BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 979404 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2Cc3cc(F)cc1c3O2 InChI=1S/C18H16FN5O2/c1-9-13-6-11(19)4-10-5-12(26-16(10)13)7-20-18(25)14-8-21-24-3-2-15(22-9)23-17(14)24/h2-4,6,8-9,12H,5,7H2,1H3,(H,20,25)(H,22,23) SSEZULRYZRTZPF-UHFFFAOYSA-N 769494 (3R)-6-fluoro-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 1 High affinity nerve growth factor receptor Human 1.66 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769494&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324022 522827992 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979405 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2Cc3cc(F)cc1c3O2 InChI=1S/C18H16FN5O2/c1-9-13-6-11(19)4-10-5-12(26-16(10)13)7-20-18(25)14-8-21-24-3-2-15(22-9)23-17(14)24/h2-4,6,8-9,12H,5,7H2,1H3,(H,20,25)(H,22,23) SSEZULRYZRTZPF-UHFFFAOYSA-N 769494 (3R)-6-fluoro-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 1 BDNF/NT-3 growth factors receptor Human 0.290 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769494&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324022 522827992 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 979406 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2Cc3cc(F)cc1c3O2 InChI=1S/C18H16FN5O2/c1-9-13-6-11(19)4-10-5-12(26-16(10)13)7-20-18(25)14-8-21-24-3-2-15(22-9)23-17(14)24/h2-4,6,8-9,12H,5,7H2,1H3,(H,20,25)(H,22,23) SSEZULRYZRTZPF-UHFFFAOYSA-N 769494 (3R)-6-fluoro-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 1 NT-3 growth factor receptor Human 0.500 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769494&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324022 522827992 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979407 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2Cc3cc(F)cc1c3O2 InChI=1S/C18H16FN5O2/c1-9-13-6-11(19)4-10-5-12(26-16(10)13)7-20-18(25)14-8-21-24-3-2-15(22-9)23-17(14)24/h2-4,6,8-9,12H,5,7H2,1H3,(H,20,25)(H,22,23) SSEZULRYZRTZPF-UHFFFAOYSA-N 769494 (3R)-6-fluoro-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 1 High affinity nerve growth factor receptor [G595R] Human 11.3 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769494&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324022 522827992 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979408 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC[C@H]2Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-14-8-12(20)6-11-7-13(27-17(11)14)2-4-21-19(26)15-9-22-25-5-3-16(23-10)24-18(15)25/h3,5-6,8-10,13H,2,4,7H2,1H3,(H,21,26)(H,23,24) RFSSOUGNOQIPBG-UHFFFAOYSA-N 769495 (3R,11R)-6-fluoro-3-methyl-10-oxa-2,14,18,19,22- pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa- 1(22),4,6,8,16(23),17,20-heptaen-15-one::US12410191, Example 3 High affinity nerve growth factor receptor Human 1.70 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769495&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324107 522827993 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979409 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC[C@H]2Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-14-8-12(20)6-11-7-13(27-17(11)14)2-4-21-19(26)15-9-22-25-5-3-16(23-10)24-18(15)25/h3,5-6,8-10,13H,2,4,7H2,1H3,(H,21,26)(H,23,24) RFSSOUGNOQIPBG-UHFFFAOYSA-N 769495 (3R,11R)-6-fluoro-3-methyl-10-oxa-2,14,18,19,22- pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa- 1(22),4,6,8,16(23),17,20-heptaen-15-one::US12410191, Example 3 BDNF/NT-3 growth factors receptor Human 0.330 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769495&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324107 522827993 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 979410 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC[C@H]2Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-14-8-12(20)6-11-7-13(27-17(11)14)2-4-21-19(26)15-9-22-25-5-3-16(23-10)24-18(15)25/h3,5-6,8-10,13H,2,4,7H2,1H3,(H,21,26)(H,23,24) RFSSOUGNOQIPBG-UHFFFAOYSA-N 769495 (3R,11R)-6-fluoro-3-methyl-10-oxa-2,14,18,19,22- pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa- 1(22),4,6,8,16(23),17,20-heptaen-15-one::US12410191, Example 3 NT-3 growth factor receptor Human 0.470 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769495&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324107 522827993 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979411 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC[C@H]2Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-14-8-12(20)6-11-7-13(27-17(11)14)2-4-21-19(26)15-9-22-25-5-3-16(23-10)24-18(15)25/h3,5-6,8-10,13H,2,4,7H2,1H3,(H,21,26)(H,23,24) RFSSOUGNOQIPBG-UHFFFAOYSA-N 769495 (3R,11R)-6-fluoro-3-methyl-10-oxa-2,14,18,19,22- pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa- 1(22),4,6,8,16(23),17,20-heptaen-15-one::US12410191, Example 3 High affinity nerve growth factor receptor [G595R] Human 3.31 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769495&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324107 522827993 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979412 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769496 (3R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 