BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1571416 O=C(O)c1sc2cc(F)ccc2c1-c1c(F)cc2c(c1F)CCCO2 784884 3-(5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-6-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid ::3-(5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-6-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 1 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 110 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784884 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784884&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571417 COc1c(F)cc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784888 6-Fluoro-3-(2,4,6-trifluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid ::6-Fluoro-3-(2,4,6-trifluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 2 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784888&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571418 CC1CCc2c(cc(F)c(-c3c(C(=O)O)sc4cc(F)ccc34)c2F)O1 784889 3-(5,7-Difluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid ::3-(5,7-Difluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 3 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 120 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784889&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571419 O=C(O)c1sc2c(F)c(F)ccc2c1-c1ccccc1 784890 6,7-Difluoro-3-phenyl-1-benzothiophene-2-carboxylic acid ::6,7-Difluoro-3-phenyl-1-benzothiophene-2-carboxylic acid::US12466803, Example 4 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1700 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784890&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571420 O=C([O-])c1sc2cc(F)cc(F)c2c1-c1ccccc1 784891 Ammonium 4,6-difluoro-3-phenyl-1-benzothiophene-2-carboxylate ::Ammonium 4,6-difluoro-3-phenyl-1-benzothiophene-2-carboxylate::US12466803, Example 5 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 3200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784891&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571421 O=C(O)c1sc2cc(Cl)c(F)cc2c1-c1ccccc1 784892 6-Chloro-5-fluoro-3-phenyl-1-benzothiophene-2-carboxylic acid ::6-Chloro-5-fluoro-3-phenyl-1-benzothiophene-2-carboxylic acid::US12466803, Example 6 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 4100 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784892&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571422 O=C(O)c1sc2cc(F)ccc2c1-c1cc(Cl)c(Cl)cc1F 784893 3-(4,5-Dichloro-2-fluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid ::3-(4,5-Dichloro-2-fluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 7 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784893 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784893&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571423 Cc1ncc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784894 3-(3,5-Difluoro-2-methylpyridin-4-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid ::3-(3,5-Difluoro-2-methylpyridin-4-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 8 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 410 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784894&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571424 COc1c(F)c(F)cc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784895 6-Fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid ::6-Fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 9 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784895&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571425 Cc1c(F)c(F)cc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 784896 6-Chloro-3-(2,4,5-trifluoro-3-methylphenyl)-1-benzothiophene-2-carboxylic acid ::6-Chloro-3-(2,4,5-trifluoro-3-methylphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 10 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 22.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784896 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784896&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571426 O=C(O)c1sc2cc(F)c(F)cc2c1-c1ccccc1 784897 5,6-Difluoro-3-phenyl-1-benzothiophene-2-carboxylic acid ::5,6-Difluoro-3-phenyl-1-benzothiophene-2-carboxylic acid::US12466803, Example 11 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2100 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784897 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784897&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571427 COc1c(F)c(F)cc(-c2c(C(=O)[O-])sc3cc(Cl)ccc23)c1F 784898 Ammonium 6-chloro-3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylate ::Ammonium 6-chloro-3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylate::US12466803, Example 12 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 12.1 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784898&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571428 COc1c(F)ccc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 784899 6-Chloro-3-(2,4-difluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid ::6-Chloro-3-(2,4-difluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 13 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 11.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784899&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571429 COc1c(F)cc(Cl)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784900 3-(6-chloro-2,4-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 14 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 4.20 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784900&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571430 COc1c(F)cc(Cl)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784901 3-(6-chloro-2,4-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid, ATROP-1::3-(6-Chloro-2,4-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 15 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784901&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571431 COc1c(F)cc(Cl)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784902 3-(6-chloro-2,4-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid, ATROP-2::3-(6-Chloro-2,4-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 16 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784902&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571432 COc1c(F)c(F)cc(-c2c(C(=O)O)oc3cc(F)ccc23)c1F 784903 6-Fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzofuran-2-carboxylic acid ::6-Fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzofuran-2-carboxylic acid::US12466803, Example 17 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 33.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784903&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571433 COc1c(F)c(F)cc(-c2c(C(=O)O)oc3cc(Cl)ccc23)c1F 784904 6-Chloro-3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzofuran-2-carboxylic acid ::6-Chloro-3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzofuran-2-carboxylic acid::US12466803, Example 18 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 28.