BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1134842 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |r| InChI=1S/C32H31ClN4O9/c1-46-32(45)23(10-11-27(38)39)35-31(44)26(16-28(40)41)37-29(42)24(13-17-6-7-18-4-2-3-5-19(18)12-17)36-30(43)25-15-20-14-21(33)8-9-22(20)34-25/h2-9,12,14-15,23-24,26,34H,10-11,13,16H2,1H3,(H,35,44)(H,36,43)(H,37,42)(H,38,39)(H,40,41) OSOKFNGDEFHCFQ-UHFFFAOYSA-N 50509815 CHEMBL4468897::US20250289848, Example 9 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 11000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509815&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155533295 440718400 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134843 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2c(Cl)cccc2[nH]1 |r| InChI=1S/C32H31ClN4O9/c1-46-32(45)23(11-12-27(38)39)35-31(44)26(16-28(40)41)37-29(42)24(14-17-9-10-18-5-2-3-6-19(18)13-17)36-30(43)25-15-20-21(33)7-4-8-22(20)34-25/h2-10,13,15,23-24,26,34H,11-12,14,16H2,1H3,(H,35,44)(H,36,43)(H,37,42)(H,38,39)(H,40,41) IRMZYOXXFZQATK-UHFFFAOYSA-N 50509826 CHEMBL4552947::US20250289848, Example 10 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 15000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509826&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155556130 440718411 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134844 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2ccc(Cl)cc2[nH]1 |r| InChI=1S/C32H31ClN4O9/c1-46-32(45)22(10-11-27(38)39)35-31(44)26(16-28(40)41)37-29(42)24(13-17-6-7-18-4-2-3-5-19(18)12-17)36-30(43)25-14-20-8-9-21(33)15-23(20)34-25/h2-9,12,14-15,22,24,26,34H,10-11,13,16H2,1H3,(H,35,44)(H,36,43)(H,37,42)(H,38,39)(H,40,41) NKBZPLGOOUCKMP-UHFFFAOYSA-N 50509791 CHEMBL4542718::US20250289848, Example 11 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 89000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509791&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155551766 440718376 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134845 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(F)ccc2[nH]1 |r| InChI=1S/C32H31FN4O9/c1-46-32(45)23(10-11-27(38)39)35-31(44)26(16-28(40)41)37-29(42)24(13-17-6-7-18-4-2-3-5-19(18)12-17)36-30(43)25-15-20-14-21(33)8-9-22(20)34-25/h2-9,12,14-15,23-24,26,34H,10-11,13,16H2,1H3,(H,35,44)(H,36,43)(H,37,42)(H,38,39)(H,40,41) JGDXTTNMWRFVEP-UHFFFAOYSA-N 50509784 CHEMBL4449274::US20250289848, Example 12 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 89000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509784 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509784&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155520694 440718369 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134846 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Br)ccc2[nH]1 |r| InChI=1S/C32H31BrN4O9/c1-46-32(45)23(10-11-27(38)39)35-31(44)26(16-28(40)41)37-29(42)24(13-17-6-7-18-4-2-3-5-19(18)12-17)36-30(43)25-15-20-14-21(33)8-9-22(20)34-25/h2-9,12,14-15,23-24,26,34H,10-11,13,16H2,1H3,(H,35,44)(H,36,43)(H,37,42)(H,38,39)(H,40,41) FRYKISPBUWJXIV-UHFFFAOYSA-N 50509792 CHEMBL4463747::US20250289848, Example 13 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 16000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509792 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509792&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155529863 440718377 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134847 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(C)ccc2[nH]1 |r| InChI=1S/C33H34N4O9/c1-18-7-10-23-22(13-18)16-26(34-23)31(43)36-25(15-19-8-9-20-5-3-4-6-21(20)14-19)30(42)37-27(17-29(40)41)32(44)35-24(33(45)46-2)11-12-28(38)39/h3-10,13-14,16,24-25,27,34H,11-12,15,17H2,1-2H3,(H,35,44)(H,36,43)(H,37,42)(H,38,39)(H,40,41) LZBSVRAXQXTPNA-UHFFFAOYSA-N 50509783 CHEMBL4451028::US20250289848, Example 14 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) >100000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509783&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155522353 440718368 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134848 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(OC)ccc2[nH]1 |r| InChI=1S/C33H34N4O10/c1-46-22-9-10-23-21(15-22)16-26(34-23)31(43)36-25(14-18-7-8-19-5-3-4-6-20(19)13-18)30(42)37-27(17-29(40)41)32(44)35-24(33(45)47-2)11-12-28(38)39/h3-10,13,15-16,24-25,27,34H,11-12,14,17H2,1-2H3,(H,35,44)(H,36,43)(H,37,42)(H,38,39)(H,40,41) ADIUJMKHFVRRLD-UHFFFAOYSA-N 50509816 CHEMBL4582542::US20250289848, Example 15 