BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) koff (s-1) kon (M-1-s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 453756 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)[N+]([O-])=O)c1 InChI=1S/C16H14N2O6/c1-23-16(20)11-3-2-4-12(9-11)17-15(19)10-24-14-7-5-13(6-8-14)18(21)22/h2-9H,10H2,1H3,(H,17,19) JLVNYYOIHIEBOT-UHFFFAOYSA-N 50250241 CHEMBL4090211::US12630497, Compound 3-1 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250241&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 797770 401961974 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453757 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)[N+]([O-])=O)c1 InChI=1S/C16H14N2O6/c1-23-16(20)11-3-2-4-12(9-11)17-15(19)10-24-14-7-5-13(6-8-14)18(21)22/h2-9H,10H2,1H3,(H,17,19) JLVNYYOIHIEBOT-UHFFFAOYSA-N 50250241 CHEMBL4090211::US12630497, Compound 3-1 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250241&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 797770 401961974 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453758 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)C(F)(F)F)c1 InChI=1S/C17H14F3NO4/c1-24-16(23)11-3-2-4-13(9-11)21-15(22)10-25-14-7-5-12(6-8-14)17(18,19)20/h2-9H,10H2,1H3,(H,21,22) DBCMYCSOMJQUIU-UHFFFAOYSA-N 50250249 CHEMBL4073732::US12630497, Compound 3-2 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250249&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 45670606 401961982 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453759 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)C(F)(F)F)c1 InChI=1S/C17H14F3NO4/c1-24-16(23)11-3-2-4-13(9-11)21-15(22)10-25-14-7-5-12(6-8-14)17(18,19)20/h2-9H,10H2,1H3,(H,21,22) DBCMYCSOMJQUIU-UHFFFAOYSA-N 50250249 CHEMBL4073732::US12630497, Compound 3-2 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250249&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 45670606 401961982 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453760 COC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 InChI=1S/C20H23NO4/c1-20(2,3)15-8-10-17(11-9-15)25-13-18(22)21-16-7-5-6-14(12-16)19(23)24-4/h5-12H,13H2,1-4H3,(H,21,22) LHXXFQBRYJEMQO-UHFFFAOYSA-N 808046 Methyl 3-(2-(4-tert-butylphenoxy)acetamido)benzoate::US12630497, Compound 3-3 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808046&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 710360 533110480 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453761 COC(=O)c1cccc(NC(=O)COc2ccc(C(C)(C)C)cc2)c1 InChI=1S/C20H23NO4/c1-20(2,3)15-8-10-17(11-9-15)25-13-18(22)21-16-7-5-6-14(12-16)19(23)24-4/h5-12H,13H2,1-4H3,(H,21,22) LHXXFQBRYJEMQO-UHFFFAOYSA-N 808046 Methyl 3-(2-(4-tert-butylphenoxy)acetamido)benzoate::US12630497, Compound 3-3 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808046&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 710360 533110480 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453762 COC(=O)c1cccc(NC(=O)COc2ccc(C)cc2)c1 InChI=1S/C17H17NO4/c1-12-6-8-15(9-7-12)22-11-16(19)18-14-5-3-4-13(10-14)17(20)21-2/h3-10H,11H2,1-2H3,(H,18,19) FXMSEGHUPSBVNO-UHFFFAOYSA-N 50250240 CHEMBL4076058::US12630497, Compound 3-4 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250240&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 16392913 401961973 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453763 COC(=O)c1cccc(NC(=O)COc2ccc(C)cc2)c1 InChI=1S/C17H17NO4/c1-12-6-8-15(9-7-12)22-11-16(19)18-14-5-3-4-13(10-14)17(20)21-2/h3-10H,11H2,1-2H3,(H,18,19) FXMSEGHUPSBVNO-UHFFFAOYSA-N 50250240 CHEMBL4076058::US12630497, Compound 3-4 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250240&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 16392913 401961973 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453764 CCc1ccc(OCC(=O)Nc2cccc(c2)C(=O)OC)cc1 InChI=1S/C18H19NO4/c1-3-13-7-9-16(10-8-13)23-12-17(20)19-15-6-4-5-14(11-15)18(21)22-2/h4-11H,3,12H2,1-2H3,(H,19,20) NHQHUFPZVRJKEV-UHFFFAOYSA-N 50250216 CHEMBL4086585::US12630497, Compound 3-5 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250216&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 26240699 401961954 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453765 CCc1ccc(OCC(=O)Nc2cccc(c2)C(=O)OC)cc1 InChI=1S/C18H19NO4/c1-3-13-7-9-16(10-8-13)23-12-17(20)19-15-6-4-5-14(11-15)18(21)22-2/h4-11H,3,12H2,1-2H3,(H,19,20) NHQHUFPZVRJKEV-UHFFFAOYSA-N 50250216 CHEMBL4086585::US12630497, Compound 3-5 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250216&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 26240699 401961954 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453766 CCCc1ccc(OCC(=O)Nc2cccc(c2)C(=O)OC)cc1 InChI=1S/C19H21NO4/c1-3-5-14-8-10-17(11-9-14)24-13-18(21)20-16-7-4-6-15(12-16)19(22)23-2/h4,6-12H,3,5,13H2,1-2H3,(H,20,21) NFTHWXYOVNUYOL-UHFFFAOYSA-N 50250239 CHEMBL4089556::US12630497, Compound 3-6 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250239 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250239&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 108456470 401961972 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453767 CCCc1ccc(OCC(=O)Nc2cccc(c2)C(=O)OC)cc1 InChI=1S/C19H21NO4/c1-3-5-14-8-10-17(11-9-14)24-13-18(21)20-16-7-4-6-15(12-16)19(22)23-2/h4,6-12H,3,5,13H2,1-2H3,(H,20,21) NFTHWXYOVNUYOL-UHFFFAOYSA-N 50250239 CHEMBL4089556::US12630497, Compound 3-6 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250239 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250239&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 108456470 401961972 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453768 CCCCc1ccc(OCC(=O)Nc2cccc(c2)C(=O)OC)cc1 InChI=1S/C20H23NO4/c1-3-4-6-15-9-11-18(12-10-15)25-14-19(22)21-17-8-5-7-16(13-17)20(23)24-2/h5,7-13H,3-4,6,14H2,1-2H3,(H,21,22) XEDGRLJBPSBATA-UHFFFAOYSA-N 50250248 CHEMBL4078740::US12630497, Compound 3-7 Malate dehydrogenase, cytoplasmic Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250248 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250248&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137650786 401961981 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453769 CCCCc1ccc(OCC(=O)Nc2cccc(c2)C(=O)OC)cc1 InChI=1S/C20H23NO4/c1-3-4-6-15-9-11-18(12-10-15)25-14-19(22)21-17-8-5-7-16(13-17)20(23)24-2/h5,7-13H,3-4,6,14H2,1-2H3,(H,21,22) XEDGRLJBPSBATA-UHFFFAOYSA-N 50250248 CHEMBL4078740::US12630497, Compound 3-7 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250248 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250248&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137650786 401961981 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453770 CCCCCc1ccc(OCC(=O)Nc2cccc(c2)C(=O)OC)cc1 InChI=1S/C21H25NO4/c1-3-4-5-7-16-10-12-19(13-11-16)26-15-20(23)22-18-9-6-8-17(14-18)21(24)25-2/h6,8-14H,3-5,7,15H2,1-2H3,(H,22,23) HDBDOZJTIIABKV-UHFFFAOYSA-N 50250238 CHEMBL4085170::US12630497, Compound 3-8 Malate dehydrogenase, cytoplasmic Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250238 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250238&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137648461 401961971 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453771 CCCCCc1ccc(OCC(=O)Nc2cccc(c2)C(=O)OC)cc1 InChI=1S/C21H25NO4/c1-3-4-5-7-16-10-12-19(13-11-16)26-15-20(23)22-18-9-6-8-17(14-18)21(24)25-2/h6,8-14H,3-5,7,15H2,1-2H3,(H,22,23) HDBDOZJTIIABKV-UHFFFAOYSA-N 