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784904&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571434 O=C(O)c1sc2cc(F)ccc2c1-c1ccc(F)c(F)c1F 784905 6-Fluoro-3-(2,3,4-trifluorophenyl)-1-benzothiophene-2-carboxylic acid ::6-Fluoro-3-(2,3,4-trifluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 19 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 190 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784905&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571435 O=C(O)c1sc2cc(Cl)ccc2c1-c1ccc(Cl)c(F)c1 784906 6-Chloro-3-(4-chloro-3-fluorophenyl)-1-benzothiophene-2-carboxylic acid ::6-Chloro-3-(4-chloro-3-fluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 20 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 640 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784906 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784906&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571436 COc1cc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)c1 784907 3-(2,6-Difluoro-4-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid ::3-(2,6-Difluoro-4-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 21 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784907&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571437 O=C(O)c1sc2cc(F)ccc2c1-c1cc(F)c(F)c(O)c1F 784908 6-Fluoro-3-(2,4,5-trifluoro-3-hydroxyphenyl)-1-benzothiophene-2-carboxylic acid ::6-Fluoro-3-(2,4,5-trifluoro-3-hydroxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 22 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1900 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784908&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571438 O=C(O)c1sc2cc(F)ccc2c1-c1cc(F)c(F)cc1F 784909 6-Fluoro-3-(2,4,5-trifluorophenyl)-1-benzothiophene-2-carboxylic acid ::6-Fluoro-3-(2,4,5-trifluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 23 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 34.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784909&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571439 O=C(O)c1sc2cc(F)ccc2c1-c1cc(F)c(F)c(Cl)c1F 784910 3-(3-Chloro-2,4,5-trifluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid ::3-(3-Chloro-2,4,5-trifluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 24 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 7.40 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784910&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571440 COc1cccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1 784911 6-Fluoro-3-(3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid ::6-Fluoro-3-(3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 25 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2500 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784911&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571441 COc1cccc(-c2c(C(=O)O)sc3ccccc23)c1F 784912 3-(2-fluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 26 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784912&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571442 COc1cccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784913 6-fluoro-3-(2-fluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 27 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 800 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784913&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571443 O=C(O)c1sc2cc(F)ccc2c1-c1ccc2c(c1)CCCO2 784914 3-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 28 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1100 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784914&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571444 O=C(O)c1sc2cc(F)ccc2c1-c1ccc(Cl)c(F)c1 784915 3-(4-chloro-3-fluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 29 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2900 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784915&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571445 COc1cccc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 784916 6-chloro-3-(2-fluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 30 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 650 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784916&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571446 O=C(O)c1sc2cc(Cl)ccc2c1-c1ccc2c(c1)CCCO2 784917 6-chloro-3-(3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 31 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1600 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784917&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571447 O=C(O)c1sc2cc(F)ccc2c1-c1ccc2c(c1F)CCCO2 784918 6-fluoro-3-(5-fluoro-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 32 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 650 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784918 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784918&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571448 O=C(O)c1sc2cc(Cl)ccc2c1-c1ccc(F)c(F)c1F 784919 6-chloro-3-(2,3,4-trifluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 33 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 170 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784919&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571449 CCOc1ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)c1F 784920 3-(4-ethoxy-2,3-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 34 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 3100 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784920&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571450 COc1ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)c1F 784921 3-(2,3-difluoro-4-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 35 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2800 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784921&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571451 COc1cc(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)cc1Cl 784922 3-(4-chloro-2-fluoro-5-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 36 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 290 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784922&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571452 O=C(O)c1sc2cc(F)ccc2c1-c1ccc2c(c1)CCCC2 784923 6-fluoro-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 37 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784923&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571453 Cc1c(Cl)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784924 3-(4-chloro-2-fluoro-3-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 38 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 59.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784924&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571454 CCCOc1ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)c1F 784925 3-(2,3-difluoro-4-propoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 39 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 6400 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784925 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784925&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571455 CC1COc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)ccc2C1 784926 6-fluoro-3-(3-methyl-3,4-dihydro-2H-1-benzopyran-7-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 40 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 4000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784926&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571456 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4cc(Cl)ccc34)ccc2O1 784927 6-chloro-3-(2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid, ENANT-1::US12466803, Example 41 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784927 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784927&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571457 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4cc(Cl)ccc34)ccc2O1 784928 6-chloro-3-(2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid, ENANT-2::US12466803, Example 42 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784928 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784928&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571458 