BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1137595 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)C3CC3)C4)n2n1)C1CC1 771878 US12419873, Compound 1-7 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 38.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771878&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 177858803 523184548 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137596 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)C3CC3)C4)n2n1)C1CC1 771878 US12419873, Compound 1-7 Tyrosine-protein kinase JAK1 Homo sapiens 6.00 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771878&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 177858803 523184548 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137597 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)C3CC3)C4)n2n1)C1CC1 771878 US12419873, Compound 1-7 Tyrosine-protein kinase JAK2 Homo sapiens 60.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771878&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 177858803 523184548 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137598 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)C3CC3)C4)n2n1)C1CC1 771878 US12419873, Compound 1-7 Tyrosine-protein kinase JAK3 Homo sapiens 3834 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771878&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 177858803 523184548 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137599 N#CC1CC1C(=O)N1CC2(CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2)C1 771879 US12419873, Compound 1-8 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 27.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771879&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 176594021 523184549 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137600 N#CC1CC1C(=O)N1CC2(CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2)C1 771879 US12419873, Compound 1-8 Tyrosine-protein kinase JAK1 Homo sapiens 14.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771879&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 176594021 523184549 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137601 N#CC1CC1C(=O)N1CC2(CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2)C1 771879 US12419873, Compound 1-8 Tyrosine-protein kinase JAK2 Homo sapiens 78.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771879&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 176594021 523184549 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137602 N#CC1CC1C(=O)N1CC2(CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2)C1 771879 US12419873, Compound 1-8 Tyrosine-protein kinase JAK3 Homo sapiens 2939 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=771879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=771879&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 176594021 523184549 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137603 FC1(CC1)C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C22H26FN5O2/c23-22(10-11-22)19(30)27-12-21(13-27)8-6-14(7-9-21)16-2-1-3-17-24-20(26-28(16)17)25-18(29)15-4-5-15/h1-3,14-15H,4-13H2,(H,25,26,29) SQYLALYCIXZGJX-UHFFFAOYSA-N 50602438 CHEMBL5203588::US11919896, Compound 1-9::US12419873, Compound 1-9 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 366 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602438&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408568 482613289 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137604 FC1(CC1)C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C22H26FN5O2/c23-22(10-11-22)19(30)27-12-21(13-27)8-6-14(7-9-21)16-2-1-3-17-24-20(26-28(16)17)25-18(29)15-4-5-15/h1-3,14-15H,4-13H2,(H,25,26,29) SQYLALYCIXZGJX-UHFFFAOYSA-N 50602438 CHEMBL5203588::US11919896, Compound 1-9::US12419873, Compound 1-9 Tyrosine-protein kinase JAK1 Homo sapiens 34.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602438&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408568 482613289 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137605 FC1(CC1)C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C22H26FN5O2/c23-22(10-11-22)19(30)27-12-21(13-27)8-6-14(7-9-21)16-2-1-3-17-24-20(26-28(16)17)25-18(29)15-4-5-15/h1-3,14-15H,4-13H2,(H,25,26,29) SQYLALYCIXZGJX-UHFFFAOYSA-N 50602438 CHEMBL5203588::US11919896, Compound 1-9::US12419873, Compound 1-9 Tyrosine-protein kinase JAK2 Homo sapiens 315 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602438&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408568 482613289 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137606 FC1(CC1)C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C22H26FN5O2/c23-22(10-11-22)19(30)27-12-21(13-27)8-6-14(7-9-21)16-2-1-3-17-24-20(26-28(16)17)25-18(29)15-4-5-15/h1-3,14-15H,4-13H2,(H,25,26,29) SQYLALYCIXZGJX-UHFFFAOYSA-N 50602438 CHEMBL5203588::US11919896, Compound 1-9::US12419873, Compound 1-9 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602438&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408568 482613289 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137607 FC(F)(F)CC(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H24F3N5O2/c22-21(23,24)10-17(30)28-11-20(12-28)8-6-13(7-9-20)15-2-1-3-16-25-19(27-29(15)16)26-18(31)14-4-5-14/h1-3,13-14H,4-12H2,(H,26,27,31) MWPWAFLAKBGKNY-UHFFFAOYSA-N 50602434 CHEMBL5180245::US11919896, Compound 1-10::US12419873, Compound 1-10 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 311 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602434&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408571 482613285 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137608 FC(F)(F)CC(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H24F3N5O2/c22-21(23,24)10-17(30)28-11-20(12-28)8-6-13(7-9-20)15-2-1-3-16-25-19(27-29(15)16)26-18(31)14-4-5-14/h1-3,13-14H,4-12H2,(H,26,27,31) MWPWAFLAKBGKNY-UHFFFAOYSA-N 50602434 CHEMBL5180245::US11919896, Compound 1-10::US12419873, Compound 1-10 Tyrosine-protein kinase JAK1 Homo sapiens 32.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602434&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408571 482613285 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137609 FC(F)(F)CC(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H24F3N5O2/c22-21(23,24)10-17(30)28-11-20(12-28)8-6-13(7-9-20)15-2-1-3-16-25-19(27-29(15)16)26-18(31)14-4-5-14/h1-3,13-14H,4-12H2,(H,26,27,31) MWPWAFLAKBGKNY-UHFFFAOYSA-N 50602434 CHEMBL5180245::US11919896, Compound 1-10::US12419873, Compound 1-10 Tyrosine-protein kinase JAK2 Homo sapiens 426 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602434&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408571 482613285 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137610 FC(F)(F)CC(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H24F3N5O2/c22-21(23,24)10-17(30)28-11-20(12-28)8-6-13(7-9-20)15-2-1-3-16-25-19(27-29(15)16)26-18(31)14-4-5-14/h1-3,13-14H,4-12H2,(H,26,27,31) MWPWAFLAKBGKNY-UHFFFAOYSA-N 50602434 CHEMBL5180245::US11919896, Compound 1-10::US12419873, Compound 1-10 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602434&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408571 482613285 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137611 O=C(Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(CC4)C#N)CC3)n2n1)C1CC1 InChI=1S/C23H26N6O2/c24-12-23(10-11-23)20(31)28-13-22(14-28)8-6-15(7-9-22)17-2-1-3-18-25-21(27-29(17)18)26-19(30)16-4-5-16/h1-3,15-16H,4-11,13-14H2,(H,26,27,30) RMQNBYVKJXQSLH-UHFFFAOYSA-N 50602439 CHEMBL5172426::US11919896, Compound 1-11::US12419873, Compound 1-11 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 18.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602439&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408516 482613290 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137612 O=C(Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(CC4)C#N)CC3)n2n1)C1CC1 InChI=1S/C23H26N6O2/c24-12-23(10-11-23)20(31)28-13-22(14-28)8-6-15(7-9-22)17-2-1-3-18-25-21(27-29(17)18)26-19(30)16-4-5-16/h1-3,15-16H,4-11,13-14H2,(H,26,27,30) RMQNBYVKJXQSLH-UHFFFAOYSA-N 50602439 CHEMBL5172426::US11919896, Compound 1-11::US12419873, Compound 1-11 Tyrosine-protein kinase JAK1 Homo sapiens 15.