BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
711920	CC(C)(C)c1nc(C(=O)NCc2cc(F)c(-c3ncnn4cc(N5CCOCC5)cc34)cc2Cl)no1	InChI=1S/C24H25ClFN7O3/c1-24(2,3)23-30-21(31-36-23)22(34)27-11-14-8-18(26)16(10-17(14)25)20-19-9-15(12-33(19)29-13-28-20)32-4-6-35-7-5-32/h8-10,12-13H,4-7,11H2,1-3H3,(H,27,34)	RAPYLRUXFFYAEY-UHFFFAOYSA-N	765378	US12391697, Example 1	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765378&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319472	520666833							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711921	Cc1c(CNC(=O)c2nc(C(C)(C)C)no2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C25H28FN7O3/c1-15-16(12-27-22(34)23-30-24(31-36-23)25(2,3)4)5-6-18(20(15)26)21-19-11-17(13-33(19)29-14-28-21)32-7-9-35-10-8-32/h5-6,11,13-14H,7-10,12H2,1-4H3,(H,27,34)	XOSSZKWIGUFNSL-UHFFFAOYSA-N	765379	US12391697, Example 2	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765379&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318944	520666834							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711922	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1nnc(C(C)(C)C(F)F)o1	InChI=1S/C25H24F2N8O2/c1-14-7-15(20-19-8-17(12-35(19)31-13-29-20)18-10-30-34(4)11-18)5-6-16(14)9-28-21(36)22-32-33-24(37-22)25(2,3)23(26)27/h5-8,10-13,23H,9H2,1-4H3,(H,28,36)	QONGIRVVQBIPRR-UHFFFAOYSA-N	765380	US12391697, Example 3	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765380&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319231	520666835							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711923	Cc1cc(-c2ncnn3cc(N4CCN(C)CC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H32N8O2/c1-17-12-18(6-7-19(17)14-27-24(35)23-30-25(36-31-23)26(2,3)4)22-21-13-20(15-34(21)29-16-28-22)33-10-8-32(5)9-11-33/h6-7,12-13,15-16H,8-11,14H2,1-5H3,(H,27,35)	HXDNLQFIBDHVNF-UHFFFAOYSA-N	765381	US12391697, Example 4	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765381&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319176	520666836							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711924	Cc1cc(-c2ncnn3cc(N4CCOCC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H29N7O3/c1-16-11-17(5-6-18(16)13-26-23(33)22-29-24(35-30-22)25(2,3)4)21-20-12-19(14-32(20)28-15-27-21)31-7-9-34-10-8-31/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,33)	XOPYTOLSUHIINM-UHFFFAOYSA-N	765382	US12391697, Example 5	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765382&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319041	520666837							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711925	Cc1cc(-c2ncnn3cc(C4=CCOCC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H28N6O3/c1-16-11-18(5-6-19(16)13-27-24(33)23-30-25(35-31-23)26(2,3)4)22-21-12-20(14-32(21)29-15-28-22)17-7-9-34-10-8-17/h5-7,11-12,14-15H,8-10,13H2,1-4H3,(H,27,33)	CLMCYGWZLOSSAL-UHFFFAOYSA-N	765383	US12391697, Example 6	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765383&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156345504	520666838							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711926	COCCn1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C)c4)ncnn3c2)cn1	InChI=1S/C27H30N8O3/c1-17-10-18(6-7-19(17)12-28-25(36)24-32-26(38-33-24)27(2,3)4)23-22-11-20(15-35(22)31-16-29-23)21-13-30-34(14-21)8-9-37-5/h6-7,10-11,13-16H,8-9,12H2,1-5H3,(H,28,36)	FIJJSGKOOLNZCA-UHFFFAOYSA-N	765384	US12391697, Example 7	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765384&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319345	520666839							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711927	COC1CN(c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C)c4)ncnn3c2)C1	InChI=1S/C25H29N7O3/c1-15-8-16(6-7-17(15)10-26-23(33)22-29-24(35-30-22)25(2,3)4)21-20-9-18(11-32(20)28-14-27-21)31-12-19(13-31)34-5/h6-9,11,14,19H,10,12-13H2,1-5H3,(H,26,33)	DXWXKFRFSKAKFQ-UHFFFAOYSA-N	765385	US12391697, Example 8	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765385&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319206	520666840							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711928	Cc1cc(-c2ncnn3cc(-c4ccn(C)n4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H26N8O2/c1-15-10-16(6-7-17(15)12-26-23(34)22-29-24(35-31-22)25(2,3)4)21-20-11-18(13-33(20)28-14-27-21)19-8-9-32(5)30-19/h6-11,13-14H,12H2,1-5H3,(H,26,34)	OHZXNHNJUKXKQS-UHFFFAOYSA-N	765386	US12391697, Example 9	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765386&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319326	520666841							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711929	Cc1cc(-c2ncnn3cc(-c4cnn(CC(F)F)c4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H26F2N8O2/c1-15-7-16(5-6-17(15)9-29-24(37)23-33-25(38-34-23)26(2,3)4)22-20-8-18(12-36(20)32-14-30-22)19-10-31-35(11-19)13-21(27)28/h5-8,10-12,14,21H,9,13H2,1-4H3,(H,29,37)	MRSZWTXMDFLOHU-UHFFFAOYSA-N	765387	US12391697, Example 10	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765387&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319217	520666842							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711930	Cc1cc(-c2ncnn3cc(N4CCC(F)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H28FN7O2/c1-15-9-16(5-6-17(15)11-27-23(34)22-30-24(35-31-22)25(2,3)4)21-20-10-19(13-33(20)29-14-28-21)32-8-7-18(26)12-32/h5-6,9-10,13-14,18H,7-8,11-12H2,1-4H3,(H,27,34)	GFXAYEDYGDCXDR-UHFFFAOYSA-N	765388	US12391697, Example 11	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765388&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319154	520666843							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711931	Cc1cc(-c2ncnn3cc(N4CCC(F)(F)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H27F2N7O2/c1-15-9-16(5-6-17(15)11-28-22(35)21-31-23(36-32-21)24(2,3)4)20-19-10-18(12-34(19)30-14-29-20)33-8-7-25(26,27)13-33/h5-6,9-10,12,14H,7-8,11,13H2,1-4H3,(H,28,35)	IKCKHIMMCOQLTO-UHFFFAOYSA-N	765389	US12391697, Example 12	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765389&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319451	520666844							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711932	CC(C)(C)c1noc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2Cl)n1	InChI=1S/C24H25ClFN7O3/c1-24(2,3)23-30-22(36-31-23)21(34)27-11-14-4-5-16(19(26)18(14)25)20-17-10-15(12-33(17)29-13-28-20)32-6-8-35-9-7-32/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,27,34)	QFKFKHQOKGHMNA-UHFFFAOYSA-N	765390	US12391697, Example 14	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765390&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319516	520666845							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711933	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2Cl)no1	InChI=1S/C24H26ClN7O3/c1-24(2,3)23-29-21(30-35-23)22(33)26-12-16-5-4-15(10-18(16)25)20-19-11-17(13-32(19)28-14-27-20)31-6-8-34-9-7-31/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H,26,33)	NCOSSQPNPIPVLA-UHFFFAOYSA-N	765391	US12391697, Example 15	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765391&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318892	520666846							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711934	Cc1cc(-c2ccnc3cc(-c4cnn(C)c4)nn23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H26N8O2/c1-15-10-16(6-7-17(15)12-27-23(34)22-29-24(35-31-22)25(2,3)4)20-8-9-26-21-11-19(30-33(20)21)18-13-28-32(5)14-18/h6-11,13-14H,12H2,1-5H3,(H,27,34)	IAESVXSZLZKTAF-UHFFFAOYSA-N	765392	US12391697, Example 16	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765392&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319069	520666847							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711935	Cc1cc(-c2ccnn3cccc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C22H23N5O2/c1-14-12-15(17-9-10-24-27-11-5-6-18(17)27)7-8-16(14)13-23-20(28)19-25-21(29-26-19)22(2,3)4/h5-12H,13H2,1-4H3,(H,23,28)	BGDVNPQDLMRGQC-UHFFFAOYSA-N	765393	US12391697, Example 17	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765393&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319255	520666848							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711936	Cc1cc(-c2ccnn3cccc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C22H23N5O2/c1-14-12-15(17-9-10-24-27-11-5-6-18(17)27)7-8-16(14)13-23-19(28)20-25-21(26-29-20)22(2,3)4/h5-12H,13H2,1-4H3,(H,23,28)	WDQKSWRGKCIXHK-UHFFFAOYSA-N	765394	US12391697, Example 18	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765394&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318999	520666849							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711937	Cc1cc(-c2ncnn3ccc(F)c23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C21H21FN6O2/c1-12-9-13(16-17-15(22)7-8-28(17)25-11-24-16)5-6-14(12)10-23-19(29)18-26-20(30-27-18)21(2,3)4/h5-9,11H,10H2,1-4H3,(H,23,29)	STWVYACYAKOGCY-UHFFFAOYSA-N	765395	US12391697, Example 19	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765395&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319036	520666850							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711938	Cc1cc(-c2ncnn3cccc23)ccc1CNC(=O)c1coc(C(C)(F)F)n1	InChI=1S/C20H17F2N5O2/c1-12-8-13(17-16-4-3-7-27(16)25-11-24-17)5-6-14(12)9-23-18(28)15-10-29-19(26-15)20(2,21)22/h3-8,10-11H,9H2,1-2H3,(H,23,28)	PGGGYMXZGVPAQA-UHFFFAOYSA-N	765396	US12391697, Example 20	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765396&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319101	520666851							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711939	Cc1cc(-c2ccnn3ccnc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C21H22N6O2/c1-13-11-14(16-7-8-24-27-10-9-22-18(16)27)5-6-15(13)12-23-19(28)17-25-20(29-26-17)21(2,3)4/h5-11H,12H2,1-4H3,(H,23,28)	YRGWYRNKDRCMSQ-UHFFFAOYSA-N	765397	US12391697, Example 21	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765397&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319081	520666852							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711940	Cc1cc(-c2ccnc3cc(N4CCOCC4)nn23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H29N7O3/c1-16-13-17(5-6-18(16)15-27-23(33)22-28-24(35-30-22)25(2,3)4)19-7-8-26-20-14-21(29-32(19)20)31-9-11-34-12-10-31/h5-8,13-14H,9-12,15H2,1-4H3,(H,27,33)	STERWYZCOZTMOA-UHFFFAOYSA-N	765398	US12391697, Example 22	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765398&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319155	520666853							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711941	CO[C@H]1CCN(c2cc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(C)c4)ncnn3c2)C1	InChI=1S/C26H31N7O3/c1-16-10-17(6-7-18(16)12-27-23(34)24-30-25(31-36-24)26(2,3)4)22-21-11-19(13-33(21)29-15-28-22)32-9-8-20(14-32)35-5/h6-7,10-11,13,15,20H,8-9,12,14H2,1-5H3,(H,27,34)	WIFJCBAFCJAIGS-UHFFFAOYSA-N	765399	(R)-3-(tert-butyl)-N-(4-(6-(3-methoxypyrrolidin-1-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide::US12391697, Example 23	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765399&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319026	520666854							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711942	CO[C@@H]1CCN(c2cc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(C)c4)ncnn3c2)C1	InChI=1S/C26H31N7O3/c1-16-10-17(6-7-18(16)12-27-23(34)24-30-25(31-36-24)26(2,3)4)22-21-11-19(13-33(21)29-15-28-22)32-9-8-20(14-32)35-5/h6-7,10-11,13,15,20H,8-9,12,14H2,1-5H3,(H,27,34)	WIFJCBAFCJAIGS-UHFFFAOYSA-N	765400	US12391697, Example 24	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765400&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319136	520666855							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711943	Cc1c(CNC(=O)c2nc(C(C)(C)C)no2)ccc(-c2ncnn3cc(N4CCN(C)[C@H](C)C4)cc23)c1F	InChI=1S/C27H33FN8O2/c1-16-13-35(10-9-34(16)6)19-11-21-23(30-15-31-36(21)14-19)20-8-7-18(17(2)22(20)28)12-29-24(37)25-32-26(33-38-25)27(3,4)5/h7-8,11,14-16H,9-10,12-13H2,1-6H3,(H,29,37)	WHZDILGETZVPTO-UHFFFAOYSA-N	765401	(R)-3-(tert-butyl)-N-(4-(6-(3,4-dimethylpiperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-3-fluoro-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide::US12391697, Example 25	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765401&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319191	520666856							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711944	Cc1c(CNC(=O)c2nc(C(C)(C)C)no2)ccc(-c2ncnn3cc(N4CCN(C)[C@@H](C)C4)cc23)c1F	InChI=1S/C27H33FN8O2/c1-16-13-35(10-9-34(16)6)19-11-21-23(30-15-31-36(21)14-19)20-8-7-18(17(2)22(20)28)12-29-24(37)25-32-26(33-38-25)27(3,4)5/h7-8,11,14-16H,9-10,12-13H2,1-6H3,(H,29,37)	WHZDILGETZVPTO-UHFFFAOYSA-N	765402	(S)-3-(tert-butyl)-N-(4-(6-(3,4-dimethylpiperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-3-fluoro-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide ::US12391697, Example 26	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765402&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319143	520666857							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711945	Cc1cc(-c2ncnn3cc(N4CCN(C)[C@H](C)C4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C27H34N8O2/c1-17-11-19(7-8-20(17)13-28-24(36)25-31-26(32-37-25)27(3,4)5)23-22-12-21(15-35(22)30-16-29-23)34-10-9-33(6)18(2)14-34/h7-8,11-12,15-16,18H,9-10,13-14H2,1-6H3,(H,28,36)	SBWWKQSKIXZRQO-UHFFFAOYSA-N	765403	(S)-3-(tert-butyl)-N-(4-(6-(3,4-dimethylpiperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide::US12391697, Example 27	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765403&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319135	520666858							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711946	Cc1cc(-c2ncnn3cc(N4CCN(C)[C@@H](C)C4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C27H34N8O2/c1-17-11-19(7-8-20(17)13-28-24(36)25-31-26(32-37-25)27(3,4)5)23-22-12-21(15-35(22)30-16-29-23)34-10-9-33(6)18(2)14-34/h7-8,11-12,15-16,18H,9-10,13-14H2,1-6H3,(H,28,36)	SBWWKQSKIXZRQO-UHFFFAOYSA-N	765404	US12391697, Example 28	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765404&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319476	520666859							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711947	Cc1cc(-c2ncnn3cc(N4CCO[C@@H](C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H31N7O3/c1-16-10-18(6-7-19(16)12-27-24(34)23-30-25(36-31-23)26(3,4)5)22-21-11-20(14-33(21)29-15-28-22)32-8-9-35-17(2)13-32/h6-7,10-11,14-15,17H,8-9,12-13H2,1-5H3,(H,27,34)	TVCHVSHWIHRHKU-UHFFFAOYSA-N	765405	tert-butyl (2-methyl-4-(6-(2-methylmorpholino)pyrrolo[2,1-f][1,2,4]triazin-4-yl)benzyl)carbamate::US12391697, Example 29	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765405&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319142	520666860							