5 High affinity nerve growth factor receptor Human 0.920 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769496&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324109 522827994 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979413 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769496 (3R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 5 BDNF/NT-3 growth factors receptor Human 0.760 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769496&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324109 522827994 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 979414 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769496 (3R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 5 NT-3 growth factor receptor Human 2.63 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769496&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324109 522827994 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979415 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769496 (3R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 5 High affinity nerve growth factor receptor [G595R] Human 4.31 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769496&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324109 522827994 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979416 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769496 (3R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 5 NT-3 growth factor receptor [G623R] Homo sapiens (Human) 14.5 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2028&target=NT-3+growth+factor+receptor+%5BG623R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769496&enzyme=NT-3+growth+factor+receptor+%5BG623R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324109 522827994 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHRDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979417 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCCc2cc3cc(F)cc1c3o2 InChI=1S/C19H16FN5O2/c1-10-14-8-12(20)6-11-7-13(27-17(11)14)2-4-21-19(26)15-9-22-25-5-3-16(23-10)24-18(15)25/h3,5-10H,2,4H2,1H3,(H,21,26)(H,23,24) CDDGGDMFHAHNMC-UHFFFAOYSA-N 769497 (3R)-6-fluoro-3-methyl-10-oxa-2,14,18,19,22-pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa-1(22),4,6,8,11(24),16::US12410191, Example 6 High affinity nerve growth factor receptor Human 1.05 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769497 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769497&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324106 522827995 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979418 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCCc2cc3cc(F)cc1c3o2 InChI=1S/C19H16FN5O2/c1-10-14-8-12(20)6-11-7-13(27-17(11)14)2-4-21-19(26)15-9-22-25-5-3-16(23-10)24-18(15)25/h3,5-10H,2,4H2,1H3,(H,21,26)(H,23,24) CDDGGDMFHAHNMC-UHFFFAOYSA-N 769497 (3R)-6-fluoro-3-methyl-10-oxa-2,14,18,19,22-pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa-1(22),4,6,8,11(24),16::US12410191, Example 6 BDNF/NT-3 growth factors receptor Human 0.340 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769497 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769497&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324106 522827995 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 979419 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCCc2cc3cc(F)cc1c3o2 InChI=1S/C19H16FN5O2/c1-10-14-8-12(20)6-11-7-13(27-17(11)14)2-4-21-19(26)15-9-22-25-5-3-16(23-10)24-18(15)25/h3,5-10H,2,4H2,1H3,(H,21,26)(H,23,24) CDDGGDMFHAHNMC-UHFFFAOYSA-N 769497 (3R)-6-fluoro-3-methyl-10-oxa-2,14,18,19,22-pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa-1(22),4,6,8,11(24),16::US12410191, Example 6 High affinity nerve growth factor receptor [G595R] Human 11.3 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769497 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769497&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324106 522827995 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979420 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@H]2COc3cc(F)cc1c3O2 InChI=1S/C18H16FN5O3/c1-9-12-4-10(19)5-14-16(12)27-11(8-26-14)6-20-18(25)13-7-21-24-3-2-15(22-9)23-17(13)24/h2-5,7,9,11H,6,8H2,1H3,(H,20,25)(H,22,23) SNEMCZIOBDJWLQ-UHFFFAOYSA-N 769499 (2R,14R)-19-fluoro-2-methyl-16,22-dioxa-3,5,7,8,12-pentaazapentacyclo[12.6.2.24,7.06,10.017,21]tetracosa-1(20),4,6(10),8,17::US12410191, Example 7 High affinity nerve growth factor receptor Human 2.05 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769499 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769499&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324098 522827997 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979421 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@H]2COc3cc(F)cc1c3O2 InChI=1S/C18H16FN5O3/c1-9-12-4-10(19)5-14-16(12)27-11(8-26-14)6-20-18(25)13-7-21-24-3-2-15(22-9)23-17(13)24/h2-5,7,9,11H,6,8H2,1H3,(H,20,25)(H,22,23) SNEMCZIOBDJWLQ-UHFFFAOYSA-N 769499 (2R,14R)-19-fluoro-2-methyl-16,22-dioxa-3,5,7,8,12-pentaazapentacyclo[12.6.2.24,7.06,10.017,21]tetracosa-1(20),4,6(10),8,17::US12410191, Example 7 BDNF/NT-3 growth factors receptor Human 0.320 