BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1571575 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785046 N-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide::US12466809, Compound 1 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 6.40 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785046&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571576 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785046 N-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide::US12466809, Compound 1 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 8.10 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785046&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571577 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785047 2-((5-bromo-2-((1-((2-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 2 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 5.10 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785047&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571578 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785047 2-((5-bromo-2-((1-((2-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 2 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 3.80 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785047&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571579 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785048 2-((5-bromo-2-((1-((2-(3-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)propanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 3 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 4.90 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785048&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571580 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785048 2-((5-bromo-2-((1-((2-(3-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)propanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 3 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 4.80 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785048&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571581 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785049 N-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide::US12466809, Compound 4 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 7.30 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785049&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571582 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785049 N-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide::US12466809, Compound 4 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 8.40 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785049&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571583 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785050 2-((5-bromo-2-((1-((2-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 5 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 28.7 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785050&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571584 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785050 2-((5-bromo-2-((1-((2-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 5 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 16.1 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785050&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571585 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785051 2-((5-bromo-2-((1-((2-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 6 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 17.1 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785051&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571586 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785051 2-((5-bromo-2-((1-((2-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 6 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 11.8 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785051&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571587 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785052 2-((5-bromo-2-((1-((2-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 7 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 20.5 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785052&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571588 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785052 2-((5-bromo-2-((1-((2-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 7 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 13.7 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785052&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571589 NC(=O)c1c(F)cccc1Nc1nc(N[C@@H]2CCCN(S(=O)(=O)CCNC(=O)CCCCCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)ncc1Br 785053 2-((5-bromo-2-(((3R)-1-((2-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamido)ethyl)sulfonyl)piperidin-3-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 8 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 347 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785053&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571590 NC(=O)c1c(F)cccc1Nc1nc(N[C@@H]2CCCN(S(=O)(=O)CCNC(=O)CCCCCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)ncc1Br 785053 2-((5-bromo-2-(((3R)-1-((2-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamido)ethyl)sulfonyl)piperidin-3-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 8 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 241 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785053&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571591 Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCC(=O)NCCS(=O)(=O)N2CCC(Nc3ncc(Br)c(Nc4cccc(F)c4C(N)=O)n3)CC2)C(C)(C)C)cc1 785054 (2S,4R)-1-((S)-19-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)-2-(tert-butyl)-4,16-dioxo-7,10,13-trioxa-3,17-diazanonadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide::US12466809, Compound 9 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 7.50 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785054&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571592 Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCC(=O)NCCS(=O)(=O)N2CCC(Nc3ncc(Br)c(Nc4cccc(F)c4C(N)=O)n3)CC2)C(C)(C)C)cc1 785054 (2S,4R)-1-((S)-19-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)-2-(tert-butyl)-4,16-dioxo-7,10,13-trioxa-3,17-diazanonadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide::US12466809, Compound 9 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 4.10 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785054&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571593 Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCC(=O)NCCS(=O)(=O)N2CCC(Nc3ncc(Br)c(Nc4cccc(F)c4C(N)=O)n3)CC2)C(C)(C)C)cc1 785055 N1-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-N6((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)adipamide::US12466809, Compound 10 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 9.10 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785055&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571594 Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCC(=O)NCCS(=O)(=O)N2CCC(Nc3ncc(Br)c(Nc4cccc(F)c4C(N)=O)n3)CC2)C(C)(C)C)cc1 785055 N1-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-N6((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)adipamide::US12466809, Compound 10 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 4.30 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785055&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571595 Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCC(=O)NCCS(=O)(=O)N2CCC(Nc3ncc(Br)c(Nc4cccc(F)c4C(N)=O)n3)CC2)C(C)(C)C)cc1 785056 (2S,4R)-1-((S)-16-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)-2-(tert-butyl)-4,13-dioxo-7,10-dioxa-3,14-diazahexadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide::US12466809, Compound 11 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 6.80 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785056&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571596 Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCC(=O)NCCS(=O)(=O)N2CCC(Nc3ncc(Br)c(Nc4cccc(F)c4C(N)=O)n3)CC2)C(C)(C)C)cc1 785056 (2S,4R)-1-((S)-16-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)-2-(tert-butyl)-4,13-dioxo-7,10-dioxa-3,14-diazahexadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide::US12466809, Compound 11 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 4.80 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785056&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571597 Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCC(=O)NCCS(=O)(=O)N2CCC(Nc3ncc(Br)c(Nc4cccc(F)c4C(N)=O)n3)CC2)C(C)(C)C)cc1 785057 N1-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-N4((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)succinamide::US12466809, Compound 12 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 5.30 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785057&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571598 Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCC(=O)NCCS(=O)(=O)N2CCC(Nc3ncc(Br)c(Nc4cccc(F)c4C(N)=O)n3)CC2)C(C)(C)C)cc1 785057 N1-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-N4((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)succinamide::US12466809, Compound 12 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 3.70 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785057&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571599 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCC(=O)NCCCCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785058 N1-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-N4-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)succinamide::US12466809, Compound 13 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 3.80 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785058&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571600 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCC(=O)NCCCCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785058 N1-(2-((4-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-N4-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)succinamide::US12466809, Compound 13 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 4.30 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785058&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571601 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785059 2-((5-bromo-2-((1-((2-(11-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)undec-10-ynamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 14 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 57.2 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785059&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571602 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785059 2-((5-bromo-2-((1-((2-(11-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)undec-10-ynamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 14 