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711948	Cc1cc(-c2ncnn3cc(N4CCO[C@H](C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H31N7O3/c1-16-10-18(6-7-19(16)12-27-24(34)23-30-25(36-31-23)26(3,4)5)22-21-11-20(14-33(21)29-15-28-22)32-8-9-35-17(2)13-32/h6-7,10-11,14-15,17H,8-9,12-13H2,1-5H3,(H,27,34)	TVCHVSHWIHRHKU-UHFFFAOYSA-N	765406	US12391697, Example 30	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765406&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319092	520666861							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711949	Cc1c([C@@H](C)NC(=O)c2noc(C(C)(C)C)n2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C26H30FN7O3/c1-15-18(16(2)30-24(35)23-31-25(37-32-23)26(3,4)5)6-7-19(21(15)27)22-20-12-17(13-34(20)29-14-28-22)33-8-10-36-11-9-33/h6-7,12-14,16H,8-11H2,1-5H3,(H,30,35)	SDIQSYBQVROQKK-UHFFFAOYSA-N	765407	US12391697, Example 31	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765407&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319049	520666862							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711950	Cc1cc(-c2ncnn3cc(N4CCN(C5COC5)CC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C28H34N8O3/c1-18-11-19(5-6-20(18)13-29-26(37)25-32-27(39-33-25)28(2,3)4)24-23-12-21(14-36(23)31-17-30-24)34-7-9-35(10-8-34)22-15-38-16-22/h5-6,11-12,14,17,22H,7-10,13,15-16H2,1-4H3,(H,29,37)	AXQNBJYIMONQDL-UHFFFAOYSA-N	765408	US12391697, Example 32	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765408&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319173	520666863							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711951	Cc1c(CNC(=O)c2noc(C(C)(C)CF)n2)ccc(-c2ncnn3cc(-c4cnn(C)c4)cc23)c1F	InChI=1S/C25H24F2N8O2/c1-14-15(8-28-23(36)22-32-24(37-33-22)25(2,3)12-26)5-6-18(20(14)27)21-19-7-16(11-35(19)31-13-29-21)17-9-30-34(4)10-17/h5-7,9-11,13H,8,12H2,1-4H3,(H,28,36)	XHINDBFQHGJBRY-UHFFFAOYSA-N	765409	US12391697, Example 33	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765409&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319520	520666864							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711952	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C(F)(F)F)no1	InChI=1S/C25H26F3N7O3/c1-24(2,3)23-32-21(33-38-23)22(36)29-12-16-5-4-15(10-18(16)25(26,27)28)20-19-11-17(13-35(19)31-14-30-20)34-6-8-37-9-7-34/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H,29,36)	RANRIZQJPYEBGC-UHFFFAOYSA-N	765410	US12391697, Example 34	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765410	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765410&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319086	520666865							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711953	COc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H26N8O3/c1-25(2,3)24-30-22(31-36-24)23(34)26-10-16-7-6-15(9-20(16)35-5)21-19-8-17(13-33(19)29-14-27-21)18-11-28-32(4)12-18/h6-9,11-14H,10H2,1-5H3,(H,26,34)	VDEZWPLMYWKJBM-UHFFFAOYSA-N	765411	US12391697, Example 35	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765411&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319344	520666866							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711954	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C(F)F)c4F)ncnn3c2)cn1	InChI=1S/C25H23F3N8O2/c1-25(2,3)24-33-22(34-38-24)23(37)29-8-13-5-6-16(19(26)18(13)21(27)28)20-17-7-14(11-36(17)32-12-30-20)15-9-31-35(4)10-15/h5-7,9-12,21H,8H2,1-4H3,(H,29,37)	AMMRNKCMDAZILL-UHFFFAOYSA-N	765412	US12391697, Example 36	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765412&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319015	520666867							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711955	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C2CC2)no1	InChI=1S/C27H31N7O3/c1-27(2,3)26-31-24(32-37-26)25(35)28-14-19-7-6-18(12-21(19)17-4-5-17)23-22-13-20(15-34(22)30-16-29-23)33-8-10-36-11-9-33/h6-7,12-13,15-17H,4-5,8-11,14H2,1-3H3,(H,28,35)	IVLFETGSWGZKHE-UHFFFAOYSA-N	765413	US12391697, Example 37	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765413&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319242	520666868							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711956	Cc1cc(-c2ncnn3cc(-c4ccncc4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H25N7O2/c1-16-11-18(5-6-19(16)13-28-24(34)23-31-25(35-32-23)26(2,3)4)22-21-12-20(14-33(21)30-15-29-22)17-7-9-27-10-8-17/h5-12,14-15H,13H2,1-4H3,(H,28,34)	WWSLSSPJDCORDS-UHFFFAOYSA-N	765414	US12391697, Example 38	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765414&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319578	520666869							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711957	Cc1cc(-c2ncnn3cc(N4C[C@@H](C)O[C@@H](C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H33N7O3/c1-16-9-19(7-8-20(16)11-28-25(35)24-31-26(37-32-24)27(4,5)6)23-22-10-21(14-34(22)30-15-29-23)33-12-17(2)36-18(3)13-33/h7-10,14-15,17-18H,11-13H2,1-6H3,(H,28,35)	IBARQTNPWXUWFK-UHFFFAOYSA-N	765415	US12391697, Example 39	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765415	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765415&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156345530	520666870							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711958	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1noc(C2(C)CC2)n1	InChI=1S/C25H24N8O2/c1-15-8-16(21-20-9-18(13-33(20)29-14-27-21)19-11-28-32(3)12-19)4-5-17(15)10-26-23(34)22-30-24(35-31-22)25(2)6-7-25/h4-5,8-9,11-14H,6-7,10H2,1-3H3,(H,26,34)	ZKWOODYQPUNRBP-UHFFFAOYSA-N	765416	US12391697, Example 40	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765416&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319107	520666871							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711959	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1noc(C(C)(C)CF)n1	InChI=1S/C25H25FN8O2/c1-15-7-16(21-20-8-18(12-34(20)30-14-28-21)19-10-29-33(4)11-19)5-6-17(15)9-27-23(35)22-31-24(36-32-22)25(2,3)13-26/h5-8,10-12,14H,9,13H2,1-4H3,(H,27,35)	CBVLJUNTJWVIBA-UHFFFAOYSA-N	765417	US12391697, Example 41	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765417&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319591	520666872							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711960	Cc1c(CNC(=O)c2noc(C3(C)CC3)n2)ccc(-c2ncnn3cc(-c4cnn(C)c4)cc23)c1F	InChI=1S/C25H23FN8O2/c1-14-15(9-27-23(35)22-31-24(36-32-22)25(2)6-7-25)4-5-18(20(14)26)21-19-8-16(12-34(19)30-13-28-21)17-10-29-33(3)11-17/h4-5,8,10-13H,6-7,9H2,1-3H3,(H,27,35)	AIJJRKJCIHEFBZ-UHFFFAOYSA-N	765418	US12391697, Example 42	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765418&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319440	520666873							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711961	Cc1cc(-c2ncnn3cc(N4C[C@@H](C)O[C@H](C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H33N7O3/c1-16-9-19(7-8-20(16)11-28-25(35)24-31-26(37-32-24)27(4,5)6)23-22-10-21(14-34(22)30-15-29-23)33-12-17(2)36-18(3)13-33/h7-10,14-15,17-18H,11-13H2,1-6H3,(H,28,35)	IBARQTNPWXUWFK-UHFFFAOYSA-N	765419	hydrochloride::US12391697, Example 43	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765419&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319308	520666874							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711962	Cc1cc(-c2ncnn3cc(N4C[C@H](C)O[C@@H](C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H33N7O3/c1-16-9-19(7-8-20(16)11-28-25(35)24-31-26(37-32-24)27(4,5)6)23-22-10-21(14-34(22)30-15-29-23)33-12-17(2)36-18(3)13-33/h7-10,14-15,17-18H,11-13H2,1-6H3,(H,28,35)	IBARQTNPWXUWFK-UHFFFAOYSA-N	765420	US12391697, Example 44	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765420&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319443	520666875							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711963	COc1c(CNC(=O)c2nc(C(C)(C)C)no2)ccc(-c2ncnn3cc(-c4cnn(C)c4)cc23)c1F	InChI=1S/C25H25FN8O3/c1-25(2,3)24-31-23(37-32-24)22(35)27-9-14-6-7-17(19(26)21(14)36-5)20-18-8-15(12-34(18)30-13-28-20)16-10-29-33(4)11-16/h6-8,10-13H,9H2,1-5H3,(H,27,35)	LGSMKCQCMVTCAK-UHFFFAOYSA-N	765421	US12391697, Example 45	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765421&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319196	520666876							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711964	Cc1cc2nccc(-c3ccc(CNC(=O)c4noc(C(C)(C)C)n4)c(C)c3)n2n1	InChI=1S/C22H24N6O2/c1-13-10-15(17-8-9-23-18-11-14(2)26-28(17)18)6-7-16(13)12-24-20(29)19-25-21(30-27-19)22(3,4)5/h6-11H,12H2,1-5H3,(H,24,29)	TZKSSEZFDNKJMG-UHFFFAOYSA-N	765422	US12391697, Example 46	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765422&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319063	520666877							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711965	Cc1cc(-c2ccnn3cnnc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C20H21N7O2/c1-12-9-13(15-7-8-23-27-11-22-25-17(15)27)5-6-14(12)10-21-18(28)16-24-19(29-26-16)20(2,3)4/h5-9,11H,10H2,1-4H3,(H,21,28)	GTCLTAXIQGMXMM-UHFFFAOYSA-N	765423	US12391697, Example 47	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765423&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319428	520666878							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711966	Cc1cc(-c2ncnn3cnc(C)c23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C21H23N7O2/c1-12-8-14(16-17-13(2)24-11-28(17)25-10-23-16)6-7-15(12)9-22-19(29)18-26-20(30-27-18)21(3,4)5/h6-8,10-11H,9H2,1-5H3,(H,22,29)	JTGMOYCLHJYTCV-UHFFFAOYSA-N	765424	US12391697, Example 48	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765424&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319623	520666879							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711967	Cc1cc(-c2ncnn3ccc(C)c23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C22H24N6O2/c1-13-8-9-28-18(13)17(24-12-25-28)15-6-7-16(14(2)10-15)11-23-20(29)19-26-21(30-27-19)22(3,4)5/h6-10,12H,11H2,1-5H3,(H,23,29)	NGSIQLPDQXWQOA-UHFFFAOYSA-N	765425	US12391697, Example 49	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765425&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319099	520666880							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711968	Cc1cc(-c2ccnc3ccnn23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C21H22N6O2/c1-13-11-14(16-7-9-22-17-8-10-24-27(16)17)5-6-15(13)12-23-19(28)18-25-20(29-26-18)21(2,3)4/h5-11H,12H2,1-4H3,(H,23,28)	SBKTXWSEQJEYET-UHFFFAOYSA-N	765426	US12391697, Example 50	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765426&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318997	520666881							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711969	Cc1cc(-c2ncnn3cc(Br)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C21H21BrN6O2/c1-12-7-13(17-16-8-15(22)10-28(16)25-11-24-17)5-6-14(12)9-23-19(29)18-26-20(30-27-18)21(2,3)4/h5-8,10-11H,9H2,1-4H3,(H,23,29)	IWTFOBBHKCJRHG-UHFFFAOYSA-N	765427	US12391697, Example 51	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765427&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319200	520666882							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711970	Cc1cc(-c2ncnn3ccnc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C20H21N7O2/c1-12-9-13(15-17-21-7-8-27(17)24-11-23-15)5-6-14(12)10-22-18(28)16-25-19(29-26-16)20(2,3)4/h5-9,11H,10H2,1-4H3,(H,22,28)	IQKRPGMETAPFGX-UHFFFAOYSA-N	765428	US12391697, Example 52	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765428&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319464	520666883							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711971	Cc1cc(-c2c(C#N)cnn3cccc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C23H22N6O2/c1-14-10-15(19-17(11-24)13-26-29-9-5-6-18(19)29)7-8-16(14)12-25-21(30)20-27-22(31-28-20)23(2,3)4/h5-10,13H,12H2,1-4H3,(H,25,30)	KZTHGBOXWSGUHD-UHFFFAOYSA-N	765429	US12391697, Example 53	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765429&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319149	520666884							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711972	Cc1cc(-c2ncnn3cncc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C20H21N7O2/c1-12-7-13(16-15-9-21-11-27(15)24-10-23-16)5-6-14(12)8-22-18(28)17-25-19(29-26-17)20(2,3)4/h5-7,9-11H,8H2,1-4H3,(H,22,28)	CBIDSDNQEVCHDY-UHFFFAOYSA-N	765430	US12391697, Example 54	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765430&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318977	520666885							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711973	Cc1cc2c(-c3ccc(CNC(=O)c4noc(C(C)(C)C)n4)c(C)c3)ncnn2c1	InChI=1S/C22H24N6O2/c1-13-8-17-18(24-12-25-28(17)11-13)15-6-7-16(14(2)9-15)10-23-20(29)19-26-21(30-27-19)22(3,4)5/h6-9,11-12H,10H2,1-5H3,(H,23,29)	XDNQEONWNQSAKA-UHFFFAOYSA-N	765431	US12391697, Example 55	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765431&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319577	520666886							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711974	CC(C)(C)c1nc(C(=O)N[C@@H]2CCCCc3c2ccc(-c2ncnn4cccc24)c3F)no1	InChI=1S/C24H25FN6O2/c1-24(2,3)23-29-21(30-33-23)22(32)28-17-8-5-4-7-15-14(17)10-11-16(19(15)25)20-18-9-6-12-31(18)27-13-26-20/h6,9-13,17H,4-5,7-8H2,1-3H3,(H,28,32)	YWLLZFWBYLKYBM-UHFFFAOYSA-N	765432	US12391697, Example 56	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765432&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319074	520666887							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711975	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1[C@@H](C)NC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C26H28N8O2/c1-15-9-17(22-21-10-18(13-34(21)29-14-27-22)19-11-28-33(6)12-19)7-8-20(15)16(2)30-23(35)24-31-25(32-36-24)26(3,4)5/h7-14,16H,1-6H3,(H,30,35)	BXGYULLCLDJYCD-UHFFFAOYSA-N	765433	US12391697, Example 57	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765433&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319433	520666888							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711976	COCCOc1cc2c(-c3ccc(CNC(=O)c4noc(C(C)(C)C)n4)c(C)c3)ncnn2c1	InChI=1S/C24H28N6O4/c1-15-10-16(20-19-11-18(33-9-8-32-5)13-30(19)27-14-26-20)6-7-17(15)12-25-22(31)21-28-23(34-29-21)24(2,3)4/h6-7,10-11,13-14H,8-9,12H2,1-5H3,(H,25,31)	MLGBDWHZQQYXHK-UHFFFAOYSA-N	765434	US12391697, Example 58	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765434&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318979	520666889							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711977	C=CC(=O)n1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C)c4)ncnn3c2)cn1	InChI=1S/C27H26N8O3/c1-6-22(36)35-14-20(12-30-35)19-10-21-23(29-15-31-34(21)13-19)17-7-8-18(16(2)9-17)11-28-25(37)24-32-26(38-33-24)27(3,4)5/h6-10,12-15H,1,11H2,2-5H3,(H,28,37)	