BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 626525 Cc1cccc(C(F)(F)F)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H31F4NO2/c1-21-5-2-8-29(33(35,36)37)30(21)28-7-3-6-25-18-26(32(39)40)13-14-27(25)31(28)24-11-9-22(10-12-24)17-23-19-38(20-23)16-4-15-34/h2,5,8-14,17-18H,3-4,6-7,15-16,19-20H2,1H3,(H,39,40) HJOAPCZWBLLKJE-UHFFFAOYSA-N 764347 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methyl-6- (trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 1 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764347&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239640 520665802 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626526 O=C(O)c1ccc2c(c1)CCCC(c1ccc(F)c(F)c1C(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H27F6NO2/c33-13-2-14-39-17-20(18-39)15-19-5-7-21(8-6-19)28-24-10-9-23(31(40)41)16-22(24)3-1-4-25(28)26-11-12-27(34)30(35)29(26)32(36,37)38/h5-12,15-16H,1-4,13-14,17-18H2,(H,40,41) BKIBPINSLGTUAU-UHFFFAOYSA-N 764348 8-(3,4-difluoro-2-(trifluoromethyl)phenyl)-9- (4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 2 Estrogen receptor Human 1.000 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764348 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764348&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239578 520665803 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626527 COc1c(C)cccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H34FNO3/c1-22-6-3-9-30(32(22)38-2)29-8-4-7-26-19-27(33(36)37)14-15-28(26)31(29)25-12-10-23(11-13-25)18-24-20-35(21-24)17-5-16-34/h3,6,9-15,18-19H,4-5,7-8,16-17,20-21H2,1-2H3,(H,36,37) HVAWLERAKOLNEV-UHFFFAOYSA-N 764349 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methoxy-3- methylphenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 3 Estrogen receptor Human 0.700 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764349 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764349&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239497 520665804 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626528 COc1cccc(C)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H34FNO3/c1-22-6-3-9-30(38-2)31(22)29-8-4-7-26-19-27(33(36)37)14-15-28(26)32(29)25-12-10-23(11-13-25)18-24-20-35(21-24)17-5-16-34/h3,6,9-15,18-19H,4-5,7-8,16-17,20-21H2,1-2H3,(H,36,37) DPZOLKRCFWVODA-UHFFFAOYSA-N 764350 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methoxy-6- methylphenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 4 Estrogen receptor Human 1.10 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764350 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764350&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239525 520665805 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626529 CCc1c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)cccc1C(F)(F)F InChI=1S/C34H33F4NO2/c1-2-27-29(7-4-9-31(27)34(36,37)38)30-8-3-6-25-19-26(33(40)41)14-15-28(25)32(30)24-12-10-22(11-13-24)18-23-20-39(21-23)17-5-16-35/h4,7,9-15,18-19H,2-3,5-6,8,16-17,20-21H2,1H3,(H,40,41) IWRWGKVGKSNMBW-UHFFFAOYSA-N 764351 8-(2-ethyl-3-(trifluoromethyl)phenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 5 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764351 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764351&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239566 520665806 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626530 COc1cccc(C(F)(F)F)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H31F4NO3/c1-41-29-8-3-7-28(33(35,36)37)31(29)27-6-2-5-24-18-25(32(39)40)13-14-26(24)30(27)23-11-9-21(10-12-23)17-22-19-38(20-22)16-4-15-34/h3,7-14,17-18H,2,4-6,15-16,19-20H2,1H3,(H,39,40) NDRGAYXPENIASO-UHFFFAOYSA-N 764352 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methoxy-6- (trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 6 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764352 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764352&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239618 520665807 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626531 COc1c(F)ccc(C)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H33F2NO3/c1-21-7-14-29(35)32(39-2)30(21)28-6-3-5-25-18-26(33(37)38)12-13-27(25)31(28)24-10-8-22(9-11-24)17-23-19-36(20-23)16-4-15-34/h7-14,17-18H,3-6,15-16,19-20H2,1-2H3,(H,37,38) KUDDCDVTIHIPFR-UHFFFAOYSA-N 764353 8-(3-fluoro-2-methoxy-6-methylphenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 7 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764353 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764353&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239517 520665808 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626532 CCc1cccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c1C(F)(F)F InChI=1S/C34H33F4NO2/c1-2-24-6-3-9-30(32(24)34(36,37)38)29-8-4-7-26-19-27(33(40)41)14-15-28(26)31(29)25-12-10-22(11-13-25)18-23-20-39(21-23)17-5-16-35/h3,6,9-15,18-19H,2,4-5,7-8,16-17,20-21H2,1H3,(H,40,41) CWHVEMJEKFZYDU-UHFFFAOYSA-N 764354 8-(3-ethyl-2-(trifluoromethyl)phenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 8 Estrogen receptor Human 0.800 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764354 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764354&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239518 520665809 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626533 O=C(O)c1ccc2c(c1)CCCC(c1c(F)cccc1OC(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H28F5NO3/c33-14-3-15-38-18-21(19-38)16-20-8-10-22(11-9-20)29-25-13-12-24(31(39)40)17-23(25)4-1-5-26(29)30-27(34)6-2-7-28(30)41-32(35,36)37/h2,6-13,16-17H,1,3-5,14-15,18-19H2,(H,39,40) AQACXTZCXQJIHK-UHFFFAOYSA-N 764355 8-(2-fluoro-6-(trifluoromethoxy)phenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 9 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764355 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764355&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239598 520665810 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626534 Cc1cc(C)c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C)c1 InChI=1S/C34H36FNO2/c1-22-16-23(2)32(24(3)17-22)31-7-4-6-28-19-29(34(37)38)12-13-30(28)33(31)27-10-8-25(9-11-27)18-26-20-36(21-26)15-5-14-35/h8-13,16-19H,4-7,14-15,20-21H2,1-3H3,(H,37,38) XHKSVIGBXZHIAJ-UHFFFAOYSA-N 764356 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-mesityl-6,7- dihydro-5H-benzo[7]annulene-3-carboxylic acid::US20250255848, Example 10 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764356 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764356&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239499 520665811 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626535 Cc1cc(C)c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(Cl)c1 