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602439&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408516 482613290 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137613 O=C(Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(CC4)C#N)CC3)n2n1)C1CC1 InChI=1S/C23H26N6O2/c24-12-23(10-11-23)20(31)28-13-22(14-28)8-6-15(7-9-22)17-2-1-3-18-25-21(27-29(17)18)26-19(30)16-4-5-16/h1-3,15-16H,4-11,13-14H2,(H,26,27,30) RMQNBYVKJXQSLH-UHFFFAOYSA-N 50602439 CHEMBL5172426::US11919896, Compound 1-11::US12419873, Compound 1-11 Tyrosine-protein kinase JAK2 Homo sapiens 198 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602439&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408516 482613290 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137614 O=C(Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(CC4)C#N)CC3)n2n1)C1CC1 InChI=1S/C23H26N6O2/c24-12-23(10-11-23)20(31)28-13-22(14-28)8-6-15(7-9-22)17-2-1-3-18-25-21(27-29(17)18)26-19(30)16-4-5-16/h1-3,15-16H,4-11,13-14H2,(H,26,27,30) RMQNBYVKJXQSLH-UHFFFAOYSA-N 50602439 CHEMBL5172426::US11919896, Compound 1-11::US12419873, Compound 1-11 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602439&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408516 482613290 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137615 FC1(F)C[C@@H]1C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C22H25F2N5O2/c23-22(24)10-15(22)19(31)28-11-21(12-28)8-6-13(7-9-21)16-2-1-3-17-25-20(27-29(16)17)26-18(30)14-4-5-14/h1-3,13-15H,4-12H2,(H,26,27,30) ZOUHWHPRPDJDQE-UHFFFAOYSA-N 50602436 CHEMBL5181588::US11919896, Compound 1-12::US12419873, Compound 1-12 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 360 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602436&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408624 482613287 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137616 FC1(F)C[C@@H]1C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C22H25F2N5O2/c23-22(24)10-15(22)19(31)28-11-21(12-28)8-6-13(7-9-21)16-2-1-3-17-25-20(27-29(16)17)26-18(30)14-4-5-14/h1-3,13-15H,4-12H2,(H,26,27,30) ZOUHWHPRPDJDQE-UHFFFAOYSA-N 50602436 CHEMBL5181588::US11919896, Compound 1-12::US12419873, Compound 1-12 Tyrosine-protein kinase JAK1 Homo sapiens 45.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602436&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408624 482613287 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137617 FC1(F)C[C@@H]1C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C22H25F2N5O2/c23-22(24)10-15(22)19(31)28-11-21(12-28)8-6-13(7-9-21)16-2-1-3-17-25-20(27-29(16)17)26-18(30)14-4-5-14/h1-3,13-15H,4-12H2,(H,26,27,30) ZOUHWHPRPDJDQE-UHFFFAOYSA-N 50602436 CHEMBL5181588::US11919896, Compound 1-12::US12419873, Compound 1-12 Tyrosine-protein kinase JAK2 Homo sapiens 527 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602436&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408624 482613287 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137618 FC1(F)C[C@@H]1C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C22H25F2N5O2/c23-22(24)10-15(22)19(31)28-11-21(12-28)8-6-13(7-9-21)16-2-1-3-17-25-20(27-29(16)17)26-18(30)14-4-5-14/h1-3,13-15H,4-12H2,(H,26,27,30) ZOUHWHPRPDJDQE-UHFFFAOYSA-N 50602436 CHEMBL5181588::US11919896, Compound 1-12::US12419873, Compound 1-12 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602436&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408624 482613287 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137619 FC1(F)C[C@H]1C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C22H25F2N5O2/c23-22(24)10-15(22)19(31)28-11-21(12-28)8-6-13(7-9-21)16-2-1-3-17-25-20(27-29(16)17)26-18(30)14-4-5-14/h1-3,13-15H,4-12H2,(H,26,27,30) ZOUHWHPRPDJDQE-UHFFFAOYSA-N 50602437 CHEMBL5172397::US11919896, Compound 1-13::US12419873, Compound 1-13 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 36.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602437&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408604 482613288 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137620 FC1(F)C[C@H]1C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C22H25F2N5O2/c23-22(24)10-15(22)19(31)28-11-21(12-28)8-6-13(7-9-21)16-2-1-3-17-25-20(27-29(16)17)26-18(30)14-4-5-14/h1-3,13-15H,4-12H2,(H,26,27,30) ZOUHWHPRPDJDQE-UHFFFAOYSA-N 50602437 CHEMBL5172397::US11919896, Compound 1-13::US12419873, Compound 1-13 Tyrosine-protein kinase JAK1 Homo sapiens 3.00 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602437&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408604 482613288 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137621 FC1(F)C[C@H]1C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C22H25F2N5O2/c23-22(24)10-15(22)19(31)28-11-21(12-28)8-6-13(7-9-21)16-2-1-3-17-25-20(27-29(16)17)26-18(30)14-4-5-14/h1-3,13-15H,4-12H2,(H,26,27,30) ZOUHWHPRPDJDQE-UHFFFAOYSA-N 50602437 CHEMBL5172397::US11919896, Compound 1-13::US12419873, Compound 1-13 Tyrosine-protein kinase JAK2 Homo sapiens 37.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602437&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408604 482613288 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137622 FC1(F)C[C@H]1C(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C22H25F2N5O2/c23-22(24)10-15(22)19(31)28-11-21(12-28)8-6-13(7-9-21)16-2-1-3-17-25-20(27-29(16)17)26-18(30)14-4-5-14/h1-3,13-15H,4-12H2,(H,26,27,30) ZOUHWHPRPDJDQE-UHFFFAOYSA-N 50602437 CHEMBL5172397::US11919896, Compound 1-13::US12419873, Compound 1-13 Tyrosine-protein kinase JAK3 Homo sapiens 1517 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602437&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408604 482613288 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137623 FC(F)CC(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H25F2N5O2/c22-16(23)10-18(29)27-11-21(12-27)8-6-13(7-9-21)15-2-1-3-17-24-20(26-28(15)17)25-19(30)14-4-5-14/h1-3,13-14,16H,4-12H2,(H,25,26,30) BHNDJUYEDBRJRX-UHFFFAOYSA-N 50602440 CHEMBL5201720::US11919896, Compound 1-14::US12419873, Compound 1-14 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 134 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602440 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602440&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408513 482613291 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137624 FC(F)CC(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H25F2N5O2/c22-16(23)10-18(29)27-11-21(12-27)8-6-13(7-9-21)15-2-1-3-17-24-20(26-28(15)17)25-19(30)14-4-5-14/h1-3,13-14,16H,4-12H2,(H,25,26,30) BHNDJUYEDBRJRX-UHFFFAOYSA-N 50602440 CHEMBL5201720::US11919896, Compound 1-14::US12419873, Compound 1-14 Tyrosine-protein kinase JAK1 Homo sapiens 12.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602440 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602440&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408513 482613291 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137625 FC(F)CC(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H25F2N5O2/c22-16(23)10-18(29)27-11-21(12-27)8-6-13(7-9-21)15-2-1-3-17-24-20(26-28(15)17)25-19(30)14-4-5-14/h1-3,13-14,16H,4-12H2,(H,25,26,30) BHNDJUYEDBRJRX-UHFFFAOYSA-N 50602440 CHEMBL5201720::US11919896, Compound 1-14::US12419873, Compound 1-14 Tyrosine-protein kinase JAK2 Homo sapiens 144 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602440 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602440&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408513 482613291 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137626 FC(F)CC(=O)N1CC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H25F2N5O2/c22-16(23)10-18(29)27-11-21(12-27)8-6-13(7-9-21)15-2-1-3-17-24-20(26-28(15)17)25-19(30)14-4-5-14/h1-3,13-14,16H,4-12H2,(H,25,26,30) BHNDJUYEDBRJRX-UHFFFAOYSA-N 50602440 CHEMBL5201720::US11919896, Compound 1-14::US12419873, Compound 1-14 Tyrosine-protein kinase JAK3 Homo sapiens 5035 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602440 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602440&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408513 482613291 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137627 CC(C)(C#N)CC(=O)N1CC2(CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2)C1 772406 US12419873, Compound 1-15 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 106 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772406&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 177858816 523185076 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137628 CC(C)(C#N)CC(=O)N1CC2(CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2)C1 772406 US12419873, Compound 1-15 Tyrosine-protein kinase JAK1 Homo sapiens 20.