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) >100000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509816 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509816&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155561933 440718401 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134849 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(ccc2[nH]1)C(F)(F)F |r| InChI=1S/C33H31F3N4O9/c1-49-32(48)23(10-11-27(41)42)38-31(47)26(16-28(43)44)40-29(45)24(13-17-6-7-18-4-2-3-5-19(18)12-17)39-30(46)25-15-20-14-21(33(34,35)36)8-9-22(20)37-25/h2-9,12,14-15,23-24,26,37H,10-11,13,16H2,1H3,(H,38,47)(H,39,46)(H,40,45)(H,41,42)(H,43,44) QBRLQHMQCXXKJI-UHFFFAOYSA-N 50509793 CHEMBL4590503::US20250289848, Example 16 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 12000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509793 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509793&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155567749 440718378 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134850 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(ccc2[nH]1)[N+]([O-])=O |r| InChI=1S/C32H31N5O11/c1-48-32(45)23(10-11-27(38)39)34-31(44)26(16-28(40)41)36-29(42)24(13-17-6-7-18-4-2-3-5-19(18)12-17)35-30(43)25-15-20-14-21(37(46)47)8-9-22(20)33-25/h2-9,12,14-15,23-24,26,33H,10-11,13,16H2,1H3,(H,34,44)(H,35,43)(H,36,42)(H,38,39)(H,40,41) QFOGNXBVUMVUOM-UHFFFAOYSA-N 50509779 CHEMBL4451526::US20250289848, Example 17 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 17000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509779 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509779&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155522369 440718364 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134851 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)cc(Cl)c2[nH]1 |r| InChI=1S/C32H30Cl2N4O9/c1-47-32(46)22(8-9-26(39)40)36-31(45)25(15-27(41)42)38-29(43)23(11-16-6-7-17-4-2-3-5-18(17)10-16)37-30(44)24-13-19-12-20(33)14-21(34)28(19)35-24/h2-7,10,12-14,22-23,25,35H,8-9,11,15H2,1H3,(H,36,45)(H,37,44)(H,38,43)(H,39,40)(H,41,42) NCWWNUMSRYPHRB-UHFFFAOYSA-N 50509794 CHEMBL4452305::US20250289848, Example 18 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 9700 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509794 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509794&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155523009 440718379 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134852 COC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2c(Cl)cc(Cl)cc2[nH]1 |r| InChI=1S/C32H30Cl2N4O9/c1-47-32(46)22(8-9-27(39)40)36-31(45)26(15-28(41)42)38-29(43)24(11-16-6-7-17-4-2-3-5-18(17)10-16)37-30(44)25-14-20-21(34)12-19(33)13-23(20)35-25/h2-7,10,12-14,22,24,26,35H,8-9,11,15H2,1H3,(H,36,45)(H,37,44)(H,38,43)(H,39,40)(H,41,42) BIGIOGZXGNXUFF-UHFFFAOYSA-N 50509827 CHEMBL4544508::US20250289848, Example 19 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 4300 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509827&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155553111 440718412 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134853 CC(C)CCNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |r| InChI=1S/C36H40ClN5O8/c1-20(2)13-14-38-33(47)27(11-12-31(43)44)40-36(50)30(19-32(45)46)42-34(48)28(16-21-7-8-22-5-3-4-6-23(22)15-21)41-35(49)29-18-24-17-25(37)9-10-26(24)39-29/h3-10,15,17-18,20,27-28,30,39H,11-14,16,19H2,1-2H3,(H,38,47)(H,40,50)(H,41,49)(H,42,48)(H,43,44)(H,45,46) RSSMMCYCHHCXNL-UHFFFAOYSA-N 50509795 CHEMBL4437433::US20250289848, Example 20 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 8500 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509795&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155512566 440718380 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134854 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccccc1 |r| InChI=1S/C37H34ClN5O8/c38-25-12-13-27-24(18-25)19-30(40-27)36(50)42-29(17-21-10-11-22-6-4-5-7-23(22)16-21)35(49)43-31(20-33(46)47)37(51)41-28(14-15-32(44)45)34(48)39-26-8-2-1-3-9-26/h1-13,16,18-19,28-29,31,40H,14-15,17,20H2,(H,39,48)(H,41,51)(H,42,50)(H,43,49)(H,44,45)(H,46,47) MTCPLBYBZFINPU-UHFFFAOYSA-N 50509796 CHEMBL4535419::US20250289848, Example 21 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 3300 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509796 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509796&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155547949 440718381 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134855 