BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
1094790	COc1nn(C)cc1-c1[nH]c2ncc3c(c2c1-c1ccc2c(cnn2C)c1)n(C1CCOCC1)c(=O)n3C			771614	US20250092044, Comparative Example A	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771614&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			162432490	523184284							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094791	COc1nn(C)cc1-c1[nH]c2ncc3c(c2c1-c1ccc2c(cnn2C)c1)n(C1CCOCC1)c(=O)n3C			771614	US20250092044, Comparative Example A	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771614&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			162432490	523184284							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094792	COc1nn(C)cc1-c1[nH]c2ncc3c(c2c1-c1ccc2c(cnn2C)c1)n(C1CCOCC1)c(=O)n3C			771614	US20250092044, Comparative Example A	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771614&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			162432490	523184284							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094793	COc1nn(C)cc1-c1[nH]c2ncc3c(c2c1-c1ccc2c(cnn2C)c1)n(C1CCOCC1)c(=O)n3C			771614	US20250092044, Comparative Example A	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771614&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			162432490	523184284							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094794	[2H]C([2H])([2H])n1ncc2cc(-c3c(-c4cn(C)nc4OC)[nH]c4ncc5c(c34)n(C3CCOCC3)c(=O)n5C)ccc21			771615	US20250092044, Comparative Example B	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771615&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			162432541	523184285							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094795	[2H]C([2H])([2H])n1ncc2cc(-c3c(-c4cn(C)nc4OC)[nH]c4ncc5c(c34)n(C3CCOCC3)c(=O)n5C)ccc21			771615	US20250092044, Comparative Example B	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771615&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			162432541	523184285							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094796	[2H]C([2H])([2H])n1ncc2cc(-c3c(-c4cn(C)nc4OC)[nH]c4ncc5c(c34)n(C3CCOCC3)c(=O)n5C)ccc21			771615	US20250092044, Comparative Example B	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771615&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			162432541	523184285							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094797	[2H]C([2H])([2H])n1ncc2cc(-c3c(-c4cn(C)nc4OC)[nH]c4ncc5c(c34)n(C3CCOCC3)c(=O)n5C)ccc21			771615	US20250092044, Comparative Example B	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771615&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			162432541	523184285							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094798	Cn1cc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C)c2)n([C@H]2CC[C@@H](CC#N)CC2)c(=O)n4C)cn1			771616	US20250092044, Comparative Example C	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771616&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			162432605	523184286							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094799	Cn1cc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C)c2)n([C@H]2CC[C@@H](CC#N)CC2)c(=O)n4C)cn1			771616	US20250092044, Comparative Example C	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		 55							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771616&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			162432605	523184286							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094800	Cn1cc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C)c2)n([C@H]2CC[C@@H](CC#N)CC2)c(=O)n4C)cn1			771616	US20250092044, Comparative Example C	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		<25							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771616&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			162432605	523184286							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094801	Cn1cc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C)c2)n([C@H]2CC[C@@H](CC#N)CC2)c(=O)n4C)cn1			771616	US20250092044, Comparative Example C	High affinity nerve growth factor receptor	Homo sapiens		<25							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771616&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			162432605	523184286							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094802	COc1ccc(-c2c(-c3cnn(Cc4ccncc4)c3)[nH]c3ncc4c(c23)n(C2CCCC2)c(=O)n4C)cc1			771617	US20250092044, Comparative Example D	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771617&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			162432430	523184287							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094803	COc1ccc(-c2c(-c3cnn(Cc4ccncc4)c3)[nH]c3ncc4c(c23)n(C2CCCC2)c(=O)n4C)cc1			771617	US20250092044, Comparative Example D	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		 300							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771617&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			162432430	523184287							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094804	COc1nn(C)cc1c3[nH]c2ncc7c(c2c3c5ccc4c(cnn4C)c5)n([C@H]6CC[C@@H](CC#N)CC6)c(=O)n7C			771618	US20250092044, Comparative Example E	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771618&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			162432542	523184288							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094805	COc1nn(C)cc1c3[nH]c2ncc7c(c2c3c5ccc4c(cnn4C)c5)n([C@H]6CC[C@@H](CC#N)CC6)c(=O)n7C			771618	US20250092044, Comparative Example E	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771618&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			162432542	523184288							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094806	COc1nn(C)cc1c3[nH]c2ncc7c(c2c3c5ccc4c(cnn4C)c5)n([C@H]6CC[C@@H](CC#N)CC6)c(=O)n7C			771618	US20250092044, Comparative Example E	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771618&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			162432542	523184288							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094807	COc1nn(C)cc1c3[nH]c2ncc7c(c2c3c5ccc4c(cnn4C)c5)n([C@H]6CC[C@@H](CC#N)CC6)c(=O)n7C			771618	US20250092044, Comparative Example E	High affinity nerve growth factor receptor	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771618&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			162432542	523184288							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094808	CN(C)C(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C)c2)n(C2CCCC2)c(=O)n4C)cc1			771619	US20250092044, Comparative Example F	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771619&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			162432562	523184289							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094809	CN(C)C(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C)c2)n(C2CCCC2)c(=O)n4C)cc1			771619	US20250092044, Comparative Example F	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771619&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			162432562	523184289							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094810	CN(C)C(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C)c2)n(C2CCCC2)c(=O)n4C)cc1			771619	US20250092044, Comparative Example F	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 137.5							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771619&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			162432562	523184289							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094811	CN(C)C(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C)c2)n(C2CCCC2)c(=O)n4C)cc1			771619	US20250092044, Comparative Example F	High affinity nerve growth factor receptor	Homo sapiens		 137.5							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771619&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			162432562	523184289							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094812	CCn1c(=O)n(C2CCCC2)c2c3cc(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c3ncc21			771620	US20250092044, Comparative Example G	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771620&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			162432491	523184290							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094813	CCn1c(=O)n(C2CCCC2)c2c3cc(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c3ncc21			771620	US20250092044, Comparative Example G	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		 300							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771620&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			162432491	523184290							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094814	