BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1572448 COC(=O)c1cc(Br)cnc1N1CCC(N[C@@H]2CCCC[C@H]2O)CC1 785456 US20250346584, Compound 1 Kappa-type opioid receptor Homo sapiens 231 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785456&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572449 CCOC(=O)c1c(Cl)cc(C)nc1N1CCC(N[C@@H]2CCCC[C@H]2O)CC1 785457 US20250346584, Compound 2 Kappa-type opioid receptor Homo sapiens 4500 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785457 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785457&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572450 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCC1O |w:17.19,22.25| InChI=1S/C17H24BrN3O3/c1-24-17(23)13-9-11(18)10-19-16(13)21-7-5-12(6-8-21)20-14-3-2-4-15(14)22/h9-10,12,14-15,20,22H,2-8H2,1H3 SEPWGFMMNBAELE-UHFFFAOYSA-N 154057 US9682966, 3::US10118915, Compound 3::US20250346584, Compound 3 Kappa-type opioid receptor Homo sapiens 287 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154057&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296926 253651164 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572451 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NCCO InChI=1S/C14H20BrN3O3/c1-21-14(20)12-8-10(15)9-17-13(12)18-5-2-11(3-6-18)16-4-7-19/h8-9,11,16,19H,2-7H2,1H3 PRUVRNXXJNJMFP-UHFFFAOYSA-N 154336 US9682966, 6::US10118915, Compound 6::US20250346584, Compound 6 Kappa-type opioid receptor Homo sapiens 9200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154336 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154336&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156204 253651441 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572452 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C18H26BrN3O2/c1-24-18(23)16-11-13(19)12-20-17(16)22-9-7-15(8-10-22)21-14-5-3-2-4-6-14/h11-12,14-15,21H,2-10H2,1H3 BIVVISPEOMTPMF-UHFFFAOYSA-N 154489 US9682966, 7::US10118915, Compound 7::US20250346584, Compound 7 Kappa-type opioid receptor Homo sapiens 133 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=154489 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=154489&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156211 253651591 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572453 CCOC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCC[C@@H]1O |r| InChI=1S/C19H28BrN3O3/c1-2-26-19(25)15-11-13(20)12-21-18(15)23-9-7-14(8-10-23)22-16-5-3-4-6-17(16)24/h11-12,14,16-17,22,24H,2-10H2,1H3 DBMQMYAHKFJUAZ-UHFFFAOYSA-N 155002 US9682966, 8::US10118915, Compound 8::US20250346584, Compound 8 Kappa-type opioid receptor Homo sapiens 579 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155002&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263600 253652084 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572454 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCC(O)C1 InChI=1S/C18H26BrN3O3/c1-25-18(24)16-9-12(19)11-20-17(16)22-7-5-13(6-8-22)21-14-3-2-4-15(23)10-14/h9,11,13-15,21,23H,2-8,10H2,1H3 JBHZRUGDBNFWSA-UHFFFAOYSA-N 155022 US9682966, 10::US10118915, Compound 10::US20250346584, Compound 10 Kappa-type opioid receptor Homo sapiens 652 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155022&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156206 253652104 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572455 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1C2CC3CC(C2)CC1C3 |TLB:20:21:25:18.19.24,17:18:25:21.22.27,THB:20:19:25:21.22.27,22:21:18:25.23.24,22:23:18:21.20.27,(3.04,-1.05,;1.93,-2.11,;2.29,-3.61,;3.77,-4.04,;1.17,-4.67,;1.54,-6.17,;.42,-7.23,;.79,-8.73,;-1.05,-6.8,;-1.42,-5.3,;-.3,-4.24,;-.67,-2.74,;-2.14,-2.31,;-2.51,-.81,;-1.39,.25,;.08,-.18,;.45,-1.68,;-1.76,1.75,;-.64,2.81,;.2,4.29,;.2,5.68,;1.57,6.38,;2.94,5.68,;2.94,4.29,;1.57,3.59,;2.1,2.81,;.73,3.51,;.73,4.9,)| 155024 US9682966, 11::US10118915, Compound 11::US20250346584, Compound 11 Kappa-type opioid receptor Homo sapiens 2800 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155024&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73297101 253652106 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572456 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCC[C@H]1O |r| InChI=1S/C17H24BrN3O3/c1-24-17(23)13-9-11(18)10-19-16(13)21-7-5-12(6-8-21)20-14-3-2-4-15(14)22/h9-10,12,14-15,20,22H,2-8H2,1H3 SEPWGFMMNBAELE-UHFFFAOYSA-N 155091 US9682966, 12::US10118915, Compound 12::US20250346584, Compound 12 Kappa-type opioid receptor Homo sapiens 765 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155091&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263602 253652172 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572457 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C17H24BrN3O3/c1-23-17(22)15-10-12(18)11-19-16(15)21-6-2-13(3-7-21)20-14-4-8-24-9-5-14/h10-11,13-14,20H,2-9H2,1H3 AEJRXZAXGRDVEN-UHFFFAOYSA-N 155095 US9682966, 13::US10118915, Compound 13::US20250346584, Compound 13 Kappa-type opioid receptor Homo sapiens 621 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155095&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156238 253652176 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572458 COC(=O)c1cc(Br)cnc1N1CCC(C1)NC1CCCCC1 InChI=1S/C17H24BrN3O2/c1-23-17(22)15-9-12(18)10-19-16(15)21-8-7-14(11-21)20-13-5-3-2-4-6-13/h9-10,13-14,20H,2-8,11H2,1H3 JOYRSQQCLWAALH-UHFFFAOYSA-N 155103 US9682966, 14::US10118915, Compound 14::US20250346584, Compound 14 Kappa-type opioid receptor Homo sapiens 185 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155103&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156221 253652184 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572459 COC(=O)c1cc(Br)cnc1N1C2CCC1CC(C2)NC1CCCCC1 InChI=1S/C20H28BrN3O2/c1-26-20(25)18-9-13(21)12-22-19(18)24-16-7-8-17(24)11-15(10-16)23-14-5-3-2-4-6-14/h9,12,14-17,23H,2-8,10-11H2,1H3 VXYISRVMMGSQTD-UHFFFAOYSA-N 155113 US9682966, 15::US10118915, Compound 15::US20250346584, Compound 15 Kappa-type opioid receptor Homo sapiens 7700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155113&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263613 253652194 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572460 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCC(C)CC1 |(-2.85,-.13,;-1.51,.64,;-1.51,2.18,;-2.85,2.95,;-.18,2.95,;-.18,4.49,;1.15,5.26,;1.15,6.8,;2.49,4.49,;2.49,2.95,;1.15,2.18,;1.15,.64,;2.49,-.13,;2.49,-1.67,;1.15,-2.44,;-.18,-1.67,;-.18,-.13,;1.15,-3.98,;-.18,-4.75,;-.18,-6.29,;-1.51,-7.06,;-2.85,-6.29,;-4.18,-7.06,;-2.85,-4.75,;-1.51,-3.98,)| InChI=1S/C19H28BrN3O2/c1-13-3-5-15(6-4-13)22-16-7-9-23(10-8-16)18-17(19(24)25-2)11-14(20)12-21-18/h11-13,15-16,22H,3-10H2,1-2H3 DRRFYFNTLGUXFK-UHFFFAOYSA-N 155154 US9682966, 16::US10118915, Compound 16::US20250346584, Compound 16 Kappa-type opioid receptor Homo sapiens 536 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155154&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156240 355041317 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572461 COC(=O)c1cc(Br)cnc1N1CCC(CC1)N[C@H](C)C1CCCCC1 |r| InChI=1S/C20H30BrN3O2/c1-14(15-6-4-3-5-7-15)23-17-8-10-24(11-9-17)19-18(20(25)26-2)12-16(21)13-22-19/h12-15,17,23H,3-11H2,1-2H3 WISMZBLXRNLYNT-UHFFFAOYSA-N 155264 US9682966, 17::US10118915, Compound 17::US20250346584, Compound 17 Kappa-type opioid receptor Homo sapiens 6800 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155264 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155264&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156219 355041318 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572462 COC(=O)c1cc(Br)cnc1N1CCC(CC1)N1CCCCC1 InChI=1S/C17H24BrN3O2/c1-23-17(22)15-11-13(18)12-19-16(15)21-9-5-14(6-10-21)20-7-3-2-4-8-20/h11-12,14H,2-10H2,1H3 TZGNONSEVVQPLZ-UHFFFAOYSA-N 155265 US9682966, 18::US10118915, Compound 18::US20250346584, Compound 18 Kappa-type opioid receptor Homo sapiens 2100 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155265 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155265&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73297102 355041319 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572463 COC(=O)c1cc(Br)cnc1N1CCC(CC1)N(C)C1CCCCC1 InChI=1S/C19H28BrN3O2/c1-22(15-6-4-3-5-7-15)16-8-10-23(11-9-16)18-17(19(24)25-2)12-14(20)13-21-18/h12-13,15-16H,3-11H2,1-2H3 HGYWYIFRODIYFX-UHFFFAOYSA-N 155266 US9682966, 19::US10118915, Compound 19::US20250346584, Compound 19 Kappa-type opioid receptor Homo sapiens 2700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155266 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155266&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156243 355041320 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572464 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCCCC1 InChI=1S/C19H28BrN3O2/c1-25-19(24)17-12-14(20)13-21-18(17)23-10-8-16(9-11-23)22-15-6-4-2-3-5-7-15/h12-13,15-16,22H,2-11H2,1H3 WBAILAAMWHNMAW-UHFFFAOYSA-N 155267 US9682966, 20::US10118915, Compound 20::US20250346584, Compound 20 Kappa-type opioid receptor Homo sapiens 110 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155267 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155267&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156237 355041321 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572465 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCCCCC1 InChI=1S/C20H30BrN3O2/c1-26-20(25)18-13-15(21)14-22-19(18)24-11-9-17(10-12-24)23-16-7-5-3-2-4-6-8-16/h13-14,16-17,23H,2-12H2,1H3 ZLGSZEJQNCXACK-UHFFFAOYSA-N 155268 US9682966, 21::US10118915, Compound 21::US20250346584, Compound 21 Kappa-type opioid receptor Homo sapiens 317 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155268&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73294682 355041322 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572466 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CC2CCC1(C)C2(C)C InChI=1S/C22H32BrN3O2/c1-21(2)14-5-8-22(21,3)18(11-14)25-16-6-9-26(10-7-16)19-17(20(27)28-4)12-15(23)13-24-19/h12-14,16,18,25H,5-11H2,1-4H3 VNDQMSDVXZAQME-UHFFFAOYSA-N 155269 US9682966, 22::US10118915, Compound 22::US20250346584, Compound 22 Kappa-type opioid receptor Homo sapiens 10000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155269 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155269&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263608 355041323 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572467 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCC(C)C1C InChI=1S/C20H30BrN3O2/c1-13-5-4-6-18(14(13)2)23-16-7-9-24(10-8-16)19-17(20(25)26-3)11-15(21)12-22-19/h11-14,16,18,23H,4-10H2,1-3H3 CPBUNDVQUHTWJB-UHFFFAOYSA-N 155270 US9682966, 23::US10118915, Compound 23::US20250346584, Compound 23 Kappa-type opioid receptor Homo sapiens 854 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155270&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73294683 355041324 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572468 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCC1 InChI=1S/C17H24BrN3O2/c1-23-17(22)15-10-12(18)11-19-16(15)21-8-6-14(7-9-21)20-13-4-2-3-5-13/h10-11,13-14,20H,2-9H2,1H3 APPCZJXBJAFQOV-UHFFFAOYSA-N 155273 US9682966, 24::US10118915, Compound 24::US20250346584, Compound 24 Kappa-type opioid receptor Homo sapiens 120 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155273 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155273&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156217 355041325 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572469 CCOC(=O)c1cccnc1N1CCC(C1)NC1CCCCC1 InChI=1S/C18H27N3O2/c1-2-23-18(22)16-9-6-11-19-17(16)21-12-10-15(13-21)20-14-7-4-3-5-8-14/h6,9,11,14-15,20H,2-5,7-8,10,12-13H2,1H3 ULFJPYUUUOAQCJ-UHFFFAOYSA-N 155274 US9682966, 25::US10118915, Compound 25::US20250346584, Compound 25 Kappa-type opioid receptor Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155274 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155274&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263610 355041326 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572470 COC1CCCCC1NC1CCN(CC1)c1ncc(Br)cc1C(=O)OC |w:8.8,2.1| InChI=1S/C19H28BrN3O3/c1-25-17-6-4-3-5-16(17)22-14-7-9-23(10-8-14)18-15(19(24)26-2)11-13(20)12-21-18/h11-12,14,16-17,22H,3-10H2,1-2H3 FPOWWSVUDYAZPF-UHFFFAOYSA-N 155275 US9682966, 26::US10118915, Compound 26::US20250346584, Compound 26 Kappa-type opioid receptor Homo sapiens 267 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155275 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155275&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156235 355041327 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572471 COC(=O)c1cc(Br)cnc1N1CCC(N[C@@H]2CCCCC[C@H]2O)CC1 785496 US20250346584, Compound 27 Kappa-type opioid receptor Homo sapiens 473 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785496&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572472 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CC2CCC1C2 |TLB:17:18:21.22:24| InChI=1S/C19H26BrN3O2/c1-25-19(24)16-10-14(20)11-21-18(16)23-6-4-15(5-7-23)22-17-9-12-2-3-13(17)8-12/h10-13,15,17,22H,2-9H2,1H3 TUUHINWBQIZSRA-UHFFFAOYSA-N 155277 US9682966, 28::US10118915, Compound 28::US20250346584, Compound 28 Kappa-type opioid receptor Homo sapiens 387 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155277 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155277&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263614 355041329 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572473 COC(=O)c1cc(Br)cnc1N1CCC(CNC2CCCCC2)CC1 InChI=1S/C19H28BrN3O2/c1-25-19(24)17-11-15(20)13-22-18(17)23-9-7-14(8-10-23)12-21-16-5-3-2-4-6-16/h11,13-14,16,21H,2-10,12H2,1H3 KYIARVHKBVXESL-UHFFFAOYSA-N 155278 US9682966, 31::US10118915, Compound 31::US20250346584, Compound 31 Kappa-type opioid receptor Homo sapiens 3500 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155278&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156220 355041330 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572474 COC(=O)c1cc(cnc1N1CCC(CC1)NC1CCCCC1)-c1ccsc1 InChI=1S/C22H29N3O2S/c1-27-22(26)20-13-17(16-9-12-28-15-16)14-23-21(20)25-10-7-19(8-11-25)24-18-5-3-2-4-6-18/h9,12-15,18-19,24H,2-8,10-11H2,1H3 OFJASWNKYNLFOY-UHFFFAOYSA-N 155281 US9682966, 32::US10118915, Compound 32::US20250346584, Compound 32 Kappa-type opioid receptor Homo sapiens 5300 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155281&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263619 355041331 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572475 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(O)C1 InChI=1S/C18H26BrN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-15(16(23)11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 AJYHHWYDOWTOKZ-UHFFFAOYSA-N 155886 US9682966, 112::US10118915, Compound 112::US20250346584, Compound 112 Kappa-type opioid receptor Homo sapiens 16.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155886&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156214 355041422 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572476 OC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C17H24BrN3O2/c18-12-10-15(17(22)23)16(19-11-12)21-8-6-14(7-9-21)20-13-4-2-1-3-5-13/h10-11,13-14,20H,1-9H2,(H,22,23) JJSWLBZAYHLUNB-UHFFFAOYSA-N 155283 US9682966, 34::US10118915, Compound 34::US20250346584, Compound 34 Kappa-type opioid receptor Homo sapiens 5200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155283 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155283&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156224 355041333 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572477 COC(=O)c1cc(I)cnc1N1CCC(C1)NC1CCCCC1 InChI=1S/C17H24IN3O2/c1-23-17(22)15-9-12(18)10-19-16(15)21-8-7-14(11-21)20-13-5-3-2-4-6-13/h9-10,13-14,20H,2-8,11H2,1H3 YPCVQQFIIQNGFV-UHFFFAOYSA-N 155284 US9682966, 35::US10118915, Compound 35::US20250346584, Compound 35 Kappa-type opioid receptor Homo sapiens 88.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155284 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155284&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73294849 355041334 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572478 COC(=O)c1cc(I)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C18H26IN3O2/c1-24-18(23)16-11-13(19)12-20-17(16)22-9-7-15(8-10-22)21-14-5-3-2-4-6-14/h11-12,14-15,21H,2-10H2,1H3 YHUYJNSRYJOKFO-UHFFFAOYSA-N 155285 US9682966, 36::US10118915, Compound 36::US20250346584, Compound 36 Kappa-type opioid receptor Homo sapiens 79.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155285 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155285&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156232 355041335 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572479 COC(=O)c1cc(I)cnc1N1CCC(CC1)NC1CCCCC1O |w:17.19,23.26| InChI=1S/C18H26IN3O3/c1-25-18(24)14-10-12(19)11-20-17(14)22-8-6-13(7-9-22)21-15-4-2-3-5-16(15)23/h10-11,13,15-16,21,23H,2-9H2,1H3 GFBITCFPCUCOPI-UHFFFAOYSA-N 155287 US9682966, 37::US20250346584, Compound 37 Kappa-type opioid receptor Homo sapiens 142 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155287 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155287&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263620 355041336 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572480 CCOC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C19H28BrN3O2/c1-2-25-19(24)17-12-14(20)13-21-18(17)23-10-8-16(9-11-23)22-15-6-4-3-5-7-15/h12-13,15-16,22H,2-11H2,1H3 JPOQNLKBHIXKDE-UHFFFAOYSA-N 155288 US9682966, 38::US10118915, Compound 38::US20250346584, Compound 38 Kappa-type opioid receptor Homo sapiens 128 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155288 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155288&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73294850 355041337 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572481 CC(C)OC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C20H30BrN3O2/c1-14(2)26-20(25)18-12-15(21)13-22-19(18)24-10-8-17(9-11-24)23-16-6-4-3-5-7-16/h12-14,16-17,23H,3-11H2,1-2H3 ZOYZJDSQGLSKMJ-UHFFFAOYSA-N 155289 US9682966, 39::US10118915, Compound 39::US20250346584, Compound 39 Kappa-type opioid receptor Homo sapiens 398 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155289 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155289&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156234 355041338 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572482 COC(=O)c1cc(Cl)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C18H26ClN3O2/c1-24-18(23)16-11-13(19)12-20-17(16)22-9-7-15(8-10-22)21-14-5-3-2-4-6-14/h11-12,14-15,21H,2-10H2,1H3 GRLXORJUIODJLW-UHFFFAOYSA-N 155290 US9682966, 40::US10118915, Compound 40::US20250346584, Compound 40 Kappa-type opioid receptor Homo sapiens 159 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155290 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155290&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156212 355041339 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572483 Cc1noc(n1)-c1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C19H26BrN5O/c1-13-22-19(26-24-13)17-11-14(20)12-21-18(17)25-9-7-16(8-10-25)23-15-5-3-2-4-6-15/h11-12,15-16,23H,2-10H2,1H3 IMUPDUSTJFOCFK-UHFFFAOYSA-N 155291 US9682966, 41::US10118915, Compound 41::US20250346584, Compound 41 Kappa-type opioid receptor Homo sapiens 331 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155291 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155291&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295184 355041340 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572484 COC(=O)c1cc(I)cnc1N1CCC(NC2CCCCC2)C(O)C1 InChI=1S/C18H26IN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-15(16(23)11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 URRBLZISABMGSA-UHFFFAOYSA-N 155902 US9682966, 126::US10118915, Compound 126::US20250346584, Compound 126 Kappa-type opioid receptor Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155902&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295012 355041433 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572485 COC(=O)c1cc(Cl)cnc1N1CCC(NC2CCCCC2)C(O)C1 |w:14.15,22.24| InChI=1S/C18H26ClN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-15(16(23)11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 XBGQPUUPXLCNDB-UHFFFAOYSA-N 155293 US9682966, 43::US10118915, Compound 43::US20250346584, Compound 43 Kappa-type opioid receptor Homo sapiens 52.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155293 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155293&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263623 355041342 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572486 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCC2)C(O)C1 |w:14.15,21.23| InChI=1S/C17H24BrN3O3/c1-24-17(23)13-8-11(18)9-19-16(13)21-7-6-14(15(22)10-21)20-12-4-2-3-5-12/h8-9,12,14-15,20,22H,2-7,10H2,1H3 NVFWUCHVTPRXKY-UHFFFAOYSA-N 155294 US9682966, 44::US10118915, Compound 44::US20250346584, Compound 44 Kappa-type opioid receptor Homo sapiens 79.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155294 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155294&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295013 355041343 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572487 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(C)C1 |w:14.15,22.24| InChI=1S/C19H28BrN3O2/c1-13-12-23(9-8-17(13)22-15-6-4-3-5-7-15)18-16(19(24)25-2)10-14(20)11-21-18/h10-11,13,15,17,22H,3-9,12H2,1-2H3 XZXXLPIPCBQIPA-UHFFFAOYSA-N 155295 US9682966, 45::US10118915, Compound 45::US20250346584, Compound 45 Kappa-type opioid receptor Homo sapiens 164 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155295&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156231 355041344 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572488 COC(=O)c1cc(I)cnc1N1CCC(NC2CCCC2)C(O)C1 |w:14.15,21.23| InChI=1S/C17H24IN3O3/c1-24-17(23)13-8-11(18)9-19-16(13)21-7-6-14(15(22)10-21)20-12-4-2-3-5-12/h8-9,12,14-15,20,22H,2-7,10H2,1H3 LPEDZIUISVYTPH-UHFFFAOYSA-N 155296 US9682966, 46::US10118915, Compound 46::US20250346584, Compound 46 Kappa-type opioid receptor Homo sapiens 25.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155296 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155296&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295014 355041345 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572489 COC(=O)c1cc(Br)cnc1N1CCC(O)C(C1)NC1CCCCC1 InChI=1S/C18H26BrN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-16(23)15(11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 LOUPSVNZMVWMMK-UHFFFAOYSA-N 155297 US9682966, 47::US10118915, Compound 47::US20250346584, Compound 47 Kappa-type opioid receptor Homo sapiens 2800 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155297&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118267237 355041346 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572490 COC(=O)c1cc(Br)cnc1N1CC(O)C(C1)NC1CCCCC1 InChI=1S/C17H24BrN3O3/c1-24-17(23)13-7-11(18)8-19-16(13)21-9-14(15(22)10-21)20-12-5-3-2-4-6-12/h7-8,12,14-15,20,22H,2-6,9-10H2,1H3 ZWWDHDAEYNHHPF-UHFFFAOYSA-N 155298 US9682966, 48::US10118915, Compound 48::US20250346584, Compound 48 Kappa-type opioid receptor Homo sapiens 459 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155298 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155298&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263627 355041347 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572491 COC(=O)c1cc(Br)cnc1N1CC2CN(CC2C1)C1CCCCC1 InChI=1S/C19H26BrN3O2/c1-25-19(24)17-7-15(20)8-21-18(17)23-11-13-9-22(10-14(13)12-23)16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3 ZGJBZSWNOLYGAD-UHFFFAOYSA-N 155299 US9682966, 49::US10118915, Compound 49::US20250346584, Compound 49 Kappa-type opioid receptor Homo sapiens 1300 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155299 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155299&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263624 355041348 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572492 COC(=O)c1cc(Br)cnc1N1CC2CN(CC2C1)C1CCCC1 InChI=1S/C18H24BrN3O2/c1-24-18(23)16-6-14(19)7-20-17(16)22-10-12-8-21(9-13(12)11-22)15-4-2-3-5-15/h6-7,12-13,15H,2-5,8-11H2,1H3 ILTICQKSMGBDNC-UHFFFAOYSA-N 155301 US9682966, 50::US10118915, Compound 50::US20250346584, Compound 50 Kappa-type opioid receptor Homo sapiens 1000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155301 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155301&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263626 355041349 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572493 COC(=O)c1cc(Br)cnc1N1CCC(C(O)C1)N(C)C1CCCCC1 |w:14.19,15.16| InChI=1S/C19H28BrN3O3/c1-22(14-6-4-3-5-7-14)16-8-9-23(12-17(16)24)18-15(19(25)26-2)10-13(20)11-21-18/h10-11,14,16-17,24H,3-9,12H2,1-2H3 KCDRZYLPYPHIAT-UHFFFAOYSA-N 155302 US9682966, 51::US20250346584, Compound 51 Kappa-type opioid receptor Homo sapiens 3000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155302 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155302&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263625 355041350 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572494 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(F)C1 |w:14.15,22.24| InChI=1S/C18H25BrFN3O2/c1-25-18(24)14-9-12(19)10-21-17(14)23-8-7-16(15(20)11-23)22-13-5-3-2-4-6-13/h9-10,13,15-16,22H,2-8,11H2,1H3 PBVWJCXDXWPKAT-UHFFFAOYSA-N 155304 US9682966, 52::US10118915, Compound 52::US20250346584, Compound 52 Kappa-type opioid receptor Homo sapiens 3400 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155304 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155304&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263629 355041351 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572495 COC(=O)c1cccnc1N1CCC(NC2CCCCC2C)C(O)C1 |w:14.15| InChI=1S/C19H29N3O3/c1-13-6-3-4-8-15(13)21-16-9-11-22(12-17(16)23)18-14(19(24)25-2)7-5-10-20-18/h5,7,10,13,15-17,21,23H,3-4,6,8-9,11-12H2,1-2H3 UAHNCCDWUCERNS-UHFFFAOYSA-N 155305 US9682966, 53::US10118915, Compound 53::US20250346584, Compound 53 Kappa-type opioid receptor Homo sapiens 5600 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155305 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155305&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263628 355041352 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572496 COC1CCCCC1NC1CCN(CC1O)c1ncccc1C(=O)OC |w:8.8| InChI=1S/C19H29N3O4/c1-25-17-8-4-3-7-15(17)21-14-9-11-22(12-16(14)23)18-13(19(24)26-2)6-5-10-20-18/h5-6,10,14-17,21,23H,3-4,7-9,11-12H2,1-2H3 OLMUUGJYKANOFU-UHFFFAOYSA-N 155307 US9682966, 54::US10118915, Compound 54::US20250346584, Compound 54 Kappa-type opioid receptor Homo sapiens 559 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155307 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155307&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263630 355041353 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572497 COC(=O)c1cccnc1N1CCC(NC2CCCCCC2)C(O)C1 |w:14.15| InChI=1S/C19H29N3O3/c1-25-19(24)15-9-6-11-20-18(15)22-12-10-16(17(23)13-22)21-14-7-4-2-3-5-8-14/h6,9,11,14,16-17,21,23H,2-5,7-8,10,12-13H2,1H3 VXDYUTZWVLBJMS-UHFFFAOYSA-N 155308 US9682966, 55::US10118915, Compound 55::US20250346584, Compound 55 Kappa-type opioid receptor Homo sapiens 1800 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155308 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155308&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263631 355041354 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572498 COC(=O)c1cccnc1N1CCC(NC2CCOCC2)C(O)C1 |w:14.15| InChI=1S/C17H25N3O4/c1-23-17(22)13-3-2-7-18-16(13)20-8-4-14(15(21)11-20)19-12-5-9-24-10-6-12/h2-3,7,12,14-15,19,21H,4-6,8-11H2,1H3 LUKZTWVDBFFFHR-UHFFFAOYSA-N 155309 US9682966, 56::US10118915, Compound 56::US20250346584, Compound 56 Kappa-type opioid receptor Homo sapiens 7000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155309 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155309&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263632 355041355 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572499 COC(=O)c1cccnc1N1CCC(NC2CCCCC2)C(O)C1 |w:14.15| InChI=1S/C18H27N3O3/c1-24-18(23)14-8-5-10-19-17(14)21-11-9-15(16(22)12-21)20-13-6-3-2-4-7-13/h5,8,10,13,15-16,20,22H,2-4,6-7,9,11-12H2,1H3 AJNIGLAHOWKSPB-UHFFFAOYSA-N 155311 US9682966, 57::US10118915, Compound 57::US20250346584, Compound 57 Kappa-type opioid receptor Homo sapiens 2200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155311 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155311&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156209 355041356 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572500 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2C)C(O)C1 |w:15.16| InChI=1S/C19H28BrN3O3/c1-12-5-3-4-6-15(12)22-16-7-8-23(11-17(16)24)18-14(19(25)26-2)9-13(20)10-21-18/h9-10,12,15-17,22,24H,3-8,11H2,1-2H3 KDQPUEFWYCWHDT-UHFFFAOYSA-N 155312 US9682966, 58::US10118915, Compound 58::US20250346584, Compound 58 Kappa-type opioid receptor Homo sapiens 419 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155312 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155312&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263633 355041357 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572501 COC1CCCCC1NC1CCN(CC1O)c1ncc(Br)cc1C(=O)OC |w:8.8| InChI=1S/C19H28BrN3O4/c1-26-17-6-4-3-5-15(17)22-14-7-8-23(11-16(14)24)18-13(19(25)27-2)9-12(20)10-21-18/h9-10,14-17,22,24H,3-8,11H2,1-2H3 FVOAJIDIFXEKSF-UHFFFAOYSA-N 155313 US9682966, 59::US10118915, Compound 59::US20250346584, Compound 59 Kappa-type opioid receptor Homo sapiens 36.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155313 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155313&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263634 355041358 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572502 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCCC2)C(O)C1 InChI=1S/C19H28BrN3O3/c1-26-19(25)15-10-13(20)11-21-18(15)23-9-8-16(17(24)12-23)22-14-6-4-2-3-5-7-14/h10-11,14,16-17,22,24H,2-9,12H2,1H3 OZVWIIIBZJJMPL-UHFFFAOYSA-N 155314 US9682966, 60::US10118915, Compound 60::US20250346584, Compound 60 Kappa-type opioid receptor Homo sapiens 68.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155314&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263635 355041359 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572503 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCOCC2)C(O)C1 InChI=1S/C17H24BrN3O4/c1-24-17(23)13-8-11(18)9-19-16(13)21-5-2-14(15(22)10-21)20-12-3-6-25-7-4-12/h8-9,12,14-15,20,22H,2-7,10H2,1H3 NLJHMTRNWRGHFA-UHFFFAOYSA-N 155315 US9682966, 61::US10118915, Compound 61::US20250346584, Compound 61 Kappa-type opioid receptor Homo sapiens 54.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155315&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263636 355041360 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572504 COC(=O)c1cc(Br)cnc1N1CC(O)C(NC2CCCCC2)C(O)C1 |w:16.17| InChI=1S/C18H26BrN3O4/c1-26-18(25)13-7-11(19)8-20-17(13)22-9-14(23)16(15(24)10-22)21-12-5-3-2-4-6-12/h7-8,12,14-16,21,23-24H,2-6,9-10H2,1H3 IGHZTASPNLKYNR-UHFFFAOYSA-N 155316 US9682966, 62::US10118915, Compound 62::US20250346584, Compound 62 Kappa-type opioid receptor Homo sapiens 2700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155316 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155316&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263638 355041361 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572505 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(C)(C)C1 |w:15.16| InChI=1S/C20H30BrN3O2/c1-20(2)13-24(10-9-17(20)23-15-7-5-4-6-8-15)18-16(19(25)26-3)11-14(21)12-22-18/h11-12,15,17,23H,4-10,13H2,1-3H3 SYHZUCONNYTSKD-UHFFFAOYSA-N 155317 US9682966, 63::US10118915, Compound 63::US20250346584, Compound 63 Kappa-type opioid receptor Homo sapiens 234 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155317 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155317&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263637 355041362 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572506 COC(=O)c1cc(Br)cnc1N1CCC(CC1C)NC1CCCCC1 |w:18.20| InChI=1S/C19H28BrN3O2/c1-13-10-16(22-15-6-4-3-5-7-15)8-9-23(13)18-17(19(24)25-2)11-14(20)12-21-18/h11-13,15-16,22H,3-10H2,1-2H3 HSPIWRZNOWJTOF-UHFFFAOYSA-N 155318 US9682966, 64::US10118915, Compound 64::US20250346584, Compound 64 Kappa-type opioid receptor Homo sapiens 901 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155318 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155318&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263639 355041363 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572507 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1CO |w:17.19,23.26| InChI=1S/C19H28BrN3O3/c1-26-19(25)16-10-14(20)11-21-18(16)23-8-6-15(7-9-23)22-17-5-3-2-4-13(17)12-24/h10-11,13,15,17,22,24H,2-9,12H2,1H3 JYSWYNGHSNZVHP-UHFFFAOYSA-N 155319 US9682966, 65::US10118915, Compound 65::US20250346584, Compound 65 Kappa-type opioid receptor Homo sapiens 2300 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155319 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155319&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263641 355041364 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572508 COC(=O)c1cc(Br)cnc1N1CCCC(CC1)NC1CCCCC1 InChI=1S/C19H28BrN3O2/c1-25-19(24)17-12-14(20)13-21-18(17)23-10-5-8-16(9-11-23)22-15-6-3-2-4-7-15/h12-13,15-16,22H,2-11H2,1H3 FDDJNKDXDASFQE-UHFFFAOYSA-N 155322 US9682966, 66::US10118915, Compound 66::US20250346584, Compound 66 Kappa-type opioid receptor Homo sapiens 1700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155322 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155322&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263643 355041365 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572509 COC(=O)c1cc(Br)cnc1N1CC(C1)NC1CCCCC1 InChI=1S/C16H22BrN3O2/c1-22-16(21)14-7-11(17)8-18-15(14)20-9-13(10-20)19-12-5-3-2-4-6-12/h7-8,12-13,19H,2-6,9-10H2,1H3 MYYVKGIRWFWYNM-UHFFFAOYSA-N 155323 US9682966, 67::US10118915, Compound 67::US20250346584, Compound 67 Kappa-type opioid receptor Homo sapiens 1400 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155323 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155323&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263645 355041366 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572510 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C19H28BrN3O3/c1-26-19(25)16-9-14(20)10-21-18(16)23-8-7-17(13(11-23)12-24)22-15-5-3-2-4-6-15/h9-10,13,15,17,22,24H,2-8,11-12H2,1H3 SHVMHFIXQMGANQ-UHFFFAOYSA-N 155324 US9682966, 68::US10118915, Compound 68::US20250346584, Compound 68 Kappa-type opioid receptor Homo sapiens 40.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155324 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155324&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263648 355041367 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572511 CCOC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C20H30BrN3O3/c1-2-27-20(26)17-10-15(21)11-22-19(17)24-9-8-18(14(12-24)13-25)23-16-6-4-3-5-7-16/h10-11,14,16,18,23,25H,2-9,12-13H2,1H3 IWQUMAAOJJESGY-UHFFFAOYSA-N 155325 US9682966, 69::US10118915, Compound 69::US20250346584, Compound 69 Kappa-type opioid receptor Homo sapiens 53.