InChI=1S/C33H33ClFNO2/c1-21-15-22(2)31(30(34)16-21)29-6-3-5-26-18-27(33(37)38)11-12-28(26)32(29)25-9-7-23(8-10-25)17-24-19-36(20-24)14-4-13-35/h7-12,15-18H,3-6,13-14,19-20H2,1-2H3,(H,37,38) SZDHHVMYOJUBBS-UHFFFAOYSA-N 764357 8-(2-chloro-4,6-dimethylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 11 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764357 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764357&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239604 520665812 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626536 Cc1ccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C)c1F InChI=1S/C33H33F2NO2/c1-21-7-13-28(22(2)32(21)35)30-6-3-5-26-18-27(33(37)38)12-14-29(26)31(30)25-10-8-23(9-11-25)17-24-19-36(20-24)16-4-15-34/h7-14,17-18H,3-6,15-16,19-20H2,1-2H3,(H,37,38) ZKIVYCINRVMXKL-UHFFFAOYSA-N 764358 8-(3-fluoro-2,4-dimethylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 12 Estrogen receptor Human 0.700 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764358 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764358&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239581 520665813 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626537 Cc1ccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C)c1Cl InChI=1S/C33H33ClFNO2/c1-21-7-13-28(22(2)32(21)34)30-6-3-5-26-18-27(33(37)38)12-14-29(26)31(30)25-10-8-23(9-11-25)17-24-19-36(20-24)16-4-15-35/h7-14,17-18H,3-6,15-16,19-20H2,1-2H3,(H,37,38) SQUPSYZZZGOKMT-UHFFFAOYSA-N 764359 8-(3-chloro-2,4-dimethylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 13 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764359 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764359&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239537 520665814 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626538 COc1cc(C)cc(C)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C34H36FNO3/c1-22-16-23(2)32(31(17-22)39-3)30-7-4-6-27-19-28(34(37)38)12-13-29(27)33(30)26-10-8-24(9-11-26)18-25-20-36(21-25)15-5-14-35/h8-13,16-19H,4-7,14-15,20-21H2,1-3H3,(H,37,38) MMCNNCFPQWOIGD-UHFFFAOYSA-N 764360 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methoxy-4,6- dimethylphenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 14 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764360 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764360&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239500 520665815 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626539 CC(F)(F)c1cc(F)ccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H31F4NO2/c1-33(36,37)30-18-26(35)11-13-28(30)29-5-2-4-24-17-25(32(39)40)10-12-27(24)31(29)23-8-6-21(7-9-23)16-22-19-38(20-22)15-3-14-34/h6-13,16-18H,2-5,14-15,19-20H2,1H3,(H,39,40) WBAGLRVJWCTACJ-UHFFFAOYSA-N 764361 8-(2-(1,1-difluoroethyl)-4-fluorophenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 15 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764361 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764361&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239632 520665816 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626540 O=C(O)c1ccc2c(c1)CCCC(c1c(Cl)cccc1C(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H28ClF4NO2/c33-28-7-2-6-27(32(35,36)37)30(28)26-5-1-4-23-17-24(31(39)40)12-13-25(23)29(26)22-10-8-20(9-11-22)16-21-18-38(19-21)15-3-14-34/h2,6-13,16-17H,1,3-5,14-15,18-19H2,(H,39,40) XVKRADSFYGZPKP-UHFFFAOYSA-N 764362 8-(2-chloro-6-(trifluoromethyl)phenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 16 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764362 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764362&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239611 520665817 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626541 O=C(O)c1ccc2c(c1)CCCC(c1c(Cl)cccc1OC(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H28ClF4NO3/c33-27-6-2-7-28(41-32(35,36)37)30(27)26-5-1-4-23-17-24(31(39)40)12-13-25(23)29(26)22-10-8-20(9-11-22)16-21-18-38(19-21)15-3-14-34/h2,6-13,16-17H,1,3-5,14-15,18-19H2,(H,39,40) LLGSYAXZXJRDCP-UHFFFAOYSA-N 764363 8-(2-chloro-6-(trifluoromethoxy)phenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 17 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764363&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239589 520665818 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626542 COc1cc(C)c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C)c1 InChI=1S/C34H36FNO3/c1-22-16-29(39-3)17-23(2)32(22)31-7-4-6-27-19-28(34(37)38)12-13-30(27)33(31)26-10-8-24(9-11-26)18-25-20-36(21-25)15-5-14-35/h8-13,16-19H,4-7,14-15,20-21H2,1-3H3,(H,37,38) KVDMGLNWQRXUDI-UHFFFAOYSA-N 764364 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(4-methoxy-2,6- dimethylphenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 18 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764364&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239503 520665819 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626543 CCc1ccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C(F)(F)F)c1 InChI=1S/C34H33F4NO2/c1-2-22-9-13-29(31(18-22)34(36,37)38)30-6-3-5-26-19-27(33(40)41)12-14-28(26)32(30)25-10-7-23(8-11-25)17-24-20-39(21-24)16-4-15-35/h7-14,17-19H,2-6,15-16,20-21H2,1H3,(H,40,41) ZRJVRJFPLJSHNQ-UHFFFAOYSA-N 764365 8-(4-ethyl-2-(trifluoromethyl)phenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 19 Estrogen receptor Human 0.200 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764365 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764365&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239585 520665820 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626544 O=C(O)c1ccc2c(c1)CCCC(c1c(F)cccc1C(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H28F5NO2/c33-14-3-15-38-18-21(19-38)16-20-8-10-22(11-9-20)29-25-13-12-24(31(39)40)17-23(25)4-1-5-26(29)30-27(32(35,36)37)6-2-7-28(30)34/h2,6-13,16-17H,1,3-5,14-15,18-19H2,(H,39,40) IZFIRRFLXWNYLN-UHFFFAOYSA-N 764366 8-(2-fluoro-6-(trifluoromethyl)phenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 20 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764366&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239613 520665821 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626545 Cc1cccc(Cl)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C32H31ClFNO2/c1-21-5-2-8-29(33)30(21)28-7-3-6-25-18-26(32(36)37)13-14-27(25)31(28)24-11-9-22(10-12-24)17-23-19-35(20-23)16-4-15-34/h2,5,8-14,17-18H,3-4,6-7,15-16,19-20H2,1H3,(H,36,37) AYPQAYMMXKTOCS-UHFFFAOYSA-N 764367 8-(2-chloro-6-methylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 21 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764367 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764367&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239549 520665822 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626546 