BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
1573011	C[C@@]12C[C@@H]1N(C(=O)CNC(=O)c1ccc3c(c1)CCCO3)[C@H](C(=O)NCc1cc(C(=N)N)cs1)C2			785466	(1S,3S,5S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-2- ((chroman-6- carbonyl)glycyl)-5- methyl-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 1	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785466&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573012	C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)CNCC(=O)NCCOC[C@@]12C[C@@H]1N(C(=O)CNC(=O)CCCOc1ccccc1)[C@H](C(=O)N[C@H](C)c1cc(C(=N)N)cs1)C2			785467	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((4- phenoxybutanoyl)glycyl)- 5-((2-(2- (((2S,3S,4S,5S)- 2,3,4,5- tetrahydroxyhexyl)amino) acetamido)ethoxy) methyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 2	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785467&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573013	N=C(N)c1csc(CNC(=O)[C@@H]2C[C@@H](OC(F)F)CN2C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)c1			785468	(2S,4R)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-4- (difluoromethoxy)-1-((4- (4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 3	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785468&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573014	C[C@@H](NC(=O)[C@@H]1C[C@]2(C)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785469	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5- methyl-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 4	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785469&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573015	CC(NC(=O)C1CC(OC(F)F)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)c1cc(C(=N)N)cs1			785470	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((4- (4- (trifluoromethyl)phenoxy) benzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 5	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785470&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573016	Cc1ccc(Oc2ccc(C(=O)NCC(=O)N3C[C@H](OC(F)F)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)cc2)cc1			785471	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((4- (p- tolyloxy)benzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 6	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785471&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573017	CC(NC(=O)C1CC2(C)CC2N1C(=O)CNC(=O)c1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)c1cc(C(=N)N)cs1			785472	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-5-methyl-2- ((4-(p- tolyloxy)benzoyl)glycyl)- 2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 7	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785472&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573018	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785473	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((4- (4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 8	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785473&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573019	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785477	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 9	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785477&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573020	Cc1ccc(Oc2ccc(C(=O)NCC(=O)N3C[C@H](OC(F)F)C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)cc2)cc1			785479	(2S,4R)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-4- (difluoromethoxy)-1-((4- (p- tolyloxy)benzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 10	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785479&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573021	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785480	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 11	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785480&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573022	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2)c1cc(C(=N)N)cs1			785483	(2S,4R)-1-((9H- fluorene-3- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 12	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785483&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573023	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785484	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 13	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785484&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573024	Cc1ccc(Oc2ccc(C(=O)NCC(=O)N3C[C@@](F)(CF)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)cc2)cc1			785485	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)-1-((4-(p- tolyloxy)benzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 14	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785485&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573025	CC(NC(=O)C1CC(F)(CF)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)c1cc(C(=N)N)cs1			785486	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)-1-((4-(4- (trifluoromethyl)phenoxy) benzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 15	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785486&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573026	C[C@@H](NC(=O)[C@@H]1C[C@]2(C)C[C@@H]2N1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785487	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((4-(4- fluorophenoxy)benzoyl) glycyl)-5-methyl-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 16	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785487&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573027	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)C1			785489	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-1- ((4-(4- fluorophenoxy)benzoyl) glycyl)-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 17	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785489&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573028	COCC1(F)CC(C(=O)NC(C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2)C1			785491	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (methoxymethyl)-1-((4- (4- (trifluoromethyl)phenoxy) benzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 18	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785491&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573029	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(C)cc3)cc2)C1			785493	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (methoxymethyl)-1-((4- (p- tolyloxy)benzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 19	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785493&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573030	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785494	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 20	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785494&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573031	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(C(=N)N)cs1			785495	(S)-N-(R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 21	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785495&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573032	Cc1ccc(Oc2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)cc2)cc1			785497	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4-(p- tolyloxy)benzoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 22	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785497&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573033	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(Oc3ccc(F)cc3)cc1)OCCO2)c1cc(C(=N)N)cs1			785498	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 23	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785498&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573034	Cc1cc(C(=O)NCC(=O)N2C[C@H](OC(F)F)C[C@H]2C(=O)N[C@H](C)c2cc(C(=N)N)cs2)ccc1Oc1ccccc1			785499	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((3- methyl-4- phenoxybenzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 24	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785499&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573035	Cc1ccc(Oc2ccc(C(=O)NCC(=O)N3[C@H]4C[C@@]4(C)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)cc2C)cc1			785501	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-5-methyl-2- ((3-methyl-4-(p- tolyloxy)benzoyl)glycyl)- 2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 25	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785501&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573036	Cc1ccc(Oc2ccc(C(=O)NCC(=O)N3[C@H]4C[C@@]4(C)C[C@H]3C(=O)N[C@H](C)c3ccc(C(=N)N)s3)cc2)cc1			785502	(1S,3S,5S)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-5-methyl-2- ((4-(p- tolyloxy)benzoyl)glycyl)- 2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 26	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785502&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573037	Cc1cc(C(=O)NCC(=O)N2[C@H]3C[C@@]3(C)C[C@H]2C(=O)N[C@H](C)c2cc(C(=N)N)cs2)ccc1Oc1ccc(F)cc1			785503	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((4-(4- fluorophenoxy)-3- methylbenzoyl)glycyl)- 5-methyl-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 27	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785503&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573038	Cc1cc(C(=O)NCC(=O)N2[C@H]3C[C@@]3(C)C[C@H]2C(=O)N[C@H](C)c2cc(C(=N)N)cs2)ccc1Oc1ccccc1			785504	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-5-methyl-2- ((3-methyl-4- phenoxybenzoyl)glycyl)- 2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 28	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785504&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573039	C[C@@H](NC(=O)[C@@H]1C[C@]2(C)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1ccc(C(=N)N)s1			785505	(1S,3S,5S)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5- methyl-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 29	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785505&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573040	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1ccc(C(=N)N)s1			785506	(2S,4R)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 30	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785506&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573041	Cc1cc(C(=O)NCC(=O)N2[C@H]3C[C@@]3(C)C[C@H]2C(=O)N[C@H](C)c2ccc(C(=N)N)s2)ccc1Oc1ccccc1			785507	(1S,3S,5S)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-5-methyl-2- ((3-methyl-4- phenoxybenzoyl)glycyl)- 2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 31	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785507&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573042	Cc1cc(C(=O)NCC(=O)N2C[C@@](F)(CF)C[C@H]2C(=O)N[C@H](C)c2cc(C(=N)N)cs2)ccc1Oc1ccccc1			785508	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)-1-((3- methyl-4- phenoxybenzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 32	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785508&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573043	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1ccc(C(=N)N)s1			785509	(2S,4R)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 33	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785509&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573044	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccccc3)c(C)c2)C1			785510	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (methoxymethyl)-1-((3- methyl-4- phenoxybenzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 34	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785510&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573045	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CN)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785511	(2S,4S)-4- (aminomethyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoropyrrolidine-2- carboxamide::US20250346585, Compound 35	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785511&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573046	COC[C@@]1(F)C[C@@H](C(=O)NCc2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785512	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- ((dimethylamino)methyl)- 4-fluoropyrrolidine-2- carboxamide::US20250346585, Compound 36	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785512&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573047	C[C@@H](NC(=O)[C@@H]1C[C@@H](Oc2ccccc2)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785513	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- phenoxypyrrolidine-2- carboxamide::US20250346585, Compound 37	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785513&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573048	COC[C@@]12C[C@@H]1N(C(=O)CNC(=O)c1ccc(Oc3ccc(F)cc3)cc1)[C@H](C(=O)N[C@H](C)c1ccc(C(=N)N)s1)C2			785514	(1S,3S,5R)-N-(R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-2-((4-(4- fluorophenoxy)benzoyl) glycyl)-5- (methoxymethyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 38	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785514&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573049	CCc1ccc(Oc2ccc(C(=O)NCC(=O)N3C[C@H](OC(F)F)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)cc2)cc1			785515	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((4- (4- ethylphenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 39	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785515&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573050	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1ccc(C(=N)N)s1			785516	(2S,4R)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 40	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785516&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573051	C[C@@H](NC(=O)[C@@H]1C[C@]2(CO)C[C@@H]2N1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1ccc(C(=N)N)s1			785517	(1S,3S,5R)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-2-((4-(4- fluorophenoxy)benzoyl) glycyl)-5- (hydroxymethyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 41	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785517&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573052	C[C@@H](NC(=O)[C@@H]1C[C@]2(CO)C[C@@H]2N1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785518	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((4-(4- fluorophenoxy)benzoyl) glycyl)-5- (hydroxymethyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 42	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785518&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573053	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(Cl)cc2)cc1)c1cc(C(=N)N)cs1			785519	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- chlorophenoxy)benzoyl) glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 43	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785519&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573054	COC[C@@]12C[C@@H]1N(C(=O)CNC(=O)c1ccc(Oc3ccc(F)cc3)cc1)[C@H](C(=O)N[C@H](C)c1cc(C(=N)N)cs1)C2			785520	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((4-(4- fluorophenoxy)benzoyl) glycyl)-5- (methoxymethyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 44	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785520&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573055	