 36* 7-dehydrocholesterol reductase Homo sapiens 211 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227137&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963269 336294233 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149291 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3C[C@H]4C[C@@H]3CO4)C[C@@H]21 InChI=1S/C23H27F3N4O/c1-12(2)30-21(7-20(28-30)13-3-14(9-27-8-13)23(24,25)26)22-18-5-15(6-19(18)22)29-10-17-4-16(29)11-31-17/h3,7-9,12,15-19,22H,4-6,10-11H2,1-2H3 YMRDWBGAPVIHEH-UHFFFAOYSA-N 227138 (1R,4R)-5-((1R,3r,5S,6R)-6- (1-isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-2-oxa-5-azabi- cyclo[2.2.1]heptane::US20260008775, Compound 37* 7-dehydrocholesterol reductase Homo sapiens 33.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227138&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963270 336294234 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149292 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3C[C@@H]4C[C@H]3CO4)C[C@@H]21 InChI=1S/C23H27F3N4O/c1-12(2)30-21(7-20(28-30)13-3-14(9-27-8-13)23(24,25)26)22-18-5-15(6-19(18)22)29-10-17-4-16(29)11-31-17/h3,7-9,12,15-19,22H,4-6,10-11H2,1-2H3 YMRDWBGAPVIHEH-UHFFFAOYSA-N 227139 (1S,4R)-5-((1R,3r,5S,6R)-6- (1-isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-2-oxa-5-azabi- cyclo[2.2.1]heptane::US20260008775, Compound 38* 7-dehydrocholesterol reductase Homo sapiens 47.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227139&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963271 336294235 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149293 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCO[C@@H](C)C3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-21(9-20(28-30)15-6-16(11-27-10-15)23(24,25)26)22-18-7-17(8-19(18)22)29-4-5-31-14(3)12-29/h6,9-11,13-14,17-19,22H,4-5,7-8,12H2,1-3H3 PIWFUSUXZQEBHK-UHFFFAOYSA-N 227140 (S)-4-((1R,3s,5S,6S)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-2-methylmor- pholine::US20260008775, Compound 39* 7-dehydrocholesterol reductase Homo sapiens 771 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227140&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963266 336294236 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149294 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCO[C@H](C)C3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-21(9-20(28-30)15-6-16(11-27-10-15)23(24,25)26)22-18-7-17(8-19(18)22)29-4-5-31-14(3)12-29/h6,9-11,13-14,17-19,22H,4-5,7-8,12H2,1-3H3 PIWFUSUXZQEBHK-UHFFFAOYSA-N 227141 (R)-4-((1R,3s,5S,6R)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-2-methylmor- pholine::US20260008775, Compound 40* 7-dehydrocholesterol reductase Homo sapiens 111 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227141&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126962693 336294237 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149295 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCO[C@@H](C)C3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-21(9-20(28-30)15-6-16(11-27-10-15)23(24,25)26)22-18-7-17(8-19(18)22)29-4-5-31-14(3)12-29/h6,9-11,13-14,17-19,22H,4-5,7-8,12H2,1-3H3 PIWFUSUXZQEBHK-UHFFFAOYSA-N 227142 (S)-4-((1R,3r,5S,6S)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-2-methylmor- pholine::US20260008775, Compound 41* 7-dehydrocholesterol reductase Homo sapiens 22.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227142&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963272 336294238 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149296 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCO[C@H](C)C3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-21(9-20(28-30)15-6-16(11-27-10-15)23(24,25)26)22-18-7-17(8-19(18)22)29-4-5-31-14(3)12-29/h6,9-11,13-14,17-19,22H,4-5,7-8,12H2,1-3H3 PIWFUSUXZQEBHK-UHFFFAOYSA-N 227143 (R)-4-((1R,3r,5S,6R)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-2-methylmor- pholine::US20260008775, Compound 42* 7-dehydrocholesterol reductase Homo sapiens 23.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227143&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963273 336294239 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149297 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CC(N3CCOC[C@@H]3C)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-21(9-20(28-30)15-6-16(11-27-10-15)23(24,25)26)22-18-7-17(8-19(18)22)29-4-5-31-12-14(29)3/h6,9-11,13-14,17-19,22H,4-5,7-8,12H2,1-3H3 XYZQWYVDZBQCOZ-UHFFFAOYSA-N 227144 (S)-4-((1R,3s,5S,6S)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 43* 7-dehydrocholesterol reductase Homo sapiens 65.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227144&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126962699 336294240 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149298 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2CC(N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-21(9-20(28-30)15-6-16(11-27-10-15)23(24,25)26)22-18-7-17(8-19(18)22)29-4-5-31-12-14(29)3/h6,9-11,13-14,17-19,22H,4-5,7-8,12H2,1-3H3 XYZQWYVDZBQCOZ-UHFFFAOYSA-N 227145 (R)-4-((1R,3s,5S,6R)-6-(1- isopropyl-3-(5-(trifluorometh- yl)pyridin-3-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-3-methylmorpholine::US20260008775, Compound 44* 7-dehydrocholesterol reductase Homo sapiens 65.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227145&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963274 336294241 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149299 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@@H]3C)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-21(9-20(28-30)15-6-16(11-27-10-15)23(24,25)26)22-18-7-17(8-19(18)22)29-4-5-31-12-14(29)3/h6,9-11,13-14,17-19,22H,4-5,7-8,12H2,1-3H3 XYZQWYVDZBQCOZ-UHFFFAOYSA-N 227146 (S)-4-((1R,3r,5S,6S)-6-(1- isopropyl-3-(5-(trifluorometh- yl)pyridin-3-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-3-methylmorpholine::US20260008775, Compound 45* 7-dehydrocholesterol reductase Homo sapiens 53.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227146&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126962665 336294242 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149300 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-21(9-20(28-30)15-6-16(11-27-10-15)23(24,25)26)22-18-7-17(8-19(18)22)29-4-5-31-12-14(29)3/h6,9-11,13-14,17-19,22H,4-5,7-8,12H2,1-3H3 XYZQWYVDZBQCOZ-UHFFFAOYSA-N 227147 (R)-4-((1R,3r,5S,6R)-6-(1- isopropyl-3-(5-(trifluorometh- yl)pyridin-3-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-3-methylmorpholine::US20260008775, Compound 46* 7-dehydrocholesterol reductase Homo sapiens 34.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227147&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963275 336294243 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149301 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-14(2)30-20(12-19(28-30)15-4-5-21(27-13-15)23(24,25)26)22-17-10-16(11-18(17)22)29-6-3-8-31-9-7-29/h4-5,12-14,16-18,22H,3,6-11H2,1-2H3 QITDCRBYKRXDON-UHFFFAOYSA-N 227148 4-((1R,3S,5S,6R)-6-(1-iso- propyl-3-(6-(trifluorometh- yl)pyridin-3-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-1,4-oxazepane::US20260008775, Compound 47 7-dehydrocholesterol reductase Homo sapiens 43.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227148&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963276 336294244 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149302 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-14(2)30-20(12-19(28-30)15-4-5-21(27-13-15)23(24,25)26)22-17-10-16(11-18(17)22)29-6-3-8-31-9-7-29/h4-5,12-14,16-18,22H,3,6-11H2,1-2H3 QITDCRBYKRXDON-UHFFFAOYSA-N 227149 4-((1R,3R,5S,6R)-6-(1-iso- propyl-3-(6-(trifluorometh- yl)pyridin-3-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-1,4-oxazepane::US20260008775, Compound 48 7-dehydrocholesterol reductase Homo sapiens 18.4 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227149&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963277 336294245 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149303 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-14(2)30-20(13-19(28-30)18-5-3-6-21(27-18)23(24,25)26)22-16-11-15(12-17(16)22)29-7-4-9-31-10-8-29/h3,5-6,13-17,22H,4,7-12H2,1-2H3 RARKMBITQQSYDC-UHFFFAOYSA-N 227150 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(6-(trifluorometh- yl)pyridin-2-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-1,4-oxazepane::US20260008775, Compound 49 7-dehydrocholesterol reductase Homo sapiens 53.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227150&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963278 336294246 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149304 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-14(2)30-20(13-19(28-30)18-5-3-6-21(27-18)23(24,25)26)22-16-11-15(12-17(16)22)29-7-4-9-31-10-8-29/h3,5-6,13-17,22H,4,7-12H2,1-2H3 RARKMBITQQSYDC-UHFFFAOYSA-N 227151 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(6-(trifluorometh- yl)pyridin-2-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-1,4-oxazepane::US20260008775, Compound 50 7-dehydrocholesterol reductase Homo sapiens 21.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227151 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227151&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 118497108 336294247 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149305 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-13(2)30-21(27-20(28-30)14-8-15(12-26-11-14)22(23,24)25)19-17-9-16(10-18(17)19)29-4-3-6-31-7-5-29/h8,11-13,16-19H,3-7,9-10H2,1-2H3 UXDVDVBUKNKJSW-UHFFFAOYSA-N 227152 4-((1R,3R,5S,6R)-6-(1-iso- propyl-3-(5-(trifluorometh- yl)pyridin-3-yl)-1H-1,2,4- triazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-1,4-oxazepane::US20260008775, Compound 51 7-dehydrocholesterol reductase Homo sapiens 358 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227152 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227152&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126962685 336294248 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149306 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-13(2)30-21(27-20(28-30)14-8-15(12-26-11-14)22(23,24)25)19-17-9-16(10-18(17)19)29-4-3-6-31-7-5-29/h8,11-13,16-19H,3-7,9-10H2,1-2H3 UXDVDVBUKNKJSW-UHFFFAOYSA-N 227153 4-((1R,3S,5S,6R)-6-(1-iso- propyl-3-(5-(trifluorometh- yl)pyridin-3-yl)-1H-1,2,4- triazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-1,4-oxazepane::US20260008775, Compound 52 7-dehydrocholesterol reductase Homo sapiens 18.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227153&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 126963279 336294249 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149307 CCn1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H27F3N4O/c1-2-29-20(11-19(27-29)14-8-15(13-26-12-14)22(23,24)25)21-17-9-16(10-18(17)21)28-4-3-6-30-7-5-28/h8,11-13,16-18,21H,2-7,9-10H2,1H3 GBLXRRBNFVMUHM-UHFFFAOYSA-N 229594 4-((1R,3s,5S,6r)-6-(1-ethyl- 3-(5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-1,4- oxazepane::US20260008775, Compound 53 7-dehydrocholesterol reductase Homo sapiens 12.5 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229594&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search Z78 127053837 336949079 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149308 CCn1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H27F3N4O/c1-2-29-20(11-19(27-29)14-8-15(13-26-12-14)22(23,24)25)21-17-9-16(10-18(17)21)28-4-3-6-30-7-5-28/h8,11-13,16-18,21H,2-7,9-10H2,1H3 GBLXRRBNFVMUHM-UHFFFAOYSA-N 229636 4-((1R,3r,5S,6r)-6-(1-ethyl- 3-(5-(trifluoromethyl)pyr- idin-3-yl)-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 54 7-dehydrocholesterol reductase Homo sapiens 10.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229636 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229636&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372206 336949121 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149309 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C21H27F3N4O/c1-14(2)28-20(15-3-4-18(10-15)27-5-7-29-8-6-27)11-19(26-28)16-9-17(13-25-12-16)21(22,23)24/h9,11-15,18H,3-8,10H2,1-2H3 GYPHICWXLMACJX-UHFFFAOYSA-N 229637 4-((1S,3S)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)morpholine::US20260008775, Compound 58* 7-dehydrocholesterol reductase Homo sapiens 26.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229637 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229637&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372207 336949122 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149310 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C21H27F3N4O/c1-14(2)28-20(15-3-4-18(10-15)27-5-7-29-8-6-27)11-19(26-28)16-9-17(13-25-12-16)21(22,23)24/h9,11-15,18H,3-8,10H2,1-2H3 GYPHICWXLMACJX-UHFFFAOYSA-N 229638 4-((1R,3R)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)morpholine::US20260008775, Compound 59* 7-dehydrocholesterol reductase Homo sapiens 73.4 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229638 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229638&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372208 336949123 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149311 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C21H27F3N4O/c1-14(2)28-20(15-3-4-18(10-15)27-5-7-29-8-6-27)11-19(26-28)16-9-17(13-25-12-16)21(22,23)24/h9,11-15,18H,3-8,10H2,1-2H3 GYPHICWXLMACJX-UHFFFAOYSA-N 229639 4-((1R,3S)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)morpholine::US20260008775, Compound 60* 7-dehydrocholesterol reductase Homo sapiens 19.