BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1094932 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4CC4(CC#N)CC4)c(F)c3)c2O1 771653 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- ((1- (cyanomethyl)cyclo- propyl)methyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 1 Glucagon-like peptide 1 receptor Homo sapiens 0.510 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771653 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771653&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813734 523184323 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094933 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)c(F)c5n4C[C@@H]4CCO4)c(F)c3)c2O1 771654 2-(4-(2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)-2,6-difluorobenzyl)-7-fluoro-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid (Example 2)::US20250099431, Example 2 Glucagon-like peptide 1 receptor Homo sapiens 0.170 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771654 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771654&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813658 523184324 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094934 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(C(=O)NS(=O)(=O)C3CC3)cc21 771655 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-N- (cyclopropylsulfonyl)- 1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxamide::US20250099431, Example 3 Glucagon-like peptide 1 receptor Homo sapiens 78.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771655 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771655&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813753 523184325 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094935 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771656 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo[d][1, 3]dioxol-4- yl)-2- fluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 4 Glucagon-like peptide 1 receptor Homo sapiens 103 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771656 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771656&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813663 523184326 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094936 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771657 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo[d][1, 3]dioxol-4- yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 5 Glucagon-like peptide 1 receptor Homo sapiens 161 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771657 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771657&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813657 523184327 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094937 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccc(C#N)cc3)O4)cc2F)nc2ccc(C(=O)O)cc21 771658 2-(4-(2-(4- cyanophenyl)benzo[d][1, 3]dioxol-4-yl)-2- fluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 6 Glucagon-like peptide 1 receptor Homo sapiens 219 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771658 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771658&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149710 523184328 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094938 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccccc3)C4)cc2F)nc2ccc(C(=O)O)cc21 771659 2-(2-fluoro-4-(2- phenyl-2,3- dihydrobenzofuran- 7-yl)benzyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 7 Glucagon-like peptide 1 receptor Homo sapiens 530 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771659 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771659&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813670 523184329 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094939 COCCn1c(Cc2ccc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)s2)nc2ccc(C(=O)O)cc21 771660 2-((5-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4- yl)thiophen-2- yl)methyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 8 Glucagon-like peptide 1 receptor Homo sapiens 78.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771660 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771660&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813648 523184330 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094940 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5c(F)cc(C(=O)O)cc5n4CC4(CC(N)=O)CC4)c(F)c3)c2O1 771661 1-((1-(2-amino-2- oxoethyl)cyclopro- pyl)methyl)-2-(4- (2-(4-chloro-2- fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-4- fluoro-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 9 Glucagon-like peptide 1 receptor Homo sapiens 8.60 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771661 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771661&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813720 523184331 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094941 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(CCC(=O)O)(c3ccc(Cl)cc3)N4)cc2F)nc2ccc(C(=O)O)cc21 771662 2-(4-(2-(2- carboxyethyl)-2- (4-chlorophenyl)- 2,3- dihydrobenzo[d]oxazol- 7-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 10 Glucagon-like peptide 1 receptor Homo sapiens 130 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771662 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771662&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813772 523184332 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094942 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C#N)s3)O4)cc2F)nc2ccc(C(=O)O)cc21 771663 2-(4-(2-(5- cyanothiophen-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 11 Glucagon-like peptide 1 receptor Homo sapiens 34.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771663 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771663&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813674 523184333 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094943 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4CC4(CF)CC4)c(F)c3)c2O1 771664 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- ((1- (fluoromethyl)cyclo- propyl)methyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 12 Glucagon-like peptide 1 receptor Homo sapiens 2.40 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771664 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771664&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813727 523184334 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094944 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5c(F)cc(C(=O)O)cc5n4CC4(CC#N)CC4)c(F)c3)c2O1 771665 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- ((1- (cyanomethyl)cyclo- propyl)methyl)- 4-fluoro-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 13 Glucagon-like peptide 1 receptor Homo sapiens 0.410 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771665 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771665&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813739 523184335 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094945 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cnc(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771666 2-((5-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-3- fluoropyridin-2- yl)methyl)-1-(((S)- oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 