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769499 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769499&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324098 522827997 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 979422 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@H]2COc3cc(F)cc1c3O2 InChI=1S/C18H16FN5O3/c1-9-12-4-10(19)5-14-16(12)27-11(8-26-14)6-20-18(25)13-7-21-24-3-2-15(22-9)23-17(13)24/h2-5,7,9,11H,6,8H2,1H3,(H,20,25)(H,22,23) SNEMCZIOBDJWLQ-UHFFFAOYSA-N 769499 (2R,14R)-19-fluoro-2-methyl-16,22-dioxa-3,5,7,8,12-pentaazapentacyclo[12.6.2.24,7.06,10.017,21]tetracosa-1(20),4,6(10),8,17::US12410191, Example 7 High affinity nerve growth factor receptor [G595R] Human 2.65 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769499 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769499&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324098 522827997 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979423 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@H]2COc3cc(F)cc1c3O2 InChI=1S/C18H16FN5O3/c1-9-12-4-10(19)5-14-16(12)27-11(8-26-14)6-20-18(25)13-7-21-24-3-2-15(22-9)23-17(13)24/h2-5,7,9,11H,6,8H2,1H3,(H,20,25)(H,22,23) SNEMCZIOBDJWLQ-UHFFFAOYSA-N 769499 (2R,14R)-19-fluoro-2-methyl-16,22-dioxa-3,5,7,8,12-pentaazapentacyclo[12.6.2.24,7.06,10.017,21]tetracosa-1(20),4,6(10),8,17::US12410191, Example 7 High affinity nerve growth factor receptor [G667C] Human 21.1 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769499 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=963&target=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769499&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search 155324098 522827997 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979424 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@H]2COc3cc(F)cc1c3O2 InChI=1S/C18H16FN5O3/c1-9-12-4-10(19)5-14-16(12)27-11(8-26-14)6-20-18(25)13-7-21-24-3-2-15(22-9)23-17(13)24/h2-5,7,9,11H,6,8H2,1H3,(H,20,25)(H,22,23) SNEMCZIOBDJWLQ-UHFFFAOYSA-N 769499 (2R,14R)-19-fluoro-2-methyl-16,22-dioxa-3,5,7,8,12-pentaazapentacyclo[12.6.2.24,7.06,10.017,21]tetracosa-1(20),4,6(10),8,17::US12410191, Example 7 NT-3 growth factor receptor [G623R] Homo sapiens (Human) 25.3 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769499 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2028&target=NT-3+growth+factor+receptor+%5BG623R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769499&enzyme=NT-3+growth+factor+receptor+%5BG623R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324098 522827997 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHRDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979425 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 High affinity nerve growth factor receptor Human 0.560 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979426 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 BDNF/NT-3 growth factors receptor Human 0.450 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 979427 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 NT-3 growth factor receptor Human 0.220 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979428 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 High affinity nerve growth factor receptor [G595R] Human 2.03 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979429 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 NT-3 growth factor receptor [G623R] Homo sapiens (Human) 13.5 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2028&target=NT-3+growth+factor+receptor+%5BG623R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=NT-3+growth+factor+receptor+%5BG623R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHRDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979430 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@]2(C)Cc3cc(F)c(F)c1c3O2 InChI=1S/C19H17F2N5O2/c1-9-14-15(21)12(20)5-10-6-19(2,28-16(10)14)8-22-18(27)11-7-23-26-4-3-13(24-9)25-17(11)26/h3-5,7,9H,6,8H2,1-2H3,(H,22,27)(H,24,25) JAKWBQOCOJPWEX-UHFFFAOYSA-N 769501 (3R,11S)-5,6-difluoro-3,11-dimethyl-10-oxa-2,13,17, 18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22] tricosa-1(21),4,6,8,15(22),16,19-heptaen-14-one::US12410191, Example 11 High affinity nerve growth factor receptor Human 4.50 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769501 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769501&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324068 522827999 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979431 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@]2(C)Cc3cc(F)c(F)c1c3O2 InChI=1S/C19H17F2N5O2/c1-9-14-15(21)12(20)5-10-6-19(2,28-16(10)14)8-22-18(27)11-7-23-26-4-3-13(24-9)25-17(11)26/h3-5,7,9H,6,8H2,1-2H3,(H,22,27)(H,24,25) JAKWBQOCOJPWEX-UHFFFAOYSA-N 769501 (3R,11S)-5,6-difluoro-3,11-dimethyl-10-oxa-2,13,17, 18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22] tricosa-1(21),4,6,8,15(22),16,19-heptaen-14-one::US12410191, Example 11 NT-3 growth factor receptor Human 0.630 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769501 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769501&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324068 522827999 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979432 COC[C@@]12CNC(=O)c3cnn4ccc(nc34)N[C@H](C)c3cc(F)cc(c3O1)C2 InChI=1S/C20H20FN5O3/c1-11-14-6-13(21)5-12-7-20(10-28-2,29-17(12)14)9-22-19(27)15-8-23-26-4-3-16(24-11)25-18(15)26/h3-6,8,11H,7,9-10H2,1-2H3,(H,22,27)(H,24,25) ZBTADFYRGPHVEO-UHFFFAOYSA-N 769502 (3R,11R)-6-fluoro-11-(methoxymethyl)-3-methyl- 10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11. 