NHVHDFVTKUAZRS-UHFFFAOYSA-N	765435	US12391697, Example 59	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765435&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319322	520666890							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711978	Cc1cc(-c2ncnn3cc(C4CN(C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H29N7O2/c1-15-8-16(21-20-9-18(19-11-31(5)12-19)13-32(20)28-14-27-21)6-7-17(15)10-26-23(33)22-29-24(34-30-22)25(2,3)4/h6-9,13-14,19H,10-12H2,1-5H3,(H,26,33)	PILCKKFLWWRPRR-UHFFFAOYSA-N	765436	US12391697, Example 60	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765436&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319190	520666891							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711979	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5cnn(C(C)(C)C)c5)c(C(F)(F)F)c4)ncnn3c2)cn1	InChI=1S/C26H25F3N8O/c1-25(2,3)37-14-20(11-33-37)24(38)30-9-17-6-5-16(7-21(17)26(27,28)29)23-22-8-18(13-36(22)34-15-31-23)19-10-32-35(4)12-19/h5-8,10-15H,9H2,1-4H3,(H,30,38)	QGGRDCVYUFJVIH-UHFFFAOYSA-N	765437	US12391697, Example 61	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765437&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319141	520666892							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711980	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cccc34)c(F)c2C2CC2)no1	InChI=1S/C23H23FN6O2/c1-23(2,3)22-28-20(29-32-22)21(31)25-11-14-8-9-15(18(24)17(14)13-6-7-13)19-16-5-4-10-30(16)27-12-26-19/h4-5,8-10,12-13H,6-7,11H2,1-3H3,(H,25,31)	WOKDJJBRFNMDBX-UHFFFAOYSA-N	765438	US12391697, Example 62	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765438&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319335	520666893							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711981	Cc1c(CNC(=O)c2noc(C(C)(C)C)n2)cc(F)c(-c2ncnn3cccc23)c1F	InChI=1S/C21H20F2N6O2/c1-11-12(9-24-19(30)18-27-20(31-28-18)21(2,3)4)8-13(22)15(16(11)23)17-14-6-5-7-29(14)26-10-25-17/h5-8,10H,9H2,1-4H3,(H,24,30)	ORFOCOOGOKCTOE-UHFFFAOYSA-N	765439	US12391697, Example 63	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765439&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319124	520666894							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711982	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5cn(C(C)(C)C)nn5)c(C(F)F)c4)ncnn3c2)cn1	InChI=1S/C25H25F2N9O/c1-25(2,3)36-13-20(32-33-36)24(37)28-9-16-6-5-15(7-19(16)23(26)27)22-21-8-17(12-35(21)31-14-29-22)18-10-30-34(4)11-18/h5-8,10-14,23H,9H2,1-4H3,(H,28,37)	XRNBUVKVLMMCGO-UHFFFAOYSA-N	765440	US12391697, Example 64	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765440&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319053	520666895							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711983	CC(C)(C)c1noc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2CC(F)F)n1	InChI=1S/C26H29F2N7O3/c1-26(2,3)25-32-24(38-33-25)23(36)29-13-17-5-4-16(10-18(17)11-21(27)28)22-20-12-19(14-35(20)31-15-30-22)34-6-8-37-9-7-34/h4-5,10,12,14-15,21H,6-9,11,13H2,1-3H3,(H,29,36)	YLCHCXRURJFLRF-UHFFFAOYSA-N	765441	US12391697, Example 65	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765441&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319150	520666896							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711984	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(CC(F)F)c4F)ncnn3c2)cn1	InChI=1S/C26H25F3N8O2/c1-26(2,3)25-34-24(39-35-25)23(38)30-9-14-5-6-17(21(29)18(14)8-20(27)28)22-19-7-15(12-37(19)33-13-31-22)16-10-32-36(4)11-16/h5-7,10-13,20H,8-9H2,1-4H3,(H,30,38)	JCMWDNMOHBJALI-UHFFFAOYSA-N	765442	US12391697, Example 66	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765442&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319183	520666897							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711985	Cc1cc(-c2ncnn3cc(C(=O)N(C)C)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C24H27N7O3/c1-14-9-15(19-18-10-17(22(33)30(5)6)12-31(18)27-13-26-19)7-8-16(14)11-25-21(32)20-28-23(34-29-20)24(2,3)4/h7-10,12-13H,11H2,1-6H3,(H,25,32)	OFMRMGXELJHDAN-UHFFFAOYSA-N	765443	US12391697, Example 67	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765443&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319126	520666898							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711986	Cc1cc(-c2ncnn3cc(-c4ncccn4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H24N8O2/c1-15-10-16(6-7-17(15)12-28-23(34)22-31-24(35-32-22)25(2,3)4)20-19-11-18(13-33(19)30-14-29-20)21-26-8-5-9-27-21/h5-11,13-14H,12H2,1-4H3,(H,28,34)	KNBYCXAEMSRBFU-UHFFFAOYSA-N	765444	US12391697, Example 68	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765444&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318933	520666899							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711987	Cc1cc(-c2ncnn3cc(N4CCN(C)CC4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C26H32N8O2/c1-17-12-18(6-7-19(17)14-27-23(35)24-30-25(31-36-24)26(2,3)4)22-21-13-20(15-34(21)29-16-28-22)33-10-8-32(5)9-11-33/h6-7,12-13,15-16H,8-11,14H2,1-5H3,(H,27,35)	VUYHVKKHDJKNSM-UHFFFAOYSA-N	765445	US12391697, Example 69	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765445&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319402	520666900							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711988	Cc1cc(-c2ncnn3cc(N4CCN(C)C[C@H]4C)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H34N8O2/c1-17-11-19(7-8-20(17)13-28-25(36)24-31-26(37-32-24)27(3,4)5)23-22-12-21(15-35(22)30-16-29-23)34-10-9-33(6)14-18(34)2/h7-8,11-12,15-16,18H,9-10,13-14H2,1-6H3,(H,28,36)	WGCCJDGDHGVDFI-UHFFFAOYSA-N	765446	US12391697, Example 70	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765446&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319450	520666901							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711989	Cc1cc(-c2ncnn3cc(C4COC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C24H26N6O3/c1-14-7-15(20-19-8-17(18-11-32-12-18)10-30(19)27-13-26-20)5-6-16(14)9-25-22(31)21-28-23(33-29-21)24(2,3)4/h5-8,10,13,18H,9,11-12H2,1-4H3,(H,25,31)	XLQRPAXIJFCVNB-UHFFFAOYSA-N	765447	US12391697, Example 71	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765447&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318929	520666902							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711990	Cc1cc(-c2ncnn3cc(C4CCOCC4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C26H30N6O3/c1-16-11-18(5-6-19(16)13-27-23(33)24-30-25(31-35-24)26(2,3)4)22-21-12-20(14-32(21)29-15-28-22)17-7-9-34-10-8-17/h5-6,11-12,14-15,17H,7-10,13H2,1-4H3,(H,27,33)	VDKWOYOBHUPDEG-UHFFFAOYSA-N	765448	US12391697, Example 72	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765448&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319019	520666903							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711991	Cc1cc(-c2ncnn3cc(N4CC(CO)(CO)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H31N7O4/c1-16-7-17(5-6-18(16)9-27-23(36)22-30-24(37-31-22)25(2,3)4)21-20-8-19(10-33(20)29-15-28-21)32-11-26(12-32,13-34)14-35/h5-8,10,15,34-35H,9,11-14H2,1-4H3,(H,27,36)	PQTXTAHKCGXLAS-UHFFFAOYSA-N	765449	US12391697, Example 73	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765449&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318916	520666904							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711992	Cc1cc(-c2ncnn3cc(C4CC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C24H26N6O2/c1-14-9-16(20-19-10-18(15-5-6-15)12-30(19)27-13-26-20)7-8-17(14)11-25-22(31)21-28-23(32-29-21)24(2,3)4/h7-10,12-13,15H,5-6,11H2,1-4H3,(H,25,31)	AQRGMVVIBHQASC-UHFFFAOYSA-N	765450	US12391697, Example 74	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765450&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319483	520666905							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711993	Cc1cc(-c2ncnn3cc(N4CCN(C5COC5)C[C@@H]4C)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C29H36N8O3/c1-18-10-20(6-7-21(18)12-30-27(38)26-33-28(40-34-26)29(3,4)5)25-24-11-22(14-37(24)32-17-31-25)36-9-8-35(13-19(36)2)23-15-39-16-23/h6-7,10-11,14,17,19,23H,8-9,12-13,15-16H2,1-5H3,(H,30,38)	SXDRDQSQARJKPP-UHFFFAOYSA-N	765451	US12391697, Example 75	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765451&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319226	520666906							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711994	C#Cc1cc2c(-c3ccc(CNC(=O)c4noc(C(C)(C)C)n4)c(C)c3)ncnn2c1	InChI=1S/C23H22N6O2/c1-6-15-10-18-19(25-13-26-29(18)12-15)16-7-8-17(14(2)9-16)11-24-21(30)20-27-22(31-28-20)23(3,4)5/h1,7-10,12-13H,11H2,2-5H3,(H,24,30)	DYJVQFWJEYXAPX-UHFFFAOYSA-N	765452	US12391697, Example 76	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765452&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319197	520666907							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711995	COCc1cc2c(-c3ccc(CNC(=O)c4noc(C(C)(C)C)n4)c(C)c3)ncnn2c1	InChI=1S/C23H26N6O3/c1-14-8-16(19-18-9-15(12-31-5)11-29(18)26-13-25-19)6-7-17(14)10-24-21(30)20-27-22(32-28-20)23(2,3)4/h6-9,11,13H,10,12H2,1-5H3,(H,24,30)	PCUHUKIQCNKLFZ-UHFFFAOYSA-N	765453	US12391697, Example 77	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765453&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319195	520666908							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711996	Cc1cc(-c2ncnn3cc(N4CCOC(C)(C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H33N7O3/c1-17-11-18(7-8-19(17)13-28-24(35)23-31-25(37-32-23)26(2,3)4)22-21-12-20(14-34(21)30-16-29-22)33-9-10-36-27(5,6)15-33/h7-8,11-12,14,16H,9-10,13,15H2,1-6H3,(H,28,35)	ISGZSXBBGHCRQC-UHFFFAOYSA-N	765454	US12391697, Example 78	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765454&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319415	520666909							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711997	Cc1cc(-c2ncnn3cc(OC4CCOCC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H30N6O4/c1-16-11-17(5-6-18(16)13-27-24(33)23-30-25(36-31-23)26(2,3)4)22-21-12-20(14-32(21)29-15-28-22)35-19-7-9-34-10-8-19/h5-6,11-12,14-15,19H,7-10,13H2,1-4H3,(H,27,33)	HCGXYCLMIVQZSY-UHFFFAOYSA-N	765455	US12391697, Example 79	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765455&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319193	520666910							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711998	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H26N8O2/c1-15-8-16(6-7-17(15)10-26-23(34)22-30-24(35-31-22)25(2,3)4)21-20-9-18(13-33(20)29-14-27-21)19-11-28-32(5)12-19/h6-9,11-14H,10H2,1-5H3,(H,26,34)	NXWLETKLDQJIDN-UHFFFAOYSA-N	765456	US12391697, Example 80	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765456&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319427	520666911							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
711999	Cc1c(CNC(=O)c2nnc(C(C)(C)C)o2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C25H28FN7O3/c1-15-16(12-27-22(34)23-30-31-24(36-23)25(2,3)4)5-6-18(20(15)26)21-19-11-17(13-33(19)29-14-28-21)32-7-9-35-10-8-32/h5-6,11,13-14H,7-10,12H2,1-4H3,(H,27,34)	DCFFCUXAGBYMHW-UHFFFAOYSA-N	765457	US12391697, Example 81	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765457&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319340	520666912							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712000	Cc1c(CNC(=O)c2noc(C(C)(C)C)n2)ccc(-c2ncnc3cc(-c4cnn(C)c4)nn23)c1F	InChI=1S/C24H24FN9O2/c1-13-14(9-26-22(35)20-30-23(36-32-20)24(2,3)4)6-7-16(19(13)25)21-28-12-27-18-8-17(31-34(18)21)15-10-29-33(5)11-15/h6-8,10-12H,9H2,1-5H3,(H,26,35)	VOAJPYWRNMCSHJ-UHFFFAOYSA-N	765458	US12391697, Example 82	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765458&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			167327327	520666913							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712001	Cc1c(CNC(=O)c2nc(C(C)(C)C)no2)ccc(-c2ccnc3cc(-c4cnn(C)c4)nn23)c1F	InChI=1S/C25H25FN8O2/c1-14-15(11-28-22(35)23-30-24(32-36-23)25(2,3)4)6-7-17(21(14)26)19-8-9-27-20-10-18(31-34(19)20)16-12-29-33(5)13-16/h6-10,12-13H,11H2,1-5H3,(H,28,35)	QHGJLNZGDCSCDY-UHFFFAOYSA-N	765459	US12391697, Example 83	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765459&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319113	520666914							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712002	Cc1c(CNC(=O)c2noc(C(C)(C)C)n2)ccc(-c2ccnc3cc(N4CCOCC4)nn23)c1F	InChI=1S/C25H28FN7O3/c1-15-16(14-28-23(34)22-29-24(36-31-22)25(2,3)4)5-6-17(21(15)26)18-7-8-27-19-13-20(30-33(18)19)32-9-11-35-12-10-32/h5-8,13H,9-12,14H2,1-4H3,(H,28,34)	CCPVPKORGLIKSC-UHFFFAOYSA-N	765460	US12391697, Example 84	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765460&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319410	520666915							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712003	Cc1cc(-c2ncnn3cc(-c4cn[nH]c4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C24H24N8O2/c1-14-7-15(20-19-8-17(18-10-27-28-11-18)12-32(19)29-13-26-20)5-6-16(14)9-25-22(33)21-30-23(34-31-21)24(2,3)4/h5-8,10-13H,9H2,1-4H3,(H,25,33)(H,27,28)	UMEVUYBLDPKONP-UHFFFAOYSA-N	765461	US12391697, Example 85	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765461&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319429	520666916							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712004	Cc1c(CNC(=O)c2noc(C(C)(C)C)n2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C25H28FN7O3/c1-15-16(12-27-23(34)22-30-24(36-31-22)25(2,3)4)5-6-18(20(15)26)21-19-11-17(13-33(19)29-14-28-21)32-7-9-35-10-8-32/h5-6,11,13-14H,7-10,12H2,1-4H3,(H,27,34)	KUVKBDHEUAKQSS-UHFFFAOYSA-N	765462	US12391697, Example 86	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765462&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319048	520666917							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712005	Cc1c(CNC(=O)c2cn(C(C)(C)C)nn2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C25H29FN8O2/c1-16-17(12-27-24(35)20-14-34(31-30-20)25(2,3)4)5-6-19(22(16)26)23-21-11-18(13-33(21)29-15-28-23)32-7-9-36-10-8-32/h5-6,11,13-15H,7-10,12H2,1-4H3,(H,27,35)	QPTSCDWGQKBGNO-UHFFFAOYSA-N	765463	US12391697, Example 87	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765463&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318985	520666918							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712006	Cc1c(CNC(=O)c2cnn(C(C)(C)C)c2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C26H30FN7O2/c1-17-18(12-28-25(35)19-13-30-34(14-19)26(2,3)4)5-6-21(23(17)27)24-22-11-20(15-33(22)31-16-29-24)32-7-9-36-10-8-32/h5-6,11,13-16H,7-10,12H2,1-4H3,(H,28,35)	LNNFFIOGASHLQC-UHFFFAOYSA-N	765464	US12391697, Example 88	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765464&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319096	520666919							