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)ccc2O1 784929 6-fluoro-3-(2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid, ENANT-1::US12466803, Example 43 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 7200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784929 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784929&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571459 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)ccc2O1 784930 6-fluoro-3-(2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid, ENANT-2::US12466803, Example 44 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 10000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784930 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784930&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571460 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4ccccc34)ccc2O1 784931 3-(2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid, ENANT-1::US12466803, Example 45 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 5200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784931 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784931&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571461 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4ccccc34)ccc2O1 784932 3-(2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid, ENANT-2::US12466803, Example 46 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2300 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784932 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784932&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571462 O=C(O)c1sc2cc(F)ccc2c1-c1ccccc1 784933 6-fluoro-3-phenyl-1-benzothiophene-2-carboxylic acid::US12466803, Example 47 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 900 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784933&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571463 O=C(O)c1sc2cc(F)ccc2c1-c1c(F)cccc1F 784934 3-(2,6-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 48 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 340 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784934&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571464 COc1c(C#N)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784935 3-(4-cyano-2-fluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 49 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1400 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784935&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571465 CCOc1c(F)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784936 3-(3-ethoxy-2,4-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 50 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 490 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784936&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571466 CCOc1c(Cl)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784937 3-(4-chloro-3-ethoxy-2-fluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 51 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 470 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784937&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571467 COc1c(Cl)cc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784938 3-(4-chloro-2,6-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 52 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 11.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784938&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571468 CCOc1c(F)c(F)cc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784939 6-fluoro-3-[2,4,5-trifluoro-3-(methoxymethyl)phenyl]-1-benzothiophene-2-carboxylic acid::US12466803, Example 53 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 330 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784939&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571469 COc1ccc(-c2c(C(=O)O)sc3cc(F)ccc23)cc1F 784940 6-fluoro-3-(3-fluoro-4-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 54 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 5400 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784940&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571470 COc1ccc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784941 3-(2,6-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 55 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 78.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784941&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571471 CC1CCc2ccc(-c3c(C(=O)O)sc4cc(F)ccc34)cc2O1 784942 6-fluoro-3-(2-methyl-3,4-dihydro-2H-1-benzopyran-7-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 56 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2300 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784942&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571472 C[C@H]1CCc2ccc(-c3c(C(=O)O)sc4cc(F)ccc34)cc2O1 784943 6-fluoro-3-(2-methyl-3,4-dihydro-2H-1-benzopyran-7-yl)-1-benzothiophene-2-carboxylic acid, ENANT-1::US12466803, Example 57 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1900 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784943&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571473 C[C@H]1CCc2ccc(-c3c(C(=O)O)sc4cc(F)ccc34)cc2O1 784944 6-fluoro-3-(2-methyl-3,4-dihydro-2H-1-benzopyran-7-yl)-1-benzothiophene-2-carboxylic acid, ENANT-2::US12466803, Example 58 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 3500 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784944&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571474 O=C(O)c1sc2cc(F)ccc2c1-c1c(F)cc(Cl)cc1F 784945 3-(4-chloro-2,6-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 59 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 260 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784945&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571475 O=C(O)c1sc2cc(F)ccc2c1-c1c(F)cc(F)cc1F 784946 6-fluoro-3-(2,4,6-trifluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 60 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 46.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784946&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571476 COc1ncc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784947 3-(3,5-difluoro-2-methoxypyridin-4-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 61 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 170 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784947&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571477 COc1c(F)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784948 3-(2,4-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 62 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784948&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571478 COc1c(F)cc(F)c(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 784949 6-chloro-3-(2,4,6-trifluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 63 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 7.60 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784949&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571479 O=C(O)c1sc2cc(F)ccc2c1-c1ccc(Cl)cc1F 784950 3-(4-chloro-2-fluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 64 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 620 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784950&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571480 O=C(O)c1sc2cc(F)ccc2c1-c1ccc(Cl)c(F)c1F 784951 3-(4-chloro-2,3-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 65 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 310 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784951&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571481 