COc1cccc(F)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C32H31F2NO3/c1-38-29-8-3-7-28(34)31(29)27-6-2-5-24-18-25(32(36)37)13-14-26(24)30(27)23-11-9-21(10-12-23)17-22-19-35(20-22)16-4-15-33/h3,7-14,17-18H,2,4-6,15-16,19-20H2,1H3,(H,36,37) FZJUFVDYZUNECW-UHFFFAOYSA-N 764368 8-(2-fluoro-6-methoxyphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 22 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764368 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764368&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239561 520665823 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626547 COc1cccc(Cl)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C32H31ClFNO3/c1-38-29-8-3-7-28(33)31(29)27-6-2-5-24-18-25(32(36)37)13-14-26(24)30(27)23-11-9-21(10-12-23)17-22-19-35(20-22)16-4-15-34/h3,7-14,17-18H,2,4-6,15-16,19-20H2,1H3,(H,36,37) FZBLFWKSYOPFIC-UHFFFAOYSA-N 764369 8-(2-chloro-6-methoxyphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 23 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764369 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764369&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239521 520665824 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626548 Cc1c(OC(F)(F)F)cccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H31F4NO3/c1-21-27(6-3-8-30(21)41-33(35,36)37)29-7-2-5-25-18-26(32(39)40)13-14-28(25)31(29)24-11-9-22(10-12-24)17-23-19-38(20-23)16-4-15-34/h3,6,8-14,17-18H,2,4-5,7,15-16,19-20H2,1H3,(H,39,40) HYINQAOJVPEFIE-UHFFFAOYSA-N 764370 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methyl-3- (trifluoromethoxy)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 24 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764370 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764370&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239623 520665825 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626549 CCc1cc(C(F)(F)F)ccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C34H33F4NO2/c1-2-24-19-28(34(36,37)38)12-14-29(24)31-6-3-5-26-18-27(33(40)41)11-13-30(26)32(31)25-9-7-22(8-10-25)17-23-20-39(21-23)16-4-15-35/h7-14,17-19H,2-6,15-16,20-21H2,1H3,(H,40,41) LQGFFVPCLKFCSF-UHFFFAOYSA-N 764371 8-(2-ethyl-4-(trifluoromethyl)phenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 25 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764371 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764371&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239519 520665826 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626550 Cc1cccc(F)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C32H31F2NO2/c1-21-5-2-8-29(34)30(21)28-7-3-6-25-18-26(32(36)37)13-14-27(25)31(28)24-11-9-22(10-12-24)17-23-19-35(20-23)16-4-15-33/h2,5,8-14,17-18H,3-4,6-7,15-16,19-20H2,1H3,(H,36,37) VYVLVXPVEYNASQ-UHFFFAOYSA-N 764372 8-(2-fluoro-6-methylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 26 Estrogen receptor Human 0.200 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764372 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764372&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239489 520665827 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626551 Cc1cc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C)cc1F InChI=1S/C33H33F2NO2/c1-21-16-31(35)22(2)15-30(21)29-6-3-5-26-18-27(33(37)38)11-12-28(26)32(29)25-9-7-23(8-10-25)17-24-19-36(20-24)14-4-13-34/h7-12,15-18H,3-6,13-14,19-20H2,1-2H3,(H,37,38) XMYQFGDKGBPFDV-UHFFFAOYSA-N 764373 8-(4-fluoro-2,5-dimethylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 27 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764373 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764373&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239633 520665828 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626552 Cc1cc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)ccc1C(F)F InChI=1S/C33H32F3NO2/c1-21-16-26(10-12-28(21)32(35)36)29-5-2-4-25-18-27(33(38)39)11-13-30(25)31(29)24-8-6-22(7-9-24)17-23-19-37(20-23)15-3-14-34/h6-13,16-18,32H,2-5,14-15,19-20H2,1H3,(H,38,39) LQZNBOBDMSABFY-UHFFFAOYSA-N 764374 8-(4-(difluoromethyl)-3-methylphenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 28 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764374&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239639 520665829 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626553 COc1cc(C(F)F)ccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H32F3NO3/c1-40-30-18-25(32(35)36)10-13-28(30)29-5-2-4-24-17-26(33(38)39)11-12-27(24)31(29)23-8-6-21(7-9-23)16-22-19-37(20-22)15-3-14-34/h6-13,16-18,32H,2-5,14-15,19-20H2,1H3,(H,38,39) FUYKLARHMSOYOO-UHFFFAOYSA-N 764375 8-(4-(difluoromethyl)-2-methoxyphenyl)-9- (4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 29 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764375&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239574 520665830 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626554 Cc1cccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c1C(F)F InChI=1S/C33H32F3NO2/c1-21-5-2-7-28(30(21)32(35)36)29-8-3-6-25-18-26(33(38)39)13-14-27(25)31(29)24-11-9-22(10-12-24)17-23-19-37(20-23)16-4-15-34/h2,5,7,9-14,17-18,32H,3-4,6,8,15-16,19-20H2,1H3,(H,38,39) DJHGKCCPGYCHDD-UHFFFAOYSA-N 764376 8-(2-(difluoromethyl)-3-methylphenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 30 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764376 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764376&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239511 520665831 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626555 COc1cc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)ccc1C(F)F InChI=1S/C33H32F3NO3/c1-40-30-18-25(10-13-29(30)32(35)36)27-5-2-4-24-17-26(33(38)39)11-12-28(24)31(27)23-8-6-21(7-9-23)16-22-19-37(20-22)15-3-14-34/h6-13,16-18,32H,2-5,14-15,19-20H2,1H3,(H,38,39) IYIFXVNNESBWRM-UHFFFAOYSA-N 764377 8-(4-(difluoromethyl)-3-methoxyphenyl)-9- (4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 31 Estrogen receptor Human 37.8 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764377 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764377&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239504 520665832 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626556 O=C(O)c1ccc2c(c1)CCCC(c1ccccc1CF)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H31F2NO2/c33-15-4-16-35-20-23(21-35)17-22-9-11-24(12-10-22)31-29-14-13-26(32(36)37)18-25(29)6-3-8-30(31)28-7-2-1-5-27(28)19-34/h1-2,5,7,9-14,17-18H,3-4,6,8,15-16,19-21H2,(H,36,37) YMJXMKWKJWZSJE-UHFFFAOYSA-N 764378 8-(2-(fluoromethyl)phenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 32 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764378 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764378&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239596 520665833 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626557 