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)NCc1ccccc1 |r| InChI=1S/C38H36ClN5O8/c39-27-12-13-28-26(18-27)19-31(41-28)37(51)43-30(17-23-10-11-24-8-4-5-9-25(24)16-23)36(50)44-32(20-34(47)48)38(52)42-29(14-15-33(45)46)35(49)40-21-22-6-2-1-3-7-22/h1-13,16,18-19,29-30,32,41H,14-15,17,20-21H2,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) XYAMUYWFKQNGDE-UHFFFAOYSA-N 50509831 CHEMBL4446715::US20250289848, Example 22 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 7600 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509831&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155518610 440718416 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134856 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)NCCc1ccccc1 |r| InChI=1S/C39H38ClN5O8/c40-28-12-13-29-27(20-28)21-32(42-29)38(52)44-31(19-24-10-11-25-8-4-5-9-26(25)18-24)37(51)45-33(22-35(48)49)39(53)43-30(14-15-34(46)47)36(50)41-17-16-23-6-2-1-3-7-23/h1-13,18,20-21,30-31,33,42H,14-17,19,22H2,(H,41,50)(H,43,53)(H,44,52)(H,45,51)(H,46,47)(H,48,49) POAMURKZWBFHRA-UHFFFAOYSA-N 50509797 CHEMBL4471868::US20250289848, Example 23 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 8900 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509797 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509797&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155535578 440718382 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134857 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccc(F)cc1 |r| InChI=1S/C37H33ClFN5O8/c38-24-7-12-27-23(17-24)18-30(41-27)36(51)43-29(16-20-5-6-21-3-1-2-4-22(21)15-20)35(50)44-31(19-33(47)48)37(52)42-28(13-14-32(45)46)34(49)40-26-10-8-25(39)9-11-26/h1-12,15,17-18,28-29,31,41H,13-14,16,19H2,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) ZJZXRKOOZKAZHS-UHFFFAOYSA-N 50509828 CHEMBL4591545::US20250289848, Example 24 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 4500 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509828 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509828&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155568218 440718413 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134858 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1cccc(F)c1 |r| InChI=1S/C37H33ClFN5O8/c38-24-10-11-27-23(16-24)17-30(41-27)36(51)43-29(15-20-8-9-21-4-1-2-5-22(21)14-20)35(50)44-31(19-33(47)48)37(52)42-28(12-13-32(45)46)34(49)40-26-7-3-6-25(39)18-26/h1-11,14,16-18,28-29,31,41H,12-13,15,19H2,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) MSLWUPCPUHWXGO-UHFFFAOYSA-N 50509780 CHEMBL4538548::US20250289848, Example 25 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 3300 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509780&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155549143 440718365 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134859 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccccc1F |r| InChI=1S/C37H33ClFN5O8/c38-24-11-12-26-23(17-24)18-30(40-26)36(51)43-29(16-20-9-10-21-5-1-2-6-22(21)15-20)35(50)44-31(19-33(47)48)37(52)42-28(13-14-32(45)46)34(49)41-27-8-4-3-7-25(27)39/h1-12,15,17-18,28-29,31,40H,13-14,16,19H2,(H,41,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) GJSMPGYKCBOZLW-UHFFFAOYSA-N 50509798 CHEMBL4515538::US20250289848, Example 26 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 3600 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509798 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509798&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155539905 440718383 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134860 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccc(Cl)cc1 |r| InChI=1S/C37H33Cl2N5O8/c38-24-7-10-26(11-8-24)40-34(49)28(13-14-32(45)46)42-37(52)31(19-33(47)48)44-35(50)29(16-20-5-6-21-3-1-2-4-22(21)15-20)43-36(51)30-18-23-17-25(39)9-12-27(23)41-30/h1-12,15,17-18,28-29,31,41H,13-14,16,19H2,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) RKFWVKPDWPVSGT-UHFFFAOYSA-N 50509799 CHEMBL4532791::US20250289848, Example 27 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 2700 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509799 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509799&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155547268 440718384 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134861 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1cccc(Cl)c1 |r| InChI=1S/C37H33Cl2N5O8/c38-24-6-3-7-26(18-24)40-34(49)28(12-13-32(45)46)42-37(52)31(19-33(47)48)44-35(50)29(15-20-8-9-21-4-1-2-5-22(21)14-20)43-36(51)30-17-23-16-25(39)10-11-27(23)41-30/h1-11,14,16-18,28-29,31,41H,12-13,15,19H2,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) OTFLOKLOTVOQMO-UHFFFAOYSA-N 