04,9.018,22]tricosa-1(21),4,6,8,15(22),16,19-heptaen- 14-one::US12410191, Example 15 High affinity nerve growth factor receptor Human 2.80 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769502 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769502&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324147 522828000 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979433 COC[C@@]12CNC(=O)c3cnn4ccc(nc34)N[C@H](C)c3cc(F)cc(c3O1)C2 InChI=1S/C20H20FN5O3/c1-11-14-6-13(21)5-12-7-20(10-28-2,29-17(12)14)9-22-19(27)15-8-23-26-4-3-16(24-11)25-18(15)26/h3-6,8,11H,7,9-10H2,1-2H3,(H,22,27)(H,24,25) ZBTADFYRGPHVEO-UHFFFAOYSA-N 769502 (3R,11R)-6-fluoro-11-(methoxymethyl)-3-methyl- 10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11. 04,9.018,22]tricosa-1(21),4,6,8,15(22),16,19-heptaen- 14-one::US12410191, Example 15 NT-3 growth factor receptor Human 0.370 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769502 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769502&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324147 522828000 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979434 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(CF)Cc3cc(F)cc1c3O2 InChI=1S/C19H17F2N5O2/c1-10-13-5-12(21)4-11-6-19(8-20,28-16(11)13)9-22-18(27)14-7-23-26-3-2-15(24-10)25-17(14)26/h2-5,7,10H,6,8-9H2,1H3,(H,22,27)(H,24,25) WGPVINKDZIUGSE-UHFFFAOYSA-N 769503 (3R)-6-fluoro-11-(fluoromethyl)-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 18 High affinity nerve growth factor receptor Human 0.630 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769503&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324294 522828001 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 979435 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(CF)Cc3cc(F)cc1c3O2 InChI=1S/C19H17F2N5O2/c1-10-13-5-12(21)4-11-6-19(8-20,28-16(11)13)9-22-18(27)14-7-23-26-3-2-15(24-10)25-17(14)26/h2-5,7,10H,6,8-9H2,1H3,(H,22,27)(H,24,25) WGPVINKDZIUGSE-UHFFFAOYSA-N 769503 (3R)-6-fluoro-11-(fluoromethyl)-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 18 BDNF/NT-3 growth factors receptor Human 0.170 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769503&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324294 522828001 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 979436 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(CF)Cc3cc(F)cc1c3O2 InChI=1S/C19H17F2N5O2/c1-10-13-5-12(21)4-11-6-19(8-20,28-16(11)13)9-22-18(27)14-7-23-26-3-2-15(24-10)25-17(14)26/h2-5,7,10H,6,8-9H2,1H3,(H,22,27)(H,24,25) WGPVINKDZIUGSE-UHFFFAOYSA-N 769503 (3R)-6-fluoro-11-(fluoromethyl)-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 18 NT-3 growth factor receptor Human 1.37 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769503&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324294 522828001 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 979437 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(CF)Cc3cc(F)cc1c3O2 InChI=1S/C19H17F2N5O2/c1-10-13-5-12(21)4-11-6-19(8-20,28-16(11)13)9-22-18(27)14-7-23-26-3-2-15(24-10)25-17(14)26/h2-5,7,10H,6,8-9H2,1H3,(H,22,27)(H,24,25) WGPVINKDZIUGSE-UHFFFAOYSA-N 769503 (3R)-6-fluoro-11-(fluoromethyl)-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 18 High affinity nerve growth factor receptor [G595R] Human 3.90 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769503&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324294 522828001 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984318 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(CF)Cc3cc(F)cc1c3O2 InChI=1S/C19H17F2N5O2/c1-10-13-5-12(21)4-11-6-19(8-20,28-16(11)13)9-22-18(27)14-7-23-26-3-2-15(24-10)25-17(14)26/h2-5,7,10H,6,8-9H2,1H3,(H,22,27)(H,24,25) WGPVINKDZIUGSE-UHFFFAOYSA-N 769503 (3R)-6-fluoro-11-(fluoromethyl)-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 18 High affinity nerve growth factor receptor [G667C] Human 6.11 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=963&target=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769503&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search 155324294 522828001 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984319 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(CO)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O3/c1-10-13-5-12(20)4-11-6-19(9-26,28-16(11)13)8-21-18(27)14-7-22-25-3-2-15(23-10)24-17(14)25/h2-5,7,10,26H,6,8-9H2,1H3,(H,21,27)(H,23,24) RKIKBHDFIWQGHL-UHFFFAOYSA-N 769504 (3R)-6-fluoro-11-(hydroxymethyl)-3-methyl-10-oxa- 2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9. 