O=C(O)c1ccc2c(c1)CCCC(c1cccc(F)c1OC(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H29F4NO3/c33-14-3-15-37-18-21(19-37)16-20-8-10-22(11-9-20)29-25-13-12-24(31(38)39)17-23(25)4-1-5-26(29)27-6-2-7-28(34)30(27)40-32(35)36/h2,6-13,16-17,32H,1,3-5,14-15,18-19H2,(H,38,39) VGENXDXNHVXSBR-UHFFFAOYSA-N 764379 8-(2-(difluoromethoxy)-3-fluorophenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 33 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764379&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239483 520665834 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626558 O=C(O)c1ccc2c(c1)CCCC(c1cccc(Cl)c1OC(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H28ClF4NO3/c33-28-7-2-6-27(30(28)41-32(35,36)37)26-5-1-4-23-17-24(31(39)40)12-13-25(23)29(26)22-10-8-20(9-11-22)16-21-18-38(19-21)15-3-14-34/h2,6-13,16-17H,1,3-5,14-15,18-19H2,(H,39,40) BWDAKLAVZLRAEW-UHFFFAOYSA-N 764380 8-(3-chloro-2-(trifluoromethoxy)phenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 34 Estrogen receptor Human 0.700 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764380 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764380&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239498 520665835 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626559 O=C(O)c1ccc2c(c1)CCCC(C1CC13CCC3)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C31H34FNO2/c32-14-3-15-33-19-22(20-33)16-21-6-8-23(9-7-21)29-26-11-10-25(30(34)35)17-24(26)4-1-5-27(29)28-18-31(28)12-2-13-31/h6-11,16-17,28H,1-5,12-15,18-20H2,(H,34,35) NUTNFBKXRFWGJF-UHFFFAOYSA-N 764381 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(spiro[2.3]hexan-1- yl)-6,7-dihydro-5H-benzo[7]annulene-3- carboxylic acid, Isomer 1::US20250255848, Example 35 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764381 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764381&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 163263072 520665836 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626560 O=C(O)c1ccc2c(c1)CCCC(C1CC13CCC3)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C31H34FNO2/c32-14-3-15-33-19-22(20-33)16-21-6-8-23(9-7-21)29-26-11-10-25(30(34)35)17-24(26)4-1-5-27(29)28-18-31(28)12-2-13-31/h6-11,16-17,28H,1-5,12-15,18-20H2,(H,34,35) NUTNFBKXRFWGJF-UHFFFAOYSA-N 764382 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(spiro[2.3]hexan-1- yl)-6,7-dihydro-5H-benzo[7]annulene-3- carboxylic acid, Isomer 2::US20250255848, Example 36 Estrogen receptor Human 0.200 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764382&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 163263072 520665837 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626561 COc1ccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C(F)F)c1 InChI=1S/C33H32F3NO3/c1-40-26-11-13-28(30(18-26)32(35)36)29-5-2-4-24-17-25(33(38)39)10-12-27(24)31(29)23-8-6-21(7-9-23)16-22-19-37(20-22)15-3-14-34/h6-13,16-18,32H,2-5,14-15,19-20H2,1H3,(H,38,39) AOSIKLLLUSRUML-UHFFFAOYSA-N 764383 8-(2-(difluoromethyl)-4-methoxyphenyl)-9- (4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 37 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764383 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764383&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239546 520665838 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626562 O=C(O)c1ccc2c(c1)CCCC(c1cccc(F)c1CF)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H30F3NO2/c33-14-3-15-36-19-22(20-36)16-21-8-10-23(11-9-21)31-26-13-12-25(32(37)38)17-24(26)4-1-6-28(31)27-5-2-7-30(35)29(27)18-34/h2,5,7-13,16-17H,1,3-4,6,14-15,18-20H2,(H,37,38) ZRDBZRMRSZYIKG-UHFFFAOYSA-N 764384 8-(3-fluoro-2-(fluoromethyl)phenyl)-9-(4-((1- (3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 38 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764384 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764384&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239588 520665839 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626563 CCc1c(F)cccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H33F2NO2/c1-2-27-29(7-4-9-31(27)35)30-8-3-6-25-19-26(33(37)38)14-15-28(25)32(30)24-12-10-22(11-13-24)18-23-20-36(21-23)17-5-16-34/h4,7,9-15,18-19H,2-3,5-6,8,16-17,20-21H2,1H3,(H,37,38) OXGAOGYXRFJDPK-UHFFFAOYSA-N 764385 8-(2-ethyl-3-fluorophenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 39 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764385 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764385&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239577 520665840 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626564 COc1c(F)cccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C32H31F2NO3/c1-38-31-28(7-3-8-29(31)34)27-6-2-5-24-18-25(32(36)37)13-14-26(24)30(27)23-11-9-21(10-12-23)17-22-19-35(20-22)16-4-15-33/h3,7-14,17-18H,2,4-6,15-16,19-20H2,1H3,(H,36,37) FCIPBDNGEUURFJ-UHFFFAOYSA-N 764386 8-(3-fluoro-2-methoxyphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 40 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764386 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764386&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239582 520665841 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626565 COc1cccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c1C InChI=1S/C33H34FNO3/c1-22-28(7-4-9-31(22)38-2)30-8-3-6-26-19-27(33(36)37)14-15-29(26)32(30)25-12-10-23(11-13-25)18-24-20-35(21-24)17-5-16-34/h4,7,9-15,18-19H,3,5-6,8,16-17,20-21H2,1-2H3,(H,36,37) SRWVUMWZZYMLFL-UHFFFAOYSA-N 764387 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(3-methoxy-2- methylphenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 41 Estrogen receptor Human 0.700 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764387 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764387&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239634 520665842 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 626566 Cc1c(Cl)cccc1C1=C(c2ccc(C=C3CN(CCC(F)F)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H30ClF2NO/c1-20-26(5-3-7-29(20)32)28-6-2-4-24-17-25(36)12-13-27(24)31(28)23-10-8-21(9-11-23)16-22-18-35(19-22)15-14-30(33)34/h3,5,7-13,16-17,30,36H,2,4,6,14-15,18-19H2,1H3 BCGQDPLAPNJFKD-UHFFFAOYSA-N 764388 8-(3-chloro-2-methylphenyl)-9-(4-((1-(3,3- difluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulen-3-ol::US20250255848, Example 42 Estrogen receptor Human 6.40 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764388 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764388&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239536 520665843 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 645991 Cc1ccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C(F)F)c1 InChI=1S/C33H32F3NO2/c1-21-6-12-28(30(16-21)32(35)36)29-5-2-4-25-18-26(33(38)39)11-13-27(25)31(29)24-9-7-22(8-10-24)17-23-19-37(20-23)15-3-14-34/h6-13,16-18,32H,2-5,14-15,19-20H2,1H3,(H,38,39) VCJJDVDABFBPDE-UHFFFAOYSA-N 764389 