C[C@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)C1			785521	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- methylpyrrolidine-2- carboxamide::US20250346585, Compound 45	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785521&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573056	C[C@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785522	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- methylpyrrolidine-2- carboxamide::US20250346585, Compound 46	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785522&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573057	CC(C)c1ccc(Oc2ccc(C(=O)NCC(=O)N3C[C@H](OC(F)F)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)cc2)cc1			785523	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((4- (4- isopropylphenoxy) benzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 47	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785523&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573058	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccccc4)cn2)OCCO3)c1			785524	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((5- phenylpicolinoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 48	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785524&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573059	N#Cc1ccc(Oc2ccc(C(=O)NCC(=O)N3C[C@H](OC(F)F)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)cc2)cc1			785525	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- cyanophenoxy)benzoyl) glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 49	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785525&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573060	N=C(N)c1csc(CNC(=O)[C@@H]2C[C@@H](OC(F)F)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785526	(2S,4R)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 50	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785526&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573061	C[C@@H](NC(=O)[C@@H]1C[C@@H](Oc2ccccc2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785527	(2S,4R)-N-((S)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- phenoxypyrrolidine-2- carboxamide::US20250346585, Compound 51	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785527&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573062	N=C(N)c1csc(CNC(=O)[C@@H]2C[C@](F)(CF)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785528	(2S,4R)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 52	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785528&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573063	C[C@@H](NC(=O)[C@@H]1C[C@]2(CO)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785529	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5- (hydroxymethyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 53	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785529&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573064	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785530	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- (methylsulfonyl) pyrrolidine- 2-carboxamide::US20250346585, Compound 54	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785530&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573065	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)c1			785531	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 55	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785531&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573066	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1ccc(C(=N)N)s1			785532	(S)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 56	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785532&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573067	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1ccc(C(=N)N)s1			785533	(2S,4R)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((4- (4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 57	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785533&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573068	COC[C@@]1(F)C[C@@H](C(=O)NCc2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785534	(2S,4R)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 58	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785534&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573069	Cc1ccccc1[C@H]5C[C@@H](C(=O)N[C@H](C)c2cc(/C(N)=N\N)cs2)N(C(=O)CNC(=O)c4ccc(Oc3ccc(F)cc3)cc4)C5			785535	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4-(o- tolyl)pyrrolidine-2- carboxamide::US20250346585, Compound 59	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785535&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573070	CC1(C)c2ccccc2-c2cc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)ccc21			785536	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((9,9- dimethyl-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 60	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785536&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573071	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785537	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 61	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785537&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573072	C[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785538	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- methylpyrrolidine-2- carboxamide::US20250346585, Compound 62	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785538&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573073	C[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)C1			785539	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- methylpyrrolidine-2- carboxamide::US20250346585, Compound 63	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785539&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573074	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(C3CC3)cc2)cc1)c1cc(C(=N)N)cs1			785540	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- cyclopropylphenoxy) benzoyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 64	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785540&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573075	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(C(F)F)cc2)cc1)c1cc(C(=N)N)cs1			785541	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((4- (4- (difluoromethyl)phenoxy) benzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 65	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785541&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573076	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1cc3ccc1CCc1ccc(cc1)CC3)OCCO2)c1cc(C(=N)N)cs1			785542	(S)-7-((1,4(1,4)- dibenzenacyclo- hexaphane-12- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 66	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785542&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573077	C[C@@H](NC(=O)[C@@H]1C[C@]2(C)C[C@@H]2N1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1ccc(C(=N)N)s1			785543	(1S,3S,5S)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-2-((4-(4- fluorophenoxy)benzoyl) glycyl)-5-methyl-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 67	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785543&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573078	COC[C@@]1(F)C[C@@H](C(=O)NCc2ccc(C(=N)N)s2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)C1			785544	(2S,4R)-N-((5- carbamimidoylthiophen- 2-yl)methyl)-4-fluoro-1- ((4-(4- fluorophenoxy)benzoyl) glycyl)-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 68	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785544&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573079	C[C@@H](NC(=O)[C@@H]1C[C@]2(COCCN)CC2N1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785545	(1S,3S,5R)-5-((2- aminoethoxy)methyl)- N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((4-(4- fluorophenoxy)benzoyl) glycyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 69	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785545&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573080	CO[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)C1			785546	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- methoxypyrrolidine-2- carboxamide::US20250346585, Compound 70	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785546&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573081	CO[C@@H]1C[C@@H](C(=O)N(N)[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785547	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- methoxypyrrolidine-2- carboxamide::US20250346585, Compound 71	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785547&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573082	COC[C@@]12C[C@@H]1N(C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)[C@H](C(=O)N[C@H](C)c1cc(C(=N)N)cs1)C2			785548	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5- (methoxymethyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 72	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785548&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573083	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(F)cc4)cc2)OCCO3)c1			785549	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4'- fluoro-[1,1'-biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 73	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785549&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573084	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccccc4)cc2F)OCCO3)c1			785550	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2- fluoro-4- phenoxybenzoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 74	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785550&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573085	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(Br)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785551	(S)-N-((4- bromothiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 75	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785551&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573086	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(-c3cc(C(F)(F)F)[nH]n3)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785552	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-((4-(5- (trifluoromethyl)-1H- pyrazol-3-yl)thiophen-2- yl)methyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 76	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785552&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573087	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccccc4)cc2)OCCO3)c1			785553	(S)-7-(([1,1'-biphenyl]- 4-carbonyl)glycyl)-N- ((4- carbamimidoylthiophen- 2-yl)methyl)-1,4-dioxa- 7-azaspiro[4.4]nonane- 8-carboxamide::US20250346585, Compound 77	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785553&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573088	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3cc4ccccc4cc3c1)OCCO2)c1cc(C(=N)N)cs1			785554	(S)-7-((anthracene-2- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 78	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785554&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573089	COC[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)C1			785555	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 79	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785555&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573090	COC[C@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)C1			785556	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 80	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785556&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573091	C[C@@H](NC(=O)[C@@H]1C[C@@H](c2ccccc2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785557	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- phenylpyrrolidine-2- carboxamide::US20250346585, Compound 81	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785557&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573092	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(C(F)(F)c3ccccc3)cc1)OCCO2)c1cc(C(=N)N)cs1			785558	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4- (difluoro(phenyl)methyl) benzoyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 82	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785558&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573093	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccccc4)cc2F)OCCO3)c1			785559	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((3- fluoro-[1,1'-biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 83	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785559&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573094	C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)CNCC(=O)NCCOC[C@@]12CC1N(C(=O)CNC(=O)c1ccc(Oc3ccc(F)cc3)cc1)[C@H](C(=O)N[C@H](C)c1cc(C(=N)N)cs1)C2			785560	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((4-(4- fluorophenoxy)benzoyl) glycyl)-5-((2-(2- (((2S,3S,4S,5S)- 2,3,4,5- tetrahydroxyhexyl)amino) acetamido)ethoxy) methyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 84	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785560&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573095	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(Oc3ccc(F)cc3)cc1)OCCO2)c1ccc(C(=N)N)s1			785561	(S)-N-((R)-1-(5- carbamimidoylthiophen- 2-yl)ethyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 85	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785561&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573096	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(-c2ncc[nH]2)cs1			785562	(2S,4R)-N-((R)-1-(4- (1H-imidazol-2- yl)thiophen-2-yl)ethyl)- 4-(difluoromethoxy)-1- ((4-(4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 86	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785562&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573097	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2ncc[nH]2)cs1			785563	(S)-N-((R)-1-(4-(1H- imidazol-2-yl)thiophen- 2-yl)ethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 87	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785563&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573098	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4=O)OCCO3)c1			785564	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((9-oxo- 9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 88	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785564&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573099	C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)CNCC(=O)NCCOC[C@@]12CC1N(C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)[C@H](C(=O)N[C@H](C)c1cc(C(=N)N)cs1)C2			785565	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5-((2- (2-(((2S,3S,4S,5S)- 2,3,4,5- tetrahydroxyhexyl)amino) acetamido)ethoxy) methyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 89	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785565&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573100	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccccc3)cc1)OCCO2)c1cc(C(=N)N)cs1			785566	(S)-7-(([1,1'-biphenyl]- 4-carbonyl)glycyl)-N- ((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 90	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785566&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573101	