018,22]tricosa-1(21),4,6,8,15(22),16,19-heptaen-14- one::US12410191, Example 19 High affinity nerve growth factor receptor Human 3.40 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769504 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769504&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324293 522828002 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984320 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(CO)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O3/c1-10-13-5-12(20)4-11-6-19(9-26,28-16(11)13)8-21-18(27)14-7-22-25-3-2-15(23-10)24-17(14)25/h2-5,7,10,26H,6,8-9H2,1H3,(H,21,27)(H,23,24) RKIKBHDFIWQGHL-UHFFFAOYSA-N 769504 (3R)-6-fluoro-11-(hydroxymethyl)-3-methyl-10-oxa- 2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9. 018,22]tricosa-1(21),4,6,8,15(22),16,19-heptaen-14- one::US12410191, Example 19 BDNF/NT-3 growth factors receptor Human 0.250 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769504 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769504&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324293 522828002 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 984321 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(CO)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O3/c1-10-13-5-12(20)4-11-6-19(9-26,28-16(11)13)8-21-18(27)14-7-22-25-3-2-15(23-10)24-17(14)25/h2-5,7,10,26H,6,8-9H2,1H3,(H,21,27)(H,23,24) RKIKBHDFIWQGHL-UHFFFAOYSA-N 769504 (3R)-6-fluoro-11-(hydroxymethyl)-3-methyl-10-oxa- 2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9. 018,22]tricosa-1(21),4,6,8,15(22),16,19-heptaen-14- one::US12410191, Example 19 NT-3 growth factor receptor Human 1.16 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769504 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769504&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324293 522828002 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 984322 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(CO)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O3/c1-10-13-5-12(20)4-11-6-19(9-26,28-16(11)13)8-21-18(27)14-7-22-25-3-2-15(23-10)24-17(14)25/h2-5,7,10,26H,6,8-9H2,1H3,(H,21,27)(H,23,24) RKIKBHDFIWQGHL-UHFFFAOYSA-N 769504 (3R)-6-fluoro-11-(hydroxymethyl)-3-methyl-10-oxa- 2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9. 018,22]tricosa-1(21),4,6,8,15(22),16,19-heptaen-14- one::US12410191, Example 19 High affinity nerve growth factor receptor [G595R] Human 19.3 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769504 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769504&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324293 522828002 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984323 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C20H20FN5O2/c1-11-14-8-13(21)7-12-9-20(2,28-17(12)14)4-5-22-19(27)15-10-23-26-6-3-16(24-11)25-18(15)26/h3,6-8,10-11H,4-5,9H2,1-2H3,(H,22,27)(H,24,25) YYTRBKAQWLOPAP-UHFFFAOYSA-N 769505 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,14,18,19,22-pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa-1(22),4,6,8,16::US12410191, Example 20 High affinity nerve growth factor receptor Human 5.90 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769505 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769505&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 163204531 522828003 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984324 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C20H20FN5O2/c1-11-14-8-13(21)7-12-9-20(2,28-17(12)14)4-5-22-19(27)15-10-23-26-6-3-16(24-11)25-18(15)26/h3,6-8,10-11H,4-5,9H2,1-2H3,(H,22,27)(H,24,25) YYTRBKAQWLOPAP-UHFFFAOYSA-N 769505 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,14,18,19,22-pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa-1(22),4,6,8,16::US12410191, Example 20 High affinity nerve growth factor receptor [G667C] Human 4.20 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769505 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=963&target=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769505&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search 163204531 522828003 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984325 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC[C@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C20H20FN5O2/c1-11-14-8-13(21)7-12-9-20(2,28-17(12)14)4-5-22-19(27)15-10-23-26-6-3-16(24-11)25-18(15)26/h3,6-8,10-11H,4-5,9H2,1-2H3,(H,22,27)(H,24,25) YYTRBKAQWLOPAP-UHFFFAOYSA-N 769506 (3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,14,18,19,22-pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa-1(22),4,6,8,16::US12410191, Example 21 High affinity nerve growth factor receptor Human 18.5 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769506 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769506&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324295 522828004 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984326 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC[C@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C20H20FN5O2/c1-11-14-8-13(21)7-12-9-20(2,28-17(12)14)4-5-22-19(27)15-10-23-26-6-3-16(24-11)25-18(15)26/h3,6-8,10-11H,4-5,9H2,1-2H3,(H,22,27)(H,24,25) YYTRBKAQWLOPAP-UHFFFAOYSA-N 769506 (3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,14,18,19,22-pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa-1(22),4,6,8,16::US12410191, Example 