BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
887087	Cc1cccc(-c2nc3n(c2-c2cc4cnccc4s2)CC(CO)N3)n1	InChI=1S/C19H17N5OS/c1-11-3-2-4-14(21-11)17-18(24-9-13(10-25)22-19(24)23-17)16-7-12-8-20-6-5-15(12)26-16/h2-8,13,25H,9-10H2,1H3,(H,22,23)	PLLQTHRWISRIJN-UHFFFAOYSA-N	767425	[6-(6-Methylpyridin-2-yl)-5- {thieno[3,2-c]pyridin-2-yl}- 1H,2H,3H-imidazo[1,2- a][1,3]diazol-2-yl]methanol,  single enantiomer::US20250270215, Example 1	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767425&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			136232675	522825923							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
887088	Fc1ccc(Cl)cc1-c1nc2n(c1-c1ccc3ncnn3c1)CCN2	InChI=1S/C17H12ClFN6/c18-11-2-3-13(19)12(7-11)15-16(24-6-5-20-17(24)23-15)10-1-4-14-21-9-22-25(14)8-10/h1-4,7-9H,5-6H2,(H,20,23)	XPLHRCDPFBNIFF-UHFFFAOYSA-N	767426	6-(6-(5-Chloro-2-fluorophenyl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)-[1,2,4]triazolo[1,5-a]pyridine::US20250270215, Example 2	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767426&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258738	522825924							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
887089	Cc1csc(-c2nc3n(c2-c2ccc4ncnn4c2)CCN3)n1	InChI=1S/C15H13N7S/c1-9-7-23-14(19-9)12-13(21-5-4-16-15(21)20-12)10-2-3-11-17-8-18-22(11)6-10/h2-3,6-8H,4-5H2,1H3,(H,16,20)	IJIDZCPVFWGFLN-UHFFFAOYSA-N	767427	2-(5-([1,2,4]Triazolo[1,5-a]pyridin- 6-yl)-2,3-dihydro-1H-imidazo[1,2- a]imidazol-6-yl)-4-methylthiazole::US20250270215, Example 3	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767427&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258661	522825925							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
887090	Cc1cccc(-c2nc3n(c2-c2cc4cnccc4s2)CC(C(=O)O)N3)n1	InChI=1S/C19H15N5O2S/c1-10-3-2-4-12(21-10)16-17(15-7-11-8-20-6-5-14(11)27-15)24-9-13(18(25)26)22-19(24)23-16/h2-8,13H,9H2,1H3,(H,22,23)(H,25,26)	INNYJPKQGJKHML-UHFFFAOYSA-N	767428	6-(6-Methylpyridin-2-yl)-5- {thieno[3,2-c]pyridin-2-yl}- 1H,2H,3H-imidazo[1,2- a][1,3]diazole-2-carboxylic acid::US20250270215, Example 4	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767428&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			137025434	522825926							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
887091	Cc1csc(-c2nc3n(c2-c2cc4cnccc4s2)CCN3)n1	InChI=1S/C16H13N5S2/c1-9-8-22-15(19-9)13-14(21-5-4-18-16(21)20-13)12-6-10-7-17-3-2-11(10)23-12/h2-3,6-8H,4-5H2,1H3,(H,18,20)	USGKRSQWWBLPGX-UHFFFAOYSA-N	767429	2-(6-(4-Methylthiazol-2-yl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)thieno[3,2-c]pyridine::US20250270215, Example 7	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767429&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258662	522825927							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
887092	Cn1ccc(-c2nc3n(c2-c2ccc4ncnn4c2)CCN3)n1	InChI=1S/C15H14N8/c1-21-6-4-11(20-21)13-14(22-7-5-16-15(22)19-13)10-2-3-12-17-9-18-23(12)8-10/h2-4,6,8-9H,5,7H2,1H3,(H,16,19)	PYYWUCAPBRXYAL-UHFFFAOYSA-N	767430	6-(6-(1-Methyl-1H-pyrazol-3-yl)- 2,3-dihydro-1H-imidazo[1,2- a]imidazol-5-yl)-[1,2,4]triazolo[1,5- a]pyridine::US20250270215, Example 8	TGF-beta receptor type-1	Human		 7.50							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767430&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258670	522825928							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