O=C(O)c1sc2cc(F)ccc2c1-c1ccc2c(c1F)OCCC2 784952 6-fluoro-3-(8-fluoro-3,4-dihydro-2H-1-benzopyran-7-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 66 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 350 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784952&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571482 CC1CCc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)c(F)cc2O1 784953 6-fluoro-3-(7-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 67 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 540 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784953&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571483 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)c(F)cc2O1 784954 6-fluoro-3-(7-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid,::US12466803, Example 68 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 820 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784954&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571484 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)c(F)cc2O1 784955 6-fluoro-3-(7-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid,::US12466803, Example 69 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 430 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784955&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571485 COc1nccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784956 6-fluoro-3-(3-fluoro-2-methoxypyridin-4-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 70 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784956&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571486 CC1CCc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)cc(F)c2O1 784957 6-fluoro-3-(8-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 71 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 760 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784957&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571487 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)cc(F)c2O1 784958 6-fluoro-3-(8-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid,::US12466803, Example 72 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 830 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784958&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571488 C[C@@H]1CCc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)cc(F)c2O1 784959 6-fluoro-3-(8-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid,::US12466803, Example 73 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1300 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784959&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571489 O=C(O)c1sc2cc(Cl)ccc2c1-c1ccccc1 784960 6-chloro-3-phenyl-1-benzothiophene-2-carboxylic acid::US12466803, Example 74 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1300 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784960&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571490 COc1c(C#N)cc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784961 3-(4-cyano-2,6-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 75 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 56.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784961&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571491 CC1CCc2c(ccc(-c3c(C(=O)O)sc4cc(F)ccc34)c2F)O1 784962 6-fluoro-3-(5-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 76 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 430 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784962&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571492 C[C@@H]1CCc2c(ccc(-c3c(C(=O)O)sc4cc(F)ccc34)c2F)O1 784963 6-fluoro-3-(5-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid,::US12466803, Example 77 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 660 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784963&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571493 C[C@@H]1CCc2c(ccc(-c3c(C(=O)O)sc4cc(F)ccc34)c2F)O1 784964 6-fluoro-3-(5-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid,::US12466803, Example 78 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 320 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784964&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571494 COc1c(Cl)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784965 3-(4-chloro-2-fluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 79 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 26.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784965&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571495 CC1CCc2c(cc(F)c(-c3c(C(=O)O)sc4cc(Cl)ccc34)c2F)O1 784966 6-chloro-3-(5,7-difluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 80 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 170 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784966&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571496 CC1CCOc2ccc(-c3c(C(=O)[O-])sc4cc(F)ccc34)cc21 784967 ammonium 6-fluoro-3-(4-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylate::US12466803, Example 81 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1400 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784967&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571497 C[C@H]1CCOc2ccc(-c3c(C(=O)O)sc4cc(F)ccc34)cc21 784968 6-fluoro-3-(4-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid, ENANT-1::US12466803, Example 82 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 770 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784968&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571498 C[C@H]1CCOc2ccc(-c3c(C(=O)O)sc4cc(F)ccc34)cc21 784969 6-fluoro-3-(4-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid, ENANT-2::US12466803, Example 83 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1300 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784969&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571499 C[C@H]1CCc2ccc(-c3c(C(=O)O)sc4cc(F)ccc34)c(F)c2O1 784970 6-fluoro-3-(8-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-7-yl)-1-benzothiophene-2-carboxylic acid,::US12466803, Example 84 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784970&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571500 C[C@H]1CCc2ccc(-c3c(C(=O)O)sc4cc(F)ccc34)c(F)c2O1 784971 6-fluoro-3-(8-fluoro-2-methyl-3,4-dihydro-2H-1-benzopyran-7-yl)-1-benzothiophene-2-carboxylic acid,::US12466803, Example 85 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1700 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784971&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571501 CCc1c(F)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784972 3-(3-ethyl-2,4-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 86 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784972&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571502 Cc1cc2c(cc1-c1c(C(=O)O)sc3cc(F)ccc13)CCCO2 784973 6-fluoro-3-(7-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 87 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2100 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784973&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571503 Cc1c(F)c(F)cc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784974 6-fluoro-3-(2,4,5-trifluoro-3-methylphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 88 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 41.