21 High affinity nerve growth factor receptor [G667C] Human 24.6 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769506 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=963&target=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769506&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search 155324295 522828004 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984327 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(Cl)cc1c3O2 InChI=1S/C19H18ClN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AGHGCWANYKXNGS-UHFFFAOYSA-N 769507 (3R)-6-chloro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.011,22]tricosa-1(21),4,6,8,15::US12410191, Example 22 High affinity nerve growth factor receptor Human 0.980 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769507&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324292 522828005 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984328 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(Cl)cc1c3O2 InChI=1S/C19H18ClN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AGHGCWANYKXNGS-UHFFFAOYSA-N 769507 (3R)-6-chloro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.011,22]tricosa-1(21),4,6,8,15::US12410191, Example 22 BDNF/NT-3 growth factors receptor Human 0.360 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769507&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324292 522828005 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 984329 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(Cl)cc1c3O2 InChI=1S/C19H18ClN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AGHGCWANYKXNGS-UHFFFAOYSA-N 769507 (3R)-6-chloro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.011,22]tricosa-1(21),4,6,8,15::US12410191, Example 22 NT-3 growth factor receptor Human 0.520 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769507&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324292 522828005 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 984330 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(Cl)cc1c3O2 InChI=1S/C19H18ClN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AGHGCWANYKXNGS-UHFFFAOYSA-N 769507 (3R)-6-chloro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.011,22]tricosa-1(21),4,6,8,15::US12410191, Example 22 High affinity nerve growth factor receptor [G595R] Human 4.97 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769507&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324292 522828005 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984331 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(Cl)cc1c3O2 InChI=1S/C19H18ClN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AGHGCWANYKXNGS-UHFFFAOYSA-N 769507 (3R)-6-chloro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.011,22]tricosa-1(21),4,6,8,15::US12410191, Example 22 High affinity nerve growth factor receptor [G667C] Human 4.60 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=963&target=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769507&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search 155324292 522828005 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984332 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NCC2(C)Cc3cc(Cl)cc1c3O2 InChI=1S/C19H18ClN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AGHGCWANYKXNGS-UHFFFAOYSA-N 769507 (3R)-6-chloro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.011,22]tricosa-1(21),4,6,8,15::US12410191, Example 22 NT-3 growth factor receptor [G623R] Homo sapiens (Human) 7.40 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2028&target=NT-3+growth+factor+receptor+%5BG623R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769507&enzyme=NT-3+growth+factor+receptor+%5BG623R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324292 522828005 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHRDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 984333 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@]2(C)COc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O3/c1-10-12-5-11(20)6-14-16(12)28-19(2,9-27-14)8-21-18(26)13-7-22-25-4-3-15(23-10)24-17(13)25/h3-7,10H,8-9H2,1-2H3,(H,21,26)(H,23,24) XSZDEBORWVTPOT-UHFFFAOYSA-N 769508 (2R,14R)-19-fluoro-2,14-dimethyl-16,22-dioxa-3,5, 7,8,12-pentaazapentacyclo[12.6.2.24,7.06,10.017,21] tetracosa-1(20),4,6(10),8,17(21),18,23-heptaen-11-one::US12410191, Example 23 High affinity nerve growth factor receptor Human 4.83 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769508 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769508&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324133 522828006 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984334 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@]2(C)COc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O3/c1-10-12-5-11(20)6-14-16(12)28-19(2,9-27-14)8-21-18(26)13-7-22-25-4-3-15(23-10)24-17(13)25/h3-7,10H,8-9H2,1-2H3,(H,21,26)(H,23,24) XSZDEBORWVTPOT-UHFFFAOYSA-N 769508 (2R,14R)-19-fluoro-2,14-dimethyl-16,22-dioxa-3,5, 7,8,12-pentaazapentacyclo[12.6.2.24,7.06,10.017,21] tetracosa-1(20),4,6(10),8,17(21),18,23-heptaen-11-one::US12410191, Example 23 High affinity nerve growth factor receptor [G595R] Human 15.3 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769508 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769508&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324133 522828006 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984335 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 High affinity nerve growth factor receptor Human 0.820 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984336 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 BDNF/NT-3 growth factors receptor Human 1.17 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 984337 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 NT-3 growth factor receptor Human 0.700 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 984338 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 High affinity nerve growth factor receptor [G595R] Human 5.40 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984339 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 High affinity nerve growth factor receptor [G667C] Human 9.50 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=963&target=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984340 C[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-17(11)13)9-22-18(26)14-8-21-16-4-3-15(23-10)24-25(14)16/h3-6,8,10H,7,9H2,1-2H3,(H,22,26)(H,23,24) PNBULRZVGIVARS-UHFFFAOYSA-N 769510 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,21,22-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1::US12410191, Example 26 High affinity nerve growth factor receptor Human 0.970 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769510&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324118 522828008 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984341 C[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-17(11)13)9-22-18(26)14-8-21-16-4-3-15(23-10)24-25(14)16/h3-6,8,10H,7,9H2,1-2H3,(H,22,26)(H,23,24) PNBULRZVGIVARS-UHFFFAOYSA-N 769510 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,21,22-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1::US12410191, Example 26 BDNF/NT-3 growth factors receptor Human 1.30 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769510&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324118 522828008 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 984342 C[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-17(11)13)9-22-18(26)14-8-21-16-4-3-15(23-10)24-25(14)16/h3-6,8,10H,7,9H2,1-2H3,(H,22,26)(H,23,24) PNBULRZVGIVARS-UHFFFAOYSA-N 769510 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,21,22-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1::US12410191, Example 26 NT-3 growth factor receptor Human 0.800 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769510&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324118 522828008 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 984343 C[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-17(11)13)9-22-18(26)14-8-21-16-4-3-15(23-10)24-25(14)16/h3-6,8,10H,7,9H2,1-2H3,(H,22,26)(H,23,24) PNBULRZVGIVARS-UHFFFAOYSA-N 769510 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,21,22-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1::US12410191, Example 26 High affinity nerve growth factor receptor [G595R] Human 8.60 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1101&target=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769510&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG595R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324118 522828008 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,4AOJ,5H3Q,5WR7,8J5X,7VKN,7VKM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984344 C[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-17(11)13)9-22-18(26)14-8-21-16-4-3-15(23-10)24-25(14)16/h3-6,8,10H,7,9H2,1-2H3,(H,22,26)(H,23,24) PNBULRZVGIVARS-UHFFFAOYSA-N 769510 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,21,22-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1::US12410191, Example 26 High affinity nerve growth factor receptor [G667C] Human 15.5 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=963&target=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769510&enzyme=High+affinity+nerve+growth+factor+receptor+%5BG667C%5D&column=ki&startPg=0&Increment=50&submit=Search 155324118 522828008 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 984345 C[C@H]1CNC(=O)c2cnn3c2nc(cc3)N[C@@H](c4cc(ccc4O1)F)C InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23) FIKPXCOQUIZNHB-UHFFFAOYSA-N 374727 US10246466, Example 93::(7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrahydro-1,15-ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)- one::US10618912, Example 93::US11291667, Compound 1::US12129258, Example TPX-0005::US12410191, Example repotrectinib ALK tyrosine kinase receptor Human 9.45 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=374727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=374727&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 7GI 7VKN,7VKO 135565923 404343787 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 984346 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 ALK tyrosine kinase receptor Human 2.02 