887093	Cn1ccc(-c2nc3n(c2-c2cc4cnccc4s2)CCN3)n1	InChI=1S/C16H14N6S/c1-21-6-3-11(20-21)14-15(22-7-5-18-16(22)19-14)13-8-10-9-17-4-2-12(10)23-13/h2-4,6,8-9H,5,7H2,1H3,(H,18,19)	XEZZBUQMXKRBDS-UHFFFAOYSA-N	767431	2-(6-(1-Methyl-1H-pyrazol-3-yl)- 2,3-dihydro-1H-imidazo[1,2- a]imidazol-5-yl)thieno[3,2- c]pyridine::US20250270215, Example 9	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767431&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258746	522825929							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
887094	Clc1cccc(-c2nc3n(c2-c2ccc4ncnn4c2)CCN3)n1	InChI=1S/C16H12ClN7/c17-12-3-1-2-11(21-12)14-15(23-7-6-18-16(23)22-14)10-4-5-13-19-9-20-24(13)8-10/h1-5,8-9H,6-7H2,(H,18,22)	ZYGLRWIYZFOQOT-UHFFFAOYSA-N	767432	6-(6-(6-Chloropyridin-2-yl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)-[1,2,4]triazolo[1,5-a]pyridine::US20250270215, Example 12	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767432&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258691	522825930							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895664	Clc1cccc(-c2nc3n(c2-c2cc4cnccc4s2)CCN3)n1	InChI=1S/C17H12ClN5S/c18-14-3-1-2-11(21-14)15-16(23-7-6-20-17(23)22-15)13-8-10-9-19-5-4-12(10)24-13/h1-5,8-9H,6-7H2,(H,20,22)	IIKPDNXDMVODLN-UHFFFAOYSA-N	767433	2-(6-(6-Chloropyridin-2-yl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)thieno[3,2-c]pyridine::US20250270215, Example 13	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767433&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258671	522825931							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895665	Fc1ccc(Cl)cc1-c1nc2n(c1-c1cc3cnccc3s1)CCN2	InChI=1S/C18H12ClFN4S/c19-11-1-2-13(20)12(8-11)16-17(24-6-5-22-18(24)23-16)15-7-10-9-21-4-3-14(10)25-15/h1-4,7-9H,5-6H2,(H,22,23)	FQSIFXKSPDFXFK-UHFFFAOYSA-N	767434	2-(6-(5-Chloro-2-fluorophenyl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)thieno[3,2-c]pyridine::US20250270215, Example 14	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767434&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258780	522825932							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895666	Cc1cccc(-c2nc3n(c2-c2cccc4ncsc24)CCN3)n1	InChI=1S/C18H15N5S/c1-11-4-2-6-13(21-11)15-16(23-9-8-19-18(23)22-15)12-5-3-7-14-17(12)24-10-20-14/h2-7,10H,8-9H2,1H3,(H,19,22)	AOLNXEXJJTUCIW-UHFFFAOYSA-N	767435	1-(6-(6-Methylpyridin-2-yl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)benzo[d]thiazole::US20250270215, Example 15	TGF-beta receptor type-1	Human		 7.50							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767435&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			176872120	522825933							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895667	Cc1cccc(-c2nc3n(c2-c2ccc4nsnc4c2)CCN3)n1	InChI=1S/C17H14N6S/c1-10-3-2-4-13(19-10)15-16(23-8-7-18-17(23)20-15)11-5-6-12-14(9-11)22-24-21-12/h2-6,9H,7-8H2,1H3,(H,18,20)	FZROSOHAZIHVKG-UHFFFAOYSA-N	767436	5-(6-(6-Methylpyridin-2-yl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)benzo[c][1,2,5]thiadiazole::US20250270215, Example 17	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767436&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258754	522825934							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895668	