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772406&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 177858816 523185076 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137629 CC(C)(C#N)CC(=O)N1CC2(CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2)C1 772406 US12419873, Compound 1-15 Tyrosine-protein kinase JAK2 Homo sapiens 208 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772406&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 177858816 523185076 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137630 CC(C)(C#N)CC(=O)N1CC2(CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2)C1 772406 US12419873, Compound 1-15 Tyrosine-protein kinase JAK3 Homo sapiens 9669 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772406&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 177858816 523185076 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137631 O=C(Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1)C1CC1 InChI=1S/C20H24N6O/c21-10-11-25-12-20(13-25)8-6-14(7-9-20)16-2-1-3-17-22-19(24-26(16)17)23-18(27)15-4-5-15/h1-3,14-15H,4-9,11-13H2,(H,23,24,27) QWNOKYCJESLRKP-UHFFFAOYSA-N 50602442 CHEMBL5196106::US11919896, Compound 1-16::US12419873, Compound 1-16 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 581 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602442 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602442&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408512 482613293 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137632 O=C(Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1)C1CC1 InChI=1S/C20H24N6O/c21-10-11-25-12-20(13-25)8-6-14(7-9-20)16-2-1-3-17-22-19(24-26(16)17)23-18(27)15-4-5-15/h1-3,14-15H,4-9,11-13H2,(H,23,24,27) QWNOKYCJESLRKP-UHFFFAOYSA-N 50602442 CHEMBL5196106::US11919896, Compound 1-16::US12419873, Compound 1-16 Tyrosine-protein kinase JAK1 Homo sapiens 114 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602442 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602442&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408512 482613293 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137633 O=C(Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1)C1CC1 InChI=1S/C20H24N6O/c21-10-11-25-12-20(13-25)8-6-14(7-9-20)16-2-1-3-17-22-19(24-26(16)17)23-18(27)15-4-5-15/h1-3,14-15H,4-9,11-13H2,(H,23,24,27) QWNOKYCJESLRKP-UHFFFAOYSA-N 50602442 CHEMBL5196106::US11919896, Compound 1-16::US12419873, Compound 1-16 Tyrosine-protein kinase JAK2 Homo sapiens 1020 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602442 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602442&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408512 482613293 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137634 O=C(Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1)C1CC1 InChI=1S/C20H24N6O/c21-10-11-25-12-20(13-25)8-6-14(7-9-20)16-2-1-3-17-22-19(24-26(16)17)23-18(27)15-4-5-15/h1-3,14-15H,4-9,11-13H2,(H,23,24,27) QWNOKYCJESLRKP-UHFFFAOYSA-N 50602442 CHEMBL5196106::US11919896, Compound 1-16::US12419873, Compound 1-16 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602442 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602442&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408512 482613293 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137635 O=C(Nc1nc2cccc(C3CCC4(CN(CCC#N)C4)CC3)n2n1)C1CC1 InChI=1S/C21H26N6O/c22-11-2-12-26-13-21(14-26)9-7-15(8-10-21)17-3-1-4-18-23-20(25-27(17)18)24-19(28)16-5-6-16/h1,3-4,15-16H,2,5-10,12-14H2,(H,24,25,28) DPYLAAWAFUMTKJ-UHFFFAOYSA-N 50602443 CHEMBL5206970::US11919896, Compound 1-17::US12419873, Compound 1-17 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 371 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602443 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602443&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408518 482613294 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137636 O=C(Nc1nc2cccc(C3CCC4(CN(CCC#N)C4)CC3)n2n1)C1CC1 InChI=1S/C21H26N6O/c22-11-2-12-26-13-21(14-26)9-7-15(8-10-21)17-3-1-4-18-23-20(25-27(17)18)24-19(28)16-5-6-16/h1,3-4,15-16H,2,5-10,12-14H2,(H,24,25,28) DPYLAAWAFUMTKJ-UHFFFAOYSA-N 50602443 CHEMBL5206970::US11919896, Compound 1-17::US12419873, Compound 1-17 Tyrosine-protein kinase JAK1 Homo sapiens 65.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602443 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602443&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408518 482613294 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137637 O=C(Nc1nc2cccc(C3CCC4(CN(CCC#N)C4)CC3)n2n1)C1CC1 InChI=1S/C21H26N6O/c22-11-2-12-26-13-21(14-26)9-7-15(8-10-21)17-3-1-4-18-23-20(25-27(17)18)24-19(28)16-5-6-16/h1,3-4,15-16H,2,5-10,12-14H2,(H,24,25,28) DPYLAAWAFUMTKJ-UHFFFAOYSA-N 50602443 CHEMBL5206970::US11919896, Compound 1-17::US12419873, Compound 1-17 Tyrosine-protein kinase JAK2 Homo sapiens 791 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602443 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602443&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408518 482613294 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137638 O=C(Nc1nc2cccc(C3CCC4(CN(CCC#N)C4)CC3)n2n1)C1CC1 InChI=1S/C21H26N6O/c22-11-2-12-26-13-21(14-26)9-7-15(8-10-21)17-3-1-4-18-23-20(25-27(17)18)24-19(28)16-5-6-16/h1,3-4,15-16H,2,5-10,12-14H2,(H,24,25,28) DPYLAAWAFUMTKJ-UHFFFAOYSA-N 50602443 CHEMBL5206970::US11919896, Compound 1-17::US12419873, Compound 1-17 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602443 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602443&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408518 482613294 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137639 O=C(Nc1nc2cccc(C3CCC4CCN(C(=O)[C@@H]5CC5(F)F)CCC4C3)n2n1)C1CC1 772414 US12419873, Compound 3-7 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 26.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772414&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 177858818 523185084 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137640 O=C(Nc1nc2cccc(C3CCC4CCN(C(=O)[C@@H]5CC5(F)F)CCC4C3)n2n1)C1CC1 772414 US12419873, Compound 3-7 Tyrosine-protein kinase JAK1 Homo sapiens 3.00 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772414&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 177858818 523185084 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137641 O=C(Nc1nc2cccc(C3CCC4CCN(C(=O)[C@@H]5CC5(F)F)CCC4C3)n2n1)C1CC1 772414 US12419873, Compound 3-7 Tyrosine-protein kinase JAK2 Homo sapiens 40.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772414&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 177858818 523185084 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137642 O=C(Nc1nc2cccc(C3CCC4CCN(C(=O)[C@@H]5CC5(F)F)CCC4C3)n2n1)C1CC1 772414 US12419873, Compound 3-7 Tyrosine-protein kinase JAK3 Homo sapiens 1002 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772414&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 177858818 523185084 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137643 N#CCC(=O)N1CCC2CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2CC1 772415 US12419873, Compound 3-8 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 26.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772415 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772415&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 177858819 523185085 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137644 N#CCC(=O)N1CCC2CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2CC1 772415 US12419873, Compound 3-8 Tyrosine-protein kinase JAK1 Homo sapiens 20.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772415 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772415&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 177858819 523185085 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137645 N#CCC(=O)N1CCC2CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2CC1 772415 US12419873, Compound 3-8 Tyrosine-protein kinase JAK2 Homo sapiens 80.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772415 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772415&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 177858819 523185085 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137646 N#CCC(=O)N1CCC2CCC(c3cccc4nc(NC(=O)C5CC5)nn34)CC2CC1 772415 US12419873, Compound 3-8 Tyrosine-protein kinase JAK3 Homo sapiens 2323 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772415 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772415&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 177858819 523185085 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137647 O=C(Nc1nc2cccc(C3CCC4CCN(C(=O)CC(F)(F)F)CCC4C3)n2n1)C1CC1 772416 US12419873, Compound 3-9 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 155 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772416&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 177858820 523185086 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137648 O=C(Nc1nc2cccc(C3CCC4CCN(C(=O)CC(F)(F)F)CCC4C3)n2n1)C1CC1 772416 US12419873, Compound 3-9 Tyrosine-protein kinase JAK1 Homo sapiens 54.