50250238 CHEMBL4085170::US12630497, Compound 3-8 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250238 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250238&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137648461 401961971 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453772 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)C2CCCC2)c1 InChI=1S/C21H23NO4/c1-25-21(24)17-7-4-8-18(13-17)22-20(23)14-26-19-11-9-16(10-12-19)15-5-2-3-6-15/h4,7-13,15H,2-3,5-6,14H2,1H3,(H,22,23) BXGIDUPEWAJWHP-UHFFFAOYSA-N 50250237 CHEMBL4067849::US12630497, Compound 3-9 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250237 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250237&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135325012 401961970 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453773 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)C2CCCC2)c1 InChI=1S/C21H23NO4/c1-25-21(24)17-7-4-8-18(13-17)22-20(23)14-26-19-11-9-16(10-12-19)15-5-2-3-6-15/h4,7-13,15H,2-3,5-6,14H2,1H3,(H,22,23) BXGIDUPEWAJWHP-UHFFFAOYSA-N 50250237 CHEMBL4067849::US12630497, Compound 3-9 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250237 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250237&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135325012 401961970 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453774 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)C2CCCCC2)c1 InChI=1S/C22H25NO4/c1-26-22(25)18-8-5-9-19(14-18)23-21(24)15-27-20-12-10-17(11-13-20)16-6-3-2-4-7-16/h5,8-14,16H,2-4,6-7,15H2,1H3,(H,23,24) FTFFPYAMQKBSAI-UHFFFAOYSA-N 50250250 CHEMBL4087563::US12630497, Compound 3-10 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250250 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250250&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135324700 401961983 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453775 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)C2CCCCC2)c1 InChI=1S/C22H25NO4/c1-26-22(25)18-8-5-9-19(14-18)23-21(24)15-27-20-12-10-17(11-13-20)16-6-3-2-4-7-16/h5,8-14,16H,2-4,6-7,15H2,1H3,(H,23,24) FTFFPYAMQKBSAI-UHFFFAOYSA-N 50250250 CHEMBL4087563::US12630497, Compound 3-10 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250250 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250250&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135324700 401961983 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453776 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C24H31NO4/c1-23(2,3)16-24(4,5)18-10-12-20(13-11-18)29-15-21(26)25-19-9-7-8-17(14-19)22(27)28-6/h7-14H,15-16H2,1-6H3,(H,25,26) KNUYQRFVMMPPCC-UHFFFAOYSA-N 50250236 CHEMBL4105436::US12630497, Compound 3-11 Malate dehydrogenase, cytoplasmic Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250236 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250236&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135325076 401961969 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453777 COC(=O)c1cccc(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C24H31NO4/c1-23(2,3)16-24(4,5)18-10-12-20(13-11-18)29-15-21(26)25-19-9-7-8-17(14-19)22(27)28-6/h7-14H,15-16H2,1-6H3,(H,25,26) KNUYQRFVMMPPCC-UHFFFAOYSA-N 50250236 CHEMBL4105436::US12630497, Compound 3-11 Malate dehydrogenase, mitochondrial Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250236 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250236&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135325076 401961969 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453778 COC(=O)c1ccc(O)c(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C24H31NO5/c1-23(2,3)15-24(4,5)17-8-10-18(11-9-17)30-14-21(27)25-19-13-16(22(28)29-6)7-12-20(19)26/h7-13,26H,14-15H2,1-6H3,(H,25,27) SGXILMMYXOSMCZ-UHFFFAOYSA-N 50250235 CHEMBL4065526::US12630497, Compound 3-12 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250235&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135324895 401961968 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453779 COC(=O)c1ccc(O)c(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C24H31NO5/c1-23(2,3)15-24(4,5)17-8-10-18(11-9-17)30-14-21(27)25-19-13-16(22(28)29-6)7-12-20(19)26/h7-13,26H,14-15H2,1-6H3,(H,25,27) SGXILMMYXOSMCZ-UHFFFAOYSA-N 50250235 CHEMBL4065526::US12630497, Compound 3-12 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250235&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135324895 401961968 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453780 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)Nc2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C23H28F3NO2/c1-21(2,3)15-22(4,5)16-8-12-19(13-9-16)29-14-20(28)27-18-10-6-17(7-11-18)23(24,25)26/h6-13H,14-15H2,1-5H3,(H,27,28) VVVXRZQDARGUSJ-UHFFFAOYSA-N 50250227 CHEMBL4073085::US12630497, Compound 3-13 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250227 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250227&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135324917 401961964 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453781 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)Nc2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C23H28F3NO2/c1-21(2,3)15-22(4,5)16-8-12-19(13-9-16)29-14-20(28)27-18-10-6-17(7-11-18)23(24,25)26/h6-13H,14-15H2,1-5H3,(H,27,28) VVVXRZQDARGUSJ-UHFFFAOYSA-N 50250227 CHEMBL4073085::US12630497, Compound 3-13 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250227 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250227&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135324917 401961964 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453782 CN1CCN(CC1)c1ccc(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)cc1 InChI=1S/C27H39N3O2/c1-26(2,3)20-27(4,5)21-7-13-24(14-8-21)32-19-25(31)28-22-9-11-23(12-10-22)30-17-15-29(6)16-18-30/h7-14H,15-20H2,1-6H3,(H,28,31) NVLQSOCYRQWYEF-UHFFFAOYSA-N 50250226 CHEMBL4099949::US12630497, Compound 3-14 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250226&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135325022 401961963 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453783 CN1CCN(CC1)c1ccc(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)cc1 InChI=1S/C27H39N3O2/c1-26(2,3)20-27(4,5)21-7-13-24(14-8-21)32-19-25(31)28-22-9-11-23(12-10-22)30-17-15-29(6)16-18-30/h7-14H,15-20H2,1-6H3,(H,28,31) NVLQSOCYRQWYEF-UHFFFAOYSA-N 50250226 CHEMBL4099949::US12630497, Compound 3-14 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250226&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135325022 401961963 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453784 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1 InChI=1S/C28H37F3N2O2/c1-26(2,3)20-27(4,5)22-10-12-24(13-11-22)35-19-25(34)33-16-14-32(15-17-33)18-21-6-8-23(9-7-21)28(29,30)31/h6-13H,14-20H2,1-5H3 CRZVLUCELMROJU-UHFFFAOYSA-N 50250245 CHEMBL4086789::US12630497, Compound 3-15 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250245&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135324763 401961978 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453785 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1 InChI=1S/C28H37F3N2O2/c1-26(2,3)20-27(4,5)22-10-12-24(13-11-22)35-19-25(34)33-16-14-32(15-17-33)18-21-6-8-23(9-7-21)28(29,30)31/h6-13H,14-20H2,1-5H3 CRZVLUCELMROJU-UHFFFAOYSA-N 