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2cncnc2)cs1			785568	(S)-7-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-N-((R)- 1-(4-(pyrimidin-5- yl)thiophen-2-yl)ethyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 91	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785568&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573102	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2nn[nH]n2)cs1			785569	(S)-N-((R)-1-(4-(2H- tetrazol-5-yl)thiophen- 2-yl)ethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 92	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785569&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573103	C[C@@H](NC(=O)[C@@H]1C[C@H](C2CCCCC2)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785570	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- cyclohexyl-1-((4-(4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 93	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785570&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573104	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(C)C)OCCO2)c1cc(C(=N)N)cs1			785571	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- dimethyl-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 94	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785571&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573105	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1-3)OCCO2)c1cc(C(=N)N)cs1			785576	(S)-7-((biphenylene-2- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 95	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785576&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573106	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2c[nH]cn2)cs1			785577	(S)-N-((R)-1-(4-(1H- imidazol-4-yl)thiophen- 2-yl)ethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 96	Complement C1s subcomponent	Homo sapiens		 550							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785577&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573107	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2cc[nH]n2)cs1			785578	(S)-N-((R)-1-(4-(1H- pyrazol-3-yl)thiophen-2- yl)ethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 97	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785578&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573108	C[C@@H](NC(=O)[C@@H]1C[C@H](C2CCCCC2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785579	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- cyclohexyl-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 98	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785579&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573109	CC1c2ccccc2-c2cc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)ccc21			785580	(8S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9- methyl-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 99	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785580&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573110	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2cnc(N)nc2)cs1			785581	(S)-N-((R)-1-(4-(2- aminopyrimidin-5- yl)thiophen-2-yl)ethyl)- 7-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 100	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785581&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573111	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccc(F)cc3)cc1)OCCO2)c1cc(C(=N)N)cs1			785582	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4'-fluoro- [1,1'-biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 101	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785582&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573112	Cc1ccc(-c2cnc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)c(F)c2)cc1			785583	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((3- fluoro-5-(p- tolyl)picolinoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 102	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785583&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573113	Nc1cccc(-c2csc(CNC(=O)[C@@H]3CC4(CN3C(=O)CNC(=O)c3ccc(Oc5ccc(F)cc5)cc3)OCCO4)c2)n1			785584	(S)-N-((4-(6- aminopyridin-2- yl)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 103	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785584&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573114	Cn1ccc2cc(-c3ccc(C(=O)NCC(=O)N4CC5(C[C@H]4C(=O)NCc4cc(C(=N)N)cs4)OCCO5)cc3)ccc21			785585	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4-(1- methyl-1H-indol-5- yl)benzoyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 104	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785585&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573115	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ncc(-c4ccccc4)cc2F)OCCO3)c1			785586	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((3- fluoro-5- phenylpicolinoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 105	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785586&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573116	C[C@@H](NC(=O)[C@@H]1C[C@](F)(COCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785587	18-(((S)-4-((2- (((3R,5S)-5-(((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 3-fluoro-1-((4-(4- fluorophenoxy)benzoyl) glycyl)pyrrolidin-3- yl)methoxy)ethyl)amino)- 1-carboxy-4- oxobutyl)amino)-18- oxooctadecanoic acid::US20250346585, Compound 106	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785587&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573117	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(F)cc4F)cc2)OCCO3)c1			785588	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2',4'- difluoro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 107	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785588&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573118	Cc1ccc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)cc2)cc1			785592	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4'- methyl-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 108	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785592&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573119	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1cccc(-c3ccccc3)c1)OCCO2)c1cc(C(=N)N)cs1			785593	(S)-7-(([1,1'-biphenyl]- 3-carbonyl)glycyl)-N- ((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 109	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785593&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573120	CC1c2ccccc2-c2cc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)ccc21			785594	(8S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((9- methyl-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 110	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785594&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573121	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3)OCCO2)c1cc(C(=N)N)cs1			785595	(S)-7-((9H-fluorene-3- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 111	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785595&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573122	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1cccc(-c3ccc(F)cc3)c1)OCCO2)c1cc(C(=N)N)cs1			785596	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4'-fluoro- [1,1'-biphenyl]-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 112	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785596&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573123	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2ncco2)cs1			785597	(S)-7-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-N-((R)- 1-(4-(oxazol-2- yl)thiophen-2-yl)ethyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 113	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785597&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573124	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2nccs2)cs1			785598	(S)-7-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-N-((R)- 1-(4-(thiazol-2- yl)thiophen-2-yl)ethyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 114	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785598&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573125	Cc1cc(C(=O)NCC(=O)N2CC3(C[C@H]2C(=O)NCc2cc(C(=N)N)cs2)OCCO3)ccc1-c1ccccc1			785599	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2- methyl-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 115	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785599&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573126	N=C(N)c1csc(CNC(=O)C2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(C(F)(F)F)cc4)cc2)OCCO3)c1			785600	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4'- (trifluoromethyl)-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 116	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785600&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573127	COC[C@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785601	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 117	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785601&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573128	COC[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785604	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 118	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785604&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573129	Cc1ccccc1[C@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785605	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4-(o- tolyl)pyrrolidine-2- carboxamide::US20250346585, Compound 119	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785605&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573130	Cc1ccc(-c2cccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)c2)cc1			785608	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4'- methyl-[1,1'-biphenyl]- 3-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 120	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785608&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573131	C[C@@H](NC(=O)[C@@H]1C[C@]2(C)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)C(F)(F)c1ccccc1-2)c1cc(C(=N)N)cs1			785609	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-2- carbonyl)glycyl)-5- methyl-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 121	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785609&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573132	Nc1ncccc1-c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785610	(S)-N-((4-(2- aminopyridin-3- yl)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 122	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785610&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573133	Nc1ccc(-c2csc(CNC(=O)[C@@H]3CC4(CN3C(=O)CNC(=O)c3ccc(Oc5ccc(F)cc5)cc3)OCCO4)c2)cn1			785611	(S)-N-((4-(6- aminopyridin-3- yl)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 123	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785611&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573134	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cccs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785615	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-(thiophen-2- ylmethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 124	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785615&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573135	CC(=O)ONC(=N)c1csc([C@@H](C)NC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)c1			785616	(S)-N-((R)-1-(4-(N- acetoxycarbamimidoyl) thiophen-2-yl)ethyl)-7- ((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 125	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785616&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573136	Cc1ccc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)cc2)cc1			785617	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4'- methyl-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 126	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785617&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573137	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3F)OCCO2)c1cc(C(=N)N)cs1			785618	(8S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9-fluoro- 9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 127	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785618&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573138	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(C(=N)NO)cs1			785619	(S)-7-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-N-((R)- 1-(4-(N- hydroxycarbamimidoyl) thiophen-2-yl)ethyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 128	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785619&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573139	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2cocn2)cs1			785620	(S)-7-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-N-((R)- 1-(4-(oxazol-4- yl)thiophen-2-yl)ethyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 129	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785620&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573140	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2nnc[nH]2)cs1			785621	(S)-N-((R)-1-(4-(4H- 1,2,4-triazol-3- yl)thiophen-2-yl)ethyl)- 7-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 130	Complement C1s subcomponent	Homo sapiens		 550							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785621&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573141	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc(C(F)(F)c2ccccc2)cc1)c1cc(C(=N)N)cs1			785622	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4- (difluoro(phenyl)methyl) benzoyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 131	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785622&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573142	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(C)C)c1cc(C(=N)N)cs1			785623	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1- ((9,9-dimethyl-9H- fluorene-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 132	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785623&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573143	C[C@@H](NC(=O)[C@@H]1C[C@](F)(COCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785626	18-(((S)-4-((2- (((3R,5S)-5-(((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-3- fluoropyrrolidin-3- yl)methoxy)ethyl)amino)- 1-carboxy-4- oxobutyl)amino)-18- oxooctadecanoic acid::US20250346585, Compound 133	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785626&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573144	CC(C)OC(=O)/N=C(/N)c1csc([C@@H](C)NC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)c1			785627	(E)-isopropyl (amino(5- ((R)-1-((S)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 134	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785627&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573145	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1ccc(-c2ncc[nH]2)s1			785628	(S)-N-((R)-1-(5-(1H- imidazol-2-yl)thiophen- 2-yl)ethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 135	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785628&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573146	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc(C(F)(F)c3ccccc3)cc2)C1			