Cn1c(=O)n(C2CCCC2)c2c3c(-c4ccccc4)c(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c3ncc21			771621	US20250092044, Comparative Example H	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771621&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			162432544	523184291							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094815	Cn1c(=O)n(C2CCCC2)c2c3c(-c4ccccc4)c(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c3ncc21			771621	US20250092044, Comparative Example H	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		 300							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771621&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			162432544	523184291							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094816	Cn1c(=O)n(C2CCCC2)c2c3c(-c4ccccc4)c(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c3ncc21			771621	US20250092044, Comparative Example H	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 137.5							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771621&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			162432544	523184291							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094817	Cn1c(=O)n(C2CCCC2)c2c3c(-c4ccccc4)c(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c3ncc21			771621	US20250092044, Comparative Example H	High affinity nerve growth factor receptor	Homo sapiens		 137.5							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771621&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			162432544	523184291							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094818	Cn1ncc2cc(-c3c(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c4ncc5c(c34)n(C3CCCC3)c(=O)n5C)ccc21			771622	US20250092044, Comparative Example I	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771622&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			162432580	523184292							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094819	Cn1ncc2cc(-c3c(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c4ncc5c(c34)n(C3CCCC3)c(=O)n5C)ccc21			771622	US20250092044, Comparative Example I	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		 300							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771622&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			162432580	523184292							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094820	Cn1ncc2cc(-c3c(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c4ncc5c(c34)n(C3CCCC3)c(=O)n5C)ccc21			771622	US20250092044, Comparative Example I	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		<25							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771622&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			162432580	523184292							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094821	Cn1ncc2cc(-c3c(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c4ncc5c(c34)n(C3CCCC3)c(=O)n5C)ccc21			771622	US20250092044, Comparative Example I	High affinity nerve growth factor receptor	Homo sapiens		<25							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771622&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			162432580	523184292							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094822	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2cccc(F)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771623	US20250092044, Example 1	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771623&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248199	523184293							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094823	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2cccc(F)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771623	US20250092044, Example 1	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771623&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248199	523184293							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094824	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC(C)C)c(F)c5)c(-c5cccc(F)c5)c4c32)C1			771624	US20250092044, Example 2	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771624&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248174	523184294							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094825	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC(C)C)c(F)c5)c(-c5cccc(F)c5)c4c32)C1			771624	US20250092044, Example 2	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771624&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248174	523184294							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094826	CNC(=O)c1c(F)cc(-c2[nH]c3ncc4c(c3c2-c2cccc(F)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771625	US20250092044, Example 3	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771625&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248179	523184295							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094827	CNC(=O)c1c(F)cc(-c2[nH]c3ncc4c(c3c2-c2cccc(F)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771625	US20250092044, Example 3	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771625&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248179	523184295							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094828	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5cc(F)c(C(=O)NC6CC6)c(F)c5)c(-c5cccc(F)c5)c4c32)C1			771626	US20250092044, Example 4	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771626&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248190	523184296							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094829	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5cc(F)c(C(=O)NC6CC6)c(F)c5)c(-c5cccc(F)c5)c4c32)C1			771626	US20250092044, Example 4	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771626&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248190	523184296							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094830	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6C7CCC6COC7)c(OC)c5)c(-c5cccc(F)c5)c4c32)C1			771627	US20250092044, Example 5	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771627&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248236	523184297							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094831	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6C7CCC6COC7)c(OC)c5)c(-c5cccc(F)c5)c4c32)C1			771627	US20250092044, Example 5	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771627&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248236	523184297							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094832	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6C7CCC6COC7)c(OC)c5)c(-c5cccc(F)c5)c4c32)C1			771627	US20250092044, Example 5	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771627&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248236	523184297							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094833	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6C7CCC6COC7)c(OC)c5)c(-c5cccc(F)c5)c4c32)C1			771627	US20250092044, Example 5	High affinity nerve growth factor receptor	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771627&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248236	523184297							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094834	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771628	US20250092044, Example 6	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771628&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248186	523184298							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094835	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771628	US20250092044, Example 6	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771628&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248186	523184298							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094836	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771628	US20250092044, Example 6	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771628&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248186	523184298							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094837	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771628	US20250092044, Example 6	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771628&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248186	523184298							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094838	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NCCCNc6ccccc6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771629	US20250092044, Example 7	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771629&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248149	