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155325 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155325&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263649 355041368 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572512 COC(=O)c1cc(Cl)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C19H28ClN3O3/c1-26-19(25)16-9-14(20)10-21-18(16)23-8-7-17(13(11-23)12-24)22-15-5-3-2-4-6-15/h9-10,13,15,17,22,24H,2-8,11-12H2,1H3 SYMQACOROWVRCV-UHFFFAOYSA-N 155326 US9682966, 70::US10118915, Compound 70::US20250346584, Compound 70 Kappa-type opioid receptor Homo sapiens 110 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155326 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155326&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263651 355041369 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572513 CCOC(=O)c1cc(Cl)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C20H30ClN3O3/c1-2-27-20(26)17-10-15(21)11-22-19(17)24-9-8-18(14(12-24)13-25)23-16-6-4-3-5-7-16/h10-11,14,16,18,23,25H,2-9,12-13H2,1H3 MMSKEZHEVUCQTA-UHFFFAOYSA-N 155327 US9682966, 71::US10118915, Compound 71::US20250346584, Compound 71 Kappa-type opioid receptor Homo sapiens 93.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155327 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155327&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263652 355041370 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572514 COC(=O)c1cc(F)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C18H26FN3O2/c1-24-18(23)16-11-13(19)12-20-17(16)22-9-7-15(8-10-22)21-14-5-3-2-4-6-14/h11-12,14-15,21H,2-10H2,1H3 GHJNXCOSOUYPGX-UHFFFAOYSA-N 155328 US9682966, 72::US10118915, Compound 72::US20250346584, Compound 72 Kappa-type opioid receptor Homo sapiens 6600 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155328 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155328&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156227 355041371 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572515 COC1CN(CCC1NC1CCCCC1)c1ncc(Br)cc1C(=O)OC InChI=1S/C19H28BrN3O3/c1-25-17-12-23(9-8-16(17)22-14-6-4-3-5-7-14)18-15(19(24)26-2)10-13(20)11-21-18/h10-11,14,16-17,22H,3-9,12H2,1-2H3 USNDYJLCUCYRAZ-UHFFFAOYSA-N 155898 US9682966, 122::US10118915, Compound 122::US20250346584, Compound 122 Kappa-type opioid receptor Homo sapiens 205 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155898&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263653 355041430 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572516 COC(=O)c1cc(Br)cnc1N1CC2C(C1)C2NC1CCCCC1 InChI=1S/C18H24BrN3O2/c1-24-18(23)13-7-11(19)8-20-17(13)22-9-14-15(10-22)16(14)21-12-5-3-2-4-6-12/h7-8,12,14-16,21H,2-6,9-10H2,1H3 CSEGOEORTNNMFW-UHFFFAOYSA-N 155330 US9682966, C27::US10118915, Compound C27::US20250346584, Compound C27 Kappa-type opioid receptor Homo sapiens 21000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155330&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263654 355041373 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572517 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCCC2)C(CO)C1 InChI=1S/C20H30BrN3O3/c1-27-20(26)17-10-15(21)11-22-19(17)24-9-8-18(14(12-24)13-25)23-16-6-4-2-3-5-7-16/h10-11,14,16,18,23,25H,2-9,12-13H2,1H3 LBOACWKETIIRSJ-UHFFFAOYSA-N 155331 US9682966, 74::US10118915, Compound 74::US20250346584, Compound 74 Kappa-type opioid receptor Homo sapiens 58.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155331&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263655 355041374 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572518 COC(=O)c1cc(I)cnc1N1CCC(NC2CCCCCC2)C(CO)C1 InChI=1S/C20H30IN3O3/c1-27-20(26)17-10-15(21)11-22-19(17)24-9-8-18(14(12-24)13-25)23-16-6-4-2-3-5-7-16/h10-11,14,16,18,23,25H,2-9,12-13H2,1H3 NAMZCUSZHHCHCJ-UHFFFAOYSA-N 155332 US9682966, 75::US10118915, Compound 75::US20250346584, Compound 75 Kappa-type opioid receptor Homo sapiens 36.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155332 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155332&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295017 355041375 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572519 OCc1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1 |w:12.16| InChI=1S/C17H26BrN3O/c18-14-10-13(12-22)17(19-11-14)21-8-6-16(7-9-21)20-15-4-2-1-3-5-15/h10-11,15-16,20,22H,1-9,12H2 FALRPOVSPMZDAJ-UHFFFAOYSA-N 155333 US9682966, 76::US10118915, Compound 76::US20250346584, Compound 76 Kappa-type opioid receptor Homo sapiens 11300 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155333 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155333&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295185 355041376 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572520 COC(=O)c1cc(I)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C19H28IN3O3/c1-26-19(25)16-9-14(20)10-21-18(16)23-8-7-17(13(11-23)12-24)22-15-5-3-2-4-6-15/h9-10,13,15,17,22,24H,2-8,11-12H2,1H3 GSZUWWQTXIBGRU-UHFFFAOYSA-N 155336 US9682966, 77::US10118915, Compound 77::US20250346584, Compound 77 Kappa-type opioid receptor Homo sapiens 11.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155336 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155336&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295186 355041377 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572521 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CC1 |w:14.18| InChI=1S/C15H20BrN3O2/c1-21-15(20)13-8-10(16)9-17-14(13)19-6-4-12(5-7-19)18-11-2-3-11/h8-9,11-12,18H,2-7H2,1H3 SZKROPLTKYPEFJ-UHFFFAOYSA-N 155337 US9682966, 78::US10118915, Compound 78::US20250346584, Compound 78 Kappa-type opioid receptor Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155337&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295187 355041378 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572522 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCC2)C(CO)C1 InChI=1S/C18H26BrN3O3/c1-25-18(24)15-8-13(19)9-20-17(15)22-7-6-16(12(10-22)11-23)21-14-4-2-3-5-14/h8-9,12,14,16,21,23H,2-7,10-11H2,1H3 FCKZCDFWTDGKPJ-UHFFFAOYSA-N 155338 US9682966, 79::US10118915, Compound 79::US20250346584, Compound 79 Kappa-type opioid receptor Homo sapiens 25.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155338 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155338&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295188 355041379 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572523 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2C)C(CO)C1 |w:15.16,21.23| InChI=1S/C20H30BrN3O3/c1-13-5-3-4-6-17(13)23-18-7-8-24(11-14(18)12-25)19-16(20(26)27-2)9-15(21)10-22-19/h9-10,13-14,17-18,23,25H,3-8,11-12H2,1-2H3 CXMZVUJUIVZRCH-UHFFFAOYSA-N 155339 US9682966, 80::US10118915, Compound 80::US20250346584, Compound 80 Kappa-type opioid receptor Homo sapiens 87.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155339 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155339&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295189 355041380 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572524 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCOCC2)C(CO)C1 InChI=1S/C18H26BrN3O4/c1-25-18(24)15-8-13(19)9-20-17(15)22-5-2-16(12(10-22)11-23)21-14-3-6-26-7-4-14/h8-9,12,14,16,21,23H,2-7,10-11H2,1H3 DCRRLGBBBFRUMB-UHFFFAOYSA-N 155340 US9682966, 81::US10118915, Compound 81::US20250346584, Compound 81 Kappa-type opioid receptor Homo sapiens 126 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155340 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155340&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295190 355041381 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572525 COC1CCCCC1NC1CCN(CC1CO)c1ncc(Br)cc1C(=O)OC |w:8.8,2.1| InChI=1S/C20H30BrN3O4/c1-27-18-6-4-3-5-17(18)23-16-7-8-24(11-13(16)12-25)19-15(20(26)28-2)9-14(21)10-22-19/h9-10,13,16-18,23,25H,3-8,11-12H2,1-2H3 BLORCJMXBSDGIZ-UHFFFAOYSA-N 155670 US9682966, 82::US10118915, Compound 82::US20250346584, Compound 82 Kappa-type opioid receptor Homo sapiens 127 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155670 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155670&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295521 355041382 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572526 COC(=O)c1cc(Br)cnc1N1CCC(N)C(O)C1 |w:14.15,16.17| InChI=1S/C12H16BrN3O3/c1-19-12(18)8-4-7(13)5-15-11(8)16-3-2-9(14)10(17)6-16/h4-5,9-10,17H,2-3,6,14H2,1H3 QFTVVHIQSNGZPF-UHFFFAOYSA-N 155674 US9682966, 83::US10118915, Compound 83::US20250346584, Compound 83 Kappa-type opioid receptor Homo sapiens 5900 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155674&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156208 355041383 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572527 COC(=O)c1cc(cnc1N1CCC(CC1)NC1CCCCC1)[N+]([O-])=O |w:13.17| InChI=1S/C18H26N4O4/c1-26-18(23)16-11-15(22(24)25)12-19-17(16)21-9-7-14(8-10-21)20-13-5-3-2-4-6-13/h11-14,20H,2-10H2,1H3 VWQFJCYEMZRMII-UHFFFAOYSA-N 155761 US9682966, 84::US10118915, Compound 84::US20250346584, Compound 84 Kappa-type opioid receptor Homo sapiens 6200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155761&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295353 355041384 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572528 COC(=O)c1cc(N)cnc1N1CCC(CC1)NC1CCCCC1 |w:14.18| InChI=1S/C18H28N4O2/c1-24-18(23)16-11-13(19)12-20-17(16)22-9-7-15(8-10-22)21-14-5-3-2-4-6-14/h11-12,14-15,21H,2-10,19H2,1H3 YWCUHKBNXJKANE-UHFFFAOYSA-N 155848 US9682966, 85::US10118915, Compound 85::US20250346584, Compound 85 Kappa-type opioid receptor Homo sapiens 1800 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155848&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295354 355041385 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572529 COC(=O)c1cc(NC(C)=O)cnc1N1CCC(CC1)NC1CCCCC1 |w:17.21| InChI=1S/C20H30N4O3/c1-14(25)22-17-12-18(20(26)27-2)19(21-13-17)24-10-8-16(9-11-24)23-15-6-4-3-5-7-15/h12-13,15-16,23H,3-11H2,1-2H3,(H,22,25) BOZWSLSLVQFFIA-UHFFFAOYSA-N 155849 US9682966, 86::US10118915, Compound 86::US20250346584, Compound 86 Kappa-type opioid receptor Homo sapiens 628 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155849&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156213 355041386 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572530 CNC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1 |w:14.18| InChI=1S/C18H27BrN4O/c1-20-18(24)16-11-13(19)12-21-17(16)23-9-7-15(8-10-23)22-14-5-3-2-4-6-14/h11-12,14-15,22H,2-10H2,1H3,(H,20,24) FOHCCNWCJMORPU-UHFFFAOYSA-N 155850 US9682966, 87::US10118915, Compound 87::US20250346584, Compound 87 Kappa-type opioid receptor Homo sapiens 19000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155850&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295355 355041387 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572531 COC(=O)c1cc(I)cnc1N1CCC(NC2CCCC2)C(CO)C1 InChI=1S/C18H26IN3O3/c1-25-18(24)15-8-13(19)9-20-17(15)22-7-6-16(12(10-22)11-23)21-14-4-2-3-5-14/h8-9,12,14,16,21,23H,2-7,10-11H2,1H3 CTTCAFXJMWZZMA-UHFFFAOYSA-N 155851 US9682966, 88::US10118915, Compound 88::US20250346584, Compound 88 Kappa-type opioid receptor Homo sapiens 52.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155851&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295356 355041388 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572532 COC(=O)c1cc(I)cnc1N1CCC(NC2CCCCC2C)C(CO)C1 |w:15.16,21.23| InChI=1S/C20H30IN3O3/c1-13-5-3-4-6-17(13)23-18-7-8-24(11-14(18)12-25)19-16(20(26)27-2)9-15(21)10-22-19/h9-10,13-14,17-18,23,25H,3-8,11-12H2,1-2H3 WYHFUJLWYUTAGT-UHFFFAOYSA-N 155852 US9682966, 89::US10118915, Compound 89::US20250346584, Compound 89 Kappa-type opioid receptor Homo sapiens 116 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155852&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295357 355041389 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572533 COC(=O)c1cc(I)cnc1N1CCC(NC2CCOCC2)C(CO)C1 InChI=1S/C18H26IN3O4/c1-25-18(24)15-8-13(19)9-20-17(15)22-5-2-16(12(10-22)11-23)21-14-3-6-26-7-4-14/h8-9,12,14,16,21,23H,2-7,10-11H2,1H3 LCWKHDUNEHKMPB-UHFFFAOYSA-N 155853 US9682966, 90::US10118915, Compound 90::US20250346584, Compound 90 Kappa-type opioid receptor Homo sapiens 186 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155853&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295522 355041390 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572534 COC1CCCCC1NC1CCN(CC1CO)c1ncc(I)cc1C(=O)OC |w:8.8,2.1| InChI=1S/C20H30IN3O4/c1-27-18-6-4-3-5-17(18)23-16-7-8-24(11-13(16)12-25)19-15(20(26)28-2)9-14(21)10-22-19/h9-10,13,16-18,23,25H,3-8,11-12H2,1-2H3 OYDOPLQXNQBSCZ-UHFFFAOYSA-N 155854 US9682966, 91::US10118915, Compound 91::US20250346584, Compound 91 Kappa-type opioid receptor Homo sapiens 198 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155854&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295523 355041391 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572535 CCOC(=O)c1cc(C(=O)OC)c(C)nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C22H33N3O4/c1-4-29-22(27)19-14-18(21(26)28-3)15(2)23-20(19)25-12-10-17(11-13-25)24-16-8-6-5-7-9-16/h14,16-17,24H,4-13H2,1-3H3 KNTDZRQKNDMTFP-UHFFFAOYSA-N 155855 US9682966, 92::US10118915, Compound 92::US20250346584, Compound 92 Kappa-type opioid receptor Homo sapiens 2600 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155855&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156236 355041392 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572536 CCOC(=O)c1cc(C(=O)OC)c(C)nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C23H35N3O5/c1-4-31-23(29)19-12-18(22(28)30-3)15(2)24-21(19)26-11-10-20(16(13-26)14-27)25-17-8-6-5-7-9-17/h12,16-17,20,25,27H,4-11,13-14H2,1-3H3 MCPUTVVZDLSIHP-UHFFFAOYSA-N 155856 US9682966, 93::US10118915, Compound 93::US20250346584, Compound 93 Kappa-type opioid receptor Homo sapiens 621 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155856&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295524 355041393 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572537 CCOC(=O)c1cc(C(=O)OC)c(C)nc1N1CCC(NC2CCCCC2)C(O)C1 |w:19.20,27.29| InChI=1S/C22H33N3O5/c1-4-30-22(28)17-12-16(21(27)29-3)14(2)23-20(17)25-11-10-18(19(26)13-25)24-15-8-6-5-7-9-15/h12,15,18-19,24,26H,4-11,13H2,1-3H3 QPZOVLZRMYWUBI-UHFFFAOYSA-N 155857 US9682966, 94::US10118915, Compound 94::US20250346584, Compound 94 Kappa-type opioid receptor Homo sapiens 61.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155857&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295525 355041394 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572538 CCCC(=O)Nc1cnc(N2CCC(CC2)NC2CCCCC2)c(c1)C(=O)OC InChI=1S/C22H34N4O3/c1-3-7-20(27)25-18-14-19(22(28)29-2)21(23-15-18)26-12-10-17(11-13-26)24-16-8-5-4-6-9-16/h14-17,24H,3-13H2,1-2H3,(H,25,27) UAMAEHXHDGMPPG-UHFFFAOYSA-N 155858 US9682966, 95::US10118915, Compound 95::US20250346584, Compound 95 Kappa-type opioid receptor Homo sapiens 1.40 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155858 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155858&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295858 355041395 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572539 COC(=O)c1cc(NC(=O)NC(C)C)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C22H35N5O3/c1-15(2)24-22(29)26-18-13-19(21(28)30-3)20(23-14-18)27-11-9-17(10-12-27)25-16-7-5-4-6-8-16/h13-17,25H,4-12H2,1-3H3,(H2,24,26,29) HJPYEGZUGWVYAS-UHFFFAOYSA-N 155859 US9682966, C35::US10118915, Compound C35::US20250346584, Compound C35 Kappa-type opioid receptor Homo sapiens 17000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155859&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118267212 355041396 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572540 COC(=O)c1cnc(N2CCC(CC2)NC2CCCCC2)c(c1)[N+]([O-])=O InChI=1S/C18H26N4O4/c1-26-18(23)13-11-16(22(24)25)17(19-12-13)21-9-7-15(8-10-21)20-14-5-3-2-4-6-14/h11-12,14-15,20H,2-10H2,1H3 VNFRSVBUBYOQBC-UHFFFAOYSA-N 155860 US9682966, C36::US10118915, Compound C36::US20250346584, Compound C36 Kappa-type opioid receptor Homo sapiens 17000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155860 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155860&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263659 355041397 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572541 Cc1cnc(N2CCC(NC3CCCCC3)CC2)c(Br)c1 785567 US20250346584, Compound C43 Kappa-type opioid receptor Homo sapiens 15000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785567 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785567&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572542 CC(=O)c1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C18H26BrN3O/c1-13(23)17-11-14(19)12-20-18(17)22-9-7-16(8-10-22)21-15-5-3-2-4-6-15/h11-12,15-16,21H,2-10H2,1H3 NGTWQYXZTCKEAD-UHFFFAOYSA-N 155862 US9682966, 96::US10118915, Compound 96::US20250346584, Compound 96 Kappa-type opioid receptor Homo sapiens 6700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155862 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155862&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263666 355041399 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572543 CC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C19H28BrN3O2/c1-13(25)17-9-15(20)10-21-19(17)23-8-7-18(14(11-23)12-24)22-16-5-3-2-4-6-16/h9-10,14,16,18,22,24H,2-8,11-12H2,1H3 CIEWZDCRJWZZSY-UHFFFAOYSA-N 155863 US9682966, 144::US9682966, 97::US10118915, Compound 144::US20250346584, Compound 144 Kappa-type opioid receptor Homo sapiens 2000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155863&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263667 355041400 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572544 COC(=O)c1cc(cnc1N1CCC(NC2CCCCC2)C(O)C1)[N+]([O-])=O |w:13.14,21.23| InChI=1S/C18H26N4O5/c1-27-18(24)14-9-13(22(25)26)10-19-17(14)21-8-7-15(16(23)11-21)20-12-5-3-2-4-6-12/h9-10,12,15-16,20,23H,2-8,11H2,1H3 JLTODJAOWRVIND-UHFFFAOYSA-N 155864 US9682966, 98::US10118915, Compound 98::US20250346584, Compound 98 Kappa-type opioid receptor Homo sapiens 1100 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155864 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155864&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263668 355041401 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572545 CC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(O)C1 |w:13.14,21.23| InChI=1S/C18H26BrN3O2/c1-12(23)15-9-13(19)10-20-18(15)22-8-7-16(17(24)11-22)21-14-5-3-2-4-6-14/h9-10,14,16-17,21,24H,2-8,11H2,1H3 MFCYOQGAGIMECE-UHFFFAOYSA-N 155865 US9682966, 99::US10118915, Compound 99::US20250346584, Compound 99 Kappa-type opioid receptor Homo sapiens 4500 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155865 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155865&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263669 355041402 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572546 N=Cc1cc(Br)cnc1N1CCC(NC2CCCCC2)CC1 785572 US20250346584, Compound 100 Kappa-type opioid receptor Homo sapiens 292 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785572&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572547 N=Cc1cc(Br)cnc1N1CCC(NC2CCCCC2)CC1 785573 US20250346584, Compound 101 Kappa-type opioid receptor Homo sapiens 4000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785573&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572548 Cc1cnc(N2CCC(NC3CCCCC3)C(CO)C2)c(Br)c1 785574 US20250346584, Compound 102 Kappa-type opioid receptor Homo sapiens 13000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785574&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572549 Cc1cnc(N2CCC(NC3CCCCC3)C(O)C2)c(Br)c1 785575 US20250346584, Compound 103 Kappa-type opioid receptor Homo sapiens 137 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785575&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572550 CCOC(=O)c1cc(C(=O)OC)c(C)nc1N1CCC(C1)NC1CCCCC1 InChI=1S/C21H31N3O4/c1-4-28-21(26)18-12-17(20(25)27-3)14(2)22-19(18)24-11-10-16(13-24)23-15-8-6-5-7-9-15/h12,15-16,23H,4-11,13H2,1-3H3 OJQHJGCOTLHNTC-UHFFFAOYSA-N 155870 US9682966, 104::US10118915, Compound 104::US20250346584, Compound 104 Kappa-type opioid receptor Homo sapiens 2200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155870 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155870&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263676 355041406 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572551 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(C1)OC(C)=O |w:14.15,22.26| InChI=1S/C20H28BrN3O4/c1-13(25)28-18-12-24(9-8-17(18)23-15-6-4-3-5-7-15)19-16(20(26)27-2)10-14(21)11-22-19/h10-11,15,17-18,23H,3-9,12H2,1-2H3 YMNMGARWXHDCGG-UHFFFAOYSA-N 155871 US9682966, C49::US10118915, Compound C49::US20250346584, Compound C49 Kappa-type opioid receptor Homo sapiens 17000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155871 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155871&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263678 355041407 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572552 COC(=O)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C18H26BrN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-15(16(23)11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 AJYHHWYDOWTOKZ-UHFFFAOYSA-N 50012149 CHEMBL3264446::US9682966, 105::US10118915, Compound 105::US20250346584, Compound 105 Kappa-type opioid receptor Homo sapiens 56.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012149&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295685 242058074 CHEMBL3264446 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572553 COC(=O)c1cc(I)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C18H26IN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-15(16(23)11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 URRBLZISABMGSA-UHFFFAOYSA-N 155873 US9682966, 106::US10118915, Compound 106::US20250346584, Compound 106 Kappa-type opioid receptor Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155873 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155873&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295686 355041409 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572554 CCc1noc(n1)-c1cc(Br)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C20H28BrN5O/c1-2-18-24-20(27-25-18)17-12-14(21)13-22-19(17)26-10-8-16(9-11-26)23-15-6-4-3-5-7-15/h12-13,15-16,23H,2-11H2,1H3 ALAAPOSRCINHLC-UHFFFAOYSA-N 155874 US9682966, 107::US10118915, Compound 107::US20250346584, Compound 107 Kappa-type opioid receptor Homo sapiens 11000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155874 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155874&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263683 355041410 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572555 COC(=O)c1cc(C)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C19H29N3O2/c1-14-12-17(19(23)24-2)18(20-13-14)22-10-8-16(9-11-22)21-15-6-4-3-5-7-15/h12-13,15-16,21H,3-11H2,1-2H3 VCGXMJPYONECSM-UHFFFAOYSA-N 155875 US9682966, 108::US10118915, Compound 108::US20250346584, Compound 108 Kappa-type opioid receptor Homo sapiens 404 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155875 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155875&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295688 355041411 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572556 COC(=O)c1cc(C)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C20H31N3O3/c1-14-10-17(20(25)26-2)19(21-11-14)23-9-8-18(15(12-23)13-24)22-16-6-4-3-5-7-16/h10-11,15-16,18,22,24H,3-9,12-13H2,1-2H3 ISQXAXKHXAXMAT-UHFFFAOYSA-N 155876 US9682966, 109::US10118915, Compound 109::US20250346584, Compound 109 Kappa-type opioid receptor Homo sapiens 198 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155876 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155876&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263679 355041412 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572557 COC(=O)c1cc(C)cnc1N1CCC(NC2CCCCC2)C(O)C1 |w:14.15,22.24| InChI=1S/C19H29N3O3/c1-13-10-15(19(24)25-2)18(20-11-13)22-9-8-16(17(23)12-22)21-14-6-4-3-5-7-14/h10-11,14,16-17,21,23H,3-9,12H2,1-2H3 DSOAWSJNPHFMRE-UHFFFAOYSA-N 155877 US9682966, 110::US10118915, Compound 110::US20250346584, Compound 110 Kappa-type opioid receptor Homo sapiens 108 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155877&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263680 355041413 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572558 COC(=O)c1cc(Br)cnc1N1CCC(CC1)OC1CCCC1O |w:17.19,22.25| InChI=1S/C17H23BrN2O4/c1-23-17(22)13-9-11(18)10-19-16(13)20-7-5-12(6-8-20)24-15-4-2-3-14(15)21/h9-10,12,14-15,21H,2-8H2,1H3 REZTZPAYUHTCTO-UHFFFAOYSA-N 155878 US9682966, C51::US10118915, Compound C51::US20250346584, Compound C51 Kappa-type opioid receptor Homo sapiens >20000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155878&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263681 355041414 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572559 CCOC(=O)c1cc(C#N)c(C)nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C22H32N4O3/c1-4-29-22(28)18-12-20(23-3)15(2)24-21(18)26-11-10-19(16(13-26)14-27)25-17-8-6-5-7-9-17/h12,16-17,19,25,27H,4-11,13-14H2,1-2H3 CIAUCWKJHOAKQW-UHFFFAOYSA-N 155879 US9682966, C52::US10118915, Compound C52::US20250346584, Compound C52 Kappa-type opioid receptor Homo sapiens >20000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155879&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 123998722 355041415 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572560 CCOC(=O)c1cc(C#N)c(C)nc1N1CCC(NC2CCCCC2)C(O)C1 InChI=1S/C21H30N4O3/c1-4-28-21(27)16-12-18(22-3)14(2)23-20(16)25-11-10-17(19(26)13-25)24-15-8-6-5-7-9-15/h12,15,17,19,24,26H,4-11,13H2,1-2H3 CLTFZGAVOYTSQW-UHFFFAOYSA-N 155880 US9682966, C53::US10118915, Compound C53::US20250346584, Compound C53 Kappa-type opioid receptor Homo sapiens 13000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155880&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 123932254 355041416 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572561 COC(=O)c1cc(Br)cnc1N1CCC(NC(=O)C2CCCCC2)C(O)C1 |w:14.15,24.26| InChI=1S/C19H26BrN3O4/c1-27-19(26)14-9-13(20)10-21-17(14)23-8-7-15(16(24)11-23)22-18(25)12-5-3-2-4-6-12/h9-10,12,15-16,24H,2-8,11H2,1H3,(H,22,25) CTAJMWYAAXDZSI-UHFFFAOYSA-N 155881 US9682966, C54::US10118915, Compound C54::US20250346584, Compound C54 Kappa-type opioid receptor Homo sapiens >20000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155881&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263682 355041417 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572562 COC(=O)c1cc(Cl)cnc1N1CC[C@H](NC2CCCCC2)[C@@H](O)C1 |r| InChI=1S/C18H26ClN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-15(16(23)11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 XBGQPUUPXLCNDB-UHFFFAOYSA-N 155882 US9682966, 111::US10118915, Compound 111::US20250346584, Compound 111 Kappa-type opioid receptor Homo sapiens 281 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155882&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295689 355041418 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572563 COC(=O)c3cc(C#N)c(N2CCC(NC1CCCCC1)CC2)nc3C 785589 US20250346584, Compound C55 Kappa-type opioid receptor Homo sapiens >20000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785589&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572564 COC(=O)c3cc(C#N)c(N2CCC(NC1CCCCC1)C(CO)C2)nc3C 785590 US20250346584, Compound C56 Kappa-type opioid receptor Homo sapiens >20000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785590&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572565 COC(=O)c3cc(C#N)c(N2CCC(NC1CCCCC1)C(O)C2)nc3C 785591 US20250346584, Compound C57 Kappa-type opioid receptor Homo sapiens >20000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785591&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572566 COC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(O)C1 InChI=1S/C18H26BrN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-15(16(23)11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 AJYHHWYDOWTOKZ-UHFFFAOYSA-N 155886 US9682966, 112::US10118915, Compound 112::US20250346584, Compound 112 Kappa-type opioid receptor Homo sapiens 714 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155886&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 60156214 355041422 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572567 COC(=O)c1cc(Br)cnc1N1CCC(CC1)NC(=O)C1CCCCC1 InChI=1S/C19H26BrN3O3/c1-26-19(25)16-11-14(20)12-21-17(16)23-9-7-15(8-10-23)22-18(24)13-5-3-2-4-6-13/h11-13,15H,2-10H2,1H3,(H,22,24) QUOHGSRTQLPCGO-UHFFFAOYSA-N 155887 US9682966, C58::US10118915, Compound C58::US20250346584, Compound C58 Kappa-type opioid receptor Homo sapiens >20000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155887&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263687 355041423 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572568 COC(=O)C1CN(CCC1NC1CCCCC1)c1ncc(Br)cc1C(=O)OC InChI=1S/C20H28BrN3O4/c1-27-19(25)15-10-13(21)11-22-18(15)24-9-8-17(16(12-24)20(26)28-2)23-14-6-4-3-5-7-14/h10-11,14,16-17,23H,3-9,12H2,1-2H3 ZKCPSGKBRIBROO-UHFFFAOYSA-N 155888 US9682966, 116::US9682966, 113::US10118915, Compound 116::US20250346584, Compound 116 Kappa-type opioid receptor Homo sapiens 2000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155888&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295690 355041424 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572569 COC(=O)C1CN(CCC1NC1CCCC1)c1ncc(Br)cc1C(=O)OC InChI=1S/C19H26BrN3O4/c1-26-18(24)14-9-12(20)10-21-17(14)23-8-7-16(15(11-23)19(25)27-2)22-13-5-3-4-6-13/h9-10,13,15-16,22H,3-8,11H2,1-2H3 HTSLFBUCOXVZAB-UHFFFAOYSA-N 155889 US9682966, 117::US9682966, 114::US10118915, Compound 117::US20250346584, Compound 117 Kappa-type opioid receptor Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155889&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295691 355041425 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572570 COC(=O)C1CN(CCC1NC1CCCCCC1)c1ncc(Br)cc1C(=O)OC InChI=1S/C21H30BrN3O4/c1-28-20(26)16-11-14(22)12-23-19(16)25-10-9-18(17(13-25)21(27)29-2)24-15-7-5-3-4-6-8-15/h11-12,15,17-18,24H,3-10,13H2,1-2H3 VULJZMBKLAPCJM-UHFFFAOYSA-N 155890 US9682966, 118::US9682966, 115::US10118915, Compound 118::US20250346584, Compound 118 Kappa-type opioid receptor Homo sapiens 1700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155890&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295859 355041426 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572571 COC(=O)C1CN(CCC1NC1CCCCC1)c1ncc(Br)cc1C(=O)OC InChI=1S/C20H28BrN3O4/c1-27-19(25)15-10-13(21)11-22-18(15)24-9-8-17(16(12-24)20(26)28-2)23-14-6-4-3-5-7-14/h10-11,14,16-17,23H,3-9,12H2,1-2H3 ZKCPSGKBRIBROO-UHFFFAOYSA-N 155888 US9682966, 116::US9682966, 113::US10118915, Compound 116::US20250346584, Compound 116 Kappa-type opioid receptor Homo sapiens 793 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155888&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295690 355041424 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572572 COC(=O)C1CN(CCC1NC1CCCC1)c1ncc(Br)cc1C(=O)OC InChI=1S/C19H26BrN3O4/c1-26-18(24)14-9-12(20)10-21-17(14)23-8-7-16(15(11-23)19(25)27-2)22-13-5-3-4-6-13/h9-10,13,15-16,22H,3-8,11H2,1-2H3 HTSLFBUCOXVZAB-UHFFFAOYSA-N 155889 US9682966, 117::US9682966, 114::US10118915, Compound 117::US20250346584, Compound 117 Kappa-type opioid receptor Homo sapiens 3800 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155889&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295691 355041425 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572573 COC(=O)C1CN(CCC1NC1CCCCCC1)c1ncc(Br)cc1C(=O)OC InChI=1S/C21H30BrN3O4/c1-28-20(26)16-11-14(22)12-23-19(16)25-10-9-18(17(13-25)21(27)29-2)24-15-7-5-3-4-6-8-15/h11-12,15,17-18,24H,3-10,13H2,1-2H3 VULJZMBKLAPCJM-UHFFFAOYSA-N 155890 US9682966, 118::US9682966, 115::US10118915, Compound 118::US20250346584, Compound 118 Kappa-type opioid receptor Homo sapiens 661 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155890&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295859 355041426 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572574 CCOC(=O)\C=C\c1cnc(N2CCC(CC2)NC2CCCCC2)c(c1)C(=O)OC InChI=1S/C23H33N3O4/c1-3-30-21(27)10-9-17-15-20(23(28)29-2)22(24-16-17)26-13-11-19(12-14-26)25-18-7-5-4-6-8-18/h9-10,15-16,18-19,25H,3-8,11-14H2,1-2H3 XKCKXJVDTQTFKY-UHFFFAOYSA-N 155894 US9682966, C59::US10118915, Compound C59::US20250346584, Compound C59 Kappa-type opioid receptor Homo sapiens >20000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155894&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263688 355041427 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572575 CCOC(=O)c1cc(C(=O)OC)c(C)nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C22H33N3O5/c1-4-30-22(28)17-12-16(21(27)29-3)14(2)23-20(17)25-11-10-18(19(26)13-25)24-15-8-6-5-7-9-15/h12,15,18-19,24,26H,4-11,13H2,1-3H3 QPZOVLZRMYWUBI-UHFFFAOYSA-N 155895 US9682966, 119::US10118915, Compound 119::US20250346584, Compound 119 Kappa-type opioid receptor Homo sapiens 12.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155895&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295860 355041428 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572576 N=Cc1cc(Br)cnc1N1CCC(NC2CCCCC2)C(CO)C1 785602 US20250346584, Compound 120 Kappa-type opioid receptor Homo sapiens 16.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785602 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785602&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572577 N=Cc1cc(Br)cnc1N1CCC(NC2CCCCC2)C(CO)C1 785603 US20250346584, Compound 121 Kappa-type opioid receptor Homo sapiens 45.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785603&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572578 COC1CN(CCC1NC1CCCCC1)c1ncc(Br)cc1C(=O)OC InChI=1S/C19H28BrN3O3/c1-25-17-12-23(9-8-16(17)22-14-6-4-3-5-7-14)18-15(19(24)26-2)10-13(20)11-21-18/h10-11,14,16-17,22H,3-9,12H2,1-2H3 USNDYJLCUCYRAZ-UHFFFAOYSA-N 155898 US9682966, 122::US10118915, Compound 122::US20250346584, Compound 122 Kappa-type opioid receptor Homo sapiens 125 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155898&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263653 355041430 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572579 COC1CN(CCC1NC1CCCCC1)c1ncc(I)cc1C(=O)OC InChI=1S/C19H28IN3O3/c1-25-17-12-23(9-8-16(17)22-14-6-4-3-5-7-14)18-15(19(24)26-2)10-13(20)11-21-18/h10-11,14,16-17,22H,3-9,12H2,1-2H3 SWZNFBJTDAPIQL-UHFFFAOYSA-N 155899 US9682966, 123::US10118915, Compound 123::US20250346584, Compound 123 Kappa-type opioid receptor Homo sapiens 11.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155899&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295864 355041431 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572580 N=Cc1cc(Br)cnc1N1CCC(NC2CCCCC2)C(O)C1 785606 US20250346584, Compound 124 Kappa-type opioid receptor Homo sapiens 31.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785606&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572581 N=Cc1cc(Br)cnc1N1CCC(NC2CCCCC2)C(O)C1 785607 US20250346584, Compound 125 Kappa-type opioid receptor Homo sapiens 41.