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229639 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229639&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372209 336949124 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149312 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C21H27F3N4O/c1-14(2)28-20(15-3-4-18(10-15)27-5-7-29-8-6-27)11-19(26-28)16-9-17(13-25-12-16)21(22,23)24/h9,11-15,18H,3-8,10H2,1-2H3 GYPHICWXLMACJX-UHFFFAOYSA-N 229640 4-((1S,3R)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)morpholine::US20260008775, Compound 61* 7-dehydrocholesterol reductase Homo sapiens 69.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229640 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229640&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372210 336949125 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149313 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@@H]1CC[C@H](N2CCCOCC2)C1 InChI=1S/C22H29F3N4O/c1-15(2)29-21(16-4-5-19(11-16)28-6-3-8-30-9-7-28)12-20(27-29)17-10-18(14-26-13-17)22(23,24)25/h10,12-16,19H,3-9,11H2,1-2H3 RZINPYLPUMUGET-UHFFFAOYSA-N 229641 4-((1S,3S)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)-1,4-oxazepane::US20260008775, Compound 62* 7-dehydrocholesterol reductase Homo sapiens 13.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229641 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229641&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372211 336949126 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149314 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1CC[C@H](N2CCCOCC2)C1 InChI=1S/C22H29F3N4O/c1-15(2)29-21(16-4-5-19(11-16)28-6-3-8-30-9-7-28)12-20(27-29)17-10-18(14-26-13-17)22(23,24)25/h10,12-16,19H,3-9,11H2,1-2H3 RZINPYLPUMUGET-UHFFFAOYSA-N 229642 4-((1R,3R)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)-1,4-oxazepane::US20260008775, Compound 63* 7-dehydrocholesterol reductase Homo sapiens 14.4 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229642 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229642&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372339 336949127 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149315 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1CC[C@@H](N2CCCOCC2)C1 InChI=1S/C22H29F3N4O/c1-15(2)29-21(16-4-5-19(11-16)28-6-3-8-30-9-7-28)12-20(27-29)17-10-18(14-26-13-17)22(23,24)25/h10,12-16,19H,3-9,11H2,1-2H3 RZINPYLPUMUGET-UHFFFAOYSA-N 229643 4-((1R,3S)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)-1,4-oxazepane::US20260008775, Compound 64* 7-dehydrocholesterol reductase Homo sapiens 15.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229643 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229643&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372340 336949128 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149316 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@@H]1CC[C@@H](N2CCCOCC2)C1 InChI=1S/C22H29F3N4O/c1-15(2)29-21(16-4-5-19(11-16)28-6-3-8-30-9-7-28)12-20(27-29)17-10-18(14-26-13-17)22(23,24)25/h10,12-16,19H,3-9,11H2,1-2H3 RZINPYLPUMUGET-UHFFFAOYSA-N 229644 4-((1S,3R)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)-1,4-oxazepane::US20260008775, Compound 65* 7-dehydrocholesterol reductase Homo sapiens 28.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229644 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229644&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372341 336949129 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149317 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@@H]3C)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-22(27-21(28-30)15-5-4-6-16(9-15)23(24,25)26)20-18-10-17(11-19(18)20)29-7-8-31-12-14(29)3/h4-6,9,13-14,17-20H,7-8,10-12H2,1-3H3 LEBUYGAOQHGDPY-UHFFFAOYSA-N 229645 (S)-4-((1R,3r,5S,6S)-6-(1- isopropyl-3-(3-(trifluoro- methyl)phenyl)-1H-1,2,4- triazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 66 7-dehydrocholesterol reductase Homo sapiens 50.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229645 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229645&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372342 336949130 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149318 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@@H]3C)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-22(27-21(28-30)15-5-4-6-16(9-15)23(24,25)26)20-18-10-17(11-19(18)20)29-7-8-31-12-14(29)3/h4-6,9,13-14,17-20H,7-8,10-12H2,1-3H3 LEBUYGAOQHGDPY-UHFFFAOYSA-N 229646 (S)-4-((1R,3s,5S,6S)-6-(1- isopropyl-3-(3-(trifluoro- methyl)phenyl)-1H-1,2,4- triazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 67 7-dehydrocholesterol reductase Homo sapiens 50.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229646 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229646&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search G2W 53348208 336949131 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149319 CC(C)n1nc(-c2cncc(OC(F)F)c2)nc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H29F2N5O2/c1-13(2)29-21(26-20(27-29)14-8-16(12-25-11-14)31-22(23)24)19-17-9-15(10-18(17)19)28-4-3-6-30-7-5-28/h8,11-13,15,17-19,22H,3-7,9-10H2,1-2H3 NBUOONMNPQZACG-UHFFFAOYSA-N 229647 4-((1R,3s,5S,6r)-6-(3-(5- (difluoromethoxy)pyridin-3- yl)-1-isopropyl-1H-1,2,4- triazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-1,4-oxazepane::US20260008775, Compound 68 7-dehydrocholesterol reductase Homo sapiens 119 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229647 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229647&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372343 336949132 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149320 CC(C)n1nc(-c2cncc(OC(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H29F2N5O2/c1-13(2)29-21(26-20(27-29)14-8-16(12-25-11-14)31-22(23)24)19-17-9-15(10-18(17)19)28-4-3-6-30-7-5-28/h8,11-13,15,17-19,22H,3-7,9-10H2,1-2H3 NBUOONMNPQZACG-UHFFFAOYSA-N 229648 4-((1R,3r,5S,6r)-6-(3-(5- (difluoromethoxy)pyridin-3- yl)-1-isopropyl-1H-1,2,4- triazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-1,4-oxazepane::US20260008775, Compound 69 7-dehydrocholesterol reductase Homo sapiens 27.9 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229648 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229648&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372344 336949133 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149321 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-22(27-21(28-30)15-5-4-6-16(9-15)23(24,25)26)20-18-10-17(11-19(18)20)29-7-8-31-12-14(29)3/h4-6,9,13-14,17-20H,7-8,10-12H2,1-3H3 LEBUYGAOQHGDPY-UHFFFAOYSA-N 229649 (R)-4-((1R,3r,5S,6S)-6-(1- isopropyl-3-(3-(trifluoro- methyl)phenyl)-1H-1,2,4- triazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 70* 7-dehydrocholesterol reductase Homo sapiens 8.76 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229649 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229649&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372476 336949134 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149322 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-13(2)30-22(27-21(28-30)15-5-4-6-16(9-15)23(24,25)26)20-18-10-17(11-19(18)20)29-7-8-31-12-14(29)3/h4-6,9,13-14,17-20H,7-8,10-12H2,1-3H3 LEBUYGAOQHGDPY-UHFFFAOYSA-N 229650 (R)-4-((1R,3s,5S,6S)-6-(1- isopropyl-3-(3-(trifluoro- methyl)phenyl)-1H-1,2,4- triazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 71* 7-dehydrocholesterol reductase Homo sapiens 29.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229650 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229650&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372477 336949135 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149323 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)nc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-21(27-20(28-30)17-5-4-6-18(26-17)22(23,24)25)19-15-9-14(10-16(15)19)29-7-8-31-11-13(29)3/h4-6,12-16,19H,7-11H2,1-3H3 WYYRELUXJBYGOJ-UHFFFAOYSA-N 229651 (R)-4-((1R,3s,5S,6R)-6-(1- isopropyl-3-(6-(trifluoro- methyl)pyridin-2-yl)-1H- 1,2,4-triazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-3-methyl- morpholine::US20260008775, Compound 72 7-dehydrocholesterol reductase Homo sapiens 1170 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229651 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229651&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372478 336949136 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149324 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)nc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-21(27-20(28-30)17-5-4-6-18(26-17)22(23,24)25)19-15-9-14(10-16(15)19)29-7-8-31-11-13(29)3/h4-6,12-16,19H,7-11H2,1-3H3 WYYRELUXJBYGOJ-UHFFFAOYSA-N 229652 (R)-4-((1R,3r,5S,6R)-6-(1- isopropyl-3-(6-(trifluoro- methyl)pyridin-2-yl)-1H- 1,2,4-triazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-3-methyl- morpholine::US20260008775, Compound 73 7-dehydrocholesterol reductase Homo sapiens 109 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229652 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229652&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372479 336949137 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149325 CC(C)n1nc(-c2cccc(OC(F)F)c2)nc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H30F2N4O2/c1-14(2)29-22(26-21(27-29)15-5-3-6-17(11-15)31-23(24)25)20-18-12-16(13-19(18)20)28-7-4-9-30-10-8-28/h3,5-6,11,14,16,18-20,23H,4,7-10,12-13H2,1-2H3 HGHCPGOGMLJWKX-UHFFFAOYSA-N 229653 4-((1R,3s,5S,6r)-6-(3-(3- (difluoromethoxy)phenyl)-1- isopropyl-1H-1,2,4-triazol-5- yl)bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 74 7-dehydrocholesterol reductase Homo sapiens 37.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229653 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229653&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371691 336949138 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149326 CC(C)n1nc(-c2cccc(OC(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H30F2N4O2/c1-14(2)29-22(26-21(27-29)15-5-3-6-17(11-15)31-23(24)25)20-18-12-16(13-19(18)20)28-7-4-9-30-10-8-28/h3,5-6,11,14,16,18-20,23H,4,7-10,12-13H2,1-2H3 HGHCPGOGMLJWKX-UHFFFAOYSA-N 229654 4-((1R,3r,5S,6r)-6-(3-(3- (difluoromethoxy)phenyl)-1- isopropyl-1H-1,2,4-triazol-5- yl)bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 75 7-dehydrocholesterol reductase Homo sapiens 12.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229654 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229654&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372480 336949139 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149327 CC(C)n1nc(-c2cccc(OC(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H30F2N4O2/c1-13(2)29-22(26-21(27-29)15-5-4-6-17(9-15)31-23(24)25)20-18-10-16(11-19(18)20)28-7-8-30-12-14(28)3/h4-6,9,13-14,16,18-20,23H,7-8,10-12H2,1-3H3 UAFXYYVFLQCXJE-UHFFFAOYSA-N 229655 (R)-4-((1R,3r,5S,6R)-6-(3- (3-(difluoromethoxy)phenyl)- 1-isopropyl-1H-1,2,4-triazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-3-methylmorpholine::US20260008775, Compound 76 7-dehydrocholesterol reductase Homo sapiens 15.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229655 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229655&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372481 336949140 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149328 CC(C)n1nc(-c2cccc(OC(F)F)c2)nc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H30F2N4O2/c1-13(2)29-22(26-21(27-29)15-5-4-6-17(9-15)31-23(24)25)20-18-10-16(11-19(18)20)28-7-8-30-12-14(28)3/h4-6,9,13-14,16,18-20,23H,7-8,10-12H2,1-3H3 UAFXYYVFLQCXJE-UHFFFAOYSA-N 229656 (R)-4-((1R,3s,5S,6R)-6-(3- (3-(difluoromethoxy)phenyl)- 1-isopropyl-1H-1,2,4-triazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)-3-methylmorpholine::US20260008775, Compound 77 7-dehydrocholesterol reductase Homo sapiens 129 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229656 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229656&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372607 336949141 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149329 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)nc1[C@H]1CC[C@H](N2CCOC[C@H]2C)CC1 InChI=1S/C22H30F3N5O/c1-14(2)30-21(16-7-9-17(10-8-16)29-11-12-31-13-15(29)3)27-20(28-30)18-5-4-6-19(26-18)22(23,24)25/h4-6,14-17H,7-13H2,1-3H3 AGYSPSZARIZZBI-UHFFFAOYSA-N 229657 (R)-4-((1R,4R)-4-(1-isoprop- yl-3-(6-(trifluoromethyl)pyr- idin-2-yl)-1H-1,2,4-triazol-5- yl)cyclohexyl)-3-methylmor- pholine::US20260008775, Compound 80* 7-dehydrocholesterol reductase Homo sapiens 528 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229657 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229657&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372608 336949142 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149330 COCCN1CCN([C@@H]2CC[C@@H](c3nc(-c4ccc(C(F)(F)F)nc4)nn3C(C)C)C2)CC1 InChI=1S/C23H33F3N6O/c1-16(2)32-22(28-21(29-32)18-5-7-20(27-15-18)23(24,25)26)17-4-6-19(14-17)31-10-8-30(9-11-31)12-13-33-3/h5,7,15-17,19H,4,6,8-14H2,1-3H3 SRMCQGRFCXLBGZ-UHFFFAOYSA-N 229658 1-((1R,3R)-3-(1-isopropyl- 3-(6-(trifluoromethyl)pyr- idin-3-yl)-1H-1,2,4-triazol- 5-yl)cyclopentyl)-4-(2-meth- oxyethyl)piperazine::US20260008775, Compound 82 7-dehydrocholesterol reductase Homo sapiens 87.