523184299							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094839	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NCCCNc6ccccc6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771629	US20250092044, Example 7	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771629&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248149	523184299							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094840	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NCCCNc6ccccc6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771629	US20250092044, Example 7	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771629&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248149	523184299							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094841	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NCCCNc6ccccc6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771629	US20250092044, Example 7	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771629&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248149	523184299							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094842	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771630	US20250092044, Example 8	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771630&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248192	523184300							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094843	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771630	US20250092044, Example 8	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771630&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248192	523184300							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094844	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771630	US20250092044, Example 8	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771630&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248192	523184300							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094845	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771630	US20250092044, Example 8	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771630&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248192	523184300							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094846	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771631	US20250092044, Example 9	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771631&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248205	523184301							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094847	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771631	US20250092044, Example 9	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771631&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248205	523184301							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094848	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771631	US20250092044, Example 9	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771631&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248205	523184301							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094849	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771631	US20250092044, Example 9	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771631&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248205	523184301							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094850	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6C(F)(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771632	US20250092044, Example 10	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771632&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248154	523184302							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094851	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6C(F)(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771632	US20250092044, Example 10	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771632&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248154	523184302							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094852	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6C(F)(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771632	US20250092044, Example 10	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771632&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248154	523184302							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094853	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6CC6C(F)(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771632	US20250092044, Example 10	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771632&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248154	523184302							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094854	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NCC(F)(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771633	US20250092044, Example 11	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771633&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248189	523184303							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094855	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NCC(F)(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771633	US20250092044, Example 11	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771633&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248189	523184303							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094856	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NCC(F)(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771633	US20250092044, Example 11	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771633&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248189	523184303							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094857	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NCC(F)(F)F)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771633	US20250092044, Example 11	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771633&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248189	523184303							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094858	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771634	US20250092044, Example 12	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771634&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248221	523184304							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094859	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771634	US20250092044, Example 12	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771634&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248221	523184304							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094860	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771634	US20250092044, Example 12	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771634&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248221	523184304							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094861	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771634	US20250092044, Example 12	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771634&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248221	523184304							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094862	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6(C(F)(F)F)CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771635	US20250092044, Example 13	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771635&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248196	523184305							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094863	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6(C(F)(F)F)CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771635	US20250092044, Example 13	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771635&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248196	523184305							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094864	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6(C(F)(F)F)CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771635	US20250092044, Example 13	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771635&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248196	523184305							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094865	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)NC6(C(F)(F)F)CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771635	US20250092044, Example 13	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771635&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248196	