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772416&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 177858820 523185086 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137649 O=C(Nc1nc2cccc(C3CCC4CCN(C(=O)CC(F)(F)F)CCC4C3)n2n1)C1CC1 772416 US12419873, Compound 3-9 Tyrosine-protein kinase JAK2 Homo sapiens 294 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772416&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 177858820 523185086 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137650 O=C(Nc1nc2cccc(C3CCC4CCN(C(=O)CC(F)(F)F)CCC4C3)n2n1)C1CC1 772416 US12419873, Compound 3-9 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772416&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 177858820 523185086 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137651 FC1(CCC2(CN(C2)C(=O)CC#N)CC1)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H23FN6O2/c22-21(9-7-20(8-10-21)12-27(13-20)17(29)6-11-23)15-2-1-3-16-24-19(26-28(15)16)25-18(30)14-4-5-14/h1-3,14H,4-10,12-13H2,(H,25,26,30) VMFYDYQBBSPFEJ-UHFFFAOYSA-N 656603 US11919896, Compound 4-6::US12419873, Compound 4-6 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 307 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656603&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408612 496175670 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137652 FC1(CCC2(CN(C2)C(=O)CC#N)CC1)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H23FN6O2/c22-21(9-7-20(8-10-21)12-27(13-20)17(29)6-11-23)15-2-1-3-16-24-19(26-28(15)16)25-18(30)14-4-5-14/h1-3,14H,4-10,12-13H2,(H,25,26,30) VMFYDYQBBSPFEJ-UHFFFAOYSA-N 656603 US11919896, Compound 4-6::US12419873, Compound 4-6 Tyrosine-protein kinase JAK1 Homo sapiens 170 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656603&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408612 496175670 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137653 FC1(CCC2(CN(C2)C(=O)CC#N)CC1)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H23FN6O2/c22-21(9-7-20(8-10-21)12-27(13-20)17(29)6-11-23)15-2-1-3-16-24-19(26-28(15)16)25-18(30)14-4-5-14/h1-3,14H,4-10,12-13H2,(H,25,26,30) VMFYDYQBBSPFEJ-UHFFFAOYSA-N 656603 US11919896, Compound 4-6::US12419873, Compound 4-6 Tyrosine-protein kinase JAK2 Homo sapiens 2008 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656603&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408612 496175670 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137654 FC1(CCC2(CN(C2)C(=O)CC#N)CC1)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H23FN6O2/c22-21(9-7-20(8-10-21)12-27(13-20)17(29)6-11-23)15-2-1-3-16-24-19(26-28(15)16)25-18(30)14-4-5-14/h1-3,14H,4-10,12-13H2,(H,25,26,30) VMFYDYQBBSPFEJ-UHFFFAOYSA-N 656603 US11919896, Compound 4-6::US12419873, Compound 4-6 Tyrosine-protein kinase JAK3 Homo sapiens 8448 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656603&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408612 496175670 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137655 FC(F)(F)CC(=O)N1CC2(C1)CCC(F)(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H23F4N5O2/c22-20(8-6-19(7-9-20)11-29(12-19)16(31)10-21(23,24)25)14-2-1-3-15-26-18(28-30(14)15)27-17(32)13-4-5-13/h1-3,13H,4-12H2,(H,27,28,32) QJILGCDMTILEBZ-UHFFFAOYSA-N 656604 US11919896, Compound 4-7::US12419873, Compound 4-7 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 194 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656604&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408511 496175671 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137656 FC(F)(F)CC(=O)N1CC2(C1)CCC(F)(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H23F4N5O2/c22-20(8-6-19(7-9-20)11-29(12-19)16(31)10-21(23,24)25)14-2-1-3-15-26-18(28-30(14)15)27-17(32)13-4-5-13/h1-3,13H,4-12H2,(H,27,28,32) QJILGCDMTILEBZ-UHFFFAOYSA-N 656604 US11919896, Compound 4-7::US12419873, Compound 4-7 Tyrosine-protein kinase JAK1 Homo sapiens 436 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656604&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408511 496175671 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137657 FC(F)(F)CC(=O)N1CC2(C1)CCC(F)(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H23F4N5O2/c22-20(8-6-19(7-9-20)11-29(12-19)16(31)10-21(23,24)25)14-2-1-3-15-26-18(28-30(14)15)27-17(32)13-4-5-13/h1-3,13H,4-12H2,(H,27,28,32) QJILGCDMTILEBZ-UHFFFAOYSA-N 656604 US11919896, Compound 4-7::US12419873, Compound 4-7 Tyrosine-protein kinase JAK2 Homo sapiens 7685 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656604&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408511 496175671 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137658 FC(F)(F)CC(=O)N1CC2(C1)CCC(F)(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H23F4N5O2/c22-20(8-6-19(7-9-20)11-29(12-19)16(31)10-21(23,24)25)14-2-1-3-15-26-18(28-30(14)15)27-17(32)13-4-5-13/h1-3,13H,4-12H2,(H,27,28,32) QJILGCDMTILEBZ-UHFFFAOYSA-N 656604 US11919896, Compound 4-7::US12419873, Compound 4-7 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656604&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408511 496175671 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137659 FC(F)CC(=O)N1CC2(C1)CCC(F)(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H24F3N5O2/c22-15(23)10-17(30)28-11-20(12-28)6-8-21(24,9-7-20)14-2-1-3-16-25-19(27-29(14)16)26-18(31)13-4-5-13/h1-3,13,15H,4-12H2,(H,26,27,31) PTYXUYMFXZDPRM-UHFFFAOYSA-N 656605 US11919896, Compound 4-8::US12419873, Compound 4-8 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656605&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 156417200 496175672 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137660 FC(F)CC(=O)N1CC2(C1)CCC(F)(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H24F3N5O2/c22-15(23)10-17(30)28-11-20(12-28)6-8-21(24,9-7-20)14-2-1-3-16-25-19(27-29(14)16)26-18(31)13-4-5-13/h1-3,13,15H,4-12H2,(H,26,27,31) PTYXUYMFXZDPRM-UHFFFAOYSA-N 656605 US11919896, Compound 4-8::US12419873, Compound 4-8 Tyrosine-protein kinase JAK1 Homo sapiens 244 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656605&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 156417200 496175672 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137661 FC(F)CC(=O)N1CC2(C1)CCC(F)(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H24F3N5O2/c22-15(23)10-17(30)28-11-20(12-28)6-8-21(24,9-7-20)14-2-1-3-16-25-19(27-29(14)16)26-18(31)13-4-5-13/h1-3,13,15H,4-12H2,(H,26,27,31) PTYXUYMFXZDPRM-UHFFFAOYSA-N 656605 US11919896, Compound 4-8::US12419873, Compound 4-8 Tyrosine-protein kinase JAK2 Homo sapiens 3711 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656605&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 156417200 496175672 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137662 FC(F)CC(=O)N1CC2(C1)CCC(F)(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C21H24F3N5O2/c22-15(23)10-17(30)28-11-20(12-28)6-8-21(24,9-7-20)14-2-1-3-16-25-19(27-29(14)16)26-18(31)13-4-5-13/h1-3,13,15H,4-12H2,(H,26,27,31) PTYXUYMFXZDPRM-UHFFFAOYSA-N 656605 US11919896, Compound 4-8::US12419873, Compound 4-8 Tyrosine-protein kinase JAK3 Homo sapiens 364 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656605&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 156417200 496175672 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137663 O=C(Nc1nc2cccc(C3CCC4(CC3)CCN(C(=O)C3CC3(F)F)C4)n2n1)C1CC1 772420 US12419873, Compound 5-7 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 67.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772420&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408520 523185090 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137664 O=C(Nc1nc2cccc(C3CCC4(CC3)CCN(C(=O)C3CC3(F)F)C4)n2n1)C1CC1 772420 US12419873, Compound 5-7 Tyrosine-protein kinase JAK1 Homo sapiens 31.