8-(2-(difluoromethyl)-4-methylphenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 43 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764389 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764389&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239627 520665844 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 645992 Cc1cc(C(F)F)ccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H32F3NO2/c1-21-16-26(32(35)36)10-12-28(21)30-5-2-4-25-18-27(33(38)39)11-13-29(25)31(30)24-8-6-22(7-9-24)17-23-19-37(20-23)15-3-14-34/h6-13,16-18,32H,2-5,14-15,19-20H2,1H3,(H,38,39) OXEZRGSDOUYRSG-UHFFFAOYSA-N 764390 8-(4-(difluoromethyl)-2-methylphenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 44 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764390&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239605 520665845 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 645993 COc1ccc(C(F)F)c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c1 InChI=1S/C33H32F3NO3/c1-40-26-11-13-29(32(35)36)30(18-26)28-5-2-4-24-17-25(33(38)39)10-12-27(24)31(28)23-8-6-21(7-9-23)16-22-19-37(20-22)15-3-14-34/h6-13,16-18,32H,2-5,14-15,19-20H2,1H3,(H,38,39) KJWOHERIBWCIPR-UHFFFAOYSA-N 764391 8-(2-(difluoromethyl)-5-methoxyphenyl)-9- (4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 45 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764391&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239565 520665846 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 645994 CCc1c(Cl)cccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H33ClFNO2/c1-2-27-29(7-4-9-31(27)34)30-8-3-6-25-19-26(33(37)38)14-15-28(25)32(30)24-12-10-22(11-13-24)18-23-20-36(21-23)17-5-16-35/h4,7,9-15,18-19H,2-3,5-6,8,16-17,20-21H2,1H3,(H,37,38) ROZWJDZMNDGPCQ-UHFFFAOYSA-N 764392 8-(3-chloro-2-ethylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 46 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764392&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239554 520665847 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 645995 COc1ccc(C(F)(F)F)c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c1 InChI=1S/C33H31F4NO3/c1-41-26-11-13-30(33(35,36)37)29(18-26)28-5-2-4-24-17-25(32(39)40)10-12-27(24)31(28)23-8-6-21(7-9-23)16-22-19-38(20-22)15-3-14-34/h6-13,16-18H,2-5,14-15,19-20H2,1H3,(H,39,40) ZCUAZEVPKJQXAE-UHFFFAOYSA-N 764393 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(5-methoxy-2- (trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 47 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764393&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239567 520665848 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647038 O=C(O)c1ccc2c(c1)CCCC(c1ccc(C(F)(F)F)cc1C1CC1)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C35H33F4NO2/c36-15-2-16-40-20-23(21-40)17-22-5-7-25(8-6-22)33-29-13-11-27(34(41)42)18-26(29)3-1-4-31(33)30-14-12-28(35(37,38)39)19-32(30)24-9-10-24/h5-8,11-14,17-19,24H,1-4,9-10,15-16,20-21H2,(H,41,42) KTQKGRULYJFOKW-UHFFFAOYSA-N 764394 8-(2-cyclopropyl-4-(trifluoromethyl)phenyl)- 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 48 Estrogen receptor Human 0.900 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764394 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764394&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239568 520665849 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647039 COc1c(Cl)cccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C32H31ClFNO3/c1-38-31-28(7-3-8-29(31)33)27-6-2-5-24-18-25(32(36)37)13-14-26(24)30(27)23-11-9-21(10-12-23)17-22-19-35(20-22)16-4-15-34/h3,7-14,17-18H,2,4-6,15-16,19-20H2,1H3,(H,36,37) DLXRIESBAFLKNM-UHFFFAOYSA-N 764395 8-(3-chloro-2-methoxyphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 49 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764395 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764395&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239516 520665850 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647040 COc1cc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)ccc1C(F)(F)F InChI=1S/C33H31F4NO3/c1-41-30-18-25(11-13-29(30)33(35,36)37)27-5-2-4-24-17-26(32(39)40)10-12-28(24)31(27)23-8-6-21(7-9-23)16-22-19-38(20-22)15-3-14-34/h6-13,16-18H,2-5,14-15,19-20H2,1H3,(H,39,40) COIBODHLTKBVOD-UHFFFAOYSA-N 764396 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(3-methoxy-4- (trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 50 Estrogen receptor Human 8.50 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764396 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764396&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239556 520665851 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647041 O=C(O)c1ccc2c(c1)CCCC(c1ccc(C(F)F)cc1C(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C33H29F6NO2/c34-13-2-14-40-18-21(19-40)15-20-5-7-22(8-6-20)30-26-11-10-25(32(41)42)16-23(26)3-1-4-28(30)27-12-9-24(31(35)36)17-29(27)33(37,38)39/h5-12,15-17,31H,1-4,13-14,18-19H2,(H,41,42) NEAUEBBSTARLEE-UHFFFAOYSA-N 764397 8-(4-(difluoromethyl)-2- (trifluoromethyl)phenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 51 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764397 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764397&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239583 520665852 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647042 COc1cccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c1C(F)(F)F InChI=1S/C33H31F4NO3/c1-41-29-8-3-7-28(31(29)33(35,36)37)27-6-2-5-24-18-25(32(39)40)13-14-26(24)30(27)23-11-9-21(10-12-23)17-22-19-38(20-22)16-4-15-34/h3,7-14,17-18H,2,4-6,15-16,19-20H2,1H3,(H,39,40) ZURVQGCAOUJOQQ-UHFFFAOYSA-N 764398 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(3-methoxy-2- (trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 52 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764398 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764398&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239548 520665853 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647043 Cc1cc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)ccc1C(F)(F)F InChI=1S/C33H31F4NO2/c1-21-16-26(11-13-30(21)33(35,36)37)28-5-2-4-25-18-27(32(39)40)10-12-29(25)31(28)24-8-6-22(7-9-24)17-23-19-38(20-23)15-3-14-34/h6-13,16-18H,2-5,14-15,19-20H2,1H3,(H,39,40) MSQYFWNLRBKVAM-UHFFFAOYSA-N 764399 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(3-methyl-4- (trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 53 Estrogen receptor Human 1.20 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764399 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764399&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239515 520665854 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647044 