523184305							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094866	COCCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771636	US20250092044, Example 14	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771636&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248183	523184306							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094867	COCCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771636	US20250092044, Example 14	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771636&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248183	523184306							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094868	COCCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771636	US20250092044, Example 14	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771636&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248183	523184306							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094869	COCCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771636	US20250092044, Example 14	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771636&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248183	523184306							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094870	COCCN(C)C(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771637	US20250092044, Example 15	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771637&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248162	523184307							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094871	COCCN(C)C(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771637	US20250092044, Example 15	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771637&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248162	523184307							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094872	COCCN(C)C(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771637	US20250092044, Example 15	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771637&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248162	523184307							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094873	COCCN(C)C(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1F			771637	US20250092044, Example 15	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771637&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248162	523184307							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094874	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCOCC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771638	US20250092044, Example 16	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771638&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248173	523184308							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094875	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCOCC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771638	US20250092044, Example 16	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771638&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248173	523184308							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094876	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCOCC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771638	US20250092044, Example 16	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771638&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248173	523184308							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094877	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCOCC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771638	US20250092044, Example 16	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771638&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248173	523184308							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094878	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CC(OC)C6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771639	US20250092044, Example 17	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771639&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248218	523184309							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094879	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CC(OC)C6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771639	US20250092044, Example 17	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771639&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248218	523184309							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094880	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1OC			771640	US20250092044, Example 18	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771640&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248156	523184310							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094881	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1OC			771640	US20250092044, Example 18	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771640&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248156	523184310							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094882	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1OC			771640	US20250092044, Example 18	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771640&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248156	523184310							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094883	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1OC			771640	US20250092044, Example 18	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771640&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248156	523184310							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094884	COCCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771641	US20250092044, Example 19	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771641&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248163	523184311							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094885	COCCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771641	US20250092044, Example 19	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771641&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248163	523184311							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094886	COCCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771641	US20250092044, Example 19	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771641&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248163	523184311							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094887	COCCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771641	US20250092044, Example 19	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771641&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248163	523184311							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094888	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCOCC6)cc5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771642	US20250092044, Example 20	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771642&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248211	523184312							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094889	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCOCC6)cc5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771642	US20250092044, Example 20	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771642&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248211	523184312							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094890	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCOCC6)cc5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771642	US20250092044, Example 20	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771642&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248211	523184312							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094891	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCOCC6)cc5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771642	US20250092044, Example 20	High affinity nerve growth factor receptor	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771642&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248211	523184312							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094892	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771643	US20250092044, Example 21	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771643&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248191	523184313							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094893	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771643	US20250092044, Example 