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712007	Cc1c(CNC(=O)c2ccn(C(C)(C)C)n2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C26H30FN7O2/c1-17-18(14-28-25(35)21-7-8-34(31-21)26(2,3)4)5-6-20(23(17)27)24-22-13-19(15-33(22)30-16-29-24)32-9-11-36-12-10-32/h5-8,13,15-16H,9-12,14H2,1-4H3,(H,28,35)	WHVXKNUVUYGQHI-UHFFFAOYSA-N	765465	US12391697, Example 89	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765465&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319295	520666920							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712008	Cc1cc(-c2ncnn3cc(N4CCN(C)C[C@H]4C)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H34N8O2/c1-17-11-19(7-8-20(17)13-28-25(36)24-31-26(37-32-24)27(3,4)5)23-22-12-21(15-35(22)30-16-29-23)34-10-9-33(6)14-18(34)2/h7-8,11-12,15-16,18H,9-10,13-14H2,1-6H3,(H,28,36)	WGCCJDGDHGVDFI-UHFFFAOYSA-N	765466	US12391697, Example 92	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765466&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319450	520666921							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712009	Cc1cc(-c2ncnn3cc(N4C[C@@H]5C[C@H]4CN5C)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H32N8O2/c1-16-8-17(6-7-18(16)11-28-25(36)24-31-26(37-32-24)27(2,3)4)23-22-10-21(14-35(22)30-15-29-23)34-13-19-9-20(34)12-33(19)5/h6-8,10,14-15,19-20H,9,11-13H2,1-5H3,(H,28,36)	FZHGJZOXOBTEOQ-UHFFFAOYSA-N	765467	US12391697, Example 93	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765467&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319500	520666922							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712010	Cc1cc(-c2ncnn3cc(CC4CCOCC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H32N6O3/c1-17-11-20(5-6-21(17)14-28-25(34)24-31-26(36-32-24)27(2,3)4)23-22-13-19(15-33(22)30-16-29-23)12-18-7-9-35-10-8-18/h5-6,11,13,15-16,18H,7-10,12,14H2,1-4H3,(H,28,34)	FPAXUKORTWGOGD-UHFFFAOYSA-N	765468	US12391697, Example 94	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765468&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319233	520666923							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712011	Cc1cc(-c2ncnn3cc(C4CCOC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H28N6O3/c1-15-9-16(21-20-10-19(18-7-8-33-13-18)12-31(20)28-14-27-21)5-6-17(15)11-26-23(32)22-29-24(34-30-22)25(2,3)4/h5-6,9-10,12,14,18H,7-8,11,13H2,1-4H3,(H,26,32)	UVJLGHBNULRRMN-UHFFFAOYSA-N	765469	US12391697, Example 95	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765469&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319268	520666924							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712012	Cc1cc(-c2ncnn3cc(N4CCN(C)C(C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H34N8O2/c1-17-11-19(7-8-20(17)13-28-25(36)24-31-26(37-32-24)27(3,4)5)23-22-12-21(15-35(22)30-16-29-23)34-10-9-33(6)18(2)14-34/h7-8,11-12,15-16,18H,9-10,13-14H2,1-6H3,(H,28,36)	AVECFRLWSNRVBV-UHFFFAOYSA-N	765470	US12391697, Example 96	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765470&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319279	520666925							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712013	COC1CCN(c2cc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(C)c4)ncnn3c2)CC1	InChI=1S/C27H33N7O3/c1-17-12-18(6-7-19(17)14-28-24(35)25-31-26(32-37-25)27(2,3)4)23-22-13-20(15-34(22)30-16-29-23)33-10-8-21(36-5)9-11-33/h6-7,12-13,15-16,21H,8-11,14H2,1-5H3,(H,28,35)	ONBFSMLVAZDMCK-UHFFFAOYSA-N	765471	US12391697, Example 97	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765471&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319055	520666926							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712014	Cc1cc(-c2ncnn3cc(N4CCN(C)C(C)C4)cc23)ccc1CNC(=O)c1nnn(C(C)(C)C)n1	InChI=1S/C26H34N10O/c1-17-11-19(7-8-20(17)13-27-25(37)24-30-32-36(31-24)26(3,4)5)23-22-12-21(15-35(22)29-16-28-23)34-10-9-33(6)18(2)14-34/h7-8,11-12,15-16,18H,9-10,13-14H2,1-6H3,(H,27,37)	QLIWWNIOORFMEX-UHFFFAOYSA-N	765472	US12391697, Example 98	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765472&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319028	520666927							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712015	COC1CN(c2cc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(C)c4)ncnn3c2)CC1C	InChI=1S/C27H33N7O3/c1-16-9-18(7-8-19(16)11-28-24(35)25-31-26(32-37-25)27(3,4)5)23-21-10-20(13-34(21)30-15-29-23)33-12-17(2)22(14-33)36-6/h7-10,13,15,17,22H,11-12,14H2,1-6H3,(H,28,35)	PWPBNUVZZHWZJD-UHFFFAOYSA-N	765473	US12391697, Example 99	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765473&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			177691981	520666928							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712016	Cc1cc(-c2ncnn3cc(N4CCOC(C(C)C)C4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C28H35N7O3/c1-17(2)23-15-34(9-10-37-23)21-12-22-24(30-16-31-35(22)14-21)19-7-8-20(18(3)11-19)13-29-25(36)26-32-27(33-38-26)28(4,5)6/h7-8,11-12,14,16-17,23H,9-10,13,15H2,1-6H3,(H,29,36)	KWUMJCAVTVJMKE-UHFFFAOYSA-N	765474	US12391697, Example 100	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765474&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319383	520666929							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712017	Cc1cc(-c2ncnn3cc(C4=CCSCC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H28N6O2S/c1-16-11-18(5-6-19(16)13-27-24(33)23-30-25(34-31-23)26(2,3)4)22-21-12-20(14-32(21)29-15-28-22)17-7-9-35-10-8-17/h5-7,11-12,14-15H,8-10,13H2,1-4H3,(H,27,33)	DJDRUBFIBJEGMU-UHFFFAOYSA-N	765475	US12391697, Example 101	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765475&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319453	520666930							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712018	Cc1cc(-c2ncnn3cc(C#N)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C22H21N7O2/c1-13-7-15(18-17-8-14(9-23)11-29(17)26-12-25-18)5-6-16(13)10-24-20(30)19-27-21(31-28-19)22(2,3)4/h5-8,11-12H,10H2,1-4H3,(H,24,30)	ISTCSQRQMFJIMZ-UHFFFAOYSA-N	765476	US12391697, Example 102	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765476&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319622	520666931							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712019	Cc1cc(-c2ncnn3cc(C4=CCOCC4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C26H28N6O3/c1-16-11-18(5-6-19(16)13-27-23(33)24-30-25(31-35-24)26(2,3)4)22-21-12-20(14-32(21)29-15-28-22)17-7-9-34-10-8-17/h5-7,11-12,14-15H,8-10,13H2,1-4H3,(H,27,33)	YIWFHXNKBLWPQS-UHFFFAOYSA-N	765477	US12391697, Example 103	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765477&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319130	520666932							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712020	Cc1cc(-c2ncnn3cc(-c4cnn(C5COC5)c4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H28N8O3/c1-16-7-17(5-6-18(16)9-28-25(36)24-32-26(38-33-24)27(2,3)4)23-22-8-19(11-35(22)31-15-29-23)20-10-30-34(12-20)21-13-37-14-21/h5-8,10-12,15,21H,9,13-14H2,1-4H3,(H,28,36)	NYKKCLLTSFISKW-UHFFFAOYSA-N	765478	US12391697, Example 104	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765478&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319261	520666933							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712021	Cc1cc(-c2ncnn3cc(N4CCOCC4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C25H29N7O3/c1-16-11-17(5-6-18(16)13-26-22(33)23-29-24(30-35-23)25(2,3)4)21-20-12-19(14-32(20)28-15-27-21)31-7-9-34-10-8-31/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,33)	PNPOJXDCFOALDM-UHFFFAOYSA-N	765479	US12391697, Example 105	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765479&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319129	520666934							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712022	Cc1cc(-c2ncnn3cc(-c4cn(C)nn4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C24H25N9O2/c1-14-8-15(6-7-16(14)10-25-22(34)21-28-23(35-30-21)24(2,3)4)20-19-9-17(11-33(19)27-13-26-20)18-12-32(5)31-29-18/h6-9,11-13H,10H2,1-5H3,(H,25,34)	JOAHXUKTCMZUJV-UHFFFAOYSA-N	765480	US12391697, Example 106	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765480&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319324	520666935							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712023	Cc1cc(-c2ncnn3cc(-c4cnn(C(F)F)c4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H24F2N8O2/c1-14-7-15(5-6-16(14)9-28-22(36)21-32-23(37-33-21)25(2,3)4)20-19-8-17(11-34(19)31-13-29-20)18-10-30-35(12-18)24(26)27/h5-8,10-13,24H,9H2,1-4H3,(H,28,36)	KVJFGZSXMILHPD-UHFFFAOYSA-N	765481	US12391697, Example 107	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765481&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319627	520666936							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712024	Cc1cc(-c2ncnn3cc(-c4cn(C)nc4C)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H28N8O2/c1-15-9-17(7-8-18(15)11-27-24(35)23-30-25(36-32-23)26(3,4)5)22-21-10-19(12-34(21)29-14-28-22)20-13-33(6)31-16(20)2/h7-10,12-14H,11H2,1-6H3,(H,27,35)	XCZAIGPGFNKOSX-UHFFFAOYSA-N	765482	US12391697, Example 108	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765482&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319264	520666937							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712025	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4C)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H28N8O2/c1-15-9-17(7-8-18(15)11-27-24(35)23-31-25(36-32-23)26(3,4)5)22-21-10-19(13-34(21)30-14-28-22)20-12-29-33(6)16(20)2/h7-10,12-14H,11H2,1-6H3,(H,27,35)	GZLDJRYLBHRYHL-UHFFFAOYSA-N	765483	US12391697, Example 109	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765483&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319497	520666938							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712026	Cc1cc(-c2ncnn3cc(-c4cnco4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C24H23N7O3/c1-14-7-15(20-18-8-17(19-10-25-13-33-19)11-31(18)28-12-27-20)5-6-16(14)9-26-22(32)21-29-23(34-30-21)24(2,3)4/h5-8,10-13H,9H2,1-4H3,(H,26,32)	JJZAWCJLOLSILI-UHFFFAOYSA-N	765484	US12391697, Example 110	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765484&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319659	520666939							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712027	Cc1cc(-c2ncnn3cc(-c4cn(C)nn4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C24H25N9O2/c1-14-8-15(6-7-16(14)10-25-22(34)21-28-23(35-30-21)24(2,3)4)20-19-9-17(11-33(19)27-13-26-20)18-12-32(5)31-29-18/h6-9,11-13H,10H2,1-5H3,(H,25,34)	JOAHXUKTCMZUJV-UHFFFAOYSA-N	765485	US12391697, Example 111	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765485&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319324	520666940							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712028	Cc1c(CNC(=O)c2noc(C(C)(C)C)n2)ccc(-c2ncnn3cc(-c4cnn(C)c4)cc23)c1F	InChI=1S/C25H25FN8O2/c1-14-15(9-27-23(35)22-31-24(36-32-22)25(2,3)4)6-7-18(20(14)26)21-19-8-16(12-34(19)30-13-28-21)17-10-29-33(5)11-17/h6-8,10-13H,9H2,1-5H3,(H,27,35)	PMGUTJCWKCOROI-UHFFFAOYSA-N	765486	US12391697, Example 112	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765486&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319626	520666941							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712029	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1nnn(C(C)(C)C)n1	InChI=1S/C24H26N10O/c1-15-8-16(6-7-17(15)10-25-23(35)22-29-31-34(30-22)24(2,3)4)21-20-9-18(13-33(20)28-14-26-21)19-11-27-32(5)12-19/h6-9,11-14H,10H2,1-5H3,(H,25,35)	BLWJKNNTUILXTE-UHFFFAOYSA-N	765487	US12391697, Example 113	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765487&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319292	520666942							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712030	Cc1cc(-c2ncnn3cc(N4CCOCC4)cc23)ccc1CNC(=O)c1nnn(C(C)(C)C)n1	InChI=1S/C24H29N9O2/c1-16-11-17(5-6-18(16)13-25-23(34)22-28-30-33(29-22)24(2,3)4)21-20-12-19(14-32(20)27-15-26-21)31-7-9-35-10-8-31/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,25,34)	JUJOAHAMXIVSFA-UHFFFAOYSA-N	765488	US12391697, Example 114	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765488&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319258	520666943							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712031	Cc1cc(-c2ncnn3cc(N4CCN(C)[C@@H](C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H34N8O2/c1-17-11-19(7-8-20(17)13-28-25(36)24-31-26(37-32-24)27(3,4)5)23-22-12-21(15-35(22)30-16-29-23)34-10-9-33(6)18(2)14-34/h7-8,11-12,15-16,18H,9-10,13-14H2,1-6H3,(H,28,36)	AVECFRLWSNRVBV-UHFFFAOYSA-N	765489	US12391697, Example 116	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765489&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319586	520666944							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712032	Cc1cc(-c2ncnn3cc(N4CCN(C)[C@H](C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H34N8O2/c1-17-11-19(7-8-20(17)13-28-25(36)24-31-26(37-32-24)27(3,4)5)23-22-12-21(15-35(22)30-16-29-23)34-10-9-33(6)18(2)14-34/h7-8,11-12,15-16,18H,9-10,13-14H2,1-6H3,(H,28,36)	AVECFRLWSNRVBV-UHFFFAOYSA-N	765490	US12391697, Example 117	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765490&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319625	520666945							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712033	Cc1c(CNC(=O)c2nc(C(C)(C)C)no2)ccc(-c2ccnc3cc(N4CCOCC4)nn23)c1F	InChI=1S/C25H28FN7O3/c1-15-16(14-28-22(34)23-29-24(31-36-23)25(2,3)4)5-6-17(21(15)26)18-7-8-27-19-13-20(30-33(18)19)32-9-11-35-12-10-32/h5-8,13H,9-12,14H2,1-4H3,(H,28,34)	LGACHTDCIAVNQH-UHFFFAOYSA-N	765491	US12391697, Example 118	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765491&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319267	520666946							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712034	Cc1cc(-c2ncnn3cc(N4CCn5ccnc5C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H29N9O2/c1-17-11-18(5-6-19(17)13-29-25(37)24-32-26(38-33-24)27(2,3)4)23-21-12-20(14-36(21)31-16-30-23)35-10-9-34-8-7-28-22(34)15-35/h5-8,11-12,14,16H,9-10,13,15H2,1-4H3,(H,29,37)	SHKJDLGOWWOGOS-UHFFFAOYSA-N	765492	US12391697, Example 120	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765492&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156345778	520666947							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712035	Cc1cc(-c2ncnn3cc(N4CCn5ccnc5C4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C27H29N9O2/c1-17-11-18(5-6-19(17)13-29-24(37)25-32-26(33-38-25)27(2,3)4)23-21-12-20(14-36(21)31-16-30-23)35-10-9-34-8-7-28-22(34)15-35/h5-8,11-12,14,16H,9-10,13,15H2,1-4H3,(H,29,37)	ZHIIASNJARVGFA-UHFFFAOYSA-N	765493	US12391697, Example 121	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765493&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156345776	