Cc1cccc(-c2nc3n(c2-c2ccc4nonc4c2)CCN3)n1	InChI=1S/C17H14N6O/c1-10-3-2-4-13(19-10)15-16(23-8-7-18-17(23)20-15)11-5-6-12-14(9-11)22-24-21-12/h2-6,9H,7-8H2,1H3,(H,18,20)	RRYCMSDRGGUJTI-UHFFFAOYSA-N	767437	5-(6-(6-methylpyridin-2-yl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)benzo[c][1,2,5]oxadiazole::US20250270215, Example 18	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767437&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258728	522825935							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895669	CNC(=O)C1Cn2c(nc(-c3cccc(C)n3)c2-c2cc3cnccc3s2)N1	InChI=1S/C20H18N6OS/c1-11-4-3-5-13(23-11)17-18(16-8-12-9-22-7-6-15(12)28-16)26-10-14(19(27)21-2)24-20(26)25-17/h3-9,14H,10H2,1-2H3,(H,21,27)(H,24,25)	OCYMKKMWALKYEK-UHFFFAOYSA-N	767438	N-methyl-6-(6-methylpyridin-2-yl)- 5-{thieno[3,2-b]pyridin-2-yl}- 1H,2H,3H-imidazo[1,2- a][1,3]diazole-2-carboxamide::US20250270215, Example 19	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767438&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			177821786	522825936							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895670	CCOC(=O)CC1Cn2c(nc(-c3cccc(C)n3)c2-c2cc3cnccc3s2)N1	InChI=1S/C22H21N5O2S/c1-3-29-19(28)10-15-12-27-21(18-9-14-11-23-8-7-17(14)30-18)20(26-22(27)25-15)16-6-4-5-13(2)24-16/h4-9,11,15H,3,10,12H2,1-2H3,(H,25,26)	XYNADDRVTSTUPZ-UHFFFAOYSA-N	767439	Ethyl 2-[6-(6-methylpyridin-2-yl)-5- {thieno[3,2-c]pyridin-2-yl}- 1H,2H,3H-imidazo[1,2- a][1,3]diazol-2-yl]acetate::US20250270215, Example 20	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767439&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			170340919	522825937							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895671	Cc1cccc(-c2nc3n(c2-c2cc4cnccc4s2)CC(CC(=O)O)N3)n1	InChI=1S/C20H17N5O2S/c1-11-3-2-4-14(22-11)18-19(16-7-12-9-21-6-5-15(12)28-16)25-10-13(8-17(26)27)23-20(25)24-18/h2-7,9,13H,8,10H2,1H3,(H,23,24)(H,26,27)	ABTRFHMHQYVLFI-UHFFFAOYSA-N	767440	2-[6-(6-Methylpyridin-2-yl)-5- {thieno[3,2-c]pyridin-2-yl}- 1H,2H,3H-imidazo[1,2- a][1,3]diazol-2-yl]acetic acid::US20250270215, Example 21	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767440&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			170340928	522825938							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895672	CCN1CCn2c1nc(-c1cccc(C)n1)c2-c1ccc2ncnn2c1	InChI=1S/C19H19N7/c1-3-24-9-10-25-18(14-7-8-16-20-12-21-26(16)11-14)17(23-19(24)25)15-6-4-5-13(2)22-15/h4-8,11-12H,3,9-10H2,1-2H3	IUHQRIDTOBHMCC-UHFFFAOYSA-N	767441	6-(1-Ethyl-6-(6-methylpyridin-2-yl)- 2,3-dihydro-1H-imidazo[1,2- a]imidazol-5-yl)-[1,2,4]triazolo[1,5- a]pyridine::US20250270215, Example 22	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767441&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258783	522825939							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895673	CCOC(=O)C1Cn2c(nc(-c3cccc(C)n3)c2-c2ccc3ncnn3c2)N1	InChI=1S/C20H19N7O2/c1-3-29-19(28)15-10-26-18(13-7-8-16-21-11-22-27(16)9-13)17(25-20(26)24-15)14-6-4-5-12(2)23-14/h4-9,11,15H,3,10H2,1-2H3,(H,24,25)	WKTLVIOVJOHYMH-UHFFFAOYSA-N	767442	Ethyl 6-(6-methylpyridin-2-yl)-5- {[1,2,4]triazolo[1,5-a]pyridin-6-yl}- 1H,2H,3H-imidazo[1,2- a][1,3]diazole-2-carboxylate::US20250270215, Example 26	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767442&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			170340924	