14 Glucagon-like peptide 1 receptor Homo sapiens 4.50 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771666 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771666&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149680 523184336 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094946 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3ccc(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)cc3F)c2O1 771667 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-3- fluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 15 Glucagon-like peptide 1 receptor Homo sapiens 0.015 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771667 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771667&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813669 523184337 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094947 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC3(c5ccc(Cl)cc5)CCCN43)cc2F)nc2ccc(C(=O)O)cc21 771668 2-(4-(3a-(4- chlorophenyl)- 1,2,3,3a- tetrahydrobenzo[d] pyrrolo[2,1- b]oxazol-5-yl)- 2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 16 Glucagon-like peptide 1 receptor Homo sapiens 6916 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771668 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771668&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813765 523184338 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094948 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC3(c5ccc(Cl)cc5)CCC(=O)N43)cc2F)nc2ccc(C(=O)O)cc21 771669 2-(4-(3a-(4- chlorophenyl)-1- oxo-1,2,3,3a- tetrahydrobenzo[d] pyrrolo[2,1- b]oxazol-5-yl)- 2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 17 Glucagon-like peptide 1 receptor Homo sapiens 10000 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771669 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771669&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813712 523184339 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094949 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(C#N)c3)c2O1 771670 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- cyano-6- fluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 18 Glucagon-like peptide 1 receptor Homo sapiens 0.140 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771670 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771670&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149689 523184340 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094950 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771671 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 19 Glucagon-like peptide 1 receptor Homo sapiens 0.970 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771671 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771671&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813643 523184341 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094951 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3F)c2O1 771672 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)- 2,3,6- trifluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 20 Glucagon-like peptide 1 receptor Homo sapiens 0.089 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771672 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771672&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813707 523184342 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094952 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)nc5n4CC4(CF)CC4)c(F)c3)c2O1 771673 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-3- ((1- (fluoromethyl)cyclo- propyl)methyl)- 3H-imidazo[4,5- b]pyridine-5- carboxylic acid::US20250099431, Example 21 Glucagon-like peptide 1 receptor Homo sapiens 0.860 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771673 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771673&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813639 523184343 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094953 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771674 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 22 Glucagon-like peptide 1 receptor Homo sapiens 0.024 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771674&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813705 523184344 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094954 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3ccc(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771675 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- fluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 23 Glucagon-like peptide 1 receptor Homo sapiens 0.490 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771675 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771675&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813708 523184345 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094955 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4CC4(CC#N)CC4)c(F)c3)c2O1 771676 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- ((1- (cyanomethyl)cyclo- propyl)methyl)- 1H- benzo[d]imidazole 6-carboxylic acid::US20250099431, Example 24 Glucagon-like peptide 1 receptor Homo sapiens 1.70 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771676 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771676&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813673 523184346 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094956 COC(=O)c1ccc2nc(Cc3cc(F)c(-c4cccc5c4OC(C)(c4ccc(C#N)cc4F)O5)cc3F)n(C[C@@H]3CCO3)c2c1 771677 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 25 Glucagon-like peptide 1 receptor Homo sapiens 0.300 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771677 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771677&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149684 523184347 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094957 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3ccn(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(=O)c3)c2O1 771678 2-((4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- oxopyridin-1(2H)- yl)methyl)-1-(((S)- oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 26 Glucagon-like peptide 1 receptor Homo sapiens 37.