50250245 CHEMBL4086789::US12630497, Compound 3-15 Malate dehydrogenase, mitochondrial Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250245&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135324763 401961978 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453786 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)N2CCN(CC#C)CC2)cc1 InChI=1S/C23H34N2O2/c1-7-12-24-13-15-25(16-14-24)21(26)17-27-20-10-8-19(9-11-20)23(5,6)18-22(2,3)4/h1,8-11H,12-18H2,2-6H3 MQIACUGYVWHSCU-UHFFFAOYSA-N 50250225 CHEMBL4060357::US12630497, Compound 3-16 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250225&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137634500 401961962 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453787 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)N2CCN(CC#C)CC2)cc1 InChI=1S/C23H34N2O2/c1-7-12-24-13-15-25(16-14-24)21(26)17-27-20-10-8-19(9-11-20)23(5,6)18-22(2,3)4/h1,8-11H,12-18H2,2-6H3 MQIACUGYVWHSCU-UHFFFAOYSA-N 50250225 CHEMBL4060357::US12630497, Compound 3-16 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250225&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137634500 401961962 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453788 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)Nc2cc(ccc2O)C(=O)OCC#C)cc1 InChI=1S/C26H31NO5/c1-7-14-31-24(30)18-8-13-22(28)21(15-18)27-23(29)16-32-20-11-9-19(10-12-20)26(5,6)17-25(2,3)4/h1,8-13,15,28H,14,16-17H2,2-6H3,(H,27,29) DAQJYTKXJDLEKN-UHFFFAOYSA-N 50250223 CHEMBL4096306::US12630497, Compound 3-17 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250223 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250223&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137655939 401961961 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453789 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)Nc2cc(ccc2O)C(=O)OCC#C)cc1 InChI=1S/C26H31NO5/c1-7-14-31-24(30)18-8-13-22(28)21(15-18)27-23(29)16-32-20-11-9-19(10-12-20)26(5,6)17-25(2,3)4/h1,8-13,15,28H,14,16-17H2,2-6H3,(H,27,29) DAQJYTKXJDLEKN-UHFFFAOYSA-N 50250223 CHEMBL4096306::US12630497, Compound 3-17 Malate dehydrogenase, mitochondrial Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250223 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250223&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137655939 401961961 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453790 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)NC23CC4CC(CC(O)(C4)C2)C3)cc1 InChI=1S/C26H39NO3/c1-23(2,3)16-24(4,5)20-6-8-21(9-7-20)30-15-22(28)27-25-11-18-10-19(12-25)14-26(29,13-18)17-25/h6-9,18-19,29H,10-17H2,1-5H3,(H,27,28) UAKHPZUEZWZAAA-UHFFFAOYSA-N 50250222 CHEMBL4069043::US12630497, Compound 3-18 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250222 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250222&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135325046 401961960 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453791 CC(C)(C)CC(C)(C)c1ccc(OCC(=O)NC23CC4CC(CC(O)(C4)C2)C3)cc1 InChI=1S/C26H39NO3/c1-23(2,3)16-24(4,5)20-6-8-21(9-7-20)30-15-22(28)27-25-11-18-10-19(12-25)14-26(29,13-18)17-25/h6-9,18-19,29H,10-17H2,1-5H3,(H,27,28) UAKHPZUEZWZAAA-UHFFFAOYSA-N 50250222 CHEMBL4069043::US12630497, Compound 3-18 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250222 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250222&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135325046 401961960 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453792 COC(=O)c1cccc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C26H29NO4/c1-30-25(29)20-3-2-4-22(12-20)27-24(28)16-31-23-7-5-21(6-8-23)26-13-17-9-18(14-26)11-19(10-17)15-26/h2-8,12,17-19H,9-11,13-16H2,1H3,(H,27,28) WOELYKNPIBVROK-UHFFFAOYSA-N 50206600 3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-benzoic acid methyl ester::CHEMBL373396::US12630497, Compound 3-19 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206600&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 3906683 104084599 CHEMBL373396 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453793 COC(=O)c1cccc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C26H29NO4/c1-30-25(29)20-3-2-4-22(12-20)27-24(28)16-31-23-7-5-21(6-8-23)26-13-17-9-18(14-26)11-19(10-17)15-26/h2-8,12,17-19H,9-11,13-16H2,1H3,(H,27,28) WOELYKNPIBVROK-UHFFFAOYSA-N 50206600 3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-benzoic acid methyl ester::CHEMBL373396::US12630497, Compound 3-19 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206600&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 3906683 104084599 CHEMBL373396 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453794 COC(=O)c1ccc(O)c(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29) BJRPPNOJYFZSLY-UHFFFAOYSA-N 50400094 CHEMBL427092::US12630497, Compound 3-20 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400094&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 16124726 163349118 CHEMBL427092 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453795 COC(=O)c1ccc(O)c(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29) BJRPPNOJYFZSLY-UHFFFAOYSA-N 50400094 CHEMBL427092::US12630497, Compound 3-20 Malate dehydrogenase, mitochondrial Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400094&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 16124726 163349118 CHEMBL427092 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453796 CCOC(=O)COc1ccc(C(=O)OC)cc1NC(=O)COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1 InChI=1S/C30H35NO7/c1-3-36-28(33)18-38-26-9-4-22(29(34)35-2)13-25(26)31-27(32)17-37-24-7-5-23(6-8-24)30-14-19-10-20(15-30)12-21(11-19)16-30/h4-9,13,19-21H,3,10-12,14-18H2,1-2H3,(H,31,32) MRQKQHKWNVAXQN-UHFFFAOYSA-N 808064 Methyl 3-(2-(4-adamantan-1-yl-phenoxy)acetamido)-4-(2-ethoxy-2-oxoethoxy)benzoate::US12630497, Compound 3-21 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808064&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425314 533110498 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453797 CCOC(=O)COc1ccc(C(=O)OC)cc1NC(=O)COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1 InChI=1S/C30H35NO7/c1-3-36-28(33)18-38-26-9-4-22(29(34)35-2)13-25(26)31-27(32)17-37-24-7-5-23(6-8-24)30-14-19-10-20(15-30)12-21(11-19)16-30/h4-9,13,19-21H,3,10-12,14-18H2,1-2H3,(H,31,32) MRQKQHKWNVAXQN-UHFFFAOYSA-N 808064 Methyl 3-(2-(4-adamantan-1-yl-phenoxy)acetamido)-4-(2-ethoxy-2-oxoethoxy)benzoate::US12630497, Compound 3-21 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808064&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425314 533110498 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453798 COC(=O)c1ccc(OCCN2CCCC2)c(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C32H40N2O5/c1-37-31(36)25-4-9-29(38-13-12-34-10-2-3-11-34)28(17-25)33-30(35)21-39-27-7-5-26(6-8-27)32-18-22-14-23(19-32)16-24(15-22)20-32/h4-9,17,22-24H,2-3,10-16,18-21H2,1H3,(H,33,35) QXDJBZNNCHQJQN-UHFFFAOYSA-N 50250232 CHEMBL4079103::US12630497, Compound 3-22 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250232 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250232&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137649405 401961967 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453799 