785629	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4- (difluoro(phenyl)methyl) benzoyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 136	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785629&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573147	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3oc4ccccc4c3c1)OCCO2)c1cc(C(=N)N)cs1			785630	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 137	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785630&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573148	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)C(F)(F)c1ccccc1-3)OCCO2)c1cc(C(=N)N)cs1			785632	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-9H-fluorene-2- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 138	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785632&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573149	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(C)C)C1			785633	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- dimethyl-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 139	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785633&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573150	Cn1ncc2cc(-c3ccc(C(=O)NCC(=O)N4CC5(C[C@H]4C(=O)NCc4cc(C(=N)N)cs4)OCCO5)cc3)ccc21			785634	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4-(1- methyl-1H-indazol-5- yl)benzoyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 140	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785634&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573151	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccccc4)c(F)c2)OCCO3)c1			785635	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2- fluoro-[1,1'-biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 141	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785635&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573152	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(NC3=NCCCN3)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785636	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-((4-((1,4,5,6- tetrahydropyrimidin-2- yl)amino)thiophen-2- yl)methyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 142	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785636&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573153	NS(=O)(=O)c1cncc(-c2csc(CNC(=O)[C@@H]3CC4(CN3C(=O)CNC(=O)c3ccc(Oc5ccc(F)cc5)cc3)OCCO4)c2)c1			785637	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-((4-(5- sulfamoylpyridin-3- yl)thiophen-2- yl)methyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 143	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785637&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573154	N=C(N)c1cc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccccc4)cn2)OCCO3)cs1			785638	(S)-N-((5- carbamimidoylthiophen- 3-yl)methyl)-7-((5- phenylpicolinoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 144	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785638&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573155	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4cc5ccccc5s4)cc2)OCCO3)c1			785639	(S)-7-((4- (benzo[b]thiophen-2- yl)benzoyl)glycyl)-N- ((4- carbamimidoylthiophen- 2-yl)methyl)-1,4-dioxa- 7-azaspiro[4.4]nonane- 8-carboxamide::US20250346585, Compound 145	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785639&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573156	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2cccc(-c4ccccc4)n2)OCCO3)c1			785640	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((6- phenylpicolinoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 146	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785640&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573157	N=C(N)c1cc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccccc4)cc2)OCCO3)cs1			785641	(S)-7-(([1,1'-biphenyl]- 4-carbonyl)glycyl)-N- ((5- carbamimidoylthiophen- 3-yl)methyl)-1,4-dioxa- 7-azaspiro[4.4]nonane- 8-carboxamide::US20250346585, Compound 147	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785641&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573158	COC(=O)/N=C(/N)c1csc([C@@H](C)NC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)c1			785642	(E)-methyl (amino(5- ((R)-1-((S)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 148	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785642&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573159	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(/C(N)=N\C(=O)Oc2ccccc2)cs1			785643	(E)-phenyl (amino(5- ((R)-1-((S)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 149	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785643&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573160	C[C@@H](NC(=O)[C@H]1CN(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)[C@@](F)(COCCCCCCCC(=O)O)C1)c1cc(C(=N)N)cs1			785644	8-(((3R,5S)-5-(((R)-1- (4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-3- fluoropyrrolidin-3- yl)methoxy)octanoic acid::US20250346585, Compound 150	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785644&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573161	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccc(Cl)cn3)cc1)OCCO2)c1cc(C(=N)N)cs1			785645	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4-(5- chloropyridin-2- yl)benzoyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 151	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785645&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573162	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(-c2cn[nH]n2)cs1			785646	(S)-N-((R)-1-(4-(2H- 1,2,3-triazol-4- yl)thiophen-2-yl)ethyl)- 7-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 152	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785646&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573163	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(C)C)c1cc(C(=N)N)cs1			785647	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- dimethyl-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 153	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785647&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573164	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc(C(F)(F)c2ccccc2)cc1)c1cc(C(=N)N)cs1			785648	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4- (difluoro(phenyl)methyl) benzoyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 154	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785648&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573165	N=C(N)c1cc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(F)cc4F)cc2)OCCO3)cs1			785649	(S)-N-((5- carbamimidoylthiophen- 3-yl)methyl)-7-((2',4'- difluoro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 155	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785649&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573166	CO[C@@H]1C[C@@H](C(=O)NCc2cc(-c3c[nH]c([N+](=O)[O-])n3)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)C1			785650	(2S,4R)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4-methoxy-N- ((4-(2-nitro-1H- imidazol-4-yl)thiophen- 2-yl)methyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 156	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785650&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573167	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(-c3ncc[nH]3)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785651	(S)-N-((4-(1H-imidazol- 2-yl)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 157	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785651&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573168	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccc(F)cc3F)cc1)OCCO2)c1cc(C(=N)N)cs1			785652	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((2',4'- difluoro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 158	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785652&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573169	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785653	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (trifluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 159	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785653&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573170	C[C@@H](NC(=O)[C@@H]1C[C@@H](C2OCCCO2)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785654	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-(1,3- dioxan-2-yl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 160	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785654&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573171	C[C@@H](NC(=O)[C@@H]1C[C@H](C2OCCCO2)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785655	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-(1,3- dioxan-2-yl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamide::US20250346585, Compound 161	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785655&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573172	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3O)OCCO2)c1cc(C(=N)N)cs1			785656	(8S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9- hydroxy-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 162	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785656&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573173	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccc(F)cc3)cn1)OCCO2)c1cc(C(=N)N)cs1			785657	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((5-(4- fluorophenyl)picolinoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 163	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785657&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573174	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccc(F)cn3)cc1)OCCO2)c1cc(C(=N)N)cs1			785659	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4-(5- fluoropyridin-2- yl)benzoyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 164	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785659&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573175	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccsc4)cc2)OCCO3)c1			785660	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4- (thiophen-3- yl)benzoyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 165	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785660&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573176	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3cc(F)ccc3F)cc1)OCCO2)c1cc(C(=N)N)cs1			785661	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((2',5'- difluoro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 166	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785661&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573177	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccccc3)cn1)OCCO2)c1cc(C(=N)N)cs1			785662	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((5- phenylpicolinoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 167	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785662&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573178	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc(C(F)(F)c2ccccc2)cc1)c1cc(C(=N)N)cs1			785663	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4- (difluoro(phenyl)methyl) benzoyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 168	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785663&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573179	Cc1ccc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)cc2)c(C)c1			785664	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((2',4'- dimethyl-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 169	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785664&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573180	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3[nH]c4ccccc4c3c1)OCCO2)c1cc(C(=N)N)cs1			785665	(S)-7-((9H-carbazole-3- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 170	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785665&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573181	C[C@@H](NC(=O)[C@@H]1C[C@H](c2nccs2)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785666	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4-(thiazol-2- yl)pyrrolidine-2- carboxamide::US20250346585, Compound 171	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785666&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573182	C[C@@H](NC(=O)[C@@H]1C[C@H](c2nccs2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785667	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (thiazol-2-yl)pyrrolidine- 2-carboxamide::US20250346585, Compound 172	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785667&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573183	Cc1cnc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)cc2)c(C)c1			785668	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4-(3,5- dimethylpyridin-2- yl)benzoyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 173	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785668&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573184	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccc(Cl)cc3F)cc1)OCCO2)c1cc(C(=N)N)cs1			785669	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4'- chloro-2'-fluoro-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 174	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785669&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573185	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccc(F)cc3)c(F)c1)OCCO2)c1cc(C(=N)N)cs1			785670	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((2,4'- difluoro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 175	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785670&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573186	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(-c3ccc(F)cc3Cl)cc1)OCCO2)c1cc(C(=N)N)cs1			785671	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((2'- chloro-4'-fluoro-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 176	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785671&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573187	Cc1cccc2c1-c1cc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)ccc1C2(F)F			785672	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-5-methyl-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 177	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785672&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573188	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(C)C)c1cc(C(=N)N)cs1			785673	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- dimethyl-9H-fluorene-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 178	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785673&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573189	Cc1cc(C(=O)NCC(=O)N2CC3(C[C@H]2C(=O)N[C@H](C)c2cc(C(=N)N)cs2)OCCO3)cc2c1C(F)(F)c1ccccc1-2			785674	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-1-methyl-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 179	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785674&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573190	Cc1ccc2c(c1)-c1cc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)ccc1C2(F)F			