50509829 CHEMBL4456139::US20250289848, Example 28 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 3100 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509829&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155524335 440718414 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134862 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccccc1Cl |r| InChI=1S/C37H33Cl2N5O8/c38-24-11-12-26-23(17-24)18-30(40-26)36(51)43-29(16-20-9-10-21-5-1-2-6-22(21)15-20)35(50)44-31(19-33(47)48)37(52)42-28(13-14-32(45)46)34(49)41-27-8-4-3-7-25(27)39/h1-12,15,17-18,28-29,31,40H,13-14,16,19H2,(H,41,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) GCCSWHZMVKMSLS-UHFFFAOYSA-N 50509800 CHEMBL4561875::US20250289848, Example 29 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 9600 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509800 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509800&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155558775 440718385 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134863 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccc(cc1)C(F)(F)F |r| InChI=1S/C38H33ClF3N5O8/c39-25-9-12-27-23(17-25)18-30(44-27)36(54)46-29(16-20-5-6-21-3-1-2-4-22(21)15-20)35(53)47-31(19-33(50)51)37(55)45-28(13-14-32(48)49)34(52)43-26-10-7-24(8-11-26)38(40,41)42/h1-12,15,17-18,28-29,31,44H,13-14,16,19H2,(H,43,52)(H,45,55)(H,46,54)(H,47,53)(H,48,49)(H,50,51) HSAQITXXQNWTND-UHFFFAOYSA-N 50509801 CHEMBL4464433::US20250289848, Example 30 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 1900 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509801 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509801&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155530410 440718386 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134864 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1cccc(c1)C(F)(F)F |r| InChI=1S/C38H33ClF3N5O8/c39-25-10-11-27-23(16-25)17-30(44-27)36(54)46-29(15-20-8-9-21-4-1-2-5-22(21)14-20)35(53)47-31(19-33(50)51)37(55)45-28(12-13-32(48)49)34(52)43-26-7-3-6-24(18-26)38(40,41)42/h1-11,14,16-18,28-29,31,44H,12-13,15,19H2,(H,43,52)(H,45,55)(H,46,54)(H,47,53)(H,48,49)(H,50,51) FQNRPJFGWVMTSM-UHFFFAOYSA-N 50509802 CHEMBL4515157::US20250289848, Example 31 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 2300 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509802 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509802&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155539480 440718387 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134865 COc1ccc(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1 |r| InChI=1S/C38H36ClN5O9/c1-53-27-11-9-26(10-12-27)40-35(49)29(14-15-33(45)46)42-38(52)32(20-34(47)48)44-36(50)30(17-21-6-7-22-4-2-3-5-23(22)16-21)43-37(51)31-19-24-18-25(39)8-13-28(24)41-31/h2-13,16,18-19,29-30,32,41H,14-15,17,20H2,1H3,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) ITHCSJIXISFNRZ-UHFFFAOYSA-N 50509817 CHEMBL4565782::US20250289848, Example 32 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 2600 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509817&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155545293 440718402 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134866 COc1cccc(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)c2cc3cc(Cl)ccc3[nH]2)c1 |r| InChI=1S/C38H36ClN5O9/c1-53-27-8-4-7-26(19-27)40-35(49)29(13-14-33(45)46)42-38(52)32(20-34(47)48)44-36(50)30(16-21-9-10-22-5-2-3-6-23(22)15-21)43-37(51)31-18-24-17-25(39)11-12-28(24)41-31/h2-12,15,17-19,29-30,32,41H,13-14,16,20H2,1H3,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) GGYYSTJFHOEGEK-UHFFFAOYSA-N 50509818 CHEMBL4579221::US20250289848, Example 33 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 2400 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509818&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155565262 440718403 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1134867 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| InChI=1S/C38H33ClF3N5O9/c39-24-7-12-27-23(17-24)18-30(44-27)36(54)46-29(16-20-5-6-21-3-1-2-4-22(21)15-20)35(53)47-31(19-33(50)51)37(55)45-28(13-14-32(48)49)34(52)43-25-8-10-26(11-9-25)56-38(40,41)42/h1-12,15,17-18,28-29,31,44H,13-14,16,19H2,(H,43,52)(H,45,55)(H,46,54)(H,47,53)(H,48,49)(H,50,51) MLLGKYJIOWULMN-UHFFFAOYSA-N 50509781 CHEMBL4450852::US20250289848, Example 34 