COC(=O)c1ccc(OCCN2CCCC2)c(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C32H40N2O5/c1-37-31(36)25-4-9-29(38-13-12-34-10-2-3-11-34)28(17-25)33-30(35)21-39-27-7-5-26(6-8-27)32-18-22-14-23(19-32)16-24(15-22)20-32/h4-9,17,22-24H,2-3,10-16,18-21H2,1H3,(H,33,35) QXDJBZNNCHQJQN-UHFFFAOYSA-N 50250232 CHEMBL4079103::US12630497, Compound 3-22 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250232 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250232&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137649405 401961967 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453800 COC(=O)c1ccc(OCCCN2CCOCC2)c(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C33H42N2O6/c1-38-32(37)26-3-8-30(40-12-2-9-35-10-13-39-14-11-35)29(18-26)34-31(36)22-41-28-6-4-27(5-7-28)33-19-23-15-24(20-33)17-25(16-23)21-33/h3-8,18,23-25H,2,9-17,19-22H2,1H3,(H,34,36) SUWQBHNNQMVQBM-UHFFFAOYSA-N 50250247 CHEMBL4103353::US12630497, Compound 3-23 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250247&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137658382 401961980 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453801 COC(=O)c1ccc(OCCCN2CCOCC2)c(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C33H42N2O6/c1-38-32(37)26-3-8-30(40-12-2-9-35-10-13-39-14-11-35)29(18-26)34-31(36)22-41-28-6-4-27(5-7-28)33-19-23-15-24(20-33)17-25(16-23)21-33/h3-8,18,23-25H,2,9-17,19-22H2,1H3,(H,34,36) SUWQBHNNQMVQBM-UHFFFAOYSA-N 50250247 CHEMBL4103353::US12630497, Compound 3-23 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250247&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137658382 401961980 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453802 COC(=O)c1ccc(OC)c(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C25H33NO5/c1-24(2,3)16-25(4,5)18-9-11-19(12-10-18)31-15-22(27)26-20-14-17(23(28)30-7)8-13-21(20)29-6/h8-14H,15-16H2,1-7H3,(H,26,27) MHYUTDIUXARMRO-UHFFFAOYSA-N 50250231 CHEMBL4068233::US12630497, Compound 3-24 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250231 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250231&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137633077 401961966 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453803 COC(=O)c1ccc(OC)c(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C25H33NO5/c1-24(2,3)16-25(4,5)18-9-11-19(12-10-18)31-15-22(27)26-20-14-17(23(28)30-7)8-13-21(20)29-6/h8-14H,15-16H2,1-7H3,(H,26,27) MHYUTDIUXARMRO-UHFFFAOYSA-N 50250231 CHEMBL4068233::US12630497, Compound 3-24 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250231 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250231&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137633077 401961966 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453804 COCCOc1ccc(cc1NC(=O)COc1ccc(cc1)C(C)(C)CC(C)(C)C)C(=O)OC InChI=1S/C27H37NO6/c1-26(2,3)18-27(4,5)20-9-11-21(12-10-20)34-17-24(29)28-22-16-19(25(30)32-7)8-13-23(22)33-15-14-31-6/h8-13,16H,14-15,17-18H2,1-7H3,(H,28,29) NZDYBPFEUARSQN-UHFFFAOYSA-N 50250217 CHEMBL4095604::US12630497, Compound 3-25 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250217&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137655014 401961955 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453805 COCCOc1ccc(cc1NC(=O)COc1ccc(cc1)C(C)(C)CC(C)(C)C)C(=O)OC InChI=1S/C27H37NO6/c1-26(2,3)18-27(4,5)20-9-11-21(12-10-20)34-17-24(29)28-22-16-19(25(30)32-7)8-13-23(22)33-15-14-31-6/h8-13,16H,14-15,17-18H2,1-7H3,(H,28,29) NZDYBPFEUARSQN-UHFFFAOYSA-N 50250217 CHEMBL4095604::US12630497, Compound 3-25 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250217&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137655014 401961955 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453806 COC(=O)c1ccc(OCCN2CCOCC2)c(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C30H42N2O6/c1-29(2,3)21-30(4,5)23-8-10-24(11-9-23)38-20-27(33)31-25-19-22(28(34)35-6)7-12-26(25)37-18-15-32-13-16-36-17-14-32/h7-12,19H,13-18,20-21H2,1-6H3,(H,31,33) FJFDLLGXWZXSGF-UHFFFAOYSA-N 50250246 CHEMBL4059591::US12630497, Compound 3-26 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250246&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135325018 401961979 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453807 COC(=O)c1ccc(OCCN2CCOCC2)c(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C30H42N2O6/c1-29(2,3)21-30(4,5)23-8-10-24(11-9-23)38-20-27(33)31-25-19-22(28(34)35-6)7-12-26(25)37-18-15-32-13-16-36-17-14-32/h7-12,19H,13-18,20-21H2,1-6H3,(H,31,33) FJFDLLGXWZXSGF-UHFFFAOYSA-N 50250246 CHEMBL4059591::US12630497, Compound 3-26 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250246&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135325018 401961979 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453808 COC(=O)c1ccc(OCC#C)c(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C27H33NO5/c1-8-15-32-23-14-9-19(25(30)31-7)16-22(23)28-24(29)17-33-21-12-10-20(11-13-21)27(5,6)18-26(2,3)4/h1,9-14,16H,15,17-18H2,2-7H3,(H,28,29) YJDWUKWPEJYHKU-UHFFFAOYSA-N 50250230 CHEMBL4087903::US12630497, Compound 3-27 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250230 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250230&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135325047 401961965 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453809 COC(=O)c1ccc(OCC#C)c(NC(=O)COc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C27H33NO5/c1-8-15-32-23-14-9-19(25(30)31-7)16-22(23)28-24(29)17-33-21-12-10-20(11-13-21)27(5,6)18-26(2,3)4/h1,9-14,16H,15,17-18H2,2-7H3,(H,28,29) YJDWUKWPEJYHKU-UHFFFAOYSA-N 50250230 CHEMBL4087903::US12630497, Compound 3-27 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250230 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250230&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135325047 401961965 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453810 COC(=O)c1ccc(OCc2ccc(OC)cc2)c(NC(=O)COc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C32H39NO6/c1-31(2,3)21-32(4,5)24-11-15-26(16-12-24)38-20-29(34)33-27-18-23(30(35)37-7)10-17-28(27)39-19-22-8-13-25(36-6)14-9-22/h8-18H,19-21H2,1-7H3,(H,33,34) XNLFCUQQCHRELL-UHFFFAOYSA-N 808071 Methyl 4-(4-methoxybenzyloxy)-3-(2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acetamido)benzoate::US12630497, Compound 3-28 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808071&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135325139 533110505 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453811 COC(=O)c1ccc(OCc2ccc(OC)cc2)c(NC(=O)COc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C32H39NO6/c1-31(2,3)21-32(4,5)24-11-15-26(16-12-24)38-20-29(34)33-27-18-23(30(35)37-7)10-17-28(27)39-19-22-8-13-25(36-6)14-9-22/h8-18H,19-21H2,1-7H3,(H,33,34) XNLFCUQQCHRELL-UHFFFAOYSA-N 808071 Methyl 4-(4-methoxybenzyloxy)-3-(2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acetamido)benzoate::US12630497, Compound 3-28 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808071&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135325139 533110505 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453812 COC(=O)c1cccc(NC(=O)C(C)(C)Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C28H33NO4/c1-27(2,26(31)29-23-6-4-5-21(14-23)25(30)32-3)33-24-9-7-22(8-10-24)28-15-18-11-19(16-28)13-20(12-18)17-28/h4-10,14,18-20H,11-13,15-17H2,1-3H3,(H,29,31) POBQPFVELWZREF-UHFFFAOYSA-N 50250220 CHEMBL4098767::US12630497, Compound 3-29 