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785607&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572582 COC(=O)c1cc(I)cnc1N1CCC(NC2CCCCC2)C(O)C1 InChI=1S/C18H26IN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-15(16(23)11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 URRBLZISABMGSA-UHFFFAOYSA-N 155902 US9682966, 126::US10118915, Compound 126::US20250346584, Compound 126 Kappa-type opioid receptor Homo sapiens 112 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155902&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73295012 355041433 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572583 CC(=O)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C18H26BrN3O2/c1-12(23)15-9-13(19)10-20-18(15)22-8-7-16(17(24)11-22)21-14-5-3-2-4-6-14/h9-10,14,16-17,21,24H,2-8,11H2,1H3 MFCYOQGAGIMECE-UHFFFAOYSA-N 155903 US9682966, 127::US10118915, Compound 127::US20250346584, Compound 127 Kappa-type opioid receptor Homo sapiens 33.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155903&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263691 355041434 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572584 COC(=O)c1cc(C)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C19H29N3O3/c1-13-10-15(19(24)25-2)18(20-11-13)22-9-8-16(17(23)12-22)21-14-6-4-3-5-7-14/h10-11,14,16-17,21,23H,3-9,12H2,1-2H3 DSOAWSJNPHFMRE-UHFFFAOYSA-N 155904 US9682966, 128::US10118915, Compound 128::US20250346584, Compound 128 Kappa-type opioid receptor Homo sapiens 35.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155904&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296028 355041435 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572585 O[C@@H]1CN(CC[C@H]1NC1CCCCC1)c1ncc(Br)cc1C=O |r| InChI=1S/C17H24BrN3O2/c18-13-8-12(11-22)17(19-9-13)21-7-6-15(16(23)10-21)20-14-4-2-1-3-5-14/h8-9,11,14-16,20,23H,1-7,10H2 FIGZEEAOVJMGHF-UHFFFAOYSA-N 155905 US9682966, 129::US10118915, Compound 129::US20250346584, Compound 129 Kappa-type opioid receptor Homo sapiens 799 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155905&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296029 355041436 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572586 CC(=N)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 785612 US20250346584, Compound 130 Kappa-type opioid receptor Homo sapiens 22.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785612 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785612&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572587 CC(=N)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 785613 US20250346584, Compound 131 Kappa-type opioid receptor Homo sapiens 30.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785613 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785613&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572588 COC(=O)c3cnc(N2CC[C@@H](NC1CCCCC1)[C@H](O)C2)c(Br)c3 785614 US20250346584, Compound 132 Kappa-type opioid receptor Homo sapiens 4000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785614&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572589 CCc1cnc(N2CCC(NC3CCCCC3)C(O)C2)c(c1)C(=O)OC |w:9.9,17.18| InChI=1S/C20H31N3O3/c1-3-14-11-16(20(25)26-2)19(21-12-14)23-10-9-17(18(24)13-23)22-15-7-5-4-6-8-15/h11-12,15,17-18,22,24H,3-10,13H2,1-2H3 RMQOFUZYZMOGOE-UHFFFAOYSA-N 155909 US9682966, 133::US10118915, Compound 133::US20250346584, Compound 133 Kappa-type opioid receptor Homo sapiens 272 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155909&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263693 355041439 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572590 CCOC(=O)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C19H28BrN3O3/c1-2-26-19(25)15-10-13(20)11-21-18(15)23-9-8-16(17(24)12-23)22-14-6-4-3-5-7-14/h10-11,14,16-17,22,24H,2-9,12H2,1H3 OWMUORWJDKVTEO-UHFFFAOYSA-N 155910 US9682966, 134::US10118915, Compound 134::US20250346584, Compound 134 Kappa-type opioid receptor Homo sapiens 23.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155910&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263694 355041440 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572591 CC(=O)c1cc(C)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C19H29N3O2/c1-13-10-16(14(2)23)19(20-11-13)22-9-8-17(18(24)12-22)21-15-6-4-3-5-7-15/h10-11,15,17-18,21,24H,3-9,12H2,1-2H3 MAODIHXMTXNPGE-UHFFFAOYSA-N 155911 US9682966, C60::US10118915, Compound C60::US20250346584, Compound C60 Kappa-type opioid receptor Homo sapiens 14000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155911&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263695 355041441 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572592 CC(C)OC(=O)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C20H30BrN3O3/c1-13(2)27-20(26)16-10-14(21)11-22-19(16)24-9-8-17(18(25)12-24)23-15-6-4-3-5-7-15/h10-11,13,15,17-18,23,25H,3-9,12H2,1-2H3 HJLHLHBXIPAUCJ-UHFFFAOYSA-N 155912 US9682966, 135::US10118915, Compound 135::US20250346584, Compound 135 Kappa-type opioid receptor Homo sapiens 1630 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155912&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263697 355041442 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572593 Cc1noc(n1)-c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C19H26BrN5O2/c1-12-22-19(27-24-12)15-9-13(20)10-21-18(15)25-8-7-16(17(26)11-25)23-14-5-3-2-4-6-14/h9-10,14,16-17,23,26H,2-8,11H2,1H3 KUEZBEFYEFTPMZ-UHFFFAOYSA-N 155913 US9682966, 136::US10118915, Compound 136::US20250346584, Compound 136 Kappa-type opioid receptor Homo sapiens 49.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155913&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263698 355041443 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572594 CCc1noc(n1)-c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C20H28BrN5O2/c1-2-18-24-20(28-25-18)15-10-13(21)11-22-19(15)26-9-8-16(17(27)12-26)23-14-6-4-3-5-7-14/h10-11,14,16-17,23,27H,2-9,12H2,1H3 QLZOWKYXONSWRP-UHFFFAOYSA-N 155914 US9682966, 137::US10118915, Compound 137::US20250346584, Compound 137 Kappa-type opioid receptor Homo sapiens 1600 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155914&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263699 355041444 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572595 CN(C)C(=O)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C19H29BrN4O2/c1-23(2)19(26)15-10-13(20)11-21-18(15)24-9-8-16(17(25)12-24)22-14-6-4-3-5-7-14/h10-11,14,16-17,22,25H,3-9,12H2,1-2H3 RHLMBYTWWLCHTG-UHFFFAOYSA-N 155915 US9682966, 138::US10118915, Compound 138::US20250346584, Compound 138 Kappa-type opioid receptor Homo sapiens 3200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155915&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263702 355041445 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572596 CCN(CC)C(=O)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C21H33BrN4O2/c1-3-25(4-2)21(28)17-12-15(22)13-23-20(17)26-11-10-18(19(27)14-26)24-16-8-6-5-7-9-16/h12-13,16,18-19,24,27H,3-11,14H2,1-2H3 OHOUNBUVYVCBOZ-UHFFFAOYSA-N 155916 US9682966, 139::US10118915, Compound 139::US20250346584, Compound 139 Kappa-type opioid receptor Homo sapiens 4800 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155916&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263701 355041446 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572597 Cc1noc(n1)-c1cc(C)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C20H29N5O2/c1-13-10-16(20-22-14(2)24-27-20)19(21-11-13)25-9-8-17(18(26)12-25)23-15-6-4-3-5-7-15/h10-11,15,17-18,23,26H,3-9,12H2,1-2H3 GAFFUWMMWKYJFF-UHFFFAOYSA-N 155917 US9682966, 140::US10118915, Compound 140::US20250346584, Compound 140 Kappa-type opioid receptor Homo sapiens 54.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155917&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263700 355041447 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572598 CC(=N)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 785624 US20250346584, Compound 141 Kappa-type opioid receptor Homo sapiens 107 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785624 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785624&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572599 CC(=N)c1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 785625 US20250346584, Compound 142 Kappa-type opioid receptor Homo sapiens 125 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785625 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785625&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572600 COC1CN(CCC1NC1CCCCC1)c1ncc(Br)cc1-c1nc(C)no1 InChI=1S/C20H28BrN5O2/c1-13-23-20(28-25-13)16-10-14(21)11-22-19(16)26-9-8-17(18(12-26)27-2)24-15-6-4-3-5-7-15/h10-11,15,17-18,24H,3-9,12H2,1-2H3 QBSVODHWGBIRMT-UHFFFAOYSA-N 155920 US9682966, 143::US10118915, Compound 143::US20250346584, Compound 143 Kappa-type opioid receptor Homo sapiens 100.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155920&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263703 355041448 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572601 CC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C19H28BrN3O2/c1-13(25)17-9-15(20)10-21-19(17)23-8-7-18(14(11-23)12-24)22-16-5-3-2-4-6-16/h9-10,14,16,18,22,24H,2-8,11-12H2,1H3 CIEWZDCRJWZZSY-UHFFFAOYSA-N 155863 US9682966, 144::US9682966, 97::US10118915, Compound 144::US20250346584, Compound 144 Kappa-type opioid receptor Homo sapiens 4800 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155863&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263667 355041400 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572602 COC1CN(CCC1NC1CCCCC1)c1ncc(Br)cc1C(C)=O InChI=1S/C19H28BrN3O2/c1-13(24)16-10-14(20)11-21-19(16)23-9-8-17(18(12-23)25-2)22-15-6-4-3-5-7-15/h10-11,15,17-18,22H,3-9,12H2,1-2H3 BPFBLMPLKJILQI-UHFFFAOYSA-N 155931 US9682966, C61::US10118915, Compound C61::US20250346584, Compound C61 Kappa-type opioid receptor Homo sapiens 10000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155931 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155931&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263704 355041449 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572603 Cc1noc(n1)-c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C20H28BrN5O2/c1-13-23-20(28-25-13)17-9-15(21)10-22-19(17)26-8-7-18(14(11-26)12-27)24-16-5-3-2-4-6-16/h9-10,14,16,18,24,27H,2-8,11-12H2,1H3 CMYFRGOYYFXCDO-UHFFFAOYSA-N 155932 US9682966, 145::US10118915, Compound 145::US20250346584, Compound 145 Kappa-type opioid receptor Homo sapiens 117 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155932 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155932&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263705 355041450 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572604 CCOC(=O)c1cc(Br)cnc1N1CCC(NC2CCCCC2)C(C1)OC InChI=1S/C20H30BrN3O3/c1-3-27-20(25)16-11-14(21)12-22-19(16)24-10-9-17(18(13-24)26-2)23-15-7-5-4-6-8-15/h11-12,15,17-18,23H,3-10,13H2,1-2H3 PGXITKMJSSMUDS-UHFFFAOYSA-N 155933 US9682966, 146::US10118915, Compound 146::US20250346584, Compound 146 Kappa-type opioid receptor Homo sapiens 85.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155933&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263706 355041451 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572605 N=Cc1cc(Br)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 785631 US20250346584, Compound 147 Kappa-type opioid receptor Homo sapiens 206 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785631 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785631&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572606 COC(=O)c1cccnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C18H27N3O3/c1-24-18(23)14-8-5-10-19-17(14)21-11-9-15(16(22)12-21)20-13-6-3-2-4-7-13/h5,8,10,13,15-16,20,22H,2-4,6-7,9,11-12H2,1H3 AJNIGLAHOWKSPB-UHFFFAOYSA-N 155936 US9682966, 148::US10118915, Compound 148::US20250346584, Compound 148 Kappa-type opioid receptor Homo sapiens 5800 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155936&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263708 355041453 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572607 COC(=O)c1cccnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C19H29N3O3/c1-25-19(24)16-8-5-10-20-18(16)22-11-9-17(14(12-22)13-23)21-15-6-3-2-4-7-15/h5,8,10,14-15,17,21,23H,2-4,6-7,9,11-13H2,1H3 MLCJCFNSCWDGMR-UHFFFAOYSA-N 155938 US9682966, 149::US10118915, Compound 149::US20250346584, Compound 149 Kappa-type opioid receptor Homo sapiens 5400 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155938&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263711 355041454 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572608 O[C@@H]1CN(CC[C@H]1NC1CCCCC1)c1ncc(Br)cc1-c1nc(no1)C1CC1 |r| InChI=1S/C21H28BrN5O2/c22-14-10-16(21-25-19(26-29-21)13-6-7-13)20(23-11-14)27-9-8-17(18(28)12-27)24-15-4-2-1-3-5-15/h10-11,13,15,17-18,24,28H,1-9,12H2 YSKKCFNBDHYNFQ-UHFFFAOYSA-N 155939 US9682966, 150::US10118915, Compound 150::US20250346584, Compound 150 Kappa-type opioid receptor Homo sapiens 9100 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155939&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263709 355041455 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572609 OCC1CN(CCC1NC1CCCCC1)c1ncc(Br)cc1-c1nc(no1)C1CC1 InChI=1S/C22H30BrN5O2/c23-16-10-18(22-26-20(27-30-22)14-6-7-14)21(24-11-16)28-9-8-19(15(12-28)13-29)25-17-4-2-1-3-5-17/h10-11,14-15,17,19,25,29H,1-9,12-13H2 ROJLAWMEOQYHDW-UHFFFAOYSA-N 155940 US9682966, 151::US10118915, Compound 151::US20250346584, Compound 151 Kappa-type opioid receptor Homo sapiens 2100 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155940&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263710 355041456 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572610 Cc1noc(n1)-c1cc(C)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C21H31N5O2/c1-14-10-18(21-23-15(2)25-28-21)20(22-11-14)26-9-8-19(16(12-26)13-27)24-17-6-4-3-5-7-17/h10-11,16-17,19,24,27H,3-9,12-13H2,1-2H3 IZEZEWQRIAYRJJ-UHFFFAOYSA-N 155941 US9682966, 152::US10118915, Compound 152::US20250346584, Compound 152 Kappa-type opioid receptor Homo sapiens 30.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155941&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263712 355041457 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572611 CCOC(=O)c1cc(C)c(C)nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C21H33N3O3/c1-4-27-21(26)17-12-14(2)15(3)22-20(17)24-11-10-18(19(25)13-24)23-16-8-6-5-7-9-16/h12,16,18-19,23,25H,4-11,13H2,1-3H3 FZVRGFOHKDFRBG-UHFFFAOYSA-N 155942 US9682966, 153::US10118915, Compound 153::US20250346584, Compound 153 Kappa-type opioid receptor Homo sapiens 191 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155942&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263713 355041458 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572612 Cc1noc(n1)-c1cc(C)c(C)nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C21H31N5O2/c1-13-11-17(21-23-15(3)25-28-21)20(22-14(13)2)26-10-9-18(19(27)12-26)24-16-7-5-4-6-8-16/h11,16,18-19,24,27H,4-10,12H2,1-3H3 HRMRYKMHWNEXQL-UHFFFAOYSA-N 155944 US9682966, 154::US10118915, Compound 154::US20250346584, Compound 154 Kappa-type opioid receptor Homo sapiens 146 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155944&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263720 355041459 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572613 Cc1noc(n1)-c1cc(cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1)C1CC1 |r| InChI=1S/C22H31N5O2/c1-14-24-22(29-26-14)18-11-16(15-7-8-15)12-23-21(18)27-10-9-19(20(28)13-27)25-17-5-3-2-4-6-17/h11-12,15,17,19-20,25,28H,2-10,13H2,1H3 MMTRNQRKXNCIKL-UHFFFAOYSA-N 155945 US9682966, 155::US10118915, Compound 155::US20250346584, Compound 155 Kappa-type opioid receptor Homo sapiens 1300 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155945&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263718 355041460 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572614 COC(=O)c1cc(cnc1N1CCC(NC2CCCCC2)C(O)C1)C1CC1 |w:13.14,21.23| InChI=1S/C21H31N3O3/c1-27-21(26)17-11-15(14-7-8-14)12-22-20(17)24-10-9-18(19(25)13-24)23-16-5-3-2-4-6-16/h11-12,14,16,18-19,23,25H,2-10,13H2,1H3 SKVQKBWTSBJGIY-UHFFFAOYSA-N 155946 US9682966, C66::US10118915, Compound C66::US20250346584, Compound C66 Kappa-type opioid receptor Homo sapiens 17000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155946&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263721 355041461 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572615 CCc1cnc(N2CC[C@@H](NC3CCCCC3)[C@H](O)C2)c(c1)-c1nc(C)no1 |r| InChI=1S/C21H31N5O2/c1-3-15-11-17(21-23-14(2)25-28-21)20(22-12-15)26-10-9-18(19(27)13-26)24-16-7-5-4-6-8-16/h11-12,16,18-19,24,27H,3-10,13H2,1-2H3 INPGTSNPQMKPKJ-UHFFFAOYSA-N 155948 US9682966, 156::US10118915, Compound 156::US20250346584, Compound 156 Kappa-type opioid receptor Homo sapiens 1000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155948&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263719 355041462 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572616 COC(=O)c1cc2ccccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C23H31N3O3/c1-29-23(28)19-13-16-7-5-6-10-20(16)25-22(19)26-12-11-21(17(14-26)15-27)24-18-8-3-2-4-9-18/h5-7,10,13,17-18,21,24,27H,2-4,8-9,11-12,14-15H2,1H3 RXOOWSCJGSEBJQ-UHFFFAOYSA-N 155949 US9682966, 157::US10118915, Compound 157::US20250346584, Compound 157 Kappa-type opioid receptor Homo sapiens 37.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155949&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263726 355041463 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572617 COC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1C(=O)OC InChI=1S/C23H31N3O3/c1-28-21-15-26(13-12-20(21)24-17-9-4-3-5-10-17)22-18(23(27)29-2)14-16-8-6-7-11-19(16)25-22/h6-8,11,14,17,20-21,24H,3-5,9-10,12-13,15H2,1-2H3 HAUGLWGNVCAGLQ-UHFFFAOYSA-N 155956 US9682966, 158::US10118915, Compound 158::US20250346584, Compound 158 Kappa-type opioid receptor Homo sapiens 431 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155956&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263728 355041464 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572618 CCOC(=O)c1cc(C)c(C)nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C22H35N3O3/c1-4-28-22(27)19-12-15(2)16(3)23-21(19)25-11-10-20(17(13-25)14-26)24-18-8-6-5-7-9-18/h12,17-18,20,24,26H,4-11,13-14H2,1-3H3 GDKBFOSCNLSMLN-UHFFFAOYSA-N 155957 US9682966, 159::US10118915, Compound 159::US20250346584, Compound 159 Kappa-type opioid receptor Homo sapiens 35.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155957&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263724 355041465 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572619 COC(=O)c1cc2ccccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C22H29N3O3/c1-28-22(27)17-13-15-7-5-6-10-18(15)24-21(17)25-12-11-19(20(26)14-25)23-16-8-3-2-4-9-16/h5-7,10,13,16,19-20,23,26H,2-4,8-9,11-12,14H2,1H3 UXKTZGHFQFZEBT-UHFFFAOYSA-N 155960 US9682966, 160::US10118915, Compound 160::US20250346584, Compound 160 Kappa-type opioid receptor Homo sapiens 209 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155960&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263722 355041466 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572620 COC(=O)c1cc(C)c(C)nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C20H31N3O3/c1-13-11-16(20(25)26-3)19(21-14(13)2)23-10-9-17(18(24)12-23)22-15-7-5-4-6-8-15/h11,15,17-18,22,24H,4-10,12H2,1-3H3 ZXHGLPRBDCTLJR-UHFFFAOYSA-N 155963 US9682966, 161::US10118915, Compound 161::US20250346584, Compound 161 Kappa-type opioid receptor Homo sapiens 157 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155963&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263729 355041467 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572621 COC(=O)c1cc(C)c(C)nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C21H33N3O3/c1-14-11-18(21(26)27-3)20(22-15(14)2)24-10-9-19(16(12-24)13-25)23-17-7-5-4-6-8-17/h11,16-17,19,23,25H,4-10,12-13H2,1-3H3 KHVODFUQBWFJGD-UHFFFAOYSA-N 155965 US9682966, 162::US10118915, Compound 162::US20250346584, Compound 162 Kappa-type opioid receptor Homo sapiens 1400 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155965&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263723 355041468 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572622 COC1CN(CCC1NC1CCCCC1)c1nc(C)c(C)cc1C(=O)OC InChI=1S/C21H33N3O3/c1-14-12-17(21(25)27-4)20(22-15(14)2)24-11-10-18(19(13-24)26-3)23-16-8-6-5-7-9-16/h12,16,18-19,23H,5-11,13H2,1-4H3 CLTOBZGIRFHYEL-UHFFFAOYSA-N 155967 US9682966, 163::US10118915, Compound 163::US20250346584, Compound 163 Kappa-type opioid receptor Homo sapiens 915 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155967&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263733 355041469 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572623 Cc1noc(n1)-c1cc(C)c(C)nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C22H33N5O2/c1-14-11-19(22-24-16(3)26-29-22)21(23-15(14)2)27-10-9-20(17(12-27)13-28)25-18-7-5-4-6-8-18/h11,17-18,20,25,28H,4-10,12-13H2,1-3H3 YNTWEEMQRIJVFY-UHFFFAOYSA-N 155980 US9682966, 164::US10118915, Compound 164::US20250346584, Compound 164 Kappa-type opioid receptor Homo sapiens 62.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155980&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263725 355041470 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572625 COC(=O)\C(\C=C(\C)N)=C(\N)N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C18H32N4O3/c1-12(19)10-14(18(24)25-2)17(20)22-9-8-15(16(23)11-22)21-13-6-4-3-5-7-13/h10,13,15-16,21,23H,3-9,11,19-20H2,1-2H3 ATWDJNCTZAEGCQ-UHFFFAOYSA-N 156015 US9682966, 166::US20250346584, Compound 166 Kappa-type opioid receptor Homo sapiens 32.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156015&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263734 355041472 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572626 COC1CN(CCC1NC1CCCCC1)C(\N)=C(\C=C(\C)N)/C(=O)OC InChI=1S/C19H34N4O3/c1-13(20)11-15(19(24)26-3)18(21)23-10-9-16(17(12-23)25-2)22-14-7-5-4-6-8-14/h11,14,16-17,22H,4-10,12,20-21H2,1-3H3 UDBAGWZWEMNCBR-UHFFFAOYSA-N 156022 US9682966, 167::US20250346584, Compound 167 Kappa-type opioid receptor Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156022&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263735 355041473 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572627 CCc1noc(n1)-c1cc(C)cnc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C21H31N5O2/c1-3-19-24-21(28-25-19)16-11-14(2)12-22-20(16)26-10-9-17(18(27)13-26)23-15-7-5-4-6-8-15/h11-12,15,17-18,23,27H,3-10,13H2,1-2H3 PXZJEUSSBVLYJW-UHFFFAOYSA-N 156030 US9682966, 168::US10118915, Compound 168::US20250346584, Compound 168 Kappa-type opioid receptor Homo sapiens 7000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156030&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263727 355041474 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572628 Cc1cnc(N2CC[C@@H](NC3CCCCC3)[C@H](O)C2)c(c1)-c1ncco1 |r| InChI=1S/C20H28N4O2/c1-14-11-16(20-21-8-10-26-20)19(22-12-14)24-9-7-17(18(25)13-24)23-15-5-3-2-4-6-15/h8,10-12,15,17-18,23,25H,2-7,9,13H2,1H3 RIMIMXDEZHMZLR-UHFFFAOYSA-N 156034 US9682966, 169::US10118915, Compound 169::US20250346584, Compound 169 Kappa-type opioid receptor Homo sapiens 2500 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156034&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263736 355041475 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572629 COC(=O)\C(\C=C(\C)N)=C(\N)N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C19H34N4O3/c1-13(20)10-16(19(25)26-2)18(21)23-9-8-17(14(11-23)12-24)22-15-6-4-3-5-7-15/h10,14-15,17,22,24H,3-9,11-12,20-21H2,1-2H3 OQSZVMGXERCDKT-UHFFFAOYSA-N 156062 US9682966, 170::US20250346584, Compound 170 Kappa-type opioid receptor Homo sapiens 11.7 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156062&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263730 355041476 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572630 CCc1noc(n1)-c1cc(C)cnc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C22H33N5O2/c1-3-20-25-22(29-26-20)18-11-15(2)12-23-21(18)27-10-9-19(16(13-27)14-28)24-17-7-5-4-6-8-17/h11-12,16-17,19,24,28H,3-10,13-14H2,1-2H3 XZLDSSNRNSHLFC-UHFFFAOYSA-N 156096 US9682966, 171::US10118915, Compound 171::US20250346584, Compound 171 Kappa-type opioid receptor Homo sapiens 1100 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156096&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263739 355041477 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572631 Cc1noc(n1)-c1cc2ccccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C23H29N5O2/c1-15-24-23(30-27-15)18-13-16-7-5-6-10-19(16)26-22(18)28-12-11-20(21(29)14-28)25-17-8-3-2-4-9-17/h5-7,10,13,17,20-21,25,29H,2-4,8-9,11-12,14H2,1H3 ZEVXCISVDYWUIE-UHFFFAOYSA-N 156108 US9682966, 172::US10118915, Compound 172::US20250346584, Compound 192 Kappa-type opioid receptor Homo sapiens 22.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156108&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263745 355041478 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572632 Cc1noc(-c2cc(C(F)(F)F)cnc2N2CCC(NC3CCCCC3)C(O)C2)n1 785658 US20250346584, Compound 173 Kappa-type opioid receptor Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785658 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785658&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572633 COC1CN(CCC1NC1CCCCC1)c1ncc(cc1-c1nc(C)no1)C(F)(F)F InChI=1S/C21H28F3N5O2/c1-13-26-20(31-28-13)16-10-14(21(22,23)24)11-25-19(16)29-9-8-17(18(12-29)30-2)27-15-6-4-3-5-7-15/h10-11,15,17-18,27H,3-9,12H2,1-2H3 CCQFUQYNXOELML-UHFFFAOYSA-N 156122 US9682966, 174::US10118915, Compound 174::US20250346584, Compound 174 Kappa-type opioid receptor Homo sapiens 180 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156122&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296031 355041480 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572634 C\C(N)=C\C(=C(/N)N1CC[C@@H](NC2CCCCC2)[C@H](O)C1)\c1nc(C)no1 |r| InChI=1S/C19H32N6O2/c1-12(20)10-15(19-22-13(2)24-27-19)18(21)25-9-8-16(17(26)11-25)23-14-6-4-3-5-7-14/h10,14,16-17,23,26H,3-9,11,20-21H2,1-2H3 VPWNNXHBQAUGQE-UHFFFAOYSA-N 156125 US9682966, 175::US20250346584, Compound 175 Kappa-type opioid receptor Homo sapiens 46.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156125&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263731 355041481 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572635 Cc1cnc(N2CC[C@@H](NC3CCCCC3)[C@H](O)C2)c(c1)C#N |r| InChI=1S/C18H26N4O/c1-13-9-14(10-19)18(20-11-13)22-8-7-16(17(23)12-22)21-15-5-3-2-4-6-15/h9,11,15-17,21,23H,2-8,12H2,1H3 BWZAJXKZXYLBMA-UHFFFAOYSA-N 156127 US9682966, C67::US10118915, Compound C67::US20250346584, Compound C67 Kappa-type opioid receptor Homo sapiens 37000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156127&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263737 355041482 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572636 Cc1cnc(N2CCC(NC3CCCCC3)C(CO)C2)c(c1)C#N InChI=1S/C19H28N4O/c1-14-9-15(10-20)19(21-11-14)23-8-7-18(16(12-23)13-24)22-17-5-3-2-4-6-17/h9,11,16-18,22,24H,2-8,12-13H2,1H3 KODLGFMZCDRIEE-UHFFFAOYSA-N 156128 US9682966, C68::US10118915, Compound C68::US20250346584, Compound C68 Kappa-type opioid receptor Homo sapiens >20000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156128&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263732 355041483 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572637 COC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1-c1nc(C)no1 InChI=1S/C24H31N5O2/c1-16-25-24(31-28-16)19-14-17-8-6-7-11-20(17)27-23(19)29-13-12-21(22(15-29)30-2)26-18-9-4-3-5-10-18/h6-8,11,14,18,21-22,26H,3-5,9-10,12-13,15H2,1-2H3 LYPIJTFCQSRMIO-UHFFFAOYSA-N 156131 US9682966, 292::US9682966, 176::US10118915, Compound 292::US20250346584, Compound 292 Kappa-type opioid receptor Homo sapiens 28.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156131&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296191 355041484 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572638 CC(=N)\N=C(/O)c1cnc(N2CC[C@@H](NC3CCCCC3)[C@H](O)C2)c(C)c1 |r| InChI=1S/C20H31N5O2/c1-13-10-15(20(27)23-14(2)21)11-22-19(13)25-9-8-17(18(26)12-25)24-16-6-4-3-5-7-16/h10-11,16-18,24,26H,3-9,12H2,1-2H3,(H2,21,23,27) BBLXLQPBWDZMPX-UHFFFAOYSA-N 156142 US9682966, 177::US20250346584, Compound 177 Kappa-type opioid receptor Homo sapiens >20.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156142&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263746 355041485 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572640 COC1CN(CCC1NC1CCCCC1)c1ncc(C)cc1-c1nc(C)no1 InChI=1S/C21H31N5O2/c1-14-11-17(21-23-15(2)25-28-21)20(22-12-14)26-10-9-18(19(13-26)27-3)24-16-7-5-4-6-8-16/h11-12,16,18-19,24H,4-10,13H2,1-3H3 KPFOVAJOPSVOTB-UHFFFAOYSA-N 156159 US9682966, 179::US10118915, Compound 179::US20250346584, Compound 179 Kappa-type opioid receptor Homo sapiens 253 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156159&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263738 355041486 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572641 C\C(N)=C\C(=C(/N)N1CCC(NC2CCCCC2)C(CO)C1)\c1nc(C)no1 InChI=1S/C20H34N6O2/c1-13(21)10-17(20-23-14(2)25-28-20)19(22)26-9-8-18(15(11-26)12-27)24-16-6-4-3-5-7-16/h10,15-16,18,24,27H,3-9,11-12,21-22H2,1-2H3 RKMHQDYEWATBPR-UHFFFAOYSA-N 156162 US9682966, 180::US20250346584, Compound 180 Kappa-type opioid receptor Homo sapiens 7.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156162 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156162&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263740 355041487 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572642 COC1CN(CCC1NC1CCCCC1)C(\N)=C(\C=C(\C)N)/c1nc(C)no1 InChI=1S/C20H34N6O2/c1-13(21)11-16(20-23-14(2)25-28-20)19(22)26-10-9-17(18(12-26)27-3)24-15-7-5-4-6-8-15/h11,15,17-18,24H,4-10,12,21-22H2,1-3H3 CVETVIQDECOYEO-UHFFFAOYSA-N 156164 US9682966, 181::US20250346584, Compound 181 Kappa-type opioid receptor Homo sapiens 30.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156164&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263742 355041488 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572643 CCC1(CO)CN(CCC1NC1CCCCC1)c1ncc(C)cc1-c1nc(C)no1 InChI=1S/C23H35N5O2/c1-4-23(15-29)14-28(11-10-20(23)26-18-8-6-5-7-9-18)21-19(12-16(2)13-24-21)22-25-17(3)27-30-22/h12-13,18,20,26,29H,4-11,14-15H2,1-3H3 LQOGVENJRKKPIQ-UHFFFAOYSA-N 156166 US9682966, 182::US10118915, Compound 182::US20250346584, Compound 182 Kappa-type opioid receptor Homo sapiens 76.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156166 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156166&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296193 355041489 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572644 CCC1CN(CCC1NC1CCCCC1)c1ncc(C)cc1-c1nc(C)no1 |w:7.8,2.1| InChI=1S/C22H33N5O/c1-4-17-14-27(11-10-20(17)25-18-8-6-5-7-9-18)21-19(12-15(2)13-23-21)22-24-16(3)26-28-22/h12-13,17-18,20,25H,4-11,14H2,1-3H3 NUHLCHDZKZEQFT-UHFFFAOYSA-N 156173 US9682966, 183::US10118915, Compound 183::US20250346584, Compound 183 Kappa-type opioid receptor Homo sapiens 280 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156173 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156173&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296195 355041490 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572645 CCC1(CO)CN(CCC1NC1CCCCC1)C(\N)=C(\C=C(\C)N)/c1nc(C)no1 InChI=1S/C22H38N6O2/c1-4-22(14-29)13-28(11-10-19(22)26-17-8-6-5-7-9-17)20(24)18(12-15(2)23)21-25-16(3)27-30-21/h12,17,19,26,29H,4-11,13-14,23-24H2,1-3H3 LZWSMHNQMCQRQF-UHFFFAOYSA-N 156174 US9682966, 184::US20250346584, Compound 184 Kappa-type opioid receptor Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156174&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263743 355041491 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572646 CCC1CN(CCC1NC1CCCCC1)C(\N)=C(\C=C(\C)N)/c1nc(C)no1 |w:7.8,2.1| InChI=1S/C21H36N6O/c1-4-16-13-27(11-10-19(16)25-17-8-6-5-7-9-17)20(23)18(12-14(2)22)21-24-15(3)26-28-21/h12,16-17,19,25H,4-11,13,22-23H2,1-3H3 AXLNKQWFFGVPMF-UHFFFAOYSA-N 156176 US9682966, 185::US20250346584, Compound 185 Kappa-type opioid receptor Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156176&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263741 355041492 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572647 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C24H31N5O2/c1-16-25-24(31-28-16)20-13-17-7-5-6-10-21(17)27-23(20)29-12-11-22(18(14-29)15-30)26-19-8-3-2-4-9-19/h5-7,10,13,18-19,22,26,30H,2-4,8-9,11-12,14-15H2,1H3 LZESDAZIEDKXTA-UHFFFAOYSA-N 156178 US9682966, 186::US10118915, Compound 186::US20250346584, Compound 186 Kappa-type opioid receptor Homo sapiens 5.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156178&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263744 355041493 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572648 Cc1noc(n1)-c1cc(cnc1N1CCC(NC2CCCCC2)C(CO)C1)C(F)(F)F InChI=1S/C21H28F3N5O2/c1-13-26-20(31-28-13)17-9-15(21(22,23)24)10-25-19(17)29-8-7-18(14(11-29)12-30)27-16-5-3-2-4-6-16/h9-10,14,16,18,27,30H,2-8,11-12H2,1H3 SUYUFLMYGPXBBC-UHFFFAOYSA-N 156179 US9682966, 187::US10118915, Compound 187::US20250346584, Compound 187 Kappa-type opioid receptor Homo sapiens 341 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156179&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118267214 355041494 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572649 Cc1noc(n1)-c1nc2ccccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C22H28N6O2/c1-14-23-22(30-27-14)20-21(26-17-10-6-5-9-16(17)25-20)28-12-11-18(19(29)13-28)24-15-7-3-2-4-8-15/h5-6,9-10,15,18-19,24,29H,2-4,7-8,11-13H2,1H3 WPRFELTXGZIZFP-UHFFFAOYSA-N 156181 US9682966, 188::US10118915, Compound 188::US20250346584, Compound 188 Kappa-type opioid receptor Homo sapiens 187 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156181&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296488 355041495 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572650 Cc1noc(n1)-c1nc2ccccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C23H30N6O2/c1-15-24-23(31-28-15)21-22(27-20-10-6-5-9-19(20)26-21)29-12-11-18(16(13-29)14-30)25-17-7-3-2-4-8-17/h5-6,9-10,16-18,25,30H,2-4,7-8,11-14H2,1H3 FDHPKHPJVMUTHC-UHFFFAOYSA-N 156188 US9682966, 189::US10118915, Compound 189::US20250346584, Compound 189 Kappa-type opioid receptor Homo sapiens 125 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156188&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296342 355041496 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572651 COC1CN(CCC1NC1CCCCC1)c1nc2ccccc2nc1-c1nc(C)no1 InChI=1S/C23H30N6O2/c1-15-24-23(31-28-15)21-22(27-18-11-7-6-10-17(18)26-21)29-13-12-19(20(14-29)30-2)25-16-8-4-3-5-9-16/h6-7,10-11,16,19-20,25H,3-5,8-9,12-14H2,1-2H3 DEGYWVUDLYCWEF-UHFFFAOYSA-N 156191 US9682966, 190::US10118915, Compound 190::US20250346584, Compound 190 Kappa-type opioid receptor Homo sapiens 57.