522825940							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895674	Cc1cccc(-c2nc3n(c2-c2cc4cnccc4s2)CC(C(=O)N(C)C)N3)n1	InChI=1S/C21H20N6OS/c1-12-5-4-6-14(23-12)18-19(17-9-13-10-22-8-7-16(13)29-17)27-11-15(20(28)26(2)3)24-21(27)25-18/h4-10,15H,11H2,1-3H3,(H,24,25)	BXIDGMABQFIDGF-UHFFFAOYSA-N	767443	N,N-Dimethyl-6-(6-methylpyridin- 2-yl)-5-{thieno[3,2-c]pyridin-2-yl}- 1H,2H,3H-imidazo[1,2- a][1,3]diazole-2-carboxamide::US20250270215, Example 29	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767443&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			170340964	522825941							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895675	Cc1cccc(-c2nc3n(c2-c2ccc4snnc4c2)CCN3)n1	InChI=1S/C17H14N6S/c1-10-3-2-4-12(19-10)15-16(23-8-7-18-17(23)20-15)11-5-6-14-13(9-11)21-22-24-14/h2-6,9H,7-8H2,1H3,(H,18,20)	UHHSWUXONPOAMN-UHFFFAOYSA-N	767444	5-(6-(6-Methylpyridin-2-yl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)benzo[d][1,2,3]thiadiazole::US20250270215, Example 30	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767444&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258787	522825942							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895676	Cc1cccc(-c2nc3n(c2-c2ccc4nnsc4c2)CCN3)n1	InChI=1S/C17H14N6S/c1-10-3-2-4-13(19-10)15-16(23-8-7-18-17(23)20-15)11-5-6-12-14(9-11)24-22-21-12/h2-6,9H,7-8H2,1H3,(H,18,20)	SMHGZJIIORDKGW-UHFFFAOYSA-N	767445	6-(6-(6-Methylpyridin-2-yl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)benzo[d][1,2,3 ]thiadiazole::US20250270215, Example 31	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767445&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258727	522825943							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895677	CCN1CCn2c1nc(-c1cccc(C)n1)c2-c1ccc2ncsc2c1	InChI=1S/C20H19N5S/c1-3-24-9-10-25-19(14-7-8-15-17(11-14)26-12-21-15)18(23-20(24)25)16-6-4-5-13(2)22-16/h4-8,11-12H,3,9-10H2,1-2H3	OIUGQPXKLNUSNI-UHFFFAOYSA-N	767446	6-[1-Ethyl-6-(6-methylpyridin-2-yl)- 1H,2H,3H-imidazo[1,2- a][1,3]diazol-5-yl]-1,3- benzothiazole::US20250270215, Example 33	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767446&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258682	522825944							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895678	Cc1cccc(-c2nc3n(c2-c2cncc4[nH]ccc24)CCN3)n1	InChI=1S/C18H16N6/c1-11-3-2-4-14(22-11)16-17(24-8-7-21-18(24)23-16)13-9-19-10-15-12(13)5-6-20-15/h2-6,9-10,20H,7-8H2,1H3,(H,21,23)	YDCWPRMKCDOXCG-UHFFFAOYSA-N	767447	4-(6-(6-Methylpyridin-2-yl)-2,3- dihydro-1H-imidazo[1,2-a]imidazol- 5-yl)-1H-pyrrolo[2,3-b ]pyridine::US20250270215, Example 35	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767447&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			176872114	522825945							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895679	CCN1CCn2c1nc(-c1cccc(C)n1)c2-c1cc2cnccc2s1	InChI=1S/C20H19N5S/c1-3-24-9-10-25-19(17-11-14-12-21-8-7-16(14)26-17)18(23-20(24)25)15-6-4-5-13(2)22-15/h4-8,11-12H,3,9-10H2,1-2H3	IESNUFLIRVIVJD-UHFFFAOYSA-N	767448	2-(1-Ethyl-5-{thieno[3,2-c]pyridin- 2-yl}-1H,2H,3H-imidazo[1,2- a][1,3]diazol-6-yl)-6-methylpyridine::US20250270215, Example 42	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767448&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			170340936	522825946							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895680	