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784974&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571504 COc1c(F)cc(-c2c(C(=O)O)sc3cc(F)ccc23)cc1F 784975 3-(3,5-difluoro-4-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 89 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 12000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784975&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571505 COc1cc(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)cc1F 784976 3-(2,4-difluoro-5-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 90 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 170 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784976&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571506 Cc1cc2c(cc1-c1c(C(=O)O)sc3cc(F)ccc13)OCCC2 784977 6-fluoro-3-(6-methyl-3,4-dihydro-2H-1-benzopyran-7-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 91 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 430 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784977&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571507 CCOc1ccc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1 784978 3-(5-ethoxy-2-fluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 92 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1800 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784978&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571508 CCOc1ccc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784979 3-(3-ethoxy-2,6-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 93 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 930 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784979&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571509 CC(C)Oc1c(F)cc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784980 6-fluoro-3-[2,4,6-trifluoro-3-(propan-2-yloxy)phenyl]-1-benzothiophene-2-carboxylic acid::US12466803, Example 94 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 3900 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784980&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571510 Cc1cc(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)cc1F 784981 3-(2,4-difluoro-5-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 95 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 93.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784981&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571511 CCCOc1ccc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784982 3-(2,6-difluoro-3-propoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 96 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 7600 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784982&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571512 O=C(O)c1sc2cc(F)ccc2c1-c1c(F)ccc(Cl)c1F 784983 3-(3-chloro-2,6-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 97 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 37.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784983&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571513 O=C(O)c1sc2cc(F)ccc2c1-c1ccc2c(c1)CCO2 784984 3-(2,3-dihydro-1-benzofuran-5-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 98 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1300 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784984&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571514 O=C(O)c1sc2cc(F)ccc2c1-c1cc(F)c2c(c1)CCC2 784985 6-fluoro-3-(7-fluoro-2,3-dihydro-1H-inden-5-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 99 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 540 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784985&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571515 O=C(O)c1sc2cc(F)ccc2c1-c1ccc2c(c1)OCC2 784986 3-(2,3-dihydro-1-benzofuran-6-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 100 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2500 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784986&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571516 O=C(O)c1sc2cc(F)ccc2c1-c1ccc2c(c1F)CCC2 784987 6-fluoro-3-(4-fluoro-2,3-dihydro-1H-inden-5-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 101 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 430 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784987&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571517 O=C(O)c1sc2cc(F)ccc2c1-c1c(O)cc(F)cc1F 784988 3-(2,4-difluoro-6-hydroxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 102 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1400 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784988&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571518 Cc1nccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784989 6-fluoro-3-(3-fluoro-2-methylpyridin-4-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 103 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 3100 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784989&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571519 CC1COc2c(ccc(-c3c(C(=O)O)sc4cc(F)ccc34)c2F)C1 784990 6-fluoro-3-(8-fluoro-3-methyl-3,4-dihydro-2H-1-benzopyran-7-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 104 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 3300 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784990&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571520 Cc1cc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)c1 784991 3-(2,6-difluoro-4-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 105 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784991&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571521 Cc1cc(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)cc1Cl 784992 3-(4-chloro-2-fluoro-5-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 106 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 59.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784992&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571522 O=C([O-])c1sc2cc(F)ccc2c1-c1c(F)cncc1F 784993 ammonium 3-(3,5-difluoropyridin-4-yl)-6-fluoro-1-benzothiophene-2-carboxylate::US12466803, Example 107 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1100 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784993&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571523 O=C(O)c1sc2cc(F)ccc2c1-c1cc(Cl)c(F)cc1F 784994 3-(5-chloro-2,4-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 108 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784994&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571524 O=C(O)c1sc2cc(F)ccc2c1-c1cc(F)c(F)c(F)c1F 784995 6-fluoro-3-(2,3,4,5-tetrafluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 109 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784995&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571525 CCc1ncc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784996 3-(2-ethyl-3,5-difluoropyridin-4-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 110 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 370 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784996&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571526 O=C([O-])c1sc2cc(F)ccc2c1-c1cc(F)cc(F)c1Cl 784997 ammonium 3-(2-chloro-3,5-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylate::US12466803, Example 111 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 270 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784997&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571527 CCc1nccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 784998 3-(2-ethyl-3-fluoropyridin-4-yl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 112 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 420 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784998&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571528 O=C(O)c1sc2cc(F)ccc2c1-c1cc(Cl)cc(F)c1Cl 784999 3-(2,5-dichloro-3-fluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 113 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 82.