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156191&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296343 355041497 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572652 Cc1noc(n1)-c1cc2CCCCc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C24H35N5O2/c1-16-25-24(31-28-16)20-13-17-7-5-6-10-21(17)27-23(20)29-12-11-22(18(14-29)15-30)26-19-8-3-2-4-9-19/h13,18-19,22,26,30H,2-12,14-15H2,1H3 WWGJITFHXOPVNE-UHFFFAOYSA-N 156193 US9682966, 191::US10118915, Compound 191::US20250346584, Compound 191 Kappa-type opioid receptor Homo sapiens 420 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156193&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263752 355041498 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572653 Cc1noc(n1)-c1cc2ccccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C23H29N5O2/c1-15-24-23(30-27-15)18-13-16-7-5-6-10-19(16)26-22(18)28-12-11-20(21(29)14-28)25-17-8-3-2-4-9-17/h5-7,10,13,17,20-21,25,29H,2-4,8-9,11-12,14H2,1H3 ZEVXCISVDYWUIE-UHFFFAOYSA-N 156108 US9682966, 172::US10118915, Compound 172::US20250346584, Compound 192 Kappa-type opioid receptor Homo sapiens 199 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156108&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263745 355041478 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572654 COC1CN(CCC1NC1CCCCC1)c1nc2CCCCc2cc1-c1nc(C)no1 InChI=1S/C24H35N5O2/c1-16-25-24(31-28-16)19-14-17-8-6-7-11-20(17)27-23(19)29-13-12-21(22(15-29)30-2)26-18-9-4-3-5-10-18/h14,18,21-22,26H,3-13,15H2,1-2H3 QUSLIUGAJBCLFP-UHFFFAOYSA-N 156198 US9682966, 193::US10118915, Compound 193::US20250346584, Compound 193 Kappa-type opioid receptor Homo sapiens 729 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156198 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156198&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263748 355041500 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572655 CC1CN(CCC1NC1CCCCC1)c1ncc(C)cc1-c1nc(C)no1 |w:6.7,1.0| InChI=1S/C21H31N5O/c1-14-11-18(21-23-16(3)25-27-21)20(22-12-14)26-10-9-19(15(2)13-26)24-17-7-5-4-6-8-17/h11-12,15,17,19,24H,4-10,13H2,1-3H3 SMNDVXWURQUEMT-UHFFFAOYSA-N 156200 US9682966, 194::US10118915, Compound 194::US20250346584, Compound 194 Kappa-type opioid receptor Homo sapiens 180 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156200 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156200&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263755 355041501 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572656 Cc1noc(n1)-c1cc(C)cnc1N1CCC(NC2CCOCC2)C(CO)C1 InChI=1S/C20H29N5O3/c1-13-9-17(20-22-14(2)24-28-20)19(21-10-13)25-6-3-18(15(11-25)12-26)23-16-4-7-27-8-5-16/h9-10,15-16,18,23,26H,3-8,11-12H2,1-2H3 MCHSIEDMGIHKRM-UHFFFAOYSA-N 156201 US9682966, 195::US10118915, Compound 195::US20250346584, Compound 195 Kappa-type opioid receptor Homo sapiens 700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156201 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156201&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263763 355041502 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572657 COC1CCCCC1NC1CCN(CC1CO)c1ncc(C)cc1-c1nc(C)no1 |w:8.8,2.1| InChI=1S/C22H33N5O3/c1-14-10-17(22-24-15(2)26-30-22)21(23-11-14)27-9-8-18(16(12-27)13-28)25-19-6-4-5-7-20(19)29-3/h10-11,16,18-20,25,28H,4-9,12-13H2,1-3H3 YAXSROHWQNYRSX-UHFFFAOYSA-N 156203 US9682966, 196::US10118915, Compound 196::US20250346584, Compound 196 Kappa-type opioid receptor Homo sapiens 414 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156203&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263749 355041503 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572658 Cc1noc(n1)-c1cc(C)cnc1N1CCC(NC2CCCCCC2)C(CO)C1 InChI=1S/C22H33N5O2/c1-15-11-19(22-24-16(2)26-29-22)21(23-12-15)27-10-9-20(17(13-27)14-28)25-18-7-5-3-4-6-8-18/h11-12,17-18,20,25,28H,3-10,13-14H2,1-2H3 QKNNYKKMJGRLCI-UHFFFAOYSA-N 156207 US9682966, 197::US10118915, Compound 197::US20250346584, Compound 197 Kappa-type opioid receptor Homo sapiens 85.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156207 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156207&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263750 355041504 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572659 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(NC2CCOCC2)C(CO)C1 InChI=1S/C23H29N5O3/c1-15-24-23(31-27-15)19-12-16-4-2-3-5-20(16)26-22(19)28-9-6-21(17(13-28)14-29)25-18-7-10-30-11-8-18/h2-5,12,17-18,21,25,29H,6-11,13-14H2,1H3 IFGKNYTWHZKBST-UHFFFAOYSA-N 156208 US9682966, 198::US10118915, Compound 198::US20250346584, Compound 198 Kappa-type opioid receptor Homo sapiens 98.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156208 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156208&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296346 355041505 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572660 COC1CCCCC1NC1CCN(CC1CO)c1nc2ccccc2cc1-c1nc(C)no1 |w:8.8,2.1| InChI=1S/C25H33N5O3/c1-16-26-25(33-29-16)19-13-17-7-3-4-8-20(17)28-24(19)30-12-11-21(18(14-30)15-31)27-22-9-5-6-10-23(22)32-2/h3-4,7-8,13,18,21-23,27,31H,5-6,9-12,14-15H2,1-2H3 DRMNXJDXAXEIMU-UHFFFAOYSA-N 156209 US9682966, 199::US10118915, Compound 199::US20250346584, Compound 199 Kappa-type opioid receptor Homo sapiens 59.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156209 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156209&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263756 355041506 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572661 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(NC2CCCCCC2)C(CO)C1 InChI=1S/C25H33N5O2/c1-17-26-25(32-29-17)21-14-18-8-6-7-11-22(18)28-24(21)30-13-12-23(19(15-30)16-31)27-20-9-4-2-3-5-10-20/h6-8,11,14,19-20,23,27,31H,2-5,9-10,12-13,15-16H2,1H3 NICZAFPBZMROBD-UHFFFAOYSA-N 156210 US9682966, 200::US10118915, Compound 200::US20250346584, Compound 200 Kappa-type opioid receptor Homo sapiens 14.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156210 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156210&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263757 355041507 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572662 Cc1noc(n1)-c1cc(C)cnc1N1CCC(NC2CCCC2)C(CO)C1 InChI=1S/C20H29N5O2/c1-13-9-17(20-22-14(2)24-27-20)19(21-10-13)25-8-7-18(15(11-25)12-26)23-16-5-3-4-6-16/h9-10,15-16,18,23,26H,3-8,11-12H2,1-2H3 FSXSGWOJRPOEAK-UHFFFAOYSA-N 156211 US9682966, 201::US10118915, Compound 201::US20250346584, Compound 201 Kappa-type opioid receptor Homo sapiens 116 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156211 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156211&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263751 355041508 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572663 Cc1noc(n1)-c1nc2ccccc2nc1N1CCC(NC2CCCC2)C(CO)C1 InChI=1S/C22H28N6O2/c1-14-23-22(30-27-14)20-21(26-19-9-5-4-8-18(19)25-20)28-11-10-17(15(12-28)13-29)24-16-6-2-3-7-16/h4-5,8-9,15-17,24,29H,2-3,6-7,10-13H2,1H3 RZWRPAFKRNQRGU-UHFFFAOYSA-N 156214 US9682966, 202::US10118915, Compound 202::US20250346584, Compound 202 Kappa-type opioid receptor Homo sapiens 187 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156214&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263753 355041509 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572664 CC1CCCCC1NC1CCN(CC1CO)c1ncc(C)cc1-c1nc(C)no1 |w:7.7,1.0| InChI=1S/C22H33N5O2/c1-14-10-18(22-24-16(3)26-29-22)21(23-11-14)27-9-8-20(17(12-27)13-28)25-19-7-5-4-6-15(19)2/h10-11,15,17,19-20,25,28H,4-9,12-13H2,1-3H3 JGLWFNZYGAIHCR-UHFFFAOYSA-N 156216 US9682966, 203::US10118915, Compound 203::US20250346584, Compound 203 Kappa-type opioid receptor Homo sapiens 132 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156216&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263764 355041510 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572665 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(NC2CCCCC2)C(F)C1 |w:19.22,27.31| InChI=1S/C23H28FN5O/c1-15-25-23(30-28-15)18-13-16-7-5-6-10-20(16)27-22(18)29-12-11-21(19(24)14-29)26-17-8-3-2-4-9-17/h5-7,10,13,17,19,21,26H,2-4,8-9,11-12,14H2,1H3 IMNAAOJRMGKODW-UHFFFAOYSA-N 156218 US9682966, 204::US10118915, Compound 204::US20250346584, Compound 204 Kappa-type opioid receptor Homo sapiens 52.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156218 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156218&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263758 355041511 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572666 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(NC2CCCC2)C(CO)C1 InChI=1S/C23H29N5O2/c1-15-24-23(30-27-15)19-12-16-6-2-5-9-20(16)26-22(19)28-11-10-21(17(13-28)14-29)25-18-7-3-4-8-18/h2,5-6,9,12,17-18,21,25,29H,3-4,7-8,10-11,13-14H2,1H3 QKYKIJKDTRJEOQ-UHFFFAOYSA-N 156219 US9682966, 205::US10118915, Compound 205::US20250346584, Compound 205 Kappa-type opioid receptor Homo sapiens 17.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156219&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263759 355041512 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572667 CC1CCCCC1NC1CCN(CC1CO)c1nc2ccccc2cc1-c1nc(C)no1 |w:7.7,1.0| InChI=1S/C25H33N5O2/c1-16-7-3-5-9-21(16)27-23-11-12-30(14-19(23)15-31)24-20(25-26-17(2)29-32-25)13-18-8-4-6-10-22(18)28-24/h4,6,8,10,13,16,19,21,23,27,31H,3,5,7,9,11-12,14-15H2,1-2H3 LYBMQIPDDCSMKZ-UHFFFAOYSA-N 156220 US9682966, 206::US10118915, Compound 206::US20250346584, Compound 206 Kappa-type opioid receptor Homo sapiens 33.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156220&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263780 355041513 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572668 Cc1noc(n1)-c1cc2CCCc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C22H31N5O2/c1-14-23-22(29-26-14)17-12-15-6-5-9-18(15)25-21(17)27-11-10-19(20(28)13-27)24-16-7-3-2-4-8-16/h12,16,19-20,24,28H,2-11,13H2,1H3 FKRNBNXZLYNSHB-UHFFFAOYSA-N 297942 US10118915, Compound 207::US20250346584, Compound 207 Kappa-type opioid receptor Homo sapiens 276 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=297942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=297942&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264136 381620775 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572669 CCC1(CO)CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1-c1nc(C)no1 InChI=1S/C26H35N5O2/c1-3-26(17-32)16-31(14-13-23(26)28-20-10-5-4-6-11-20)24-21(25-27-18(2)30-33-25)15-19-9-7-8-12-22(19)29-24/h7-9,12,15,20,23,28,32H,3-6,10-11,13-14,16-17H2,1-2H3 XMYIYMIWHSGYQW-UHFFFAOYSA-N 156223 US9682966, 208::US10118915, Compound 208::US20250346584, Compound 208 Kappa-type opioid receptor Homo sapiens 76.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156223 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156223&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263797 355041515 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572670 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C23H29N5O/c1-16-24-23(29-27-16)20-15-17-7-5-6-10-21(17)26-22(20)28-13-11-19(12-14-28)25-18-8-3-2-4-9-18/h5-7,10,15,18-19,25H,2-4,8-9,11-14H2,1H3 OGHSVOJZYFNALZ-UHFFFAOYSA-N 156224 US9682966, 209::US10118915, Compound 209::US20250346584, Compound 209 Kappa-type opioid receptor Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156224&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263760 355041516 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572671 COC1CN(CCC1NC1CCCCC1)c1nc2CCCc2cc1-c1nc(C)no1 InChI=1S/C23H33N5O2/c1-15-24-23(30-27-15)18-13-16-7-6-10-19(16)26-22(18)28-12-11-20(21(14-28)29-2)25-17-8-4-3-5-9-17/h13,17,20-21,25H,3-12,14H2,1-2H3 GAXFTZVVAPVCMP-UHFFFAOYSA-N 156225 US9682966, 210::US10118915, Compound 210::US20250346584, Compound 210 Kappa-type opioid receptor Homo sapiens 72.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156225&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263784 355041517 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572672 Cc1noc(n1)-c1cc2CCCc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C23H33N5O2/c1-15-24-23(30-27-15)19-12-16-6-5-9-20(16)26-22(19)28-11-10-21(17(13-28)14-29)25-18-7-3-2-4-8-18/h12,17-18,21,25,29H,2-11,13-14H2,1H3 OJJFGVCCQFWBDF-UHFFFAOYSA-N 156226 US9682966, 211::US10118915, Compound 211::US20250346584, Compound 211 Kappa-type opioid receptor Homo sapiens 74.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156226&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263761 355041518 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572673 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(C1)NC1CCCCC1 InChI=1S/C22H27N5O/c1-15-23-22(28-26-15)19-13-16-7-5-6-10-20(16)25-21(19)27-12-11-18(14-27)24-17-8-3-2-4-9-17/h5-7,10,13,17-18,24H,2-4,8-9,11-12,14H2,1H3 LDTPYTDXDPWISM-UHFFFAOYSA-N 156227 US9682966, 212::US10118915, Compound 212::US20250346584, Compound 212 Kappa-type opioid receptor Homo sapiens 267 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156227 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156227&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263799 355041519 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572674 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C24H31N5O2/c1-15-8-9-20-17(12-15)13-19(24-25-16(2)28-31-24)23(27-20)29-11-10-21(22(30)14-29)26-18-6-4-3-5-7-18/h8-9,12-13,18,21-22,26,30H,3-7,10-11,14H2,1-2H3 PXHVLGJGTGMOFV-UHFFFAOYSA-N 156229 US9682966, 213::US10118915, Compound 213::US20250346584, Compound 213 Kappa-type opioid receptor Homo sapiens 8.50 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156229&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263754 355041520 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572675 COC1CN(CCC1NC1CCCCC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C25H33N5O2/c1-16-9-10-21-18(13-16)14-20(25-26-17(2)29-32-25)24(28-21)30-12-11-22(23(15-30)31-3)27-19-7-5-4-6-8-19/h9-10,13-14,19,22-23,27H,4-8,11-12,15H2,1-3H3 PGXSSLBJKPYNJE-UHFFFAOYSA-N 156379 US9682966, 293::US9682966, 214::US10118915, Compound 293::US20250346584, Compound 293 Kappa-type opioid receptor Homo sapiens 3.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156379&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263765 355041521 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572676 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C25H33N5O2/c1-16-8-9-22-18(12-16)13-21(25-26-17(2)29-32-25)24(28-22)30-11-10-23(19(14-30)15-31)27-20-6-4-3-5-7-20/h8-9,12-13,19-20,23,27,31H,3-7,10-11,14-15H2,1-2H3 RIWLMHGNRXTJDY-UHFFFAOYSA-N 156381 US9682966, 215::US10118915, Compound 215::US20250346584, Compound 215 Kappa-type opioid receptor Homo sapiens 3.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156381 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156381&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263800 355041522 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572677 Cc1cnc(N2CCC(NC3CCCCC3)C(CO)C2)c(C=O)c1 InChI=1S/C19H29N3O2/c1-14-9-15(12-23)19(20-10-14)22-8-7-18(16(11-22)13-24)21-17-5-3-2-4-6-17/h9-10,12,16-18,21,24H,2-8,11,13H2,1H3 UZSMKWVLWPHYRZ-UHFFFAOYSA-N 156404 US9682966, 216::US10118915, Compound 216::US20250346584, Compound 216 Kappa-type opioid receptor Homo sapiens 4500 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156404&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263766 355041523 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572678 Cc1cnc(N2CCC(NC3CCCCC3)C(CO)C2)c(c1)-c1ncco1 InChI=1S/C21H30N4O2/c1-15-11-18(21-22-8-10-27-21)20(23-12-15)25-9-7-19(16(13-25)14-26)24-17-5-3-2-4-6-17/h8,10-12,16-17,19,24,26H,2-7,9,13-14H2,1H3 XOSGIGLAWNCRRB-UHFFFAOYSA-N 156408 US9682966, 217::US10118915, Compound 217::US20250346584, Compound 217 Kappa-type opioid receptor Homo sapiens 361 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156408 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156408&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263775 355041524 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572679 O[C@@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccccc2cc1-c1ncco1 |r| InChI=1S/C23H28N4O2/c28-21-15-27(12-10-20(21)25-17-7-2-1-3-8-17)22-18(23-24-11-13-29-23)14-16-6-4-5-9-19(16)26-22/h4-6,9,11,13-14,17,20-21,25,28H,1-3,7-8,10,12,15H2 LFGUOMWNLGKCGQ-UHFFFAOYSA-N 156409 US9682966, 218::US10118915, Compound 218::US20250346584, Compound 218 Kappa-type opioid receptor Homo sapiens 475 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156409&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263776 355041525 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572680 COC1CN(CCC1NC1CCCCC1)c1ncc(C)cc1C=O InChI=1S/C19H29N3O2/c1-14-10-15(13-23)19(20-11-14)22-9-8-17(18(12-22)24-2)21-16-6-4-3-5-7-16/h10-11,13,16-18,21H,3-9,12H2,1-2H3 XNRVUAUIGRDTKL-UHFFFAOYSA-N 156417 US9682966, C69::US10118915, Compound C69::US20250346584, Compound C69 Kappa-type opioid receptor Homo sapiens 30000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156417 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156417&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263762 355041526 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572681 COC1CN(CCC1NC1CCCCC1)c1ncc(C)cc1-c1ncco1 InChI=1S/C21H30N4O2/c1-15-12-17(21-22-9-11-27-21)20(23-13-15)25-10-8-18(19(14-25)26-2)24-16-6-4-3-5-7-16/h9,11-13,16,18-19,24H,3-8,10,14H2,1-2H3 XBXCCNQEZPXMIL-UHFFFAOYSA-N 156421 US9682966, C70::US10118915, Compound C70::US20250346584, Compound C70 Kappa-type opioid receptor Homo sapiens 17000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156421&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263786 355041527 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572682 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C24H31N5O/c1-16-8-9-22-18(14-16)15-21(24-25-17(2)28-30-24)23(27-22)29-12-10-20(11-13-29)26-19-6-4-3-5-7-19/h8-9,14-15,19-20,26H,3-7,10-13H2,1-2H3 UZJLZNLPEHXTRT-UHFFFAOYSA-N 156424 US9682966, 219::US10118915, Compound 219::US20250346584, Compound 219 Kappa-type opioid receptor Homo sapiens 3.50 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156424&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263778 355041528 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572683 COC1CN(c2ncc(C)cc2C=N)CCC1NC1CCCCC1 785709 US20250346584, Compound 220 Kappa-type opioid receptor Homo sapiens 101 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785709 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785709&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572684 Cc1noc(n1)-c1cc(C)c(C)nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C21H31N5O/c1-14-13-19(21-23-16(3)25-27-21)20(22-15(14)2)26-11-9-18(10-12-26)24-17-7-5-4-6-8-17/h13,17-18,24H,4-12H2,1-3H3 ZQALMDXITAHUOK-UHFFFAOYSA-N 156426 US9682966, 221::US10118915, Compound 221::US20250346584, Compound 221 Kappa-type opioid receptor Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156426 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156426&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263779 355041530 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572685 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(CO)(CC1)NC1CCCCC1 InChI=1S/C24H31N5O2/c1-17-25-23(31-28-17)20-15-18-7-5-6-10-21(18)26-22(20)29-13-11-24(16-30,12-14-29)27-19-8-3-2-4-9-19/h5-7,10,15,19,27,30H,2-4,8-9,11-14,16H2,1H3 BUGFIJBRGRSZPF-UHFFFAOYSA-N 156427 US9682966, 222::US10118915, Compound 222::US20250346584, Compound 222 Kappa-type opioid receptor Homo sapiens 163 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156427&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263770 355041531 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572686 Cc1noc(n1)-c1cc(C)c(C)nc1N1CCC(NC2CCCC2)C(CO)C1 InChI=1S/C21H31N5O2/c1-13-10-18(21-23-15(3)25-28-21)20(22-14(13)2)26-9-8-19(16(11-26)12-27)24-17-6-4-5-7-17/h10,16-17,19,24,27H,4-9,11-12H2,1-3H3 YQQKIQWJJZOCLC-UHFFFAOYSA-N 156428 US9682966, 223::US10118915, Compound 223::US20250346584, Compound 223 Kappa-type opioid receptor Homo sapiens 13.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156428&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263767 355041532 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572687 CC1CCCCC1NC1CCN(CC1CO)c1nc(C)c(C)cc1-c1nc(C)no1 |w:7.7,1.0| InChI=1S/C23H35N5O2/c1-14-7-5-6-8-20(14)26-21-9-10-28(12-18(21)13-29)22-19(11-15(2)16(3)24-22)23-25-17(4)27-30-23/h11,14,18,20-21,26,29H,5-10,12-13H2,1-4H3 RHOCANMSAKRZNP-UHFFFAOYSA-N 156429 US9682966, 224::US10118915, Compound 224::US20250346584, Compound 224 Kappa-type opioid receptor Homo sapiens 17.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156429 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156429&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263788 355041533 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572688 COC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1-c1ncco1 InChI=1S/C24H30N4O2/c1-29-22-16-28(13-11-21(22)26-18-8-3-2-4-9-18)23-19(24-25-12-14-30-24)15-17-7-5-6-10-20(17)27-23/h5-7,10,12,14-15,18,21-22,26H,2-4,8-9,11,13,16H2,1H3 DAEIPUMZIUMHHB-UHFFFAOYSA-N 156431 US9682966, 225::US10118915, Compound 225::US20250346584, Compound 225 Kappa-type opioid receptor Homo sapiens 70.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156431 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156431&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263771 355041534 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572689 OCC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1-c1ncco1 InChI=1S/C24H30N4O2/c29-16-18-15-28(12-10-22(18)26-19-7-2-1-3-8-19)23-20(24-25-11-13-30-24)14-17-6-4-5-9-21(17)27-23/h4-6,9,11,13-14,18-19,22,26,29H,1-3,7-8,10,12,15-16H2 AZIRADPKPZPHOA-UHFFFAOYSA-N 156432 US9682966, 226::US10118915, Compound 226::US20250346584, Compound 226 Kappa-type opioid receptor Homo sapiens 107 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156432&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263801 355041535 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572690 Cc1noc(n1)-c1cc2ccc(C)cc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C24H31N5O2/c1-15-8-9-17-13-19(24-25-16(2)28-31-24)23(27-21(17)12-15)29-11-10-20(22(30)14-29)26-18-6-4-3-5-7-18/h8-9,12-13,18,20,22,26,30H,3-7,10-11,14H2,1-2H3 IADRKEOEFZWGJA-UHFFFAOYSA-N 156433 US9682966, 227::US10118915, Compound 227::US20250346584, Compound 227 Kappa-type opioid receptor Homo sapiens 7.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156433 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156433&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263781 355041536 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572691 COC1CN(CCC1NC1CCCCC1)c1nc2cc(C)ccc2cc1-c1nc(C)no1 InChI=1S/C25H33N5O2/c1-16-9-10-18-14-20(25-26-17(2)29-32-25)24(28-22(18)13-16)30-12-11-21(23(15-30)31-3)27-19-7-5-4-6-8-19/h9-10,13-14,19,21,23,27H,4-8,11-12,15H2,1-3H3 NOSNEKDFWKAGPQ-UHFFFAOYSA-N 156434 US9682966, 228::US10118915, Compound 228::US20250346584, Compound 228 Kappa-type opioid receptor Homo sapiens 21.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156434&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263803 355041537 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572692 Cc1noc(n1)-c1cc2ccc(C)cc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C25H33N5O2/c1-16-8-9-18-13-21(25-26-17(2)29-32-25)24(28-23(18)12-16)30-11-10-22(19(14-30)15-31)27-20-6-4-3-5-7-20/h8-9,12-13,19-20,22,27,31H,3-7,10-11,14-15H2,1-2H3 LWNRBYWDPUQWTE-UHFFFAOYSA-N 156435 US9682966, 229::US10118915, Compound 229::US20250346584, Compound 229 Kappa-type opioid receptor Homo sapiens 5.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156435 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156435&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263772 355041538 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572693 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(CC1)NC1CCCCC1O InChI=1S/C23H29N5O2/c1-15-24-23(30-27-15)18-14-16-6-2-3-7-19(16)26-22(18)28-12-10-17(11-13-28)25-20-8-4-5-9-21(20)29/h2-3,6-7,14,17,20-21,25,29H,4-5,8-13H2,1H3 ZFANQAFRQAGLHJ-UHFFFAOYSA-N 156436 US9682966, 230::US10118915, Compound 230::US20250346584, Compound 230 Kappa-type opioid receptor Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156436&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263768 355041539 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572695 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C22H27N5O2/c1-15-23-22(29-26-15)19-14-16-4-2-3-5-20(16)25-21(19)27-10-6-17(7-11-27)24-18-8-12-28-13-9-18/h2-5,14,17-18,24H,6-13H2,1H3 BVXREYZTHJDAQA-UHFFFAOYSA-N 156438 US9682966, 232::US10118915, Compound 232::US20250346584, Compound 232 Kappa-type opioid receptor Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156438&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263802 355041541 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572696 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C23H29N5O2/c1-15-3-4-21-17(13-15)14-20(23-24-16(2)27-30-23)22(26-21)28-9-5-18(6-10-28)25-19-7-11-29-12-8-19/h3-4,13-14,18-19,25H,5-12H2,1-2H3 JHRCZIKHMOJCKF-UHFFFAOYSA-N 156439 US9682966, 233::US10118915, Compound 233::US20250346584, Compound 233 Kappa-type opioid receptor Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156439&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263805 355041542 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572697 Cc1noc(n1)-c1cc2ccccc2nc1N1CC(C1)NC1CCCCC1 InChI=1S/C21H25N5O/c1-14-22-21(27-25-14)18-11-15-7-5-6-10-19(15)24-20(18)26-12-17(13-26)23-16-8-3-2-4-9-16/h5-7,10-11,16-17,23H,2-4,8-9,12-13H2,1H3 VAGCOTXPKDJQOH-UHFFFAOYSA-N 156440 US9682966, 234::US10118915, Compound 234::US20250346584, Compound 234 Kappa-type opioid receptor Homo sapiens 596 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156440 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156440&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263804 355041543 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572698 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(CC1)NC1CCCOC1 InChI=1S/C22H27N5O2/c1-15-23-22(29-26-15)19-13-16-5-2-3-7-20(16)25-21(19)27-10-8-17(9-11-27)24-18-6-4-12-28-14-18/h2-3,5,7,13,17-18,24H,4,6,8-12,14H2,1H3 XJBNHLISSUAETR-UHFFFAOYSA-N 156441 US9682966, 235::US10118915, Compound 235::US20250346584, Compound 235 Kappa-type opioid receptor Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156441 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156441&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263806 355041544 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572699 Cc1noc(n1)-c1cc2ccccc2nc1N1CCC(CC1)NC1CCOC1 InChI=1S/C21H25N5O2/c1-14-22-21(28-25-14)18-12-15-4-2-3-5-19(15)24-20(18)26-9-6-16(7-10-26)23-17-8-11-27-13-17/h2-5,12,16-17,23H,6-11,13H2,1H3 PYSPOZGIWHRLPE-UHFFFAOYSA-N 156442 US9682966, 236::US10118915, Compound 236::US20250346584, Compound 236 Kappa-type opioid receptor Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156442 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156442&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263790 355041545 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572700 CCC(CC)NC1CCN(CC1)c1nc2ccccc2cc1-c1nc(C)no1 InChI=1S/C22H29N5O/c1-4-17(5-2)24-18-10-12-27(13-11-18)21-19(22-23-15(3)26-28-22)14-16-8-6-7-9-20(16)25-21/h6-9,14,17-18,24H,4-5,10-13H2,1-3H3 YOGHCIKNKAZOMB-UHFFFAOYSA-N 156443 US9682966, 237::US10118915, Compound 237::US20250346584, Compound 237 Kappa-type opioid receptor Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156443 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156443&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263777 355041546 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572701 Cc1noc(n1)-c1cc2cc(Cl)ccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C23H28ClN5O2/c1-14-25-23(31-28-14)18-12-15-11-16(24)7-8-19(15)27-22(18)29-10-9-20(21(30)13-29)26-17-5-3-2-4-6-17/h7-8,11-12,17,20-21,26,30H,2-6,9-10,13H2,1H3 RHKYRMPHXQBYDQ-UHFFFAOYSA-N 156444 US9682966, 238::US10118915, Compound 238::US20250346584, Compound 238 Kappa-type opioid receptor Homo sapiens 38.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156444 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156444&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263792 355041547 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572702 Cc1noc(n1)-c1cc2cc(Cl)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C24H30ClN5O2/c1-15-26-24(32-29-15)20-12-16-11-18(25)7-8-21(16)28-23(20)30-10-9-22(17(13-30)14-31)27-19-5-3-2-4-6-19/h7-8,11-12,17,19,22,27,31H,2-6,9-10,13-14H2,1H3 FKEGPEKRFDNEOI-UHFFFAOYSA-N 156445 US9682966, 239::US10118915, Compound 239::US20250346584, Compound 239 Kappa-type opioid receptor Homo sapiens 16.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156445 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156445&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263773 355041548 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572703 COC1CN(CCC1NC1CCCCC1)c1nc2ccc(Cl)cc2cc1-c1nc(C)no1 InChI=1S/C24H30ClN5O2/c1-15-26-24(32-29-15)19-13-16-12-17(25)8-9-20(16)28-23(19)30-11-10-21(22(14-30)31-2)27-18-6-4-3-5-7-18/h8-9,12-13,18,21-22,27H,3-7,10-11,14H2,1-2H3 CITUVOSXAXKRQK-UHFFFAOYSA-N 156446 US9682966, 240::US10118915, Compound 240::US20250346584, Compound 240 Kappa-type opioid receptor Homo sapiens 14.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156446 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156446&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263785 355041549 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572704 Cc1noc(n1)-c1cc2cc(F)ccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C23H28FN5O2/c1-14-25-23(31-28-14)18-12-15-11-16(24)7-8-19(15)27-22(18)29-10-9-20(21(30)13-29)26-17-5-3-2-4-6-17/h7-8,11-12,17,20-21,26,30H,2-6,9-10,13H2,1H3 VDEATFNADILFIC-UHFFFAOYSA-N 156447 US9682966, 241::US10118915, Compound 241::US20250346584, Compound 241 Kappa-type opioid receptor Homo sapiens 59.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156447 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156447&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263808 355041550 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572705 COC1CN(CCC1NC1CCCCC1)c1nc2ccc(F)cc2cc1-c1nc(C)no1 InChI=1S/C24H30FN5O2/c1-15-26-24(32-29-15)19-13-16-12-17(25)8-9-20(16)28-23(19)30-11-10-21(22(14-30)31-2)27-18-6-4-3-5-7-18/h8-9,12-13,18,21-22,27H,3-7,10-11,14H2,1-2H3 SIVMRYHCLBRURQ-UHFFFAOYSA-N 156448 US9682966, 242::US10118915, Compound 242::US20250346584, Compound 242 Kappa-type opioid receptor Homo sapiens 26.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156448 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156448&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263774 355041551 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572706 Cc1noc(n1)-c1cc2cc(F)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C24H30FN5O2/c1-15-26-24(32-29-15)20-12-16-11-18(25)7-8-21(16)28-23(20)30-10-9-22(17(13-30)14-31)27-19-5-3-2-4-6-19/h7-8,11-12,17,19,22,27,31H,2-6,9-10,13-14H2,1H3 LQIJUAPIMYWXID-UHFFFAOYSA-N 156449 US9682966, 243::US10118915, Compound 243::US20250346584, Compound 243 Kappa-type opioid receptor Homo sapiens 22.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156449 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156449&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263787 355041552 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572707 Cc1cnc(N2CC[C@@H](NC3CCCCC3)[C@H](O)C2)c(c1)-c1ncccn1 |r| InChI=1S/C21H29N5O/c1-15-12-17(20-22-9-5-10-23-20)21(24-13-15)26-11-8-18(19(27)14-26)25-16-6-3-2-4-7-16/h5,9-10,12-13,16,18-19,25,27H,2-4,6-8,11,14H2,1H3 MVDRNYUZERZMRY-UHFFFAOYSA-N 156450 US9682966, 244::US10118915, Compound 244::US20250346584, Compound 244 Kappa-type opioid receptor Homo sapiens 566 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156450 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156450&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263789 355041553 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572708 Cc1cnc(N2CCC(NC3CCCCC3)C(CO)C2)c(c1)-c1ncccn1 InChI=1S/C22H31N5O/c1-16-12-19(21-23-9-5-10-24-21)22(25-13-16)27-11-8-20(17(14-27)15-28)26-18-6-3-2-4-7-18/h5,9-10,12-13,17-18,20,26,28H,2-4,6-8,11,14-15H2,1H3 POGSZRSTPCEFJX-UHFFFAOYSA-N 156451 US9682966, 245::US10118915, Compound 245::US20250346584, Compound 245 Kappa-type opioid receptor Homo sapiens 79.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156451 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156451&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263794 355041554 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572709 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCC(O)CC1 |(3.24,2.46,;1.7,2.46,;.8,3.7,;-.67,3.23,;-.67,1.69,;.8,1.21,;-2,.92,;-3.33,1.69,;-4.67,.92,;-6,1.69,;-7.34,.92,;-8.67,1.69,;-7.34,-.62,;-6,-1.39,;-4.67,-.62,;-3.33,-1.39,;-2,-.62,;-.67,-1.39,;-.67,-2.93,;.67,-3.7,;2,-2.93,;2,-1.39,;.67,-.62,;3.33,-3.7,;4.67,-2.93,;6,-3.7,;7.34,-2.93,;7.34,-1.39,;8.67,-.62,;6,-.62,;4.67,-1.39,)| InChI=1S/C24H31N5O2/c1-15-3-8-22-17(13-15)14-21(24-25-16(2)28-31-24)23(27-22)29-11-9-19(10-12-29)26-18-4-6-20(30)7-5-18/h3,8,13-14,18-20,26,30H,4-7,9-12H2,1-2H3 CKCHTUDEUHHSPJ-UHFFFAOYSA-N 156452 US9682966, 246::US10118915, Compound 246::US20250346584, Compound 246 Kappa-type opioid receptor Homo sapiens 51.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156452 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156452&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263811 355041555 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572710 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCOC1 InChI=1S/C23H29N5O2/c1-15-5-6-21-17(12-15)13-20(23-24-16(2)27-30-23)22(26-21)28-9-7-18(8-10-28)25-19-4-3-11-29-14-19/h5-6,12-13,18-19,25H,3-4,7-11,14H2,1-2H3 PRHKYYOUHVQLBX-UHFFFAOYSA-N 156453 US9682966, 247::US10118915, Compound 247::US20250346584, Compound 247 Kappa-type opioid receptor Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156453 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156453&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263793 355041556 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572712 COC1CN(CCC1NC1CCCCC1F)c1nc2ccc(C)cc2cc1-c1nc(C)no1 |w:8.9,14.16| InChI=1S/C25H32FN5O2/c1-15-8-9-20-17(12-15)13-18(25-27-16(2)30-33-25)24(29-20)31-11-10-22(23(14-31)32-3)28-21-7-5-4-6-19(21)26/h8-9,12-13,19,21-23,28H,4-7,10-11,14H2,1-3H3 ITXZQVSUUPLRGU-UHFFFAOYSA-N 156455 US9682966, 249::US10118915, Compound 249::US20250346584, Compound 249 Kappa-type opioid receptor Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156455 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156455&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263795 355041558 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572713 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCCC1F |w:23.27,29.34| InChI=1S/C24H30FN5O/c1-15-7-8-21-17(13-15)14-19(24-26-16(2)29-31-24)23(28-21)30-11-9-18(10-12-30)27-22-6-4-3-5-20(22)25/h7-8,13-14,18,20,22,27H,3-6,9-12H2,1-2H3 UATJOQGLJXQITJ-UHFFFAOYSA-N 156456 US9682966, 250::US10118915, Compound 250::US20250346584, Compound 250 Kappa-type opioid receptor Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156456&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263813 355041559 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572714 Cc1noc(n1)-c1cc2c(F)cccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](O)C1 |r| InChI=1S/C23H28FN5O2/c1-14-25-23(31-28-14)17-12-16-18(24)8-5-9-19(16)27-22(17)29-11-10-20(21(30)13-29)26-15-6-3-2-4-7-15/h5,8-9,12,15,20-21,26,30H,2-4,6-7,10-11,13H2,1H3 CDRPXGSTBMEYCV-UHFFFAOYSA-N 156457 US9682966, 251::US10118915, Compound 251::US20250346584, Compound 251 Kappa-type opioid receptor Homo sapiens 11.