Cc1cccc(-c2nc3n(c2-c2ccc(F)c(N)c2)CCN3)n1	InChI=1S/C17H16FN5/c1-10-3-2-4-14(21-10)15-16(23-8-7-20-17(23)22-15)11-5-6-12(18)13(19)9-11/h2-6,9H,7-8,19H2,1H3,(H,20,22)	YUBJLRCEBMETKM-UHFFFAOYSA-N	767449	2-Fluoro-5-(6-(6-methylpyridin- 2-yl)-2,3-dihydro-1H- imidazo[1,2-a]imidazol-5- yl)aniline::US20250270215, Example 43	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767449&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258761	522825947							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895681	Cc1cccc(-c2nc3n(c2-c2ccc4nc(N)sc4c2)CCN3)n1	InChI=1S/C18H16N6S/c1-10-3-2-4-13(21-10)15-16(24-8-7-20-18(24)23-15)11-5-6-12-14(9-11)25-17(19)22-12/h2-6,9H,7-8H2,1H3,(H2,19,22)(H,20,23)	HNJYZCRQROVQJG-UHFFFAOYSA-N	767450	6-(6-(6-Methylpyridin-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]imidazol-5-yl)benzo[d] thiazol-2-amine::US20250270215, Example 48	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767450&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			169258666	522825948							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895682	Cc1cccc(-c2nc3n(c2-c2ccc(O)cc2)CCN3)n1	InChI=1S/C17H16N4O/c1-11-3-2-4-14(19-11)15-16(12-5-7-13(22)8-6-12)21-10-9-18-17(21)20-15/h2-8,22H,9-10H2,1H3,(H,18,20)	BAMWNHZNSZHHQN-UHFFFAOYSA-N	767451	4-[6-(6-Methylpyridin-2-yl)- 1H,2H,3H-imidazo[1,2- a][1,3]diazol-5-yl]phenol::US20250270215, Example 55	TGF-beta receptor type-1	Human		 3.00							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767451&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			170340925	522825949							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895683	Cc1cccc(-c2nc3n(c2-c2ccnc(N)c2)CCN3)n1	InChI=1S/C16H16N6/c1-10-3-2-4-12(20-10)14-15(11-5-6-18-13(17)9-11)22-8-7-19-16(22)21-14/h2-6,9H,7-8H2,1H3,(H2,17,18)(H,19,21)	ZYOHIJVVGCRSCU-UHFFFAOYSA-N	767452	4-[6-(6-Methylpyridin-2-yl)- 1H,2H,3H-imidazo[1,2- a][1,3]diazol-5-yl]pyridin-2-amine::US20250270215, Example 56	TGF-beta receptor type-1	Human		 7.50							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767452&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			170340944	522825950							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
895684	COc1cccc(-c2nc3n(c2-c2ccc4ncsc4c2)CCN3)n1	InChI=1S/C18H15N5OS/c1-24-15-4-2-3-13(21-15)16-17(23-8-7-19-18(23)22-16)11-5-6-12-14(9-11)25-10-20-12/h2-6,9-10H,7-8H2,1H3,(H,19,22)	HMXKPOFMTQUZEF-UHFFFAOYSA-N	767453	6-[6-(6-Methoxypyridin-2-yl)- 1H,2H,3H-imidazo[1,2- a][1,3]diazol-5-yl]-1,3- benzothiazole::US20250270215, Example 57	TGF-beta receptor type-1	Human		<1.000							US Patent		10.7270/Q29K4H00			US20250270215	PIZZIRANI, D; RONCHI, P; BIAGETTI, M; GUARIENTO, S; PALA, D	8/28/2025	12/9/2025	Chiesi Farmaceutici	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=767453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=750&target=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=767453&enzyme=TGF-beta+receptor+type-1&column=ki&startPg=0&Increment=50&submit=Search			170340974	522825951							1	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM	3KCF,3FAA,2X7O,1IAS,1B6C,8YHF,1PY5,9J9D,3TZM,4X2N,4X2K,4X2J,4X2G,4X2F,4X0M,8YHL,5QIM,5E8S,2WOU,2WOT,6B8Y,5QU0,5QTZ,5QIL,5QIK,5E8Z,5E8W,5E8T,3HMM,3GXL,1VJY,1RW8,9F6X,5USQ,5FRI,3KFD,6MAC	TGF-beta receptor type-1	TGFR1_HUMAN	P36897	Q6IR47 Q706C0 Q706C1