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229658 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229658&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372609 336949143 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149331 COCCN1CCN([C@H]2CC[C@@H](c3nc(-c4ccc(C(F)(F)F)nc4)nn3C(C)C)C2)CC1 InChI=1S/C23H33F3N6O/c1-16(2)32-22(28-21(29-32)18-5-7-20(27-15-18)23(24,25)26)17-4-6-19(14-17)31-10-8-30(9-11-31)12-13-33-3/h5,7,15-17,19H,4,6,8-14H2,1-3H3 SRMCQGRFCXLBGZ-UHFFFAOYSA-N 229659 1-((1S,3R)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl) cyclopentyl)-4-(2-methoxy- ethyl)piperazine::US20260008775, Compound 83 7-dehydrocholesterol reductase Homo sapiens 10.9 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229659 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229659&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372610 336949144 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149332 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@@H](N3CCN(C4CCC4)CC3)C[C@@H]21 InChI=1S/C26H34F3N5/c1-16(2)34-23(15-22(31-34)21-7-4-8-24(30-21)26(27,28)29)25-19-13-18(14-20(19)25)33-11-9-32(10-12-33)17-5-3-6-17/h4,7-8,15-20,25H,3,5-6,9-14H2,1-2H3 OUJADMFCDVHQAQ-UHFFFAOYSA-N 229660 1-cyclobutyl-4-((1R,3s,5S, 6r)-6-(1-isopropyl-3-(6-(tri- fluoromethyl)pyridin-2-yl)- 1H-pyrazol-5-yl)bicyclo [3.1.0]hexan-3-ylpiperazine::US20260008775, Compound 84 7-dehydrocholesterol reductase Homo sapiens 27.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229660 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229660&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372611 336949145 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149333 CC(C)n1nc(-c2cccc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@H](N3CCN(C4CCC4)CC3)C[C@@H]21 InChI=1S/C26H34F3N5/c1-16(2)34-23(15-22(31-34)21-7-4-8-24(30-21)26(27,28)29)25-19-13-18(14-20(19)25)33-11-9-32(10-12-33)17-5-3-6-17/h4,7-8,15-20,25H,3,5-6,9-14H2,1-2H3 OUJADMFCDVHQAQ-UHFFFAOYSA-N 229661 1-cyclobutyl-4-((1R,3r,5S, 6r)-6-(1-isopropyl-3-(6-(tri- fluoromethyl)pyridin-2-yl)- 1H-pyrazol-5-yl)bicyclo [3.1.0]hexan-3-yl)piperazine::US20260008775, Compound 85 7-dehydrocholesterol reductase Homo sapiens 472 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229661 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229661&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372612 336949146 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149334 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)cc1[C@@H]1CC[C@@H](N2CCN(CCO)CC2)C1 InChI=1S/C23H32F3N5O/c1-16(2)31-21(14-20(28-31)18-4-6-22(27-15-18)23(24,25)26)17-3-5-19(13-17)30-9-7-29(8-10-30)11-12-32/h4,6,14-17,19,32H,3,5,7-13H2,1-2H3 KNZRGZKUSFXJSS-UHFFFAOYSA-N 229662 2-(4-((1R,3R)-3-(1-isoprop- yl-3-(6-(trifluoromethyl)pyr- idin-3-yl)-1H-pyrazol-5-yl)- cyclopentyl)piperazin-1-yl)- ethanol::US20260008775, Compound 86* 7-dehydrocholesterol reductase Homo sapiens 31.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229662 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229662&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372730 336949147 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149335 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)cc1[C@@H]1CC[C@H](N2CCN(CCO)CC2)C1 InChI=1S/C23H32F3N5O/c1-16(2)31-21(14-20(28-31)18-4-6-22(27-15-18)23(24,25)26)17-3-5-19(13-17)30-9-7-29(8-10-30)11-12-32/h4,6,14-17,19,32H,3,5,7-13H2,1-2H3 KNZRGZKUSFXJSS-UHFFFAOYSA-N 229663 2-(4-((1S,3R)-3-(1-isoprop- yl-3-(6-(trifluoromethyl)pyr- idin-3-yl)-1H-pyrazol-5-yl) cyclopentyl)piperazin-1-yl)- ethanol::US20260008775, Compound 87* 7-dehydrocholesterol reductase Homo sapiens 26.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229663 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229663&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372731 336949148 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149336 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)cc1[C@H]1CC[C@H](N2CCN(CCO)CC2)C1 InChI=1S/C23H32F3N5O/c1-16(2)31-21(14-20(28-31)18-4-6-22(27-15-18)23(24,25)26)17-3-5-19(13-17)30-9-7-29(8-10-30)11-12-32/h4,6,14-17,19,32H,3,5,7-13H2,1-2H3 KNZRGZKUSFXJSS-UHFFFAOYSA-N 229664 2-(4-((1S,3S)-3-(1-isoprop- yl-3-(6-(trifluoromethyl)pyr- idin-3-yl)-1H-pyrazol-5-yl)- cyclopentyl)piperazin-1-yl)- ethanol::US20260008775, Compound 88* 7-dehydrocholesterol reductase Homo sapiens 88.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229664 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229664&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372732 336949149 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149337 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)cc1[C@H]1CC[C@@H](N2CCN(CCO)CC2)C1 InChI=1S/C23H32F3N5O/c1-16(2)31-21(14-20(28-31)18-4-6-22(27-15-18)23(24,25)26)17-3-5-19(13-17)30-9-7-29(8-10-30)11-12-32/h4,6,14-17,19,32H,3,5,7-13H2,1-2H3 KNZRGZKUSFXJSS-UHFFFAOYSA-N 229665 2-(4-((1R,3S)-3-(1-isoprop- yl-3-(6-(trifluoromethyl)pyr- idin-3-yl)-1H-pyrazol-5-yl) cyclopentyl)piperazin-1-yl)- ethanol::US20260008775, Compound 89* 7-dehydrocholesterol reductase Homo sapiens 42.4 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229665 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229665&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372733 336949150 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149338 COCCN1CCN([C@@H]2CC[C@@H](c3cc(-c4ccc(C(F)(F)F)nc4)nn3C(C)C)C2)CC1 InChI=1S/C24H34F3N5O/c1-17(2)32-22(15-21(29-32)19-5-7-23(28-16-19)24(25,26)27)18-4-6-20(14-18)31-10-8-30(9-11-31)12-13-33-3/h5,7,15-18,20H,4,6,8-14H2,1-3H3 ATABEGRMZKMBTJ-UHFFFAOYSA-N 229666 1-((1R,3R)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)-4-(2-methoxyethyl)- piperazine::US20260008775, Compound 90* 7-dehydrocholesterol reductase Homo sapiens 11.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229666 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229666&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372734 336949151 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149339 COCCN1CCN([C@H]2CC[C@@H](c3cc(-c4ccc(C(F)(F)F)nc4)nn3C(C)C)C2)CC1 InChI=1S/C24H34F3N5O/c1-17(2)32-22(15-21(29-32)19-5-7-23(28-16-19)24(25,26)27)18-4-6-20(14-18)31-10-8-30(9-11-31)12-13-33-3/h5,7,15-18,20H,4,6,8-14H2,1-3H3 ATABEGRMZKMBTJ-UHFFFAOYSA-N 229667 1-((1S,3R)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)-4-(2-methoxyethyl) piperazine::US20260008775, Compound 91* 7-dehydrocholesterol reductase Homo sapiens 12.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229667 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229667&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372735 336949152 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149340 COCCN1CCN([C@H]2CC[C@H](c3cc(-c4ccc(C(F)(F)F)nc4)nn3C(C)C)C2)CC1 InChI=1S/C24H34F3N5O/c1-17(2)32-22(15-21(29-32)19-5-7-23(28-16-19)24(25,26)27)18-4-6-20(14-18)31-10-8-30(9-11-31)12-13-33-3/h5,7,15-18,20H,4,6,8-14H2,1-3H3 ATABEGRMZKMBTJ-UHFFFAOYSA-N 229668 1-((1S,3S)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)-4-(2-methoxyethyl)- piperazine::US20260008775, Compound 92* 7-dehydrocholesterol reductase Homo sapiens 77.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229668 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229668&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372856 336949153 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149341 COCCN1CCN([C@@H]2CC[C@H](c3cc(-c4ccc(C(F)(F)F)nc4)nn3C(C)C)C2)CC1 InChI=1S/C24H34F3N5O/c1-17(2)32-22(15-21(29-32)19-5-7-23(28-16-19)24(25,26)27)18-4-6-20(14-18)31-10-8-30(9-11-31)12-13-33-3/h5,7,15-18,20H,4,6,8-14H2,1-3H3 ATABEGRMZKMBTJ-UHFFFAOYSA-N 229669 1-((1R,3S)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-pyrazol-5-yl)cyclo- pentyl)-4-(2-methoxyethyl)- piperazine::US20260008775, Compound 93* 7-dehydrocholesterol reductase Homo sapiens 19.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229669 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229669&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372857 336949154 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149342 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C19H25F3N6O/c1-12(2)28-17(13-3-4-15(9-13)27-5-7-29-8-6-27)25-16(26-28)14-10-23-18(24-11-14)19(20,21)22/h10-13,15H,3-9H2,1-2H3 VAIOSYJXHBQVQN-UHFFFAOYSA-N 229670 4-((1S,3S)-3-(1-isopropyl-3- (2-(trifluoromethyl)pyrim- idin-5-yl)-1H-1,2,4-triazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 94 7-dehydrocholesterol reductase Homo sapiens 243 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229670 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229670&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372858 336949155 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149343 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C19H25F3N6O/c1-12(2)28-17(13-3-4-15(9-13)27-5-7-29-8-6-27)25-16(26-28)14-10-23-18(24-11-14)19(20,21)22/h10-13,15H,3-9H2,1-2H3 VAIOSYJXHBQVQN-UHFFFAOYSA-N 229671 4-((1R,3S)-3-(1-isopropyl-3- (2-(trifluoromethyl)pyrim- idin-5-yl)-1H-1,2,4-triazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 95 7-dehydrocholesterol reductase Homo sapiens 33.3 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229671 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229671&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372859 336949156 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149344 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(8-18(28-30)14-9-26-21(27-10-14)22(23,24)25)20-16-6-15(7-17(16)20)29-4-5-31-11-13(29)3/h8-10,12-13,15-17,20H,4-7,11H2,1-3H3 UMDBQCCPYNMFJG-UHFFFAOYSA-N 229672 (R)-4-((1R,3s,5S,6R)-6-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-5-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 96 7-dehydrocholesterol reductase Homo sapiens 631 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229672 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229672&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372860 336949157 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149345 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)cc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(8-18(28-30)14-9-26-21(27-10-14)22(23,24)25)20-16-6-15(7-17(16)20)29-4-5-31-11-13(29)3/h8-10,12-13,15-17,20H,4-7,11H2,1-3H3 UMDBQCCPYNMFJG-UHFFFAOYSA-N 229673 (R)-4-((1R,3r,5S,6R)-6-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-5-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 97 7-dehydrocholesterol reductase Homo sapiens 15.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229673 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229673&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372861 336949158 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149346 CC(C)n1nc(-c2ccnc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOCC3)C[C@@H]21 InChI=1S/C21H26F3N5O/c1-12(2)29-18(11-17(27-29)16-3-4-25-20(26-16)21(22,23)24)19-14-9-13(10-15(14)19)28-5-7-30-8-6-28/h3-4,11-15,19H,5-10H2,1-2H3 WJPNDDQYXOROTF-UHFFFAOYSA-N 229675 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(2-(trifluorometh- yl)pyrimidin-4-yl)-1H-pyr- azol-5-yl)bicyclo[3.1.0] hexan-3-yl)morpholine::US20260008775, Compound 98 7-dehydrocholesterol reductase Homo sapiens 11.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229675 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229675&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373395 336949160 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149347 CC(C)n1nc(-c2ccnc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@H](N3CCOCC3)C[C@@H]21 InChI=1S/C21H26F3N5O/c1-12(2)29-18(11-17(27-29)16-3-4-25-20(26-16)21(22,23)24)19-14-9-13(10-15(14)19)28-5-7-30-8-6-28/h3-4,11-15,19H,5-10H2,1-2H3 WJPNDDQYXOROTF-UHFFFAOYSA-N 229676 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(2-(trifluorometh- yl)pyrimidin-4-yl)-1H-pyr- azol-5-yl)bicyclo[3.1.0] hexan-3-yl)morpholine::US20260008775, Compound 99 7-dehydrocholesterol reductase Homo sapiens 87.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229676 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229676&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373396 336949161 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149348 CC(C)n1nc(-c2ccnc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(10-18(28-30)17-4-5-26-21(27-17)22(23,24)25)20-15-8-14(9-16(15)20)29-6-7-31-11-13(29)3/h4-5,10,12-16,20H,6-9,11H2,1-3H3 LFNGOWLCBICNON-UHFFFAOYSA-N 229677 (S)-4-((1R,3s,5S,6S)-6-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-4-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 100 7-dehydrocholesterol reductase Homo sapiens 11.