785675	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-6-methyl-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 180	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785675&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573191	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1cc(F)c(-c3ccc(F)cc3)cn1)OCCO2)c1cc(C(=N)N)cs1			785676	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4-fluoro- 5-(4- fluorophenyl)picolinoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 181	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785676&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573192	Cc1cccc2c1C(F)(F)c1ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)cc1-2			785677	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-8-methyl-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4 ]nonane-8- carboxamide::US20250346585, Compound 182	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785677&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573193	CS(=O)(=O)c1ccc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)cc2)cc1			785678	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4'- (methylsulfonyl)-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 183	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785678&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573194	Nc1csc(-c2csc(CNC(=O)[C@@H]3CC4(CN3C(=O)CNC(=O)c3ccc(Oc5ccc(F)cc5)cc3)OCCO4)c2)n1			785679	(S)-N-((4-(4- aminothiazol-2- yl)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 184	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785679&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573195	Nc1cnc(-c2csc(CNC(=O)[C@@H]3CC4(CN3C(=O)CNC(=O)c3ccc(Oc5ccc(F)cc5)cc3)OCCO4)c2)s1			785680	(S)-N-((4-(5- aminothiazol-2- yl)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 185	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785680&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573196	Nc1nc(-c2csc(CNC(=O)[C@@H]3CC4(CN3C(=O)CNC(=O)c3ccc(Oc5ccc(F)cc5)cc3)OCCO4)c2)cs1			785681	(S)-N-((4-(2- aminothiazol-4- yl)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 186	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785681&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573197	Nc1ncc(-c2csc(CNC(=O)[C@@H]3CC4(CN3C(=O)CNC(=O)c3ccc(Oc5ccc(F)cc5)cc3)OCCO4)c2)s1			785682	(S)-N-((4-(2- aminothiazol-5- yl)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 187	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785682&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573198	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4cc(F)ccc4F)cc2)OCCO3)c1			785683	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2',5'- difluoro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 188	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785683&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573199	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4cc(F)cc(F)c4)cc2)OCCO3)c1			785684	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((3',5'- difluoro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 189	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785684&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573200	Cc1ccc2c(c1)C(F)(F)c1ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)cc1-2			785685	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-7-methyl-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 190	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785685&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573201	COc1ccc2c(c1)C(F)(F)c1ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)cc1-2			785686	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-7-methoxy-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 191	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785686&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573202	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccc(Cl)cc1C3(F)F)OCCO2)c1cc(C(=N)N)cs1			785687	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((7-chloro- 9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 192	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785687&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573203	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccc(F)cc1C3(F)F)OCCO2)c1cc(C(=N)N)cs1			785688	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((7,9,9- trifluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 193	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785688&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573204	C[C@@H](NC(=O)[C@@H]1C[C@](F)(COCCCCCCCCCC(=O)O)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785689	10-(((3R,5S)-5-(((R)-1- (4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-3- fluoropyrrolidin-3- yl)methoxy)decanoic acid::US20250346585, Compound 194	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785689&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573205	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4cnc5[nH]ccc5c4)cc2)OCCO3)c1			785690	(S)-7-((4-(1H- pyrrolo[2,3-b]pyridin-5- yl)benzoyl)glycyl)-N- ((4- carbamimidoylthiophen- 2-yl)methyl)-1,4-dioxa- 7-azaspiro[4.4]nonane- 8-carboxamide::US20250346585, Compound 195	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785690&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573206	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4c(F)cccc4F)cc2)OCCO3)c1			785691	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2',6'- difluoro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 196	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785691&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573207	Cc1cccc(C)c1-c1ccc(C(=O)NCC(=O)N2CC3(C[C@H]2C(=O)NCc2cc(C(=N)N)cs2)OCCO3)cc1			785692	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2',6'- dimethyl-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 197	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785692&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573208	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4cnn(Cc5ccccc5)c4)cc2)OCCO3)c1			785693	(S)-7-((4-(1-benzyl-1H- pyrazol-4- yl)benzoyl)glycyl)-N- ((4- carbamimidoylthiophen- 2-yl)methyl)-1,4-dioxa- 7-azaspiro[4.4]nonane- 8-carboxamide::US20250346585, Compound 198	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785693&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573209	Cc1cc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)cc2)ccc1F			785694	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4'- fluoro-3'-methyl-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 199	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785694&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573210	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)OCCO2)c1cc(C(N)=O)cs1			785695	(S)-N-((R)-1-(4- carbamoylthiophen-2- yl)ethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 200	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785695&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573211	C[C@@H](NC(=O)[C@@H]1C[C@](F)(COCCCCCC(=O)O)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785696	6-(((3R,5S)-5-(((R)-1- (4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-3- fluoropyrrolidin-3- yl)methoxy)hexanoic acid::US20250346585, Compound 201	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785696&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573212	C[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785697	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoropyrrolidine-2- carboxamide::US20250346585, Compound 202	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785697&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573213	C=C1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785698	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- methylenepyrrolidine-2- carboxamide::US20250346585, Compound 203	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785698&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573214	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3OC(F)F)OCCO2)c1cc(C(=N)N)cs1			785699	(8S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9- (difluoromethoxy)-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 204	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785699&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573215	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2oc3ccccc3c2c1)c1cc(C(=N)N)cs1			785700	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 205	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785700&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573216	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2cc3ccccc3cc2c1)c1cc(C(=N)N)cs1			785701	(2S,4R)-1- ((anthracene-2- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 206	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785701&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573217	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(F)c(F)c4)cc2)OCCO3)c1			785702	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((3',4'- difluoro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 207	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785702&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573218	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4cc(Cl)cc(Cl)c4)cc2)OCCO3)c1			785703	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((3',5'- dichloro-[1,1'-biphenyl]- 4-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 208	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785703&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573219	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(F)nc4)cc2)OCCO3)c1			785704	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4-(6- fluoropyridin-3- yl)benzoyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 209	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785704&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573220	Cc1ccc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)cc2)cc1F			785705	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((3'- fluoro-4'-methyl-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 210	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785705&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573221	Cc1nc(F)ccc1-c1ccc(C(=O)NCC(=O)N2CC3(C[C@H]2C(=O)NCc2cc(C(=N)N)cs2)OCCO3)cc1			785706	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4-(6- fluoro-2-methylpyridin- 3-yl)benzoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 211	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785706&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573222	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(F)c(C(=O)O)c4)cc2)OCCO3)c1			785707	(S)-4'-((2-(8-(((4- carbamimidoylthiophen- 2- yl)methyl)carbamoyl)- 1,4-dioxa-7- azaspiro[4.4]nonan-7- yl)-2- oxoethyl)carbamoyl)-4- fluoro-[1,1'-biphenyl]-3- carboxylic acid::US20250346585, Compound 212	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785707&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573223	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(C(=O)O)c(F)c4)cc2)OCCO3)c1			785708	(S)-4'-((2-(8-(((4- carbamimidoylthiophen- 2- yl)methyl)carbamoyl)- 1,4-dioxa-7- azaspiro[4.4]nonan-7- yl)-2- oxoethyl)carbamoyl)-3- fluoro-[1,1'-biphenyl]-4- carboxylic acid::US20250346585, Compound 213	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785708&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573224	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(C(=O)O)cc4)cc2)OCCO3)c1			785710	(S)-4'-((2-(8-(((4- carbamimidoylthiophen- 2- yl)methyl)carbamoyl)- 1,4-dioxa-7- azaspiro[4.4]nonan-7- yl)-2- oxoethyl) carbamoyl)- [1,1'-biphenyl]-4- carboxylic acid::US20250346585, Compound 214	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785710&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573225	CS(=O)(=O)c1ccc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)cc2)c(F)c1			785711	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2'- fluoro-4'- (methylsulfonyl)-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 215	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785711&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573226	CC(C)S(=O)(=O)c1ccc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)cc2)cc1			785712	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4'- (isopropylsulfonyl)- [1,1'-biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 216	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785712&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573227	COc1ccc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)cc2)cc1			785713	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4'- methoxy-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 217	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785713&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573228	C[C@@H](NC(=O)[C@@H]1C[C@@H](c2ccccc2)CN1C(=O)CNC(=O)c1ccc2oc3ccccc3c2c1)c1cc(C(=N)N)cs1			785714	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- phenylpyrrolidine-2- carboxamide::US20250346585, Compound 218	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785714&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573229	COC[C@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3oc4ccccc4c3c2)C1			785715	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 219	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785715&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573230	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2oc3ccccc3c2c1)c1cc(C(=N)N)cs1			785716	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 220	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785716&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573231	CO[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3oc4ccccc4c3c2)C1			785717	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- methoxypyrrolidine-2- carboxamide::US20250346585, Compound 221	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785717&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573232	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3oc4ccccc4c3c2)C1			785718	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 222	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785718&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573233	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2oc3ccccc3c2c1)c1cc(C(=N)N)cs1			785719	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 223	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785719&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573234	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3cc4ccccc4cc3c2)C1			785720	(2S,4R)-1- ((anthracene-2- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 224	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785720&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573235	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1cc(F)ccc1C3(F)F)OCCO2)c1cc(C(=N)N)cs1			785721	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((6,9,9- trifluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 225	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785721&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573236	