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=784999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=784999&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571529 COc1cc(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)c(F)c1Cl 785000 3-(4-chloro-2,3-difluoro-5-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 114 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 140 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785000&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571530 CC1CCCc2cc(-c3c(C(=O)O)sc4cc(F)ccc34)ccc21 785001 6-fluoro-3-(5-methyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 115 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 21000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785001&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571531 COc1c(F)cc(-c2c(C(=O)[O-])sc3cc(F)ccc23)c(F)c1F 785002 ammonium 6-fluoro-3-(2,3,5-trifluoro-4-methoxyphenyl)-1-benzothiophene-2-carboxylate::US12466803, Example 116 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 360 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785002&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571532 Cc1c(F)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 785003 3-(2,4-difluoro-3-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 117 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785003&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571533 O=C(O)c1sc2cc(F)ccc2c1-c1ccc(F)c2c1CCC2 785004 6-fluoro-3-(7-fluoro-2,3-dihydro-1H-inden-4-yl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 118 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 320 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785004&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571534 COc1cccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1Cl 785005 3-(2-chloro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 119 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 43000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785005&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571535 Cc1c(-c2c(C(=O)O)sc3cc(F)ccc23)ccc(F)c1F 785006 3-(3,4-difluoro-2-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 120 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 250 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785006&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571536 Cc1c(F)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1Cl 785007 3-(2-chloro-4-fluoro-3-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 121 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 490 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785007&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571537 N#Cc1cc(-c2c(C(=O)O)sc3cc(F)ccc23)ccc1C 785008 3-(3-cyano-4-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 122 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 910 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785008&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571538 N#Cc1c(OC)cccc1-c1c(C(=O)O)sc2cc(F)ccc12 785009 3-(2-cyano-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 123 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 24000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785009&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571539 N#Cc1cccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1C 785010 3-(3-cyano-2-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 124 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 6500 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785010&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571540 N#Cc1ccc(C)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1 785011 3-(5-cyano-2-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 125 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 250 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785011&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571541 COc1cccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1C 785012 6-fluoro-3-(3-methoxy-2-methylphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 126 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 15000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785012&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571542 Cc1ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c(F)c1Cl 785013 3-(3-chloro-2-fluoro-4-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 127 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 110 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785013&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571543 O=C(O)c1sc2cc(Cl)ccc2c1-c1c(F)cccc1F 785014 6-chloro-3-(2,6-difluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 128 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 150 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785014&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571544 COc1ccc(F)c(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 785015 6-chloro-3-(2,6-difluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 129 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 74.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785015&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571545 CCOc1c(F)ccc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 785016 6-chloro-3-(3-ethoxy-2,4-difluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 130 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 700 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785016&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571546 Cc1cc(-c2c(C(=O)[O-])sc3cc(Cl)ccc23)c(F)cc1Cl 785017 ammonium 6-chloro-3-(4-chloro-2-fluoro-5-methylphenyl)-1-benzothiophene-2-carboxylate::US12466803, Example 131 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 50.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785017&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571547 O=C([O-])c1sc2cc(Cl)ccc2c1-c1cc(Cl)c(F)cc1F 785018 ammonium 6-chloro-3-(5-chloro-2,4-difluorophenyl)-1-benzothiophene-2-carboxylate::US12466803, Example 132 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785018&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571548 O=C(O)c1sc2cc(Cl)ccc2c1-c1cc(F)c(F)cc1F 785019 6-chloro-3-(2,4,5-trifluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 133 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 47.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785019&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571549 CCc1c(F)c(F)cc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 785020 6-chloro-3-(3-ethyl-2,4,5-trifluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 134 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 13.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785020&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571550 COc1cc(C)c(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 785021 3-(2,6-difluoro-3,5-dimethylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 135 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2600 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785021&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571551 Cc1c(F)c(-c2c(C(=O)[O-])sc3cc(Cl)ccc23)cc(F)c1Cl 785022 ammonium 6-chloro-3-(4-chloro-2,5-difluoro-3-methylphenyl)-1-benzothiophene-2-carboxylate::US12466803, Example 136 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 17.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785022&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571552 Cc1cc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c(F)cc1F 785023 6-chloro-3-(2,4-difluoro-5-methylphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 137 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 33.