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229677 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229677&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373397 336949162 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149349 CC(C)n1nc(-c2ccnc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(10-18(28-30)17-4-5-26-21(27-17)22(23,24)25)20-15-8-14(9-16(15)20)29-6-7-31-11-13(29)3/h4-5,10,12-16,20H,6-9,11H2,1-3H3 LFNGOWLCBICNON-UHFFFAOYSA-N 229678 (S)-4-((1R,3r,5S,6S)-6-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-4-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 101 7-dehydrocholesterol reductase Homo sapiens 7.22 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229678 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229678&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373398 336949163 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149350 CC(C)n1nc(-c2ccnc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(10-18(28-30)17-4-5-26-21(27-17)22(23,24)25)20-15-8-14(9-16(15)20)29-6-7-31-11-13(29)3/h4-5,10,12-16,20H,6-9,11H2,1-3H3 LFNGOWLCBICNON-UHFFFAOYSA-N 229679 (R)-4-((1R,3s,5S,6S)-6-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-4-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 102 7-dehydrocholesterol reductase Homo sapiens 73.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229679 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229679&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373533 336949164 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149351 CC(C)n1nc(-c2ccnc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(10-18(28-30)17-4-5-26-21(27-17)22(23,24)25)20-15-8-14(9-16(15)20)29-6-7-31-11-13(29)3/h4-5,10,12-16,20H,6-9,11H2,1-3H3 LFNGOWLCBICNON-UHFFFAOYSA-N 229680 (R)-4-((1R,3r,5S,6S)-6-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-4-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 103 7-dehydrocholesterol reductase Homo sapiens 36.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229680 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229680&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373534 336949165 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149352 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C20H26F3N5O/c1-13(2)28-19(14-3-5-16(11-14)27-7-9-29-10-8-27)25-18(26-28)15-4-6-17(24-12-15)20(21,22)23/h4,6,12-14,16H,3,5,7-11H2,1-2H3 YUGAHDIRTUGMOQ-UHFFFAOYSA-N 229681 4-((1R,3R)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 104 7-dehydrocholesterol reductase Homo sapiens 19.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229681 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229681&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373535 336949166 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149353 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C20H26F3N5O/c1-13(2)28-19(14-3-5-16(11-14)27-7-9-29-10-8-27)25-18(26-28)15-4-6-17(24-12-15)20(21,22)23/h4,6,12-14,16H,3,5,7-11H2,1-2H3 YUGAHDIRTUGMOQ-UHFFFAOYSA-N 229682 4-((1S,3R)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin-3- yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 105 7-dehydrocholesterol reductase Homo sapiens 8.89 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229682 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229682&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373536 336949167 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149354 CC(C)n1nc(-c2cc(C(F)(F)F)ncn2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(8-18(28-30)17-9-20(22(23,24)25)27-11-26-17)21-15-6-14(7-16(15)21)29-4-5-31-10-13(29)3/h8-9,11-16,21H,4-7,10H2,1-3H3 IPCGPOZOPIYPAO-UHFFFAOYSA-N 229683 (R)-4-((1R,3s,5S,6R)-6-(1- isopropyl-3-(6-(trifluoro- methyl)pyrimidin-4-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 202 7-dehydrocholesterol reductase Homo sapiens 17.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229683 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229683&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373537 336949168 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149355 CC(C)n1nc(-c2cc(C(F)(F)F)ncn2)cc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(8-18(28-30)17-9-20(22(23,24)25)27-11-26-17)21-15-6-14(7-16(15)21)29-4-5-31-10-13(29)3/h8-9,11-16,21H,4-7,10H2,1-3H3 IPCGPOZOPIYPAO-UHFFFAOYSA-N 229684 (R)-4-((1R,3r,5S,6R)-6-(1- isopropyl-3-(6-(trifluoro- methyl)pyrimidin-4-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 106 7-dehydrocholesterol reductase Homo sapiens 15.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229684 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229684&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373538 336949169 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149356 CC(C)n1nc(-c2cncc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOCC3)C[C@@H]21 InChI=1S/C21H26F3N5O/c1-12(2)29-18(9-16(27-29)17-10-25-11-19(26-17)21(22,23)24)20-14-7-13(8-15(14)20)28-3-5-30-6-4-28/h9-15,20H,3-8H2,1-2H3 ZABMZPZZDHQJQU-UHFFFAOYSA-N 229686 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(6-(trifluorometh- yl)pyrazin-2-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)morpholine::US20260008775, Compound 107 7-dehydrocholesterol reductase Homo sapiens 11.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229686 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229686&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371553 336949171 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149357 CC(C)n1nc(-c2cncc(C(F)(F)F)n2)cc1[C@H]1[C@@H]2C[C@H](N3CCOCC3)C[C@@H]21 InChI=1S/C21H26F3N5O/c1-12(2)29-18(9-16(27-29)17-10-25-11-19(26-17)21(22,23)24)20-14-7-13(8-15(14)20)28-3-5-30-6-4-28/h9-15,20H,3-8H2,1-2H3 ZABMZPZZDHQJQU-UHFFFAOYSA-N 229687 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(6-(trifluorometh- yl)pyrazin-2-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)morpholine::US20260008775, Compound 108 7-dehydrocholesterol reductase Homo sapiens 87.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229687 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229687&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371554 336949172 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149358 CC[C@@H]1CN([C@@H]2CC[C@H](c3nc(-c4cnc(C(F)(F)F)nc4)nn3C(C)C)C2)CCO1 InChI=1S/C21H29F3N6O/c1-4-17-12-29(7-8-31-17)16-6-5-14(9-16)19-27-18(28-30(19)13(2)3)15-10-25-20(26-11-15)21(22,23)24/h10-11,13-14,16-17H,4-9,12H2,1-3H3 ZKOJFYOINQSWFL-UHFFFAOYSA-N 229688 (R)-2-ethyl-4-((1R,3S)-3-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-5-yl)-1H- 1,2,4-triazol-5-yl)cyclopent- yl)morpholine::US20260008775, Compound 109* 7-dehydrocholesterol reductase Homo sapiens 164 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229688 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229688&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371556 336949173 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149359 CC[C@H]1CN([C@@H]2CC[C@H](c3nc(-c4cnc(C(F)(F)F)nc4)nn3C(C)C)C2)CCO1 InChI=1S/C21H29F3N6O/c1-4-17-12-29(7-8-31-17)16-6-5-14(9-16)19-27-18(28-30(19)13(2)3)15-10-25-20(26-11-15)21(22,23)24/h10-11,13-14,16-17H,4-9,12H2,1-3H3 ZKOJFYOINQSWFL-UHFFFAOYSA-N 229689 (S)-2-ethyl-4-((1R,3S)-3-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-5-yl)-1H- 1,2,4-triazol-5-yl)cyclopent- yl)morpholine::US20260008775, Compound 110* 7-dehydrocholesterol reductase Homo sapiens 14.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229689 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229689&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371555 336949174 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149360 CC(C)n1nc(-c2ccc(C(F)(F)F)c(F)c2)nc1[C@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C21H26F4N4O/c1-13(2)29-20(15-3-5-16(11-15)28-7-9-30-10-8-28)26-19(27-29)14-4-6-17(18(22)12-14)21(23,24)25/h4,6,12-13,15-16H,3,5,7-11H2,1-2H3 CRVJMMSFESLJNF-UHFFFAOYSA-N 229690 4-((1R,3S)-3-(3-(3-fluoro-4- (trifluoromethyl)phenyl)-1- isopropyl-1H-1,2,4-triazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 111* 7-dehydrocholesterol reductase Homo sapiens 45.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229690 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229690&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371557 336949175 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149361 CC(C)n1nc(-c2ccc(C(F)(F)F)c(F)c2)nc1[C@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C21H26F4N4O/c1-13(2)29-20(15-3-5-16(11-15)28-7-9-30-10-8-28)26-19(27-29)14-4-6-17(18(22)12-14)21(23,24)25/h4,6,12-13,15-16H,3,5,7-11H2,1-2H3 CRVJMMSFESLJNF-UHFFFAOYSA-N 229691 4-((1S,3S)-3-(3-(3-fluoro-4- (trifluoromethyl)phenyl)-1- isopropyl-1H-1,2,4-triazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 112* 7-dehydrocholesterol reductase Homo sapiens 90.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229691 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229691&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371558 336949176 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149362 CC(C)n1nc(-c2ccc(C(F)(F)F)c(F)c2)nc1[C@@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C21H26F4N4O/c1-13(2)29-20(15-3-5-16(11-15)28-7-9-30-10-8-28)26-19(27-29)14-4-6-17(18(22)12-14)21(23,24)25/h4,6,12-13,15-16H,3,5,7-11H2,1-2H3 CRVJMMSFESLJNF-UHFFFAOYSA-N 229693 4-((1S,3R)-3-(3-(3-fluoro-4- (trifluoromethyl)phenyl)-1- isopropyl-1H-1,2,4-triazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 113* 7-dehydrocholesterol reductase Homo sapiens 9.73 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229693 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229693&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371690 336949178 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149363 CC(C)n1nc(-c2ccc(C(F)(F)F)c(F)c2)nc1[C@@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C21H26F4N4O/c1-13(2)29-20(15-3-5-16(11-15)28-7-9-30-10-8-28)26-19(27-29)14-4-6-17(18(22)12-14)21(23,24)25/h4,6,12-13,15-16H,3,5,7-11H2,1-2H3 CRVJMMSFESLJNF-UHFFFAOYSA-N 229695 4-((1R,3R)-3-(3-(3-fluoro-4- (trifluoromethyl)phenyl)-1- isopropyl-1H-1,2,4-triazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 114* 7-dehydrocholesterol reductase Homo sapiens 14.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229695 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229695&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371692 336949180 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149364 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C20H26F3N5O/c1-13(2)28-19(14-3-4-17(10-14)27-5-7-29-8-6-27)25-18(26-28)15-9-16(12-24-11-15)20(21,22)23/h9,11-14,17H,3-8,10H2,1-2H3 FXKAOUSZFLXMAJ-UHFFFAOYSA-N 229696 4-((1R,3R)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 115* 7-dehydrocholesterol reductase Homo sapiens 35.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229696 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229696&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371693 336949181 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149365 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C20H26F3N5O/c1-13(2)28-19(14-3-4-17(10-14)27-5-7-29-8-6-27)25-18(26-28)15-9-16(12-24-11-15)20(21,22)23/h9,11-14,17H,3-8,10H2,1-2H3 FXKAOUSZFLXMAJ-UHFFFAOYSA-N 229697 4-((1S,3S)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin-3- yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 116* 7-dehydrocholesterol reductase Homo sapiens 169 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229697 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229697&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371694 336949182 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149366 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C20H26F3N5O/c1-13(2)28-19(14-3-4-17(10-14)27-5-7-29-8-6-27)25-18(26-28)15-9-16(12-24-11-15)20(21,22)23/h9,11-14,17H,3-8,10H2,1-2H3 FXKAOUSZFLXMAJ-UHFFFAOYSA-N 229698 4-((1S,3R)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 117* 7-dehydrocholesterol reductase Homo sapiens 34.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229698 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229698&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371695 336949183 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149367 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C20H26F3N5O/c1-13(2)28-19(14-3-4-17(10-14)27-5-7-29-8-6-27)25-18(26-28)15-9-16(12-24-11-15)20(21,22)23/h9,11-14,17H,3-8,10H2,1-2H3 FXKAOUSZFLXMAJ-UHFFFAOYSA-N 229699 4-((1R,3S)-3-(1-isopropyl-3- (5-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 118* 7-dehydrocholesterol reductase Homo sapiens 32.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229699 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229699&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371819 336949184 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149368 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-21(27-20(28-30)14-6-15(10-26-9-14)22(23,24)25)19-17-7-16(8-18(17)19)29-4-5-31-11-13(29)3/h6,9-10,12-13,16-19H,4-5,7-8,11H2,1-3H3 NXIMDJKNHHBKIC-UHFFFAOYSA-N 229700 (R)-4-((1R,3s,5S,6R)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- 1,2,4-triazol-5-l)bicyclo [3.1.0]hexan-3-yl)-3-methyl- morpholine::US20260008775, Compound 119 7-dehydrocholesterol reductase Homo sapiens 584 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229700 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229700&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371820 336949185 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149369 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-21(27-20(28-30)14-6-15(10-26-9-14)22(23,24)25)19-17-7-16(8-18(17)19)29-4-5-31-11-13(29)3/h6,9-10,12-13,16-19H,4-5,7-8,11H2,1-3H3 NXIMDJKNHHBKIC-UHFFFAOYSA-N 229701 (R)-4-((1R,3r,5S,6R)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- 1,2,4-triazol-5-l)bicyclo [3.1.0]hexan-3-yl)-3-methyl- morpholine::US20260008775, Compound 120 7-dehydrocholesterol reductase Homo sapiens 16.