520666948							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712036	Cc1cc(-c2ncnn3cc(N4C[C@@H](F)[C@@H](F)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H27F2N7O2/c1-14-7-15(5-6-16(14)9-28-23(35)22-31-24(36-32-22)25(2,3)4)21-20-8-17(10-34(20)30-13-29-21)33-11-18(26)19(27)12-33/h5-8,10,13,18-19H,9,11-12H2,1-4H3,(H,28,35)	NCEMUYMKPPMDFJ-UHFFFAOYSA-N	765494	US12391697, Example 122	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765494&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319414	520666949							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712037	Cc1cc(-c2ncnn3cc(N4CCN5CC(F)(F)C[C@H]5C4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C28H32F2N8O2/c1-17-9-18(5-6-19(17)12-31-24(39)25-34-26(35-40-25)27(2,3)4)23-22-10-20(14-38(22)33-16-32-23)36-7-8-37-15-28(29,30)11-21(37)13-36/h5-6,9-10,14,16,21H,7-8,11-13,15H2,1-4H3,(H,31,39)	IXAUDQJMTOIQAO-UHFFFAOYSA-N	765495	US12391697, Example 123	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765495&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319224	520666950							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712038	Cc1cc(-c2ncnn3cc(C4=CCOCC4)cc23)ccc1CNC(=O)c1coc(C(C)(C)C)n1	InChI=1S/C27H29N5O3/c1-17-11-19(5-6-20(17)13-28-25(33)22-15-35-26(31-22)27(2,3)4)24-23-12-21(14-32(23)30-16-29-24)18-7-9-34-10-8-18/h5-7,11-12,14-16H,8-10,13H2,1-4H3,(H,28,33)	IKVCACDZWMYNSK-UHFFFAOYSA-N	765496	US12391697, Example 124	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765496&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319480	520666951							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712039	Cc1cc(-c2ncnn3cc(C4=CCOCC4)cc23)ccc1CNC(=O)c1cnc(C(C)(C)C)o1	InChI=1S/C27H29N5O3/c1-17-11-19(5-6-20(17)13-28-25(33)23-14-29-26(35-23)27(2,3)4)24-22-12-21(15-32(22)31-16-30-24)18-7-9-34-10-8-18/h5-7,11-12,14-16H,8-10,13H2,1-4H3,(H,28,33)	CZQOUFGBLQPQNZ-UHFFFAOYSA-N	765497	US12391697, Example 125	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765497&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319177	520666952							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712040	Cc1cc(-c2ncnn3cc(C4=CCOCC4)cc23)ccc1CNC(=O)c1ccn(C(C)(C)C)n1	InChI=1S/C27H30N6O2/c1-18-13-20(5-6-21(18)15-28-26(34)23-7-10-33(31-23)27(2,3)4)25-24-14-22(16-32(24)30-17-29-25)19-8-11-35-12-9-19/h5-8,10,13-14,16-17H,9,11-12,15H2,1-4H3,(H,28,34)	IOFVBSVOLWBTHQ-UHFFFAOYSA-N	765498	US12391697, Example 127	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765498&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319103	520666953							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712041	Cc1cc(-c2ncnn3cc(C4=CCOCC4)cc23)ccc1CNC(=O)c1nnn(C(C)(C)C)n1	InChI=1S/C25H28N8O2/c1-16-11-18(5-6-19(16)13-26-24(34)23-29-31-33(30-23)25(2,3)4)22-21-12-20(14-32(21)28-15-27-22)17-7-9-35-10-8-17/h5-7,11-12,14-15H,8-10,13H2,1-4H3,(H,26,34)	LYUQSVZFOICQSD-UHFFFAOYSA-N	765499	US12391697, Example 128	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765499&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319210	520666954							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712042	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4C)cc23)ccc1CNC(=O)c1nnn(C(C)(C)C)n1	InChI=1S/C25H28N10O/c1-15-9-17(7-8-18(15)11-26-24(36)23-30-32-35(31-23)25(3,4)5)22-21-10-19(13-34(21)29-14-27-22)20-12-28-33(6)16(20)2/h7-10,12-14H,11H2,1-6H3,(H,26,36)	FFJFJOAFTLELAJ-UHFFFAOYSA-N	765500	US12391697, Example 129	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765500&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319349	520666955							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712043	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4C)cc23)ccc1CNC(=O)c1coc(C(C)(C)C)n1	InChI=1S/C27H29N7O2/c1-16-9-18(7-8-19(16)11-28-25(35)22-14-36-26(32-22)27(3,4)5)24-23-10-20(13-34(23)31-15-29-24)21-12-30-33(6)17(21)2/h7-10,12-15H,11H2,1-6H3,(H,28,35)	JQVRSOWVHWVSLT-UHFFFAOYSA-N	765501	US12391697, Example 130	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765501&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319287	520666956							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712044	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4C)cc23)ccc1CNC(=O)c1cnc(C(C)(C)C)o1	InChI=1S/C27H29N7O2/c1-16-9-18(7-8-19(16)11-28-25(35)23-13-29-26(36-23)27(3,4)5)24-22-10-20(14-34(22)32-15-30-24)21-12-31-33(6)17(21)2/h7-10,12-15H,11H2,1-6H3,(H,28,35)	DRCXCVKRTYBFQM-UHFFFAOYSA-N	765502	US12391697, Example 131	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765502&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156345790	520666957							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712045	CC(C)(C)c1nc(C(=O)NCc2cc(F)c(-c3ncnn4cccc34)cc2Cl)no1	InChI=1S/C20H18ClFN6O2/c1-20(2,3)19-26-17(27-30-19)18(29)23-9-11-7-14(22)12(8-13(11)21)16-15-5-4-6-28(15)25-10-24-16/h4-8,10H,9H2,1-3H3,(H,23,29)	CCXPSSTWMUKBLG-UHFFFAOYSA-N	765503	US12391697, Example 132	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765503&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319523	520666958							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712046	CC(C)(C)c1noc(C(=O)NCc2cc(F)c(-c3ncnn4cccc34)cc2Cl)n1	InChI=1S/C20H18ClFN6O2/c1-20(2,3)19-26-18(30-27-19)17(29)23-9-11-7-14(22)12(8-13(11)21)16-15-5-4-6-28(15)25-10-24-16/h4-8,10H,9H2,1-3H3,(H,23,29)	TYTWZYJSRJNNSK-UHFFFAOYSA-N	765504	US12391697, Example 133	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765504&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319426	520666959							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712047	CC(C)(C)c1nc(C(=O)NCc2cc(F)c(-c3ncnn4cccc34)cc2Cl)co1	InChI=1S/C21H19ClFN5O2/c1-21(2,3)20-27-16(10-30-20)19(29)24-9-12-7-15(23)13(8-14(12)22)18-17-5-4-6-28(17)26-11-25-18/h4-8,10-11H,9H2,1-3H3,(H,24,29)	MXPAILFNPHNPKH-UHFFFAOYSA-N	765505	US12391697, Example 134	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765505&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319619	520666960							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712048	CC(C)(C)c1cc(C(=O)NCc2cc(F)c(-c3ncnn4cccc34)cc2Cl)no1	InChI=1S/C21H19ClFN5O2/c1-21(2,3)18-9-16(27-30-18)20(29)24-10-12-7-15(23)13(8-14(12)22)19-17-5-4-6-28(17)26-11-25-19/h4-9,11H,10H2,1-3H3,(H,24,29)	JOXPMWCUCOVICH-UHFFFAOYSA-N	765506	US12391697, Example 135	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765506&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319132	520666961							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712049	CC(C)(C)n1nnc(C(=O)NCc2cc(F)c(-c3ncnn4cccc34)cc2Cl)n1	InChI=1S/C19H18ClFN8O/c1-19(2,3)29-26-17(25-27-29)18(30)22-9-11-7-14(21)12(8-13(11)20)16-15-5-4-6-28(15)24-10-23-16/h4-8,10H,9H2,1-3H3,(H,22,30)	MNMKOYAWMWURKR-UHFFFAOYSA-N	765507	US12391697, Example 136	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765507&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319218	520666962							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712050	Cc1cc(-c2ncnn3cc(N4CCO[C@H](C)C4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C26H31N7O3/c1-16-10-18(6-7-19(16)12-27-23(34)24-30-25(31-36-24)26(3,4)5)22-21-11-20(14-33(21)29-15-28-22)32-8-9-35-17(2)13-32/h6-7,10-11,14-15,17H,8-9,12-13H2,1-5H3,(H,27,34)	DBCPBSSDUDKZTI-UHFFFAOYSA-N	765508	US12391697, Example 137	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765508&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319580	520666963							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712051	Cc1cc(-c2ncnn3cc(N4CCO[C@@H](C)C4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C26H31N7O3/c1-16-10-18(6-7-19(16)12-27-23(34)24-30-25(31-36-24)26(3,4)5)22-21-11-20(14-33(21)29-15-28-22)32-8-9-35-17(2)13-32/h6-7,10-11,14-15,17H,8-9,12-13H2,1-5H3,(H,27,34)	DBCPBSSDUDKZTI-UHFFFAOYSA-N	765509	US12391697, Example 138	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765509&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319209	520666964							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
712052	Cc1cc(-c2ncnn3cc(N4CCO[C@H](C)C4)cc23)ccc1CNC(=O)c1nnn(C(C)(C)C)n1	InChI=1S/C25H31N9O2/c1-16-10-18(6-7-19(16)12-26-24(35)23-29-31-34(30-23)25(3,4)5)22-21-11-20(14-33(21)28-15-27-22)32-8-9-36-17(2)13-32/h6-7,10-11,14-15,17H,8-9,12-13H2,1-5H3,(H,26,35)	GBFOZNLIYJTRTN-UHFFFAOYSA-N	765510	US12391697, Example 139	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765510&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318971	520666965							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717793	Cc1cc(-c2ncnn3cc(N4CCO[C@@H](C)C4)cc23)ccc1CNC(=O)c1nnn(C(C)(C)C)n1	InChI=1S/C25H31N9O2/c1-16-10-18(6-7-19(16)12-26-24(35)23-29-31-34(30-23)25(3,4)5)22-21-11-20(14-33(21)28-15-27-22)32-8-9-36-17(2)13-32/h6-7,10-11,14-15,17H,8-9,12-13H2,1-5H3,(H,26,35)	GBFOZNLIYJTRTN-UHFFFAOYSA-N	765511	US12391697, Example 140	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765511&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319360	520666966							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717795	Cc1cc(-c2ncnn3cc(N4CC[C@H](F)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H28FN7O2/c1-15-9-16(5-6-17(15)11-27-23(34)22-30-24(35-31-22)25(2,3)4)21-20-10-19(13-33(20)29-14-28-21)32-8-7-18(26)12-32/h5-6,9-10,13-14,18H,7-8,11-12H2,1-4H3,(H,27,34)	GFXAYEDYGDCXDR-UHFFFAOYSA-N	765512	US12391697, Example 141	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765512&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319332	520666967							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717797	Cc1cc(-c2ncnn3cc(N4CC[C@@H](F)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H28FN7O2/c1-15-9-16(5-6-17(15)11-27-23(34)22-30-24(35-31-22)25(2,3)4)21-20-10-19(13-33(20)29-14-28-21)32-8-7-18(26)12-32/h5-6,9-10,13-14,18H,7-8,11-12H2,1-4H3,(H,27,34)	GFXAYEDYGDCXDR-UHFFFAOYSA-N	765513	US12391697, Example 142	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765513&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319485	520666968							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717799	Cc1cc(-c2ncnn3cc(N4CCO[C@H](C)C4)cc23)ccc1CNC(=O)c1coc(C(C)(C)C)n1	InChI=1S/C27H32N6O3/c1-17-10-19(6-7-20(17)12-28-25(34)22-15-36-26(31-22)27(3,4)5)24-23-11-21(14-33(23)30-16-29-24)32-8-9-35-18(2)13-32/h6-7,10-11,14-16,18H,8-9,12-13H2,1-5H3,(H,28,34)	DRRXNSOGESLYKT-UHFFFAOYSA-N	765514	US12391697, Example 143	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765514&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319624	520666969							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717801	Cc1cc(-c2ncnn3cc(N4CCO[C@@H](C)C4)cc23)ccc1CNC(=O)c1coc(C(C)(C)C)n1	InChI=1S/C27H32N6O3/c1-17-10-19(6-7-20(17)12-28-25(34)22-15-36-26(31-22)27(3,4)5)24-23-11-21(14-33(23)30-16-29-24)32-8-9-35-18(2)13-32/h6-7,10-11,14-16,18H,8-9,12-13H2,1-5H3,(H,28,34)	DRRXNSOGESLYKT-UHFFFAOYSA-N	765515	US12391697, Example 144	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765515&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319564	520666970							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717804	Cc1cc(-c2ncnn3cc(-c4cnn(CC(F)F)c4)cc23)ccc1CNC(=O)c1cnn(C(C)(C)C)c1	InChI=1S/C27H28F2N8O/c1-17-7-18(5-6-19(17)9-30-26(38)22-11-33-37(14-22)27(2,3)4)25-23-8-20(13-36(23)34-16-31-25)21-10-32-35(12-21)15-24(28)29/h5-8,10-14,16,24H,9,15H2,1-4H3,(H,30,38)	UYKBPFWBIGNNTM-UHFFFAOYSA-N	765516	US12391697, Example 145	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765516&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319106	520666971							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717806	Cc1cc(-c2ncnn3cc(-c4cnn(CC(F)F)c4)cc23)ccc1CNC(=O)c1nnn(C(C)(C)C)n1	InChI=1S/C25H26F2N10O/c1-15-7-16(5-6-17(15)9-28-24(38)23-32-34-37(33-23)25(2,3)4)22-20-8-18(12-36(20)31-14-29-22)19-10-30-35(11-19)13-21(26)27/h5-8,10-12,14,21H,9,13H2,1-4H3,(H,28,38)	FENPMBFSMPRKHP-UHFFFAOYSA-N	765517	US12391697, Example 146	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765517&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319499	520666972							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717808	CC=CC(=O)n1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C)c4)ncnn3c2)cn1	InChI=1S/C28H28N8O3/c1-6-7-23(37)36-15-21(13-31-36)20-11-22-24(30-16-32-35(22)14-20)18-8-9-19(17(2)10-18)12-29-26(38)25-33-27(39-34-25)28(3,4)5/h6-11,13-16H,12H2,1-5H3,(H,29,38)	OYKWSVZOPBMUKQ-UHFFFAOYSA-N	765518	US12391697, Example 147	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765518&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319374	520666973							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717810	Cc1cc(-c2ncnn3cc(N4CC5CC(C4)N5C)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H32N8O2/c1-16-8-17(6-7-18(16)11-28-25(36)24-31-26(37-32-24)27(2,3)4)23-22-10-21(14-35(22)30-15-29-23)34-12-19-9-20(13-34)33(19)5/h6-8,10,14-15,19-20H,9,11-13H2,1-5H3,(H,28,36)	UJLDKRAYJWCVLM-UHFFFAOYSA-N	765519	US12391697, Example 148	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765519&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319250	520666974							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717812	Cc1cc(-c2ncnn3cc(C4CCN(C)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H31N7O2/c1-16-10-17(6-7-18(16)12-27-24(34)23-30-25(35-31-23)26(2,3)4)22-21-11-20(14-33(21)29-15-28-22)19-8-9-32(5)13-19/h6-7,10-11,14-15,19H,8-9,12-13H2,1-5H3,(H,27,34)	MXYHAPCYNGFJMO-UHFFFAOYSA-N	765520	US12391697, Example 149	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765520&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319245	520666975							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717815	Cc1cc(-c2ncnn3cc(-c4cnn(C5CC5)c4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H28N8O2/c1-16-9-17(5-6-18(16)11-28-25(36)24-32-26(37-33-24)27(2,3)4)23-22-10-19(13-35(22)31-15-29-23)20-12-30-34(14-20)21-7-8-21/h5-6,9-10,12-15,21H,7-8,11H2,1-4H3,(H,28,36)	HBJIXGBKGXEBII-UHFFFAOYSA-N	765521	US12391697, Example 150	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765521&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319310	520666976							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717818	Cc1cc(-c2ncnn3cccc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C21H22N6O2/c1-13-10-14(17-16-6-5-9-27(16)24-12-23-17)7-8-15(13)11-22-19(28)18-25-20(29-26-18)21(2,3)4/h5-10,12H,11H2,1-4H3,(H,22,28)	QZCUPDCPCPIVIS-UHFFFAOYSA-N	765522	US12391697, Example 151	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765522&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319288	520666977							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717820	