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 984347 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 ALK tyrosine kinase receptor Human 1.93 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 984348 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 ALK tyrosine kinase receptor [G1202R] Human 13.2 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1538&target=ALK+tyrosine+kinase+receptor+%5BG1202R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=ALK+tyrosine+kinase+receptor+%5BG1202R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGRDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,7NWZ,5FTQ,5FTO,2XBA,2XB7,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 984349 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 ALK tyrosine kinase receptor [L1196M,G1202R] Homo sapiens (Human) 20.7 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2031&target=ALK+tyrosine+kinase+receptor+%5BL1196M%2CG1202R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=ALK+tyrosine+kinase+receptor+%5BL1196M%2CG1202R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILMELMAGRDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,9GBE,7NWZ,4FNY,4FNX,4FNW,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 984350 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 ALK tyrosine kinase receptor [G1202R] Human 13.6 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1538&target=ALK+tyrosine+kinase+receptor+%5BG1202R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=ALK+tyrosine+kinase+receptor+%5BG1202R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGRDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,7NWZ,5FTQ,5FTO,2XBA,2XB7,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 984351 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 ALK tyrosine kinase receptor [L1196M,G1202R] Homo sapiens (Human) 24.2 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2031&target=ALK+tyrosine+kinase+receptor+%5BL1196M%2CG1202R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=ALK+tyrosine+kinase+receptor+%5BL1196M%2CG1202R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILMELMAGRDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,9GBE,7NWZ,4FNY,4FNX,4FNW,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 984352 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 Proto-oncogene tyrosine-protein kinase ROS Human 0.360 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6479&target=Proto-oncogene+tyrosine-protein+kinase+ROS&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=Proto-oncogene+tyrosine-protein+kinase+ROS&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD 7Z5X,7Z5W Proto-oncogene tyrosine-protein kinase ROS ROS1_HUMAN P08922 Q15368 Q5TDB5 984353 C[C@H]1Nc2ccn3ncc(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H18FN5O2/c1-10-13-6-12(20)5-11-7-19(2,27-16(11)13)9-21-18(26)14-8-22-25-4-3-15(23-10)24-17(14)25/h3-6,8,10H,7,9H2,1-2H3,(H,21,26)(H,23,24) AKARKHHDGYZKIF-UHFFFAOYSA-N 769500 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 8 Proto-oncogene tyrosine-protein kinase ROS [G2032R] Human 0.340 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=882&target=Proto-oncogene+tyrosine-protein+kinase+ROS+%5BG2032R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769500&enzyme=Proto-oncogene+tyrosine-protein+kinase+ROS+%5BG2032R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324104 522827998 1 MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGRDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD 9QEK Proto-oncogene tyrosine-protein kinase ROS ROS1_HUMAN P08922 Q15368 Q5TDB5 984354 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 Proto-oncogene tyrosine-protein kinase ROS Human 0.840 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6479&target=Proto-oncogene+tyrosine-protein+kinase+ROS&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=Proto-oncogene+tyrosine-protein+kinase+ROS&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD 7Z5X,7Z5W Proto-oncogene tyrosine-protein kinase ROS ROS1_HUMAN P08922 Q15368 Q5TDB5 984355 C[C@H]1Nc2ccn3nc(N)c(c3n2)C(=O)NC[C@@]2(C)Cc3cc(F)cc1c3O2 InChI=1S/C19H19FN6O2/c1-9-12-6-11(20)5-10-7-19(2,28-15(10)12)8-22-18(27)14-16(21)25-26-4-3-13(23-9)24-17(14)26/h3-6,9H,7-8H2,1-2H3,(H2,21,25)(H,22,27)(H,23,24) OHIKHZFSGQMGGD-UHFFFAOYSA-N 769509 (3R,11R)-16-amino-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15::US12410191, Example 25 Proto-oncogene tyrosine-protein kinase ROS [G2032R] Human 2.11 US Patent 10.7270/Q27M0DQC US12410191 Chen, Y; Gong, L; Zhu, X; Xiang, Q; Mao, W; Ye, C; Hu, T; Chen, L; Jiang, G 9/9/2025 12/17/2025 Zhejiang Hisun Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=769509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=882&target=Proto-oncogene+tyrosine-protein+kinase+ROS+%5BG2032R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=769509&enzyme=Proto-oncogene+tyrosine-protein+kinase+ROS+%5BG2032R%5D&column=ki&startPg=0&Increment=50&submit=Search 155324173 522828007 1 MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGRDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD 9QEK Proto-oncogene tyrosine-protein kinase ROS ROS1_HUMAN P08922 Q15368 Q5TDB5