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229701 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229701&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371821 336949186 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149370 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-21(27-20(28-30)14-6-15(10-26-9-14)22(23,24)25)19-17-7-16(8-18(17)19)29-4-5-31-11-13(29)3/h6,9-10,12-13,16-19H,4-5,7-8,11H2,1-3H3 NXIMDJKNHHBKIC-UHFFFAOYSA-N 229702 (S)-4-((1R,3s,5S,6R)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- 1,2,4-triazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-3-methyl- morpholine::US20260008775, Compound 121 7-dehydrocholesterol reductase Homo sapiens 564 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229702 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229702&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371822 336949187 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149371 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-21(27-20(28-30)14-6-15(10-26-9-14)22(23,24)25)19-17-7-16(8-18(17)19)29-4-5-31-11-13(29)3/h6,9-10,12-13,16-19H,4-5,7-8,11H2,1-3H3 NXIMDJKNHHBKIC-UHFFFAOYSA-N 229703 (S)-4-((1R,3r,5S,6R)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- 1,2,4-triazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-3-methyl- morpholine::US20260008775, Compound 122 7-dehydrocholesterol reductase Homo sapiens 26.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229703 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229703&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371823 336949188 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149372 CC[C@H]1CN([C@@H]2CC[C@H](c3nc(-c4cncc(F)c4)nn3C(C)C)C2)CCO1 InChI=1S/C21H30FN5O/c1-4-19-13-26(7-8-28-19)18-6-5-15(10-18)21-24-20(25-27(21)14(2)3)16-9-17(22)12-23-11-16/h9,11-12,14-15,18-19H,4-8,10,13H2,1-3H3 RBRMVMFCALCXOF-UHFFFAOYSA-N 229705 (S)-2-ethyl-4-((1R,3S)-3-(3- (5-fluoropyridin-3-yl)-1- isopropyl-1H-1,2,4-triazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 123 7-dehydrocholesterol reductase Homo sapiens 40.4 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229705 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229705&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371824 336949189 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149373 CC[C@@H]1CN([C@@H]2CC[C@H](c3nc(-c4cncc(F)c4)nn3C(C)C)C2)CCO1 InChI=1S/C21H30FN5O/c1-4-19-13-26(7-8-28-19)18-6-5-15(10-18)21-24-20(25-27(21)14(2)3)16-9-17(22)12-23-11-16/h9,11-12,14-15,18-19H,4-8,10,13H2,1-3H3 RBRMVMFCALCXOF-UHFFFAOYSA-N 229706 (R)-2-ethyl-4-((1R,3S)-3-(3- (5-fluoropyridin-3-yl)-1- isopropyl-1H-1,2,4-triazol- 5-yl)cyclopentyl)morpholine::US20260008775, Compound 124 7-dehydrocholesterol reductase Homo sapiens 2400 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229706 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229706&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371944 336949190 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149374 CC(C)n1nc(-c2cncc(Cl)c2)nc1[C@H]1CC[C@H](N2CCOC[C@@H]2C)C1 InChI=1S/C20H28ClN5O/c1-13(2)26-20(23-19(24-26)16-8-17(21)11-22-10-16)15-4-5-18(9-15)25-6-7-27-12-14(25)3/h8,10-11,13-15,18H,4-7,9,12H2,1-3H3 FEWRCYDFJOLITD-UHFFFAOYSA-N 229707 (S)-4-((1S,3S)-3-(3-(5- chloropyridin-3-yl)-1-iso- propyl-1H-1,2,4-triazol-5- yl)cyclopentyl)-3-methyl- morpholine::US20260008775, Compound 125 7-dehydrocholesterol reductase Homo sapiens 245 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229707 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229707&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371945 336949191 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149375 CC(C)n1nc(-c2cncc(Cl)c2)nc1[C@H]1CC[C@@H](N2CCOC[C@@H]2C)C1 InChI=1S/C20H28ClN5O/c1-13(2)26-20(23-19(24-26)16-8-17(21)11-22-10-16)15-4-5-18(9-15)25-6-7-27-12-14(25)3/h8,10-11,13-15,18H,4-7,9,12H2,1-3H3 FEWRCYDFJOLITD-UHFFFAOYSA-N 229708 (S)-4-((1R,3S)-3-(3-(5- chloropyridin-3-yl)-1-iso- propyl-1H-1,2,4-triazol-5- yl)cyclopentyl)-3-methyl- morpholine::US20260008775, Compound 126 7-dehydrocholesterol reductase Homo sapiens 30.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229708 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229708&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371946 336949192 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149376 CC[C@@H]1CN([C@@H]2CC[C@H](c3nc(-c4ccc(C(F)(F)F)nc4)nn3C(C)C)C2)CCO1 InChI=1S/C22H30F3N5O/c1-4-18-13-29(9-10-31-18)17-7-5-15(11-17)21-27-20(28-30(21)14(2)3)16-6-8-19(26-12-16)22(23,24)25/h6,8,12,14-15,17-18H,4-5,7,9-11,13H2,1-3H3 XHCIRYNENBBBTO-UHFFFAOYSA-N 229709 (R)-2-ethyl-4-((1R,3S)-3-(1- isopropyl-3-(6-(trifluoro- methyl)pyridin-3-yl)-1H- 1,2,4-triazol-5-yl)cyclopent- yl)morpholine::US20260008775, Compound 127 7-dehydrocholesterol reductase Homo sapiens 57.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229709 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229709&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371947 336949193 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149377 CC[C@H]1CN([C@@H]2CC[C@H](c3nc(-c4ccc(C(F)(F)F)nc4)nn3C(C)C)C2)CCO1 InChI=1S/C22H30F3N5O/c1-4-18-13-29(9-10-31-18)17-7-5-15(11-17)21-27-20(28-30(21)14(2)3)16-6-8-19(26-12-16)22(23,24)25/h6,8,12,14-15,17-18H,4-5,7,9-11,13H2,1-3H3 XHCIRYNENBBBTO-UHFFFAOYSA-N 229710 (S)-2-ethyl-4-((1R,3S)-3-(1- isopropyl-3-(6-(trifluoro- methyl)pyridin-3-yl)-1H- 1,2,4-triazol-5-yl)cyclopent- yl)morpholine::US20260008775, Compound 128 7-dehydrocholesterol reductase Homo sapiens 118 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229710&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371948 336949194 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149378 CC[C@@H]1CN([C@@H]2CC[C@H](c3nc(-c4cncc(Cl)c4)nn3C(C)C)C2)CCO1 InChI=1S/C21H30ClN5O/c1-4-19-13-26(7-8-28-19)18-6-5-15(10-18)21-24-20(25-27(21)14(2)3)16-9-17(22)12-23-11-16/h9,11-12,14-15,18-19H,4-8,10,13H2,1-3H3 SEJAOTVZMAHUFU-UHFFFAOYSA-N 229711 (R)-4-((1R,3S)-3-(3-(5- chloropyridin-3-yl)-1-iso- propyl-1H-1,2,4-triazol-5- yl)cyclopentyl)-2-ethylmor- pholine::US20260008775, Compound 129 7-dehydrocholesterol reductase Homo sapiens 23.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229711 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229711&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53371949 336949195 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149379 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)cc1[C@H]1CC[C@H](N2CCO[C@@H](CF)C2)C1 InChI=1S/C21H27F4N5O/c1-13(2)30-19(8-18(28-30)15-10-26-20(27-11-15)21(23,24)25)14-3-4-16(7-14)29-5-6-31-17(9-22)12-29/h8,10-11,13-14,16-17H,3-7,9,12H2,1-2H3 CNNOEAYPIHRPDG-UHFFFAOYSA-N 229712 (R)-2-(fluoromethyl)-4- ((1S,3S)-3-(1-isopropyl-3- (2-(trifluoromethyl)pyr- imidin-5-yl)-1H-pyrazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 130* 7-dehydrocholesterol reductase Homo sapiens 392 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229712&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312592 336949196 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149380 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)cc1[C@H]1CC[C@@H](N2CCO[C@@H](CF)C2)C1 InChI=1S/C21H27F4N5O/c1-13(2)30-19(8-18(28-30)15-10-26-20(27-11-15)21(23,24)25)14-3-4-16(7-14)29-5-6-31-17(9-22)12-29/h8,10-11,13-14,16-17H,3-7,9,12H2,1-2H3 CNNOEAYPIHRPDG-UHFFFAOYSA-N 229713 (R)-2-(fluoromethyl)-4- ((1R,3S)-3-(1-isopropyl-3- (2-(trifluoromethyl)pyr- imidin-5-yl)-1H-pyrazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 131* 7-dehydrocholesterol reductase Homo sapiens 106 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229713&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372077 336949197 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149381 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)cc1[C@H]1CC[C@H](N2CCO[C@H](CF)C2)C1 InChI=1S/C21H27F4N5O/c1-13(2)30-19(8-18(28-30)15-10-26-20(27-11-15)21(23,24)25)14-3-4-16(7-14)29-5-6-31-17(9-22)12-29/h8,10-11,13-14,16-17H,3-7,9,12H2,1-2H3 CNNOEAYPIHRPDG-UHFFFAOYSA-N 229714 (S)-2-(fluoromethyl)-4- ((1S,3S)-3-(1-isopropyl-3- (2-(trifluoromethyl)pyr- imidin-5-yl)-1H-pyrazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 132* 7-dehydrocholesterol reductase Homo sapiens 88.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229714 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229714&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372078 336949198 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149382 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)cc1[C@H]1CC[C@@H](N2CCO[C@H](CF)C2)C1 InChI=1S/C21H27F4N5O/c1-13(2)30-19(8-18(28-30)15-10-26-20(27-11-15)21(23,24)25)14-3-4-16(7-14)29-5-6-31-17(9-22)12-29/h8,10-11,13-14,16-17H,3-7,9,12H2,1-2H3 CNNOEAYPIHRPDG-UHFFFAOYSA-N 229715 (S)-2-(fluoromethyl)-4- ((1R,3S)-3-(1-isopropyl-3- (2-(trifluoromethyl)pyrim- idin-5-yl)-1H-pyrazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 133* 7-dehydrocholesterol reductase Homo sapiens 17.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229715 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229715&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372079 336949199 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149383 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@H]1CC[C@@H](N2CCO[C@H](C)C2)C1 InChI=1S/C20H27F3N6O/c1-12(2)29-18(14-4-5-16(8-14)28-6-7-30-13(3)11-28)26-17(27-29)15-9-24-19(25-10-15)20(21,22)23/h9-10,12-14,16H,4-8,11H2,1-3H3 QADYYASKMIODGB-UHFFFAOYSA-N 229716 (R)-4-((1R,3S)-3-(1-iso- propyl-3-(2-(trifluorometh- yl)pyrimidin-5-yl)-1H-1,2,4- triazol-5-yl)cyclopentyl)-2- methylmorpholine::US20260008775, Compound 144 7-dehydrocholesterol reductase Homo sapiens 325 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229716 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229716&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372080 336949200 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149384 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@H]1CC[C@H](N2CCO[C@H](C)C2)C1 InChI=1S/C20H27F3N6O/c1-12(2)29-18(14-4-5-16(8-14)28-6-7-30-13(3)11-28)26-17(27-29)15-9-24-19(25-10-15)20(21,22)23/h9-10,12-14,16H,4-8,11H2,1-3H3 QADYYASKMIODGB-UHFFFAOYSA-N 229717 (R)-4-((1S,3S)-3-(1-iso- propyl-3-(2-(trifluorometh- yl)pyrimidin-5-yl)-1H-1,2,4- triazol-5-yl)cyclopentyl)-2- methylmorpholine::US20260008775, Compound 145 7-dehydrocholesterol reductase Homo sapiens 299 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229717&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372081 336949201 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149385 CC[C@@H]1CN([C@@H]2CC[C@H](c3nc(-c4cnc(C(F)(F)F)c(F)c4)nn3C(C)C)C2)CCO1 InChI=1S/C22H29F4N5O/c1-4-17-12-30(7-8-32-17)16-6-5-14(9-16)21-28-20(29-31(21)13(2)3)15-10-18(23)19(27-11-15)22(24,25)26/h10-11,13-14,16-17H,4-9,12H2,1-3H3 ZZQGRZFHGBAJSI-UHFFFAOYSA-N 229718 (R)-2-ethyl-4-((1R,3S)-3-(3- (5-fluoro-6-(trifluoromethyl)- pyridin-3-yl)-1-isopropyl-1H- 1,2,4-triazol-5-yl)cyclopent- yl)morpholine::US20260008775, Compound 146 7-dehydrocholesterol reductase Homo sapiens 11.3 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229718 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229718&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53372082 336949202 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149386 CC[C@H]1CN([C@@H]2CC[C@H](c3nc(-c4cnc(C(F)(F)F)c(F)c4)nn3C(C)C)C2)CCO1 InChI=1S/C22H29F4N5O/c1-4-17-12-30(7-8-32-17)16-6-5-14(9-16)21-28-20(29-31(21)13(2)3)15-10-18(23)19(27-11-15)22(24,25)26/h10-11,13-14,16-17H,4-9,12H2,1-3H3 ZZQGRZFHGBAJSI-UHFFFAOYSA-N 229719 (S)-2-ethyl-4-((1R,3S)-3-(3- (5-fluoro-6-(trifluorometh- yl)pyridin-3-yl)-1-isopropyl- 1H-1,2,4-triazol-5-yl)cyclo- pentyl)morpholine::US20260008775, Compound 147 7-dehydrocholesterol reductase Homo sapiens 1740 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229719 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229719&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312616 336949203 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149387 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@@H]1CC[C@H](N2CCO[C@H](C)C2)C1 InChI=1S/C20H27F3N6O/c1-12(2)29-18(14-4-5-16(8-14)28-6-7-30-13(3)11-28)26-17(27-29)15-9-24-19(25-10-15)20(21,22)23/h9-10,12-14,16H,4-8,11H2,1-3H3 QADYYASKMIODGB-UHFFFAOYSA-N 229720 (R)-4-((1S,3R)-3-(1-isoprop- yl-3-(2-(trifluoromethyl)pyr- imidin-5-yl)-1H-1,2,4-tri- azol-5-yl)cyclopentyl)-2- methylmorpholine::US20260008775, Compound 148 7-dehydrocholesterol reductase Homo sapiens 22.