Cc1cc(-c2ncnn3cccc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C21H22N6O2/c1-13-10-14(17-16-6-5-9-27(16)24-12-23-17)7-8-15(13)11-22-18(28)19-25-20(26-29-19)21(2,3)4/h5-10,12H,11H2,1-4H3,(H,22,28)	WGJNPVBHRNBRFO-UHFFFAOYSA-N	765523	US12391697, Example 152	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765523&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318965	520666978							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717822	CC(C)(C)c1noc(C(=O)NCc2ccc(-c3ncnn4cccc34)c(F)c2C2CC2)n1	InChI=1S/C23H23FN6O2/c1-23(2,3)22-28-21(32-29-22)20(31)25-11-14-8-9-15(18(24)17(14)13-6-7-13)19-16-5-4-10-30(16)27-12-26-19/h4-5,8-10,12-13H,6-7,11H2,1-3H3,(H,25,31)	XDECRAFASGNVGM-UHFFFAOYSA-N	765524	US12391697, Example 153	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765524&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319617	520666979							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717825	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2Cl)no1	InChI=1S/C24H25ClFN7O3/c1-24(2,3)23-30-21(31-36-23)22(34)27-11-14-4-5-16(19(26)18(14)25)20-17-10-15(12-33(17)29-13-28-20)32-6-8-35-9-7-32/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,27,34)	MVKSMWYTNDAIOB-UHFFFAOYSA-N	765525	US12391697, Example 154	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765525&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319159	520666980							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717827	CC(C)(C)n1cc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2Cl)cn1	InChI=1S/C25H27ClFN7O2/c1-25(2,3)34-13-17(12-30-34)24(35)28-11-16-4-5-19(22(27)21(16)26)23-20-10-18(14-33(20)31-15-29-23)32-6-8-36-9-7-32/h4-5,10,12-15H,6-9,11H2,1-3H3,(H,28,35)	UNMOTDRZAPEJQG-UHFFFAOYSA-N	765526	US12391697, Example 155	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765526&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319575	520666981							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717830	CC(C)(C)c1nnc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2Cl)o1	InChI=1S/C24H25ClFN7O3/c1-24(2,3)23-31-30-22(36-23)21(34)27-11-14-4-5-16(19(26)18(14)25)20-17-10-15(12-33(17)29-13-28-20)32-6-8-35-9-7-32/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,27,34)	LLRQLXZQKJUGGA-UHFFFAOYSA-N	765527	US12391697, Example 156	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765527&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319168	520666982							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717833	CC(C)(C)n1cc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2Cl)nn1	InChI=1S/C24H26ClFN8O2/c1-24(2,3)34-13-18(30-31-34)23(35)27-11-15-4-5-17(21(26)20(15)25)22-19-10-16(12-33(19)29-14-28-22)32-6-8-36-9-7-32/h4-5,10,12-14H,6-9,11H2,1-3H3,(H,27,35)	OWIPCTZSSATJOK-UHFFFAOYSA-N	765528	US12391697, Example 157	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765528&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319166	520666983							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717838	CC(C)(C)n1ccc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2Cl)n1	InChI=1S/C25H27ClFN7O2/c1-25(2,3)34-7-6-19(31-34)24(35)28-13-16-4-5-18(22(27)21(16)26)23-20-12-17(14-33(20)30-15-29-23)32-8-10-36-11-9-32/h4-7,12,14-15H,8-11,13H2,1-3H3,(H,28,35)	DEEIGMNTPSXTMD-UHFFFAOYSA-N	765529	US12391697, Example 158	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765529&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318963	520666984							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717840	CC(C)(C)c1noc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2Cl)n1	InChI=1S/C24H26ClN7O3/c1-24(2,3)23-29-22(35-30-23)21(33)26-12-16-5-4-15(10-18(16)25)20-19-11-17(13-32(19)28-14-27-20)31-6-8-34-9-7-31/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H,26,33)	LYFXTSMWKWYORA-UHFFFAOYSA-N	765530	US12391697, Example 159	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765530&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319372	520666985							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717842	CC(C)(C)n1cc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2Cl)cn1	InChI=1S/C25H28ClN7O2/c1-25(2,3)33-14-19(13-29-33)24(34)27-12-18-5-4-17(10-21(18)26)23-22-11-20(15-32(22)30-16-28-23)31-6-8-35-9-7-31/h4-5,10-11,13-16H,6-9,12H2,1-3H3,(H,27,34)	MWXHMMDZDSNTAZ-UHFFFAOYSA-N	765531	US12391697, Example 160	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765531&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319620	520666986							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717844	CC(C)(C)c1nnc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2Cl)o1	InChI=1S/C24H26ClN7O3/c1-24(2,3)23-30-29-22(35-23)21(33)26-12-16-5-4-15(10-18(16)25)20-19-11-17(13-32(19)28-14-27-20)31-6-8-34-9-7-31/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H,26,33)	RWZCZIVUWDFOJE-UHFFFAOYSA-N	765532	US12391697, Example 161	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765532&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319524	520666987							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717846	CC(C)(C)n1cc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2Cl)nn1	InChI=1S/C24H27ClN8O2/c1-24(2,3)33-14-20(29-30-33)23(34)26-12-17-5-4-16(10-19(17)25)22-21-11-18(13-32(21)28-15-27-22)31-6-8-35-9-7-31/h4-5,10-11,13-15H,6-9,12H2,1-3H3,(H,26,34)	GQTDMSCFYPBBJI-UHFFFAOYSA-N	765533	US12391697, Example 162	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765533&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319213	520666988							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717848	CC(C)(C)c1nnc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2C2CC2)o1	InChI=1S/C27H30FN7O3/c1-27(2,3)26-33-32-25(38-26)24(36)29-13-17-6-7-19(22(28)21(17)16-4-5-16)23-20-12-18(14-35(20)31-15-30-23)34-8-10-37-11-9-34/h6-7,12,14-16H,4-5,8-11,13H2,1-3H3,(H,29,36)	VHXOVBHELMRXIY-UHFFFAOYSA-N	765534	US12391697, Example 163	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765534&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319365	520666989							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717852	CC(C)(C)n1cc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2C2CC2)nn1	InChI=1S/C27H31FN8O2/c1-27(2,3)36-15-21(32-33-36)26(37)29-13-18-6-7-20(24(28)23(18)17-4-5-17)25-22-12-19(14-35(22)31-16-30-25)34-8-10-38-11-9-34/h6-7,12,14-17H,4-5,8-11,13H2,1-3H3,(H,29,37)	MOIOCHGWWLEMMV-UHFFFAOYSA-N	765535	US12391697, Example 164	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765535&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319610	520666990							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717856	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1nnc(C(C)(C)C)o1	InChI=1S/C25H26N8O2/c1-15-8-16(6-7-17(15)10-26-22(34)23-30-31-24(35-23)25(2,3)4)21-20-9-18(13-33(20)29-14-27-21)19-11-28-32(5)12-19/h6-9,11-14H,10H2,1-5H3,(H,26,34)	MVYOYTPVPIVXGW-UHFFFAOYSA-N	765536	US12391697, Example 165	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765536&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318983	520666991							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717858	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1cn(C(C)(C)C)nn1	InChI=1S/C25H27N9O/c1-16-8-17(6-7-18(16)10-26-24(35)21-14-34(31-30-21)25(2,3)4)23-22-9-19(13-33(22)29-15-27-23)20-11-28-32(5)12-20/h6-9,11-15H,10H2,1-5H3,(H,26,35)	BUMXJZWEIOMRMV-UHFFFAOYSA-N	765537	US12391697, Example 166	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765537&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319495	520666992							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717860	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1cnn(C(C)(C)C)c1	InChI=1S/C26H28N8O/c1-17-8-18(6-7-19(17)10-27-25(35)22-12-30-34(15-22)26(2,3)4)24-23-9-20(14-33(23)31-16-28-24)21-11-29-32(5)13-21/h6-9,11-16H,10H2,1-5H3,(H,27,35)	OGTHDVNDMNVNRL-UHFFFAOYSA-N	765538	US12391697, Example 167	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765538&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319348	520666993							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717862	Cc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1ccn(C(C)(C)C)n1	InChI=1S/C26H28N8O/c1-17-10-18(6-7-19(17)12-27-25(35)22-8-9-34(31-22)26(2,3)4)24-23-11-20(15-33(23)30-16-28-24)21-13-29-32(5)14-21/h6-11,13-16H,12H2,1-5H3,(H,27,35)	BSZJMDGMZYSXMD-UHFFFAOYSA-N	765539	US12391697, Example 168	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765539&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319248	520666994							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717864	Cc1cc(-c2ncnn3cc(-c4cccnc4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H25N7O2/c1-16-10-17(7-8-18(16)13-28-24(34)23-31-25(35-32-23)26(2,3)4)22-21-11-20(14-33(21)30-15-29-22)19-6-5-9-27-12-19/h5-12,14-15H,13H2,1-4H3,(H,28,34)	UERRKQZEZXPWHR-UHFFFAOYSA-N	765540	US12391697, Example 169	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765540&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319202	520666995							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717867	Cc1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C)c4)ncnn3c2)cnn1	InChI=1S/C26H26N8O2/c1-15-8-17(6-7-18(15)11-27-24(35)23-31-25(36-33-23)26(3,4)5)22-21-10-20(13-34(21)30-14-28-22)19-9-16(2)32-29-12-19/h6-10,12-14H,11H2,1-5H3,(H,27,35)	LJYMXIUXXDRCGC-UHFFFAOYSA-N	765541	US12391697, Example 170	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765541&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319407	520666996							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717869	Cc1cc(-c2cc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(C)c4)ncnn3c2)cnn1	InChI=1S/C26H26N8O2/c1-15-8-17(6-7-18(15)11-27-23(35)24-31-25(33-36-24)26(3,4)5)22-21-10-20(13-34(21)30-14-28-22)19-9-16(2)32-29-12-19/h6-10,12-14H,11H2,1-5H3,(H,27,35)	QOWCRJDUGNMRLV-UHFFFAOYSA-N	765542	US12391697, Example 171	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765542&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319313	520666997							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717871	Cc1cc(-c2ncnn3cc(-c4cnsc4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C24H23N7O2S/c1-14-7-15(20-19-8-17(18-10-28-34-12-18)11-31(19)27-13-26-20)5-6-16(14)9-25-22(32)21-29-23(33-30-21)24(2,3)4/h5-8,10-13H,9H2,1-4H3,(H,25,32)	HYAUNPMOUFBNII-UHFFFAOYSA-N	765543	US12391697, Example 172	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765543&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319387	520666998							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717874	Cc1cc(-c2ncnn3cc(-c4cnsc4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C24H23N7O2S/c1-14-7-15(20-19-8-17(18-10-28-34-12-18)11-31(19)27-13-26-20)5-6-16(14)9-25-21(32)22-29-23(30-33-22)24(2,3)4/h5-8,10-13H,9H2,1-4H3,(H,25,32)	ZMCCCRPTMZVYKY-UHFFFAOYSA-N	765544	US12391697, Example 173	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765544&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318968	520666999							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717876	COCCN(C)c1cc2c(-c3ccc(CNC(=O)c4noc(C(C)(C)C)n4)c(C)c3)ncnn2c1	InChI=1S/C25H31N7O3/c1-16-11-17(21-20-12-19(31(5)9-10-34-6)14-32(20)28-15-27-21)7-8-18(16)13-26-23(33)22-29-24(35-30-22)25(2,3)4/h7-8,11-12,14-15H,9-10,13H2,1-6H3,(H,26,33)	BDTIHZXKTVJHHV-UHFFFAOYSA-N	765545	US12391697, Example 174	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765545&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319201	520667000							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717878	Cc1cc(-c2ncnn3cc(N4CCOCC4)cc23)ccc1CNC(=O)c1ccn(C(C)(C)C)n1	InChI=1S/C26H31N7O2/c1-18-13-19(5-6-20(18)15-27-25(34)22-7-8-33(30-22)26(2,3)4)24-23-14-21(16-32(23)29-17-28-24)31-9-11-35-12-10-31/h5-8,13-14,16-17H,9-12,15H2,1-4H3,(H,27,34)	TZWPVVIOOOPAGE-UHFFFAOYSA-N	765546	US12391697, Example 175	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765546&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319573	520667001							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717880	Cc1cc(-c2ncnn3cc(N4CCOCC4)cc23)ccc1CNC(=O)c1coc(C(C)(C)C)n1	InChI=1S/C26H30N6O3/c1-17-11-18(5-6-19(17)13-27-24(33)21-15-35-25(30-21)26(2,3)4)23-22-12-20(14-32(22)29-16-28-23)31-7-9-34-10-8-31/h5-6,11-12,14-16H,7-10,13H2,1-4H3,(H,27,33)	NKYRMPAOPWFDDY-UHFFFAOYSA-N	765547	US12391697, Example 176	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765547&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319446	520667002							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717882	Cc1cc(-c2ncnn3cc(N4CCN(C)C(=O)C4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H30N8O3/c1-16-10-17(6-7-18(16)12-27-24(36)23-30-25(37-31-23)26(2,3)4)22-20-11-19(13-34(20)29-15-28-22)33-9-8-32(5)21(35)14-33/h6-7,10-11,13,15H,8-9,12,14H2,1-5H3,(H,27,36)	DSWPVRYHAZNUQP-UHFFFAOYSA-N	765548	US12391697, Example 177	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765548&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319611	520667003							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717884	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cccc34)cc2Cl)no1	InChI=1S/C20H19ClN6O2/c1-20(2,3)19-25-17(26-29-19)18(28)22-10-13-7-6-12(9-14(13)21)16-15-5-4-8-27(15)24-11-23-16/h4-9,11H,10H2,1-3H3,(H,22,28)	UABUNKCYKGXPQT-UHFFFAOYSA-N	765549	US12391697, Example 178	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765549&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319185	520667004							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717886	Cc1cc(-c2ncnn3cccc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C21H22N6O2/c1-13-10-14(17-16-6-5-9-27(16)24-12-23-17)7-8-15(13)11-22-19(28)18-25-20(29-26-18)21(2,3)4/h5-10,12H,11H2,1-4H3,(H,22,28)	QZCUPDCPCPIVIS-UHFFFAOYSA-N	765550	US12391697, Example 179	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765550&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319288	520667005							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717888	COc1c(CNC(=O)c2noc(C(C)(C)C)n2)ccc(-c2ncnn3cccc23)c1F	InChI=1S/C21H21FN6O3/c1-21(2,3)20-26-18(27-31-20)19(29)23-10-12-7-8-13(15(22)17(12)30-4)16-14-6-5-9-28(14)25-11-24-16/h5-9,11H,10H2,1-4H3,(H,23,29)	FIBZVIXPPHBEIP-UHFFFAOYSA-N	765551	US12391697, Example 180	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765551&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318951	520667006							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717890	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cccc34)cc2C(F)F)no1	InChI=1S/C21H20F2N6O2/c1-21(2,3)20-27-18(28-31-20)19(30)24-10-13-7-6-12(9-14(13)17(22)23)16-15-5-4-8-29(15)26-11-25-16/h4-9,11,17H,10H2,1-3H3,(H,24,30)	KSWMXEMFHFNQFL-UHFFFAOYSA-N	765552	US12391697, Example 