C[C@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3oc4ccccc4c3c2)C1			785722	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- methylpyrrolidine-2- carboxamide::US20250346585, Compound 226	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785722&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573237	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(F)cc4C(=O)O)cc2)OCCO3)c1			785723	(S)-4'-((2-(8-(((4- carbamimidoylthiophen- 2- yl)methyl)carbamoyl)- 1,4-dioxa-7- azaspiro[4.4]nonan-7- yl)-2- oxoethyl)carbamoyl)-4- fluoro-[1,1'-biphenyl]-2- carboxylic acid::US20250346585, Compound 227	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785723&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573238	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CN2Cc4cc(-c5ccc(F)cc5F)ccc4C2=O)OCCO3)c1			785724	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-(2-(5- (2,4-difluorophenyl)-1- oxoisoindolin-2- yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 228	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785724&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573239	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CN2Cc4ccc(-c5ccc(F)cc5F)cc4C2=O)OCCO3)c1			785725	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-(2-(6- (2,4-difluorophenyl)-1- oxoisoindolin-2- yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 229	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785725&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573240	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CN2Cc4cc(-c5ccc(F)cc5)ccc4C2=O)OCCO3)c1			785726	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-(2-(5-(4- fluorophenyl)-1- oxoisoindolin-2- yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 230	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785726&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573241	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CN2Cc4cc(-c5ccccc5)ccc4C2=O)OCCO3)c1			785727	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-(2-(1- oxo-5-phenylisoindolin- 2-yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 231	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785727&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573242	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(/C(N)=N\C(=O)OC)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785728	(E)-methyl (amino(5- ((R)-1-((2S,4R)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 232	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785728&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573243	COC(=O)/N=C(/N)c1csc([C@@H](C)NC(=O)[C@@H]2C[C@](F)(CF)CN2C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)c1			785729	(E)-methyl (amino(5- ((R)-1-((2S,4R)-4- fluoro-4-(fluoromethyl)- 1-((4-(4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 233	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785729&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573244	CCCCCCOC(=O)/N=C(/N)c1csc([C@@H](C)NC(=O)[C@@H]2C[C@](F)(CF)CN2C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)c1			785730	(E)-hexyl (amino(5- ((R)-1-((2S,4R)-4- fluoro-4-(fluoromethyl)- 1-((4-(4- fluorophenoxy)benzoyl) glycyl)pyrrolidine-2- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 234	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785730&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573245	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2cc3ccccc3cc2c1)c1cc(C(=N)N)cs1			785731	(2S,4R)-1- ((anthracene-2- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 235	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785731&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573246	Cc1ccccc1[C@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3oc4ccccc4c3c2)C1			785732	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4-(o- tolyl)pyrrolidine-2- carboxamide::US20250346585, Compound 236	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785732&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573247	Cc1cc2c(cc1C(=O)NCC(=O)N1CC3(C[C@H]1C(=O)N[C@H](C)c1cc(C(=N)N)cs1)OCCO3)-c1ccccc1C2(F)F			785733	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-2-methyl-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 237	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785733&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573248	CCS(=O)(=O)[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785734	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (ethylsulfonyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 238	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785734&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573249	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2cc3ccccc3cc2c1)c1cc(C(=N)N)cs1			785735	(2S,4R)-1- ((anthracene-2- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 239	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785735&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573250	Cc1ccc(-c2ccc3c(c2)CN(CC(=O)N2CC4(C[C@H]2C(=O)NCc2cc(C(=N)N)cs2)OCCO4)C3=O)c(C)c1			785736	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-(2-(5- (2,4-dimethylphenyl)-1- oxoisoindolin-2- yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 240	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785736&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573251	COc1cccc(F)c1-c1ccc(C(=O)NCC(=O)N2CC3(C[C@H]2C(=O)NCc2cc(C(=N)N)cs2)OCCO3)cc1			785737	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2'- fluoro-6'-methoxy-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 241	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785737&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573252	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(C(=O)O)cc4F)cc2)OCCO3)c1			785738	(S)-4'-((2-(8-(((4- carbamimidoylthiophen- 2- yl)methyl)carbamoyl)- 1,4-dioxa-7- azaspiro[4.4]nonan-7- yl)-2- oxoethyl)carbamoyl)-2- fluoro-[1,1'-biphenyl]-4- carboxylic acid::US20250346585, Compound 242	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785738&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573253	CO[C@@H]1C[C@@H](C(=O)NCc2cc(NC(=O)CNC(=O)c3ccc(Oc4ccc(F)cc4)cc3)cs2)N(C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)C1			785739	(2S,4R)-N-((4-(2-(4-(4- fluorophenoxy)benzamido) acetamido)thiophen- 2-yl)methyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- methoxypyrrolidine-2- carboxamide::US20250346585, Compound 243	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785739&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573254	Nc1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785740	(S)-N-((4- aminothiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 244	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785740&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573255	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CN2CCc4cc(-c5ccc(F)cc5F)ccc4C2=O)OCCO3)c1			785741	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-(2-(6- (2,4-difluorophenyl)-1- oxo-3,4- dihydroisoquinolin- 2(1H)-yl)acetyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 245	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785741&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573256	N=C(N)c1csc([C@H](NC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)C(F)(F)F)c1			785742	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2,2,2- trifluoroethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 246	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785742&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573257	COC(=O)/N=C(/N)c1csc([C@@H](C)NC(=O)[C@@H]2C[C@@H](OC(F)F)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785743	(E)-methyl (amino(5- ((R)-1-((2S,4R)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 247	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785743&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573258	C[C@@H](NC(=O)[C@@H]1C[C@@H](Oc2ccccc2)CN1C(=O)CNC(=O)c1ccc2oc3ccccc3c2c1)c1cc(C(=N)N)cs1			785744	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- phenoxypyrrolidine-2- carboxamide::US20250346585, Compound 248	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785744&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573259	CCCCCCOC(=O)/N=C(/N)c1csc([C@@H](C)NC(=O)[C@@H]2C[C@](F)(COC)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785745	(E)-hexyl (amino(5- ((R)-1-((2S,4R)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 249	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785745&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573260	COC(=O)/N=C(/N)c1csc([C@@H](C)NC(=O)[C@@H]2C[C@](F)(CF)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785746	(E)-methyl (amino(5- ((R)-1-((2S,4R)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl) pyrrolidine-2- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 250	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785746&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573261	N=C(N)c1csc(CCNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)c1			785747	(S)-N-(2-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 251	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785747&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573262	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=N)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785748	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4-((S)- S- methylsulfonimidoyl) pyrrolidine-2- carboxamide::US20250346585, Compound 252	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785748&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573263	CCCCCCOC(=O)/N=C(/N)c1csc([C@@H](C)NC(=O)[C@@H]2C[C@](F)(CF)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785749	(E)-hexyl (amino(5- ((R)-1-((2S,4R)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl) pyrrolidine-2- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 253	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785749&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573264	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3sc4ccccc4c3c1)OCCO2)c1cc(C(=N)N)cs1			785750	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7- ((dibenzo[b,d]thiophene- 2-carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 254	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785750&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573265	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CN2CCc4cc(-c5ccc(F)cc5)ccc4C2=O)OCCO3)c1			785751	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-(2-(6-(4- fluorophenyl)-1-oxo- 3,4-dihydroisoquinolin- 2(1H)-yl)acetyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 255	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785751&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573266	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CN2CCc4cc(-c5ccccc5)ccc4C2=O)OCCO3)c1			785752	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-(2-(1- oxo-6-phenyl-3,4- dihydroisoquinolin- 2(1H)-yl)acetyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 256	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785752&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573267	Cc1ccc(-c2ccc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)NCc3cc(C(=N)N)cs3)OCCO4)cc2)c(C)c1			785753	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2',4'- dimethyl-[1,1'- biphenyl]-4- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 257	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785753&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573268	CCCCCCOC(=O)/N=C(/N)c1csc([C@@H](C)NC(=O)[C@@H]2C[C@@H](OC(F)F)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785754	(E)-hexyl (amino(5- ((R)-1-((2S,4R)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamido)ethyl) thiophen-3- yl)methylene)carbamate::US20250346585, Compound 258	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785754&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573269	C[C@@]12C[C@@H]1N(C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)[C@H](C(=O)Nc1cc(C(=N)N)cs1)C2			785755	(1S,3S,5S)-N-(4- carbamimidoylthiophen- 2-yl)-2-((9,9-difluoro- 9H-fluorene-3- carbonyl)glycyl)-5- methyl-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 259	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785755&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573270	C[C@@H](NC(=O)[C@@H]1C[C@](F)(Cn2ccnn2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785756	(2S,4R)-4-((1H-1,2,3- triazol-1-yl)methyl)-N- ((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoropyrrolidine-2- carboxamide::US20250346585, Compound 260	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785756&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573271	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1S3(=O)=O)OCCO2)c1cc(C(=N)N)cs1			785757	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((5,5- dioxidodibenzo[b,d] thiophene-2- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 261	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785757&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573272	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)C(F)(F)c1ccccc1-2)c1cc(C(=N)N)cs1			785758	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-2- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 262	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785758&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573273	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)C(F)(F)c1ccccc1-2)c1cc(C(=N)N)cs1			785759	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-2- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 263	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785759&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573274	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)C(F)(F)c2ccccc2-3)C1			785760	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-2- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 264	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785760&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573275	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)C(F)(F)c1ccccc1-2)c1cc(C(=N)N)cs1			785761	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-2- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 265	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785761&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573276	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccncc4F)cc2)OCCO3)c1			785762	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4-(3- fluoropyridin-4- yl)benzoyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 266	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785762&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573277	C[C@@H](NC(=O)[C@@H]1C[C@]2(CN3CCOCC3)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785763	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5- (morpholinomethyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 267	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785763&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573278	C[C@@H](NC(=O)[C@@H]1C[C@@](C)(F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785764	