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771678 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771678&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149685 523184348 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094958 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771679 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 27 Glucagon-like peptide 1 receptor Homo sapiens 0.530 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771679 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771679&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813622 523184349 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094959 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)cc3F)c2O1 771680 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 28 Glucagon-like peptide 1 receptor Homo sapiens 0.034 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771680 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771680&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813722 523184350 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094960 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)cc3F)c2O1 771681 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 29 Glucagon-like peptide 1 receptor Homo sapiens 0.076 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771681 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771681&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813778 523184351 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094961 N#Cc1ccc(C2Oc3cccc(-c4cc(F)c(Cc5nc6ccc(C(=O)O)cc6n5C[C@@H]5CCO5)c(F)c4)c3O2)c(F)c1 771682 (S)-2-(4-(2-(4- cyano-2- fluorophenyl)benzo [d][1,3]dioxol-4- yl)-2,6- difluorobenzyl)-1- (oxetan-2- ylmethyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 30 Glucagon-like peptide 1 receptor Homo sapiens 1.90 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771682 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771682&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813694 523184352 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094962 COCCn1c(Cc2cc(F)c(-c3cccc4c3OC(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771683 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo [d][1,3]dioxol-4- yl)-2,5- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 31 Glucagon-like peptide 1 receptor Homo sapiens 89.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771683 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771683&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813645 523184353 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094963 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccccc3)O4)cc2F)nc2ccc(C(=O)O)cc21 771684 2-(2-fluoro-4-(2- phenylbenzo[d][1, 3]dioxol-4- yl)benzyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 32 Glucagon-like peptide 1 receptor Homo sapiens 1919 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771684 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771684&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813678 523184354 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094964 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771685 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo [d][1,3]dioxol-4- yl)-2- fluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 33 Glucagon-like peptide 1 receptor Homo sapiens 53.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771685 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771685&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813663 523184355 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094965 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771686 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo [d][1,3]dioxol-4- fluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 34 Glucagon-like peptide 1 receptor Homo sapiens 350 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771686 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771686&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813663 523184356 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094966 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccccc3)O4)cc2F)nc2ccc(C(=O)O)cc21 771687 2-(2-fluoro-4-(2- phenylbenzo[d][1, 3]dioxol-4- yl)benzyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 35 Glucagon-like peptide 1 receptor Homo sapiens 646 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771687 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771687&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813678 523184357 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094967 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccccc3)O4)cc2F)nc2ccc(C(=O)O)cc21 771688 2-(2-fluoro-4-(2- phenylbenzo[d][1, 3]dioxol-4- yl)benzyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 36 Glucagon-like peptide 1 receptor Homo sapiens 242 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771688 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771688&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813678 523184358 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094968 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771689 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo [d][1,3]dioxol-4- yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 37 Glucagon-like peptide 1 receptor Homo sapiens 1000 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771689 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771689&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813657 523184359 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094969 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771690 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo [d][1,3]dioxol-4- yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 38 Glucagon-like peptide 1 receptor Homo sapiens 37.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771690 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771690&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813657 523184360 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094970 COCCn1c(Cc2cc(F)c(-c3cccc4c3OC(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771691 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo [d][1,3]dioxol-4- yl)-2,5- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 39 Glucagon-like peptide 1 receptor Homo sapiens 49.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771691 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771691&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813645 523184361 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094971 COCCn1c(Cc2cc(F)c(-c3cccc4c3OC(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771692 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo [d][1,3]dioxol-4- yl)-2,5- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 40 Glucagon-like peptide 1 receptor Homo sapiens 1234 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771692 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771692&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813645 523184362 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094972 N#Cc1ccc(C2Oc3cccc(-c4cc(F)c(Cc5nc6ccc(C(=O)O)cc6n5C[C@@H]5CCO5)c(F)c4)c3O2)c(F)c1 771693 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo [d][1,3]dioxol-4- yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 41 Glucagon-like peptide 1 receptor Homo sapiens 438 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771693 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771693&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813694 523184363 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094973 N#Cc1ccc(C2Oc3cccc(-c4cc(F)c(Cc5nc6ccc(C(=O)O)cc6n5C[C@@H]5CCO5)c(F)c4)c3O2)c(F)c1 771694 2-(4-(2-(4-cyano- 2- fluorophenyl)benzo [d][1,3]dioxol-4- yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 42 Glucagon-like peptide 1 receptor Homo sapiens 1.10 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771694 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771694&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813694 523184364 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094974 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)cc3F)c2O1 771695 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 