181	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765552&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319138	520667007							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717892	Cc1cc(-c2ncnn3cccc23)ccc1CNC(=O)c1ccn(C(C)(C)C)n1	InChI=1S/C22H24N6O/c1-15-12-16(20-19-6-5-10-27(19)25-14-24-20)7-8-17(15)13-23-21(29)18-9-11-28(26-18)22(2,3)4/h5-12,14H,13H2,1-4H3,(H,23,29)	RIPMLEXNRXSBNZ-UHFFFAOYSA-N	765553	US12391697, Example 182	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765553&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319449	520667008							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717894	Cc1cc(-c2ncnn3cccc23)ccc1CNC(=O)c1cnn(C(C)(C)C)c1	InChI=1S/C22H24N6O/c1-15-10-16(20-19-6-5-9-27(19)26-14-24-20)7-8-17(15)11-23-21(29)18-12-25-28(13-18)22(2,3)4/h5-10,12-14H,11H2,1-4H3,(H,23,29)	MDGKYEZKFLXLQY-UHFFFAOYSA-N	765554	US12391697, Example 183	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765554&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319661	520667009							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717896	Cc1cc(-c2ncnn3cccc23)ccc1CNC(=O)c1cn(C(C)(C)C)nn1	InChI=1S/C21H23N7O/c1-14-10-15(19-18-6-5-9-27(18)24-13-23-19)7-8-16(14)11-22-20(29)17-12-28(26-25-17)21(2,3)4/h5-10,12-13H,11H2,1-4H3,(H,22,29)	DNAJUAUOXLQVKR-UHFFFAOYSA-N	765555	US12391697, Example 184	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765555&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319658	520667010							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717898	Cc1cc(-c2ncnn3cccc23)ccc1CNC(=O)c1nnc(C(C)(C)C)o1	InChI=1S/C21H22N6O2/c1-13-10-14(17-16-6-5-9-27(16)24-12-23-17)7-8-15(13)11-22-18(28)19-25-26-20(29-19)21(2,3)4/h5-10,12H,11H2,1-4H3,(H,22,28)	NFZLCPHVJBCBBO-UHFFFAOYSA-N	765556	US12391697, Example 185	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765556&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319605	520667011							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717900	CC(C)(C)c1noc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C(F)(F)F)n1	InChI=1S/C25H26F3N7O3/c1-24(2,3)23-32-22(38-33-23)21(36)29-12-16-5-4-15(10-18(16)25(26,27)28)20-19-11-17(13-35(19)31-14-30-20)34-6-8-37-9-7-34/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H,29,36)	IBAAXPPBJIYEBR-UHFFFAOYSA-N	765557	US12391697, Example 186	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765557&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319042	520667012							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717904	CC(C)(C)n1cc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C(F)(F)F)nn1	InChI=1S/C25H27F3N8O2/c1-24(2,3)36-14-20(32-33-36)23(37)29-12-17-5-4-16(10-19(17)25(26,27)28)22-21-11-18(13-35(21)31-15-30-22)34-6-8-38-9-7-34/h4-5,10-11,13-15H,6-9,12H2,1-3H3,(H,29,37)	UGNAJBZRCCFWJM-UHFFFAOYSA-N	765558	US12391697, Example 187	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765558&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319102	520667013							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
717906	COc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1cn(C(C)(C)C)nn1	InChI=1S/C25H27N9O2/c1-25(2,3)34-14-20(30-31-34)24(35)26-10-17-7-6-16(9-22(17)36-5)23-21-8-18(13-33(21)29-15-27-23)19-11-28-32(4)12-19/h6-9,11-15H,10H2,1-5H3,(H,26,35)	YFBNXFNOQQQBTJ-UHFFFAOYSA-N	765559	US12391697, Example 188	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765559&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319595	520667014							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721866	COc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1nc(C(C)(C)C)no1	InChI=1S/C25H26N8O3/c1-25(2,3)24-30-23(36-31-24)22(34)26-10-16-7-6-15(9-20(16)35-5)21-19-8-17(13-33(19)29-14-27-21)18-11-28-32(4)12-18/h6-9,11-14H,10H2,1-5H3,(H,26,34)	IIODXDRDAJQWPS-UHFFFAOYSA-N	765560	US12391697, Example 189	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765560&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319452	520667015							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721867	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(C(F)F)c4)ncnn3c2)cn1	InChI=1S/C25H24F2N8O2/c1-25(2,3)24-32-23(37-33-24)22(36)28-9-15-6-5-14(7-18(15)21(26)27)20-19-8-16(12-35(19)31-13-29-20)17-10-30-34(4)11-17/h5-8,10-13,21H,9H2,1-4H3,(H,28,36)	CNCFCUOJSIMCBR-UHFFFAOYSA-N	765561	US12391697, Example 190	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765561&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319373	520667016							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721868	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5nnc(C(C)(C)C)o5)c(C(F)F)c4)ncnn3c2)cn1	InChI=1S/C25H24F2N8O2/c1-25(2,3)24-33-32-23(37-24)22(36)28-9-15-6-5-14(7-18(15)21(26)27)20-19-8-16(12-35(19)31-13-29-20)17-10-30-34(4)11-17/h5-8,10-13,21H,9H2,1-4H3,(H,28,36)	UXVDZZMEXHBPIX-UHFFFAOYSA-N	765562	US12391697, Example 191	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765562&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319039	520667017							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721869	CC(C)(C)c1noc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C(F)F)n1	InChI=1S/C25H27F2N7O3/c1-25(2,3)24-31-23(37-32-24)22(35)28-12-16-5-4-15(10-18(16)21(26)27)20-19-11-17(13-34(19)30-14-29-20)33-6-8-36-9-7-33/h4-5,10-11,13-14,21H,6-9,12H2,1-3H3,(H,28,35)	DATXDYJYGKSUQC-UHFFFAOYSA-N	765563	US12391697, Example 192	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765563&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319098	520667018							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721870	CC(C)(C)c1nnc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C(F)F)o1	InChI=1S/C25H27F2N7O3/c1-25(2,3)24-32-31-23(37-24)22(35)28-12-16-5-4-15(10-18(16)21(26)27)20-19-11-17(13-34(19)30-14-29-20)33-6-8-36-9-7-33/h4-5,10-11,13-14,21H,6-9,12H2,1-3H3,(H,28,35)	WVHIJVINWDGTAU-UHFFFAOYSA-N	765564	US12391697, Example 193	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765564&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319001	520667019							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721871	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(C(F)F)c4F)ncnn3c2)cn1	InChI=1S/C25H23F3N8O2/c1-25(2,3)24-33-23(38-34-24)22(37)29-8-13-5-6-16(19(26)18(13)21(27)28)20-17-7-14(11-36(17)32-12-30-20)15-9-31-35(4)10-15/h5-7,9-12,21H,8H2,1-4H3,(H,29,37)	XPZDBJBLXCWQJC-UHFFFAOYSA-N	765565	US12391697, Example 194	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765565&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319060	520667020							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721872	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5cn(C(C)(C)C)nn5)c(C(F)F)c4F)ncnn3c2)cn1	InChI=1S/C25H24F3N9O/c1-25(2,3)37-12-18(33-34-37)24(38)29-8-14-5-6-17(21(26)20(14)23(27)28)22-19-7-15(11-36(19)32-13-30-22)16-9-31-35(4)10-16/h5-7,9-13,23H,8H2,1-4H3,(H,29,38)	YIFNSQVRQBBQGR-UHFFFAOYSA-N	765566	US12391697, Example 195	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765566&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319208	520667021							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721873	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5nnc(C(C)(C)C)o5)c(C(F)F)c4F)ncnn3c2)cn1	InChI=1S/C25H23F3N8O2/c1-25(2,3)24-34-33-23(38-24)22(37)29-8-13-5-6-16(19(26)18(13)21(27)28)20-17-7-14(11-36(17)32-12-30-20)15-9-31-35(4)10-15/h5-7,9-12,21H,8H2,1-4H3,(H,29,37)	YBWLFHWKMSXBOO-UHFFFAOYSA-N	765567	US12391697, Example 196	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765567&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			167327328	520667022							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721874	COc1cc(-c2ncnn3cc(-c4cnn(C)c4)cc23)ccc1CNC(=O)c1nnc(C(C)(C)C)o1	InChI=1S/C25H26N8O3/c1-25(2,3)24-31-30-23(36-24)22(34)26-10-16-7-6-15(9-20(16)35-5)21-19-8-17(13-33(19)29-14-27-21)18-11-28-32(4)12-18/h6-9,11-14H,10H2,1-5H3,(H,26,34)	MYGQREZGMSMRLU-UHFFFAOYSA-N	765568	US12391697, Example 197	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765568&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319285	520667023							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721875	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C(F)F)co1	InChI=1S/C26H28F2N6O3/c1-26(2,3)25-32-20(14-37-25)24(35)29-12-17-5-4-16(10-19(17)23(27)28)22-21-11-18(13-34(21)31-15-30-22)33-6-8-36-9-7-33/h4-5,10-11,13-15,23H,6-9,12H2,1-3H3,(H,29,35)	ODPALRULWXLQGM-UHFFFAOYSA-N	765569	US12391697, Example 198	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765569&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319362	520667024							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721876	CC(C)(C)c1nnc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2C(F)F)o1	InChI=1S/C25H26F3N7O3/c1-25(2,3)24-33-32-23(38-24)22(36)29-11-14-4-5-16(19(26)18(14)21(27)28)20-17-10-15(12-35(17)31-13-30-20)34-6-8-37-9-7-34/h4-5,10,12-13,21H,6-9,11H2,1-3H3,(H,29,36)	CCIDIULTJBFRCZ-UHFFFAOYSA-N	765570	US12391697, Example 199	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765570&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319467	520667025							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721877	COc1c(CNC(=O)c2cn(C(C)(C)C)nn2)ccc(-c2ncnn3cc(-c4cnn(C)c4)cc23)c1F	InChI=1S/C25H26FN9O2/c1-25(2,3)35-13-19(31-32-35)24(36)27-9-15-6-7-18(21(26)23(15)37-5)22-20-8-16(12-34(20)30-14-28-22)17-10-29-33(4)11-17/h6-8,10-14H,9H2,1-5H3,(H,27,36)	MKBNWTDANXGULB-UHFFFAOYSA-N	765571	US12391697, Example 200	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765571&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319370	520667026							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721878	COc1c(CNC(=O)c2nnc(C(C)(C)C)o2)ccc(-c2ncnn3cc(-c4cnn(C)c4)cc23)c1F	InChI=1S/C25H25FN8O3/c1-25(2,3)24-32-31-23(37-24)22(35)27-9-14-6-7-17(19(26)21(14)36-5)20-18-8-15(12-34(18)30-13-28-20)16-10-29-33(4)11-16/h6-8,10-13H,9H2,1-5H3,(H,27,35)	OJXARQYISRMFSH-UHFFFAOYSA-N	765572	US12391697, Example 201	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765572&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318976	520667027							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721879	COc1c(CNC(=O)c2ccn(C(C)(C)C)n2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C26H30FN7O3/c1-26(2,3)34-8-7-20(31-34)25(35)28-14-17-5-6-19(22(27)24(17)36-4)23-21-13-18(15-33(21)30-16-29-23)32-9-11-37-12-10-32/h5-8,13,15-16H,9-12,14H2,1-4H3,(H,28,35)	RHQBKHAFXUIDLB-UHFFFAOYSA-N	765573	US12391697, Example 202	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765573&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319199	520667028							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721880	COc1c(CNC(=O)c2nc(C(C)(C)C)no2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C25H28FN7O4/c1-25(2,3)24-30-23(37-31-24)22(34)27-12-15-5-6-17(19(26)21(15)35-4)20-18-11-16(13-33(18)29-14-28-20)32-7-9-36-10-8-32/h5-6,11,13-14H,7-10,12H2,1-4H3,(H,27,34)	VPUNXXRIVGIECL-UHFFFAOYSA-N	765574	US12391697, Example 203	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765574&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319117	520667029							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721881	C[C@@H](NC(=O)c1nnc(C(C)(C)C)o1)c1ccc(-c2ncnn3cc(N4CCOCC4)cc23)cc1Cl	InChI=1S/C25H28ClN7O3/c1-15(29-22(34)23-30-31-24(36-23)25(2,3)4)18-6-5-16(11-19(18)26)21-20-12-17(13-33(20)28-14-27-21)32-7-9-35-10-8-32/h5-6,11-15H,7-10H2,1-4H3,(H,29,34)	BLTDKURFJUUPOC-UHFFFAOYSA-N	765575	US12391697, Example 204	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765575&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318981	520667030							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721882	CC(C)(C)n1cc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C2CC2)nn1	InChI=1S/C27H32N8O2/c1-27(2,3)35-16-23(31-32-35)26(36)28-14-20-7-6-19(12-22(20)18-4-5-18)25-24-13-21(15-34(24)30-17-29-25)33-8-10-37-11-9-33/h6-7,12-13,15-18H,4-5,8-11,14H2,1-3H3,(H,28,36)	YYAHROJQDXQBIB-UHFFFAOYSA-N	765576	US12391697, Example 205	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765576&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319290	520667031							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721883	CC(C)(C)c1noc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C2CC2)n1	InChI=1S/C27H31N7O3/c1-27(2,3)26-31-25(37-32-26)24(35)28-14-19-7-6-18(12-21(19)17-4-5-17)23-22-13-20(15-34(22)30-16-29-23)33-8-10-36-11-9-33/h6-7,12-13,15-17H,4-5,8-11,14H2,1-3H3,(H,28,35)	SRCZUXPSKKNAMF-UHFFFAOYSA-N	765577	US12391697, Example 206	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765577&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319338	520667032							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721884	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(CC(F)F)c4)ncnn3c2)cn1	InChI=1S/C26H26F2N8O2/c1-26(2,3)25-33-24(38-34-25)23(37)29-10-16-6-5-15(7-17(16)9-21(27)28)22-20-8-18(13-36(20)32-14-30-22)19-11-31-35(4)12-19/h5-8,11-14,21H,9-10H2,1-4H3,(H,29,37)	CVHAAVLHORPDKW-UHFFFAOYSA-N	765578	US12391697, Example 207	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765578&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318988	520667033							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721885	CC(C)(C)n1cc(C(=O)NCc2ccc(-c3ncnn4cc(C5=CCOCC5)cc34)cc2C(F)F)cn1	InChI=1S/C27H28F2N6O2/c1-27(2,3)35-15-21(13-32-35)26(36)30-12-19-5-4-18(10-22(19)25(28)29)24-23-11-20(14-34(23)33-16-31-24)17-6-8-37-9-7-17/h4-6,10-11,13-16,25H,7-9,12H2,1-3H3,(H,30,36)	YJRUAXSVMWAPRJ-UHFFFAOYSA-N	765579	US12391697, Example 208	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765579&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319557	520667034							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721886	CC(C)(C)n1cc(C(=O)NCc2ccc(-c3ncnn4cc(-c5cnn(CC(F)F)c5)cc34)cc2C(F)F)cn1	InChI=1S/C27H26F4N8O/c1-27(2,3)39-13-20(10-35-39)26(40)32-8-17-5-4-16(6-21(17)25(30)31)24-22-7-18(12-38(22)36-15-33-24)19-9-34-37(11-19)14-23(28)29/h4-7,9-13,15,23,25H,8,14H2,1-3H3,(H,32,40)	DVQNKXBZFRBQJK-UHFFFAOYSA-N	765580	US12391697, Example 209	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765580&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319192	520667035							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721887	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(-c5cnn(CC(F)F)c5)cc34)cc2C(F)F)co1	InChI=1S/C27H25F4N7O2/c1-27(2,3)26-36-20(13-40-26)25(39)32-8-16-5-4-15(6-19(16)24(30)31)23-21-7-17(11-38(21)35-14-33-23)18-9-34-37(10-18)12-22(28)29/h4-7,9-11,13-14,22,24H,8,12H2,1-3H3,(H,32,39)	AVPHBKRBYNIWEM-UHFFFAOYSA-N	765581	US12391697, Example 210	