O=C(O)c1ccc2c(c1)CCCC(c1ccc(C(F)F)cc1OC(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C33H29F6NO3/c34-13-2-14-40-18-21(19-40)15-20-5-7-22(8-6-20)30-26-11-10-25(32(41)42)16-23(26)3-1-4-28(30)27-12-9-24(31(35)36)17-29(27)43-33(37,38)39/h5-12,15-17,31H,1-4,13-14,18-19H2,(H,41,42) GTASQAGIUZIUPR-UHFFFAOYSA-N 764400 8-(4-(difluoromethyl)-2- (trifluoromethoxy)phenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 54 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764400 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764400&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239562 520665855 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647045 O=C(O)c1ccc2c(c1)CCCC(c1ccc(C(F)F)cc1)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H30F3NO2/c33-15-2-16-36-19-22(20-36)17-21-5-7-24(8-6-21)30-28(23-9-11-25(12-10-23)31(34)35)4-1-3-26-18-27(32(37)38)13-14-29(26)30/h5-14,17-18,31H,1-4,15-16,19-20H2,(H,37,38) XQRNPSKAGKVRNI-UHFFFAOYSA-N 764401 8-(4-(difluoromethyl)phenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 55 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764401 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764401&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239552 520665856 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647046 C[C@H]1CC[C@H](C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)CC1 InChI=1S/C32H38FNO2/c1-22-6-10-25(11-7-22)29-5-2-4-27-19-28(32(35)36)14-15-30(27)31(29)26-12-8-23(9-13-26)18-24-20-34(21-24)17-3-16-33/h8-9,12-15,18-19,22,25H,2-7,10-11,16-17,20-21H2,1H3,(H,35,36) KALILTUESSASSV-UHFFFAOYSA-N 764402 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(trans-4- methylcyclohexyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 56 Estrogen receptor Human 0.700 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764402 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764402&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239553 520665857 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647047 Cc1ccc(C(F)F)c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c1 InChI=1S/C33H32F3NO2/c1-21-6-12-29(32(35)36)30(16-21)28-5-2-4-25-18-26(33(38)39)11-13-27(25)31(28)24-9-7-22(8-10-24)17-23-19-37(20-23)15-3-14-34/h6-13,16-18,32H,2-5,14-15,19-20H2,1H3,(H,38,39) PGMGHUQAWSFNGE-UHFFFAOYSA-N 764403 8-(2-(difluoromethyl)-5-methylpheny1)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 57 Estrogen receptor Human 0.700 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764403 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764403&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239573 520665858 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647048 O=C(O)c1ccc2c(c1)CCCC(c1ccccc1C(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C32H30F3NO2/c33-15-4-16-36-19-22(20-36)17-21-9-11-23(12-10-21)30-26-14-13-25(32(37)38)18-24(26)5-3-8-28(30)27-6-1-2-7-29(27)31(34)35/h1-2,6-7,9-14,17-18,31H,3-5,8,15-16,19-20H2,(H,37,38) AZFZPANAGSJVSY-UHFFFAOYSA-N 764404 8-(2-(difluoromethyl)phenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 58 Estrogen receptor Human 0.200 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764404&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239622 520665859 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647049 COc1cc(C(F)(F)F)ccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H31F4NO3/c1-41-30-18-26(33(35,36)37)11-13-28(30)29-5-2-4-24-17-25(32(39)40)10-12-27(24)31(29)23-8-6-21(7-9-23)16-22-19-38(20-22)15-3-14-34/h6-13,16-18H,2-5,14-15,19-20H2,1H3,(H,39,40) GNPMVSLIXOPFMB-UHFFFAOYSA-N 764405 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methoxy-4- (trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 59 Estrogen receptor Human 0.900 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764405 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764405&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239601 520665860 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647050 COc1cccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c1C(F)F InChI=1S/C33H32F3NO3/c1-40-29-8-3-7-28(31(29)32(35)36)27-6-2-5-24-18-25(33(38)39)13-14-26(24)30(27)23-11-9-21(10-12-23)17-22-19-37(20-22)16-4-15-34/h3,7-14,17-18,32H,2,4-6,15-16,19-20H2,1H3,(H,38,39) AJFBGUOMKKCCHB-UHFFFAOYSA-N 764406 8-(2-(difluoromethyl)-3-methoxyphenyl)-9- (4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 60 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764406&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239606 520665861 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647051 C[C@H]1CC[C@@H](C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)CC1 InChI=1S/C32H38FNO2/c1-22-6-10-25(11-7-22)29-5-2-4-27-19-28(32(35)36)14-15-30(27)31(29)26-12-8-23(9-13-26)18-24-20-34(21-24)17-3-16-33/h8-9,12-15,18-19,22,25H,2-7,10-11,16-17,20-21H2,1H3,(H,35,36) KALILTUESSASSV-UHFFFAOYSA-N 764407 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(cis-4- methylcyclohexyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 61 Estrogen receptor Human 0.900 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764407 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764407&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239553 520665862 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647052 COc1ccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C(F)(F)F)c1 InChI=1S/C33H31F4NO3/c1-41-26-11-13-28(30(18-26)33(35,36)37)29-5-2-4-24-17-25(32(39)40)10-12-27(24)31(29)23-8-6-21(7-9-23)16-22-19-38(20-22)15-3-14-34/h6-13,16-18H,2-5,14-15,19-20H2,1H3,(H,39,40) JCMKNGHMMRZDKD-UHFFFAOYSA-N 764408 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(4-methoxy-2- (trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 62 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764408 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764408&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239534 520665863 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647053 COc1c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)cccc1C(F)(F)F InChI=1S/C33H31F4NO3/c1-41-31-28(7-3-8-29(31)33(35,36)37)27-6-2-5-24-18-25(32(39)40)13-14-26(24)30(27)23-11-9-21(10-12-23)17-22-19-38(20-22)16-4-15-34/h3,7-14,17-18H,2,4-6,15-16,19-20H2,1H3,(H,39,40) IRHPSUHTSJZGNB-UHFFFAOYSA-N 764409 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methoxy-3- (trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 63 Estrogen receptor Human 1.000 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764409&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239638 520665864 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647054 O=C(O)c1ccc2c(c1)CCCC(c1cccc3c1CCCO3)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C34H34FNO3/c35-16-4-17-36-21-24(22-36)19-23-10-12-25(13-11-23)33-28-15-14-27(34(37)38)20-26(28)5-1-7-31(33)29-6-2-9-32-30(29)8-3-18-39-32/h2,6,9-15,19-20H,1,3-5,7-8,16-18,21-22H2,(H,37,38) XAZVDCZHIPZEOG-UHFFFAOYSA-N 764410 