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 1900 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509781 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509781&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155522343 440718366 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1135203 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1cccc(OC(F)(F)F)c1 |r| InChI=1S/C38H33ClF3N5O9/c39-24-10-11-27-23(16-24)17-30(44-27)36(54)46-29(15-20-8-9-21-4-1-2-5-22(21)14-20)35(53)47-31(19-33(50)51)37(55)45-28(12-13-32(48)49)34(52)43-25-6-3-7-26(18-25)56-38(40,41)42/h1-11,14,16-18,28-29,31,44H,12-13,15,19H2,(H,43,52)(H,45,55)(H,46,54)(H,47,53)(H,48,49)(H,50,51) AWWNERDESHDLFP-UHFFFAOYSA-N 50509803 CHEMBL4449577::US20250289848, Example 35 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 2200 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509803 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509803&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155520646 440718388 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1135204 COc1cc(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc(OC)c1 |r| InChI=1S/C39H38ClN5O10/c1-54-27-17-26(18-28(19-27)55-2)41-36(50)30(11-12-34(46)47)43-39(53)33(20-35(48)49)45-37(51)31(14-21-7-8-22-5-3-4-6-23(22)13-21)44-38(52)32-16-24-15-25(40)9-10-29(24)42-32/h3-10,13,15-19,30-31,33,42H,11-12,14,20H2,1-2H3,(H,41,50)(H,43,53)(H,44,52)(H,45,51)(H,46,47)(H,48,49) QJCYFTPHOCCBEH-UHFFFAOYSA-N 50509833 CHEMBL4464915::US20250289848, Example 36 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 3300 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509833 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509833&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155530942 440718418 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1135205 COc1cc(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc(c1)C(F)(F)F |r| InChI=1S/C39H35ClF3N5O9/c1-57-27-17-24(39(41,42)43)16-26(18-27)44-35(53)29(10-11-33(49)50)46-38(56)32(19-34(51)52)48-36(54)30(13-20-6-7-21-4-2-3-5-22(21)12-20)47-37(55)31-15-23-14-25(40)8-9-28(23)45-31/h2-9,12,14-18,29-30,32,45H,10-11,13,19H2,1H3,(H,44,53)(H,46,56)(H,47,55)(H,48,54)(H,49,50)(H,51,52) BGHIDEKWEGCINK-UHFFFAOYSA-N 50509804 CHEMBL4455488::US20250289848, Example 37 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 2600 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509804&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155524482 440718389 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1135206 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccc2OCOc2c1 |r| InChI=1S/C38H34ClN5O10/c39-24-7-9-26-23(15-24)16-29(41-26)37(51)43-28(14-20-5-6-21-3-1-2-4-22(21)13-20)36(50)44-30(18-34(47)48)38(52)42-27(10-12-33(45)46)35(49)40-25-8-11-31-32(17-25)54-19-53-31/h1-9,11,13,15-17,27-28,30,41H,10,12,14,18-19H2,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) IENXRCIFUJDMLA-UHFFFAOYSA-N 50509819 CHEMBL4460073::US20250289848, Example 38 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 2500 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509819&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155527310 440718404 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137560 CC(C)C[C@H](NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)Nc1ccccc1 |r| InChI=1S/C30H34ClN5O8/c1-16(2)12-22(35-29(43)23-14-17-13-18(31)8-9-20(17)33-23)28(42)36-24(15-26(39)40)30(44)34-21(10-11-25(37)38)27(41)32-19-6-4-3-5-7-19/h3-9,13-14,16,21-22,24,33H,10-12,15H2,1-2H3,(H,32,41)(H,34,44)(H,35,43)(H,36,42)(H,37,38)(H,39,40) NROUDCXUFWEPLS-UHFFFAOYSA-N 50509820 CHEMBL4438567::US20250289848, Example 39 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 70000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509820&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155513400 440718405 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137561 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccccc1 |r| InChI=1S/C33H30Cl3N5O8/c34-19-7-9-23-18(14-19)15-26(38-23)32(48)40-25(13-17-6-8-21(35)22(36)12-17)31(47)41-27(16-29(44)45)33(49)39-24(10-11-28(42)43)30(46)37-20-4-2-1-3-5-20/h1-9,12,14-15,24-25,27,38H,10-11,13,16H2,(H,37,46)(H,39,49)(H,40,48)(H,41,47)(H,42,43)(H,44,45) NLEYLBDFJMEBQD-UHFFFAOYSA-N 50509805 CHEMBL4451874::US20250289848, Example 40 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 3700 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509805&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155522080 440718390 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137562 