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250220&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135324915 401961958 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453813 COC(=O)c1cccc(NC(=O)C(C)(C)Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C28H33NO4/c1-27(2,26(31)29-23-6-4-5-21(14-23)25(30)32-3)33-24-9-7-22(8-10-24)28-15-18-11-19(16-28)13-20(12-18)17-28/h4-10,14,18-20H,11-13,15-17H2,1-3H3,(H,29,31) POBQPFVELWZREF-UHFFFAOYSA-N 50250220 CHEMBL4098767::US12630497, Compound 3-29 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250220&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135324915 401961958 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453814 COC(=O)c1cccc(NC(=O)C(C)(C)Oc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C26H35NO4/c1-24(2,3)17-25(4,5)19-12-14-21(15-13-19)31-26(6,7)23(29)27-20-11-9-10-18(16-20)22(28)30-8/h9-16H,17H2,1-8H3,(H,27,29) IQJDMXNNVQULIS-UHFFFAOYSA-N 50250243 CHEMBL4074947::US12630497, Compound 3-30 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250243&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135325057 401961976 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453815 COC(=O)c1cccc(NC(=O)C(C)(C)Oc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C26H35NO4/c1-24(2,3)17-25(4,5)19-12-14-21(15-13-19)31-26(6,7)23(29)27-20-11-9-10-18(16-20)22(28)30-8/h9-16H,17H2,1-8H3,(H,27,29) IQJDMXNNVQULIS-UHFFFAOYSA-N 50250243 CHEMBL4074947::US12630497, Compound 3-30 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250243&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135325057 401961976 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453816 COC(=O)c1ccc(O)c(NC(=O)C(C)(C)Oc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C26H35NO5/c1-24(2,3)16-25(4,5)18-10-12-19(13-11-18)32-26(6,7)23(30)27-20-15-17(22(29)31-8)9-14-21(20)28/h9-15,28H,16H2,1-8H3,(H,27,30) XNTBPVTVUJMUPY-UHFFFAOYSA-N 50250219 CHEMBL4095380::US12630497, Compound 3-31 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250219&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137653816 401961957 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453817 COC(=O)c1ccc(O)c(NC(=O)C(C)(C)Oc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C26H35NO5/c1-24(2,3)16-25(4,5)18-10-12-19(13-11-18)32-26(6,7)23(30)27-20-15-17(22(29)31-8)9-14-21(20)28/h9-15,28H,16H2,1-8H3,(H,27,30) XNTBPVTVUJMUPY-UHFFFAOYSA-N 50250219 CHEMBL4095380::US12630497, Compound 3-31 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250219&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137653816 401961957 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453818 COC(=O)c1cccc(NC(=O)CCCOc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C28H33NO4/c1-32-27(31)22-4-2-5-24(15-22)29-26(30)6-3-11-33-25-9-7-23(8-10-25)28-16-19-12-20(17-28)14-21(13-19)18-28/h2,4-5,7-10,15,19-21H,3,6,11-14,16-18H2,1H3,(H,29,30) NJOQJRZPBIEPOU-UHFFFAOYSA-N 50400096 CHEMBL2178406::US12630497, Compound 3-32 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400096&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 71459048 163349120 CHEMBL2178406 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453819 COC(=O)c1cccc(NC(=O)CCCOc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C28H33NO4/c1-32-27(31)22-4-2-5-24(15-22)29-26(30)6-3-11-33-25-9-7-23(8-10-25)28-16-19-12-20(17-28)14-21(13-19)18-28/h2,4-5,7-10,15,19-21H,3,6,11-14,16-18H2,1H3,(H,29,30) NJOQJRZPBIEPOU-UHFFFAOYSA-N 50400096 CHEMBL2178406::US12630497, Compound 3-32 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400096&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 71459048 163349120 CHEMBL2178406 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453820 COC(=O)c1cccc(NC(=O)CCCOc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C26H35NO4/c1-25(2,3)18-26(4,5)20-12-14-22(15-13-20)31-16-8-11-23(28)27-21-10-7-9-19(17-21)24(29)30-6/h7,9-10,12-15,17H,8,11,16,18H2,1-6H3,(H,27,28) RJDGJBQHQLDKNJ-UHFFFAOYSA-N 50250244 CHEMBL4091027::US12630497, Compound 3-33 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250244&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 135324866 401961977 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453821 COC(=O)c1cccc(NC(=O)CCCOc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C26H35NO4/c1-25(2,3)18-26(4,5)20-12-14-22(15-13-20)31-16-8-11-23(28)27-21-10-7-9-19(17-21)24(29)30-6/h7,9-10,12-15,17H,8,11,16,18H2,1-6H3,(H,27,28) RJDGJBQHQLDKNJ-UHFFFAOYSA-N 50250244 CHEMBL4091027::US12630497, Compound 3-33 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250244&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 135324866 401961977 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453822 COC(=O)c1ccc(O)c(NC(=O)CCCOc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C26H35NO5/c1-25(2,3)17-26(4,5)19-10-12-20(13-11-19)32-15-7-8-23(29)27-21-16-18(24(30)31-6)9-14-22(21)28/h9-14,16,28H,7-8,15,17H2,1-6H3,(H,27,29) QMCXVSNQCUTLQV-UHFFFAOYSA-N 50250221 CHEMBL4080721::US12630497, Compound 3-34 Malate dehydrogenase, cytoplasmic Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250221 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250221&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137647839 401961959 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453823 COC(=O)c1ccc(O)c(NC(=O)CCCOc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C26H35NO5/c1-25(2,3)17-26(4,5)19-10-12-20(13-11-19)32-15-7-8-23(29)27-21-16-18(24(30)31-6)9-14-22(21)28/h9-14,16,28H,7-8,15,17H2,1-6H3,(H,27,29) QMCXVSNQCUTLQV-UHFFFAOYSA-N 50250221 CHEMBL4080721::US12630497, Compound 3-34 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250221 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250221&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137647839 401961959 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453824 COC(=O)c1cccc(NC(=O)/C=C/Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C27H29NO4/c1-31-26(30)21-3-2-4-23(14-21)28-25(29)9-10-32-24-7-5-22(6-8-24)27-15-18-11-19(16-27)13-20(12-18)17-27/h2-10,14,18-20H,11-13,15-17H2,1H3,(H,28,29) LPLIRUZJZGGXSY-UHFFFAOYSA-N 50400095 CHEMBL2178407::US12630497, Compound 6-1 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400095&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 56967243 163349119 CHEMBL2178407 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453825 COC(=O)c1cccc(NC(=O)/C=C/Oc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C27H29NO4/c1-31-26(30)21-3-2-4-23(14-21)28-25(29)9-10-32-24-7-5-22(6-8-24)27-15-18-11-19(16-27)13-20(12-18)17-27/h2-10,14,18-20H,11-13,15-17H2,1H3,(H,28,29) LPLIRUZJZGGXSY-UHFFFAOYSA-N 50400095 CHEMBL2178407::US12630497, Compound 6-1 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400095&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 56967243 163349119 CHEMBL2178407 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453826 COC(=O)c1cccc(NC(=O)\C=C\Oc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C25H31NO4/c1-24(2,3)17-25(4,5)19-10-12-21(13-11-19)30-15-14-22(27)26-20-9-7-8-18(16-20)23(28)29-6/h7-16H,17H2,1-6H3,(H,26,27) ZEXAUCGQGNXJFD-UHFFFAOYSA-N 50400092 CHEMBL2178409::US12630497, Compound 6-2 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400092&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 56967304 163349116 CHEMBL2178409 