8-(chroman-5-yl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 64 Estrogen receptor Human 3.10 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764410 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764410&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239533 520665865 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647055 CC1(C)CCC(C2=C(c3ncc(C=C4CN(CCCF)C4)cc3F)c3ccc(C(=O)O)cc3CCC2)CC1 InChI=1S/C32H38F2N2O2/c1-32(2)11-9-23(10-12-32)26-6-3-5-24-17-25(31(37)38)7-8-27(24)29(26)30-28(34)16-21(18-35-30)15-22-19-36(20-22)14-4-13-33/h7-8,15-18,23H,3-6,9-14,19-20H2,1-2H3,(H,37,38) VBVSZMYOINQVGW-UHFFFAOYSA-N 764411 8-(4,4-dimethylcyclohexyl)-9-(3-fluoro-5-((1- (3-fluoropropyl)azetidin-3- ylidene)methyl)pyridin-2-yl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 65 Estrogen receptor Human 0.800 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764411 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764411&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239602 520665866 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647056 CC1(C)CCC(C2=C(c3ncc(C=C4CN(CCC(F)F)C4)cc3F)c3ccc(C(=O)O)cc3CCC2)CC1 InChI=1S/C32H37F3N2O2/c1-32(2)11-8-22(9-12-32)25-5-3-4-23-16-24(31(38)39)6-7-26(23)29(25)30-27(33)15-20(17-36-30)14-21-18-37(19-21)13-10-28(34)35/h6-7,14-17,22,28H,3-5,8-13,18-19H2,1-2H3,(H,38,39) HLBKELZOCDPMSU-UHFFFAOYSA-N 764412 9-(5-((1-(3,3-difluoropropyl)azetidin-3- ylidene)methyl)-3-fluoropyridin-2-yl)-8-(4,4- dimethylcyclohexyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 66 Estrogen receptor Human 1.70 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764412 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764412&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239853 520665867 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647057 O=C(O)c1ccc2c(c1)CCCC(c1cccc3c1OCCC3)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C34H34FNO3/c35-16-4-17-36-21-24(22-36)19-23-10-12-25(13-11-23)32-29-15-14-28(34(37)38)20-27(29)6-2-8-30(32)31-9-1-5-26-7-3-18-39-33(26)31/h1,5,9-15,19-20H,2-4,6-8,16-18,21-22H2,(H,37,38) WVUKWMPYDRVBRZ-UHFFFAOYSA-N 764413 8-(chroman-8-yl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 67 Estrogen receptor Human 1.000 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764413 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764413&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239619 520665868 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647058 CC1(C)CCC(C2CCCc3cc(C(=O)O)ccc3C2c2ccc(C=C3CN(CCCF)C3)cc2)CC1 InChI=1S/C33H42FNO2/c1-33(2)15-13-25(14-16-33)29-6-3-5-27-20-28(32(36)37)11-12-30(27)31(29)26-9-7-23(8-10-26)19-24-21-35(22-24)18-4-17-34/h7-12,19-20,25,29,31H,3-6,13-18,21-22H2,1-2H3,(H,36,37) CYGJEXFUSLPMBZ-UHFFFAOYSA-N 764414 8-(4,4-dimethylcyclohexyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 68 Estrogen receptor Human 0.700 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764414&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 177691960 520665869 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647059 O=C(O)c1ccc2c(c1)CCCC(c1ccc(Cl)cc1Cl)=C2c1ccc(C=C2CN(CC(F)CF)C2)cc1 InChI=1S/C31H27Cl2F2NO2/c32-24-9-11-27(29(33)14-24)28-3-1-2-22-13-23(31(37)38)8-10-26(22)30(28)21-6-4-19(5-7-21)12-20-16-36(17-20)18-25(35)15-34/h4-14,25H,1-3,15-18H2,(H,37,38) XCJCMHPIAJWAQQ-UHFFFAOYSA-N 764415 8-(2,4-dichlorophenyl)-9-(4-((1-(2,3- difluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid, Isomer 1::US20250255848, Example 69 Estrogen receptor Human 1.30 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764415 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764415&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239547 520665870 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647060 O=C(O)c1ccc2c(c1)CCCC(c1ccc(Cl)cc1Cl)=C2c1ccc(C=C2CN(CC(F)CF)C2)cc1 InChI=1S/C31H27Cl2F2NO2/c32-24-9-11-27(29(33)14-24)28-3-1-2-22-13-23(31(37)38)8-10-26(22)30(28)21-6-4-19(5-7-21)12-20-16-36(17-20)18-25(35)15-34/h4-14,25H,1-3,15-18H2,(H,37,38) XCJCMHPIAJWAQQ-UHFFFAOYSA-N 764416 8-(2,4-dichlorophenyl)-9-(4-((1-(2,3- difluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid, Isomer 2::US20250255848, Example 70 Estrogen receptor Human 1.80 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764416&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239547 520665871 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647061 COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C34H30F7NO3/c1-45-29-17-25(33(36,37)38)16-28(34(39,40)41)31(29)27-5-2-4-23-15-24(32(43)44)10-11-26(23)30(27)22-8-6-20(7-9-22)14-21-18-42(19-21)13-3-12-35/h6-11,14-17H,2-5,12-13,18-19H2,1H3,(H,43,44) XHVFNGGUFIRBRW-UHFFFAOYSA-N 764417 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methoxy-4,6- bis(trifluoromethyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 71 Estrogen receptor Human 0.500 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764417 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764417&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239636 520665872 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647062 Cc1cc(C)c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(C(F)(F)F)c1 InChI=1S/C34H33F4NO2/c1-21-15-22(2)31(30(16-21)34(36,37)38)29-6-3-5-26-18-27(33(40)41)11-12-28(26)32(29)25-9-7-23(8-10-25)17-24-19-39(20-24)14-4-13-35/h7-12,15-18H,3-6,13-14,19-20H2,1-2H3,(H,40,41) BVZRPQGWNDPGSC-UHFFFAOYSA-N 764418 8-(2,4-dimethyl-6-(trifluoromethyl)phenyl)-9- (4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 72 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764418&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239616 520665873 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647063 Cc1cc(C(F)(F)F)ccc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H31F4NO2/c1-21-16-27(33(35,36)37)11-13-28(21)30-5-2-4-25-18-26(32(39)40)10-12-29(25)31(30)24-8-6-22(7-9-24)17-23-19-38(20-23)15-3-14-34/h6-13,16-18H,2-5,14-15,19-20H2,1H3,(H,39,40) KHDUMPIJPFEJQI-UHFFFAOYSA-N 764419 8-(3-fluoro-2-methyl-4- (trifluoromethyl)phenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 73 Estrogen receptor Human 0.300 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764419&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 163263152 520665874 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647064 CCc1cccc(CC)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C35H38FNO2/c1-3-26-8-5-9-27(4-2)33(26)32-11-6-10-29-21-30(35(38)39)16-17-31(29)34(32)28-14-12-24(13-15-28)20-25-22-37(23-25)19-7-18-36/h5,8-9,12-17,20-21H,3-4,6-7,10-11,18-19,22-23H2,1-2H3,(H,38,39) BLAGDEFXABXPGF-UHFFFAOYSA-N 764420 8-(2,6-diethylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 74 Estrogen receptor Human 0.800 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764420&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239563 520665875 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647065 