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccccc1 |r| InChI=1S/C33H31Cl2N5O8/c34-20-8-6-18(7-9-20)14-25(39-32(47)26-16-19-15-21(35)10-11-23(19)37-26)31(46)40-27(17-29(43)44)33(48)38-24(12-13-28(41)42)30(45)36-22-4-2-1-3-5-22/h1-11,15-16,24-25,27,37H,12-14,17H2,(H,36,45)(H,38,48)(H,39,47)(H,40,46)(H,41,42)(H,43,44) PWTMQAHQPJYWGG-UHFFFAOYSA-N 50509806 CHEMBL4552917::US20250289848, Example 41 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 11000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509806&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155555958 440718391 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137563 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1Cl)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccccc1 |r| InChI=1S/C33H31Cl2N5O8/c34-20-10-11-23-19(14-20)16-25(37-23)31(46)39-26(15-18-6-4-5-9-22(18)35)32(47)40-27(17-29(43)44)33(48)38-24(12-13-28(41)42)30(45)36-21-7-2-1-3-8-21/h1-11,14,16,24,26-27,37H,12-13,15,17H2,(H,36,45)(H,38,48)(H,39,46)(H,40,47)(H,41,42)(H,43,44) ZEBLUANOECYZRT-UHFFFAOYSA-N 50509777 CHEMBL4440977::US20250289848, Example 42 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 14000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509777&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155514892 440718362 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137564 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(cc1)C(F)(F)F)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccccc1 |r| InChI=1S/C34H31ClF3N5O8/c35-21-10-11-23-19(15-21)16-26(40-23)32(50)42-25(14-18-6-8-20(9-7-18)34(36,37)38)31(49)43-27(17-29(46)47)33(51)41-24(12-13-28(44)45)30(48)39-22-4-2-1-3-5-22/h1-11,15-16,24-25,27,40H,12-14,17H2,(H,39,48)(H,41,51)(H,42,50)(H,43,49)(H,44,45)(H,46,47) REYHMYNPLCVYJN-UHFFFAOYSA-N 50509785 CHEMBL4471027::US20250289848, Example 43 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 9300 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509785 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509785&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155534911 440718370 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137565 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(cc1)C#N)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccccc1 |r| InChI=1S/C34H31ClN6O8/c35-22-10-11-24-21(15-22)16-27(38-24)33(48)40-26(14-19-6-8-20(18-36)9-7-19)32(47)41-28(17-30(44)45)34(49)39-25(12-13-29(42)43)31(46)37-23-4-2-1-3-5-23/h1-11,15-16,25-26,28,38H,12-14,17H2,(H,37,46)(H,39,49)(H,40,48)(H,41,47)(H,42,43)(H,44,45) CGIRLPKWGZMBGL-UHFFFAOYSA-N 50509821 CHEMBL4456175::US20250289848, Example 44 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 20000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509821&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155524656 440718406 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137566 COc1ccc(C[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)Nc2ccccc2)cc1 |r| InChI=1S/C34H34ClN5O9/c1-49-23-10-7-19(8-11-23)15-26(39-33(47)27-17-20-16-21(35)9-12-24(20)37-27)32(46)40-28(18-30(43)44)34(48)38-25(13-14-29(41)42)31(45)36-22-5-3-2-4-6-22/h2-12,16-17,25-26,28,37H,13-15,18H2,1H3,(H,36,45)(H,38,48)(H,39,47)(H,40,46)(H,41,42)(H,43,44) FLILQIHLGUFGSZ-UHFFFAOYSA-N 50509832 CHEMBL4442839::US20250289848, Example 45 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 25000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509832 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509832&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155516253 440718417 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137567 OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccccc1 |r| InChI=1S/C37H34ClN5O8/c38-24-13-14-27-23(17-24)19-29(40-27)35(49)42-30(18-22-9-6-8-21-7-4-5-12-26(21)22)36(50)43-31(20-33(46)47)37(51)41-28(15-16-32(44)45)34(48)39-25-10-2-1-3-11-25/h1-14,17,19,28,30-31,40H,15-16,18,20H2,(H,39,48)(H,41,51)(H,42,49)(H,43,50)(H,44,45)(H,46,47) MCBHSLWAKOPLPC-UHFFFAOYSA-N 50509807 CHEMBL4560197::US20250289848, Example 46 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 2900 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509807 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509807&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 146671571 440718392 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137568 COc1cccc(NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)c2cc3cc(Cl)ccc3[nH]2)c1 |r| InChI=1S/C38H36ClN5O9/c1-53-27-8-4-7-26(19-27)40-35(49)29(13-14-33(45)46)42-38(52)32(20-34(47)48)44-36(50)30(16-21-9-10-22-5-2-3-6-23(22)15-21)43-37(51)31-18-24-17-25(39)11-12-28(24)41-31/h2-12,15,17-19,29-30,32,41H,13-14,16,20H2,1H3,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) GGYYSTJFHOEGEK-UHFFFAOYSA-N 50509808 CHEMBL4583661::US20250289848, Example 47 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 10000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509808 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509808&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155562046 440718393 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137569 COc1cccc(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)c2cc3cc(Cl)ccc3[nH]2)c1 |r| InChI=1S/C38H36ClN5O9/c1-53-27-8-4-7-26(19-27)40-35(49)29(13-14-33(45)46)42-38(52)32(20-34(47)48)44-36(50)30(16-21-9-10-22-5-2-3-6-23(22)15-21)43-37(51)31-18-24-17-25(39)11-12-28(24)41-31/h2-12,15,17-19,29-30,32,41H,13-14,16,20H2,1H3,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) GGYYSTJFHOEGEK-UHFFFAOYSA-N 50509822 CHEMBL4590084::US20250289848, Example 48 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 6600 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509822&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155567741 440718407 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137570 COc1cccc(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)c2cc3cc(Cl)ccc3[nH]2)c1 |r| InChI=1S/C38H36ClN5O9/c1-53-27-8-4-7-26(19-27)40-35(49)29(13-14-33(45)46)42-38(52)32(20-34(47)48)44-36(50)30(16-21-9-10-22-5-2-3-6-23(22)15-21)43-37(51)31-18-24-17-25(39)11-12-28(24)41-31/h2-12,15,17-19,29-30,32,41H,13-14,16,20H2,1H3,(H,40,49)(H,42,52)(H,43,51)(H,44,50)(H,45,46)(H,47,48) GGYYSTJFHOEGEK-UHFFFAOYSA-N 50509830 CHEMBL4437760::US20250289848, Example 49 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 8000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509830 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509830&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155512758 440718415 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137571 NC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| InChI=1S/C38H34ClF3N6O8/c39-24-7-12-27-23(17-24)18-30(45-27)36(54)47-29(16-20-5-6-21-3-1-2-4-22(21)15-20)35(53)48-31(19-33(50)51)37(55)46-28(13-14-32(43)49)34(52)44-25-8-10-26(11-9-25)56-38(40,41)42/h1-12,15,17-18,28-29,31,45H,13-14,16,19H2,(H2,43,49)(H,44,52)(H,46,55)(H,47,54)(H,48,53)(H,50,51) AZCMXIRLGHHFQM-UHFFFAOYSA-N 50509809 CHEMBL4483303::US20250289848, Example 50 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 6700 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509809&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 146670445 440718394 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137572 NC(=O)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](CCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| InChI=1S/C38H34ClF3N6O8/c39-24-7-12-27-23(17-24)18-30(45-27)36(54)47-29(16-20-5-6-21-3-1-2-4-22(21)15-20)35(53)48-31(19-32(43)49)37(55)46-28(13-14-33(50)51)34(52)44-25-8-10-26(11-9-25)56-38(40,41)42/h1-12,15,17-18,28-29,31,45H,13-14,16,19H2,(H2,43,49)(H,44,52)(H,46,55)(H,47,54)(H,48,53)(H,50,51) RIWCFWGTWUBOMI-UHFFFAOYSA-N 50509778 CHEMBL4584378::US20250289848, Example 51 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 10000 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509778 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509778&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 146671572 440718363 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137573 OC(=O)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](Cc1nn[nH]n1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| InChI=1S/C37H31ClF3N9O7/c38-23-7-12-26-22(15-23)16-28(43-26)35(55)44-27(14-19-5-6-20-3-1-2-4-21(20)13-19)34(54)46-30(18-32(51)52)36(56)45-29(17-31-47-49-50-48-31)33(53)42-24-8-10-25(11-9-24)57-37(39,40)41/h1-13,15-16,27,29-30,43H,14,17-18H2,(H,42,53)(H,44,55)(H,45,56)(H,46,54)(H,51,52)(H,47,48,49,50) NWIKOXMHEHTGNY-UHFFFAOYSA-N 50509810 CHEMBL4464142::US20250289848, Example 52 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 1500 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509810 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509810&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155529836 440718395 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137574 