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772420&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408520 523185090 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137665 O=C(Nc1nc2cccc(C3CCC4(CC3)CCN(C(=O)C3CC3(F)F)C4)n2n1)C1CC1 772420 US12419873, Compound 5-7 Tyrosine-protein kinase JAK2 Homo sapiens 324 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772420&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408520 523185090 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137666 O=C(Nc1nc2cccc(C3CCC4(CC3)CCN(C(=O)C3CC3(F)F)C4)n2n1)C1CC1 772420 US12419873, Compound 5-7 Tyrosine-protein kinase JAK3 Homo sapiens 5759 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772420&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408520 523185090 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137667 O=C(Nc1nc2cccc(C3CCC4(CC3)CCN(C(=O)C3CC3(F)F)C4)n2n1)C1CC1 772421 US12419873, Compound 5-8 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 692 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772421&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408520 523185091 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137668 O=C(Nc1nc2cccc(C3CCC4(CC3)CCN(C(=O)C3CC3(F)F)C4)n2n1)C1CC1 772421 US12419873, Compound 5-8 Tyrosine-protein kinase JAK1 Homo sapiens 75.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772421&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408520 523185091 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137669 O=C(Nc1nc2cccc(C3CCC4(CC3)CCN(C(=O)C3CC3(F)F)C4)n2n1)C1CC1 772421 US12419873, Compound 5-8 Tyrosine-protein kinase JAK2 Homo sapiens 789 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772421&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408520 523185091 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137670 O=C(Nc1nc2cccc(C3CCC4(CC3)CCN(C(=O)C3CC3(F)F)C4)n2n1)C1CC1 772421 US12419873, Compound 5-8 Tyrosine-protein kinase JAK3 Homo sapiens 7349 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772421&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408520 523185091 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137671 O=C(CC#N)N1CC[C@@]2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r,wD:8.8,(3.05,14.56,;3.68,13.16,;5.21,13,;6.11,14.24,;7.02,15.49,;2.77,11.91,;1.23,11.91,;.76,10.45,;2,9.54,;3.25,10.45,;3.34,8.77,;3.34,7.23,;2,6.46,;.67,7.23,;.67,8.77,;2,4.92,;3.34,4.15,;3.34,2.61,;2,1.84,;.67,2.61,;-.8,2.13,;-1.7,3.38,;-3.24,3.38,;-4.01,2.05,;-3.24,.71,;-5.55,2.05,;-6.89,2.82,;-6.89,1.28,;-.8,4.63,;.67,4.15,)| InChI=1S/C22H26N6O2/c23-12-8-19(29)27-13-11-22(14-27)9-6-15(7-10-22)17-2-1-3-18-24-21(26-28(17)18)25-20(30)16-4-5-16/h1-3,15-16H,4-11,13-14H2,(H,25,26,30) JKDKAMXSFCIYIH-UHFFFAOYSA-N 656608 US11919896, Compound 5-9::US12419873, Compound 5-9 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 278 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656608&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408574 496175675 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137672 O=C(CC#N)N1CC[C@@]2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r,wD:8.8,(3.05,14.56,;3.68,13.16,;5.21,13,;6.11,14.24,;7.02,15.49,;2.77,11.91,;1.23,11.91,;.76,10.45,;2,9.54,;3.25,10.45,;3.34,8.77,;3.34,7.23,;2,6.46,;.67,7.23,;.67,8.77,;2,4.92,;3.34,4.15,;3.34,2.61,;2,1.84,;.67,2.61,;-.8,2.13,;-1.7,3.38,;-3.24,3.38,;-4.01,2.05,;-3.24,.71,;-5.55,2.05,;-6.89,2.82,;-6.89,1.28,;-.8,4.63,;.67,4.15,)| InChI=1S/C22H26N6O2/c23-12-8-19(29)27-13-11-22(14-27)9-6-15(7-10-22)17-2-1-3-18-24-21(26-28(17)18)25-20(30)16-4-5-16/h1-3,15-16H,4-11,13-14H2,(H,25,26,30) JKDKAMXSFCIYIH-UHFFFAOYSA-N 656608 US11919896, Compound 5-9::US12419873, Compound 5-9 Tyrosine-protein kinase JAK1 Homo sapiens 68.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656608&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408574 496175675 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137673 O=C(CC#N)N1CC[C@@]2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r,wD:8.8,(3.05,14.56,;3.68,13.16,;5.21,13,;6.11,14.24,;7.02,15.49,;2.77,11.91,;1.23,11.91,;.76,10.45,;2,9.54,;3.25,10.45,;3.34,8.77,;3.34,7.23,;2,6.46,;.67,7.23,;.67,8.77,;2,4.92,;3.34,4.15,;3.34,2.61,;2,1.84,;.67,2.61,;-.8,2.13,;-1.7,3.38,;-3.24,3.38,;-4.01,2.05,;-3.24,.71,;-5.55,2.05,;-6.89,2.82,;-6.89,1.28,;-.8,4.63,;.67,4.15,)| InChI=1S/C22H26N6O2/c23-12-8-19(29)27-13-11-22(14-27)9-6-15(7-10-22)17-2-1-3-18-24-21(26-28(17)18)25-20(30)16-4-5-16/h1-3,15-16H,4-11,13-14H2,(H,25,26,30) JKDKAMXSFCIYIH-UHFFFAOYSA-N 656608 US11919896, Compound 5-9::US12419873, Compound 5-9 Tyrosine-protein kinase JAK2 Homo sapiens 520 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656608&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408574 496175675 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137674 O=C(CC#N)N1CC[C@@]2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 |r,wD:8.8,(3.05,14.56,;3.68,13.16,;5.21,13,;6.11,14.24,;7.02,15.49,;2.77,11.91,;1.23,11.91,;.76,10.45,;2,9.54,;3.25,10.45,;3.34,8.77,;3.34,7.23,;2,6.46,;.67,7.23,;.67,8.77,;2,4.92,;3.34,4.15,;3.34,2.61,;2,1.84,;.67,2.61,;-.8,2.13,;-1.7,3.38,;-3.24,3.38,;-4.01,2.05,;-3.24,.71,;-5.55,2.05,;-6.89,2.82,;-6.89,1.28,;-.8,4.63,;.67,4.15,)| InChI=1S/C22H26N6O2/c23-12-8-19(29)27-13-11-22(14-27)9-6-15(7-10-22)17-2-1-3-18-24-21(26-28(17)18)25-20(30)16-4-5-16/h1-3,15-16H,4-11,13-14H2,(H,25,26,30) JKDKAMXSFCIYIH-UHFFFAOYSA-N 656608 US11919896, Compound 5-9::US12419873, Compound 5-9 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656608&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408574 496175675 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137675 FC(F)(F)CC(=O)N1CCC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C22H26F3N5O2/c23-22(24,25)12-18(31)29-11-10-21(13-29)8-6-14(7-9-21)16-2-1-3-17-26-20(28-30(16)17)27-19(32)15-4-5-15/h1-3,14-15H,4-13H2,(H,27,28,32) DFYLYUZYTTWHMK-UHFFFAOYSA-N 50602432 CHEMBL5195823::US12419873, Compound 5-10 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 1526 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602432&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408523 482613283 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137676 FC(F)(F)CC(=O)N1CCC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C22H26F3N5O2/c23-22(24,25)12-18(31)29-11-10-21(13-29)8-6-14(7-9-21)16-2-1-3-17-26-20(28-30(16)17)27-19(32)15-4-5-15/h1-3,14-15H,4-13H2,(H,27,28,32) DFYLYUZYTTWHMK-UHFFFAOYSA-N 50602432 CHEMBL5195823::US12419873, Compound 5-10 Tyrosine-protein kinase JAK1 Homo sapiens 131 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602432&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408523 482613283 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137677 FC(F)(F)CC(=O)N1CCC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C22H26F3N5O2/c23-22(24,25)12-18(31)29-11-10-21(13-29)8-6-14(7-9-21)16-2-1-3-17-26-20(28-30(16)17)27-19(32)15-4-5-15/h1-3,14-15H,4-13H2,(H,27,28,32) DFYLYUZYTTWHMK-UHFFFAOYSA-N 50602432 CHEMBL5195823::US12419873, Compound 5-10 Tyrosine-protein kinase JAK2 Homo sapiens 2730 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602432&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408523 482613283 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137678 FC(F)(F)CC(=O)N1CCC2(C1)CCC(CC2)c1cccc2nc(NC(=O)C3CC3)nn12 InChI=1S/C22H26F3N5O2/c23-22(24,25)12-18(31)29-11-10-21(13-29)8-6-14(7-9-21)16-2-1-3-17-26-20(28-30(16)17)27-19(32)15-4-5-15/h1-3,14-15H,4-13H2,(H,27,28,32) DFYLYUZYTTWHMK-UHFFFAOYSA-N 50602432 CHEMBL5195823::US12419873, Compound 5-10 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602432&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408523 482613283 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137679 FC1(F)C[C@H]1C(=O)N1CCC2(CC[C@@H](C2)c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |r| InChI=1S/C23H27F2N5O2/c24-23(25)13-16(23)20(32)29-10-8-22(9-11-29)7-6-15(12-22)17-2-1-3-18-26-21(28-30(17)18)27-19(31)14-4-5-14/h1-3,14-16H,4-13H2,(H,27,28,31) QEDMOQUVDLNINX-UHFFFAOYSA-N 50602418 CHEMBL5193147::US11919896, Compound 6-7::US12419873, Compound 6-7 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 829 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602418&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408605 482613269 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137680 FC1(F)C[C@H]1C(=O)N1CCC2(CC[C@@H](C2)c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |r| InChI=1S/C23H27F2N5O2/c24-23(25)13-16(23)20(32)29-10-8-22(9-11-29)7-6-15(12-22)17-2-1-3-18-26-21(28-30(17)18)27-19(31)14-4-5-14/h1-3,14-16H,4-13H2,(H,27,28,31) QEDMOQUVDLNINX-UHFFFAOYSA-N 50602418 CHEMBL5193147::US11919896, Compound 6-7::US12419873, Compound 6-7 Tyrosine-protein kinase JAK1 Homo sapiens 63.