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156457 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156457&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263815 355041560 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572715 COC1CN(CCC1NC1CCCCC1)c1nc2cccc(F)c2cc1-c1nc(C)no1 InChI=1S/C24H30FN5O2/c1-15-26-24(32-29-15)18-13-17-19(25)9-6-10-20(17)28-23(18)30-12-11-21(22(14-30)31-2)27-16-7-4-3-5-8-16/h6,9-10,13,16,21-22,27H,3-5,7-8,11-12,14H2,1-2H3 AQAGMWIEZLEMBH-UHFFFAOYSA-N 156458 US9682966, 252::US10118915, Compound 252::US20250346584, Compound 252 Kappa-type opioid receptor Homo sapiens 12.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156458 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156458&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263817 355041561 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572716 Cc1noc(n1)-c1cc2c(F)cccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C24H30FN5O2/c1-15-26-24(32-29-15)19-12-18-20(25)8-5-9-22(18)28-23(19)30-11-10-21(16(13-30)14-31)27-17-6-3-2-4-7-17/h5,8-9,12,16-17,21,27,31H,2-4,6-7,10-11,13-14H2,1H3 RKWRHRJYLIEXIJ-UHFFFAOYSA-N 156459 US9682966, 253::US10118915, Compound 253::US20250346584, Compound 253 Kappa-type opioid receptor Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156459&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263796 355041562 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572717 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCOC1 InChI=1S/C22H27N5O2/c1-14-3-4-20-16(11-14)12-19(22-23-15(2)26-29-22)21(25-20)27-8-5-17(6-9-27)24-18-7-10-28-13-18/h3-4,11-12,17-18,24H,5-10,13H2,1-2H3 BYAPJICYDVKSMT-UHFFFAOYSA-N 156460 US9682966, 254::US10118915, Compound 254::US20250346584, Compound 254 Kappa-type opioid receptor Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156460 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156460&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263798 355041563 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572718 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCC(O)C1 |w:23.27,28.32| InChI=1S/C24H31N5O2/c1-15-6-7-22-17(12-15)13-21(24-25-16(2)28-31-24)23(27-22)29-10-8-18(9-11-29)26-19-4-3-5-20(30)14-19/h6-7,12-13,18-20,26,30H,3-5,8-11,14H2,1-2H3 OCTBNQMEOOPCEU-UHFFFAOYSA-N 156461 US9682966, 255::US10118915, Compound 255::US20250346584, Compound 255 Kappa-type opioid receptor Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156461 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156461&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263820 355041564 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572719 Cc1noc(n1)-c1cc2ccc(C)cc2nc1N1CCC(CC1)NC1CCCCC1O InChI=1S/C24H31N5O2/c1-15-7-8-17-14-19(24-25-16(2)28-31-24)23(27-21(17)13-15)29-11-9-18(10-12-29)26-20-5-3-4-6-22(20)30/h7-8,13-14,18,20,22,26,30H,3-6,9-12H2,1-2H3 PWAKYYZGGHFZRT-UHFFFAOYSA-N 156462 US9682966, 256::US10118915, Compound 256::US20250346584, Compound 256 Kappa-type opioid receptor Homo sapiens 631 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156462 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156462&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263816 355041565 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572720 Cc1noc(n1)-c1cc2ccc(C)cc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C23H29N5O2/c1-15-3-4-17-14-20(23-24-16(2)27-30-23)22(26-21(17)13-15)28-9-5-18(6-10-28)25-19-7-11-29-12-8-19/h3-4,13-14,18-19,25H,5-12H2,1-2H3 RBNFMUSHNWUGHC-UHFFFAOYSA-N 156463 US9682966, 257::US10118915, Compound 257::US20250346584, Compound 257 Kappa-type opioid receptor Homo sapiens 930 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156463&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263791 355041566 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572721 COC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1C1=NCC(C)O1 |t:29| InChI=1S/C25H34N4O2/c1-17-15-26-25(31-17)20-14-18-8-6-7-11-21(18)28-24(20)29-13-12-22(23(16-29)30-2)27-19-9-4-3-5-10-19/h6-8,11,14,17,19,22-23,27H,3-5,9-10,12-13,15-16H2,1-2H3 XBFFERALCRGQSK-UHFFFAOYSA-N 156464 US9682966, 258::US20250346584, Compound 258 Kappa-type opioid receptor Homo sapiens 7160 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156464 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156464&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263807 355041567 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572722 COC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1C1=NC(C)CO1 |t:29| InChI=1S/C25H34N4O2/c1-17-16-31-25(26-17)20-14-18-8-6-7-11-21(18)28-24(20)29-13-12-22(23(15-29)30-2)27-19-9-4-3-5-10-19/h6-8,11,14,17,19,22-23,27H,3-5,9-10,12-13,15-16H2,1-2H3 NHMTXQUVMUXXIL-UHFFFAOYSA-N 156465 US9682966, 259::US10118915, Compound 259::US20250346584, Compound 259 Kappa-type opioid receptor Homo sapiens 372 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156465 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156465&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263828 355041568 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572723 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCCCCC1 InChI=1S/C26H35N5O/c1-18-10-11-24-20(16-18)17-23(26-27-19(2)30-32-26)25(29-24)31-14-12-22(13-15-31)28-21-8-6-4-3-5-7-9-21/h10-11,16-17,21-22,28H,3-9,12-15H2,1-2H3 APUCPAZASGKGDA-UHFFFAOYSA-N 156466 US9682966, 260::US10118915, Compound 260::US20250346584, Compound 260 Kappa-type opioid receptor Homo sapiens 261 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156466 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156466&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263818 355041569 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572724 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NCC1CCCCC1 InChI=1S/C25H33N5O/c1-17-8-9-23-20(14-17)15-22(25-27-18(2)29-31-25)24(28-23)30-12-10-21(11-13-30)26-16-19-6-4-3-5-7-19/h8-9,14-15,19,21,26H,3-7,10-13,16H2,1-2H3 CLOSPXSPNCGZCF-UHFFFAOYSA-N 156467 US9682966, 261::US10118915, Compound 261::US20250346584, Compound 261 Kappa-type opioid receptor Homo sapiens 1470 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156467 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156467&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263809 355041570 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572725 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NCC1CCCO1 InChI=1S/C23H29N5O2/c1-15-5-6-21-17(12-15)13-20(23-25-16(2)27-30-23)22(26-21)28-9-7-18(8-10-28)24-14-19-4-3-11-29-19/h5-6,12-13,18-19,24H,3-4,7-11,14H2,1-2H3 RUSRYWUIAYIWJL-UHFFFAOYSA-N 156468 US9682966, 262::US10118915, Compound 262::US20250346584, Compound 262 Kappa-type opioid receptor Homo sapiens 60.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156468 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156468&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263827 355041571 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572726 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)Nc1ncccn1 InChI=1S/C22H23N7O/c1-14-4-5-19-16(12-14)13-18(21-25-15(2)28-30-21)20(27-19)29-10-6-17(7-11-29)26-22-23-8-3-9-24-22/h3-5,8-9,12-13,17H,6-7,10-11H2,1-2H3,(H,23,24,26) LZZYJIUFAFXRNG-UHFFFAOYSA-N 156469 US9682966, C83::US10118915, Compound C83::US20250346584, Compound C83 Kappa-type opioid receptor Homo sapiens 47000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156469 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156469&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263822 355041572 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572727 COC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1-c1ncccn1 InChI=1S/C25H31N5O/c1-31-23-17-30(15-12-22(23)28-19-9-3-2-4-10-19)25-20(24-26-13-7-14-27-24)16-18-8-5-6-11-21(18)29-25/h5-8,11,13-14,16,19,22-23,28H,2-4,9-10,12,15,17H2,1H3 SJLVXRIZQQICEU-UHFFFAOYSA-N 156470 US9682966, 263::US10118915, Compound 263::US20250346584, Compound 263 Kappa-type opioid receptor Homo sapiens 1770 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156470 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156470&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263852 355041573 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572728 OCC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1-c1ncccn1 InChI=1S/C25H31N5O/c31-17-19-16-30(14-11-23(19)28-20-8-2-1-3-9-20)25-21(24-26-12-6-13-27-24)15-18-7-4-5-10-22(18)29-25/h4-7,10,12-13,15,19-20,23,28,31H,1-3,8-9,11,14,16-17H2 LAALUSHLQXMTEI-UHFFFAOYSA-N 156471 US9682966, 264::US10118915, Compound 264::US20250346584, Compound 264 Kappa-type opioid receptor Homo sapiens 56.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156471 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156471&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263824 355041574 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572729 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CC2CCC1C2 InChI=1S/C25H31N5O/c1-15-3-6-22-19(11-15)14-21(25-26-16(2)29-31-25)24(28-22)30-9-7-20(8-10-30)27-23-13-17-4-5-18(23)12-17/h3,6,11,14,17-18,20,23,27H,4-5,7-10,12-13H2,1-2H3 YXUSUDLTLYUCCI-UHFFFAOYSA-N 156472 US9682966, 265::US10118915, Compound 265::US20250346584, Compound 265 Kappa-type opioid receptor Homo sapiens 49.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156472 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156472&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263821 355041575 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572730 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)N1CCCCC1 InChI=1S/C23H29N5O/c1-16-6-7-21-18(14-16)15-20(23-24-17(2)26-29-23)22(25-21)28-12-8-19(9-13-28)27-10-4-3-5-11-27/h6-7,14-15,19H,3-5,8-13H2,1-2H3 ADLYKPKJJUYYPL-UHFFFAOYSA-N 156473 US9682966, 266::US10118915, Compound 266::US20250346584, Compound 266 Kappa-type opioid receptor Homo sapiens 1740 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156473 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156473&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263831 355041576 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572731 CN(C1CCOCC1)C1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C24H31N5O2/c1-16-4-5-22-18(14-16)15-21(24-25-17(2)27-31-24)23(26-22)29-10-6-19(7-11-29)28(3)20-8-12-30-13-9-20/h4-5,14-15,19-20H,6-13H2,1-3H3 PWNFCTOCASJCIK-UHFFFAOYSA-N 156474 US9682966, 267::US10118915, Compound 267::US20250346584, Compound 267 Kappa-type opioid receptor Homo sapiens 180 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156474 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156474&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263836 355041577 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572732 CCc1ccc2nc(N3CCC(NC4CCCCC4)C(C3)OC)c(cc2c1)-c1nc(C)no1 InChI=1S/C26H35N5O2/c1-4-18-10-11-22-19(14-18)15-21(26-27-17(2)30-33-26)25(29-22)31-13-12-23(24(16-31)32-3)28-20-8-6-5-7-9-20/h10-11,14-15,20,23-24,28H,4-9,12-13,16H2,1-3H3 LYESPAOKPAXPCR-UHFFFAOYSA-N 156475 US9682966, 268::US10118915, Compound 268::US20250346584, Compound 268 Kappa-type opioid receptor Homo sapiens 37.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156475 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156475&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263837 355041578 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572733 CCc1ccc2nc(N3CCC(NC4CCCCC4)C(CO)C3)c(cc2c1)-c1nc(C)no1 InChI=1S/C26H35N5O2/c1-3-18-9-10-23-19(13-18)14-22(26-27-17(2)30-33-26)25(29-23)31-12-11-24(20(15-31)16-32)28-21-7-5-4-6-8-21/h9-10,13-14,20-21,24,28,32H,3-8,11-12,15-16H2,1-2H3 YQDSWSBEUMQOFO-UHFFFAOYSA-N 156476 US9682966, 269::US10118915, Compound 269::US20250346584, Compound 269 Kappa-type opioid receptor Homo sapiens 30.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156476 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156476&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263844 355041579 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572734 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1COC1 InChI=1S/C21H25N5O2/c1-13-3-4-19-15(9-13)10-18(21-22-14(2)25-28-21)20(24-19)26-7-5-16(6-8-26)23-17-11-27-12-17/h3-4,9-10,16-17,23H,5-8,11-12H2,1-2H3 PEDYXWNZFNHHAY-UHFFFAOYSA-N 156477 US9682966, 270::US10118915, Compound 270::US20250346584, Compound 270 Kappa-type opioid receptor Homo sapiens 4470 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156477 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156477&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263839 355041580 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572735 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1(C)CCOCC1 InChI=1S/C24H31N5O2/c1-16-4-5-21-18(14-16)15-20(23-25-17(2)28-31-23)22(26-21)29-10-6-19(7-11-29)27-24(3)8-12-30-13-9-24/h4-5,14-15,19,27H,6-13H2,1-3H3 GXKCQJCAJBCCLI-UHFFFAOYSA-N 156480 US9682966, 271::US10118915, Compound 271::US20250346584, Compound 271 Kappa-type opioid receptor Homo sapiens 419 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156480 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156480&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263835 355041581 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572736 C\C(N)=C\C(=C(/N)N1CCC(CC1)NC1CCOCC1)\c1nc(C)no1 InChI=1S/C18H30N6O2/c1-12(19)11-16(18-21-13(2)23-26-18)17(20)24-7-3-14(4-8-24)22-15-5-9-25-10-6-15/h11,14-15,22H,3-10,19-20H2,1-2H3 GXMMMCYGQASZPL-UHFFFAOYSA-N 156481 US9682966, 272::US20250346584, Compound 272 Kappa-type opioid receptor Homo sapiens 8700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156481 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156481&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263838 355041582 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572737 COC1CN(CCC1NC1CCCCC1)c1nc2ccc(C)cc2cc1-c1nnc(C)o1 InChI=1S/C25H33N5O2/c1-16-9-10-21-18(13-16)14-20(25-29-28-17(2)32-25)24(27-21)30-12-11-22(23(15-30)31-3)26-19-7-5-4-6-8-19/h9-10,13-14,19,22-23,26H,4-8,11-12,15H2,1-3H3 VDNBLJBHYPJXRD-UHFFFAOYSA-N 298011 US10118915, Compound 273::US20250346584, Compound 273 Kappa-type opioid receptor Homo sapiens 387 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=298011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=298011&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264137 381620843 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572738 CC1CC(CC(C)O1)NC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C25H33N5O2/c1-15-5-6-23-19(11-15)14-22(25-26-18(4)29-32-25)24(28-23)30-9-7-20(8-10-30)27-21-12-16(2)31-17(3)13-21/h5-6,11,14,16-17,20-21,27H,7-10,12-13H2,1-4H3 QWCODRPFPSGHNX-UHFFFAOYSA-N 156484 US9682966, 274::US10118915, Compound 274::US20250346584, Compound 274 Kappa-type opioid receptor Homo sapiens 50.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156484 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156484&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263840 355041584 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572739 Cc1noc(n1)-c1cc2cccc(C)c2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C23H29N5O2/c1-15-4-3-5-17-14-20(23-24-16(2)27-30-23)22(26-21(15)17)28-10-6-18(7-11-28)25-19-8-12-29-13-9-19/h3-5,14,18-19,25H,6-13H2,1-2H3 PJLZYBFHWYGAGX-UHFFFAOYSA-N 156485 US9682966, 275::US10118915, Compound 275::US20250346584, Compound 275 Kappa-type opioid receptor Homo sapiens 98.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156485 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156485&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263845 355041585 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572740 COC1CN(CCC1NC1CCCCC1)c1nc2c(C)cccc2cc1-c1nc(C)no1 InChI=1S/C25H33N5O2/c1-16-8-7-9-18-14-20(25-26-17(2)29-32-25)24(28-23(16)18)30-13-12-21(22(15-30)31-3)27-19-10-5-4-6-11-19/h7-9,14,19,21-22,27H,4-6,10-13,15H2,1-3H3 RQRNWELACYXOCO-UHFFFAOYSA-N 156486 US9682966, 276::US10118915, Compound 276::US20250346584, Compound 276 Kappa-type opioid receptor Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156486 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156486&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263843 355041586 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572741 Cc1noc(n1)-c1cc2cccc(C)c2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C25H33N5O2/c1-16-7-6-8-18-13-21(25-26-17(2)29-32-25)24(28-23(16)18)30-12-11-22(19(14-30)15-31)27-20-9-4-3-5-10-20/h6-8,13,19-20,22,27,31H,3-5,9-12,14-15H2,1-2H3 PNZGGWVSUZKRJF-UHFFFAOYSA-N 156488 US9682966, 277::US10118915, Compound 277::US20250346584, Compound 277 Kappa-type opioid receptor Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156488 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156488&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263851 355041587 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572742 CNC(=O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(C1)OC InChI=1S/C24H34N4O2/c1-16-9-10-20-17(13-16)14-19(24(29)25-2)23(27-20)28-12-11-21(22(15-28)30-3)26-18-7-5-4-6-8-18/h9-10,13-14,18,21-22,26H,4-8,11-12,15H2,1-3H3,(H,25,29) YDPRQVRPIWZFAX-UHFFFAOYSA-N 156489 US9682966, 278::US10118915, Compound 278::US20250346584, Compound 278 Kappa-type opioid receptor Homo sapiens 4725 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156489 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156489&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263853 355041588 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572743 COC1CN(CCC1NC1CCCCC1)c1nc2ccc(C)cc2cc1C(=O)N(C)C InChI=1S/C25H36N4O2/c1-17-10-11-21-18(14-17)15-20(25(30)28(2)3)24(27-21)29-13-12-22(23(16-29)31-4)26-19-8-6-5-7-9-19/h10-11,14-15,19,22-23,26H,5-9,12-13,16H2,1-4H3 SWHDSKKAWPZODL-UHFFFAOYSA-N 156490 US9682966, 279::US10118915, Compound 279::US20250346584, Compound 279 Kappa-type opioid receptor Homo sapiens 96.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156490 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156490&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263848 355041589 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572744 CN(C)C(=O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C25H36N4O2/c1-17-9-10-22-18(13-17)14-21(25(31)28(2)3)24(27-22)29-12-11-23(19(15-29)16-30)26-20-7-5-4-6-8-20/h9-10,13-14,19-20,23,26,30H,4-8,11-12,15-16H2,1-3H3 YXUROQKHWSXFQE-UHFFFAOYSA-N 156491 US9682966, 280::US10118915, Compound 280::US20250346584, Compound 280 Kappa-type opioid receptor Homo sapiens 99.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156491 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156491&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263855 355041590 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572745 CCOC(=O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(C1)OC InChI=1S/C25H35N3O3/c1-4-31-25(29)20-15-18-14-17(2)10-11-21(18)27-24(20)28-13-12-22(23(16-28)30-3)26-19-8-6-5-7-9-19/h10-11,14-15,19,22-23,26H,4-9,12-13,16H2,1-3H3 XOMGZAJHWYITRT-UHFFFAOYSA-N 156493 US9682966, 281::US10118915, Compound 281::US20250346584, Compound 281 Kappa-type opioid receptor Homo sapiens 30.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156493 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156493&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263856 355041591 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572746 COC1CN(CCC1NC1CCCCC1)c1nc2ccc(C)cc2cc1C(=O)OC(C)C InChI=1S/C26H37N3O3/c1-17(2)32-26(30)21-15-19-14-18(3)10-11-22(19)28-25(21)29-13-12-23(24(16-29)31-4)27-20-8-6-5-7-9-20/h10-11,14-15,17,20,23-24,27H,5-9,12-13,16H2,1-4H3 CLRXGWFAQYJWRY-UHFFFAOYSA-N 156494 US9682966, 282::US10118915, Compound 282::US20250346584, Compound 282 Kappa-type opioid receptor Homo sapiens 38.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156494&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263854 355041592 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572747 CCc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(C1)OC InChI=1S/C26H35N5O2/c1-4-24-29-26(33-30-24)20-15-18-14-17(2)10-11-21(18)28-25(20)31-13-12-22(23(16-31)32-3)27-19-8-6-5-7-9-19/h10-11,14-15,19,22-23,27H,4-9,12-13,16H2,1-3H3 CCXLPYDZSRSDCB-UHFFFAOYSA-N 156496 US9682966, 283::US10118915, Compound 283::US20250346584, Compound 283 Kappa-type opioid receptor Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156496&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263859 355041593 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572748 CCc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C26H35N5O2/c1-3-24-29-26(33-30-24)21-14-18-13-17(2)9-10-22(18)28-25(21)31-12-11-23(19(15-31)16-32)27-20-7-5-4-6-8-20/h9-10,13-14,19-20,23,27,32H,3-8,11-12,15-16H2,1-2H3 UNMOLWKGAKQIKJ-UHFFFAOYSA-N 156497 US9682966, 284::US10118915, Compound 284::US20250346584, Compound 284 Kappa-type opioid receptor Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156497 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156497&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263858 355041594 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572749 CCc1ccc2nc(N3CCC(CC3)NC3CCOCC3)c(cc2c1)-c1nc(C)no1 InChI=1S/C24H31N5O2/c1-3-17-4-5-22-18(14-17)15-21(24-25-16(2)28-31-24)23(27-22)29-10-6-19(7-11-29)26-20-8-12-30-13-9-20/h4-5,14-15,19-20,26H,3,6-13H2,1-2H3 BUHJLSMTUCQODW-UHFFFAOYSA-N 156498 US9682966, 285::US10118915, Compound 285::US20250346584, Compound 285 Kappa-type opioid receptor Homo sapiens 7.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156498&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263857 355041595 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572750 C1CC(CCO1)NC1CCN(CC1)c1nc2ccccc2cc1-c1ncccn1 InChI=1S/C23H27N5O/c1-2-5-21-17(4-1)16-20(22-24-10-3-11-25-22)23(27-21)28-12-6-18(7-13-28)26-19-8-14-29-15-9-19/h1-5,10-11,16,18-19,26H,6-9,12-15H2 HKHOLGQTCACOGY-UHFFFAOYSA-N 156499 US9682966, 286::US10118915, Compound 286::US20250346584, Compound 286 Kappa-type opioid receptor Homo sapiens 298 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156499 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156499&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263860 355041596 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572751 CCOC(=O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C25H35N3O3/c1-3-31-25(30)21-14-18-13-17(2)9-10-22(18)27-24(21)28-12-11-23(19(15-28)16-29)26-20-7-5-4-6-8-20/h9-10,13-14,19-20,23,26,29H,3-8,11-12,15-16H2,1-2H3 LERBXDXPVAPRFF-UHFFFAOYSA-N 156500 US9682966, 288::US10118915, Compound 288::US20250346584, Compound 288 Kappa-type opioid receptor Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156500&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263861 355041597 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572752 CCOC(=O)c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C23H31N3O3/c1-3-29-23(27)20-15-17-14-16(2)4-5-21(17)25-22(20)26-10-6-18(7-11-26)24-19-8-12-28-13-9-19/h4-5,14-15,18-19,24H,3,6-13H2,1-2H3 WMTBTNRWXFZIRW-UHFFFAOYSA-N 156501 US9682966, 289::US10118915, Compound 289::US20250346584, Compound 289 Kappa-type opioid receptor Homo sapiens 184 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156501 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156501&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263862 355041598 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572753 CCc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C24H31N5O2/c1-3-22-27-24(31-28-22)20-15-17-14-16(2)4-5-21(17)26-23(20)29-10-6-18(7-11-29)25-19-8-12-30-13-9-19/h4-5,14-15,18-19,25H,3,6-13H2,1-2H3 IJGHDAAORRPMEY-UHFFFAOYSA-N 156502 US9682966, 290::US10118915, Compound 290::US20250346584, Compound 290 Kappa-type opioid receptor Homo sapiens 47.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156502 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156502&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263863 355041599 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572754 CC(C)OC(=O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C26H37N3O3/c1-17(2)32-26(31)22-14-19-13-18(3)9-10-23(19)28-25(22)29-12-11-24(20(15-29)16-30)27-21-7-5-4-6-8-21/h9-10,13-14,17,20-21,24,27,30H,4-8,11-12,15-16H2,1-3H3 UFSTVCMRDJRFDO-UHFFFAOYSA-N 156503 US9682966, 291::US10118915, Compound 291::US20250346584, Compound 291 Kappa-type opioid receptor Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156503&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263864 355041600 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572755 COC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1-c1nc(C)no1 InChI=1S/C24H31N5O2/c1-16-25-24(31-28-16)19-14-17-8-6-7-11-20(17)27-23(19)29-13-12-21(22(15-29)30-2)26-18-9-4-3-5-10-18/h6-8,11,14,18,21-22,26H,3-5,9-10,12-13,15H2,1-2H3 LYPIJTFCQSRMIO-UHFFFAOYSA-N 156131 US9682966, 292::US9682966, 176::US10118915, Compound 292::US20250346584, Compound 292 Kappa-type opioid receptor Homo sapiens 33.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156131&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296191 355041484 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572756 COC1CN(CCC1NC1CCCCC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C25H33N5O2/c1-16-9-10-21-18(13-16)14-20(25-26-17(2)29-32-25)24(28-21)30-12-11-22(23(15-30)31-3)27-19-7-5-4-6-8-19/h9-10,13-14,19,22-23,27H,4-8,11-12,15H2,1-3H3 PGXSSLBJKPYNJE-UHFFFAOYSA-N 156379 US9682966, 293::US9682966, 214::US10118915, Compound 293::US20250346584, Compound 293 Kappa-type opioid receptor Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156379&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263765 355041521 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572757 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 |r| InChI=1S/C25H33N5O2/c1-16-9-10-21-18(13-16)14-20(25-26-17(2)29-32-25)24(28-21)30-12-11-22(23(15-30)31-3)27-19-7-5-4-6-8-19/h9-10,13-14,19,22-23,27H,4-8,11-12,15H2,1-3H3 PGXSSLBJKPYNJE-UHFFFAOYSA-N 156507 US9682966, 294::US10118915, Compound 294::US20250346584, Compound 294 Kappa-type opioid receptor Homo sapiens 0.700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156507&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263865 355041601 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572758 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccccc2cc1-c1nc(C)no1 |r| InChI=1S/C24H31N5O2/c1-16-25-24(31-28-16)19-14-17-8-6-7-11-20(17)27-23(19)29-13-12-21(22(15-29)30-2)26-18-9-4-3-5-10-18/h6-8,11,14,18,21-22,26H,3-5,9-10,12-13,15H2,1-2H3 LYPIJTFCQSRMIO-UHFFFAOYSA-N 156508 US9682966, 295::US10118915, Compound 295::US20250346584, Compound 295 Kappa-type opioid receptor Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156508 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156508&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263866 355041602 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572759 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccc(F)cc2cc1-c1nc(C)no1 |r| InChI=1S/C24H30FN5O2/c1-15-26-24(32-29-15)19-13-16-12-17(25)8-9-20(16)28-23(19)30-11-10-21(22(14-30)31-2)27-18-6-4-3-5-7-18/h8-9,12-13,18,21-22,27H,3-7,10-11,14H2,1-2H3 SIVMRYHCLBRURQ-UHFFFAOYSA-N 156509 US9682966, 296::US10118915, Compound 296::US20250346584, Compound 296 Kappa-type opioid receptor Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156509&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263867 355041603 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572760 CCc1noc(n1)-c1cc2cc(C)ccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](C1)OC |r| InChI=1S/C26H35N5O2/c1-4-24-29-26(33-30-24)20-15-18-14-17(2)10-11-21(18)28-25(20)31-13-12-22(23(16-31)32-3)27-19-8-6-5-7-9-19/h10-11,14-15,19,22-23,27H,4-9,12-13,16H2,1-3H3 CCXLPYDZSRSDCB-UHFFFAOYSA-N 156510 US9682966, 297::US10118915, Compound 297::US20250346584, Compound 297 Kappa-type opioid receptor Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156510&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263868 355041604 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572761 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)C(\N)=C(\C=C(\C)N)/c1nc(C)no1 |r| InChI=1S/C20H34N6O2/c1-13(21)11-16(20-23-14(2)25-28-20)19(22)26-10-9-17(18(12-26)27-3)24-15-7-5-4-6-8-15/h11,15,17-18,24H,4-10,12,21-22H2,1-3H3 CVETVIQDECOYEO-UHFFFAOYSA-N 156511 US9682966, 298::US20250346584, Compound 298 Kappa-type opioid receptor Homo sapiens 3.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156511 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156511&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263869 355041605 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572762 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1ncc(C)cc1-c1nc(C)no1 |r| InChI=1S/C21H31N5O2/c1-14-11-17(21-23-15(2)25-28-21)20(22-12-14)26-10-9-18(19(13-26)27-3)24-16-7-5-4-6-8-16/h11-12,16,18-19,24H,4-10,13H2,1-3H3 KPFOVAJOPSVOTB-UHFFFAOYSA-N 156512 US9682966, 299::US10118915, Compound 299::US20250346584, Compound 299 Kappa-type opioid receptor Homo sapiens 25.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156512 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156512&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263870 355041606 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572763 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc(C)c(C)cc1-c1nc(C)no1 |r| InChI=1S/C22H33N5O2/c1-14-12-18(22-24-16(3)26-29-22)21(23-15(14)2)27-11-10-19(20(13-27)28-4)25-17-8-6-5-7-9-17/h12,17,19-20,25H,5-11,13H2,1-4H3 SVNGXQIDULLYNM-UHFFFAOYSA-N 156513 US9682966, 300::US10118915, Compound 300::US20250346584, Compound 300 Kappa-type opioid receptor Homo sapiens 16.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156513 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156513&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263871 355041607 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572764 Cc1nnc(o1)-c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C25H33N5O2/c1-16-8-9-22-18(12-16)13-21(25-29-28-17(2)32-25)24(27-22)30-11-10-23(19(14-30)15-31)26-20-6-4-3-5-7-20/h8-9,12-13,19-20,23,26,31H,3-7,10-11,14-15H2,1-2H3 YJRLNSQUCPKJIT-UHFFFAOYSA-N 156514 US9682966, 301::US10118915, Compound 301::US20250346584, Compound 301 Kappa-type opioid receptor Homo sapiens 38.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156514 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156514&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263872 355041608 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572765 CC(C)OC(=O)c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C24H33N3O3/c1-16(2)30-24(28)21-15-18-14-17(3)4-5-22(18)26-23(21)27-10-6-19(7-11-27)25-20-8-12-29-13-9-20/h4-5,14-16,19-20,25H,6-13H2,1-3H3 YJRMHKWJGSRSIA-UHFFFAOYSA-N 156515 US9682966, 302::US10118915, Compound 302::US20250346584, Compound 302 Kappa-type opioid receptor Homo sapiens 274 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156515 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156515&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263874 355041609 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572766 COC1CN(CCC1NC1CCCCC1)c1nc2ccc(C)cc2cc1-c1nc(no1)C1CC1 InChI=1S/C27H35N5O2/c1-17-8-11-22-19(14-17)15-21(27-30-25(31-34-27)18-9-10-18)26(29-22)32-13-12-23(24(16-32)33-2)28-20-6-4-3-5-7-20/h8,11,14-15,18,20,23-24,28H,3-7,9-10,12-13,16H2,1-2H3 RDZRZHRSUGKPFT-UHFFFAOYSA-N 156516 US9682966, 303::US10118915, Compound 303::US20250346584, Compound 303 Kappa-type opioid receptor Homo sapiens 0.500 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156516 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156516&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263873 355041610 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572767 Cc1ccc2nc(N3CCC(NC4CCCCC4)C(CO)C3)c(cc2c1)-c1nc(no1)C1CC1 InChI=1S/C27H35N5O2/c1-17-7-10-23-19(13-17)14-22(27-30-25(31-34-27)18-8-9-18)26(29-23)32-12-11-24(20(15-32)16-33)28-21-5-3-2-4-6-21/h7,10,13-14,18,20-21,24,28,33H,2-6,8-9,11-12,15-16H2,1H3 XHVDXTOMYQDQNT-UHFFFAOYSA-N 156518 US9682966, 304::US10118915, Compound 304::US20250346584, Compound 304 Kappa-type opioid receptor Homo sapiens 3.50 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156518 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156518&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263875 355041611 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572768 Cc1ccc2nc(N3CCC(CC3)NC3CCOCC3)c(cc2c1)-c1nc(no1)C1CC1 InChI=1S/C25H31N5O2/c1-16-2-5-22-18(14-16)15-21(25-28-23(29-32-25)17-3-4-17)24(27-22)30-10-6-19(7-11-30)26-20-8-12-31-13-9-20/h2,5,14-15,17,19-20,26H,3-4,6-13H2,1H3 PARBSCKRNFBXFZ-UHFFFAOYSA-N 156519 US9682966, 305::US10118915, Compound 305::US20250346584, Compound 305 Kappa-type opioid receptor Homo sapiens 17.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156519 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156519&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296773 355041612 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572769 COC1CN(CCC1NC1CCCCC1)c1nc2cc(C)c(C)cc2cc1-c1nc(C)no1 InChI=1S/C26H35N5O2/c1-16-12-19-14-21(26-27-18(3)30-33-26)25(29-23(19)13-17(16)2)31-11-10-22(24(15-31)32-4)28-20-8-6-5-7-9-20/h12-14,20,22,24,28H,5-11,15H2,1-4H3 OFDNGNRGTMQAQN-UHFFFAOYSA-N 156520 US9682966, 306::US10118915, Compound 306::US20250346584, Compound 306 Kappa-type opioid receptor Homo sapiens 107 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156520 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156520&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296774 355041613 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572770 Cc1noc(n1)-c1cc2cc(C)c(C)cc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C26H35N5O2/c1-16-11-19-13-22(26-27-18(3)30-33-26)25(29-24(19)12-17(16)2)31-10-9-23(20(14-31)15-32)28-21-7-5-4-6-8-21/h11-13,20-21,23,28,32H,4-10,14-15H2,1-3H3 BZFLXXPIFWRWBY-UHFFFAOYSA-N 156521 US9682966, 307::US10118915, Compound 307::US20250346584, Compound 307 Kappa-type opioid receptor Homo sapiens 41.