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- methylpyrrolidine-2- carboxamide::US20250346585, Compound 268	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785764&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573279	CC(=O)NCCNC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785765	(2S,4S)-4-(((2- acetamidoethyl)amino) methyl)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoropyrrolidine-2- carboxamide::US20250346585, Compound 269	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785765&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573280	C[C@@H](NC(=O)[C@@H]1CC(=C(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785766	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (difluoromethylene) pyrrolidine-2- carboxamide::US20250346585, Compound 270	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785766&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573281	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)Oc1ccccc1S3)OCCO2)c1cc(C(=N)N)cs1			785767	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7- ((phenoxathiine-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 271	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785767&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573282	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc(O)cc1)OCCO2)c1cc(C(=N)N)cs1			785768	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((4- hydroxybenzoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 272	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785768&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573283	N=C(N)c1csc(CNC(=O)C2CC3(CNC3)CN2C(=O)CNC(=O)CCCOc2ccccc2)c1			785769	N-((4- carbamimidoylthiophen- 2-yl)methyl)-6-((4- phenoxybutanoyl)glycyl)- 2,6- diazaspiro[3.4]octane- 7-carboxamide::US20250346585, Compound 273	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785769&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573284	C[C@@H](NC(=O)[C@@H]1C[C@]2(Cn3ccnn3)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785770	(1S,3S,5S)-5-((1H- 1,2,3-triazol-1- yl)methyl)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 274	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785770&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573285	N=C(N)c1csc([C@@H](NC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)C(F)(F)F)c1			785771	(S)-N-((S)-1-(4- carbamimidoylthiophen- 2-yl)-2,2,2- trifluoroethyl)-7-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 275	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785771&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573286	C[C@@H](NC(=O)[C@@H]1C[C@]2(C)C[C@@H]2N1C(=O)CNC(=O)c1ccc(Oc2ccccc2)cc1)c1cc(CC(=N)N)cs1			785772	(1S,3S,5S)-N-((R)-1-(4- (2-amino-2- iminoethyl)thiophen-2- yl)ethyl)-5-methyl-2-((4- phenoxybenzoyl)glycyl)- 2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 276	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785772&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573287	COC1c2ccccc2-c2cc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)ccc21			785773	(8S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((9- methoxy-9H-fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 277	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785773&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573288	CO[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3cc4ccccc4cc3c2)C1			785774	(2S,4R)-1- ((anthracene-2- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- methoxypyrrolidine-2- carboxamide::US20250346585, Compound 278	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785774&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573289	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)oc1ccccc13)OCCO2)c1cc(C(=N)N)cs1			785775	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7- ((dibenzo[b,d]furan-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 279	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785775&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573290	CC(C)S(=O)(=O)[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785776	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (isopropylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 280	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785776&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573291	C[C@@H](NC(=O)[C@@H]1C[C@]2(Cn3cncn3)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785777	(1S,3S,5S)-5-((1H- 1,2,4-triazol-1- yl)methyl)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 281	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785777&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573292	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(Nc3nccs3)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785778	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-((4-(thiazol-2- ylamino)thiophen-2- yl)methyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 282	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785778&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573293	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(Nc3ncc[nH]3)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785779	(S)-N-((4-((1H-imidazol- 2-yl)amino)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 283	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785779&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573294	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(NC3=NCCS3)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785780	(S)-N-((4-((4,5- dihydrothiazol-2- yl)amino)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 284	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785780&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573295	Nc1cccc(Nc2csc(CNC(=O)[C@@H]3CC4(CN3C(=O)CNC(=O)c3ccc(Oc5ccc(F)cc5)cc3)OCCO4)c2)n1			785781	(S)-N-((4-((6- aminopyridin-2- yl)amino)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 285	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785781&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573296	CS(=O)(=O)N(c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1)S(C)(=O)=O			785782	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-((4-((N- (methylsulfonyl)methyl) sulfonamido)thiophen- 2-yl)methyl)-1,4-dioxa- 7-azaspiro[4.4]nonane- 8-carboxamide::US20250346585, Compound 286	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785782&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573297	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CN2Cc4ccc(-c5ccc(F)cc5F)cc4C2)OCCO3)c1			785783	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-(2-(5- (2,4- difluorophenyl)isoindolin- 2-yl)acetyl)-1,4-dioxa- 7-azaspiro[4.4]nonane- 8-carboxamide::US20250346585, Compound 287	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785783&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573298	CC(=O)Nc1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785784	(S)-N-((4- acetamidothiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 288	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785784&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573299	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(N3CCCC3)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785785	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-((4-(pyrrolidin- 1-yl)thiophen-2- yl)methyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 289	Complement C1s subcomponent	Homo sapiens		 550							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785785&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573300	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(N3CCCC3=O)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785786	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-((4-(2- oxopyrrolidin-1- yl)thiophen-2- yl)methyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 290	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785786&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573301	C[C@H](NC(=O)c1ccc(-c2ccc(F)cc2F)cc1)C(=O)N1CC2(C[C@H]1C(=O)NCc1cc(C(=N)N)cs1)OCCO2			785787	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2',4'- difluoro-[1,1'-biphenyl]- 4-carbonyl)-L-alanyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 291	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785787&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573302	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CO)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785788	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoro-4- (hydroxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 292	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785788&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573303	C[C@@]12C[C@@H]1N(C(=O)CNC(=O)c1ccc(Oc3ccccc3)cc1)[C@H](C(=O)NCc1cc3c(s1)C(N)=NCC3)C2			785789	(1S,3S,5S)-N-((7- amino-4,5- dihydrothieno[2,3- c]pyridin-2-yl)methyl)-5- methyl-2-((4- phenoxybenzoyl)glycyl)- 2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 293	Complement C1s subcomponent	Homo sapiens		 550							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785789&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573304	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)Oc1ccccc1N3)OCCO2)c1cc(C(=N)N)cs1			785790	N-(2-((S)-8-(((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 1,4-dioxa-7- azaspiro[4.4]nonan-7- yl)-2-oxoethyl)-10H- phenoxazine-3- carboxamide::US20250346585, Compound 294	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785790&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573305	COC[C@@H]1C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3oc4ccccc4c3c2)C1			785791	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-2- carbonyl)glycyl)-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 295	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785791&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573306	C[C@H](NC(=O)c1ccc(-c2ccc(F)cc2)cc1)C(=O)N1CC2(C[C@H]1C(=O)NCc1cc(C(=N)N)cs1)OCCO2			785792	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((4'- fluoro-[1,1'-biphenyl]-4- carbonyl)-L-alanyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 296	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785792&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573307	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccccc4)o2)OCCO3)c1			785793	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((5- phenylfuran-2- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 297	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785793&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573308	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(F)cc4F)o2)OCCO3)c1			785794	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((5-(2,4- difluorophenyl)furan-2- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 298	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785794&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573309	N=C(N)c1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(-c4ccc(F)cc4)o2)OCCO3)c1			785795	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((5-(4- fluorophenyl)furan-2- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 299	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785795&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573310	C[C@H](NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)N1CC2(C[C@H]1C(=O)NCc1cc(C(=N)N)cs1)OCCO2			785796	(S)-7-(([1,1'-biphenyl]- 4-carbonyl)-L-alanyl)-N- ((4- carbamimidoylthiophen- 2-yl)methyl)-1,4-dioxa- 7-azaspiro[4.4]nonane- 8-carboxamide::US20250346585, Compound 300	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785796&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573311	C[C@@H](NC(=O)c1ccc(-c2ccc(F)cc2F)cc1)C(=O)N1CC2(C[C@H]1C(=O)NCc1cc(C(=N)N)cs1)OCCO2			785797	(S)-N-((4- carbamimidoylthiophen- 2-yl)methyl)-7-((2',4'- difluoro-[1,1'-biphenyl]- 4-carbonyl)-D-alanyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 301	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785797&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573312	C[C@@H](NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)N1CC2(C[C@H]1C(=O)NCc1cc(C(=N)N)cs1)OCCO2			785798	(S)-7-(([1,1'-biphenyl]- 4-carbonyl)-D-alanyl)- N-((4- carbamimidoylthiophen- 2-yl)methyl)-1,4-dioxa- 7-azaspiro[4.4]nonane- 8-carboxamide::US20250346585, Compound 302	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785798&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573313	C[C@@H](NC(=O)[C@@H]1C[C@]2(CN)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785799	(1S,3S,5S)-5- (aminomethyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 303	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785799&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573314	C[C@@H](NC(=O)[C@@H]1C[C@]2(CN(C)C)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785800	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5- ((dimethylamino)methyl)- 2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 304	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785800&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573315	C[C@@H](NC(=O)[C@@H]1C[C@@H](CO)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785801	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (hydroxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 305	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785801&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573316	C[C@@H](NC(=O)[C@@H]1C[C@H](CO)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785802	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (hydroxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 306	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785802&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573317	C[C@@H](NC(=O)[C@@H]1C[C@@H](C(F)(F)F)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			785805	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- (trifluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 307	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785805&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573318	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1cc(NCCO)cs1)OCCO2)c1ccc(Oc2ccc(F)cc2)cc1			785806	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-((4-((2- hydroxyethyl)amino) thiophen-2-yl)methyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 308	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785806&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573319	C=CC(=O)Nc1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785807	(S)-N-((4- acrylamidothiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 309	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785807&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573320	NC(=O)CCNc1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785808	(S)-N-((4-((3-amino-3- oxopropyl)amino) thiophen-2-yl) methyl)-7-((4- (4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 310	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785808&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573321	NCCC(=O)Nc1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785809	(S)-N-((4-(3- aminopropanamido) thiophen-2-yl) methyl)-7-((4- (4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 