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 31.2 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785059&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571603 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCCCc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785060 2-((5-bromo-2-((1-((2-(11-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)undecanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 15 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 50.0 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785060&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571604 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCCCc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)ncc1Br 785060 2-((5-bromo-2-((1-((2-(11-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)undecanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 15 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 18.2 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785060&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571605 O=C(CCCCCCCCC#Cc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(Nc3cccc4c3OCO4)n2)CC1 785061 N-(2-((4-((4-(benzo[d][1,3]dioxol-4-ylamino)-5-bromopyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-11-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)undec-10-ynamide::US12466809, Compound 16 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens >370 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785061&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571606 O=C(CCCCCCCCC#Cc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(Nc3cccc4c3OCO4)n2)CC1 785061 N-(2-((4-((4-(benzo[d][1,3]dioxol-4-ylamino)-5-bromopyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-11-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)undec-10-ynamide::US12466809, Compound 16 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 4370 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785061&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571607 O=C(CCCCCCCCOc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(Nc3cccc4c3OCO4)n2)CC1 785062 N-(2-((4-((4-(benzo[d][1,3]dioxol-4-ylamino)-5-bromopyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamide::US12466809, Compound 17 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 253 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785062&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571608 O=C(CCCCCCCCOc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(Nc3cccc4c3OCO4)n2)CC1 785062 N-(2-((4-((4-(benzo[d][1,3]dioxol-4-ylamino)-5-bromopyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamide::US12466809, Compound 17 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 924 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785062&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571609 O=C(CCOCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(N3CCCc4ccccc43)n2)CC1 785063 N-(2-((4-((5-bromo-4-(3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide::US12466809, Compound 18 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 23.7 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785063&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571610 O=C(CCOCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(N3CCCc4ccccc43)n2)CC1 785063 N-(2-((4-((5-bromo-4-(3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide::US12466809, Compound 18 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 27.4 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785063&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571611 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC23CC3)ncc1Br 785064 N-(2-((8-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)-5-azaspiro[2.5]octan-5-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide::US12466809, Compound 19 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 116 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785064&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571612 NC(=O)c1c(F)cccc1Nc1nc(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC23CC3)ncc1Br 785064 N-(2-((8-((5-bromo-4-((2-carbamoyl-3-fluorophenyl)amino)pyrimidin-2-yl)amino)-5-azaspiro[2.5]octan-5-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide::US12466809, Compound 19 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 71.3 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785064&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571613 O=C(CCOCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(Nc3cccc4c3C(=O)NC4)n2)CC1 785065 N-(2-((4-((5-bromo-4-((3-oxoisoindolin-4-yl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide::US12466809, Compound 20 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 4.70 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785065&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571614 O=C(CCOCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(Nc3cccc4c3C(=O)NC4)n2)CC1 785065 N-(2-((4-((5-bromo-4-((3-oxoisoindolin-4-yl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide::US12466809, Compound 20 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 5.80 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785065&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571615 O=C(CCCCCCCCOc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(Nc3cccc4c3C(=O)NC4)n2)CC1 785066 N-(2-((4-((5-bromo-4-((3-oxoisoindolin-4-yl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamide::US12466809, Compound 21 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 