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156521 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156521&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263876 355041614 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572771 COC1CN(CCC1NC1CCCC1)c1nc2ccccc2cc1-c1nc(C)no1 InChI=1S/C23H29N5O2/c1-15-24-23(30-27-15)18-13-16-7-3-6-10-19(16)26-22(18)28-12-11-20(21(14-28)29-2)25-17-8-4-5-9-17/h3,6-7,10,13,17,20-21,25H,4-5,8-9,11-12,14H2,1-2H3 VTQQKXYZFOIVDI-UHFFFAOYSA-N 156522 US9682966, 308::US10118915, Compound 308::US20250346584, Compound 308 Kappa-type opioid receptor Homo sapiens 2.50 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156522&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296776 355041615 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572772 COC1CN(CCC1NC1CCCC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C24H31N5O2/c1-15-8-9-20-17(12-15)13-19(24-25-16(2)28-31-24)23(27-20)29-11-10-21(22(14-29)30-3)26-18-6-4-5-7-18/h8-9,12-13,18,21-22,26H,4-7,10-11,14H2,1-3H3 RRLZMMNUJGBNDL-UHFFFAOYSA-N 156523 US9682966, 309::US10118915, Compound 309::US20250346584, Compound 309 Kappa-type opioid receptor Homo sapiens 0.500 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156523 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156523&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 73296772 355041616 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572773 CCc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(NC2CCCC2)C(C1)OC InChI=1S/C25H33N5O2/c1-4-23-28-25(32-29-23)19-14-17-13-16(2)9-10-20(17)27-24(19)30-12-11-21(22(15-30)31-3)26-18-7-5-6-8-18/h9-10,13-14,18,21-22,26H,4-8,11-12,15H2,1-3H3 DQOLJRAITBNCAU-UHFFFAOYSA-N 156524 US9682966, 310::US10118915, Compound 310::US20250346584, Compound 310 Kappa-type opioid receptor Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156524 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156524&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263877 355041617 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572774 COC1CN(CCC1NC1CCCCCC1)c1nc2ccccc2cc1-c1nc(C)no1 InChI=1S/C25H33N5O2/c1-17-26-25(32-29-17)20-15-18-9-7-8-12-21(18)28-24(20)30-14-13-22(23(16-30)31-2)27-19-10-5-3-4-6-11-19/h7-9,12,15,19,22-23,27H,3-6,10-11,13-14,16H2,1-2H3 CRWHFHKGYGKRGO-UHFFFAOYSA-N 156525 US9682966, 311::US10118915, Compound 311::US20250346584, Compound 311 Kappa-type opioid receptor Homo sapiens 1.000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156525 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156525&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263878 355041618 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572775 COC1CN(CCC1NC1CCCCCC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C26H35N5O2/c1-17-10-11-22-19(14-17)15-21(26-27-18(2)30-33-26)25(29-22)31-13-12-23(24(16-31)32-3)28-20-8-6-4-5-7-9-20/h10-11,14-15,20,23-24,28H,4-9,12-13,16H2,1-3H3 XMWRBMGKVCIHKF-UHFFFAOYSA-N 156526 US9682966, 312::US10118915, Compound 312::US20250346584, Compound 312 Kappa-type opioid receptor Homo sapiens 0.700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156526 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156526&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263880 355041619 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572776 CCc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCCC2)C(C1)OC InChI=1S/C27H37N5O2/c1-4-25-30-27(34-31-25)21-16-19-15-18(2)11-12-22(19)29-26(21)32-14-13-23(24(17-32)33-3)28-20-9-7-5-6-8-10-20/h11-12,15-16,20,23-24,28H,4-10,13-14,17H2,1-3H3 BHGQUOSIMOOYOS-UHFFFAOYSA-N 156529 US9682966, 313::US10118915, Compound 313::US20250346584, Compound 313 Kappa-type opioid receptor Homo sapiens 1.50 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156529 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156529&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263879 355041620 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572777 COC1CN(c2nc3ccc(C)cc3cc2C(=N)/N=C(/C)O)CCC1NC1CCCCC1 785803 US20250346584, Compound 314 Kappa-type opioid receptor Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785803 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785803&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572778 CO[C@@H]1CN(c2nc3ccc(C)cc3cc2/C(O)=N/C(C)=N)CC[C@@H]1NC1CCCCC1 785804 US20250346584, Compound 315 Kappa-type opioid receptor Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785804&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572779 COC1CN(CCC1NC1CCCC1)c1ncc(C)cc1-c1nc(C)no1 InChI=1S/C20H29N5O2/c1-13-10-16(20-22-14(2)24-27-20)19(21-11-13)25-9-8-17(18(12-25)26-3)23-15-6-4-5-7-15/h10-11,15,17-18,23H,4-9,12H2,1-3H3 QMGCLDBOJLVWCI-UHFFFAOYSA-N 156532 US9682966, 316::US10118915, Compound 316::US20250346584, Compound 316 Kappa-type opioid receptor Homo sapiens 23.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156532 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156532&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263883 355041623 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572780 COC1CN(CCC1NC1CCCC1)c1nc(C)c(C)cc1-c1nc(C)no1 InChI=1S/C21H31N5O2/c1-13-11-17(21-23-15(3)25-28-21)20(22-14(13)2)26-10-9-18(19(12-26)27-4)24-16-7-5-6-8-16/h11,16,18-19,24H,5-10,12H2,1-4H3 JRJOHFSLNLQIDJ-UHFFFAOYSA-N 156533 US9682966, 317::US10118915, Compound 317::US20250346584, Compound 317 Kappa-type opioid receptor Homo sapiens 27.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156533 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156533&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263885 355041624 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572781 COC1CN(CCC1NC1CCCCCC1)c1ncc(C)cc1-c1nc(C)no1 InChI=1S/C22H33N5O2/c1-15-12-18(22-24-16(2)26-29-22)21(23-13-15)27-11-10-19(20(14-27)28-3)25-17-8-6-4-5-7-9-17/h12-13,17,19-20,25H,4-11,14H2,1-3H3 XFFUIMPMXSBOED-UHFFFAOYSA-N 156534 US9682966, 318::US10118915, Compound 318::US20250346584, Compound 318 Kappa-type opioid receptor Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156534 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156534&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263886 355041625 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572782 COC1CN(CCC1NC1CCCCCC1)c1nc(C)c(C)cc1-c1nc(C)no1 InChI=1S/C23H35N5O2/c1-15-13-19(23-25-17(3)27-30-23)22(24-16(15)2)28-12-11-20(21(14-28)29-4)26-18-9-7-5-6-8-10-18/h13,18,20-21,26H,5-12,14H2,1-4H3 KQCWALSGFIAMMZ-UHFFFAOYSA-N 156535 US9682966, 319::US10118915, Compound 319::US20250346584, Compound 319 Kappa-type opioid receptor Homo sapiens 21.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156535 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156535&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263887 355041626 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572783 COC1CN(CCC1NC1CCOCC1)c1ncc(C)cc1-c1nc(C)no1 InChI=1S/C20H29N5O3/c1-13-10-16(20-22-14(2)24-28-20)19(21-11-13)25-7-4-17(18(12-25)26-3)23-15-5-8-27-9-6-15/h10-11,15,17-18,23H,4-9,12H2,1-3H3 AJRVDRRSYXGILM-UHFFFAOYSA-N 156536 US9682966, 320::US10118915, Compound 320::US20250346584, Compound 320 Kappa-type opioid receptor Homo sapiens 170 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156536 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156536&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263888 355041627 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572784 COC1CN(CCC1NC1CCOCC1)c1nc(C)c(C)cc1-c1nc(C)no1 InChI=1S/C21H31N5O3/c1-13-11-17(21-23-15(3)25-29-21)20(22-14(13)2)26-8-5-18(19(12-26)27-4)24-16-6-9-28-10-7-16/h11,16,18-19,24H,5-10,12H2,1-4H3 JCHVCPCOTUMGEY-UHFFFAOYSA-N 156537 US9682966, 321::US10118915, Compound 321::US20250346584, Compound 321 Kappa-type opioid receptor Homo sapiens 105 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156537 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156537&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263889 355041628 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572785 COC1CN(CCC1NC1CCOCC1)C(\N)=C(\C=C(\C)N)/c1nc(C)no1 InChI=1S/C19H32N6O3/c1-12(20)10-15(19-22-13(2)24-28-19)18(21)25-7-4-16(17(11-25)26-3)23-14-5-8-27-9-6-14/h10,14,16-17,23H,4-9,11,20-21H2,1-3H3 JDOPJHJGZGJJAY-UHFFFAOYSA-N 156538 US9682966, 322::US20250346584, Compound 322 Kappa-type opioid receptor Homo sapiens 16.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156538 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156538&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263891 355041629 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572786 COC1CN(CCC1NC1CCCCC1)c1nc2ccc(C)cc2cc1C(=O)N1CCCC1 InChI=1S/C27H38N4O2/c1-19-10-11-23-20(16-19)17-22(27(32)30-13-6-7-14-30)26(29-23)31-15-12-24(25(18-31)33-2)28-21-8-4-3-5-9-21/h10-11,16-17,21,24-25,28H,3-9,12-15,18H2,1-2H3 JANACMZRWXADBV-UHFFFAOYSA-N 156539 US9682966, 323::US10118915, Compound 323::US20250346584, Compound 323 Kappa-type opioid receptor Homo sapiens 1340 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156539 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156539&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263890 355041630 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572787 CC(C)CNC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C22H29N5O/c1-14(2)13-23-18-7-9-27(10-8-18)21-19(22-24-16(4)26-28-22)12-17-11-15(3)5-6-20(17)25-21/h5-6,11-12,14,18,23H,7-10,13H2,1-4H3 GIXQPNRFKDSHSF-UHFFFAOYSA-N 156541 US9682966, 324::US10118915, Compound 324::US20250346584, Compound 324 Kappa-type opioid receptor Homo sapiens 1.30 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156541&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263892 355041631 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572788 COC1CN(CCC1NC1CCOCC1)c1nc2ccccc2cc1-c1nc(C)no1 InChI=1S/C23H29N5O3/c1-15-24-23(31-27-15)18-13-16-5-3-4-6-19(16)26-22(18)28-10-7-20(21(14-28)29-2)25-17-8-11-30-12-9-17/h3-6,13,17,20-21,25H,7-12,14H2,1-2H3 YHLQNTZXWCJPBB-UHFFFAOYSA-N 156542 US9682966, 325::US10118915, Compound 325::US20250346584, Compound 325 Kappa-type opioid receptor Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156542 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156542&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263893 355041632 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572789 COC1CN(CCC1NC1CCOCC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C24H31N5O3/c1-15-4-5-20-17(12-15)13-19(24-25-16(2)28-32-24)23(27-20)29-9-6-21(22(14-29)30-3)26-18-7-10-31-11-8-18/h4-5,12-13,18,21-22,26H,6-11,14H2,1-3H3 QPTLSLJLZSPXTO-UHFFFAOYSA-N 156544 US9682966, 326::US10118915, Compound 326::US20250346584, Compound 326 Kappa-type opioid receptor Homo sapiens 1.90 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156544 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156544&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263895 355041633 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572790 CCc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(NC2CCOCC2)C(C1)OC InChI=1S/C25H33N5O3/c1-4-23-28-25(33-29-23)19-14-17-13-16(2)5-6-20(17)27-24(19)30-10-7-21(22(15-30)31-3)26-18-8-11-32-12-9-18/h5-6,13-14,18,21-22,26H,4,7-12,15H2,1-3H3 UZSUOZQITIHVDC-UHFFFAOYSA-N 156546 US9682966, 327::US10118915, Compound 327::US20250346584, Compound 327 Kappa-type opioid receptor Homo sapiens 5.60 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156546 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156546&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263894 355041634 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572791 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 785817 US20250346584, Compound 328 Kappa-type opioid receptor Homo sapiens 0.720 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785817&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572792 CO[C@@H]1CN(c2nc3ccccc3cc2/C(O)=N/C(C)=N)CC[C@@H]1NC1CCCCC1 785818 US20250346584, Compound 329 Kappa-type opioid receptor Homo sapiens 12.2 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785818&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572793 CCC(=N)/N=C(\O)c1cc2cc(C)ccc2nc1N1CC[C@H](NC2CCCCC2)[C@H](OC)C1 785819 US20250346584, Compound 330 Kappa-type opioid receptor Homo sapiens 4.90 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785819&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572794 CO[C@@H]1CN(c2nc3ccc(F)cc3cc2/C(O)=N/C(C)=N)CC[C@@H]1NC1CCCCC1 785820 US20250346584, Compound 331 Kappa-type opioid receptor Homo sapiens 27.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785820&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572795 Cc1nc(no1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C23H29N5O2/c1-15-3-4-21-17(13-15)14-20(22-24-16(2)30-27-22)23(26-21)28-9-5-18(6-10-28)25-19-7-11-29-12-8-19/h3-4,13-14,18-19,25H,5-12H2,1-2H3 LKIAPNMPWGXCAF-UHFFFAOYSA-N 156551 US9682966, 332::US10118915, Compound 332::US20250346584, Compound 332 Kappa-type opioid receptor Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156551 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156551&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263899 355041639 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572796 CO[C@H]1CN(c2nc3ccccc3nc2/C(O)=N/C(C)=N)CC[C@H]1NC1CCCCC1 785822 US20250346584, Compound 333 Kappa-type opioid receptor Homo sapiens 6.60 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785822&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572797 CO[C@@H]1CN(c2nc3ccccc3nc2/C(O)=N/C(C)=N)CC[C@@H]1NC1CCCCC1 785823 US20250346584, Compound 334 Kappa-type opioid receptor Homo sapiens 161 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785823&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572798 CCC(=N)/N=C(\O)c1cc2cc(C)ccc2nc1N1CC[C@@H](NC2CCCCC2)[C@H](OC)C1 785824 US20250346584, Compound 335 Kappa-type opioid receptor Homo sapiens 113 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785824&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572799 CCOC(=O)c1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C27H35N5O4/c1-3-35-27(34)24-30-26(36-31-24)21-14-18-13-17(2)9-10-22(18)29-25(21)32-12-11-23(19(15-32)16-33)28-20-7-5-4-6-8-20/h9-10,13-14,19-20,23,28,33H,3-8,11-12,15-16H2,1-2H3 LEWGVSZOLJKKSJ-UHFFFAOYSA-N 156555 US9682966, C91::US10118915, Compound C91::US20250346584, Compound C91 Kappa-type opioid receptor Homo sapiens 17700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156555 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156555&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263904 355041643 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572800 CCOC(=O)c1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCCC1O InChI=1S/C26H33N5O4/c1-3-34-26(33)23-29-25(35-30-23)19-15-17-14-16(2)8-9-20(17)28-24(19)31-12-10-18(11-13-31)27-21-6-4-5-7-22(21)32/h8-9,14-15,18,21-22,27,32H,3-7,10-13H2,1-2H3 CWJVYOMVODSTQH-UHFFFAOYSA-N 156556 US9682966, 336::US10118915, Compound 336::US20250346584, Compound 336 Kappa-type opioid receptor Homo sapiens 4360 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156556 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156556&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263905 355041644 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572801 CO[C@H]1CN(c2nc3ccc(C)cc3cc2/C(O)=N/C(=N)C2CC2)CC[C@H]1NC1CCCCC1 785827 US20250346584, Compound 337 Kappa-type opioid receptor Homo sapiens 0.730 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785827&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572802 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccc(C)cc2cc1-c1noc(C)n1 |r| InChI=1S/C25H33N5O2/c1-16-9-10-21-18(13-16)14-20(24-26-17(2)32-29-24)25(28-21)30-12-11-22(23(15-30)31-3)27-19-7-5-4-6-8-19/h9-10,13-14,19,22-23,27H,4-8,11-12,15H2,1-3H3 XDWKZQHDFKSQPY-UHFFFAOYSA-N 156558 US9682966, 338::US10118915, Compound 338::US20250346584, Compound 338 Kappa-type opioid receptor Homo sapiens 0.990 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156558&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263908 355041646 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572803 CO[C@H]1CN(c2ncc(C)cc2/C(O)=N/C(C)=N)CC[C@H]1N(C1CCCC1)C1CCCC1 785829 US20250346584, Compound 339 Kappa-type opioid receptor Homo sapiens 29.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785829&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572804 CO[C@@H]1CN(c2nc3ccc(C)cc3cc2/C(O)=N/C(=N)C2CC2)CC[C@@H]1NC1CCCC1 785830 US20250346584, Compound 340 Kappa-type opioid receptor Homo sapiens 6.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785830 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785830&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572805 CO[C@@H]1CN(c2ncc(C)cc2/C(O)=N/C(C)=N)CC[C@@H]1NC1CCCCC1 785831 US20250346584, Compound 341 Kappa-type opioid receptor Homo sapiens 76.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785831&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572806 CO[C@@H]1CN(c2nc(C)c(C)cc2/C(O)=N/C(C)=N)CC[C@@H]1NC1CCCCC1 785832 US20250346584, Compound 342 Kappa-type opioid receptor Homo sapiens 48.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785832 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785832&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572807 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccc(C)cc2cc1C(=O)OC(C)C |r| InChI=1S/C26H37N3O3/c1-17(2)32-26(30)21-15-19-14-18(3)10-11-22(19)28-25(21)29-13-12-23(24(16-29)31-4)27-20-8-6-5-7-9-20/h10-11,14-15,17,20,23-24,27H,5-9,12-13,16H2,1-4H3 CLRXGWFAQYJWRY-UHFFFAOYSA-N 156563 US9682966, 343::US10118915, Compound 343::US20250346584, Compound 343 Kappa-type opioid receptor Homo sapiens 10.6 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156563&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263910 355041651 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572808 CO[C@H]1CN(c2nc3ccccc3cc2C(=N)/C=C\C(C)=N)CC[C@H]1NC1CCCCC1 785834 US20250346584, Compound 344 Kappa-type opioid receptor Homo sapiens 16.8 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785834&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572809 CO[C@@H]1CN(c2ncc(C)cc2/C(O)=N/C(C)=N)CC[C@@H]1NC1CCCC1 785835 US20250346584, Compound 345 Kappa-type opioid receptor Homo sapiens 104 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785835 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785835&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572810 CO[C@@H]1CN(c2nc(C)c(C)cc2/C(O)=N/C(C)=N)CC[C@@H]1NC1CCCC1 785836 US20250346584, Compound 346 Kappa-type opioid receptor Homo sapiens 137 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785836 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785836&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572811 CO[C@@H]1CN(c2nc3ccc(C)cc3cc2/C(O)=N/C(C)=N)CC[C@@H]1NC1CCCC1 785837 US20250346584, Compound 347 Kappa-type opioid receptor Homo sapiens 32.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785837&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572812 CC1CCCCC1NC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C25H33N5O/c1-16-8-9-23-19(14-16)15-21(25-26-18(3)29-31-25)24(28-23)30-12-10-20(11-13-30)27-22-7-5-4-6-17(22)2/h8-9,14-15,17,20,22,27H,4-7,10-13H2,1-3H3 PTRMMTANCHZTKY-UHFFFAOYSA-N 156568 US9682966, 348::US10118915, Compound 348::US20250346584, Compound 348 Kappa-type opioid receptor Homo sapiens 1.30 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156568&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263919 355041656 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572813 CC(NC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1)C1CCCCC1 InChI=1S/C26H35N5O/c1-17-9-10-24-21(15-17)16-23(26-28-19(3)30-32-26)25(29-24)31-13-11-22(12-14-31)27-18(2)20-7-5-4-6-8-20/h9-10,15-16,18,20,22,27H,4-8,11-14H2,1-3H3 RGITZSAHKSYMHF-UHFFFAOYSA-N 156569 US9682966, 349::US10118915, Compound 349::US20250346584, Compound 349 Kappa-type opioid receptor Homo sapiens 21.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156569&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263916 355041657 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572814 CC1CCC(CC1)NC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 |(8.67,-.62,;7.34,-1.39,;7.34,-2.93,;6,-3.7,;4.67,-2.93,;4.67,-1.39,;6,-.62,;3.33,-3.7,;2,-2.93,;.67,-3.7,;-.67,-2.93,;-.67,-1.39,;.67,-.62,;2,-1.39,;-2,-.62,;-3.33,-1.39,;-4.67,-.62,;-6,-1.39,;-7.34,-.62,;-7.34,.92,;-8.67,1.69,;-6,1.69,;-4.67,.92,;-3.33,1.69,;-2,.92,;-.67,1.69,;.8,1.21,;1.7,2.46,;3.24,2.46,;.8,3.7,;-.67,3.23,)| InChI=1S/C25H33N5O/c1-16-4-7-20(8-5-16)27-21-10-12-30(13-11-21)24-22(25-26-18(3)29-31-25)15-19-14-17(2)6-9-23(19)28-24/h6,9,14-16,20-21,27H,4-5,7-8,10-13H2,1-3H3 UKJVRBJBSJSTAE-UHFFFAOYSA-N 156570 US9682966, 350::US10118915, Compound 350::US20250346584, Compound 350 Kappa-type opioid receptor Homo sapiens 0.970 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156570&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263918 355041658 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572815 CCCC(C)NC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C23H31N5O/c1-5-6-16(3)24-19-9-11-28(12-10-19)22-20(23-25-17(4)27-29-23)14-18-13-15(2)7-8-21(18)26-22/h7-8,13-14,16,19,24H,5-6,9-12H2,1-4H3 DMHUWOQCWSWOEZ-UHFFFAOYSA-N 156571 US9682966, 351::US10118915, Compound 351::US20250346584, Compound 351 Kappa-type opioid receptor Homo sapiens 3.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156571&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263920 355041659 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572816 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NCC1CCCCC1O InChI=1S/C25H33N5O2/c1-16-7-8-22-19(13-16)14-21(25-27-17(2)29-32-25)24(28-22)30-11-9-20(10-12-30)26-15-18-5-3-4-6-23(18)31/h7-8,13-14,18,20,23,26,31H,3-6,9-12,15H2,1-2H3 JLCCCFVVLQAXBU-UHFFFAOYSA-N 156572 US9682966, 352::US10118915, Compound 352::US20250346584, Compound 352 Kappa-type opioid receptor Homo sapiens 3.10 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156572&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263921 355041660 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572817 CCOC(=O)c1nc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(C1)OC InChI=1S/C24H34N4O3/c1-4-31-24(29)22-23(27-18-11-10-16(2)14-20(18)26-22)28-13-12-19(21(15-28)30-3)25-17-8-6-5-7-9-17/h10-11,14,17,19,21,25H,4-9,12-13,15H2,1-3H3 MADZTZMDILZHMB-UHFFFAOYSA-N 156573 US9682966, 353::US10118915, Compound 353::US20250346584, Compound 353 Kappa-type opioid receptor Homo sapiens 23.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156573&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263922 355041661 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572818 CC(C)CNC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(no1)C1CC1 InChI=1S/C24H31N5O/c1-15(2)14-25-19-8-10-29(11-9-19)23-20(24-27-22(28-30-24)17-5-6-17)13-18-12-16(3)4-7-21(18)26-23/h4,7,12-13,15,17,19,25H,5-6,8-11,14H2,1-3H3 SQXDWFJLQKSWOE-UHFFFAOYSA-N 156574 US9682966, 354::US10118915, Compound 354::US20250346584, Compound 354 Kappa-type opioid receptor Homo sapiens 4.20 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156574&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263925 355041662 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572819 CCc1ccc2nc(N3CCC(CC3)NCC(C)C)c(cc2c1)-c1nc(C)no1 InChI=1S/C23H31N5O/c1-5-17-6-7-21-18(12-17)13-20(23-25-16(4)27-29-23)22(26-21)28-10-8-19(9-11-28)24-14-15(2)3/h6-7,12-13,15,19,24H,5,8-11,14H2,1-4H3 JTFHVEYAVQAEGK-UHFFFAOYSA-N 156575 US9682966, 355::US10118915, Compound 355::US20250346584, Compound 355 Kappa-type opioid receptor Homo sapiens 1.20 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156575&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263923 355041663 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572820 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1ncc(C)cc1C(=O)OC(C)C |r| InChI=1S/C22H35N3O3/c1-15(2)28-22(26)18-12-16(3)13-23-21(18)25-11-10-19(20(14-25)27-4)24-17-8-6-5-7-9-17/h12-13,15,17,19-20,24H,5-11,14H2,1-4H3 UCFAJTQTZBCVLM-UHFFFAOYSA-N 156576 US9682966, 356::US10118915, Compound 356::US20250346584, Compound 356 Kappa-type opioid receptor Homo sapiens 12.5 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156576&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263924 355041664 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572821 Cc1noc(n1)-c1cc(C)cnc1N1CCC(C)(CC1)NC1CCCCC1 InChI=1S/C21H31N5O/c1-15-13-18(20-23-16(2)25-27-20)19(22-14-15)26-11-9-21(3,10-12-26)24-17-7-5-4-6-8-17/h13-14,17,24H,4-12H2,1-3H3 RKAZUFFIXVGYPR-UHFFFAOYSA-N 156577 US9682966, 357::US10118915, Compound 357::US20250346584, Compound 357 Kappa-type opioid receptor Homo sapiens 22.3 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156577&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263926 355041665 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572822 COC1CN(c2ncc(C)cc2N/C=C\C(C)=N)CCC1NC1CCCCC1 785848 US20250346584, Compound 358 Kappa-type opioid receptor Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785848&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572823 COC1CN(c2ncc(C)cc2N/C=C(/C)C=N)CCC1NC1CCCCC1 785849 US20250346584, Compound C92 Kappa-type opioid receptor Homo sapiens 58000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785849&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572824 CO[C@H]1CN(c2ncc(C)cc2C(=N)/C=C\C(C)=N)CC[C@H]1NC1CCCCC1 785850 US20250346584, Compound 359 Kappa-type opioid receptor Homo sapiens 160 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785850&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572825 CC(=N)/C=C\C(=N)c1cc(C)cnc1N1CCC(NCC(C)C)CC1 785851 US20250346584, Compound C93 Kappa-type opioid receptor Homo sapiens 10181 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785851&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572826 CC(O)CNC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C21H27N5O2/c1-13-4-5-19-16(10-13)11-18(21-23-15(3)25-28-21)20(24-19)26-8-6-17(7-9-26)22-12-14(2)27/h4-5,10-11,14,17,22,27H,6-9,12H2,1-3H3 HGVDPSLWTCEZOP-UHFFFAOYSA-N 156582 US9682966, 360::US10118915, Compound 360::US20250346584, Compound 360 Kappa-type opioid receptor Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156582&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263931 355041670 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572827 CO[C@@H]1CN(CC[C@@H]1NC1CCCCC1)c1ncc(C)cc1C(=O)OC(C)C |r| InChI=1S/C22H35N3O3/c1-15(2)28-22(26)18-12-16(3)13-23-21(18)25-11-10-19(20(14-25)27-4)24-17-8-6-5-7-9-17/h12-13,15,17,19-20,24H,5-11,14H2,1-4H3 UCFAJTQTZBCVLM-UHFFFAOYSA-N 156583 US9682966, 361::US10118915, Compound 361::US20250346584, Compound 361 Kappa-type opioid receptor Homo sapiens 1440 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156583&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263932 355041671 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572828 CO[C@H]1CN(c2nc3c(C)cc(C)cc3cc2/C(O)=N/C(C)=N)CC[C@H]1NC1CCCCC1 785854 US20250346584, Compound 362 Kappa-type opioid receptor Homo sapiens 3.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785854&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572829 CC(=N)/N=C(\O)c1cc2cc(C)cc(C)c2nc1N1CCC(NC2CCOCC2)CC1 785855 US20250346584, Compound 363 Kappa-type opioid receptor Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785855&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572830 CC(=N)/N=C(\O)c1cc2cc(C)cc(C)c2nc1N1CCC(NCC(C)C)CC1 785856 US20250346584, Compound 364 Kappa-type opioid receptor Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785856&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572831 COC1CN(c2nc3c(C)cc(C)cc3cc2/C(O)=N/C(C)=N)CCC1NCC(C)C 785857 US20250346584, Compound 365 Kappa-type opioid receptor Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785857&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572832 CO[C@H]1CN(c2ncc(C)cc2N/C=C\C(C)=N)CC[C@H]1NC1CCCCC1 785858 US20250346584, Compound 366 Kappa-type opioid receptor Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785858 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785858&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572833 CC(=N)/N=C(\O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCCC2)CC1 785859 US20250346584, Compound 367 Kappa-type opioid receptor Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785859&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572834 CC(=N)/N=C(\O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2CO)CC1 785860 US20250346584, Compound 368 Kappa-type opioid receptor Homo sapiens 7.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785860 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785860&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572835 CC(=N)/N=C(\O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCC2)CC1 785861 US20250346584, Compound 369 Kappa-type opioid receptor Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785861 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785861&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572836 CC(=N)/N=C(\O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCC2)CC1 785862 US20250346584, Compound 370 Kappa-type opioid receptor Homo sapiens 37.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785862 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785862&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572837 CC(=N)/N=C(\O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2O)CC1 785863 US20250346584, Compound 371 Kappa-type opioid receptor Homo sapiens 1.000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785863&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572838 CC(=N)/N=C(\O)c1cc2cc(C)ccc2nc1N1CCC(NC2CCC[C@@H]2O)CC1 785864 US20250346584, Compound 372 Kappa-type opioid receptor Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785864 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785864&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572839 CCOC(=O)c1nc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)C(CO)C1 InChI=1S/C24H34N4O3/c1-3-31-24(30)22-23(27-20-10-9-16(2)13-21(20)26-22)28-12-11-19(17(14-28)15-29)25-18-7-5-4-6-8-18/h9-10,13,17-19,25,29H,3-8,11-12,14-15H2,1-2H3 VEORGNPABCPNLK-UHFFFAOYSA-N 156595 US9682966, 373::US10118915, Compound 373::US20250346584, Compound 373 Kappa-type opioid receptor Homo sapiens 63.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156595 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156595&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263945 355041682 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572840 COC1CN(CCC1NCC(C)C)c1nc2ccccc2cc1-c1nc(C)no1 InChI=1S/C22H29N5O2/c1-14(2)12-23-19-9-10-27(13-20(19)28-4)21-17(22-24-15(3)26-29-22)11-16-7-5-6-8-18(16)25-21/h5-8,11,14,19-20,23H,9-10,12-13H2,1-4H3 CVLFLFWWUNMKCL-UHFFFAOYSA-N 156596 US9682966, 374::US10118915, Compound 374::US20250346584, Compound 374 Kappa-type opioid receptor Homo sapiens 45.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156596 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156596&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263943 355041683 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572841 COC1CN(CCC1NCC(C)C)c1nc2ccc(C)cc2cc1-c1nc(C)no1 InChI=1S/C23H31N5O2/c1-14(2)12-24-20-8-9-28(13-21(20)29-5)22-18(23-25-16(4)27-30-23)11-17-10-15(3)6-7-19(17)26-22/h6-7,10-11,14,20-21,24H,8-9,12-13H2,1-5H3 SXXOZDYJQYJAAX-UHFFFAOYSA-N 156597 US9682966, 375::US10118915, Compound 375::US20250346584, Compound 375 Kappa-type opioid receptor Homo sapiens 12.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156597&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263946 355041684 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572842 COC1CN(CCC1NCC(C)C)c1nc2ccc(C)cc2cc1-c1nc(no1)C1CC1 InChI=1S/C25H33N5O2/c1-15(2)13-26-21-9-10-30(14-22(21)31-4)24-19(25-28-23(29-32-25)17-6-7-17)12-18-11-16(3)5-8-20(18)27-24/h5,8,11-12,15,17,21-22,26H,6-7,9-10,13-14H2,1-4H3 PKQXVZMUMPXMEP-UHFFFAOYSA-N 156598 US9682966, 376::US10118915, Compound 376::US20250346584, Compound 376 Kappa-type opioid receptor Homo sapiens 14.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156598 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156598&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263947 355041685 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572843 COC1CN(CCC1NCC(C)C)c1nc2ccc(C)cc2cc1-c1noc(C)n1 InChI=1S/C23H31N5O2/c1-14(2)12-24-20-8-9-28(13-21(20)29-5)23-18(22-25-16(4)30-27-22)11-17-10-15(3)6-7-19(17)26-23/h6-7,10-11,14,20-21,24H,8-9,12-13H2,1-5H3 IVUWUCIIIBKUFF-UHFFFAOYSA-N 156599 US9682966, 377::US10118915, Compound 377::US20250346584, Compound 377 Kappa-type opioid receptor Homo sapiens 69.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156599 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156599&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263948 355041686 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572844 COC1CN(CCC1NCC(C)C)c1nc(C)c(C)cc1-c1nc(C)no1 InChI=1S/C20H31N5O2/c1-12(2)10-21-17-7-8-25(11-18(17)26-6)19-16(9-13(3)14(4)22-19)20-23-15(5)24-27-20/h9,12,17-18,21H,7-8,10-11H2,1-6H3 UTQQZKVJNBBEFB-UHFFFAOYSA-N 156600 US9682966, 378::US10118915, Compound 378::US20250346584, Compound 378 Kappa-type opioid receptor Homo sapiens 256 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156600&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263949 355041687 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572845 CCc1cnc(N2CCC(NC3CCCCC3)C(OC)C2)c(/C(O)=N/C(C)=N)c1 785871 US20250346584, Compound 379 Kappa-type opioid receptor Homo sapiens 525 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785871 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785871&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572846 COC1CN(c2ncc(C)cc2/C(O)=C/C(C)=N)CCC1NC1CCCCC1 785872 US20250346584, Compound 380 Kappa-type opioid receptor Homo sapiens 128 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785872&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572847 CC(=N)/C=C(\O)c1cc(C)cnc1N1CCC(NCC(C)C)CC1 785873 US20250346584, Compound 381 Kappa-type opioid receptor Homo sapiens 860 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785873 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785873&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572848 CO[C@@H]1CN(CC[C@@H]1NC1CCCCC1)c1nc2ccc(C)cc2cc1-c1noc(C)n1 |r| InChI=1S/C25H33N5O2/c1-16-9-10-21-18(13-16)14-20(24-26-17(2)32-29-24)25(28-21)30-12-11-22(23(15-30)31-3)27-19-7-5-4-6-8-19/h9-10,13-14,19,22-23,27H,4-8,11-12,15H2,1-3H3 XDWKZQHDFKSQPY-UHFFFAOYSA-N 156604 US9682966, 382::US10118915, Compound 382::US20250346584, Compound 382 Kappa-type opioid receptor Homo sapiens 83.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156604&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263953 355041691 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572849 CO[C@@H]1CN(c2ncc(C)cc2N/C=C\C(C)=N)CC[C@@H]1NC1CCCCC1 785875 US20250346584, Compound 383 Kappa-type opioid receptor Homo sapiens 1161 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785875 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785875&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572850 COC1CN(CCC1NC1CCCCC1)c1ncc(C)cc1-c1nccc(C)n1 InChI=1S/C23H33N5O/c1-16-13-19(22-24-11-9-17(2)26-22)23(25-14-16)28-12-10-20(21(15-28)29-3)27-18-7-5-4-6-8-18/h9,11,13-14,18,20-21,27H,4-8,10,12,15H2,1-3H3 ZFWTVJRYHRHYNF-UHFFFAOYSA-N 156606 US9682966, 384::US10118915, Compound 384::US20250346584, Compound 384 Kappa-type opioid receptor Homo sapiens 16700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156606&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263956 355041693 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572851 CC(C)OC(=O)\C(\C=C(\C)N)=C(\N)N1CCC(CC1)NC1CCCCC1 InChI=1S/C20H36N4O2/c1-14(2)26-20(25)18(13-15(3)21)19(22)24-11-9-17(10-12-24)23-16-7-5-4-6-8-16/h13-14,16-17,23H,4-12,21-22H2,1-3H3 PALCRFZDXBQOQS-UHFFFAOYSA-N 156607 US9682966, 385::US20250346584, Compound 385 Kappa-type opioid receptor Homo sapiens 1.000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156607&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263955 355041694 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572852 CC(=N)/N=C(\O)c1ccc(C)nc1N1CCC(NC2CCCCC2)C(CO)C1 785878 US20250346584, Compound 386 Kappa-type opioid receptor Homo sapiens 31.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785878&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572853 CC(=N)/N=C(\O)c1ccc(C)nc1N1CCC(NC2CCCCC2)CC1 785879 US20250346584, Compound 387 Kappa-type opioid receptor Homo sapiens 89.