43 Glucagon-like peptide 1 receptor Homo sapiens 7.40 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771695 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771695&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813722 523184365 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094975 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)cc3F)c2O1 771696 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 44 Glucagon-like peptide 1 receptor Homo sapiens 0.033 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771696 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771696&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813722 523184366 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094976 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)cc3F)c2O1 771697 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 45 Glucagon-like peptide 1 receptor Homo sapiens 0.190 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771697 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771697&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813778 523184367 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094977 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)cc3F)c2O1 771698 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 46 Glucagon-like peptide 1 receptor Homo sapiens 17.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771698 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771698&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813778 523184368 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094978 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771699 2-(4-(2(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 47 Glucagon-like peptide 1 receptor Homo sapiens 0.070 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771699 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771699&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813705 523184369 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094979 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771700 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 48 Glucagon-like peptide 1 receptor Homo sapiens 1.20 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771700 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771700&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813705 523184370 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094980 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771701 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 49 Glucagon-like peptide 1 receptor Homo sapiens 0.310 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771701 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771701&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813622 523184371 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094981 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771702 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 50 Glucagon-like peptide 1 receptor Homo sapiens 16.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771702 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771702&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813622 523184372 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094982 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3ccc(Cc4nc5ccc(C(=O)O)cc5n4CC4(n5ccnn5)CC4)c(F)c3)c2O1 771703 1-((1-(1H-1,2,3- triazol-1- yl)cyclopropyl) methyl)-2-(4-(2-(4- chloro-2- fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- fluorobenzyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 51 Glucagon-like peptide 1 receptor Homo sapiens 9.10 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771703 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771703&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813675 523184373 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094983 COCCn1c(Cc2ccc(-c3cccc4c3OC(C)(c3nc5ccccc5n3C)O4)cc2F)nc2ccc(C(=O)O)cc21 771704 2-[[2-fluoro-4-[2- methyl-2-(1- methylbenzimidazol- 2-yl)-1,3- benzodioxol-4- yl]phenyl]methyl]- 3-(2- methoxyethyl) benzimidazole-5- carboxylic acid::US20250099431, Example 52 Glucagon-like peptide 1 receptor Homo sapiens 2269 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771704 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771704&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813725 523184374 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094984 CCC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4CCOC)c(F)c3)c2O1 771705 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- ethylbenzo[d][1,3] dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 53 Glucagon-like peptide 1 receptor Homo sapiens 1288 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771705 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771705&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149687 523184375 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094985 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC3c5ccc(Cl)cc5OC43)cc2F)nc2ccc(C(=O)O)cc21 771706 2-(4-(7-chloro- 4b,9b- dihydrobenzofuro [3,2-b]benzofuran- 1-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 54 Glucagon-like peptide 1 receptor Homo sapiens 628 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771706 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771706&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813730 523184376 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094986 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC3(CCCOc5cc(Cl)ccc53)O4)cc2F)nc2ccc(C(=O)O)cc21 771707 2-(4-(8-chloro-3,4- dihydro-2H- spiro[benzo[b] oxepine-5,2'- benzo[d][1,3] dioxol]-4'-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 55 Glucagon-like peptide 1 receptor Homo sapiens 1273 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771707 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771707&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813661 523184377 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094987 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC3(CCCc5cc(Cl)ccc53)O4)cc2F)nc2ccc(C(=O)O)cc21 771708 2-(4-(6'-chloro- 3',4'-dihydro-2'H- spiro[benzo[d][1,3] dioxole-2,1'- naphthalen]-4-yl)- 2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 56 Glucagon-like peptide 1 receptor Homo sapiens 3746 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771708 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771708&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813709 523184378 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094988 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC3(CCCCc5cc(Cl)ccc53)O4)cc2F)nc2ccc(C(=O)O)cc21 771709 2-(4-(2'-chloro- 6',7',8',9'- tetrahydrospiro[benzo [d][1,3]dioxole- 2,5'- benzo[7]annulen]- 4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 57 Glucagon-like peptide 1 receptor Homo sapiens 347 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771709 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771709&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813749 523184379 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094989 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C(F)(F)F)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771710 