10.5 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785066&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571616 O=C(CCCCCCCCOc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCS(=O)(=O)N1CCC(Nc2ncc(Br)c(Nc3cccc4c3C(=O)NC4)n2)CC1 785066 N-(2-((4-((5-bromo-4-((3-oxoisoindolin-4-yl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)ethyl)-9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamide::US12466809, Compound 21 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 7.60 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785066&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571617 Cn1ncc(Nc2nc(NC3CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)ncc2Br)c1C(N)=O 785067 4-((5-bromo-2-((1-((2-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-1-methyl-1H-pyrazole-5-carboxamide::US12466809, Compound 22 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 5.70 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785067&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571618 Cn1ncc(Nc2nc(NC3CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)ncc2Br)c1C(N)=O 785067 4-((5-bromo-2-((1-((2-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)nonanamido)ethyl)sulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-1-methyl-1H-pyrazole-5-carboxamide::US12466809, Compound 22 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 5.70 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785067&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571619 NC(=O)c1c(F)cccc1Nc1nc(Nc2ccc(S(=O)(=O)NCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)cc2)ncc1Br 785068 2-((5-bromo-2-((4-(N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)sulfamoyl)phenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 23 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 10.9 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785068&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571620 NC(=O)c1c(F)cccc1Nc1nc(Nc2ccc(S(=O)(=O)NCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)cc2)ncc1Br 785068 2-((5-bromo-2-((4-(N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)sulfamoyl)phenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 23 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 7.00 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785068&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571621 Cc1cc(ccc1Nc1ncc(Br)c(Nc2cccc(F)c2C(N)=O)n1)S(=O)(=O)NCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 InChI=1S/C41H45BrFN9O11S/c1-24-22-25(8-9-29(24)49-41-46-23-27(42)37(51-41)48-31-7-3-5-28(43)35(31)36(44)54)64(58,59)47-13-15-61-17-19-63-21-20-62-18-16-60-14-12-45-30-6-2-4-26-34(30)40(57)52(39(26)56)32-10-11-33(53)50-38(32)55/h2-9,22-23,32,45,47H,10-21H2,1H3,(H2,44,54)(H,50,53,55)(H2,46,48,49,51) ZOJWMCDSTRTTOW-UHFFFAOYSA-N 50622456 CHEMBL5409959::US12466809, Compound 24 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 6.50 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622456&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571622 Cc1cc(ccc1Nc1ncc(Br)c(Nc2cccc(F)c2C(N)=O)n1)S(=O)(=O)NCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 InChI=1S/C41H45BrFN9O11S/c1-24-22-25(8-9-29(24)49-41-46-23-27(42)37(51-41)48-31-7-3-5-28(43)35(31)36(44)54)64(58,59)47-13-15-61-17-19-63-21-20-62-18-16-60-14-12-45-30-6-2-4-26-34(30)40(57)52(39(26)56)32-10-11-33(53)50-38(32)55/h2-9,22-23,32,45,47H,10-21H2,1H3,(H2,44,54)(H,50,53,55)(H2,46,48,49,51) ZOJWMCDSTRTTOW-UHFFFAOYSA-N 50622456 CHEMBL5409959::US12466809, Compound 24 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 6.80 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622456&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571623 Cc1cc(Nc2ncc(Br)c(Nc3cccc(F)c3C(N)=O)n2)ccc1S(=O)(=O)NCCOCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O 785070 2-((5-bromo-2-((4-(N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)sulfamoyl)-3-methylphenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 25 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 8.10 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785070&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571624 Cc1cc(Nc2ncc(Br)c(Nc3cccc(F)c3C(N)=O)n2)ccc1S(=O)(=O)NCCOCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O 785070 2-((5-bromo-2-((4-(N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)sulfamoyl)-3-methylphenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 25 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 7.10 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785070&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571625 Cc1cc(S(=O)(=O)NCCOCCOCCOCCOCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1Nc1ncc(Br)c(Nc2cccc(F)c2C(N)=O)n1 785071 2-((5-bromo-2-((4-(N-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)sulfamoyl)-2-methylphenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 46 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 1.70 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785071&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571626 Cc1cc(S(=O)(=O)NCCOCCOCCOCCOCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1Nc1ncc(Br)c(Nc2cccc(F)c2C(N)=O)n1 785071 2-((5-bromo-2-((4-(N-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)sulfamoyl)-2-methylphenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 46 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 1.40 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785071&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571627 