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602418&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408605 482613269 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137681 FC1(F)C[C@H]1C(=O)N1CCC2(CC[C@@H](C2)c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |r| InChI=1S/C23H27F2N5O2/c24-23(25)13-16(23)20(32)29-10-8-22(9-11-29)7-6-15(12-22)17-2-1-3-18-26-21(28-30(17)18)27-19(31)14-4-5-14/h1-3,14-16H,4-13H2,(H,27,28,31) QEDMOQUVDLNINX-UHFFFAOYSA-N 50602418 CHEMBL5193147::US11919896, Compound 6-7::US12419873, Compound 6-7 Tyrosine-protein kinase JAK2 Homo sapiens 998 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602418&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408605 482613269 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137682 FC1(F)C[C@H]1C(=O)N1CCC2(CC[C@@H](C2)c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |r| InChI=1S/C23H27F2N5O2/c24-23(25)13-16(23)20(32)29-10-8-22(9-11-29)7-6-15(12-22)17-2-1-3-18-26-21(28-30(17)18)27-19(31)14-4-5-14/h1-3,14-16H,4-13H2,(H,27,28,31) QEDMOQUVDLNINX-UHFFFAOYSA-N 50602418 CHEMBL5193147::US11919896, Compound 6-7::US12419873, Compound 6-7 Tyrosine-protein kinase JAK3 Homo sapiens 9391 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602418&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408605 482613269 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137683 FC1(F)C[C@H]1C(=O)N1CCC2(CC[C@H](C2)c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |r| InChI=1S/C23H27F2N5O2/c24-23(25)13-16(23)20(32)29-10-8-22(9-11-29)7-6-15(12-22)17-2-1-3-18-26-21(28-30(17)18)27-19(31)14-4-5-14/h1-3,14-16H,4-13H2,(H,27,28,31) QEDMOQUVDLNINX-UHFFFAOYSA-N 50602419 CHEMBL5188445::US11919896, Compound 6-8::US12419873, Compound 6-8 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 570 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602419&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408606 482613270 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137684 FC1(F)C[C@H]1C(=O)N1CCC2(CC[C@H](C2)c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |r| InChI=1S/C23H27F2N5O2/c24-23(25)13-16(23)20(32)29-10-8-22(9-11-29)7-6-15(12-22)17-2-1-3-18-26-21(28-30(17)18)27-19(31)14-4-5-14/h1-3,14-16H,4-13H2,(H,27,28,31) QEDMOQUVDLNINX-UHFFFAOYSA-N 50602419 CHEMBL5188445::US11919896, Compound 6-8::US12419873, Compound 6-8 Tyrosine-protein kinase JAK1 Homo sapiens 381 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602419&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408606 482613270 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137685 FC1(F)C[C@H]1C(=O)N1CCC2(CC[C@H](C2)c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |r| InChI=1S/C23H27F2N5O2/c24-23(25)13-16(23)20(32)29-10-8-22(9-11-29)7-6-15(12-22)17-2-1-3-18-26-21(28-30(17)18)27-19(31)14-4-5-14/h1-3,14-16H,4-13H2,(H,27,28,31) QEDMOQUVDLNINX-UHFFFAOYSA-N 50602419 CHEMBL5188445::US11919896, Compound 6-8::US12419873, Compound 6-8 Tyrosine-protein kinase JAK2 Homo sapiens 1924 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602419&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408606 482613270 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137686 FC1(F)C[C@H]1C(=O)N1CCC2(CC[C@H](C2)c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |r| InChI=1S/C23H27F2N5O2/c24-23(25)13-16(23)20(32)29-10-8-22(9-11-29)7-6-15(12-22)17-2-1-3-18-26-21(28-30(17)18)27-19(31)14-4-5-14/h1-3,14-16H,4-13H2,(H,27,28,31) QEDMOQUVDLNINX-UHFFFAOYSA-N 50602419 CHEMBL5188445::US11919896, Compound 6-8::US12419873, Compound 6-8 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602419&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408606 482613270 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137687 FC1(F)C[C@H]1C(=O)N1CC2(C1)CC[C@@H](C2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C21H23F2N5O2/c22-21(23)9-14(21)18(30)27-10-20(11-27)7-6-13(8-20)15-2-1-3-16-24-19(26-28(15)16)25-17(29)12-4-5-12/h1-3,12-14H,4-11H2,(H,25,26,29) SOKYMLHPKZYWKI-UHFFFAOYSA-N 50602420 CHEMBL5197776::US11919896, Compound 7-7::US12419873, Compound 7-7 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 830 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602420&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408532 482613271 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137688 FC1(F)C[C@H]1C(=O)N1CC2(C1)CC[C@@H](C2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C21H23F2N5O2/c22-21(23)9-14(21)18(30)27-10-20(11-27)7-6-13(8-20)15-2-1-3-16-24-19(26-28(15)16)25-17(29)12-4-5-12/h1-3,12-14H,4-11H2,(H,25,26,29) SOKYMLHPKZYWKI-UHFFFAOYSA-N 50602420 CHEMBL5197776::US11919896, Compound 7-7::US12419873, Compound 7-7 Tyrosine-protein kinase JAK1 Homo sapiens 63.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602420&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408532 482613271 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137689 FC1(F)C[C@H]1C(=O)N1CC2(C1)CC[C@@H](C2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C21H23F2N5O2/c22-21(23)9-14(21)18(30)27-10-20(11-27)7-6-13(8-20)15-2-1-3-16-24-19(26-28(15)16)25-17(29)12-4-5-12/h1-3,12-14H,4-11H2,(H,25,26,29) SOKYMLHPKZYWKI-UHFFFAOYSA-N 50602420 CHEMBL5197776::US11919896, Compound 7-7::US12419873, Compound 7-7 Tyrosine-protein kinase JAK2 Homo sapiens 1632 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602420&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408532 482613271 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137690 FC1(F)C[C@H]1C(=O)N1CC2(C1)CC[C@@H](C2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C21H23F2N5O2/c22-21(23)9-14(21)18(30)27-10-20(11-27)7-6-13(8-20)15-2-1-3-16-24-19(26-28(15)16)25-17(29)12-4-5-12/h1-3,12-14H,4-11H2,(H,25,26,29) SOKYMLHPKZYWKI-UHFFFAOYSA-N 50602420 CHEMBL5197776::US11919896, Compound 7-7::US12419873, Compound 7-7 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602420&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408532 482613271 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137691 FC1(F)C[C@H]1C(=O)N1CC2(C1)CC[C@H](C2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C21H23F2N5O2/c22-21(23)9-14(21)18(30)27-10-20(11-27)7-6-13(8-20)15-2-1-3-16-24-19(26-28(15)16)25-17(29)12-4-5-12/h1-3,12-14H,4-11H2,(H,25,26,29) SOKYMLHPKZYWKI-UHFFFAOYSA-N 50602421 CHEMBL5202814::US11919896, Compound 7-8::US12419873, Compound 7-8 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 404 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602421&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408531 482613272 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137692 FC1(F)C[C@H]1C(=O)N1CC2(C1)CC[C@H](C2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C21H23F2N5O2/c22-21(23)9-14(21)18(30)27-10-20(11-27)7-6-13(8-20)15-2-1-3-16-24-19(26-28(15)16)25-17(29)12-4-5-12/h1-3,12-14H,4-11H2,(H,25,26,29) SOKYMLHPKZYWKI-UHFFFAOYSA-N 50602421 CHEMBL5202814::US11919896, Compound 7-8::US12419873, Compound 7-8 Tyrosine-protein kinase JAK1 Homo sapiens 176 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602421&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408531 482613272 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137693 FC1(F)C[C@H]1C(=O)N1CC2(C1)CC[C@H](C2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C21H23F2N5O2/c22-21(23)9-14(21)18(30)27-10-20(11-27)7-6-13(8-20)15-2-1-3-16-24-19(26-28(15)16)25-17(29)12-4-5-12/h1-3,12-14H,4-11H2,(H,25,26,29) SOKYMLHPKZYWKI-UHFFFAOYSA-N 50602421 CHEMBL5202814::US11919896, Compound 7-8::US12419873, Compound 7-8 Tyrosine-protein kinase JAK2 Homo sapiens 2313 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602421&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408531 482613272 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137694 FC1(F)C[C@H]1C(=O)N1CC2(C1)CC[C@H](C2)c1cccc2nc(NC(=O)C3CC3)nn12 |r| InChI=1S/C21H23F2N5O2/c22-21(23)9-14(21)18(30)27-10-20(11-27)7-6-13(8-20)15-2-1-3-16-24-19(26-28(15)16)25-17(29)12-4-5-12/h1-3,12-14H,4-11H2,(H,25,26,29) SOKYMLHPKZYWKI-UHFFFAOYSA-N 50602421 CHEMBL5202814::US11919896, Compound 7-8::US12419873, Compound 7-8 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50602421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50602421&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408531 482613272 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137695 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)[C@H]3CC3(F)F)C4)n2n1)[C@H]1CC1(F)F 772428 US12419873, Compound 8-6 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 127 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772428&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 177858822 523185098 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137696 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)[C@H]3CC3(F)F)C4)n2n1)[C@H]1CC1(F)F 772428 US12419873, Compound 8-6 Tyrosine-protein kinase JAK1 Homo sapiens 14.