Cc1ccc(F)c(C)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H33F2NO2/c1-21-7-14-30(35)22(2)31(21)29-6-3-5-26-18-27(33(37)38)12-13-28(26)32(29)25-10-8-23(9-11-25)17-24-19-36(20-24)16-4-15-34/h7-14,17-18H,3-6,15-16,19-20H2,1-2H3,(H,37,38) SFYQIHDNUYETAI-UHFFFAOYSA-N 764421 8-(3-fluoro-2,6-dimethylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 75 Estrogen receptor Human 0.200 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764421&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239510 520665876 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647066 Cc1cc(C)c(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c(F)c1 InChI=1S/C33H33F2NO2/c1-21-15-22(2)31(30(35)16-21)29-6-3-5-26-18-27(33(37)38)11-12-28(26)32(29)25-9-7-23(8-10-25)17-24-19-36(20-24)14-4-13-34/h7-12,15-18H,3-6,13-14,19-20H2,1-2H3,(H,37,38) RBGMYEYFKVTYTP-UHFFFAOYSA-N 764422 8-(2-fluoro-4,6-dimethylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 76 Estrogen receptor Human 0.200 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764422&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239587 520665877 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647067 Cc1cccc(OC(F)(F)F)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H31F4NO3/c1-21-5-2-8-29(41-33(35,36)37)30(21)28-7-3-6-25-18-26(32(39)40)13-14-27(25)31(28)24-11-9-22(10-12-24)17-23-19-38(20-23)16-4-15-34/h2,5,8-14,17-18H,3-4,6-7,15-16,19-20H2,1H3,(H,39,40) AXBRUMNHGNQWML-UHFFFAOYSA-N 764423 9-(4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-8-(2-methyl-6- (trifluoromethoxy)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 77 Estrogen receptor Human 0.700 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764423 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764423&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239488 520665878 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647068 Cc1cc(C(F)(F)F)c(C)cc1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C34H33F4NO2/c1-21-16-31(34(36,37)38)22(2)15-30(21)29-6-3-5-26-18-27(33(40)41)11-12-28(26)32(29)25-9-7-23(8-10-25)17-24-19-39(20-24)14-4-13-35/h7-12,15-18H,3-6,13-14,19-20H2,1-2H3,(H,40,41) KIWCCVDYNMOPDU-UHFFFAOYSA-N 764424 8-(2,5-dimethyl-4-(trifluoromethyl)phenyl)-9- (4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 78 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764424&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239576 520665879 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647069 O=C(O)c1ccc2c(c1)CCCC(c1cccc(C(F)(F)F)c1C(F)(F)F)=C2c1ccc(C=C2CN(CCCF)C2)cc1 InChI=1S/C33H28F7NO2/c34-14-3-15-41-18-21(19-41)16-20-8-10-22(11-9-20)29-25-13-12-24(31(42)43)17-23(25)4-1-5-26(29)27-6-2-7-28(32(35,36)37)30(27)33(38,39)40/h2,6-13,16-17H,1,3-5,14-15,18-19H2,(H,42,43) LEWWZNYGBJCSAA-UHFFFAOYSA-N 764425 8-(2,3-bis(trifluoromethyl)phenyl)-9-(4-((1- (3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 79 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764425 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764425&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239570 520665880 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647070 CCc1cc(C)cc(CC)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C36H40FNO2/c1-4-27-18-24(3)19-28(5-2)34(27)33-9-6-8-30-21-31(36(39)40)14-15-32(30)35(33)29-12-10-25(11-13-29)20-26-22-38(23-26)17-7-16-37/h10-15,18-21H,4-9,16-17,22-23H2,1-3H3,(H,39,40) MLKLSMXVUJMZON-UHFFFAOYSA-N 764426 8-(2,6-diethyl-4-methylphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 80 Estrogen receptor Human 1.20 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764426 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764426&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239520 520665881 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647071 COc1cccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)c1OC InChI=1S/C33H34FNO4/c1-38-30-9-4-8-29(32(30)39-2)28-7-3-6-25-19-26(33(36)37)14-15-27(25)31(28)24-12-10-22(11-13-24)18-23-20-35(21-23)17-5-16-34/h4,8-15,18-19H,3,5-7,16-17,20-21H2,1-2H3,(H,36,37) XHZNOHKCFXAJDJ-UHFFFAOYSA-N 764427 8-(2,3-dimethoxyphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 81 Estrogen receptor Human 0.700 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764427&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239612 520665882 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647072 COc1ccc(C2=C(c3ccc(C=C4CN(CCCF)C4)cc3)c3ccc(C(=O)O)cc3CCC2)cc1OC InChI=1S/C33H34FNO4/c1-38-30-14-12-26(19-31(30)39-2)28-6-3-5-25-18-27(33(36)37)11-13-29(25)32(28)24-9-7-22(8-10-24)17-23-20-35(21-23)16-4-15-34/h7-14,17-19H,3-6,15-16,20-21H2,1-2H3,(H,36,37) FMCRXXJZNKOHNX-UHFFFAOYSA-N 764428 8-(3,4-dimethoxyphenyl)-9-(4-((1-(3- fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 82 Estrogen receptor Human 1.40 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764428&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239484 520665883 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647073 COc1cc(Cl)cc(C)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C33H33ClFNO3/c1-21-15-27(34)18-30(39-2)31(21)29-6-3-5-25-17-26(33(37)38)11-12-28(25)32(29)24-9-7-22(8-10-24)16-23-19-36(20-23)14-4-13-35/h7-12,15-18H,3-6,13-14,19-20H2,1-2H3,(H,37,38) DIQAPWBNEQLTES-UHFFFAOYSA-N 764429 8-(4-chloro-2-methoxy-6-methylphenyl)-9-(4- ((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7-dihydro-5H- benzo[7]annulene-3-carboxylic acid::US20250255848, Example 83 Estrogen receptor Human 0.400 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764429 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764429&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239513 520665884 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 647074 Cc1ccc(C(F)(F)F)c(C)c1C1=C(c2ccc(C=C3CN(CCCF)C3)cc2)c2ccc(C(=O)O)cc2CCC1 InChI=1S/C34H33F4NO2/c1-21-7-14-30(34(36,37)38)22(2)31(21)29-6-3-5-26-18-27(33(40)41)12-13-28(26)32(29)25-10-8-23(9-11-25)17-24-19-39(20-24)16-4-15-35/h7-14,17-18H,3-6,15-16,19-20H2,1-2H3,(H,40,41) APMPIFOQFCAONF-UHFFFAOYSA-N 764430 8-(2,6-dimethyl-3-(trifluoromethyl)phenyl)-9- (4-((1-(3-fluoropropyl)azetidin-3- ylidene)methyl)phenyl)-6,7- dihydro-5 H-benzo[7]annulene-3-carboxylic acid::US20250255848, Example 84 Estrogen receptor Human 0.600 US Patent 10.7270/Q2XP79P7 US20250255848 BERNARDELLI, P; EL-AHMAD, Y; PETIT, F; SLOWINSKI, F 8/14/2025 11/24/2025 Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764430 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=369&target=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764430&enzyme=Estrogen+receptor&column=ki&startPg=0&Increment=50&submit=Search 169239485 520665885 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 3ERT,3ERD,1R5K,1L2I,2IOK,2OUZ,1ERR,1ERE,3DT3,2YJA,3L03,3HM1,3HLV,3UUC,1QKU Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7