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453827 COC(=O)c1cccc(NC(=O)\C=C\Oc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C25H31NO4/c1-24(2,3)17-25(4,5)19-10-12-21(13-11-19)30-15-14-22(27)26-20-9-7-8-18(16-20)23(28)29-6/h7-16H,17H2,1-6H3,(H,26,27) ZEXAUCGQGNXJFD-UHFFFAOYSA-N 50400092 CHEMBL2178409::US12630497, Compound 6-2 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400092&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 56967304 163349116 CHEMBL2178409 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453828 COC(=O)c1ccc(C)c(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C26H33NO4/c1-18-8-9-19(24(29)30-7)16-22(18)27-23(28)14-15-31-21-12-10-20(11-13-21)26(5,6)17-25(2,3)4/h8-16H,17H2,1-7H3,(H,27,28) KWYXNSBMKPZOES-UHFFFAOYSA-N 808080 (E)-methyl 4-methyl-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-3 Malate dehydrogenase, cytoplasmic Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808080&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425303 533110514 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453829 COC(=O)c1ccc(C)c(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C26H33NO4/c1-18-8-9-19(24(29)30-7)16-22(18)27-23(28)14-15-31-21-12-10-20(11-13-21)26(5,6)17-25(2,3)4/h8-16H,17H2,1-7H3,(H,27,28) KWYXNSBMKPZOES-UHFFFAOYSA-N 808080 (E)-methyl 4-methyl-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-3 Malate dehydrogenase, mitochondrial Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808080&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425303 533110514 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453830 COC(=O)c1cc(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)ccc1C InChI=1S/C26H33NO4/c1-18-8-11-20(16-22(18)24(29)30-7)27-23(28)14-15-31-21-12-9-19(10-13-21)26(5,6)17-25(2,3)4/h8-16H,17H2,1-7H3,(H,27,28) XVNCAPHZKGVSEB-UHFFFAOYSA-N 808081 (E)-methyl 2-methyl-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-4 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808081&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425319 533110515 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453831 COC(=O)c1cc(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)ccc1C InChI=1S/C26H33NO4/c1-18-8-11-20(16-22(18)24(29)30-7)27-23(28)14-15-31-21-12-9-19(10-13-21)26(5,6)17-25(2,3)4/h8-16H,17H2,1-7H3,(H,27,28) XVNCAPHZKGVSEB-UHFFFAOYSA-N 808081 (E)-methyl 2-methyl-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-4 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808081&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425319 533110515 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453832 COC(=O)c1cc(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)ccc1O InChI=1S/C25H31NO5/c1-24(2,3)16-25(4,5)17-7-10-19(11-8-17)31-14-13-22(28)26-18-9-12-21(27)20(15-18)23(29)30-6/h7-15,27H,16H2,1-6H3,(H,26,28) LYXRVAJLRWFNTM-UHFFFAOYSA-N 808082 (E)-methyl 2-hydroxy-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-5 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808082&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425308 533110516 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453833 COC(=O)c1cc(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)ccc1O InChI=1S/C25H31NO5/c1-24(2,3)16-25(4,5)17-7-10-19(11-8-17)31-14-13-22(28)26-18-9-12-21(27)20(15-18)23(29)30-6/h7-15,27H,16H2,1-6H3,(H,26,28) LYXRVAJLRWFNTM-UHFFFAOYSA-N 808082 (E)-methyl 2-hydroxy-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-5 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808082&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425308 533110516 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453834 CC(C)OC(=O)c1cccc(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C27H35NO4/c1-19(2)32-25(30)20-9-8-10-22(17-20)28-24(29)15-16-31-23-13-11-21(12-14-23)27(6,7)18-26(3,4)5/h8-17,19H,18H2,1-7H3,(H,28,29) SZLGYYCKPQKEDS-UHFFFAOYSA-N 808083 (E)-isopropyl 3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-6 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808083&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425315 533110517 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453835 CC(C)OC(=O)c1cccc(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C27H35NO4/c1-19(2)32-25(30)20-9-8-10-22(17-20)28-24(29)15-16-31-23-13-11-21(12-14-23)27(6,7)18-26(3,4)5/h8-17,19H,18H2,1-7H3,(H,28,29) SZLGYYCKPQKEDS-UHFFFAOYSA-N 808083 (E)-isopropyl 3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-6 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808083&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425315 533110517 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453836 COC(=O)c1cc(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)c(C)cc1C InChI=1S/C27H35NO4/c1-18-15-19(2)23(16-22(18)25(30)31-8)28-24(29)13-14-32-21-11-9-20(10-12-21)27(6,7)17-26(3,4)5/h9-16H,17H2,1-8H3,(H,28,29) KDUKDLSCMUODHQ-UHFFFAOYSA-N 808084 (E)-methyl 2,4-dimethyl-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-7 Malate dehydrogenase, cytoplasmic Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808084&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425311 533110518 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453837 COC(=O)c1cc(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)c(C)cc1C InChI=1S/C27H35NO4/c1-18-15-19(2)23(16-22(18)25(30)31-8)28-24(29)13-14-32-21-11-9-20(10-12-21)27(6,7)17-26(3,4)5/h9-16H,17H2,1-8H3,(H,28,29) KDUKDLSCMUODHQ-UHFFFAOYSA-N 808084 (E)-methyl 2,4-dimethyl-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-7 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808084&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425311 533110518 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453838 CC(C)(C)CC(C)(C)c1ccc(O/C=C/C(=O)On2nnc3cccnc32)cc1 InChI=1S/C22H26N4O3/c1-21(2,3)15-22(4,5)16-8-10-17(11-9-16)28-14-12-19(27)29-26-20-18(24-25-26)7-6-13-23-20/h6-14H,15H2,1-5H3 ICSJREQUSOUULO-UHFFFAOYSA-N 808085 (E)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl 3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylate::US12630497, Compound 6-8 Malate dehydrogenase, cytoplasmic Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808085&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425305 533110519 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453839 CC(C)(C)CC(C)(C)c1ccc(O/C=C/C(=O)On2nnc3cccnc32)cc1 InChI=1S/C22H26N4O3/c1-21(2,3)15-22(4,5)16-8-10-17(11-9-16)28-14-12-19(27)29-26-20-18(24-25-26)7-6-13-23-20/h6-14H,15H2,1-5H3 ICSJREQUSOUULO-UHFFFAOYSA-N 808085 (E)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl 3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylate::US12630497, Compound 6-8 Malate dehydrogenase, mitochondrial Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808085&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425305 533110519 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453840 CC(C)(C)CC(C)(C)c1ccc(O/C=C/C(=O)On2nnc3ccccc32)cc1 InChI=1S/C23H27N3O3/c1-22(2,3)16-23(4,5)17-10-12-18(13-11-17)28-15-14-21(27)29-26-20-9-7-6-8-19(20)24-25-26/h6-15H,16H2,1-5H3 DBKCUHGLJSWOCV-UHFFFAOYSA-N 808086 (E)-1H-benzo[d][1,2,3]triazol-1-yl 3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylate::US12630497, Compound 6-9 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808086&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425306 