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785879&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572854 CC(=N)/N=C(\O)c1cc(C)cnc1N1CCC(NC2CCCCC2)CC1 785880 US20250346584, Compound 388 Kappa-type opioid receptor Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785880&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572855 CC(=N)/N=C(\O)c1cc(C)cnc1N1CCC(NC2CCOCC2)CC1 785881 US20250346584, Compound 389 Kappa-type opioid receptor Homo sapiens 153 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785881&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572856 COC1CN(CCC1NC1CCCCC1)c1nc(C)c(C)nc1-c1nc(C)no1 InChI=1S/C21H32N6O2/c1-13-14(2)23-20(19(22-13)21-24-15(3)26-29-21)27-11-10-17(18(12-27)28-4)25-16-8-6-5-7-9-16/h16-18,25H,5-12H2,1-4H3 RODVEVYKICXFIX-UHFFFAOYSA-N 156612 US9682966, 390::US10118915, Compound 390::US20250346584, Compound 390 Kappa-type opioid receptor Homo sapiens 1920 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156612 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156612&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263961 355041699 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572857 CCC(=N)/N=C(\O)c1cc(C)cnc1N1CCC(NC2CCCCC2)C(OC)C1 785883 US20250346584, Compound 391 Kappa-type opioid receptor Homo sapiens 105 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785883 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785883&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572858 COC1CN(CCC1NC1CCCCC1)c1ncc(C)cc1-c1cn(C)nn1 InChI=1S/C21H32N6O/c1-15-11-17(19-13-26(2)25-24-19)21(22-12-15)27-10-9-18(20(14-27)28-3)23-16-7-5-4-6-8-16/h11-13,16,18,20,23H,4-10,14H2,1-3H3 OXXQSAHCHXEDFJ-UHFFFAOYSA-N 156614 US9682966, 392::US10118915, Compound 392::US20250346584, Compound 392 Kappa-type opioid receptor Homo sapiens 2960 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156614&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 129252282 355041701 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572859 CC(=N)/N=C(\O)c1cc(C)cnc1N1CCC(NCC(C)C)CC1 785885 US20250346584, Compound 393 Kappa-type opioid receptor Homo sapiens 346 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785885 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785885&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572860 CC(=N)/N=C(\O)c1cc(C)c(C)nc1N1CCC(NCC(C)C)CC1 785886 US20250346584, Compound 394 Kappa-type opioid receptor Homo sapiens 161 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785886&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572861 CO[C@H]1CN(c2ncc(C)cc2C(=N)/N=C(/C)O)CC[C@H]1NC1CCCCC1 785887 US20250346584, Compound 395 Kappa-type opioid receptor Homo sapiens 49.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785887&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572862 Cc1cnc(N2CCC(NC3CCOCC3)CC2)c(/C(O)=N/C(=N)C2CC2)c1 785888 US20250346584, Compound 396 Kappa-type opioid receptor Homo sapiens 2263 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785888&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572863 Cc1cnc(N2CCC(NCC(C)C)CC2)c(/C(O)=N/C(=N)C2CC2)c1 785889 US20250346584, Compound 397 Kappa-type opioid receptor Homo sapiens 1280 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785889&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572864 CO[C@H]1CN(c2ncc(C)cc2/C(O)=N/C(=N)C2CC2)CC[C@H]1NC1CCCCC1 785890 US20250346584, Compound 398 Kappa-type opioid receptor Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785890&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572865 CO[C@@H]1CN(c2ncc(C)cc2C(=N)/N=C(/C)O)CC[C@@H]1NC1CCCCC1 785891 US20250346584, Compound 399 Kappa-type opioid receptor Homo sapiens 953 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785891&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572866 C/C(N)=C/C(C(=O)N(C)C)=C(\N)N1CCC(NC2CCCCC2)CC1 785892 US20250346584, Compound 400 Kappa-type opioid receptor Homo sapiens 279 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785892&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572867 COC1CN(CCC1NC1CCCCC1)C(\N)=C(\C=C(\C)N)/C(=O)N(C)C InChI=1S/C20H37N5O2/c1-14(21)12-16(20(26)24(2)3)19(22)25-11-10-17(18(13-25)27-4)23-15-8-6-5-7-9-15/h12,15,17-18,23H,5-11,13,21-22H2,1-4H3 JAKSWLCPKUSNCW-UHFFFAOYSA-N 156629 US9682966, 401::US20250346584, Compound 401 Kappa-type opioid receptor Homo sapiens 67.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156629 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156629&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263974 355041710 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572868 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NCC(C)(C)O InChI=1S/C22H29N5O2/c1-14-5-6-19-16(11-14)12-18(21-24-15(2)26-29-21)20(25-19)27-9-7-17(8-10-27)23-13-22(3,4)28/h5-6,11-12,17,23,28H,7-10,13H2,1-4H3 MJXHGIWBAABJCU-UHFFFAOYSA-N 156630 US9682966, 402::US10118915, Compound 402::US20250346584, Compound 402 Kappa-type opioid receptor Homo sapiens 16.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156630 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156630&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263973 355041711 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572869 CC(C)OC(=O)\C(\C=C(\C)N)=C(\N)N1CCC(CC1)NCC(C)(C)O InChI=1S/C18H34N4O3/c1-12(2)25-17(23)15(10-13(3)19)16(20)22-8-6-14(7-9-22)21-11-18(4,5)24/h10,12,14,21,24H,6-9,11,19-20H2,1-5H3 YKVVRZWDXKQPHT-UHFFFAOYSA-N 156631 US9682966, 403::US20250346584, Compound 403 Kappa-type opioid receptor Homo sapiens 322 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156631 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156631&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263972 355041712 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572870 CO[C@@H]1CN(CC[C@@H]1NC1CCCCC1)C(\N)=C(\C=C(\C)N)/C(=O)OC(C)C |r| InChI=1S/C21H38N4O3/c1-14(2)28-21(26)17(12-15(3)22)20(23)25-11-10-18(19(13-25)27-4)24-16-8-6-5-7-9-16/h12,14,16,18-19,24H,5-11,13,22-23H2,1-4H3 HBOXYLUJCBJXAV-UHFFFAOYSA-N 156633 US9682966, 404::US20250346584, Compound 404 Kappa-type opioid receptor Homo sapiens 63.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156633 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156633&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263976 355041713 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572871 CO[C@@H]1CN(CC[C@H]1NC1CCCCC1)c1ncc(C)cc1C(=N)\C=C/C(C)=N |r| InChI=1S/C23H35N5O/c1-16-13-19(20(25)10-9-17(2)24)23(26-14-16)28-12-11-21(22(15-28)29-3)27-18-7-5-4-6-8-18/h9-10,13-14,18,21-22,24-25,27H,4-8,11-12,15H2,1-3H3 JECGVYCEDRDDQO-UHFFFAOYSA-N 156634 US9682966, 405::US20250346584, Compound 405 Kappa-type opioid receptor Homo sapiens 21400 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156634 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156634&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263975 355041714 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572872 Cc1cnc(nc1)-c1cc(C)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C22H31N5/c1-16-12-20(21-23-14-17(2)15-24-21)22(25-13-16)27-10-8-19(9-11-27)26-18-6-4-3-5-7-18/h12-15,18-19,26H,3-11H2,1-2H3 QJMIMDGPHOAZCB-UHFFFAOYSA-N 156636 US9682966, 406::US10118915, Compound 406::US20250346584, Compound 406 Kappa-type opioid receptor Homo sapiens 7680 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156636 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156636&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263977 355041715 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572873 CCOC(=O)CCNC1CCN(c2nc3ccc(C)cc3cc2/C(O)=N/C(C)=N)CC1 785899 US20250346584, Compound 407 Kappa-type opioid receptor Homo sapiens 341 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785899&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572874 COC1CN(CCC1NCC(C)C)C(\N)=C(\C=C(\C)N)/C(=O)OC(C)C InChI=1S/C19H36N4O3/c1-12(2)10-22-16-7-8-23(11-17(16)25-6)18(21)15(9-14(5)20)19(24)26-13(3)4/h9,12-13,16-17,22H,7-8,10-11,20-21H2,1-6H3 HQVOPOMKUMYFIS-UHFFFAOYSA-N 156638 US9682966, 408::US20250346584, Compound 408 Kappa-type opioid receptor Homo sapiens 57.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156638 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156638&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263979 355041717 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572875 CC(C)OC(=O)\C(\C=C(\C)N)=C(\N)N1CCC(CC1)NC1CCOCC1 InChI=1S/C19H34N4O3/c1-13(2)26-19(24)17(12-14(3)20)18(21)23-8-4-15(5-9-23)22-16-6-10-25-11-7-16/h12-13,15-16,22H,4-11,20-21H2,1-3H3 VHXUDPYEKJHATD-UHFFFAOYSA-N 156640 US9682966, 409::US20250346584, Compound 409 Kappa-type opioid receptor Homo sapiens 129 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156640 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156640&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263980 355041718 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572876 CC(C)CNC1CCN(CC1)C(\N)=C(\C=C(\C)N)/C(=O)OC(C)C InChI=1S/C18H34N4O2/c1-12(2)11-21-15-6-8-22(9-7-15)17(20)16(10-14(5)19)18(23)24-13(3)4/h10,12-13,15,21H,6-9,11,19-20H2,1-5H3 OHNDITWIBSZSMN-UHFFFAOYSA-N 156641 US9682966, 410::US20250346584, Compound 410 Kappa-type opioid receptor Homo sapiens 78.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156641 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156641&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263981 355041719 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572877 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)C(\N)=C(\C=C(\C)N)/C(=O)OC(C)C |r| InChI=1S/C21H38N4O3/c1-14(2)28-21(26)17(12-15(3)22)20(23)25-11-10-18(19(13-25)27-4)24-16-8-6-5-7-9-16/h12,14,16,18-19,24H,5-11,13,22-23H2,1-4H3 HBOXYLUJCBJXAV-UHFFFAOYSA-N 156642 US9682966, 411::US20250346584, Compound 411 Kappa-type opioid receptor Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156642 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156642&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263982 355041720 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572878 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NCC(C)(C)O)CC1 785904 US20250346584, Compound 412 Kappa-type opioid receptor Homo sapiens 476 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785904&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572879 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NCC(C)C)CC1 785905 US20250346584, Compound 413 Kappa-type opioid receptor Homo sapiens 22.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785905&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572880 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCC2)CC1 785906 US20250346584, Compound 414 Kappa-type opioid receptor Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785906 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785906&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572881 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCCC2)CC1 785907 US20250346584, Compound 415 Kappa-type opioid receptor Homo sapiens 3.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785907&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572882 CCC(CC)NC1CCN(c2nc3ccc(C)cc3cc2C(=N)/N=C(/C)O)CC1 785908 US20250346584, Compound 416 Kappa-type opioid receptor Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785908&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572883 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2(C)CCOCC2)CC1 785909 US20250346584, Compound 417 Kappa-type opioid receptor Homo sapiens 105 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785909&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572884 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(N[C@H]2CCC[C@@H]2O)CC1 785910 US20250346584, Compound 418 Kappa-type opioid receptor Homo sapiens 50.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785910&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572885 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCOC2)CC1 785911 US20250346584, Compound 419 Kappa-type opioid receptor Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785911&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572886 C/C(N)=C/C(=C(\N)N1CCC(NC2CCCCC2)CC1)c1noc(C)n1 785912 US20250346584, Compound 420 Kappa-type opioid receptor Homo sapiens 3.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785912&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572887 C[C@@H](O)CNC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 |r| InChI=1S/C21H27N5O2/c1-13-4-5-19-16(10-13)11-18(21-23-15(3)25-28-21)20(24-19)26-8-6-17(7-9-26)22-12-14(2)27/h4-5,10-11,14,17,22,27H,6-9,12H2,1-3H3 HGVDPSLWTCEZOP-UHFFFAOYSA-N 156653 US9682966, 421::US10118915, Compound 421::US20250346584, Compound 421 Kappa-type opioid receptor Homo sapiens 48.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156653 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156653&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263991 355041730 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572888 C[C@H](O)CNC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 |r| InChI=1S/C21H27N5O2/c1-13-4-5-19-16(10-13)11-18(21-23-15(3)25-28-21)20(24-19)26-8-6-17(7-9-26)22-12-14(2)27/h4-5,10-11,14,17,22,27H,6-9,12H2,1-3H3 HGVDPSLWTCEZOP-UHFFFAOYSA-N 156656 US9682966, 422::US10118915, Compound 422::US20250346584, Compound 422 Kappa-type opioid receptor Homo sapiens 106 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156656 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156656&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263992 355041731 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572889 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC[C@@H](C)O)CC1 785915 US20250346584, Compound 423 Kappa-type opioid receptor Homo sapiens 191 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785915&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572890 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC[C@H](C)O)CC1 785916 US20250346584, Compound 424 Kappa-type opioid receptor Homo sapiens 422 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785916&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572891 COC1CN(CCC1NC1CCCCC1)c1nc(CO)ccc1-c1nc(C)no1 InChI=1S/C21H31N5O3/c1-14-22-21(29-25-14)17-9-8-16(13-27)24-20(17)26-11-10-18(19(12-26)28-2)23-15-6-4-3-5-7-15/h8-9,15,18-19,23,27H,3-7,10-13H2,1-2H3 SXMHUEJQXDUMGX-UHFFFAOYSA-N 156666 US9682966, 425::US10118915, Compound 425::US20250346584, Compound 425 Kappa-type opioid receptor Homo sapiens 60.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156666 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156666&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118263996 355041734 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572892 CO[C@H]1CN(c2nc(C)ccc2C(=N)/C=C\C(C)=N)CC[C@H]1NC1CCCCC1 785918 US20250346584, Compound 426 Kappa-type opioid receptor Homo sapiens 1970 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785918 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785918&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572893 CO[C@@H]1CN(c2nc(C)ccc2C(=N)/C=C\C(C)=N)CC[C@@H]1NC1CCCCC1 785919 US20250346584, Compound 427 Kappa-type opioid receptor Homo sapiens 4600 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785919&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572894 CC(=N)/N=C(\O)c1ccc(CO)nc1N1CCC(NC2CCCCC2)CC1 785920 US20250346584, Compound 428 Kappa-type opioid receptor Homo sapiens 101 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785920&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572895 CO[C@H]1CN(c2nc(C)ccc2C(=N)/N=C(/C)O)CC[C@H]1NC1CCCCC1 785921 US20250346584, Compound 429 Kappa-type opioid receptor Homo sapiens 214 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785921&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572896 CO[C@@H]1CN(c2nc(C)ccc2C(=N)/N=C(/C)O)CC[C@@H]1NC1CCCCC1 785922 US20250346584, Compound 430 Kappa-type opioid receptor Homo sapiens 1000 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785922&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572897 C/C(N)=C/C(=C(\N)N1CCC(NCC(C)C)CC1)c1noc(C)n1 785923 US20250346584, Compound 431 Kappa-type opioid receptor Homo sapiens 22.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785923&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572898 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCOC2)CC1 785924 US20250346584, Compound 432 Kappa-type opioid receptor Homo sapiens 22.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785924&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572899 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NCC1CC1 InChI=1S/C22H27N5O/c1-14-3-6-20-17(11-14)12-19(22-24-15(2)26-28-22)21(25-20)27-9-7-18(8-10-27)23-13-16-4-5-16/h3,6,11-12,16,18,23H,4-5,7-10,13H2,1-2H3 IIVRURVOTPPDFG-UHFFFAOYSA-N 157256 US9682966, 433::US10118915, Compound 433::US20250346584, Compound 433 Kappa-type opioid receptor Homo sapiens 7.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157256 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157256&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264001 355041742 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572900 Cc1nc(no1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NCC1CC1 InChI=1S/C22H27N5O/c1-14-3-6-20-17(11-14)12-19(21-24-15(2)28-26-21)22(25-20)27-9-7-18(8-10-27)23-13-16-4-5-16/h3,6,11-12,16,18,23H,4-5,7-10,13H2,1-2H3 OMWUUHSARAHVJL-UHFFFAOYSA-N 157257 US9682966, 434::US10118915, Compound 434::US20250346584, Compound 434 Kappa-type opioid receptor Homo sapiens 43.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157257&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264005 355041743 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572901 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCC(F)(F)CC1 InChI=1S/C24H29F2N5O/c1-15-3-4-21-17(13-15)14-20(23-27-16(2)30-32-23)22(29-21)31-11-7-19(8-12-31)28-18-5-9-24(25,26)10-6-18/h3-4,13-14,18-19,28H,5-12H2,1-2H3 WYMDQZVGEZJPKC-UHFFFAOYSA-N 157258 US9682966, 435::US10118915, Compound 435::US20250346584, Compound 435 Kappa-type opioid receptor Homo sapiens 6.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157258 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157258&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264006 355041744 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572902 Cc1nc(no1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCC(F)(F)CC1 InChI=1S/C24H29F2N5O/c1-15-3-4-21-17(13-15)14-20(22-27-16(2)32-30-22)23(29-21)31-11-7-19(8-12-31)28-18-5-9-24(25,26)10-6-18/h3-4,13-14,18-19,28H,5-12H2,1-2H3 HHDALJLZXUBAPX-UHFFFAOYSA-N 157259 US9682966, 436::US10118915, Compound 436::US20250346584, Compound 436 Kappa-type opioid receptor Homo sapiens 26.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157259 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157259&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264007 355041745 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572903 Cc1nc(no1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCC[C@@H]1O |r| InChI=1S/C24H31N5O2/c1-15-7-8-20-17(13-15)14-19(23-25-16(2)31-28-23)24(27-20)29-11-9-18(10-12-29)26-21-5-3-4-6-22(21)30/h7-8,13-14,18,21-22,26,30H,3-6,9-12H2,1-2H3 JFQPGLDCWIQPJL-UHFFFAOYSA-N 157260 US9682966, 437::US10118915, Compound 437::US20250346584, Compound 437 Kappa-type opioid receptor Homo sapiens 17.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157260&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 129252308 355041746 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572904 CC(=N)/C=C\C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)CC1 785930 US20250346584, Compound 438 Kappa-type opioid receptor Homo sapiens 75.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785930 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785930&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572905 CO[C@H]1CN(c2nc3ccc(C)cc3cc2C(=N)/C=C\C(C)=N)CC[C@H]1NC1CCCCC1 785931 US20250346584, Compound 439 Kappa-type opioid receptor Homo sapiens 231 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785931 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785931&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572906 Cc1nc(no1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCC[C@@H]1O |r| InChI=1S/C23H29N5O2/c1-14-6-7-19-16(12-14)13-18(22-24-15(2)30-27-22)23(26-19)28-10-8-17(9-11-28)25-20-4-3-5-21(20)29/h6-7,12-13,17,20-21,25,29H,3-5,8-11H2,1-2H3 BAESDBWLLDOIMJ-UHFFFAOYSA-N 156650 US9682966, 440::US9682966, 418::US10118915, Compound 440::US20250346584, Compound 440 Kappa-type opioid receptor Homo sapiens 70.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=156650 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=156650&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264013 355041727 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572907 C/C(N)=C/C=C(\N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCOCC2)CC1 785933 US20250346584, Compound 441 Kappa-type opioid receptor Homo sapiens 392 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785933&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572908 C/C(N)=C/C=C(\N)c1cc2cc(C)ccc2nc1N1CCC(NCC(C)C)CC1 785934 US20250346584, Compound 442 Kappa-type opioid receptor Homo sapiens 324 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785934&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572909 C/C(N)=C/C=C(\N)c1cc2cc(C)ccc2nc1N1CCC(N[C@H]2CCCC[C@@H]2O)CC1 785935 US20250346584, Compound 443 Kappa-type opioid receptor Homo sapiens 33.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785935&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572910 CC(=N)/C=C\C(=N)c1cc2cc(C)ccc2nc1N1CCC(N[C@H]2CCCC2O)CC1 785936 US20250346584, Compound 444 Kappa-type opioid receptor Homo sapiens 634 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785936&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572911 CC(=N)/C=C\C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCC2)CC1 785937 US20250346584, Compound 445 Kappa-type opioid receptor Homo sapiens 55.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785937&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572912 C/C(O)=N/C(=N)c1c(N2CCC(N[C@H]3CCCC[C@@H]3O)CC2)nc2ccccc2c1C 785938 US20250346584, Compound 446 Kappa-type opioid receptor Homo sapiens 72.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785938&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572913 C/C(O)=N/C(=N)c1c(N2CCC(NC3CCOCC3)CC2)nc2ccccc2c1C 785939 US20250346584, Compound 447 Kappa-type opioid receptor Homo sapiens 1150 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785939&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572914 C/C(O)=N/C(=N)c1c(N2CCC(NCC(C)C)CC2)nc2ccccc2c1C 785940 US20250346584, Compound 448 Kappa-type opioid receptor Homo sapiens 226 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785940&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572915 CCC(CC)NC1CCN(c2nc3ccccc3c(C)c2C(=N)/N=C(/C)O)CC1 785941 US20250346584, Compound 449 Kappa-type opioid receptor Homo sapiens 129 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785941&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572916 Cc1nc(no1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCCC1O InChI=1S/C24H31N5O2/c1-15-7-8-20-17(13-15)14-19(23-25-16(2)31-28-23)24(27-20)29-11-9-18(10-12-29)26-21-5-3-4-6-22(21)30/h7-8,13-14,18,21-22,26,30H,3-6,9-12H2,1-2H3 JFQPGLDCWIQPJL-UHFFFAOYSA-N 157273 US9682966, 450::US10118915, Compound 450::US20250346584, Compound 450 Kappa-type opioid receptor Homo sapiens 11.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157273 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157273&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264021 355041758 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572917 CC(=N)/C=C\C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2O)CC1 785943 US20250346584, Compound 451 Kappa-type opioid receptor Homo sapiens 94.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785943&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572918 C/C(N)=C/C(=C(\N)N1CCC(N[C@H]2CCCC[C@@H]2O)CC1)c1noc(C)n1 785944 US20250346584, Compound 452 Kappa-type opioid receptor Homo sapiens 47.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785944&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572919 CCCC(C)NC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1noc(C)n1 InChI=1S/C23H31N5O/c1-5-6-16(3)24-19-9-11-28(12-10-19)23-20(22-25-17(4)29-27-22)14-18-13-15(2)7-8-21(18)26-23/h7-8,13-14,16,19,24H,5-6,9-12H2,1-4H3 ICNPETBZXKIIKU-UHFFFAOYSA-N 157276 US9682966, 453::US10118915, Compound 453::US20250346584, Compound 453 Kappa-type opioid receptor Homo sapiens 85.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157276&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264024 355041761 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572920 CCC(=N)/C=C\C(=N)c1cc2cc(C)ccc2nc1N1CCC(N[C@H]2CCCC[C@@H]2O)CC1 785946 US20250346584, Compound 454 Kappa-type opioid receptor Homo sapiens 783 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785946&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572921 CC(=N)/C=C\C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCCCC2)CC1 785947 US20250346584, Compound 455 Kappa-type opioid receptor Homo sapiens 1640 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785947&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572922 CO[C@H]1CN(/C(N)=C(/C=C(/C)N)c2nc(C3CC3)no2)CC[C@H]1NC1CCCCC1 785948 US20250346584, Compound 456 Kappa-type opioid receptor Homo sapiens 6.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785948&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572923 C/C(N)=C/C(=C(\N)N1CCC(NC2CCCCC2)CC1)c1nc(C2CC2)no1 785949 US20250346584, Compound 457 Kappa-type opioid receptor Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785949&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572924 CC(=N)/C=C\C(=N)c1cc2cc(C)ccc2nc1N1CCC(NC2CCOC2)CC1 785950 US20250346584, Compound 458 Kappa-type opioid receptor Homo sapiens 440 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785950&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572925 Cc1ccc2nc(N3CCC(NC4CCCCC4)CC3)c(C=N)cc2c1 785951 US20250346584, Compound 459 Kappa-type opioid receptor Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785951&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572926 Cc1ccc2nc(N3CCC(NC4CCCCC4)CC3)c(C=N)cc2c1 785952 US20250346584, Compound 460 Kappa-type opioid receptor Homo sapiens 141 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785952&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572927 Cc1noc(n1)-c1cc2cc(C)ccc2nc1N1CCC(C1)NC1CCCCC1 InChI=1S/C23H29N5O/c1-15-8-9-21-17(12-15)13-20(23-24-16(2)27-29-23)22(26-21)28-11-10-19(14-28)25-18-6-4-3-5-7-18/h8-9,12-13,18-19,25H,3-7,10-11,14H2,1-2H3 GFYBGXPLOMUQFG-UHFFFAOYSA-N 158187 US9682966, 461::US10118915, Compound 461::US20250346584, Compound 461 Kappa-type opioid receptor Homo sapiens 52.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158187&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264031 355041769 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572928 C\C(N)=C\C(=C(/N)N1CCC(C1)NC1CCCCC1)\c1nc(no1)C1CC1 InChI=1S/C20H32N6O/c1-13(21)11-17(20-24-19(25-27-20)14-7-8-14)18(22)26-10-9-16(12-26)23-15-5-3-2-4-6-15/h11,14-16,23H,2-10,12,21-22H2,1H3 DTSOWXRYBISVJD-UHFFFAOYSA-N 158188 US9682966, 462::US20250346584, Compound 462 Kappa-type opioid receptor Homo sapiens 320 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158188&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264032 355041770 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572929 COC1CN(c2nc3ccccc3cc2C(=N)/C=C\C=N)CCC1NC1CCCCC1 785955 US20250346584, Compound 463 Kappa-type opioid receptor Homo sapiens 54.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785955&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572930 N=C/C=C\C(=N)c1cc2ccccc2nc1N1CCC(NC2CCCCC2)CC1 785956 US20250346584, Compound 464 Kappa-type opioid receptor Homo sapiens 87.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785956&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572931 COC1CN(CCC1NC1CCCCC1)c1nc2ccccc2cc1-c1cnc(C)cn1 InChI=1S/C26H33N5O/c1-18-15-28-24(16-27-18)21-14-19-8-6-7-11-22(19)30-26(21)31-13-12-23(25(17-31)32-2)29-20-9-4-3-5-10-20/h6-8,11,14-16,20,23,25,29H,3-5,9-10,12-13,17H2,1-2H3 HPZASECEYZSWPC-UHFFFAOYSA-N 158191 US9682966, 465::US10118915, Compound 465::US20250346584, Compound 465 Kappa-type opioid receptor Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158191&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264035 355041773 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572932 Cc1cnc(cn1)-c1cc2ccccc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C25H31N5/c1-18-16-27-24(17-26-18)22-15-19-7-5-6-10-23(19)29-25(22)30-13-11-21(12-14-30)28-20-8-3-2-4-9-20/h5-7,10,15-17,20-21,28H,2-4,8-9,11-14H2,1H3 WCVRXDSDWBTXAT-UHFFFAOYSA-N 158351 US9682966, 466::US10118915, Compound 466::US20250346584, Compound 466 Kappa-type opioid receptor Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158351 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158351&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264037 355041774 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572933 Cc1nc(no1)-c1cc2cc(F)ccc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C23H28FN5O/c1-15-25-22(28-30-15)20-14-16-13-17(24)7-8-21(16)27-23(20)29-11-9-19(10-12-29)26-18-5-3-2-4-6-18/h7-8,13-14,18-19,26H,2-6,9-12H2,1H3 WUFIJBYXWJFILI-UHFFFAOYSA-N 158352 US9682966, 489::US9682966, 467::US10118915, Compound 467::US20250346584, Compound 467 Kappa-type opioid receptor Homo sapiens 431 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158352 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158352&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264041 355041775 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572934 Cc1nc(no1)-c1cc2cc(F)ccc2nc1N1CCC(CC1)NC1CCCC1 InChI=1S/C22H26FN5O/c1-14-24-21(27-29-14)19-13-15-12-16(23)6-7-20(15)26-22(19)28-10-8-18(9-11-28)25-17-4-2-3-5-17/h6-7,12-13,17-18,25H,2-5,8-11H2,1H3 UTUDMPQFQIQMPE-UHFFFAOYSA-N 158359 US9682966, 468::US10118915, Compound 468::US20250346584, Compound 468 Kappa-type opioid receptor Homo sapiens 175 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158359 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158359&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264039 355041776 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572935 Cc1nc(no1)-c1cc2cc(F)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C22H26FN5O2/c1-14-24-21(27-30-14)19-13-15-12-16(23)2-3-20(15)26-22(19)28-8-4-17(5-9-28)25-18-6-10-29-11-7-18/h2-3,12-13,17-18,25H,4-11H2,1H3 QJAIQKFLEVYDAM-UHFFFAOYSA-N 158363 US9682966, 469::US10118915, Compound 469::US20250346584, Compound 469 Kappa-type opioid receptor Homo sapiens 440 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158363&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264044 355041777 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572936 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccccc2cc1-c1cnc(C)cn1 |r| InChI=1S/C26H33N5O/c1-18-15-28-24(16-27-18)21-14-19-8-6-7-11-22(19)30-26(21)31-13-12-23(25(17-31)32-2)29-20-9-4-3-5-10-20/h6-8,11,14-16,20,23,25,29H,3-5,9-10,12-13,17H2,1-2H3 HPZASECEYZSWPC-UHFFFAOYSA-N 158364 US9682966, 470::US10118915, Compound 470::US20250346584, Compound 470 Kappa-type opioid receptor Homo sapiens 40.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158364&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264046 355041778 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572937 CO[C@@H]1CN(CC[C@@H]1NC1CCCCC1)c1nc2ccccc2cc1-c1cnc(C)cn1 |r| InChI=1S/C26H33N5O/c1-18-15-28-24(16-27-18)21-14-19-8-6-7-11-22(19)30-26(21)31-13-12-23(25(17-31)32-2)29-20-9-4-3-5-10-20/h6-8,11,14-16,20,23,25,29H,3-5,9-10,12-13,17H2,1-2H3 HPZASECEYZSWPC-UHFFFAOYSA-N 158365 US9682966, 471::US10118915, Compound 471::US20250346584, Compound 471 Kappa-type opioid receptor Homo sapiens 170 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158365 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158365&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264051 355041779 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572938 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1ncc(C)cc1-c1cnc(C)cn1 |r| InChI=1S/C23H33N5O/c1-16-11-19(21-14-24-17(2)13-25-21)23(26-12-16)28-10-9-20(22(15-28)29-3)27-18-7-5-4-6-8-18/h11-14,18,20,22,27H,4-10,15H2,1-3H3 CGUPIHDSSMRRPU-UHFFFAOYSA-N 158374 US9682966, 472::US10118915, Compound 472::US20250346584, Compound 472 Kappa-type opioid receptor Homo sapiens 105 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158374&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264048 355041780 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572939 Cc1cnc(N2CCC(CC2)NC2CCOCC2)c(c1)-c1cnc(C)cn1 InChI=1S/C21H29N5O/c1-15-11-19(20-14-22-16(2)13-23-20)21(24-12-15)26-7-3-17(4-8-26)25-18-5-9-27-10-6-18/h11-14,17-18,25H,3-10H2,1-2H3 MPUDPJOQEVNQBZ-UHFFFAOYSA-N 158375 US9682966, 473::US10118915, Compound 473::US20250346584, Compound 473 Kappa-type opioid receptor Homo sapiens 3210 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158375&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264055 355041781 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572940 Cc1nc(no1)-c1cc2cc(F)ccc2nc1N1CCC(CC1)N[C@H]1CCC[C@@H]1O |r| InChI=1S/C22H26FN5O2/c1-13-24-21(27-30-13)17-12-14-11-15(23)5-6-18(14)26-22(17)28-9-7-16(8-10-28)25-19-3-2-4-20(19)29/h5-6,11-12,16,19-20,25,29H,2-4,7-10H2,1H3 WESNDVQYTAORBR-UHFFFAOYSA-N 158376 US9682966, 474::US20250346584, Compound 474 Kappa-type opioid receptor Homo sapiens 1900 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158376 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158376&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264047 355041782 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572941 Cc1nc(no1)-c1cc2cc(F)ccc2nc1N1CCC(CC1)N[C@@H]1CCCC[C@H]1O |r| InChI=1S/C23H28FN5O2/c1-14-25-22(28-31-14)18-13-15-12-16(24)6-7-19(15)27-23(18)29-10-8-17(9-11-29)26-20-4-2-3-5-21(20)30/h6-7,12-13,17,20-21,26,30H,2-5,8-11H2,1H3 OWTCMDHERHLLAX-UHFFFAOYSA-N 158382 US9682966, 475::US10118915, Compound 475::US20250346584, Compound 475 Kappa-type opioid receptor Homo sapiens 101 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158382&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264050 355041783 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572942 Cc1noc(n1)-c1cc2cc(F)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C22H26FN5O2/c1-14-24-22(30-27-14)19-13-15-12-16(23)2-3-20(15)26-21(19)28-8-4-17(5-9-28)25-18-6-10-29-11-7-18/h2-3,12-13,17-18,25H,4-11H2,1H3 GFRIUEKSXRCAHA-UHFFFAOYSA-N 158383 US9682966, 476::US10118915, Compound 476::US20250346584, Compound 476 Kappa-type opioid receptor Homo sapiens 430 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158383 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158383&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264054 355041784 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572943 Cc1noc(n1)-c1cc2c(F)cccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C22H26FN5O2/c1-14-24-22(30-27-14)18-13-17-19(23)3-2-4-20(17)26-21(18)28-9-5-15(6-10-28)25-16-7-11-29-12-8-16/h2-4,13,15-16,25H,5-12H2,1H3 POVYBDZESGTOMQ-UHFFFAOYSA-N 158384 US9682966, 477::US10118915, Compound 477::US20250346584, Compound 477 Kappa-type opioid receptor Homo sapiens 42.