2-(2,6-difluoro-4- (2-(2-fluoro-4- (trifluoromethyl) phenyl)-2- methylbenzo[d][1, 3]dioxol-4- yl)benzyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 58 Glucagon-like peptide 1 receptor Homo sapiens 6.30 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771710&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813637 523184380 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094990 COCCn1c(Cc2cc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)cs2)nc2ccc(C(=O)O)cc21 771711 2-((4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4- yl)thiophen-2- yl)methyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 59 Glucagon-like peptide 1 receptor Homo sapiens 1624 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771711 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771711&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813647 523184381 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094991 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3OC)O4)cc2F)nc2ccc(C(=O)O)cc21 771712 2-(4-(2-(4-chloro- 2- methoxyphenyl)- 2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 60 Glucagon-like peptide 1 receptor Homo sapiens 3.80 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771712&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813659 523184382 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094992 COCCn1c(Cc2csc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)c2)nc2ccc(C(=O)O)cc21 771713 2-((5-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4- yl)thiophen-3- yl)methyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 61 Glucagon-like peptide 1 receptor Homo sapiens 639 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771713&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813640 523184383 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094993 COCCn1c(Cc2cc(F)c(-c3cccc4c3OC(C)(c3ccc(C#N)cc3F)O4)cc2F)nc2c(F)cc(C(=O)O)cc21 771714 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-4- fluoro-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 62 Glucagon-like peptide 1 receptor Homo sapiens 2.50 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771714 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771714&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149714 523184384 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094994 CC1(c2ccc(C(F)(F)F)cc2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)cc3F)c2O1 771715 2-(2,5-difluoro-4- (2-methyl-2-(4- (trifluoromethyl) phenyl)benzo[d][1, 3]dioxol-4- yl)benzyl)-1-(((S)- oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 63 Glucagon-like peptide 1 receptor Homo sapiens 0.620 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771715 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771715&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813728 523184385 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094995 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(Cl)cn3)O4)cc2F)nc2ccc(C(=O)O)cc21 771716 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 64 Glucagon-like peptide 1 receptor Homo sapiens 111 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771716 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771716&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813664 523184386 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094996 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(Cl)cn3)O4)cc2F)nc2ccc(C(=O)O)cc21 771717 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 65 Glucagon-like peptide 1 receptor Homo sapiens 10.00 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771717&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813664 523184387 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094997 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C#N)cn3)O4)cc2F)nc2ccc(C(=O)O)cc21 771718 2-(4-(2-(5- cyanopyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 66 Glucagon-like peptide 1 receptor Homo sapiens 21.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771718 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771718&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149707 523184388 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094998 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C(N)=O)cn3)O4)cc2F)nc2ccc(C(=O)O)cc21 771719 2-(4-(2-(5- carbamoylpyridin- 2-yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 67 Glucagon-like peptide 1 receptor Homo sapiens 20.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771719 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771719&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813724 523184389 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1094999 CCn1cnnc1Cn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771720 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- ((4-ethyl-4H- 1,2,4-triazol-3- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 68 Glucagon-like peptide 1 receptor Homo sapiens 12.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771720&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813774 523184390 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1095000 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4Cc4ncco4)c(F)c3)c2O1 771721 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (oxazol-2- ylmethyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 69 Glucagon-like peptide 1 receptor Homo sapiens 2.50 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771721&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813787 523184391 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1095001 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3F)c2O1 771722 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)- 2,3,6- trifluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 70 Glucagon-like peptide 1 receptor Homo sapiens 0.780 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771722&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813630 523184392 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1095002 O=C(O)c1ccc2nc(Cc3c(F)cc(-c4cccc5c4CN(c4ccc(Cl)cc4F)C5)cc3F)n(C[C@@H]3CCO3)c2c1 771723 (S)-2-(4-(2-(4- chloro-2- fluorophenyl) isoindolin-4-yl)-2,6- difluorobenzyl)-1- (oxetan-2- ylmethyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 71 Glucagon-like peptide 1 receptor Homo sapiens 10000 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771723 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771723&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813746 523184393 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1095003 O=C(O)c1ccc2nc(Cc3c(F)cc(-c4cccc5c4C(=O)N(c4ccc(Cl)cc4F)C5)cc3F)n(C[C@@H]3CCO3)c2c1 771724 (S)-2-(4-(2-(4- chloro-2- fluorophenyl)-3- oxoisoindolin-4- yl)-2,6- difluorobenzyl)-1- (oxetan-2- ylmethyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 72 Glucagon-like peptide 1 receptor Homo sapiens 10000 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771724&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813651 523184394 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1095004 O=C(O)c1ccc2nc(Cc3c(F)cc(-c4cccc5c4CN(c4ccc(Cl)cc4F)C5=O)cc3F)n(C[C@@H]3CCO3)c2c1 771725 (S)-2-(4-(2-(4- chloro-2- fluorophenyl)-1- oxoisoindolin-4- yl)-2,6- difluorobenzyl)-1- (oxetan-2- ylmethyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 73 Glucagon-like peptide 1 receptor Homo sapiens 10000 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771725&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813758 523184395 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1095005 CC1(c2ccc(Cl)cn2)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(C#N)c3)c2O1 771726 2-(4-(2-(5- chloropyridin-2- yl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- cyano-6- fluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 74 Glucagon-like peptide 1 receptor Homo sapiens 1.70 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771726 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771726&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813723 523184396 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1095006 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)nc5n4CC4(CC#N)CC4)cc3F)c2O1 771727 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-3- ((1- (cyanomethyl) cyclopropyl)methyl)- 3H-imidazo[4,5- b]pyridine-5- carboxylic acid::US20250099431, Example 75 Glucagon-like peptide 1 receptor Homo sapiens 0.700 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771727&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813747 523184397 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096392 CC1(c2ccc(Cl)cn2)Oc2ccc(F)c(-c3ccc(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771728 2-(4-(2-(5- chloropyridin-2- yl)-5-fluoro-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- fluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 76 Glucagon-like peptide 1 receptor Homo sapiens 4.30 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771728&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813766 523184398 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096393 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3ccc(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)cn3)c2O1 771729 2-((6-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4- yl)pyridin-3- yl)methyl)-1-(((S)- oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 77 Glucagon-like peptide 1 receptor Homo sapiens 72.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771729&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813773 523184399 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096394 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccc(Cl)cn3)C4)cc2F)nc2ccc(C(=O)O)cc21 771730 2-(4-(2-(5- chloropyridin-2- yl)-2,3- dihydrobenzofuran- 7-yl)-2- fluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 78 Glucagon-like peptide 1 receptor Homo sapiens 1782 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771730&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813693 523184400 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096395 COCCn1c(Cc2ccc(-c3cccc4c3OC(c3ccc(Cl)cc3F)C4)cc2F)nc2ccc(C(=O)O)cc21 771731 2-(4-(2-(4-chloro- 2-fluorophenyl)- 2,3- dihydrobenzofuran- 7-yl)-2- fluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 79 Glucagon-like peptide 1 receptor Homo sapiens 738 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771731&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813632 523184401 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096396 COCCn1c(Cc2ccc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771732 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- fluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 80 Glucagon-like peptide 1 receptor Homo sapiens 11.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771732&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149683 523184402 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096397 COCCn1c(Cc2cc(F)c(-c3cccc4c3OC(C)(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)OC)cc21 771733 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 81 Glucagon-like peptide 1 receptor Homo sapiens 26.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771733&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149711 523184403 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096398 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(CC4Nc5ccc(C(=O)O)cc5N4CCS(C)(=O)=O)c(F)c3)c2O1 771734 2-[[4-[2-(4-chloro- 2-fluoro-phenyl)- 2-methyl-1,3- benzodioxol-4-yl]- 2,6-difluoro- phenyl]methyl]-3- (2- methylsulfonylethyl) benzimidazole- 5-carboxylic acid::US20250099431, Example 82 Glucagon-like peptide 1 receptor Homo sapiens 20.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771734&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 177858802 523184404 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096399 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4CCOC(F)F)c(F)c3)c2O1 771735 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2- (difluoromethoxy) ethyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 83 Glucagon-like peptide 1 receptor Homo sapiens 13.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771735&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813676 523184405 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096400 COCCn1c(Cc2cc(F)c(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(-c3nn[nH]n3)cc21 771736 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (2-methoxyethyl)- 6-(2H-tetrazol-5- yl)-1H- benzo[d]imidazole::US20250099431, Example 84 Glucagon-like peptide 1 receptor Homo sapiens 49.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771736&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813702 523184406 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096401 COCCn1c(Cc2ccc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)nc2OC)nc2ccc(C(=O)O)cc21 771737 2-((6-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- methoxypyridin-3- yl)methyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 85 Glucagon-like peptide 1 receptor Homo sapiens 168 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771737 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771737&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813677 523184407 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096402 COCCn1c(Cc2ccc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)[nH]c2=O)nc2ccc(C(=O)O)cc21 771738 2-((6-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- oxo-1,2- dihydropyridin-3- yl)methyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 86 Glucagon-like peptide 1 receptor Homo sapiens 13.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771738 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771738&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813652 523184408 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096403 COCCn1c(Cc2ccc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)n(C)c2=O)nc2ccc(C(=O)O)cc21 771739 2-((6-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-1- methyl-2-oxo-1,2- dihydropyridin-3- yl)methyl)-1-(2- methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 87 Glucagon-like peptide 1 receptor Homo sapiens 1152 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771739 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771739&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813665 523184409 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096404 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C#N)cc3F)O4)c(F)c2F)nc2ccc(C(=O)O)cc21 771740 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)- 2,3,6- trifluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 88 Glucagon-like peptide 1 receptor Homo sapiens 12.