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229720&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312720 336949204 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149388 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@@H]1CC[C@@H](N2CCO[C@H](C)C2)C1 InChI=1S/C20H27F3N6O/c1-12(2)29-18(14-4-5-16(8-14)28-6-7-30-13(3)11-28)26-17(27-29)15-9-24-19(25-10-15)20(21,22)23/h9-10,12-14,16H,4-8,11H2,1-3H3 QADYYASKMIODGB-UHFFFAOYSA-N 229721 (R)-4-((1R,3R)-3-(1-isoprop- yl-3-(2-(trifluoromethyl)pyr- imidin-5-yl)-1H-1,2,4-triazol- 5-yl)cyclopentyl)-2-methyl- morpholine::US20260008775, Compound 149 7-dehydrocholesterol reductase Homo sapiens 68.3 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229721&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312750 336949205 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149389 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@@H]1CC[C@H](N2CCO[C@@H](C)C2)C1 InChI=1S/C20H27F3N6O/c1-12(2)29-18(14-4-5-16(8-14)28-6-7-30-13(3)11-28)26-17(27-29)15-9-24-19(25-10-15)20(21,22)23/h9-10,12-14,16H,4-8,11H2,1-3H3 QADYYASKMIODGB-UHFFFAOYSA-N 229722 (S)-4-((1S,3R)-3-(1-isoprop- yl-3-(2-(trifluoromethyl)- pyrimidin-5-yl)-1H-1,2,4- triazol-5-yl)cyclopentyl)-2- methylmorpholine::US20260008775, Compound 150 7-dehydrocholesterol reductase Homo sapiens 3540 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229722&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312612 336949206 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149390 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@@H]1CC[C@@H](N2CCO[C@@H](C)C2)C1 InChI=1S/C20H27F3N6O/c1-12(2)29-18(14-4-5-16(8-14)28-6-7-30-13(3)11-28)26-17(27-29)15-9-24-19(25-10-15)20(21,22)23/h9-10,12-14,16H,4-8,11H2,1-3H3 QADYYASKMIODGB-UHFFFAOYSA-N 229723 (S)-4-((1R,3R)-3-(1-isoprop- yl-3-(2-(trifluoromethyl)pyr- imidin-5-yl)-1H-1,2,4-triazol- 5-yl)cyclopentyl)-2-methyl- morpholine::US20260008775, Compound 151 7-dehydrocholesterol reductase Homo sapiens 505 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229723 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229723&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312685 336949207 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149391 CC[C@@H]1CN([C@H]2CC[C@@H](c3nc(-c4cnc(C(F)(F)F)nc4)nn3C(C)C)C2)CCO1 InChI=1S/C21H29F3N6O/c1-4-17-12-29(7-8-31-17)16-6-5-14(9-16)19-27-18(28-30(19)13(2)3)15-10-25-20(26-11-15)21(22,23)24/h10-11,13-14,16-17H,4-9,12H2,1-3H3 ZKOJFYOINQSWFL-UHFFFAOYSA-N 229724 (R)-2-ethyl-4-((1S,3R)-3-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-5-yl)-1H- 1,2,4-triazol-5-yl)cyclopent- yl)morpholine::US20260008775, Compound 152 7-dehydrocholesterol reductase Homo sapiens 3420 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229724&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312659 336949208 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149392 CC[C@@H]1CN([C@@H]2CC[C@@H](c3nc(-c4cnc(C(F)(F)F)nc4)nn3C(C)C)C2)CCO1 InChI=1S/C21H29F3N6O/c1-4-17-12-29(7-8-31-17)16-6-5-14(9-16)19-27-18(28-30(19)13(2)3)15-10-25-20(26-11-15)21(22,23)24/h10-11,13-14,16-17H,4-9,12H2,1-3H3 ZKOJFYOINQSWFL-UHFFFAOYSA-N 229725 (R)-2-ethyl-4-((1R,3R)-3-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-5-yl)-1H- 1,2,4-triazol-5-yl)cyclopent- yl)morpholine::US20260008775, Compound 153 7-dehydrocholesterol reductase Homo sapiens 58.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229725&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312652 336949209 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149393 CC[C@H]1CN([C@H]2CC[C@@H](c3nc(-c4cnc(C(F)(F)F)nc4)nn3C(C)C)C2)CCO1 InChI=1S/C21H29F3N6O/c1-4-17-12-29(7-8-31-17)16-6-5-14(9-16)19-27-18(28-30(19)13(2)3)15-10-25-20(26-11-15)21(22,23)24/h10-11,13-14,16-17H,4-9,12H2,1-3H3 ZKOJFYOINQSWFL-UHFFFAOYSA-N 229726 (S)-2-ethyl-4-((1S,3R)-3-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-5-yl)-1H- 1,2,4-triazol-5-yl)cyclopent- yl)morpholine::US20260008775, Compound 154 7-dehydrocholesterol reductase Homo sapiens 465 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229726 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229726&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312625 336949210 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149394 CC[C@H]1CN([C@@H]2CC[C@@H](c3nc(-c4cnc(C(F)(F)F)nc4)nn3C(C)C)C2)CCO1 InChI=1S/C21H29F3N6O/c1-4-17-12-29(7-8-31-17)16-6-5-14(9-16)19-27-18(28-30(19)13(2)3)15-10-25-20(26-11-15)21(22,23)24/h10-11,13-14,16-17H,4-9,12H2,1-3H3 ZKOJFYOINQSWFL-UHFFFAOYSA-N 229727 (S)-2-ethyl-4-((1R,3R)-3-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-5-yl)-1H- 1,2,4-triazol-5-yl)cyclopent- yl)morpholine::US20260008775, Compound 155 7-dehydrocholesterol reductase Homo sapiens 465 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229727&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312776 336949211 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149395 CC[C@@H]1CN([C@@H]2CC[C@H](c3nc(-c4ccc(C(F)(F)F)nc4)nn3C(C)C)C2)CCO1 InChI=1S/C22H30F3N5O/c1-4-18-13-29(9-10-31-18)17-7-5-15(11-17)21-27-20(28-30(21)14(2)3)16-6-8-19(26-12-16)22(23,24)25/h6,8,12,14-15,17-18H,4-5,7,9-11,13H2,1-3H3 XHCIRYNENBBBTO-UHFFFAOYSA-N 229729 (R)-4-((1R,3S)-3-(3-(6- (difluoromethyl)pyridin-3- yl)-1-isopropyl-1H-1,2,4- triazol-5-yl)cyclopentyl)-2- ethylmorpholine::US20260008775, Compound 156 7-dehydrocholesterol reductase Homo sapiens 43.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229729&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 67355595 336949213 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149396 CC(C)n1nc(-c2cnc(F)c(C(F)(F)F)c2)nc1[C@@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C20H25F4N5O/c1-12(2)29-19(13-3-4-15(9-13)28-5-7-30-8-6-28)26-18(27-29)14-10-16(20(22,23)24)17(21)25-11-14/h10-13,15H,3-9H2,1-2H3 HMCWXFAAHPZGSF-UHFFFAOYSA-N 229730 4-((1S,3R)-3-(3-(6-fluoro-5- (trifluoromethyl)pyridin-3- yl)-1-isopropyl-1H-1,2,4- triazol-5-yl)cyclopentyl)- morpholine::US20260008775, Compound 157* 7-dehydrocholesterol reductase Homo sapiens 51.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229730&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312602 336949214 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149397 CC(C)n1nc(-c2cnc(F)c(C(F)(F)F)c2)nc1[C@H]1CC[C@@H](N2CCOCC2)C1 InChI=1S/C20H25F4N5O/c1-12(2)29-19(13-3-4-15(9-13)28-5-7-30-8-6-28)26-18(27-29)14-10-16(20(22,23)24)17(21)25-11-14/h10-13,15H,3-9H2,1-2H3 HMCWXFAAHPZGSF-UHFFFAOYSA-N 229731 4-((1R,3S)-3-(3-(6-fluoro-5- (trifluoromethyl)pyridin-3- yl)-1-isopropyl-1H-1,2,4- triazol-5-yl)cyclopentyl)mor- pholine::US20260008775, Compound 158* 7-dehydrocholesterol reductase Homo sapiens 33.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229731&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312792 336949215 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149398 CC(C)n1nc(-c2cnc(F)c(C(F)(F)F)c2)nc1[C@H]1CC[C@H](N2CCOCC2)C1 InChI=1S/C20H25F4N5O/c1-12(2)29-19(13-3-4-15(9-13)28-5-7-30-8-6-28)26-18(27-29)14-10-16(20(22,23)24)17(21)25-11-14/h10-13,15H,3-9H2,1-2H3 HMCWXFAAHPZGSF-UHFFFAOYSA-N 229733 4-((1S,3S)-3-(3-(6-fluoro-5- (trifluoromethyl)pyridin-3- yl)-1-isopropyl-1H-1,2,4- triazol-5-yl)cyclopentyl)- morpholine::US20260008775, Compound 159* 7-dehydrocholesterol reductase Homo sapiens 12.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229733&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312753 336949216 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149399 CC(C)n1nc(-c2ccc(C(F)(F)F)c(F)c2)nc1[C@H]1CC[C@@H](N2CCO[C@H](CF)C2)C1 InChI=1S/C22H27F5N4O/c1-13(2)31-21(15-3-5-16(9-15)30-7-8-32-17(11-23)12-30)28-20(29-31)14-4-6-18(19(24)10-14)22(25,26)27/h4,6,10,13,15-17H,3,5,7-9,11-12H2,1-2H3 GKOSHPHZHVEJPZ-UHFFFAOYSA-N 229734 (S)-4-((1R,3S)-3-(3-(3- fluoro-4-(trifluoromethyl)- phenyl)-1-isopropyl-1H- 1,2,4-triazol-5-yl)cyclo- pentyl)-2-(fluoromethyl) morpholine::US20260008775, Compound 160 7-dehydrocholesterol reductase Homo sapiens 32.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229734&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312832 336949217 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149400 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@H]1CC[C@@H](N2CCO[C@H](CF)C2)C1 InChI=1S/C20H26F4N6O/c1-12(2)30-18(13-3-4-15(7-13)29-5-6-31-16(8-21)11-29)27-17(28-30)14-9-25-19(26-10-14)20(22,23)24/h9-10,12-13,15-16H,3-8,11H2,1-2H3 KXNAYDXZVDHFOV-UHFFFAOYSA-N 229735 (S)-2-(fluoromethyl)-4- ((1R,3S)-3-(1-isopropyl-3- (2-(trifluoromethyl)pyrim- idin-5-yl)-1H-1,2,4-triazol-5- yl)cyclopentyl)morpholine::US20260008775, Compound 161 7-dehydrocholesterol reductase Homo sapiens 89.3 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229735&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312782 336949218 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149401 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@@H](N3CCO[C@H](C)C3)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-21(27-20(28-30)14-6-15(10-26-9-14)22(23,24)25)19-17-7-16(8-18(17)19)29-4-5-31-13(3)11-29/h6,9-10,12-13,16-19H,4-5,7-8,11H2,1-3H3 KVTUAZJQVZLQLK-UHFFFAOYSA-N 229736 (R)-4-((1R,3s,5S,6R)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- 1,2,4-triazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-2-meth- ylmorpholine::US20260008775, Compound 162 7-dehydrocholesterol reductase Homo sapiens 838 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229736&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312786 336949219 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149402 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)nc1[C@H]1[C@@H]2C[C@H](N3CCO[C@H](C)C3)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-21(27-20(28-30)14-6-15(10-26-9-14)22(23,24)25)19-17-7-16(8-18(17)19)29-4-5-31-13(3)11-29/h6,9-10,12-13,16-19H,4-5,7-8,11H2,1-3H3 KVTUAZJQVZLQLK-UHFFFAOYSA-N 229737 (R)-4-((1R,3r,5S,6R)-6-(1- isopropyl-3-(5-(trifluoro- methyl)pyridin-3-yl)-1H- 1,2,4-triazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-2-meth- ylmorpholine::US20260008775, Compound 163 7-dehydrocholesterol reductase Homo sapiens 32.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229737 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229737&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 127053838 336949220 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149403 CC(C)n1nc([C@H]2CC[C@H](C(F)(F)F)CC2)nc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H35F3N4O/c1-13(2)30-22(27-21(28-30)15-4-6-16(7-5-15)23(24,25)26)20-18-10-17(11-19(18)20)29-8-9-31-12-14(29)3/h13-20H,4-12H2,1-3H3 FOBRBPMORQPWTA-UHFFFAOYSA-N 229738 (R)-4-((1R,3R,5S,6R)-6-(1- isopropyl-3-((1R,4R)-4- (trifluoromethyl)cyclohex- yl)-1H-1,2,4-triazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 3-methylmorpholine::US20260008775, Compound 164* 7-dehydrocholesterol reductase Homo sapiens 1640 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229738 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229738&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 101043344 336949221 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149404 CC(C)n1nc([C@H]2CC[C@H](C(F)(F)F)CC2)nc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H35F3N4O/c1-13(2)30-22(27-21(28-30)15-4-6-16(7-5-15)23(24,25)26)20-18-10-17(11-19(18)20)29-8-9-31-12-14(29)3/h13-20H,4-12H2,1-3H3 FOBRBPMORQPWTA-UHFFFAOYSA-N 229739 (R)-4-((1R,3S,5S,6R)-6-(1- isopropyl-3-((1R,4R)-4- (trifluoromethyl)cyclohexyl)- 1H-1,2,4-triazol-5-yl)bicyclo- [3.1.0]hexan-3-yl)-3-methyl- morpholine::US20260008775, Compound 165* 7-dehydrocholesterol reductase Homo sapiens 40.4 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229739 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229739&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312571 336949222 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149405 CC(C)n1nc([C@H]2CC[C@@H](C(F)(F)F)CC2)nc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H35F3N4O/c1-13(2)30-22(27-21(28-30)15-4-6-16(7-5-15)23(24,25)26)20-18-10-17(11-19(18)20)29-8-9-31-12-14(29)3/h13-20H,4-12H2,1-3H3 FOBRBPMORQPWTA-UHFFFAOYSA-N 229740 (R)-4-((1R,3R,5S,6R)-6-(1- isopropyl-3-((1s,4S)-4- (trifluoromethyl)cyclohexyl)- 1H-1,2,4-triazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-3-methyl- morpholine::US20260008775, Compound 166* 7-dehydrocholesterol reductase Homo sapiens 41.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229740 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229740&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312793 336949223 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149406 CC(C)n1nc([C@H]2CC[C@@H](C(F)(F)F)CC2)nc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C23H35F3N4O/c1-13(2)30-22(27-21(28-30)15-4-6-16(7-5-15)23(24,25)26)20-18-10-17(11-19(18)20)29-8-9-31-12-14(29)3/h13-20H,4-12H2,1-3H3 FOBRBPMORQPWTA-UHFFFAOYSA-N 229741 (R)-4-((1R,3S,5S,6R)-6-(1- isopropyl-3-((1s,4S)-4- (trifluoromethyl)cyclohexyl)- 1H-1,2,4-triazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-3-meth- ylmorpholine::US20260008775, Compound 167* 7-dehydrocholesterol reductase Homo sapiens 25.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229741 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229741&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312613 336949224 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149407 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@H]1CC[C@H](N2CCO[C@H](CF)C2)C1 InChI=1S/C21H27F4N5O/c1-13(2)30-20(14-3-5-16(9-14)29-7-8-31-17(10-22)12-29)27-19(28-30)15-4-6-18(26-11-15)21(23,24)25/h4,6,11,13-14,16-17H,3,5,7-10,12H2,1-2H3 IRFPWAVREHQVEQ-UHFFFAOYSA-N 229742 (S)-2-(fluoromethyl)-4- ((1S,3S)-3-(1-isopropyl-3-(6- (trifluoromethyl)pyridin-3- yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 168 7-dehydrocholesterol reductase Homo sapiens 388 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229742 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229742&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312752 336949225 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149408 CC(C)n1nc(-c2ccc(C(F)(F)F)nc2)nc1[C@H]1CC[C@@H](N2CCO[C@H](CF)C2)C1 InChI=1S/C21H27F4N5O/c1-13(2)30-20(14-3-5-16(9-14)29-7-8-31-17(10-22)12-29)27-19(28-30)15-4-6-18(26-11-15)21(23,24)25/h4,6,11,13-14,16-17H,3,5,7-10,12H2,1-2H3 IRFPWAVREHQVEQ-UHFFFAOYSA-N 229743 (S)-2-(fluoromethyl)-4- ((1R,3S)-3-(1-isopropyl-3- (6-(trifluoromethyl)pyridin- 3-yl)-1H-1,2,4-triazol-5-yl)- cyclopentyl)morpholine::US20260008775, Compound 169 7-dehydrocholesterol reductase Homo sapiens 30.