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158384 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158384&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264049 355041785 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572944 CC(=O)c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C22H29N3O2/c1-15-3-4-21-17(13-15)14-20(16(2)26)22(24-21)25-9-5-18(6-10-25)23-19-7-11-27-12-8-19/h3-4,13-14,18-19,23H,5-12H2,1-2H3 SSJVTJGQYSBAPR-UHFFFAOYSA-N 158391 US9682966, 478::US10118915, Compound 478::US20250346584, Compound 478 Kappa-type opioid receptor Homo sapiens 900 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158391&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264052 355041786 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572945 CC(=O)c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C23H31N3O/c1-16-8-9-22-18(14-16)15-21(17(2)27)23(25-22)26-12-10-20(11-13-26)24-19-6-4-3-5-7-19/h8-9,14-15,19-20,24H,3-7,10-13H2,1-2H3 YXWFHGPPUVPIAE-UHFFFAOYSA-N 158392 US9682966, 479::US10118915, Compound 479::US20250346584, Compound 479 Kappa-type opioid receptor Homo sapiens 211 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158392&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264058 355041787 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572946 Cc1nc(no1)-c1cc2ccc(F)cc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C23H28FN5O/c1-15-25-22(28-30-15)20-13-16-7-8-17(24)14-21(16)27-23(20)29-11-9-19(10-12-29)26-18-5-3-2-4-6-18/h7-8,13-14,18-19,26H,2-6,9-12H2,1H3 IGWIIEMXLDBNTI-UHFFFAOYSA-N 158393 US9682966, 480::US10118915, Compound 480::US20250346584, Compound 480 Kappa-type opioid receptor Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158393&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264057 355041788 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572947 Cc1nc(no1)-c1cc2ccc(F)cc2nc1N1CCC(CC1)NC1CCCC1 InChI=1S/C22H26FN5O/c1-14-24-21(27-29-14)19-12-15-6-7-16(23)13-20(15)26-22(19)28-10-8-18(9-11-28)25-17-4-2-3-5-17/h6-7,12-13,17-18,25H,2-5,8-11H2,1H3 AFVZPBXGBZUBMQ-UHFFFAOYSA-N 158394 US9682966, 481::US10118915, Compound 481::US20250346584, Compound 481 Kappa-type opioid receptor Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158394 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158394&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264053 355041789 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572948 Cc1nc(no1)-c1cc2ccc(F)cc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C22H26FN5O2/c1-14-24-21(27-30-14)19-12-15-2-3-16(23)13-20(15)26-22(19)28-8-4-17(5-9-28)25-18-6-10-29-11-7-18/h2-3,12-13,17-18,25H,4-11H2,1H3 VPKAAJOMMHEREM-UHFFFAOYSA-N 158396 US9682966, 482::US10118915, Compound 486::US20250346584, Compound 482 Kappa-type opioid receptor Homo sapiens 75.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158396 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158396&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264056 355041790 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572949 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccc(C)cc2cc1C(C)=O |r| InChI=1S/C24H33N3O2/c1-16-9-10-21-18(13-16)14-20(17(2)28)24(26-21)27-12-11-22(23(15-27)29-3)25-19-7-5-4-6-8-19/h9-10,13-14,19,22-23,25H,4-8,11-12,15H2,1-3H3 JAIGQXYBWGGMGS-UHFFFAOYSA-N 158407 US9682966, 483::US10118915, Compound 483::US20250346584, Compound 483 Kappa-type opioid receptor Homo sapiens 315 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158407 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158407&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264059 355041791 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572950 CO[C@@H]1CN(CC[C@@H]1NC1CCCCC1)c1nc2ccc(C)cc2cc1C(C)=O |r| InChI=1S/C24H33N3O2/c1-16-9-10-21-18(13-16)14-20(17(2)28)24(26-21)27-12-11-22(23(15-27)29-3)25-19-7-5-4-6-8-19/h9-10,13-14,19,22-23,25H,4-8,11-12,15H2,1-3H3 JAIGQXYBWGGMGS-UHFFFAOYSA-N 158688 US9682966, 484::US10118915, Compound 484::US20250346584, Compound 484 Kappa-type opioid receptor Homo sapiens 347 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158688 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158688&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264060 355041792 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572951 Cc1nc(-c2cc3ccc(F)cc3nc2N2CCC(N[C@H]3CCCC[C@@H]3O)CC2)no1 785977 US20250346584, Compound 485 Kappa-type opioid receptor Homo sapiens 673 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785977&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572952 Cc1nc(-c2cc3ccc(F)cc3nc2N2CCC(N[C@H]3CCCOC3)CC2)no1 785978 US20250346584, Compound 486 Kappa-type opioid receptor Homo sapiens 1070 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785978&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572953 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2c(C)c(F)ccc2cc1-c1nc(C)no1 |r| InChI=1S/C25H32FN5O2/c1-15-20(26)10-9-17-13-19(25-27-16(2)30-33-25)24(29-23(15)17)31-12-11-21(22(14-31)32-3)28-18-7-5-4-6-8-18/h9-10,13,18,21-22,28H,4-8,11-12,14H2,1-3H3 WGAAINOKSFJJSS-UHFFFAOYSA-N 158780 US9682966, 487::US10118915, Compound 487::US20250346584, Compound 487 Kappa-type opioid receptor Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158780&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264062 355041795 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572954 Cc1ccc(o1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C26H33N3O/c1-18-8-10-24-20(16-18)17-23(25-11-9-19(2)30-25)26(28-24)29-14-12-22(13-15-29)27-21-6-4-3-5-7-21/h8-11,16-17,21-22,27H,3-7,12-15H2,1-2H3 AQUQZVPTBRTWFQ-UHFFFAOYSA-N 158840 US9682966, 488::US10118915, Compound 488::US20250346584, Compound 488 Kappa-type opioid receptor Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158840 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158840&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264063 355041796 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572955 C/C(O)=N/C(=N)c1cc2cc(F)ccc2nc1N1CCC(NC2CCCCCC2)CC1 785981 US20250346584, Compound 489 Kappa-type opioid receptor Homo sapiens 616 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785981&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572956 CCC(CC)NC1CCN(c2nc3ccc(F)cc3cc2C(=N)/N=C(/C)O)CC1 785982 US20250346584, Compound 490 Kappa-type opioid receptor Homo sapiens 248 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785982&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572957 Cc1noc(n1)-c1cc2ccc(F)c(C)c2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C24H30FN5O/c1-15-21(25)9-8-17-14-20(24-26-16(2)29-31-24)23(28-22(15)17)30-12-10-19(11-13-30)27-18-6-4-3-5-7-18/h8-9,14,18-19,27H,3-7,10-13H2,1-2H3 KEYNESCRUYNXSK-UHFFFAOYSA-N 158869 US9682966, 491::US10118915, Compound 491::US20250346584, Compound 491 Kappa-type opioid receptor Homo sapiens 33.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158869&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264067 355041798 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572958 CO[C@@H]1CN(CC[C@@H]1NC1CCCCC1)c1nc2c(C)c(F)ccc2cc1-c1nc(C)no1 |r| InChI=1S/C25H32FN5O2/c1-15-20(26)10-9-17-13-19(25-27-16(2)30-33-25)24(29-23(15)17)31-12-11-21(22(14-31)32-3)28-18-7-5-4-6-8-18/h9-10,13,18,21-22,28H,4-8,11-12,14H2,1-3H3 WGAAINOKSFJJSS-UHFFFAOYSA-N 158872 US9682966, 492::US10118915, Compound 492::US20250346584, Compound 492 Kappa-type opioid receptor Homo sapiens 74.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158872&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264068 355041799 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572959 Cc1noc(n1)-c1cc2ccc(F)c(C)c2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C23H28FN5O2/c1-14-20(24)4-3-16-13-19(23-25-15(2)28-31-23)22(27-21(14)16)29-9-5-17(6-10-29)26-18-7-11-30-12-8-18/h3-4,13,17-18,26H,5-12H2,1-2H3 UMLJSTZQCPYSHV-UHFFFAOYSA-N 158877 US9682966, 493::US10118915, Compound 493::US20250346584, Compound 493 Kappa-type opioid receptor Homo sapiens 132 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158877&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264069 355041800 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572960 CC(C)CNC1CCN(CC1)c1nc2c(C)c(F)ccc2cc1-c1nc(C)no1 InChI=1S/C22H28FN5O/c1-13(2)12-24-17-7-9-28(10-8-17)21-18(22-25-15(4)27-29-22)11-16-5-6-19(23)14(3)20(16)26-21/h5-6,11,13,17,24H,7-10,12H2,1-4H3 GAJFMKCBRGVEFU-UHFFFAOYSA-N 158882 US9682966, 494::US10118915, Compound 494::US20250346584, Compound 494 Kappa-type opioid receptor Homo sapiens 64.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158882&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264070 355041801 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572961 Cc1nc(no1)-c1cc2cc(C)c(F)cc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C24H30FN5O/c1-15-12-17-13-20(23-26-16(2)31-29-23)24(28-22(17)14-21(15)25)30-10-8-19(9-11-30)27-18-6-4-3-5-7-18/h12-14,18-19,27H,3-11H2,1-2H3 ICZFEYQFWCKZCN-UHFFFAOYSA-N 158905 US9682966, 495::US10118915, Compound 495::US20250346584, Compound 495 Kappa-type opioid receptor Homo sapiens 13.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158905&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264071 355041802 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572962 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2cc(F)c(C)cc2cc1-c1nc(C)no1 |r| InChI=1S/C25H32FN5O2/c1-15-11-17-12-19(25-27-16(2)30-33-25)24(29-22(17)13-20(15)26)31-10-9-21(23(14-31)32-3)28-18-7-5-4-6-8-18/h11-13,18,21,23,28H,4-10,14H2,1-3H3 GUOLAAHMVWSILT-UHFFFAOYSA-N 158926 US9682966, 496::US10118915, Compound 496::US20250346584, Compound 496 Kappa-type opioid receptor Homo sapiens 54.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158926&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264072 355041803 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572963 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccc(C)cc2cc1-c1ccc(C)o1 |r| InChI=1S/C27H35N3O2/c1-18-9-11-23-20(15-18)16-22(25-12-10-19(2)32-25)27(29-23)30-14-13-24(26(17-30)31-3)28-21-7-5-4-6-8-21/h9-12,15-16,21,24,26,28H,4-8,13-14,17H2,1-3H3 APWOOIIFGHTQQC-UHFFFAOYSA-N 158933 US9682966, 497::US10118915, Compound 497::US20250346584, Compound 497 Kappa-type opioid receptor Homo sapiens 48.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158933&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264073 355041804 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572964 CC(C)CNC1CCN(CC1)c1nc2cc(F)c(C)cc2cc1-c1nc(C)no1 InChI=1S/C22H28FN5O/c1-13(2)12-24-17-5-7-28(8-6-17)21-18(22-25-15(4)27-29-22)10-16-9-14(3)19(23)11-20(16)26-21/h9-11,13,17,24H,5-8,12H2,1-4H3 NGMZHGVVULZQKV-UHFFFAOYSA-N 158937 US9682966, 498::US10118915, Compound 498::US20250346584, Compound 498 Kappa-type opioid receptor Homo sapiens 33.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158937&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264074 355041805 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572965 Cc1ccc(o1)-c1cc(C)cnc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C22H31N3O/c1-16-14-20(21-9-8-17(2)26-21)22(23-15-16)25-12-10-19(11-13-25)24-18-6-4-3-5-7-18/h8-9,14-15,18-19,24H,3-7,10-13H2,1-2H3 KRIOODLHFUWQCF-UHFFFAOYSA-N 158956 US9682966, 499::US10118915, Compound 499::US20250346584, Compound 499 Kappa-type opioid receptor Homo sapiens 116 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158956&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264075 355041806 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572966 CO[C@H]1CN(CC[C@H]1NC1CCOCC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 |r| InChI=1S/C24H31N5O3/c1-15-4-5-20-17(12-15)13-19(24-25-16(2)28-32-24)23(27-20)29-9-6-21(22(14-29)30-3)26-18-7-10-31-11-8-18/h4-5,12-13,18,21-22,26H,6-11,14H2,1-3H3 QPTLSLJLZSPXTO-UHFFFAOYSA-N 158957 US9682966, 500::US10118915, Compound 500::US20250346584, Compound 500 Kappa-type opioid receptor Homo sapiens 423 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158957&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264076 355041807 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572967 Cc1ccc(o1)-c1cc2cc(C)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C25H31N3O2/c1-17-3-5-23-19(15-17)16-22(24-6-4-18(2)30-24)25(27-23)28-11-7-20(8-12-28)26-21-9-13-29-14-10-21/h3-6,15-16,20-21,26H,7-14H2,1-2H3 ITUGCRMNTBGGDI-UHFFFAOYSA-N 158958 US9682966, 501::US10118915, Compound 501::US20250346584, Compound 501 Kappa-type opioid receptor Homo sapiens 331 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158958&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264082 355041808 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572968 CO[C@H]1CN(C(=N)/C(=C\C(C)=N)c2nc(C)no2)CC[C@H]1NC1CCOCC1 785994 US20250346584, Compound 502 Kappa-type opioid receptor Homo sapiens 3109 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785994&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572969 Cc1nc(no1)-c1cc2ccc(F)c(C)c2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C24H30FN5O/c1-15-21(25)9-8-17-14-20(23-26-16(2)31-29-23)24(28-22(15)17)30-12-10-19(11-13-30)27-18-6-4-3-5-7-18/h8-9,14,18-19,27H,3-7,10-13H2,1-2H3 LCDIDUSIJVTISN-UHFFFAOYSA-N 158961 US9682966, 503::US10118915, Compound 503::US20250346584, Compound 503 Kappa-type opioid receptor Homo sapiens 74.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158961&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264077 355041810 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572970 Cc1nc(no1)-c1cc2ccc(F)c(C)c2nc1N1CCC(CC1)NC1CCCC1 InChI=1S/C23H28FN5O/c1-14-20(24)8-7-16-13-19(22-25-15(2)30-28-22)23(27-21(14)16)29-11-9-18(10-12-29)26-17-5-3-4-6-17/h7-8,13,17-18,26H,3-6,9-12H2,1-2H3 WSIHQHPNOQDJJM-UHFFFAOYSA-N 158965 US9682966, 504::US10118915, Compound 504::US20250346584, Compound 504 Kappa-type opioid receptor Homo sapiens 45.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158965&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264078 355041811 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572971 CC(C)CNC1CCN(CC1)c1nc2c(C)c(F)ccc2cc1-c1noc(C)n1 InChI=1S/C22H28FN5O/c1-13(2)12-24-17-7-9-28(10-8-17)22-18(21-25-15(4)29-27-21)11-16-5-6-19(23)14(3)20(16)26-22/h5-6,11,13,17,24H,7-10,12H2,1-4H3 QOOVJGPITYNAAA-UHFFFAOYSA-N 158968 US9682966, 505::US10118915, Compound 505::US20250346584, Compound 505 Kappa-type opioid receptor Homo sapiens 126 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158968&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264079 355041812 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572972 Cc1nc(-c2cc3cc(C)c(F)cc3nc2N2CCC(N[C@H]3CCCC[C@@H]3O)CC2)no1 785998 US20250346584, Compound 506 Kappa-type opioid receptor Homo sapiens 48.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785998&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572973 Cc1nc(no1)-c1cc2cc(C)c(F)cc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C23H28FN5O2/c1-14-11-16-12-19(22-25-15(2)31-28-22)23(27-21(16)13-20(14)24)29-7-3-17(4-8-29)26-18-5-9-30-10-6-18/h11-13,17-18,26H,3-10H2,1-2H3 WGOUYBLOPQTANG-UHFFFAOYSA-N 158976 US9682966, 507::US10118915, Compound 507::US20250346584, Compound 507 Kappa-type opioid receptor Homo sapiens 43.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158976&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264090 355041814 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572974 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2cc(F)ccc2cc1-c1nc(C)no1 |r| InChI=1S/C24H30FN5O2/c1-15-26-24(32-29-15)19-12-16-8-9-17(25)13-21(16)28-23(19)30-11-10-20(22(14-30)31-2)27-18-6-4-3-5-7-18/h8-9,12-13,18,20,22,27H,3-7,10-11,14H2,1-2H3 IWFHJBIRTRKTBZ-UHFFFAOYSA-N 158978 US9682966, 508::US10118915, Compound 508::US20250346584, Compound 508 Kappa-type opioid receptor Homo sapiens 5.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158978&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264083 355041815 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572975 CC(C)CNC1CCN(CC1)C(\N)=C(\C=C(\C)N)/c1nc(no1)C1CC1 InChI=1S/C19H32N6O/c1-12(2)11-22-15-6-8-25(9-7-15)17(21)16(10-13(3)20)19-23-18(24-26-19)14-4-5-14/h10,12,14-15,22H,4-9,11,20-21H2,1-3H3 FOGFRNMZTJNDGE-UHFFFAOYSA-N 158979 US9682966, 509::US20250346584, Compound 509 Kappa-type opioid receptor Homo sapiens 30.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158979&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264115 355041816 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572976 Cc1nc(no1)-c1cc2ccc(F)c(C)c2nc1N1CCC(CC1)N[C@H]1CCCC[C@@H]1O |r| InChI=1S/C24H30FN5O2/c1-14-19(25)8-7-16-13-18(23-26-15(2)32-29-23)24(28-22(14)16)30-11-9-17(10-12-30)27-20-5-3-4-6-21(20)31/h7-8,13,17,20-21,27,31H,3-6,9-12H2,1-2H3 OFYLJQIBRWYMOE-UHFFFAOYSA-N 158980 US9682966, 510::US20250346584, Compound 510 Kappa-type opioid receptor Homo sapiens 115 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158980&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264085 355041817 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572977 Cc1nc(no1)-c1cc2ccc(F)c(C)c2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C23H28FN5O2/c1-14-20(24)4-3-16-13-19(22-25-15(2)31-28-22)23(27-21(14)16)29-9-5-17(6-10-29)26-18-7-11-30-12-8-18/h3-4,13,17-18,26H,5-12H2,1-2H3 DAECPHSEQRNJED-UHFFFAOYSA-N 158986 US9682966, 511::US10118915, Compound 511::US20250346584, Compound 511 Kappa-type opioid receptor Homo sapiens 227 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158986&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264086 355041818 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572978 Cc1nc(no1)-c1cc2cc(C)c(F)cc2nc1N1CCC(CC1)NC1CCCC1 InChI=1S/C23H28FN5O/c1-14-11-16-12-19(22-25-15(2)30-28-22)23(27-21(16)13-20(14)24)29-9-7-18(8-10-29)26-17-5-3-4-6-17/h11-13,17-18,26H,3-10H2,1-2H3 HZVJHDPUGIBRDM-UHFFFAOYSA-N 158988 US9682966, 512::US10118915, Compound 512::US20250346584, Compound 512 Kappa-type opioid receptor Homo sapiens 12.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158988&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264084 355041819 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572979 CC(C)CNC1CCN(CC1)c1nc2cc(F)c(C)cc2cc1-c1noc(C)n1 InChI=1S/C22H28FN5O/c1-13(2)12-24-17-5-7-28(8-6-17)22-18(21-25-15(4)29-27-21)10-16-9-14(3)19(23)11-20(16)26-22/h9-11,13,17,24H,5-8,12H2,1-4H3 HYVDLRXFJWGWEG-UHFFFAOYSA-N 158992 US9682966, 513::US10118915, Compound 513::US20250346584, Compound 513 Kappa-type opioid receptor Homo sapiens 27.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158992&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264087 355041820 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572980 CO[C@@H]1CN(CC[C@@H]1NC1CCCCC1)c1nc2cc(F)ccc2cc1-c1nc(C)no1 |r| InChI=1S/C24H30FN5O2/c1-15-26-24(32-29-15)19-12-16-8-9-17(25)13-21(16)28-23(19)30-11-10-20(22(14-30)31-2)27-18-6-4-3-5-7-18/h8-9,12-13,18,20,22,27H,3-7,10-11,14H2,1-2H3 IWFHJBIRTRKTBZ-UHFFFAOYSA-N 158995 US9682966, 514::US10118915, Compound 514::US20250346584, Compound 514 Kappa-type opioid receptor Homo sapiens 55.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158995&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264088 355041821 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572981 Cc1noc(n1)-c1cc2ccc(F)cc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C23H28FN5O/c1-15-25-23(30-28-15)20-13-16-7-8-17(24)14-21(16)27-22(20)29-11-9-19(10-12-29)26-18-5-3-2-4-6-18/h7-8,13-14,18-19,26H,2-6,9-12H2,1H3 MKKWGFBFPWOLQH-UHFFFAOYSA-N 158998 US9682966, 515::US10118915, Compound 515::US20250346584, Compound 515 Kappa-type opioid receptor Homo sapiens 7.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158998&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264089 355041822 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572982 Cc1ccc2nc(N3CCC(CC3)N[C@H]3CCCC[C@@H]3O)c(cc2c1)-c1ccncn1 |r| InChI=1S/C25H31N5O/c1-17-6-7-21-18(14-17)15-20(22-8-11-26-16-27-22)25(29-21)30-12-9-19(10-13-30)28-23-4-2-3-5-24(23)31/h6-8,11,14-16,19,23-24,28,31H,2-5,9-10,12-13H2,1H3 TZVRKACMDVUXDJ-UHFFFAOYSA-N 159000 US9682966, 516::US20250346584, Compound 516 Kappa-type opioid receptor Homo sapiens 564 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159000&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264091 355041823 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572983 Cc1cnc(N2CCC(CC2)NC2CCCCC2)c(c1)-c1ccncn1 InChI=1S/C21H29N5/c1-16-13-19(20-7-10-22-15-24-20)21(23-14-16)26-11-8-18(9-12-26)25-17-5-3-2-4-6-17/h7,10,13-15,17-18,25H,2-6,8-9,11-12H2,1H3 HAZJLOHKEUOOEM-UHFFFAOYSA-N 159002 US9682966, 517::US10118915, Compound 517::US20250346584, Compound 517 Kappa-type opioid receptor Homo sapiens 1142 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159002&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264117 355041824 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572984 Cc1noc(n1)-c1nc2cc(C)ccc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C22H28N6O2/c1-14-3-4-18-19(13-14)25-20(22-23-15(2)27-30-22)21(26-18)28-9-5-16(6-10-28)24-17-7-11-29-12-8-17/h3-4,13,16-17,24H,5-12H2,1-2H3 KECBPTQUOUCNOL-UHFFFAOYSA-N 159004 US9682966, 518::US10118915, Compound 518::US20250346584, Compound 518 Kappa-type opioid receptor Homo sapiens 410 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159004&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264118 355041825 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572985 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2ccc(C)cc2nc1-c1nc(C)no1 |r| InChI=1S/C24H32N6O2/c1-15-9-10-18-20(13-15)27-22(24-25-16(2)29-32-24)23(28-18)30-12-11-19(21(14-30)31-3)26-17-7-5-4-6-8-17/h9-10,13,17,19,21,26H,4-8,11-12,14H2,1-3H3 YEVGTVOCFFWNAW-UHFFFAOYSA-N 159006 US9682966, 519::US10118915, Compound 519::US20250346584, Compound 519 Kappa-type opioid receptor Homo sapiens 95.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159006&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264093 355041826 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572986 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2cccc(F)c2cc1-c1nc(C)no1 |r| InChI=1S/C24H30FN5O2/c1-15-26-24(32-29-15)18-13-17-19(25)9-6-10-20(17)28-23(18)30-12-11-21(22(14-30)31-2)27-16-7-4-3-5-8-16/h6,9-10,13,16,21-22,27H,3-5,7-8,11-12,14H2,1-2H3 AQAGMWIEZLEMBH-UHFFFAOYSA-N 159015 US9682966, 520::US10118915, Compound 520::US20250346584, Compound 520 Kappa-type opioid receptor Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159015&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264104 355041827 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572987 CO[C@H]1CN(CC[C@H]1NC1CCC(F)(F)CC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 |r| InChI=1S/C25H31F2N5O2/c1-15-4-5-20-17(12-15)13-19(24-28-16(2)31-34-24)23(30-20)32-11-8-21(22(14-32)33-3)29-18-6-9-25(26,27)10-7-18/h4-5,12-13,18,21-22,29H,6-11,14H2,1-3H3 SCCOOPCJPBGZQP-UHFFFAOYSA-N 159017 US9682966, 521::US10118915, Compound 521::US20250346584, Compound 521 Kappa-type opioid receptor Homo sapiens 278 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159017&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264092 355041828 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572988 CO[C@@H]1CN(CC[C@@H]1NC1CCOCC1)c1nc2ccc(C)cc2cc1-c1nc(C)no1 |r| InChI=1S/C24H31N5O3/c1-15-4-5-20-17(12-15)13-19(24-25-16(2)28-32-24)23(27-20)29-9-6-21(22(14-29)30-3)26-18-7-10-31-11-8-18/h4-5,12-13,18,21-22,26H,6-11,14H2,1-3H3 QPTLSLJLZSPXTO-UHFFFAOYSA-N 159019 US9682966, 522::US10118915, Compound 522::US20250346584, Compound 522 Kappa-type opioid receptor Homo sapiens 67.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159019&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264099 355041829 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572989 CCc1ccc2nc(N3CCC(CC3)N[C@H](C)C(C)C)c(cc2c1)-c1nc(C)no1 |r| InChI=1S/C24H33N5O/c1-6-18-7-8-22-19(13-18)14-21(24-26-17(5)28-30-24)23(27-22)29-11-9-20(10-12-29)25-16(4)15(2)3/h7-8,13-16,20,25H,6,9-12H2,1-5H3 NCMLJUYBNDZNQL-UHFFFAOYSA-N 159020 US9682966, 523::US10118915, Compound 523::US20250346584, Compound 523 Kappa-type opioid receptor Homo sapiens 7.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159020&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264094 355041830 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572990 C/C(O)=N/C(=N)c1cc2cc(C)ccc2nc1N1CCC(N[C@H](C)C(C)C)CC1 786016 US20250346584, Compound 524 Kappa-type opioid receptor Homo sapiens 57.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786016&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572991 CC[C@@H](C)NC1CCN(CC1)c1nc2ccc(CC)cc2cc1-c1nc(C)no1 |r| InChI=1S/C23H31N5O/c1-5-15(3)24-19-9-11-28(12-10-19)22-20(23-25-16(4)27-29-23)14-18-13-17(6-2)7-8-21(18)26-22/h7-8,13-15,19,24H,5-6,9-12H2,1-4H3 ONYHAOCQEWBMFY-UHFFFAOYSA-N 159030 US9682966, 525::US10118915, Compound 525::US20250346584, Compound 525 Kappa-type opioid receptor Homo sapiens 17.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159030&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264102 355041832 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572992 CC(C)CNC1CCN(CC1)c1nc2cccc(F)c2cc1-c1nc(C)no1 InChI=1S/C21H26FN5O/c1-13(2)12-23-15-7-9-27(10-8-15)20-17(21-24-14(3)26-28-21)11-16-18(22)5-4-6-19(16)25-20/h4-6,11,13,15,23H,7-10,12H2,1-3H3 RSQPVXFLPFAEHK-UHFFFAOYSA-N 159032 US9682966, 526::US10118915, Compound 526::US20250346584, Compound 526 Kappa-type opioid receptor Homo sapiens 49.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159032&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264103 355041833 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572993 CC(C)CNC1CCN(CC1)c1nc2cc(F)ccc2cc1-c1nc(C)no1 InChI=1S/C21H26FN5O/c1-13(2)12-23-17-6-8-27(9-7-17)20-18(21-24-14(3)26-28-21)10-15-4-5-16(22)11-19(15)25-20/h4-5,10-11,13,17,23H,6-9,12H2,1-3H3 PAPHKYDHERJIMA-UHFFFAOYSA-N 159035 US9682966, 527::US10118915, Compound 527::US20250346584, Compound 527 Kappa-type opioid receptor Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159035&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264095 355041834 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572994 Cc1noc(n1)-c1cc2ccc(F)cc2nc1N1CCC(CC1)NC1CCOCC1 InChI=1S/C22H26FN5O2/c1-14-24-22(30-27-14)19-12-15-2-3-16(23)13-20(15)26-21(19)28-8-4-17(5-9-28)25-18-6-10-29-11-7-18/h2-3,12-13,17-18,25H,4-11H2,1H3 PMLZZMRWIUBQHB-UHFFFAOYSA-N 159037 US9682966, 528::US10118915, Compound 528::US20250346584, Compound 528 Kappa-type opioid receptor Homo sapiens 23.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159037&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264096 355041835 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572995 CO[C@H]1CN(CC[C@H]1NCC(C)C)c1nc2ccc(C)cc2cc1-c1nc(C)no1 |r| InChI=1S/C23H31N5O2/c1-14(2)12-24-20-8-9-28(13-21(20)29-5)22-18(23-25-16(4)27-30-23)11-17-10-15(3)6-7-19(17)26-22/h6-7,10-11,14,20-21,24H,8-9,12-13H2,1-5H3 SXXOZDYJQYJAAX-UHFFFAOYSA-N 159045 US9682966, 529::US10118915, Compound 529::US20250346584, Compound 529 Kappa-type opioid receptor Homo sapiens 369 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159045&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264106 355041836 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572996 CO[C@H]1CN(CC[C@H]1NCC(C)C)c1nc2ccc(F)cc2cc1-c1nc(C)no1 |r| InChI=1S/C22H28FN5O2/c1-13(2)11-24-19-7-8-28(12-20(19)29-4)21-17(22-25-14(3)27-30-22)10-15-9-16(23)5-6-18(15)26-21/h5-6,9-10,13,19-20,24H,7-8,11-12H2,1-4H3 UEQOVQIEAXKEQI-UHFFFAOYSA-N 159048 US9682966, 530::US10118915, Compound 530::US20250346584, Compound 530 Kappa-type opioid receptor Homo sapiens 5100 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159048&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264098 355041837 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572997 CO[C@H]1CN(CC[C@H]1NCC(C)C)C(\N)=C(\C=C(\C)N)/c1nc(C)no1 |r| InChI=1S/C18H32N6O2/c1-11(2)9-21-15-6-7-24(10-16(15)25-5)17(20)14(8-12(3)19)18-22-13(4)23-26-18/h8,11,15-16,21H,6-7,9-10,19-20H2,1-5H3 GDFFHAANTQRLIA-UHFFFAOYSA-N 159050 US9682966, 531::US20250346584, Compound 531 Kappa-type opioid receptor Homo sapiens 996 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159050&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264110 355041838 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572998 Cc1ccc2nc(N3CCC(CC3)NC3CCCCC3)c(cc2c1)-c1ccncn1 InChI=1S/C25H31N5/c1-18-7-8-23-19(15-18)16-22(24-9-12-26-17-27-24)25(29-23)30-13-10-21(11-14-30)28-20-5-3-2-4-6-20/h7-9,12,15-17,20-21,28H,2-6,10-11,13-14H2,1H3 XCLKLLPHNKLKII-UHFFFAOYSA-N 159053 US9682966, 532::US10118915, Compound 532::US20250346584, Compound 532 Kappa-type opioid receptor Homo sapiens 334 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159053&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264097 355041839 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1572999 Cc1ccc2nc(N3CCC(CC3)NC3CCCC3)c(cc2c1)-c1ccncn1 InChI=1S/C24H29N5/c1-17-6-7-22-18(14-17)15-21(23-8-11-25-16-26-23)24(28-22)29-12-9-20(10-13-29)27-19-4-2-3-5-19/h6-8,11,14-16,19-20,27H,2-5,9-10,12-13H2,1H3 HFRTXJNROMUROB-UHFFFAOYSA-N 159055 US9682966, 533::US10118915, Compound 533::US20250346584, Compound 533 Kappa-type opioid receptor Homo sapiens 263 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159055&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264108 355041840 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573000 CC(C)CNC1CCN(CC1)c1nc2ccc(C)cc2cc1-c1ccncn1 InChI=1S/C23H29N5/c1-16(2)14-25-19-7-10-28(11-8-19)23-20(22-6-9-24-15-26-22)13-18-12-17(3)4-5-21(18)27-23/h4-6,9,12-13,15-16,19,25H,7-8,10-11,14H2,1-3H3 NIMMIBHDASKSMM-UHFFFAOYSA-N 159057 US9682966, 534::US10118915, Compound 534::US20250346584, Compound 534 Kappa-type opioid receptor Homo sapiens 600 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159057&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264122 355041841 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573001 CO[C@H]1CN(CC[C@H]1NCC(C)C)C(\N)=C(\C=C(\C)N)/c1nc(no1)C1CC1 |r| InChI=1S/C20H34N6O2/c1-12(2)10-23-16-7-8-26(11-17(16)27-4)18(22)15(9-13(3)21)20-24-19(25-28-20)14-5-6-14/h9,12,14,16-17,23H,5-8,10-11,21-22H2,1-4H3 SCYIFGGKVUEUAU-UHFFFAOYSA-N 159065 US9682966, 535::US20250346584, Compound 535 Kappa-type opioid receptor Homo sapiens 465 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159065&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264101 355041842 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573002 Cc1noc(n1)-c1cc2ccc(Cl)cc2nc1N1CCC(CC1)NC1CCCCC1 InChI=1S/C23H28ClN5O/c1-15-25-23(30-28-15)20-13-16-7-8-17(24)14-21(16)27-22(20)29-11-9-19(10-12-29)26-18-5-3-2-4-6-18/h7-8,13-14,18-19,26H,2-6,9-12H2,1H3 ONWFDNFPLGFMOP-UHFFFAOYSA-N 159067 US9682966, 536::US10118915, Compound 536::US20250346584, Compound 536 Kappa-type opioid receptor Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159067&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264100 355041843 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573003 CO[C@H]1CN(CC[C@H]1NC1CCCCC1)c1nc2cc(Cl)ccc2cc1-c1nc(C)no1 |r| InChI=1S/C24H30ClN5O2/c1-15-26-24(32-29-15)19-12-16-8-9-17(25)13-21(16)28-23(19)30-11-10-20(22(14-30)31-2)27-18-6-4-3-5-7-18/h8-9,12-13,18,20,22,27H,3-7,10-11,14H2,1-2H3 DSJNDOJEJPDHMN-UHFFFAOYSA-N 159069 US9682966, 537::US10118915, Compound 537::US20250346584, Compound 537 Kappa-type opioid receptor Homo sapiens 12.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159069&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264105 355041844 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573004 CO[C@H]1CN(CC[C@H]1NCC(C)C)c1nc2cc(F)ccc2cc1-c1nc(C)no1 |r| InChI=1S/C22H28FN5O2/c1-13(2)11-24-18-7-8-28(12-20(18)29-4)21-17(22-25-14(3)27-30-22)9-15-5-6-16(23)10-19(15)26-21/h5-6,9-10,13,18,20,24H,7-8,11-12H2,1-4H3 WPKXBYGCBMGGDF-UHFFFAOYSA-N 159071 US9682966, 538::US10118915, Compound 538::US20250346584, Compound 538 Kappa-type opioid receptor Homo sapiens 970 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159071&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264111 355041845 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573005 COC1CN(CCC1NC1CCCCC1)c1ccc(C)cc1C(=O)OC InChI=1S/C21H32N2O3/c1-15-9-10-19(17(13-15)21(24)26-3)23-12-11-18(20(14-23)25-2)22-16-7-5-4-6-8-16/h9-10,13,16,18,20,22H,4-8,11-12,14H2,1-3H3 NCYUQGZUGWDJRI-UHFFFAOYSA-N 159076 US9682966, 539::US10118915, Compound 539::US20250346584, Compound 539 Kappa-type opioid receptor Homo sapiens 3700 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159076&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264109 355041846 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573006 CCOC(=O)c1cc(Br)cnc1N1CC[C@H](NC2CCCCC2)[C@@H](O)C1 |r| InChI=1S/C19H28BrN3O3/c1-2-26-19(25)15-10-13(20)11-21-18(15)23-9-8-16(17(24)12-23)22-14-6-4-3-5-7-14/h10-11,14,16-17,22,24H,2-9,12H2,1H3 OWMUORWJDKVTEO-UHFFFAOYSA-N 159079 US9682966, 540::US20250346584, Compound 540 Kappa-type opioid receptor Homo sapiens 16.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159079&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264107 355041847 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573007 CC(C)CNC1CCN(CC1)c1nc2cc(Cl)ccc2cc1-c1nc(C)no1 InChI=1S/C21H26ClN5O/c1-13(2)12-23-17-6-8-27(9-7-17)20-18(21-24-14(3)26-28-21)10-15-4-5-16(22)11-19(15)25-20/h4-5,10-11,13,17,23H,6-9,12H2,1-3H3 SOGCFXVRRLECKS-UHFFFAOYSA-N 159081 US9682966, 541::US10118915, Compound 541::US20250346584, Compound 541 Kappa-type opioid receptor Homo sapiens 45.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159081&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264116 355041848 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573008 Cc1noc(n1)-c1cc(C)cnc1N1CC[C@H](NC2CCCCC2)[C@@H](O)C1 |r| InChI=1S/C20H29N5O2/c1-13-10-16(20-22-14(2)24-27-20)19(21-11-13)25-9-8-17(18(26)12-25)23-15-6-4-3-5-7-15/h10-11,15,17-18,23,26H,3-9,12H2,1-2H3 GAFFUWMMWKYJFF-UHFFFAOYSA-N 159083 US9682966, 542::US10118915, Compound 542::US20250346584, Compound 542 Kappa-type opioid receptor Homo sapiens 32.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159083&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264112 355041849 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573009 Cc1noc(n1)-c1cc(C)c(C)nc1N1CC[C@H](NC2CCCCC2)[C@@H](O)C1 |r| InChI=1S/C21H31N5O2/c1-13-11-17(21-23-15(3)25-28-21)20(22-14(13)2)26-10-9-18(19(27)12-26)24-16-7-5-4-6-8-16/h11,16,18-19,24,27H,4-10,12H2,1-3H3 HRMRYKMHWNEXQL-UHFFFAOYSA-N 159091 US9682966, 543::US10118915, Compound 543::US20250346584, Compound 543 Kappa-type opioid receptor Homo sapiens 32.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159091&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264114 355041850 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4 1573010 COC(=O)c1cc(Br)cnc1N1CC[C@H](NC2CCCCC2)[C@@H](O)C1 |r| InChI=1S/C18H26BrN3O3/c1-25-18(24)14-9-12(19)10-20-17(14)22-8-7-15(16(23)11-22)21-13-5-3-2-4-6-13/h9-10,13,15-16,21,23H,2-8,11H2,1H3 AJYHHWYDOWTOKZ-UHFFFAOYSA-N 159094 US9682966, 544::US10118915, Compound 544::US20250346584, Compound 544Trans-rac Kappa-type opioid receptor Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=159094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2212&target=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=159094&enzyme=Kappa-type+opioid+receptor&column=ki&startPg=0&Increment=50&submit=Search 118264113 355041851 1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV 9D61,8VVG,8VVF,8VVE,9L60,8F7W,8FEG,7YIT,4DJH Kappa-type opioid receptor OPRK_HUMAN P41145 E5RHC9 Q499G4