21	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771643&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248191	523184313							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094894	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771643	US20250092044, Example 21	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771643&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248191	523184313							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094895	CNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771643	US20250092044, Example 21	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771643&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248191	523184313							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094896	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N(C)C)cc5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771644	US20250092044, Example 22	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771644&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248180	523184314							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094897	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N(C)C)cc5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771644	US20250092044, Example 22	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771644&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248180	523184314							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094898	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N(C)C)cc5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771644	US20250092044, Example 22	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771644&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248180	523184314							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094899	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N(C)C)cc5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771644	US20250092044, Example 22	High affinity nerve growth factor receptor	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771644&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248180	523184314							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094900	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771645	US20250092044, Example 23	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771645&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248188	523184315							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094901	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771645	US20250092044, Example 23	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771645&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248188	523184315							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094902	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771645	US20250092044, Example 23	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771645&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248188	523184315							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094903	CCNC(=O)c1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C(C)C)c2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C)cc1			771645	US20250092044, Example 23	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771645&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248188	523184315							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094904	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCC(F)(F)CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771646	US20250092044, Example 24	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771646&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248185	523184316							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094905	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCC(F)(F)CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771646	US20250092044, Example 24	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771646&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248185	523184316							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094906	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCC(F)(F)CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771646	US20250092044, Example 24	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771646&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248185	523184316							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094907	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(C(=O)N6CCC(F)(F)CC6)c(F)c5)c(-c5ccc6c(cnn6C(C)C)c5)c4c32)C1			771646	US20250092044, Example 24	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771646&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248185	523184316							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094908	[2H]C([2H])([2H])N(Cc7ccc(c2[nH]c1ncc6c(c1c2c4ccc3OC(C)(C)Cc3c4)n([C@@H]5CC[C@@H](NC(=O)OC)C5)c(=O)n6C([2H])([2H])[2H])cc7)C([2H])([2H])[2H]			771647	US20250092044, Example 25	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771647&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248160	523184317							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094909	[2H]C([2H])([2H])N(Cc7ccc(c2[nH]c1ncc6c(c1c2c4ccc3OC(C)(C)Cc3c4)n([C@@H]5CC[C@@H](NC(=O)OC)C5)c(=O)n6C([2H])([2H])[2H])cc7)C([2H])([2H])[2H]			771647	US20250092044, Example 25	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771647&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248160	523184317							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094910	[2H]C([2H])([2H])N(Cc7ccc(c2[nH]c1ncc6c(c1c2c4ccc3OC(C)(C)Cc3c4)n([C@@H]5CC[C@@H](NC(=O)OC)C5)c(=O)n6C([2H])([2H])[2H])cc7)C([2H])([2H])[2H]			771647	US20250092044, Example 25	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771647&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248160	523184317							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094911	[2H]C([2H])([2H])N(Cc7ccc(c2[nH]c1ncc6c(c1c2c4ccc3OC(C)(C)Cc3c4)n([C@@H]5CC[C@@H](NC(=O)OC)C5)c(=O)n6C([2H])([2H])[2H])cc7)C([2H])([2H])[2H]			771647	US20250092044, Example 25	High affinity nerve growth factor receptor	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771647&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248160	523184317							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094912	[2H]C([2H])([2H])n1c(=O)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c2c3c(-c4ccc5c(cnn5C(C)C)c4)c(-c4ccc(CN(C)C)cc4)[nH]c3ncc21			771648	Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl)phenyl)-8-(1- isopropyl-1H- indazol-5-yl)-3- (methyl-d3)-2-oxo- 3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 26	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771648&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248182	523184318							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094913	[2H]C([2H])([2H])n1c(=O)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c2c3c(-c4ccc5c(cnn5C(C)C)c4)c(-c4ccc(CN(C)C)cc4)[nH]c3ncc21			771648	Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl)phenyl)-8-(1- isopropyl-1H- indazol-5-yl)-3- (methyl-d3)-2-oxo- 3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 26	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771648&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248182	523184318							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094914	[2H]C([2H])([2H])n1c(=O)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c2c3c(-c4ccc5c(cnn5C(C)C)c4)c(-c4ccc(CN(C)C)cc4)[nH]c3ncc21			771648	Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl)phenyl)-8-(1- isopropyl-1H- indazol-5-yl)-3- (methyl-d3)-2-oxo- 3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 26	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771648&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248182	523184318							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094915	[2H]C([2H])([2H])n1c(=O)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c2c3c(-c4ccc5c(cnn5C(C)C)c4)c(-c4ccc(CN(C)C)cc4)[nH]c3ncc21			771648	Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl)phenyl)-8-(1- isopropyl-1H- indazol-5-yl)-3- (methyl-d3)-2-oxo- 3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 26	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771648&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248182	523184318							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094916	[2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc(OCCOC)cc2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]			771649	Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(4-(2- methoxyethoxy)phe- nyl)-3-(methyl-d3)- 2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 27	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771649&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248208	523184319							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094917	[2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc(OCCOC)cc2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]			771649	Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(4-(2- methoxyethoxy)phe- nyl)-3-(methyl-d3)- 2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 27	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771649&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248208	523184319							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094918	[2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc(OCCOC)cc2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]			771649	Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(4-(2- methoxyethoxy)phe- nyl)-3-(methyl-d3)- 2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 27	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771649&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248208	523184319							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094919	[2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc(OCCOC)cc2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]			771649	Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(4-(2- methoxyethoxy)phe- nyl)-3-(methyl-d3)- 2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 27	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771649&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248208	523184319							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094920	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(CN(C)C)cc5)c(-c5ccc(F)cc5)c4c32)C1			771650	Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl)phenyl)-8-(4- fluorophenyl)-3- methyl-2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 28	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771650&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248217	523184320							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094921	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(CN(C)C)cc5)c(-c5ccc(F)cc5)c4c32)C1			771650	Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl)phenyl)-8-(4- fluorophenyl)-3- methyl-2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 28	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771650&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248217	523184320							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094922	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(CN(C)C)cc5)c(-c5ccc(F)cc5)c4c32)C1			771650	Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl)phenyl)-8-(4- fluorophenyl)-3- methyl-2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 28	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771650&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248217	523184320							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094923	COC(=O)N[C@@H]1CC[C@@H](n2c(=O)n(C)c3cnc4[nH]c(-c5ccc(CN(C)C)cc5)c(-c5ccc(F)cc5)c4c32)C1			771650	Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl)phenyl)-8-(4- fluorophenyl)-3- methyl-2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 28	High affinity nerve growth factor receptor	Homo sapiens		>2500							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771650&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248217	523184320							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094924	[2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(c2)COC3(C)C)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]			771651	Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(1,1- dimethyl-1,3- dihydroisobenzofuran- 5-yl)-3-(methyl- d3)-2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 29	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771651&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248227	523184321							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094925	[2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(c2)COC3(C)C)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]			771651	Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(1,1- dimethyl-1,3- dihydroisobenzofuran- 5-yl)-3-(methyl- d3)-2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 29	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771651&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248227	523184321							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094926	[2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(c2)COC3(C)C)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]			771651	Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(1,1- dimethyl-1,3- dihydroisobenzofuran- 5-yl)-3-(methyl- d3)-2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 29	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771651&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248227	523184321							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094927	[2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(c2)COC3(C)C)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]			771651	Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(1,1- dimethyl-1,3- dihydroisobenzofuran- 5-yl)-3-(methyl- d3)-2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 29	High affinity nerve growth factor receptor	Homo sapiens		 1875							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771651&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248227	523184321							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094928	[2H]C([2H])([2H])n1c(=O)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c2c3c(-c4ccc5c(c4)COC5(C)C)c(-c4ccc(C(=O)N(C)C)cc4)[nH]c3ncc21			771652	US20250092044, Example 30	Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]	Homo sapiens		<10							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1446&target=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771652&enzyme=Tyrosine-protein+kinase+JAK2+%5B536-812%2CV617F%2CW659A%2CW777A%2CF794H%5D&column=ki&startPg=0&Increment=50&submit=Search			176248299	523184322							1	VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD	8BAK,8BAB,8B9E,8B99,4FVR,7F7W,6D2I,9ND5	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094929	[2H]C([2H])([2H])n1c(=O)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c2c3c(-c4ccc5c(c4)COC5(C)C)c(-c4ccc(C(=O)N(C)C)cc4)[nH]c3ncc21			771652	US20250092044, Example 30	Tyrosine-protein kinase JAK2 [826-1132]	Homo sapiens		>1000							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=926&target=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771652&enzyme=Tyrosine-protein+kinase+JAK2+%5B826-1132%5D&column=ki&startPg=0&Increment=50&submit=Search			176248299	523184322							1	RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG	4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,5AEP,4D1S,4D0X,4D0W,4AQC,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,7LL5,3LPB,3KRR,3E64,3E63,3E62,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,4P7E,3FUP,2B7A,7UYW,4YTI,4YTH,4YTF,4YTC,3KCK,3IOK,3IO7,3JY9	Tyrosine-protein kinase JAK2	JAK2_HUMAN	O60674	O14636 O75297																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094930	[2H]C([2H])([2H])n1c(=O)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c2c3c(-c4ccc5c(c4)COC5(C)C)c(-c4ccc(C(=O)N(C)C)cc4)[nH]c3ncc21			771652	US20250092044, Example 30	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1358&target=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771652&enzyme=Receptor-type+tyrosine-protein+kinase+FLT3&column=ki&startPg=0&Increment=50&submit=Search			176248299	523184322							1	MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS	3QS9,3QS7,4RT7,1RJB,5X02,6JQR,4XUF	Receptor-type tyrosine-protein kinase FLT3	FLT3_HUMAN	P36888	A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1094931	[2H]C([2H])([2H])n1c(=O)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c2c3c(-c4ccc5c(c4)COC5(C)C)c(-c4ccc(C(=O)N(C)C)cc4)[nH]c3ncc21			771652	US20250092044, Example 30	High affinity nerve growth factor receptor	Homo sapiens		 750							US Patent		10.7270/Q20006V9			US20250092044	Zheng, Z; Ai, Y; Burns, DM; Liu, K; Taylor, CA; Yue, EW	3/20/2025	12/31/2025	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771652&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			176248299	523184322							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7