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785023&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571553 COc1c(Cl)ccc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 785024 6-chloro-3-(4-chloro-2-fluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 138 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 12.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785024&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571554 CCc1c(F)c(F)cc(-c2c(C(=O)[O-])sc3cc(F)ccc23)c1F 785025 ammonium 3-(3-ethyl-2,4,5-trifluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylate::US12466803, Example 139 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 6.70 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785025&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571555 O=C(O)c1sc2cc(F)ccc2c1-c1c(F)c(F)cc(F)c1F 785026 6-fluoro-3-(2,3,5,6-tetrafluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 140 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 33.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785026&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571556 Cc1c(F)ccc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 785027 6-chloro-3-(2,4-difluoro-3-methylphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 141 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785027&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571557 O=C(O)c1sc2cc(Cl)ccc2c1-c1cc(Cl)c(Cl)cc1F 785028 6-chloro-3-(4,5-dichloro-2-fluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 142 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 120 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785028&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571558 CCc1c(F)ccc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 785029 6-chloro-3-(3-ethyl-2,4-difluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 143 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 16.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785029&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571559 COc1cc(OC)c(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 785030 3-(2,6-difluoro-3,5-dimethoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 144 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 19000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785030&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571560 O=C(O)c1sc2cc(Cl)ccc2c1-c1cc(F)cc(F)c1Cl 785031 6-chloro-3-(2-chloro-3,5-difluorophenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 145 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 150 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785031&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571561 Cc1c(Cl)ccc(-c2c(C(=O)O)sc3cc(Cl)ccc23)c1F 785032 6-chloro-3-(4-chloro-2-fluoro-3-methylphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 146 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785032&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571562 O=C(O)c1sc2cc(F)ccc2c1-c1ccc(F)c(C2CC2)c1F 785033 3-(3-cyclopropyl-2,4-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 147 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 17.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785033&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571563 O=C(O)c1sc2cc(F)ccc2c1-c1c(F)cc(F)cc1Cl 785034 3-(2-chloro-4,6-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 148 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 36.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785034&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571564 O=C([O-])c1sc2cc(Cl)ccc2c1-c1cc(F)c(F)c(F)c1F 785035 ammonium 6-chloro-3-(2,3,4,5-tetrafluorophenyl)-1-benzothiophene-2-carboxylate::US12466803, Example 149 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 16.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785035&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571565 COc1ccc(Cl)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 785036 3-(6-chloro-2-fluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 150 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 47.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785036&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571566 O=C(O)c1sc2cc(F)ccc2c1-c1c(F)cc(Cl)cc1Cl 785037 3-(2,4-dichloro-6-fluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 151 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 150 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785037&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571567 Cc1c(F)c(Cl)cc(-c2c(C(=O)O)sc3cc(F)ccc23)c1F 785038 3-(5-chloro-2,4-difluoro-3-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 152 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 220 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785038&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571568 Cc1c(C#N)cc(F)cc1-c1c(C(=O)[O-])sc2cc(F)ccc12 785039 ammonium 3-(3-cyano-5-fluoro-2-methylphenyl)-6-fluoro-1-benzothiophene-2-carboxylate::US12466803, Example 153 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 1100 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785039&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571569 COc1c(F)cc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1Cl 785040 3-(2-chloro-4,6-difluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 154 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 110 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785040&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571570 O=C(O)c1sc2cc(F)ccc2c1-c1cc(F)c(Cl)cc1F 785041 3-(4-chloro-2,5-difluorophenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 155 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 140 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785041&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571571 COc1ccc(F)c(-c2c(C(=O)O)sc3cc(F)ccc23)c1Cl 785042 3-(2-chloro-6-fluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 156 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 42000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785042&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571572 COc1c(F)c(F)cc(-c2c(C(=O)O)sc3ccccc23)c1F 785043 3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid::US12466803, Example 157 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 21.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785043&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571573 O=C(O)c1sc2cc(F)ccc2c1-c1ccc(F)c(C(F)F)c1F 785044 3-[3-(difluoromethyl)-2,4-difluorophenyl]-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 158 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens 2300 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785044&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5 1571574 COc1c(F)ccc(-c2c(C(=O)O)sc3cc(F)ccc23)c1C#N 785045 3-(2-cyano-4-fluoro-3-methoxyphenyl)-6-fluoro-1-benzothiophene-2-carboxylic acid::US12466803, Example 159 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Homo sapiens >35000 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001047&target=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785045&enzyme=%5B3-methyl-2-oxobutanoate+dehydrogenase+%5Blipoamide%5D%5D+kinase%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 1 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI 4H85,4H81,4H7Q,4E02,4E01,4E00,4DZY,3TZ5,3TZ4,3TZ2,3TZ0,8F5S,8F5J,8F5F,7ZPE Branched-chain alpha-ketoacid dehydrogenase kinase BCKD_HUMAN O14874 A8MY43 Q6FGL4 Q96G95 Q96IN5