OC(=O)CC[C@H](NC(=O)[C@H](Cc1nn[nH]n1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| InChI=1S/C38H33ClF3N9O7/c39-24-7-12-27-23(17-24)18-30(44-27)36(56)46-29(16-20-5-6-21-3-1-2-4-22(21)15-20)35(55)47-31(19-32-48-50-51-49-32)37(57)45-28(13-14-33(52)53)34(54)43-25-8-10-26(11-9-25)58-38(40,41)42/h1-12,15,17-18,28-29,31,44H,13-14,16,19H2,(H,43,54)(H,45,57)(H,46,56)(H,47,55)(H,52,53)(H,48,49,50,51) OQIIPRFMLCIWTR-UHFFFAOYSA-N 50509813 CHEMBL4451478::US20250289848, Example 53 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 640 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509813&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155522143 440718398 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137575 NC(=O)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](Cc1nn[nH]n1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| InChI=1S/C37H32ClF3N10O6/c38-23-7-12-26-22(15-23)16-28(44-26)35(55)45-27(14-19-5-6-20-3-1-2-4-21(20)13-19)34(54)46-29(17-31(42)52)36(56)47-30(18-32-48-50-51-49-32)33(53)43-24-8-10-25(11-9-24)57-37(39,40)41/h1-13,15-16,27,29-30,44H,14,17-18H2,(H2,42,52)(H,43,53)(H,45,55)(H,46,54)(H,47,56)(H,48,49,50,51) MDDRPRKKKZSHPN-UHFFFAOYSA-N 50509786 CHEMBL4577989::US20250289848, Example 54 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 4900 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509786 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509786&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155564679 440718371 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137576 NC(=O)CC[C@H](NC(=O)[C@H](Cc1nn[nH]n1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| InChI=1S/C38H34ClF3N10O6/c39-24-7-12-27-23(17-24)18-30(45-27)36(56)47-29(16-20-5-6-21-3-1-2-4-22(21)15-20)35(55)48-31(19-33-49-51-52-50-33)37(57)46-28(13-14-32(43)53)34(54)44-25-8-10-26(11-9-25)58-38(40,41)42/h1-12,15,17-18,28-29,31,45H,13-14,16,19H2,(H2,43,53)(H,44,54)(H,46,57)(H,47,56)(H,48,55)(H,49,50,51,52) OLLOUZQFLAVNEZ-UHFFFAOYSA-N 50509823 CHEMBL4561695::US20250289848, Example 55 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 3900 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509823&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155559087 440718408 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137577 CCOC(=O)CC[C@H](NC(=O)[C@H](Cc1nn[nH]n1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| InChI=1S/C40H37ClF3N9O7/c1-2-59-35(54)16-15-30(36(55)45-27-10-12-28(13-11-27)60-40(42,43)44)47-39(58)33(21-34-50-52-53-51-34)49-37(56)31(18-22-7-8-23-5-3-4-6-24(23)17-22)48-38(57)32-20-25-19-26(41)9-14-29(25)46-32/h3-14,17,19-20,30-31,33,46H,2,15-16,18,21H2,1H3,(H,45,55)(H,47,58)(H,48,57)(H,49,56)(H,50,51,52,53) PTQJJNZDVAFMSL-UHFFFAOYSA-N 50509811 CHEMBL4465565::US20250289848, Example 56 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 5200 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509811&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155531142 440718396 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8 1137578 OC(=O)CC[C@H](NC(=O)[C@H](Cc1nn[nH]n1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cc2c(Cl)cc(Cl)cc2[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| InChI=1S/C38H32Cl2F3N9O7/c39-22-15-26(40)25-17-30(45-28(25)16-22)36(57)47-29(14-19-5-6-20-3-1-2-4-21(20)13-19)35(56)48-31(18-32-49-51-52-50-32)37(58)46-27(11-12-33(53)54)34(55)44-23-7-9-24(10-8-23)59-38(41,42)43/h1-10,13,15-17,27,29,31,45H,11-12,14,18H2,(H,44,55)(H,46,58)(H,47,57)(H,48,56)(H,53,54)(H,49,50,51,52) OYKFNVVXTZPSDB-UHFFFAOYSA-N 50509812 CHEMBL4548532::US20250289848, Example 57 Catenin beta-1 (138-781), Transcription Factor 4 (7-51), and Cadherin-1 (819-873) 440 US Patent 10.7270/Q2F194HS US20250289848 JI, H 9/18/2025 1/4/2026 H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509812 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=481&target=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509812&enzyme=Catenin+beta-1+%28138-781%29%2C+Transcription+Factor+4+%287-51%29%2C+and+Cadherin-1+%28819-873%29&column=ki&startPg=0&Increment=50&submit=Search 155545420 440718397 3 NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL 2Z6H,8Z61,8Z5J,8Z10,8Z0U,8Y14,8Y0P,8Y0G,3OUX,3OUW,4EVT,4EVP,4EVA,4EV9,4EV8,1V18,1M1E,1JPP,1I7X,1I7W,1JPW,1QZ7,7AR4,8EIC,8EIB,8EIA,8EI9,7UWO,8RU3,1TH1,1G3J,7ZRB,3TX7,1JDH,7UWI,8RU4,1T08,4DJS,2BCT,1LUJ,3BCT,3SLA,7AFW,3SL9,4ONS Catenin beta-1 CTNB1_HUMAN P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391 MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE Transcription factor 4 ITF2_HUMAN P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441 DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA Cadherin-1 CADH1_HUMAN P12830 A8K1U7 Q13799 Q14216 Q15855 Q16194 Q4PJ14 Q9UII8