533110520 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453841 CC(C)(C)CC(C)(C)c1ccc(O/C=C/C(=O)On2nnc3ccccc32)cc1 InChI=1S/C23H27N3O3/c1-22(2,3)16-23(4,5)17-10-12-18(13-11-17)28-15-14-21(27)29-26-20-9-7-6-8-19(20)24-25-26/h6-15H,16H2,1-5H3 DBKCUHGLJSWOCV-UHFFFAOYSA-N 808086 (E)-1H-benzo[d][1,2,3]triazol-1-yl 3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylate::US12630497, Compound 6-9 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808086&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425306 533110520 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453842 COC(=O)c1ccc(O)c(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C25H31NO5/c1-24(2,3)16-25(4,5)18-8-10-19(11-9-18)31-14-13-22(28)26-20-15-17(23(29)30-6)7-12-21(20)27/h7-15,27H,16H2,1-6H3,(H,26,28) ZAIJUSUOQQNSKE-UHFFFAOYSA-N 808087 (E)-methyl 4-hydroxy-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-10 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808087&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425320 533110521 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453843 COC(=O)c1ccc(O)c(NC(=O)/C=C/Oc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C25H31NO5/c1-24(2,3)16-25(4,5)18-8-10-19(11-9-18)31-14-13-22(28)26-20-15-17(23(29)30-6)7-12-21(20)27/h7-15,27H,16H2,1-6H3,(H,26,28) ZAIJUSUOQQNSKE-UHFFFAOYSA-N 808087 (E)-methyl 4-hydroxy-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acrylamido)benzoate::US12630497, Compound 6-10 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808087&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425320 533110521 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453844 COC(=O)c1cccc(NC(=O)CCOc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C27H31NO4/c1-31-26(30)21-3-2-4-23(14-21)28-25(29)9-10-32-24-7-5-22(6-8-24)27-15-18-11-19(16-27)13-20(12-18)17-27/h2-8,14,18-20H,9-13,15-17H2,1H3,(H,28,29) DCWZGVZXOAEXSK-UHFFFAOYSA-N 50400097 CHEMBL2177118::US12630497, Compound 9-1 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400097&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 71453683 163349121 CHEMBL2177118 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453845 COC(=O)c1cccc(NC(=O)CCOc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1 InChI=1S/C27H31NO4/c1-31-26(30)21-3-2-4-23(14-21)28-25(29)9-10-32-24-7-5-22(6-8-24)27-15-18-11-19(16-27)13-20(12-18)17-27/h2-8,14,18-20H,9-13,15-17H2,1H3,(H,28,29) DCWZGVZXOAEXSK-UHFFFAOYSA-N 50400097 CHEMBL2177118::US12630497, Compound 9-1 Malate dehydrogenase, mitochondrial Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400097&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 71453683 163349121 CHEMBL2177118 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453846 COC(=O)c1cccc(NC(=O)CCOc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C25H33NO4/c1-24(2,3)17-25(4,5)19-10-12-21(13-11-19)30-15-14-22(27)26-20-9-7-8-18(16-20)23(28)29-6/h7-13,16H,14-15,17H2,1-6H3,(H,26,27) FLLJXWXMLLAKKZ-UHFFFAOYSA-N 50250242 CHEMBL4068781::US12630497, Compound 9-2 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250242&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137633479 401961975 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453847 COC(=O)c1cccc(NC(=O)CCOc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C25H33NO4/c1-24(2,3)17-25(4,5)19-10-12-21(13-11-19)30-15-14-22(27)26-20-9-7-8-18(16-20)23(28)29-6/h7-13,16H,14-15,17H2,1-6H3,(H,26,27) FLLJXWXMLLAKKZ-UHFFFAOYSA-N 50250242 CHEMBL4068781::US12630497, Compound 9-2 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250242&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137633479 401961975 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453848 COC(=O)c1ccc(O)c(NC(=O)CCOc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C25H33NO5/c1-24(2,3)16-25(4,5)18-8-10-19(11-9-18)31-14-13-22(28)26-20-15-17(23(29)30-6)7-12-21(20)27/h7-12,15,27H,13-14,16H2,1-6H3,(H,26,28) MSPMVYHVOKSJJP-UHFFFAOYSA-N 50250218 CHEMBL4074694::US12630497, Compound 9-3 Malate dehydrogenase, cytoplasmic Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250218 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250218&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 137650633 401961956 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453849 COC(=O)c1ccc(O)c(NC(=O)CCOc2ccc(cc2)C(C)(C)CC(C)(C)C)c1 InChI=1S/C25H33NO5/c1-24(2,3)16-25(4,5)18-8-10-19(11-9-18)31-14-13-22(28)26-20-15-17(23(29)30-6)7-12-21(20)27/h7-12,15,27H,13-14,16H2,1-6H3,(H,26,28) MSPMVYHVOKSJJP-UHFFFAOYSA-N 50250218 CHEMBL4074694::US12630497, Compound 9-3 Malate dehydrogenase, mitochondrial Homo sapiens 3000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250218 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250218&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 137650633 401961956 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453850 COC(=O)c1ccc(C)c(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C26H35NO4/c1-18-8-9-19(24(29)30-7)16-22(18)27-23(28)14-15-31-21-12-10-20(11-13-21)26(5,6)17-25(2,3)4/h8-13,16H,14-15,17H2,1-7H3,(H,27,28) DNYZLYZZIUQZSL-UHFFFAOYSA-N 808091 Methyl 4-methyl-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzoate::US12630497, Compound 9-4 Malate dehydrogenase, cytoplasmic Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808091&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425313 533110525 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453851 COC(=O)c1ccc(C)c(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C26H35NO4/c1-18-8-9-19(24(29)30-7)16-22(18)27-23(28)14-15-31-21-12-10-20(11-13-21)26(5,6)17-25(2,3)4/h8-13,16H,14-15,17H2,1-7H3,(H,27,28) DNYZLYZZIUQZSL-UHFFFAOYSA-N 808091 Methyl 4-methyl-3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzoate::US12630497, Compound 9-4 Malate dehydrogenase, mitochondrial Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808091&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425313 533110525 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453852 COC(=O)c1cc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)ccc1C InChI=1S/C26H35NO4/c1-18-8-11-20(16-22(18)24(29)30-7)27-23(28)14-15-31-21-12-9-19(10-13-21)26(5,6)17-25(2,3)4/h8-13,16H,14-15,17H2,1-7H3,(H,27,28) OLIPDGRECXMHAI-UHFFFAOYSA-N 808092 Methyl 2-methyl-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzoate::US12630497, Compound 9-5 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808092&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425321 533110526 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453853 COC(=O)c1cc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)ccc1C InChI=1S/C26H35NO4/c1-18-8-11-20(16-22(18)24(29)30-7)27-23(28)14-15-31-21-12-9-19(10-13-21)26(5,6)17-25(2,3)4/h8-13,16H,14-15,17H2,1-7H3,(H,27,28) OLIPDGRECXMHAI-UHFFFAOYSA-N 808092 Methyl 2-methyl-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzoate::US12630497, Compound 9-5 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808092&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425321 533110526 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453854 COC(=O)c1cc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)ccc1O InChI=1S/C25H33NO5/c1-24(2,3)16-25(4,5)17-7-10-19(11-8-17)31-14-13-22(28)26-18-9-12-21(27)20(15-18)23(29)30-6/h7-12,15,27H,13-14,16H2,1-6H3,(H,26,28) SOSOAVTZWQZLOT-UHFFFAOYSA-N 