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765581&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319507	520667036							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721888	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5coc(C(C)(C)C)n5)c(C(F)F)c4)ncnn3c2)cn1	InChI=1S/C26H25F2N7O2/c1-26(2,3)25-33-20(13-37-25)24(36)29-9-16-6-5-15(7-19(16)23(27)28)22-21-8-17(12-35(21)32-14-30-22)18-10-31-34(4)11-18/h5-8,10-14,23H,9H2,1-4H3,(H,29,36)	QSTIHOVMXVZALY-UHFFFAOYSA-N	765582	US12391697, Example 211	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765582&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319194	520667037							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721889	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5cnn(C(C)(C)C)c5)c(C(F)F)c4)ncnn3c2)cn1	InChI=1S/C26H26F2N8O/c1-26(2,3)36-14-20(11-32-36)25(37)29-9-17-6-5-16(7-21(17)24(27)28)23-22-8-18(13-35(22)33-15-30-23)19-10-31-34(4)12-19/h5-8,10-15,24H,9H2,1-4H3,(H,29,37)	GHKALWANVXHUNZ-UHFFFAOYSA-N	765583	US12391697, Example 212	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765583&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319471	520667038							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721890	CC(C)(C)c1nnc(C(=O)NCc2ccc(-c3ncnn4cc(C5=CCOCC5)cc34)cc2C(F)F)o1	InChI=1S/C26H26F2N6O3/c1-26(2,3)25-33-32-24(37-25)23(35)29-12-17-5-4-16(10-19(17)22(27)28)21-20-11-18(13-34(20)31-14-30-21)15-6-8-36-9-7-15/h4-6,10-11,13-14,22H,7-9,12H2,1-3H3,(H,29,35)	NJPZRSVXMDFOOE-UHFFFAOYSA-N	765584	US12391697, Example 213	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765584&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319419	520667039							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721891	Cc1cc(-c2ncnn3cccc23)ccc1CNC(=O)c1nnn(C(C)(C)C)n1	InChI=1S/C20H22N8O/c1-13-10-14(17-16-6-5-9-27(16)23-12-22-17)7-8-15(13)11-21-19(29)18-24-26-28(25-18)20(2,3)4/h5-10,12H,11H2,1-4H3,(H,21,29)	GIHZNGFHQSESMS-UHFFFAOYSA-N	765585	US12391697, Example 214	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765585&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319051	520667040							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721892	Cc1cc(-c2ncnn3cc(C(=O)N4CCOCC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H29N7O4/c1-16-11-17(5-6-18(16)13-27-23(34)22-30-25(37-31-22)26(2,3)4)21-20-12-19(14-33(20)29-15-28-21)24(35)32-7-9-36-10-8-32/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,27,34)	JDSYGAUYGXDYTO-UHFFFAOYSA-N	765586	US12391697, Example 215	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765586&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319114	520667041							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721893	Cc1cc(-c2ncnn3cc(C(=O)N4CCN(C)CC4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H32N8O3/c1-17-12-18(6-7-19(17)14-28-24(36)23-31-26(38-32-23)27(2,3)4)22-21-13-20(15-35(21)30-16-29-22)25(37)34-10-8-33(5)9-11-34/h6-7,12-13,15-16H,8-11,14H2,1-5H3,(H,28,36)	RQLUCNVJQPDSDH-UHFFFAOYSA-N	765587	US12391697, Example 216	Tyrosine-protein kinase BTK	Human		>10.00							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765587&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319112	520667042							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721894	COC1CN(C(=O)c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C)c4)ncnn3c2)C1	InChI=1S/C26H29N7O4/c1-15-8-16(6-7-17(15)10-27-23(34)22-30-25(37-31-22)26(2,3)4)21-20-9-18(11-33(20)29-14-28-21)24(35)32-12-19(13-32)36-5/h6-9,11,14,19H,10,12-13H2,1-5H3,(H,27,34)	WSVVLXVRIKEFJB-UHFFFAOYSA-N	765588	US12391697, Example 217	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765588&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319073	520667043							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721895	Cc1c(CNC(=O)c2noc(C(C)(C)C)n2)ccc(-c2ncnn3cccc23)c1F	InChI=1S/C21H21FN6O2/c1-12-13(10-23-19(29)18-26-20(30-27-18)21(2,3)4)7-8-14(16(12)22)17-15-6-5-9-28(15)25-11-24-17/h5-9,11H,10H2,1-4H3,(H,23,29)	KLWINFKJMGCQNS-UHFFFAOYSA-N	765589	US12391697, Example 218	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765589&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319240	520667044							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721896	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C(F)F)c4)ncnn3c2)cn1	InChI=1S/C25H24F2N8O2/c1-25(2,3)24-32-22(33-37-24)23(36)28-9-15-6-5-14(7-18(15)21(26)27)20-19-8-16(12-35(19)31-13-29-20)17-10-30-34(4)11-17/h5-8,10-13,21H,9H2,1-4H3,(H,28,36)	SKRWPNHNHMTXEM-UHFFFAOYSA-N	765590	US12391697, Example 219	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765590&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319294	520667045							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721897	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C(F)F)no1	InChI=1S/C25H27F2N7O3/c1-25(2,3)24-31-22(32-37-24)23(35)28-12-16-5-4-15(10-18(16)21(26)27)20-19-11-17(13-34(19)30-14-29-20)33-6-8-36-9-7-33/h4-5,10-11,13-14,21H,6-9,12H2,1-3H3,(H,28,35)	ODPWWZRPSOPBOL-UHFFFAOYSA-N	765591	US12391697, Example 220	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765591&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319024	520667046							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721898	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2C(F)F)no1	InChI=1S/C25H26F3N7O3/c1-25(2,3)24-32-22(33-38-24)23(36)29-11-14-4-5-16(19(26)18(14)21(27)28)20-17-10-15(12-35(17)31-13-30-20)34-6-8-37-9-7-34/h4-5,10,12-13,21H,6-9,11H2,1-3H3,(H,29,36)	ZPLIEPKEDGTWFN-UHFFFAOYSA-N	765592	US12391697, Example 221	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765592&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319603	520667047							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721899	CC(C)(C)c1coc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2C(F)F)n1	InChI=1S/C26H28F2N6O3/c1-26(2,3)21-14-37-25(32-21)24(35)29-12-17-5-4-16(10-19(17)23(27)28)22-20-11-18(13-34(20)31-15-30-22)33-6-8-36-9-7-33/h4-5,10-11,13-15,23H,6-9,12H2,1-3H3,(H,29,35)	VSAVLRIZFGDJQB-UHFFFAOYSA-N	765593	US12391697, Example 222	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765593&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318989	520667048							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721900	COc1c(CNC(=O)c2noc(C(C)(C)C)n2)ccc(-c2ncnn3cc(N4CCOCC4)cc23)c1F	InChI=1S/C25H28FN7O4/c1-25(2,3)24-30-22(31-37-24)23(34)27-12-15-5-6-17(19(26)21(15)35-4)20-18-11-16(13-33(18)29-14-28-20)32-7-9-36-10-8-32/h5-6,11,13-14H,7-10,12H2,1-4H3,(H,27,34)	SMOYCCRQJTXYIB-UHFFFAOYSA-N	765594	US12391697, Example 223	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765594&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319563	520667049							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721901	Cc1cc(-c2ncnn3cc(-c4ccc(F)cc4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H25FN6O2/c1-16-11-18(5-6-19(16)13-29-25(35)24-32-26(36-33-24)27(2,3)4)23-22-12-20(14-34(22)31-15-30-23)17-7-9-21(28)10-8-17/h5-12,14-15H,13H2,1-4H3,(H,29,35)	ABSYLEBQOOQRBO-UHFFFAOYSA-N	765595	US12391697, Example 224	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765595&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319139	520667050							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721902	Cc1cc(-c2ncnn3cc(-c4ccc(C#N)cc4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C28H25N7O2/c1-17-11-20(9-10-21(17)14-30-26(36)25-33-27(37-34-25)28(2,3)4)24-23-12-22(15-35(23)32-16-31-24)19-7-5-18(13-29)6-8-19/h5-12,15-16H,14H2,1-4H3,(H,30,36)	PAYCHPDFPDYCSO-UHFFFAOYSA-N	765596	US12391697, Example 225	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765596&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319178	520667051							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721903	Cc1cc(-c2ncnn3cc(-c4cncnc4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C25H24N8O2/c1-15-7-16(5-6-17(15)11-28-23(34)22-31-24(35-32-22)25(2,3)4)21-20-8-18(12-33(20)30-14-29-21)19-9-26-13-27-10-19/h5-10,12-14H,11H2,1-4H3,(H,28,34)	LBJYBGCXUSLQCX-UHFFFAOYSA-N	765597	US12391697, Example 226	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765597&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319088	520667052							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721904	Cc1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C)c4)ncnn3c2)ccn1	InChI=1S/C27H27N7O2/c1-16-10-19(6-7-20(16)13-29-25(35)24-32-26(36-33-24)27(3,4)5)23-22-12-21(14-34(22)31-15-30-23)18-8-9-28-17(2)11-18/h6-12,14-15H,13H2,1-5H3,(H,29,35)	YFNLPXAWGDBWKY-UHFFFAOYSA-N	765598	US12391697, Example 227	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765598&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319311	520667053							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721905	Cc1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C)c4)ncnn3c2)ccn1	InChI=1S/C27H27N7O2/c1-16-10-19(6-7-20(16)13-29-25(35)24-32-26(36-33-24)27(3,4)5)23-22-12-21(14-34(22)31-15-30-23)18-8-9-28-17(2)11-18/h6-12,14-15H,13H2,1-5H3,(H,29,35)	YFNLPXAWGDBWKY-UHFFFAOYSA-N	765599	US12391697, Example 228	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765599&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319311	520667054							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721906	Cc1cc(-c2ncnn3cc(N4CCOCC4C)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H31N7O3/c1-16-10-18(6-7-19(16)12-27-24(34)23-30-25(36-31-23)26(3,4)5)22-21-11-20(13-33(21)29-15-28-22)32-8-9-35-14-17(32)2/h6-7,10-11,13,15,17H,8-9,12,14H2,1-5H3,(H,27,34)	QHPSYIYBOOSLEJ-UHFFFAOYSA-N	765600	US12391697, Example 229	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765600&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319031	520667055							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721907	Cc1cc(-c2ncnn3cc(-c4ccccn4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C26H25N7O2/c1-16-11-17(8-9-18(16)13-28-24(34)23-31-25(35-32-23)26(2,3)4)22-21-12-19(14-33(21)30-15-29-22)20-7-5-6-10-27-20/h5-12,14-15H,13H2,1-4H3,(H,28,34)	PQRNYDJJLKXFQO-UHFFFAOYSA-N	765601	US12391697, Example 230	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765601&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319161	520667056							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721908	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(CC(F)F)c4)ncnn3c2)cn1	InChI=1S/C26H26F2N8O2/c1-26(2,3)25-33-23(34-38-25)24(37)29-10-16-6-5-15(7-17(16)9-21(27)28)22-20-8-18(13-36(20)32-14-30-22)19-11-31-35(4)12-19/h5-8,11-14,21H,9-10H2,1-4H3,(H,29,37)	XQJHGMIHBPKZQE-UHFFFAOYSA-N	765602	US12391697, Example 231	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765602&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318958	520667057							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721909	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)cc2CC(F)F)no1	InChI=1S/C26H29F2N7O3/c1-26(2,3)25-32-23(33-38-25)24(36)29-13-17-5-4-16(10-18(17)11-21(27)28)22-20-12-19(14-35(20)31-15-30-22)34-6-8-37-9-7-34/h4-5,10,12,14-15,21H,6-9,11,13H2,1-3H3,(H,29,36)	CEQAGTGPIZTPPS-UHFFFAOYSA-N	765603	US12391697, Example 232	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765603&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319232	520667058							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721910	Cn1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(CC(F)F)c4F)ncnn3c2)cn1	InChI=1S/C26H25F3N8O2/c1-26(2,3)25-34-23(35-39-25)24(38)30-9-14-5-6-17(21(29)18(14)8-20(27)28)22-19-7-15(12-37(19)33-13-31-22)16-10-32-36(4)11-16/h5-7,10-13,20H,8-9H2,1-4H3,(H,30,38)	JVEMHQKUUKMKCY-UHFFFAOYSA-N	765604	US12391697, Example 233	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765604&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319358	520667059							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721911	CC(C)(C)c1nc(C(=O)NCc2ccc(-c3ncnn4cc(N5CCOCC5)cc34)c(F)c2CC(F)F)no1	InChI=1S/C26H28F3N7O3/c1-26(2,3)25-33-23(34-39-25)24(37)30-12-15-4-5-17(21(29)18(15)11-20(27)28)22-19-10-16(13-36(19)32-14-31-22)35-6-8-38-9-7-35/h4-5,10,13-14,20H,6-9,11-12H2,1-3H3,(H,30,37)	PGFNBUFZSKMPGS-UHFFFAOYSA-N	765605	US12391697, Example 234	Tyrosine-protein kinase BTK	Human		 5.50							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765605&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319297	520667060							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721912	COc1c(CNC(=O)c2noc(C(C)(C)C)n2)ccc(-c2ncnn3cc(-c4cnn(C)c4)cc23)c1F	InChI=1S/C25H25FN8O3/c1-25(2,3)24-31-22(32-37-24)23(35)27-9-14-6-7-17(19(26)21(14)36-5)20-18-8-15(12-34(18)30-13-28-20)16-10-29-33(4)11-16/h6-8,10-13H,9H2,1-5H3,(H,27,35)	CINMVPFWLIMDPJ-UHFFFAOYSA-N	765606	US12391697, Example 235	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765606&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318967	520667061							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721913	CCn1cc(-c2cc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(C)c4)ncnn3c2)cn1	InChI=1S/C26H28N8O2/c1-6-33-13-20(12-29-33)19-10-21-22(28-15-30-34(21)14-19)17-7-8-18(16(2)9-17)11-27-24(35)23-31-25(36-32-23)26(3,4)5/h7-10,12-15H,6,11H2,1-5H3,(H,27,35)	NDEYMBLJJJGRDF-UHFFFAOYSA-N	765607	US12391697, Example 236	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765607&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156318960	520667062							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
721914	Cc1cc(-c2ncnn3cc(-c4cnn(C5CC5)c4)cc23)ccc1CNC(=O)c1noc(C(C)(C)C)n1	InChI=1S/C27H28N8O2/c1-16-9-17(5-6-18(16)11-28-25(36)24-32-26(37-33-24)27(2,3)4)23-22-10-19(13-35(22)31-15-29-23)20-12-30-34(14-20)21-7-8-21/h5-6,9-10,12-15,21H,7-8,11H2,1-4H3,(H,28,36)	HBJIXGBKGXEBII-UHFFFAOYSA-N	765608	US12391697, Example 237	Tyrosine-protein kinase BTK	Human		<1.000							US Patent		10.7270/Q2TQ66BJ			US12391697	Marx, I; Schulz, J; Hopkins, BT; Ma, B; Prince, R; Nevalainen, M	8/19/2025	11/25/2025	Biogen Ma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=765608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1846&target=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=765608&enzyme=Tyrosine-protein+kinase+BTK&column=ki&startPg=0&Increment=50&submit=Search			156319310	520667063							1	MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES	4YHF,5J87,6MNY,9EJR,9EJJ,8S9F,8FLL,8E2M,7R60,7L5P,7L5O,7KXP,7KXM,6X3P,6X3O,6X3N,6OMU,6NFH,6N9P,6DI9,6DI5,6DI3,6DI1,6DI0,5VFI,5U9D,5FBO,5FBN,8U2E,8U2D,8GC7,8EJB,4ZLZ,4ZLY,7R61,7KXQ,7N4S,7N4R,7N4Q,6O8I,7KXL,6NFI,7LTZ,7LTY,7KXO,7KXN,3P08,6S90,8YVV,6XE4,6BLN,6BKW,6BKH,6BKE,6BIK,5VGO,5KUP,4RX5,3OCS,4OTF,5ZZ4,5XYZ,6AUB,6AUA,1K2P,4NWM,6YYG,2Z0P,1B55,6HTF	Tyrosine-protein kinase BTK	BTK_HUMAN	Q06187	B2RAW1 Q32ML5