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771740 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771740&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813735 523184410 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096405 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771741 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 89 Glucagon-like peptide 1 receptor Homo sapiens 15.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771741 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771741&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813781 523184411 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096406 CC1(c2ccc(C#N)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3F)c2O1 771742 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)- 2,3,6- trifluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 90 Glucagon-like peptide 1 receptor Homo sapiens 0.230 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771742 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771742&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813738 523184412 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096407 CC1(c2ccc(C#N)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771743 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 91 Glucagon-like peptide 1 receptor Homo sapiens 0.690 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771743 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771743&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813756 523184413 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096408 CC1(c2ccc(C#N)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771744 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 92 Glucagon-like peptide 1 receptor Homo sapiens 3.30 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771744 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771744&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813756 523184414 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096409 CC1(c2ccc(C#N)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3)c2O1 771745 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 93 Glucagon-like peptide 1 receptor Homo sapiens 0.520 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771745 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771745&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813756 523184415 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096410 CC1(c2ccc(C#N)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3F)c2O1 771746 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)- 2,3,6- trifluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 94 Glucagon-like peptide 1 receptor Homo sapiens 0.320 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771746 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771746&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813738 523184416 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096411 CC1(c2ccc(C#N)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)c(F)c3F)c2O1 771747 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)- 2,3,6- trifluorobenzyl)-1- (((S)-oxetan-2- yl)methyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 95 Glucagon-like peptide 1 receptor Homo sapiens 21.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771747 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771747&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813738 523184417 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096412 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C#N)cc3F)O4)c(F)c2F)nc2ccc(C(=O)O)cc21 771748 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)- 2,3,6- trifluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 96 Glucagon-like peptide 1 receptor Homo sapiens 57.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771748 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771748&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813735 523184418 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096413 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C#N)cc3F)O4)c(F)c2F)nc2ccc(C(=O)O)cc21 771749 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)- 2,3,6- trifluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 97 Glucagon-like peptide 1 receptor Homo sapiens 1.90 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771749 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771749&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813735 523184419 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096414 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771750 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 98 Glucagon-like peptide 1 receptor Homo sapiens 67.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771750 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771750&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813781 523184420 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096415 COCCn1c(Cc2c(F)cc(-c3cccc4c3OC(C)(c3ccc(C#N)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771751 2-(4-(2-(4-cyano- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 99 Glucagon-like peptide 1 receptor Homo sapiens 2.40 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771751 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771751&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813781 523184421 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096416 COCCn1c(Cc2c(F)cc(-c3c(F)ccc4c3OC(C)(c3ccc(Cl)cn3)O4)cc2F)nc2ccc(C(=O)O)cc21 771752 2-(4-(2-(5- chloropyridin-2- yl)-5-fluoro-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 100 Glucagon-like peptide 1 receptor Homo sapiens 14.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771752 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771752&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813644 523184422 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096417 COCCn1c(Cc2cc(F)c(-c3c(F)ccc4c3OC(C)(c3ccc(Cl)cn3)O4)cc2F)nc2ccc(C(=O)O)cc21 771753 2-(4-(2-(5- chloropyridin-2- yl)-5-fluoro-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,5- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 101 Glucagon-like peptide 1 receptor Homo sapiens 160 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771753 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771753&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813660 523184423 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096418 COCCn1c(Cc2c(F)cc(-c3cccc4c3O[C@@](C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771754 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 102 Glucagon-like peptide 1 receptor Homo sapiens 65.