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229743 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229743&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312699 336949226 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149409 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCOCC3)C[C@@H]21 InChI=1S/C23H28F3N3O/c1-14(2)29-21(13-20(27-29)15-4-3-5-16(10-15)23(24,25)26)22-18-11-17(12-19(18)22)28-6-8-30-9-7-28/h3-5,10,13-14,17-19,22H,6-9,11-12H2,1-2H3 PDILAMYHHNWXND-UHFFFAOYSA-N 229744 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(3-(trifluorometh- yl)phenyl)-1H-pyrazol-5- yl)bicyclo[3.1.0]hexan-3-yl)- morpholine::US20260008775, Compound 170 7-dehydrocholesterol reductase Homo sapiens 6.87 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229744 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229744&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 67353768 336949227 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149410 CC(C)n1nc(-c2cc(C(F)(F)F)ncn2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(8-18(28-30)17-9-20(22(23,24)25)27-11-26-17)21-15-6-14(7-16(15)21)29-4-5-31-10-13(29)3/h8-9,11-16,21H,4-7,10H2,1-3H3 IPCGPOZOPIYPAO-UHFFFAOYSA-N 229683 (R)-4-((1R,3s,5S,6R)-6-(1- isopropyl-3-(6-(trifluoro- methyl)pyrimidin-4-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-3-methylmor- pholine::US20260008775, Compound 202 7-dehydrocholesterol reductase Homo sapiens 188 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229683 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229683&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 53373537 336949168 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149411 CC(C)n1nc(-c2ccnc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCOCC3)C[C@@H]21 InChI=1S/C22H27F3N4O/c1-13(2)29-19(12-18(27-29)14-3-4-26-20(9-14)22(23,24)25)21-16-10-15(11-17(16)21)28-5-7-30-8-6-28/h3-4,9,12-13,15-17,21H,5-8,10-11H2,1-2H3 NCKKMRNALMGTPF-UHFFFAOYSA-N 229745 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(2-(trifluorometh- yl)pyridin-4-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)morpholine::US20260008775, Compound 172 7-dehydrocholesterol reductase Homo sapiens 13.4 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229745 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229745&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312696 336949228 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149412 CC(C)n1nc(-c2ccc(C(F)(F)F)cc2)cc1[C@H]1[C@@H]2C[C@H](N3CCOCC3)C[C@@H]21 InChI=1S/C23H28F3N3O/c1-14(2)29-21(13-20(27-29)15-3-5-16(6-4-15)23(24,25)26)22-18-11-17(12-19(18)22)28-7-9-30-10-8-28/h3-6,13-14,17-19,22H,7-12H2,1-2H3 JSTCRIPOMABNDU-UHFFFAOYSA-N 229746 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(4-(trifluorometh- yl)phenyl)-1H-5-yl)bicyclo [3.1.0]hexan-3-yl)morpholine::US20260008775, Compound 173 7-dehydrocholesterol reductase Homo sapiens 7.81 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229746 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229746&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312610 336949229 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149413 CC(C)n1nc(-c2ccc(C(F)(F)F)cn2)cc1[C@H]1[C@@H]2C[C@H](N3CCOCC3)C[C@@H]21 InChI=1S/C22H27F3N4O/c1-13(2)29-20(11-19(27-29)18-4-3-14(12-26-18)22(23,24)25)21-16-9-15(10-17(16)21)28-5-7-30-8-6-28/h3-4,11-13,15-17,21H,5-10H2,1-2H3 ISAHGBGVKUIRLU-UHFFFAOYSA-N 229747 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(5-(trifluorometh- yl)pyridin-2-yl)-1H-pyrazol- 5-yl)bicyclo[3.1.0]hexan-3- yl)morpholine::US20260008775, Compound 174 7-dehydrocholesterol reductase Homo sapiens 38.3 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229747 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229747&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312711 336949230 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149414 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30F3N3O/c1-15(2)30-22(14-21(28-30)16-5-3-6-17(11-16)24(25,26)27)23-19-12-18(13-20(19)23)29-7-4-9-31-10-8-29/h3,5-6,11,14-15,18-20,23H,4,7-10,12-13H2,1-2H3 PTAURTMDFUCKQZ-UHFFFAOYSA-N 229748 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(3-(trifluorometh- yl)phenyl)-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 175* 7-dehydrocholesterol reductase Homo sapiens 14.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229748 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229748&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 127053839 336949231 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149415 CC(C)n1nc(-c2cccc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30F3N3O/c1-15(2)30-22(14-21(28-30)16-5-3-6-17(11-16)24(25,26)27)23-19-12-18(13-20(19)23)29-7-4-9-31-10-8-29/h3,5-6,11,14-15,18-20,23H,4,7-10,12-13H2,1-2H3 PTAURTMDFUCKQZ-UHFFFAOYSA-N 229749 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(3-(trifluorometh- yl)phenyl)-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 176* 7-dehydrocholesterol reductase Homo sapiens 8.64 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229749 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229749&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312763 336949232 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149416 CC(C)n1nc(-c2cncc(Cl)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H29ClN4O/c1-14(2)27-21(11-20(25-27)15-8-16(23)13-24-12-15)22-18-9-17(10-19(18)22)26-4-3-6-28-7-5-26/h8,11-14,17-19,22H,3-7,9-10H2,1-2H3 OPCAPQWNSHQEAQ-UHFFFAOYSA-N 229750 4-((1R,3s,5S,6r)-6-(3-(5- chloropyridin-3-yl)-1-iso- propyl-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 177* 7-dehydrocholesterol reductase Homo sapiens 15.5 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229750 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229750&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312608 336949233 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149417 CC(C)n1nc(-c2cncc(Cl)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H29ClN4O/c1-14(2)27-21(11-20(25-27)15-8-16(23)13-24-12-15)22-18-9-17(10-19(18)22)26-4-3-6-28-7-5-26/h8,11-14,17-19,22H,3-7,9-10H2,1-2H3 OPCAPQWNSHQEAQ-UHFFFAOYSA-N 229751 4-((1R,3r,5S,6r)-6-(3-(5- chloropyridin-3-yl)-1-iso- propyl-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 178* 7-dehydrocholesterol reductase Homo sapiens 35.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229751 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229751&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312758 336949234 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149418 CC(C)n1nc(-c2ccc(C#N)cc2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30N4O/c1-16(2)28-23(14-22(26-28)18-6-4-17(15-25)5-7-18)24-20-12-19(13-21(20)24)27-8-3-10-29-11-9-27/h4-7,14,16,19-21,24H,3,8-13H2,1-2H3 SFRGQMHVKPFBNK-UHFFFAOYSA-N 229752 4-(5-((1R,3r,5S,6r)-3-(1,4- oxazepan-4-yl)bicyclo[3.1.0] hexan-6-yl)-1-isopropyl-1H- pyrazol-3-yl)benzonitrile::US20260008775, Compound 179* 7-dehydrocholesterol reductase Homo sapiens 10.9 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229752 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229752&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312762 336949235 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149419 CC(C)n1nc(-c2ccc(C#N)cc2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30N4O/c1-16(2)28-23(14-22(26-28)18-6-4-17(15-25)5-7-18)24-20-12-19(13-21(20)24)27-8-3-10-29-11-9-27/h4-7,14,16,19-21,24H,3,8-13H2,1-2H3 SFRGQMHVKPFBNK-UHFFFAOYSA-N 229753 4-(5-((1R,3s,5S,6r)-3-(1,4- oxazepan-4-yl)bicyclo[3.1.0] hexan-6-yl)-1-isopropyl-1H- pyrazol-3-yl)benzonitrile::US20260008775, Compound 180* 7-dehydrocholesterol reductase Homo sapiens 30.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229753 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229753&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312666 336949236 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149420 CC(C)n1nc(-c2ccc(C(F)(F)F)cc2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30F3N3O/c1-15(2)30-22(14-21(28-30)16-4-6-17(7-5-16)24(25,26)27)23-19-12-18(13-20(19)23)29-8-3-10-31-11-9-29/h4-7,14-15,18-20,23H,3,8-13H2,1-2H3 HOFPHPYIJOUHTO-UHFFFAOYSA-N 229754 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(4-(trifluorometh- yl)phenyl)-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 181* 7-dehydrocholesterol reductase Homo sapiens 10.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229754 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229754&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312662 336949237 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149421 CC(C)n1nc(-c2ccc(C(F)(F)F)cc2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30F3N3O/c1-15(2)30-22(14-21(28-30)16-4-6-17(7-5-16)24(25,26)27)23-19-12-18(13-20(19)23)29-8-3-10-31-11-9-29/h4-7,14-15,18-20,23H,3,8-13H2,1-2H3 HOFPHPYIJOUHTO-UHFFFAOYSA-N 229755 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(4-(trifluorometh- yl)phenyl)-1H-pyrazol-5- yl)bicyclo[3.1.0]hexan-3- yl)-1,4-oxazepane::US20260008775, Compound 182* 7-dehydrocholesterol reductase Homo sapiens 15.8 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229755 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229755&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312687 336949238 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149422 CC(C)n1nc(-c2ccc(F)cc2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H30FN3O/c1-15(2)27-22(14-21(25-27)16-4-6-17(24)7-5-16)23-19-12-18(13-20(19)23)26-8-3-10-28-11-9-26/h4-7,14-15,18-20,23H,3,8-13H2,1-2H3 BUZFCAJPQUOJAX-UHFFFAOYSA-N 229756 4-((1R,3r,5S,6r)-6-(3-(4- fluorophenyl)-1-isopropyl- 1H-pyrazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-1,4- oxazepane::US20260008775, Compound 183* 7-dehydrocholesterol reductase Homo sapiens 10.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229756 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229756&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312689 336949239 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149423 CC(C)n1nc(-c2ccc(F)cc2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H30FN3O/c1-15(2)27-22(14-21(25-27)16-4-6-17(24)7-5-16)23-19-12-18(13-20(19)23)26-8-3-10-28-11-9-26/h4-7,14-15,18-20,23H,3,8-13H2,1-2H3 BUZFCAJPQUOJAX-UHFFFAOYSA-N 229757 4-((1R,3s,5S,6r)-6-(3-(4- fluorophenyl)-1-isopropyl- 1H-pyrazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-1,4- oxazepane::US20260008775, Compound 184* 7-dehydrocholesterol reductase Homo sapiens 21.3 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229757 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229757&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312759 336949240 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149424 CC(C)n1nc(-c2ccc(OC(F)(F)F)cc2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30F3N3O2/c1-15(2)30-22(14-21(28-30)16-4-6-18(7-5-16)32-24(25,26)27)23-19-12-17(13-20(19)23)29-8-3-10-31-11-9-29/h4-7,14-15,17,19-20,23H,3,8-13H2,1-2H3 LTZYPJHANRRVRW-UHFFFAOYSA-N 229758 4-((1R,3r,5S,6r)-6-(1- isopropyl-3-(4-(trifluoro- methoxy)phenyl)-1H-pyr- azol-5-yl)bicyclo[3.1.0] hexan-3-yl)-1,4-oxazepane::US20260008775, Compound 185* 7-dehydrocholesterol reductase Homo sapiens 12.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229758 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229758&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312774 336949241 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149425 CC(C)n1nc(-c2ccc(OC(F)(F)F)cc2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30F3N3O2/c1-15(2)30-22(14-21(28-30)16-4-6-18(7-5-16)32-24(25,26)27)23-19-12-17(13-20(19)23)29-8-3-10-31-11-9-29/h4-7,14-15,17,19-20,23H,3,8-13H2,1-2H3 LTZYPJHANRRVRW-UHFFFAOYSA-N 229759 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(4-(trifluorometh- oxy)phenyl)-1H-pyrazol-5- yl)bicyclo[3.1.0]hexan-3- yl)-1,4-oxazepane::US20260008775, Compound 186* 7-dehydrocholesterol reductase Homo sapiens 20.