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772428&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 177858822 523185098 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137697 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)[C@H]3CC3(F)F)C4)n2n1)[C@H]1CC1(F)F 772428 US12419873, Compound 8-6 Tyrosine-protein kinase JAK2 Homo sapiens 110 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772428&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 177858822 523185098 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137698 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)[C@H]3CC3(F)F)C4)n2n1)[C@H]1CC1(F)F 772428 US12419873, Compound 8-6 Tyrosine-protein kinase JAK3 Homo sapiens 7637 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772428&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 177858822 523185098 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137699 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(F)CC4)CC3)n2n1 |r| InChI=1S/C22H24F3N5O2/c23-21(8-9-21)18(32)29-11-20(12-29)6-4-13(5-7-20)15-2-1-3-16-26-19(28-30(15)16)27-17(31)14-10-22(14,24)25/h1-3,13-14H,4-12H2,(H,27,28,31) WFADWUVIQXLFJG-UHFFFAOYSA-N 656615 US11919896, Compound 8-7::US12419873, Compound 8-7 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 1032 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656615&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408533 496175682 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137700 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(F)CC4)CC3)n2n1 |r| InChI=1S/C22H24F3N5O2/c23-21(8-9-21)18(32)29-11-20(12-29)6-4-13(5-7-20)15-2-1-3-16-26-19(28-30(15)16)27-17(31)14-10-22(14,24)25/h1-3,13-14H,4-12H2,(H,27,28,31) WFADWUVIQXLFJG-UHFFFAOYSA-N 656615 US11919896, Compound 8-7::US12419873, Compound 8-7 Tyrosine-protein kinase JAK1 Homo sapiens 63.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656615&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408533 496175682 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137701 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(F)CC4)CC3)n2n1 |r| InChI=1S/C22H24F3N5O2/c23-21(8-9-21)18(32)29-11-20(12-29)6-4-13(5-7-20)15-2-1-3-16-26-19(28-30(15)16)27-17(31)14-10-22(14,24)25/h1-3,13-14H,4-12H2,(H,27,28,31) WFADWUVIQXLFJG-UHFFFAOYSA-N 656615 US11919896, Compound 8-7::US12419873, Compound 8-7 Tyrosine-protein kinase JAK2 Homo sapiens 5463 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656615&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408533 496175682 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137702 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(F)CC4)CC3)n2n1 |r| InChI=1S/C22H24F3N5O2/c23-21(8-9-21)18(32)29-11-20(12-29)6-4-13(5-7-20)15-2-1-3-16-26-19(28-30(15)16)27-17(31)14-10-22(14,24)25/h1-3,13-14H,4-12H2,(H,27,28,31) WFADWUVIQXLFJG-UHFFFAOYSA-N 656615 US11919896, Compound 8-7::US12419873, Compound 8-7 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656615&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408533 496175682 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137703 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)CC#N)CC3)n2n1 |r| InChI=1S/C21H22F2N6O2/c22-21(23)10-14(21)18(31)26-19-25-16-3-1-2-15(29(16)27-19)13-4-7-20(8-5-13)11-28(12-20)17(30)6-9-24/h1-3,13-14H,4-8,10-12H2,(H,26,27,31) KMLAKPXUCUWAFX-UHFFFAOYSA-N 656616 US11919896, Compound 8-8::US12419873, Compound 8-8 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 109 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656616 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656616&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408534 496175683 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137704 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)CC#N)CC3)n2n1 |r| InChI=1S/C21H22F2N6O2/c22-21(23)10-14(21)18(31)26-19-25-16-3-1-2-15(29(16)27-19)13-4-7-20(8-5-13)11-28(12-20)17(30)6-9-24/h1-3,13-14H,4-8,10-12H2,(H,26,27,31) KMLAKPXUCUWAFX-UHFFFAOYSA-N 656616 US11919896, Compound 8-8::US12419873, Compound 8-8 Tyrosine-protein kinase JAK1 Homo sapiens 60.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656616 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656616&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408534 496175683 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137705 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)CC#N)CC3)n2n1 |r| InChI=1S/C21H22F2N6O2/c22-21(23)10-14(21)18(31)26-19-25-16-3-1-2-15(29(16)27-19)13-4-7-20(8-5-13)11-28(12-20)17(30)6-9-24/h1-3,13-14H,4-8,10-12H2,(H,26,27,31) KMLAKPXUCUWAFX-UHFFFAOYSA-N 656616 US11919896, Compound 8-8::US12419873, Compound 8-8 Tyrosine-protein kinase JAK2 Homo sapiens 1376 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656616 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656616&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408534 496175683 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137706 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)CC#N)CC3)n2n1 |r| InChI=1S/C21H22F2N6O2/c22-21(23)10-14(21)18(31)26-19-25-16-3-1-2-15(29(16)27-19)13-4-7-20(8-5-13)11-28(12-20)17(30)6-9-24/h1-3,13-14H,4-8,10-12H2,(H,26,27,31) KMLAKPXUCUWAFX-UHFFFAOYSA-N 656616 US11919896, Compound 8-8::US12419873, Compound 8-8 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656616 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656616&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408534 496175683 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137707 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1 |r| InChI=1S/C20H22F2N6O/c21-20(22)10-14(20)17(29)25-18-24-16-3-1-2-15(28(16)26-18)13-4-6-19(7-5-13)11-27(12-19)9-8-23/h1-3,13-14H,4-7,9-12H2,(H,25,26,29) VQOMSQTWLSZLFR-UHFFFAOYSA-N 656617 US11919896, Compound 8-9::US12419873, Compound 8-9 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 1329 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656617 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656617&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408602 496175684 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137708 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1 |r| InChI=1S/C20H22F2N6O/c21-20(22)10-14(20)17(29)25-18-24-16-3-1-2-15(28(16)26-18)13-4-6-19(7-5-13)11-27(12-19)9-8-23/h1-3,13-14H,4-7,9-12H2,(H,25,26,29) VQOMSQTWLSZLFR-UHFFFAOYSA-N 656617 US11919896, Compound 8-9::US12419873, Compound 8-9 Tyrosine-protein kinase JAK1 Homo sapiens 52.0 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656617 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656617&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408602 496175684 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137709 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1 |r| InChI=1S/C20H22F2N6O/c21-20(22)10-14(20)17(29)25-18-24-16-3-1-2-15(28(16)26-18)13-4-6-19(7-5-13)11-27(12-19)9-8-23/h1-3,13-14H,4-7,9-12H2,(H,25,26,29) VQOMSQTWLSZLFR-UHFFFAOYSA-N 656617 US11919896, Compound 8-9::US12419873, Compound 8-9 Tyrosine-protein kinase JAK2 Homo sapiens 3672 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656617 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656617&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408602 496175684 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137710 FC1(F)C[C@@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1 |r| InChI=1S/C20H22F2N6O/c21-20(22)10-14(20)17(29)25-18-24-16-3-1-2-15(28(16)26-18)13-4-6-19(7-5-13)11-27(12-19)9-8-23/h1-3,13-14H,4-7,9-12H2,(H,25,26,29) VQOMSQTWLSZLFR-UHFFFAOYSA-N 656617 US11919896, Compound 8-9::US12419873, Compound 8-9 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656617 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656617&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408602 496175684 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137711 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)[C@H]3CC3(F)F)C4)n2n1)[C@@H]1CC1(F)F 772432 US12419873, Compound 9-3 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 105 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772432&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 177858823 523185102 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137712 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)[C@H]3CC3(F)F)C4)n2n1)[C@@H]1CC1(F)F 772432 US12419873, Compound 9-3 Tyrosine-protein kinase JAK1 Homo sapiens 7.00 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772432&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 177858823 523185102 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137713 