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771754 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771754&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813621 523184424 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096419 COCCn1c(Cc2c(F)cc(-c3cccc4c3O[C@](C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771755 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- (2-methoxyethyl)- 1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 103 Glucagon-like peptide 1 receptor Homo sapiens 8.20 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771755 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771755&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813764 523184425 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096420 COCCn1c(CN/C=C(\N=N)c2cccc3c2OC(C)(c2ccc(Cl)cn2)O3)nc2ccc(C(=O)O)cc21 771756 2-[[4-[2-(5- Chloro-2-pyridyl)- 2-methyl-1,3- benzodioxol-4- yl]triazol-1- yl]methyl]-3-(2- methoxyethyl) bencarboxylic acid::US20250099431, Example 104 Glucagon-like peptide 1 receptor Homo sapiens 3033 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771756 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771756&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 165149706 523184426 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096421 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5c(F)cc(C(=O)O)cc5n4CC4(CC#N)CC4)c(F)c3)c2O1 771757 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- ((1- (cyanomethyl) cyclopropyl)methyl)- 4-fluoro-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 105 Glucagon-like peptide 1 receptor Homo sapiens 2.60 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771757 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771757&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813739 523184427 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096422 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5c(F)cc(C(=O)O)cc5n4CC4(CC#N)CC4)c(F)c3)c2O1 771758 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2,6- difluorobenzyl)-1- ((1- (cyanomethyl) cyclopropyl)methyl)- 4-fluoro-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 106 Glucagon-like peptide 1 receptor Homo sapiens 0.640 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771758 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771758&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813739 523184428 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096423 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3ccc(Cc4nc5ccc(C(=O)O)cc5n4Cc4ccon4)c(F)c3)c2O1 771759 2-(4-(2-(4-chloro- 2-fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- fluorobenzyl)-1- (isoxazol-3- ylmethyl)-3a,7a- dihydro-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 107 Glucagon-like peptide 1 receptor Homo sapiens 1.90 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771759 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771759&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813744 523184429 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096424 CC(=O)N1CC[C@@H]1Cn1c(Cc2ccc(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771760 3-[[(2R)-1- acetylazetidin-2- yl]methyl]-2-[[4- [2-(4-chloro-2- fluoro-phenyl)-2- methyl-1,3- benzodioxol-4-yl]- 2-fluoro- phenyl]methyl] benzimidazole-5- carboxylic acid::US20250099431, Example 108 Glucagon-like peptide 1 receptor Homo sapiens 4.30 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771760 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771760&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813655 523184430 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096425 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3ccc(Cc4nc5ccc(C(=O)O)cc5n4CC4(n5ccnn5)CC4)c(F)c3)c2O1 771761 1-((1-(1H-1,2,3- triazol-1- yl)cyclopropyl) methyl)-2-(4-(2-(4- chloro-2- fluorophenyl)-2- methylbenzo[d][1, 3]dioxol-4-yl)-2- fluorobenzyl)-1H- benzo[d]imidazole- 6-carboxylic acid::US20250099431, Example 109 Glucagon-like peptide 1 receptor Homo sapiens 9.10 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771761&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813675 523184431 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096426 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCCO4)c(F)c3)c2O1 771762 2-[[4-[2-(4-chloro- 2-fluoro-phenyl)- 2-methyl-1,3- benzodioxol-4-yl]- 2,5-difluoro- phenyl]methyl]-3- [[(2S)- tetrahydrofuran-2- yl]methyl] benzimidazole-5- carboxylic acid::US20250099431, Example 110 Glucagon-like peptide 1 receptor Homo sapiens 7.10 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771762 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771762&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813683 523184432 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096427 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCCO4)c(F)c3)c2O1 771763 2-[[4-[2-(4-chloro- 2-fluoro-phenyl)- 2-methyl-1,3- benzodioxol-4-yl]- 2,5-difluoro- phenyl]methyl]-3- [[(2S)- tetrahydrofuran-2- yl]methyl] benzimidazole-5- carboxylic acid::US20250099431, Example 111 Glucagon-like peptide 1 receptor Homo sapiens 377 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771763&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813683 523184433 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096428 CC1(c2ccc(Cl)cc2F)Oc2cccc(-c3cc(F)c(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCCO4)c(F)c3)c2O1 771764 2-[[4-[2-(4-chloro- 2-fluoro-phenyl)- 2-methyl-1,3- benzodioxol-4-yl]- 2,5-difluoro- phenyl]methyl]-3- [[(2S)- tetrahydrofuran-2- yl]methyl] benzimidazole-5- carboxylic acid::US20250099431, Example 112 Glucagon-like peptide 1 receptor Homo sapiens 3.30 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771764&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813683 523184434 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096429 COCCn1c(Cc2cc(F)c(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771765 2-[[4-[2-(4-chloro- 2-fluoro-phenyl)- 2-methyl-1,3- benzodioxol-4-yl]- 2,5-difluoro- phenyl]methyl]-3- (2- methoxyethyl) benzimidazole-5- carboxylic acid::US20250099431, Example 113 Glucagon-like peptide 1 receptor Homo sapiens 2.80 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771765 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771765&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813687 523184435 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669 1096430 COCCn1c(Cc2cc(F)c(-c3cccc4c3OC(C)(c3ccc(Cl)cc3F)O4)cc2F)nc2ccc(C(=O)O)cc21 771766 2-[[4-[2-(5-chloro- 2-pyridyl)-2- methyl-1,3- benzodioxol-4-yl]- 2,5-difluoro- phenyl]methyl]-3- (2- methoxyethyl) benzimidazole-5- carboxylic acid::US20250099431, Example 114 Glucagon-like peptide 1 receptor Homo sapiens 11.0 US Patent 10.7270/Q2V69QCG US20250099431 Ammann, SE; Brizgys, GJ; Cassidy, JS; Chin, E; Chou, C; Cottell, JJ; Hung, C; Kolahdouzan, K; Shore, DG; Szewczyk, SM; Taylor, JG; Thomas-Tran, R; Wright, NE; Yang, Z 3/27/2025 1/1/2026 Gilead Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7978&target=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771766&enzyme=Glucagon-like+peptide+1+receptor&column=ki&startPg=0&Increment=50&submit=Search 156813687 523184436 1 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS 7FIM,9J1P,9IVM,9IVG,8YWF,8YW3,8WG7,8JIR,8JIP,7VBI,7VBH,7EVM,7E14,7DUR,7DUQ,8JIS,6GB1,5E94,3IOL,4ZGM,3C5T,3C59,5OTX,5OTW,5OTV,5OTU,5OTT Glucagon-like peptide 1 receptor GLP1R_HUMAN P43220 Q2M229 Q99669