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229759 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229759&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312803 336949242 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149426 CC(C)n1nc(-c2cncc(F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H29FN4O/c1-14(2)27-21(11-20(25-27)15-8-16(23)13-24-12-15)22-18-9-17(10-19(18)22)26-4-3-6-28-7-5-26/h8,11-14,17-19,22H,3-7,9-10H2,1-2H3 DCOBMZFLFWHJHC-UHFFFAOYSA-N 229760 4-((1R,3r,5S,6r)-6-(3-(5- fluoropyridin-3-yl)-1-iso- propyl-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 187* 7-dehydrocholesterol reductase Homo sapiens 20.3 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229760 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229760&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312742 336949243 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149427 CC(C)n1nc(-c2cncc(F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C22H29FN4O/c1-14(2)27-21(11-20(25-27)15-8-16(23)13-24-12-15)22-18-9-17(10-19(18)22)26-4-3-6-28-7-5-26/h8,11-14,17-19,22H,3-7,9-10H2,1-2H3 DCOBMZFLFWHJHC-UHFFFAOYSA-N 229761 4-((1R,3s,5S,6r)-6-(3-(5- fluoropyridin-3-yl)-1-iso- propyl-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 188* 7-dehydrocholesterol reductase Homo sapiens 169 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229761&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312638 336949244 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149428 CC(C)n1nc(-c2cccc(OC(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30F3N3O2/c1-15(2)30-22(14-21(28-30)16-5-3-6-18(11-16)32-24(25,26)27)23-19-12-17(13-20(19)23)29-7-4-9-31-10-8-29/h3,5-6,11,14-15,17,19-20,23H,4,7-10,12-13H2,1-2H3 LONGSIWCXBXLDQ-UHFFFAOYSA-N 229762 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(3-(trifluorometh- oxy)phenyl)-1H-pyrazol-5- yl)bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 189* 7-dehydrocholesterol reductase Homo sapiens 9.14 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229762 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229762&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312603 336949245 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149429 CC(C)n1nc(-c2cccc(OC(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30F3N3O2/c1-15(2)30-22(14-21(28-30)16-5-3-6-18(11-16)32-24(25,26)27)23-19-12-17(13-20(19)23)29-7-4-9-31-10-8-29/h3,5-6,11,14-15,17,19-20,23H,4,7-10,12-13H2,1-2H3 LONGSIWCXBXLDQ-UHFFFAOYSA-N 229763 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(3-(trifluorometh- oxy)phenyl)-1H-pyrazol-5- yl)bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 190* 7-dehydrocholesterol reductase Homo sapiens 9.63 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229763&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312777 336949246 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149430 CC(C)n1nc(-c2cccc(C#N)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30N4O/c1-16(2)28-23(14-22(26-28)18-6-3-5-17(11-18)15-25)24-20-12-19(13-21(20)24)27-7-4-9-29-10-8-27/h3,5-6,11,14,16,19-21,24H,4,7-10,12-13H2,1-2H3 YAOCIFXRVWGFOX-UHFFFAOYSA-N 229764 3-(5-((1R,3r,5S,6r)-3-(1,4- oxazepan-4-yl)bicyclo[3.1.0] hexan-6-yl)-1-isopropyl-1H- pyrazol-3-yl)benzonitrile::US20260008775, Compound 191* 7-dehydrocholesterol reductase Homo sapiens 8.04 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229764&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312651 336949247 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149431 CC(C)n1nc(-c2cccc(C#N)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H30N4O/c1-16(2)28-23(14-22(26-28)18-6-3-5-17(11-18)15-25)24-20-12-19(13-21(20)24)27-7-4-9-29-10-8-27/h3,5-6,11,14,16,19-21,24H,4,7-10,12-13H2,1-2H3 YAOCIFXRVWGFOX-UHFFFAOYSA-N 229765 3-(5-((1R,3s,5S,6r)-3-(1,4- oxazepan-4-yl)bicyclo[3.1.0] hexan-6-yl)-1-isopropyl-1H- pyrazol-3-yl)benzonitrile::US20260008775, Compound 192* 7-dehydrocholesterol reductase Homo sapiens 12.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229765 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229765&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312665 336949248 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149432 CC(C)n1nc(-c2ccccc2F)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H30FN3O/c1-15(2)27-22(14-21(25-27)17-6-3-4-7-20(17)24)23-18-12-16(13-19(18)23)26-8-5-10-28-11-9-26/h3-4,6-7,14-16,18-19,23H,5,8-13H2,1-2H3 AYKDXVAEOOQTSI-UHFFFAOYSA-N 229766 4-((1R,3r,5S,6r)-6-(3-(2- fluorophenyl)-1-isopropyl- 1H-pyrazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-1,4- oxazepane::US20260008775, Compound 193* 7-dehydrocholesterol reductase Homo sapiens 7.29 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229766&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312796 336949249 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149433 CC(C)n1nc(-c2ccccc2F)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H30FN3O/c1-15(2)27-22(14-21(25-27)17-6-3-4-7-20(17)24)23-18-12-16(13-19(18)23)26-8-5-10-28-11-9-26/h3-4,6-7,14-16,18-19,23H,5,8-13H2,1-2H3 AYKDXVAEOOQTSI-UHFFFAOYSA-N 229767 4-((1R,3s,5S,6r)-6-(3-(2- fluorophenyl)-1-isopropyl- 1H-pyrazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-1,4- oxazepane::US20260008775, Compound 194* 7-dehydrocholesterol reductase Homo sapiens 13.1 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229767 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229767&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312660 336949250 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149434 CC(C)n1nc(-c2cccc(F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H30FN3O/c1-15(2)27-22(14-21(25-27)16-5-3-6-17(24)11-16)23-19-12-18(13-20(19)23)26-7-4-9-28-10-8-26/h3,5-6,11,14-15,18-20,23H,4,7-10,12-13H2,1-2H3 GIANHJVWLRPLFK-UHFFFAOYSA-N 229768 4-((1R,3r,5S,6r)-6-(3-(3- fluorophenyl)-1-isopropyl- 1H-pyrazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-1,4- oxazepane::US20260008775, Compound 195* 7-dehydrocholesterol reductase Homo sapiens 12.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229768&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312630 336949251 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149435 CC(C)n1nc(-c2cccc(F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H30FN3O/c1-15(2)27-22(14-21(25-27)16-5-3-6-17(24)11-16)23-19-12-18(13-20(19)23)26-7-4-9-28-10-8-26/h3,5-6,11,14-15,18-20,23H,4,7-10,12-13H2,1-2H3 GIANHJVWLRPLFK-UHFFFAOYSA-N 229769 4-((1R,3s,5S,6r)-6-(3-(3- fluorophenyl)-1-isopropyl- 1H-pyrazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-1,4- oxazepane::US20260008775, Compound 196* 7-dehydrocholesterol reductase Homo sapiens 12.7 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229769 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229769&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312614 336949252 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149436 Cc1ccccc1-c1cc([C@H]2[C@@H]3C[C@H](N4CCCOCC4)C[C@@H]32)n(C(C)C)n1 InChI=1S/C24H33N3O/c1-16(2)27-23(15-22(25-27)19-8-5-4-7-17(19)3)24-20-13-18(14-21(20)24)26-9-6-11-28-12-10-26/h4-5,7-8,15-16,18,20-21,24H,6,9-14H2,1-3H3 OWEJXOARTCJZQP-UHFFFAOYSA-N 229770 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(o-tolyl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-1,4-oxazepane::US20260008775, Compound 197* 7-dehydrocholesterol reductase Homo sapiens 9.87 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229770 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229770&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312644 336949253 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149437 Cc1ccccc1-c1cc([C@H]2[C@@H]3C[C@@H](N4CCCOCC4)C[C@@H]32)n(C(C)C)n1 InChI=1S/C24H33N3O/c1-16(2)27-23(15-22(25-27)19-8-5-4-7-17(19)3)24-20-13-18(14-21(20)24)26-9-6-11-28-12-10-26/h4-5,7-8,15-16,18,20-21,24H,6,9-14H2,1-3H3 OWEJXOARTCJZQP-UHFFFAOYSA-N 229771 4-((1R,3s,5S,6r)-6-(1-iso- propyl-3-(o-tolyl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)-1,4-oxazepane::US20260008775, Compound 198* 7-dehydrocholesterol reductase Homo sapiens 20.2 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229771 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229771&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312642 336949254 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149438 CC(C)n1nc(-c2cccc(OC(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H31F2N3O2/c1-15(2)29-22(14-21(27-29)16-5-3-6-18(11-16)31-24(25)26)23-19-12-17(13-20(19)23)28-7-4-9-30-10-8-28/h3,5-6,11,14-15,17,19-20,23-24H,4,7-10,12-13H2,1-2H3 BYHXGMRPJNNKLO-UHFFFAOYSA-N 229772 4-((1R,3r,5S,6r)-6-(3-(3- (difluoromethoxy)phenyl)-1- isopropyl-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 199* 7-dehydrocholesterol reductase Homo sapiens 8.20 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229772 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229772&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312707 336949255 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149439 CC(C)n1nc(-c2cccc(OC(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H31F2N3O2/c1-15(2)29-22(14-21(27-29)16-5-3-6-18(11-16)31-24(25)26)23-19-12-17(13-20(19)23)28-7-4-9-30-10-8-28/h3,5-6,11,14-15,17,19-20,23-24H,4,7-10,12-13H2,1-2H3 BYHXGMRPJNNKLO-UHFFFAOYSA-N 229773 4-((1R,3s,5S,6r)-6-(3-(3- (difluoromethoxy)phenyl)-1- isopropyl-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 200* 7-dehydrocholesterol reductase Homo sapiens 11.6 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229773 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229773&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312735 336949256 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149440 CC(C)n1nc(-c2ccc(OC(F)F)cc2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C24H31F2N3O2/c1-15(2)29-22(14-21(27-29)16-4-6-18(7-5-16)31-24(25)26)23-19-12-17(13-20(19)23)28-8-3-10-30-11-9-28/h4-7,14-15,17,19-20,23-24H,3,8-13H2,1-2H3 XPMDNMHDHONDRT-UHFFFAOYSA-N 229774 4-((1R,3r,5S,6r)-6-(3-(4- (difluoromethoxy)phenyl)-1- isopropyl-1H-pyrazol-5-yl)- bicyclo[3.1.0]hexan-3-yl)- 1,4-oxazepane::US20260008775, Compound 201* 7-dehydrocholesterol reductase Homo sapiens 11.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229774 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229774&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312731 336949257 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149441 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)cc1[C@H]1[C@@H]2C[C@H](N3CCOCC3)C[C@@H]21 InChI=1S/C21H26F3N5O/c1-12(2)29-18(9-17(27-29)13-10-25-20(26-11-13)21(22,23)24)19-15-7-14(8-16(15)19)28-3-5-30-6-4-28/h9-12,14-16,19H,3-8H2,1-2H3 CACXEFLAJKRSAQ-UHFFFAOYSA-N 229775 4-((1R,3r,5S,6r)-6-(1-iso- propyl-3-(2-(trifluorometh- yl)pyrimidin-5-yl)-1H- pyrazol-5-yl)bicyclo[3.1.0] hexan-3-yl)morpholine::US20260008775, Compound 203 7-dehydrocholesterol reductase Homo sapiens 27.5 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229775 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229775&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312712 336949258 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149442 CC(C)n1nc(-c2cnc(C(F)(F)F)nc2)nc1[C@H]1[C@@H]2C[C@H](N3CCOC[C@H]3C)C[C@@H]21 InChI=1S/C21H27F3N6O/c1-11(2)30-19(27-18(28-30)13-8-25-20(26-9-13)21(22,23)24)17-15-6-14(7-16(15)17)29-4-5-31-10-12(29)3/h8-9,11-12,14-17H,4-7,10H2,1-3H3 WUEKGVGCVKRXMK-UHFFFAOYSA-N 229776 (R)-4-((1R,3r,5S,6r)-6-(1- isopropyl-3-(2-(trifluoro- methyl)pyrimidin-5-yl)-1H- 1,2,4-triazol-5-yl)bicyclo [3.1.0]hexan-3-yl)-3-methyl- morpholine::US20260008775, Compound 204 7-dehydrocholesterol reductase Homo sapiens 16.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229776 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229776&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312621 336949259 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149443 CC(C)n1nc(-c2cnc(N)c(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOCC3)C[C@@H]21 InChI=1S/C22H28F3N5O/c1-12(2)30-19(20-15-8-14(9-16(15)20)29-3-5-31-6-4-29)10-18(28-30)13-7-17(22(23,24)25)21(26)27-11-13/h7,10-12,14-16,20H,3-6,8-9H2,1-2H3,(H2,26,27) VHLSGRYMNVUONP-UHFFFAOYSA-N 229777 US20260008775, Example Table4.1 7-dehydrocholesterol reductase Homo sapiens 3670 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229777&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312619 336949260 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149444 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@@H](N3CCOCC3)C[C@@H]21 InChI=1S/C22H27F3N4O/c1-13(2)29-20(10-19(27-29)14-7-15(12-26-11-14)22(23,24)25)21-17-8-16(9-18(17)21)28-3-5-30-6-4-28/h7,10-13,16-18,21H,3-6,8-9H2,1-2H3 XPKXSTQRYGGSEW-UHFFFAOYSA-N 229778 US20260008775, Example Table4.2 7-dehydrocholesterol reductase Homo sapiens 188 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229778 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229778&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 121312674 336949261 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7 149445 CC(C)n1nc(-c2cncc(C(F)(F)F)c2)cc1[C@H]1[C@@H]2C[C@H](N3CCCOCC3)C[C@@H]21 InChI=1S/C23H29F3N4O/c1-14(2)30-21(11-20(28-30)15-8-16(13-27-12-15)23(24,25)26)22-18-9-17(10-19(18)22)29-4-3-6-31-7-5-29/h8,11-14,17-19,22H,3-7,9-10H2,1-2H3 YWJWEOLYECROGK-UHFFFAOYSA-N 229780 US20260008775, Example Table4.3 7-dehydrocholesterol reductase Homo sapiens 20.0 US Patent 10.7270/Q2TQ66C0 US20260008775 BRAUN, M; CASTANEDO, GM; DOREL, R; UNG, MU; VERNIER, W; VOLGRAF, M; CARRUTHERS, N 1/8/2026 5/21/2026 Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=229780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006184&target=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=229780&enzyme=7-dehydrocholesterol+reductase&column=ki&startPg=0&Increment=50&submit=Search 127053840 336949262 1 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 7-dehydrocholesterol reductase DHCR7_HUMAN Q9UBM7 B2R6Z2 O60492 O60717 7-dehydrocholesterol reductase A0A024R5F7_HUMAN A0A024R5F7