808093 Methyl 2-hydroxy-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzoate::US12630497, Compound 9-6 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808093&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425330 533110527 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453855 COC(=O)c1cc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)ccc1O InChI=1S/C25H33NO5/c1-24(2,3)16-25(4,5)17-7-10-19(11-8-17)31-14-13-22(28)26-18-9-12-21(27)20(15-18)23(29)30-6/h7-12,15,27H,13-14,16H2,1-6H3,(H,26,28) SOSOAVTZWQZLOT-UHFFFAOYSA-N 808093 Methyl 2-hydroxy-5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzoate::US12630497, Compound 9-6 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808093&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425330 533110527 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453856 CC(C)OC(=O)c1cccc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C27H37NO4/c1-19(2)32-25(30)20-9-8-10-22(17-20)28-24(29)15-16-31-23-13-11-21(12-14-23)27(6,7)18-26(3,4)5/h8-14,17,19H,15-16,18H2,1-7H3,(H,28,29) XLHMZLWENSDQIH-UHFFFAOYSA-N 808094 Isopropyl 3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzoate::US12630497, Compound 9-7 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808094&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425307 533110528 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453857 CC(C)OC(=O)c1cccc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C27H37NO4/c1-19(2)32-25(30)20-9-8-10-22(17-20)28-24(29)15-16-31-23-13-11-21(12-14-23)27(6,7)18-26(3,4)5/h8-14,17,19H,15-16,18H2,1-7H3,(H,28,29) XLHMZLWENSDQIH-UHFFFAOYSA-N 808094 Isopropyl 3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzoate::US12630497, Compound 9-7 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808094&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425307 533110528 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453858 COC(=O)c1cncc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C24H32N2O4/c1-23(2,3)16-24(4,5)18-7-9-20(10-8-18)30-12-11-21(27)26-19-13-17(14-25-15-19)22(28)29-6/h7-10,13-15H,11-12,16H2,1-6H3,(H,26,27) MGBVHDCYXYECJV-UHFFFAOYSA-N 808095 Methyl 5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)nicotinate::US12630497, Compound 9-8 Malate dehydrogenase, cytoplasmic Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808095&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425324 533110529 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453859 COC(=O)c1cncc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C24H32N2O4/c1-23(2,3)16-24(4,5)18-7-9-20(10-8-18)30-12-11-21(27)26-19-13-17(14-25-15-19)22(28)29-6/h7-10,13-15H,11-12,16H2,1-6H3,(H,26,27) MGBVHDCYXYECJV-UHFFFAOYSA-N 808095 Methyl 5-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)nicotinate::US12630497, Compound 9-8 Malate dehydrogenase, mitochondrial Homo sapiens 7500 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808095&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425324 533110529 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453860 CC(C)(C)CC(C)(C)c1ccc(OCCC(=O)Nc2cccc(C(=O)N3CCOCC3)c2)cc1 InChI=1S/C28H38N2O4/c1-27(2,3)20-28(4,5)22-9-11-24(12-10-22)34-16-13-25(31)29-23-8-6-7-21(19-23)26(32)30-14-17-33-18-15-30/h6-12,19H,13-18,20H2,1-5H3,(H,29,31) LPJNSYPLMJBCTA-UHFFFAOYSA-N 808096 N-(3-(morpholine-4-carbonyl)phenyl)-3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamide::US12630497, Compound 9-9 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808096&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425301 533110530 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453861 CC(C)(C)CC(C)(C)c1ccc(OCCC(=O)Nc2cccc(C(=O)N3CCOCC3)c2)cc1 InChI=1S/C28H38N2O4/c1-27(2,3)20-28(4,5)22-9-11-24(12-10-22)34-16-13-25(31)29-23-8-6-7-21(19-23)26(32)30-14-17-33-18-15-30/h6-12,19H,13-18,20H2,1-5H3,(H,29,31) LPJNSYPLMJBCTA-UHFFFAOYSA-N 808096 N-(3-(morpholine-4-carbonyl)phenyl)-3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamide::US12630497, Compound 9-9 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808096&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425301 533110530 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453862 CCOC(=O)CNC(=O)c1cccc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C28H38N2O5/c1-7-34-25(32)18-29-26(33)20-9-8-10-22(17-20)30-24(31)15-16-35-23-13-11-21(12-14-23)28(5,6)19-27(2,3)4/h8-14,17H,7,15-16,18-19H2,1-6H3,(H,29,33)(H,30,31) MEYYAXJQRCFQRO-UHFFFAOYSA-N 808097 Ethyl 2-(3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzamido)acetate::US12630497, Compound 9-10 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808097&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425322 533110531 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453863 CCOC(=O)CNC(=O)c1cccc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1 InChI=1S/C28H38N2O5/c1-7-34-25(32)18-29-26(33)20-9-8-10-22(17-20)30-24(31)15-16-35-23-13-11-21(12-14-23)28(5,6)19-27(2,3)4/h8-14,17H,7,15-16,18-19H2,1-6H3,(H,29,33)(H,30,31) MEYYAXJQRCFQRO-UHFFFAOYSA-N 808097 Ethyl 2-(3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzamido)acetate::US12630497, Compound 9-10 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808097&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425322 533110531 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682 453864 COC(=O)[C@@H](NC(=O)c1cccc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1)C(C)C InChI=1S/C30H42N2O5/c1-20(2)26(28(35)36-8)32-27(34)21-10-9-11-23(18-21)31-25(33)16-17-37-24-14-12-22(13-15-24)30(6,7)19-29(3,4)5/h9-15,18,20,26H,16-17,19H2,1-8H3,(H,31,33)(H,32,34) JVIMDEPYKYHAOT-UHFFFAOYSA-N 808098 (S)-methyl 3-methyl-2-(3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzamido)butanoate::US12630497, Compound 9-11 Malate dehydrogenase, cytoplasmic Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001361&target=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808098&enzyme=Malate+dehydrogenase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 142425328 533110532 1 MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA 7RRL,7RM9 Malate dehydrogenase, cytoplasmic MDHC_HUMAN P40925 B2R5V5 B4DUN2 B7Z3I7 F5H098 Q6I9V0 453865 COC(=O)[C@@H](NC(=O)c1cccc(NC(=O)CCOc2ccc(C(C)(C)CC(C)(C)C)cc2)c1)C(C)C InChI=1S/C30H42N2O5/c1-20(2)26(28(35)36-8)32-27(34)21-10-9-11-23(18-21)31-25(33)16-17-37-24-14-12-22(13-15-24)30(6,7)19-29(3,4)5/h9-15,18,20,26H,16-17,19H2,1-8H3,(H,31,33)(H,32,34) JVIMDEPYKYHAOT-UHFFFAOYSA-N 808098 (S)-methyl 3-methyl-2-(3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propanamido)benzamido)butanoate::US12630497, Compound 9-11 Malate dehydrogenase, mitochondrial Homo sapiens >10000 US Patent 10.7270/Q20Z788T aid1803677 US12630497-B2 Lee, K; Won, MS; Ban, HS; Kim, M; Kim, BK 12/4/2018 3/30/2019 Dongguk University Industry-Academic Cooperation Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=808098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004422&target=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=808098&enzyme=Malate+dehydrogenase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 142425328 533110532 1 MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK Malate dehydrogenase, mitochondrial MDHM_HUMAN P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682