Cc1cc(S(=O)(=O)NCCCCCCCCCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1Nc1ncc(Br)c(Nc2cccc(F)c2C(N)=O)n1 785072 2-((5-bromo-2-((4-(N-(10-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)decyl)sulfamoyl)-2-methylphenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 47 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 19.4 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785072&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571628 Cc1cc(S(=O)(=O)NCCCCCCCCCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1Nc1ncc(Br)c(Nc2cccc(F)c2C(N)=O)n1 785072 2-((5-bromo-2-((4-(N-(10-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)decyl)sulfamoyl)-2-methylphenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 47 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 18.2 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785072&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4 1571629 Cc1cc(S(=O)(=O)NCCCCN2CCN(C(=O)COc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ccc1Nc1ncc(Br)c(Nc2cccc(F)c2C(N)=O)n1 785073 2-((5-bromo-2-((4-(N-(4-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)butyl)sulfamoyl)-2-methylphenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 48 Cyclin-A2/Cyclin-dependent kinase 2 Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=97&target=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785073&enzyme=Cyclin-A2%2FCyclin-dependent+kinase+2&column=ki&startPg=0&Increment=50&submit=Search 2 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 9OB6,9OB5,9OB4,9OB3,9OB2,9FR2,9BJC,8B54,7QHL,7B7S,7ACK,6RIJ,6JGM,6INL,6GVA,5LMK,5L2W,3DOG,3DDQ,3DDP,2G9X,2CCI,2CCH,1QMZ,1P5E,1GY3,9QJJ,9QCX,9QCV,9NYR,9NYQ,9I9K,9I9J,9GP3,9GOP,9D0X,9D0W,9D0V,9D0U,8VQ4,8VQ3,8ROZ,8OY2,8OR4,8OR0,8FP5,8FP0,8FOW,8CUR,7VDU,7UXK,7UXI,7SA0,7S9X,7S85,7S84,7S7A,7S4T,7RXO,7RWE,7RA5,7NVQ,7M2F,7KJS,7B5R,7B5L,6P3W,6ATH,5K4J,5JQ8,5JQ5,5IF1,5IEY,5IEX,5IEV,5FP6,5FP5,5D1J,5ANO,5ANK,5ANJ,5ANI,5ANG,5ANE,5AND,5A14,4RJ3,4NJ3,4LYN,4KD1,4II5,4FX3,4FKW,4FKV,4FKU,4FKT,4FKS,4FKR,4FKQ,4FKP,4FKO,4FKL,4FKJ,4FKI,4FKG,4EK8,4EK6,4EK5,4EK4,4EK3,4D1Z,4D1X,4BZD,4BGH,4BCP,4BCO,4BCN,4BCK,4ACM,3WBL,3UNK,3UNJ,3ULI,3TNW,3TIZ,3TIY,3TI1,3SW7,3SW4,3S2P,3PJ8,3NS9,3MY5,3LFS,3LFQ,3LFN,3LE6,3IGG,3IG7,3FZ1,3F5X,3EZV,3EZR,3EOC,3EJ1,3EID,3BHV,3BHU,3BHT,2XNB,2XMY,2X1N,2WHB,2WFY,2WEV,2W1H,2W17,2W06,2W05,2VV9,2VU3,2VTT,2VTS,2VTR,2VTQ,2VTP,2VTO,2VTN,2VTM,2VTL,2VTJ,2VTI,2VTH,2VTA,2V22,2V0D,2UZO,2UZN,2UZL,2UZE,2UZD,2UZB,2UUE,2R64,2R3R,2R3Q,2R3P,2R3O,2R3N,2R3M,2R3L,2R3K,2R3J,2R3I,2R3H,2R3G,2R3F,2J9M,2I40,2FVD,2EXM,2DUV,2CLX,2CJM,2C6T,2C6O,2C6M,2C6L,2C6K,2C6I,2C69,2C68,2C5Y,2C5X,2C5V,2C5O,2C5N,2BTS,2BTR,2BHH,2BHE,2B55,2B54,2B53,2B52,2A4L,2A0C,1YKR,1Y91,1Y8Y,1WCC,1W8C,1W0X,1VYZ,1V1K,1URW,1URC,1R78,1PYE,1PXP,1PXO,1PXN,1PXM,1PXL,1PXK,1PXJ,1PXI,1PW2,1PF8,1P2A,1OL2,1OL1,1OKW,1OKV,1OIR,1OIQ,1KE9,1KE8,1KE7,1KE6,1KE5,1JVP,1JSV,1JSU,1JST,1HCL,1HCK,1H0W,1H0V,1H08,1H07,1H01,1H00,1GZ8,1GIH,1G5S,1FVV,1FVT,1FQ1,1FIN,1F5Q,1E1X,1E1V,1DM2,1DI8,1CKP,1BUH,1B39,1B38,1AQ1,8ERN,8ERD,7RWF,6OQI,5UQ3,5UQ2,5UQ1,4BCQ,4BCM,9JJ5,9GNO,8YQE,8YPW,7ZPC,7UG1,7MKX,6Q4K,6Q4J,6Q4H,6Q4F,6Q4E,6Q4D,6Q4C,6Q4B,6Q4A,6Q49,6Q48,6Q3F,6Q3C,6Q3B,6GUK,6GUH,5OSJ,5OO0,5NEV,5MHQ,5CYI,4GCJ,4EZ7,4EZ3,4ERW,4CFX,4CFW,4CFM,3SQQ,3S1H,3S0O,3S00,3RZB,3RPY,3RPV,3RPR,3RPO,3ROY,3RNI,3RMF,3RM7,3RM6,3RKB,3RK9,3RK7,3RK5,3RJC,3RAL,3RAK,3RAI,3RAH,3R9O,3R9N,3R9H,3R9D,3R8Z,3R8V,3R8U,3R8P,3R8M,3R8L,3R83,3R7Y,3R7V,3R7U,3R7I,3R7E,3R73,3R71,3R6X,3R28,3R1Y,3R1S,3R1Q,3QZI,3QZH,3QZG,3QZF,3QXP,3QXO,3QX4,3QX2,3QWK,3QWJ,3QU0,3QTZ,3QTX,3QTW,3QTU,3QTS,3QTR,3QTQ,3QRU,3QRT,3QQL,3QQK,3QQJ,3QQH,3QQG,3QQF,3QL8,3PY1,3PY0,3PXZ,3PXY,3PXR,3PXQ,3PXF,2WMB,2WMA,1H28,1H27,1H26,1H25,1H24,1H1S,1H1R,1H1Q Cyclin-dependent kinase 2 CDK2_HUMAN P24941 A8K7C6 O75100 MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL 8BZO,8BYA,7B5R,7B5L,6Q6G,6Q6H,4BCP,4BCM,4BCK,7MKX,2X1N,4CFX,3EOC,3EJ1,3EID,2WHB,2WFY,2WEV,2I40,2CCH,2C5O,1URC,1OL2,1OL1,1OKW,1OKV,1JSU,1FVV,1FIN,5NEV,5CYI,2IW9,2IW8,2IW6,1OIY,1OIU,1OI9,1OGU,2WMB,2WMA,2V22,2UUE,2C5X,2C5V,2C5N,1QMZ,1H28,1H27,1H26,1H25,1H24,1E9H,9GLA,8B54,7QHL,7B7S,7ACK,6RIJ,6GVA,5LMK,4FX3,4EOS,4EOR,4EOQ,4EOP,4EOO,4EON,4EOM,4EOL,4EOK,4EOJ,4EOI,4CFW,4CFN,4CFM,2UZL,2UZE,2UZD,2UZB,2CJM,2CCI,2C6T,1PKD,1P5E,1JST,1H1S,1H1R,1H1Q,1H1P,1GY3,6P3W,3F5X,4CFU,8ROZ,9ETP,9ETB,9ETA,9ET9,9ET8,9ET7,9ET6,9ET5,9ET4,9ET3,9ET2,9ET1,9ET0,9ESZ,9ESY,9ESX,9ESW,9ESV,9ESU,9ESS,9ESR,9ESQ,9ESP,9ESO,9ESN,9ESL,9ESK,9ESJ,6GUF,6GUC,6GUB Cyclin-A2 CCNA2_HUMAN P20248 A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 1571630 Cc1cc(S(=O)(=O)NCCCCN2CCN(C(=O)COc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)ccc1Nc1ncc(Br)c(Nc2cccc(F)c2C(N)=O)n1 785073 2-((5-bromo-2-((4-(N-(4-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetyl)piperazin-1-yl)butyl)sulfamoyl)-2-methylphenyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide::US12466809, Compound 48 Cyclin-dependent kinase 5 activator 1 [99-307] Homo sapiens 2.90 Curated from the literature by BindingDB n/a 11/11/2025 3/2/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=105&target=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785073&enzyme=Cyclin-dependent+kinase+5+activator+1+%5B99-307%5D&column=ki&startPg=0&Increment=50&submit=Search 2 AQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 7VDS,7VDR,7VDQ,7VDP,1UNL,1UNH,1UNG,3O0G,1H4L Cyclin-dependent kinase 5 activator 1 CD5R1_HUMAN Q15078 E1P664 Q5U0G3 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 4AU8,7VDS,7VDR,7VDQ,7VDP Cyclin-dependent kinase 5 CDK5_HUMAN Q00535 A1XKG3 Cyclin-dependent kinase 5 A0A090N7W4_HUMAN A0A090N7W4