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)[C@H]3CC3(F)F)C4)n2n1)[C@@H]1CC1(F)F 772432 US12419873, Compound 9-3 Tyrosine-protein kinase JAK2 Homo sapiens 292 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772432&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 177858823 523185102 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137714 O=C(Nc1nc2cccc(C3CCC4(CC3)CN(C(=O)[C@H]3CC3(F)F)C4)n2n1)[C@@H]1CC1(F)F 772432 US12419873, Compound 9-3 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772432&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 177858823 523185102 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137715 FC1(F)C[C@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(F)CC4)CC3)n2n1 |r| InChI=1S/C22H24F3N5O2/c23-21(8-9-21)18(32)29-11-20(12-29)6-4-13(5-7-20)15-2-1-3-16-26-19(28-30(15)16)27-17(31)14-10-22(14,24)25/h1-3,13-14H,4-12H2,(H,27,28,31) WFADWUVIQXLFJG-UHFFFAOYSA-N 656619 US11919896, Compound 9-4::US12419873, Compound 9-4 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 1186 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656619 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656619&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408683 496175686 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137716 FC1(F)C[C@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(F)CC4)CC3)n2n1 |r| InChI=1S/C22H24F3N5O2/c23-21(8-9-21)18(32)29-11-20(12-29)6-4-13(5-7-20)15-2-1-3-16-26-19(28-30(15)16)27-17(31)14-10-22(14,24)25/h1-3,13-14H,4-12H2,(H,27,28,31) WFADWUVIQXLFJG-UHFFFAOYSA-N 656619 US11919896, Compound 9-4::US12419873, Compound 9-4 Tyrosine-protein kinase JAK1 Homo sapiens 253 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656619 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656619&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408683 496175686 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137717 FC1(F)C[C@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(F)CC4)CC3)n2n1 |r| InChI=1S/C22H24F3N5O2/c23-21(8-9-21)18(32)29-11-20(12-29)6-4-13(5-7-20)15-2-1-3-16-26-19(28-30(15)16)27-17(31)14-10-22(14,24)25/h1-3,13-14H,4-12H2,(H,27,28,31) WFADWUVIQXLFJG-UHFFFAOYSA-N 656619 US11919896, Compound 9-4::US12419873, Compound 9-4 Tyrosine-protein kinase JAK2 Homo sapiens 982 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656619 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656619&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408683 496175686 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137718 FC1(F)C[C@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(C4)C(=O)C4(F)CC4)CC3)n2n1 |r| InChI=1S/C22H24F3N5O2/c23-21(8-9-21)18(32)29-11-20(12-29)6-4-13(5-7-20)15-2-1-3-16-26-19(28-30(15)16)27-17(31)14-10-22(14,24)25/h1-3,13-14H,4-12H2,(H,27,28,31) WFADWUVIQXLFJG-UHFFFAOYSA-N 656619 US11919896, Compound 9-4::US12419873, Compound 9-4 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656619 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656619&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408683 496175686 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137719 N#CCC(=O)N1CC2(CCC(c3cccc4nc(NC(=O)[C@@H]5CC5(F)F)nn34)CC2)C1 772434 US12419873, Compound 9-5 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 175 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772434&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 156417167 523185104 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137720 N#CCC(=O)N1CC2(CCC(c3cccc4nc(NC(=O)[C@@H]5CC5(F)F)nn34)CC2)C1 772434 US12419873, Compound 9-5 Tyrosine-protein kinase JAK1 Homo sapiens 224 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772434&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 156417167 523185104 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137721 N#CCC(=O)N1CC2(CCC(c3cccc4nc(NC(=O)[C@@H]5CC5(F)F)nn34)CC2)C1 772434 US12419873, Compound 9-5 Tyrosine-protein kinase JAK2 Homo sapiens 624 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772434&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 156417167 523185104 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137722 N#CCC(=O)N1CC2(CCC(c3cccc4nc(NC(=O)[C@@H]5CC5(F)F)nn34)CC2)C1 772434 US12419873, Compound 9-5 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772434&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 156417167 523185104 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137723 FC1(F)C[C@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1 |r| InChI=1S/C20H22F2N6O/c21-20(22)10-14(20)17(29)25-18-24-16-3-1-2-15(28(16)26-18)13-4-6-19(7-5-13)11-27(12-19)9-8-23/h1-3,13-14H,4-7,9-12H2,(H,25,26,29) VQOMSQTWLSZLFR-UHFFFAOYSA-N 656621 US11919896, Compound 9-6::US12419873, Compound 9-6 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 1388 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656621 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656621&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 146408607 496175688 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137724 FC1(F)C[C@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1 |r| InChI=1S/C20H22F2N6O/c21-20(22)10-14(20)17(29)25-18-24-16-3-1-2-15(28(16)26-18)13-4-6-19(7-5-13)11-27(12-19)9-8-23/h1-3,13-14H,4-7,9-12H2,(H,25,26,29) VQOMSQTWLSZLFR-UHFFFAOYSA-N 656621 US11919896, Compound 9-6::US12419873, Compound 9-6 Tyrosine-protein kinase JAK1 Homo sapiens 432 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656621 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656621&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 146408607 496175688 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137725 FC1(F)C[C@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1 |r| InChI=1S/C20H22F2N6O/c21-20(22)10-14(20)17(29)25-18-24-16-3-1-2-15(28(16)26-18)13-4-6-19(7-5-13)11-27(12-19)9-8-23/h1-3,13-14H,4-7,9-12H2,(H,25,26,29) VQOMSQTWLSZLFR-UHFFFAOYSA-N 656621 US11919896, Compound 9-6::US12419873, Compound 9-6 Tyrosine-protein kinase JAK2 Homo sapiens 1174 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656621 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656621&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 146408607 496175688 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137726 FC1(F)C[C@H]1C(=O)Nc1nc2cccc(C3CCC4(CN(CC#N)C4)CC3)n2n1 |r| InChI=1S/C20H22F2N6O/c21-20(22)10-14(20)17(29)25-18-24-16-3-1-2-15(28(16)26-18)13-4-6-19(7-5-13)11-27(12-19)9-8-23/h1-3,13-14H,4-7,9-12H2,(H,25,26,29) VQOMSQTWLSZLFR-UHFFFAOYSA-N 656621 US11919896, Compound 9-6::US12419873, Compound 9-6 Tyrosine-protein kinase JAK3 Homo sapiens >10000 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656621 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656621&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 146408607 496175688 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 1137727 N#CCC(=O)N1CCC2CCC(c3c(F)ccc4nc(NC(=O)C5CC5)nn34)CC2CC1 772436 US12419873, Compound 10-5 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 430 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4916&target=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772436&enzyme=Non-receptor+tyrosine-protein+kinase+TYK2&column=ki&startPg=0&Increment=50&submit=Search 177858824 523185106 1 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC 4PO6,3ZON,5C03,5C01,8TB6,8TB5,3NZ0,7UYU,7UYT,7UYS,7UYR,8S9A,8S99,8S98,7AX4 Non-receptor tyrosine-protein kinase TYK2 TYK2_HUMAN P29597 Q6QB10 Q96CH0 1137728 N#CCC(=O)N1CCC2CCC(c3c(F)ccc4nc(NC(=O)C5CC5)nn34)CC2CC1 772436 US12419873, Compound 10-5 Tyrosine-protein kinase JAK1 Homo sapiens 336 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772436&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 177858824 523185106 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 1137729 N#CCC(=O)N1CCC2CCC(c3c(F)ccc4nc(NC(=O)C5CC5)nn34)CC2CC1 772436 US12419873, Compound 10-5 Tyrosine-protein kinase JAK2 Homo sapiens 812 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772436&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 177858824 523185106 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 1137730 N#CCC(=O)N1CCC2CCC(c3c(F)ccc4nc(NC(=O)C5CC5)nn34)CC2CC1 772436 US12419873, Compound 10-5 Tyrosine-protein kinase JAK3 Homo sapiens 5410 US Patent 10.7270/Q2988CS2 US12419873 Wang, S; Wang, D; Wu, S; Yu, T; Fang, M; Mu, L; Fang, L 9/23/2025 1/6/2026 Zhuhai United Laboratories Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772436&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 177858824 523185106 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7