311	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785809&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573322	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)Sc1ccccc1O3)OCCO2)c1cc(C(=N)N)cs1			785810	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7- ((phenoxathiine-2- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 312	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785810&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573323	C[C@@H](NC(=O)[C@@H]1C[C@]2(COCCN)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785811	(1S,3S,5R)-5-((2- aminoethoxy)methyl)- N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 313	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785811&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573324	N=C(N)c1csc(C(CN)NC(=O)[C@@H]2C[C@@H](OC(F)F)CN2C(=O)CNC(=O)c2ccc(Oc3ccccc3)cc2)c1			785812	(2S,4R)-N-(2-amino-1- (4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((4- phenoxybenzoyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 314	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785812&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573325	CC(=O)NCCNC[C@@]12C[C@@H]1N(C(=O)CNC(=O)c1ccc3c(c1)-c1ccccc1C3(F)F)[C@H](C(=O)N[C@H](C)c1cc(C(=N)N)cs1)C2			785813	(1S,3S,5S)-5-(((2- acetamidoethyl)amino) methyl)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 315	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785813&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573326	NCC(=O)Nc1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785814	(S)-N-((4-(2- aminoacetamido) thiophen-2-yl) methyl)-7-((4- (4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 316	Complement C1s subcomponent	Homo sapiens		 550							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785814&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573327	NC(=O)Nc1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785815	(S)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-N-((4- ureidothiophen-2- yl)methyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 317	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785815&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573328	NCCCCNc1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785816	(S)-N-((4-((4- aminobutyl)amino) thiophen-2-yl) methyl)-7-((4- (4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 318	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785816&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573329	Nc1c(Nc2csc(CNC(=O)[C@@H]3CC4(CN3C(=O)CNC(=O)c3ccc(Oc5ccc(F)cc5)cc3)OCCO4)c2)c(=O)c1=O			785821	(S)-N-((4-((2-amino- 3,4-dioxocyclobut-1-en- 1-yl)amino)thiophen-2- yl)methyl)-7-((4-(4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 319	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785821&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573330	NCCCC(=O)Nc1csc(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc(Oc4ccc(F)cc4)cc2)OCCO3)c1			785825	(S)-N-((4-(4- aminobutanamido) thiophen-2-yl) methyl)-7-((4- (4- fluorophenoxy)benzoyl) glycyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 320	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785825&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573331	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)Cc1ccc(-c3ccc(F)cc3F)cc1)OCCO2)c1cc(C(=N)N)cs1			785826	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-(2-(2',4'- difluoro-[1,1'-biphenyl]- 4-yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 321	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785826&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573332	C[C@@H](NC(=O)[C@@H]1C[C@H](C(F)(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785828	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (trifluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 322	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785828&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573333	N=C(N)c1csc(CNC(=O)[C@@H]2C[C@H](C(F)(F)F)CN2C(=O)CNC(=O)c2ccc(Oc3ccc(F)cc3)cc2)c1			785833	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4- (trifluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 323	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785833&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573334	C[C@@H](NC(=O)[C@@H]1C[C@@H](C(F)(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785838	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (trifluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 324	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785838&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573335	Cc1c2ccccc2cc2cc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)OCCO4)ccc12			785839	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((10- methylanthracene-2- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 325	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785839&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573336	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2[nH]c3ccccc3c2c1)c1cc(C(=N)N)cs1			785840	N-(2-((2S,4R)-2-(((R)-1- (4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 4- (difluoromethoxy) pyrrolidin-1-yl)- 2-oxoethyl)- 9H-carbazole-3- carboxamide::US20250346585, Compound 326	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785840&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573337	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)Oc1ccccc1S2)c1cc(C(=N)N)cs1			785841	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)-1- ((phenoxathiine-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 327	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785841&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573338	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)Oc1ccccc1S2)c1cc(C(=N)N)cs1			785842	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1- ((phenoxathiine-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 328	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785842&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573339	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1cccc(-c2ccc(F)cc2)c1)c1cc(C(=N)N)cs1			785843	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-1- ((4'-fluoro-[1,1'- biphenyl]-3- carbonyl)glycyl)-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 329	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785843&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573340	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1cccc(-c2ccc(F)cc2)c1)c1cc(C(=N)N)cs1			785844	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1- ((4'-fluoro-[1,1'- biphenyl]-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 330	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785844&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573341	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3cc4ccccc4nc3c1)OCCO2)c1cc(C(=N)N)cs1			785845	(S)-7-((acridine-3- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 331	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785845&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573342	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2sc3ccccc3c2c1)c1cc(C(=N)N)cs1			785846	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]thiophene- 2-carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 332	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785846&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573343	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)Oc1ccccc1S2)c1cc(C(=N)N)cs1			785847	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (methylsulfonyl)-1- ((phenoxathiine-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 333	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785847&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573344	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1cccc(-c2ccc(F)cc2)c1)c1cc(C(=N)N)cs1			785852	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4'-fluoro- [1,1'-biphenyl]-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 334	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785852&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573345	Cc1ccc(-c2cccc(C(=O)NCC(=O)N3C[C@H](S(C)(=O)=O)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)c2)cc1			785853	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4'- methyl-[1,1'-biphenyl]- 3-carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 335	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785853&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573346	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1S2(=O)=O)c1cc(C(=N)N)cs1			785865	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((5,5- dioxidodibenzo[b,d] thiophene-2- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 336	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785865&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573347	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1S2(=O)=O)c1cc(C(=N)N)cs1			785866	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1- ((5,5- dioxidodibenzo[b,d] thiophene-2- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 337	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785866&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573348	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)Cc1ccc(-c3ccccc3)cc1)OCCO2)c1cc(C(=N)N)cs1			785867	(S)-7-(2-([1,1'- biphenyl]-4-yl)acetyl)- N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 338	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785867&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573349	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ncc(-c2ccccc2)cc1F)c1cc(C(=N)N)cs1			785868	N-(2-((2,4R)-2-(((R)-1- (4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 4- (methylsulfonyl) pyrrolidin-1-yl)- 2-oxoethyl)-3- fluoro-5- phenylpicolinamide::US20250346585, Compound 339	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785868&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573350	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2[nH]c3ccccc3c2c1)c1cc(C(=N)N)cs1			785869	N-(2-((2S,4R)-2-(((R)-1- (4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 4- (methylsulfonyl) pyrrolidin-1-yl)- 2-oxoethyl)-9H- carbazole-3- carboxamide::US20250346585, Compound 340	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785869&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573351	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2[nH]c3ccccc3c2c1)c1cc(C(=N)N)cs1			785870	N-(2-((2S,4R)-2-(((R)-1- (4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 4-fluoro-4- (fluoromethyl)pyrrolidin- 1-yl)-2-oxoethyl)-9H- carbazole-3- carboxamide::US20250346585, Compound 341	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785870&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573352	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1S2(=O)=O)c1cc(C(=N)N)cs1			785874	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((5,5- dioxidodibenzo[b,d] thiophene-2- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 342	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785874&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573353	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)sc2ccccc23)C1			785876	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]thiophene- 3-carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 343	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785876&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573354	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)C(C)(C)c2ccccc2-3)C1			785877	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- dimethyl-9H-fluorene-2- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 344	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785877&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573355	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CCC(=O)c1ccc(-c3ccccc3)cc1)OCCO2)c1cc(C(=N)N)cs1			785882	(S)-7-(4-([1,1'- biphenyl]-4-yl)-4- oxobutanoyl)-N-((R)-1- (4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 345	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785882&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573356	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CN1Cc3ccc(-c4ccc(F)cc4F)cc3C1=O)OCCO2)c1cc(C(=N)N)cs1			785884	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-(2-(6-(2,4- difluorophenyl)-1- oxoisoindolin-2- yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 346	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785884&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573357	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ncc(-c3ccccc3)cc1F)OCCO2)c1cc(C(=N)N)cs1			785893	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((3-fluoro- 5- phenylpicolinoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 347	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785893&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573358	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)C(C)(C)c1ccccc1-2)c1cc(C(=N)N)cs1			785894	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1- ((9,9-dimethyl-9H- fluorene-2- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 348	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785894&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573359	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)sc1ccccc12)c1cc(C(=N)N)cs1			785895	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]thiophene- 3-carbonyl)glycyl)-4- fluoro-4- (fluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 349	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785895&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573360	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)S(=O)(=O)c2ccccc2-3)C1			785896	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((5,5- dioxidodibenzo[b,d] thiophene-3- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 350	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785896&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573361	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)C2CC2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785897	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (cyclopropylsulfonyl)-1- ((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 351	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785897&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573362	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)sc1ccccc12)c1cc(C(=N)N)cs1			785898	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]thiophene- 3-carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 352	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785898&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573363	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2sc3ccccc3c2c1)c1cc(C(=N)N)cs1			785900	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]thiophene- 2-carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 353	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785900&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573364	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2sc3ccccc3c2c1)c1cc(C(=N)N)cs1			785901	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]thiophene- 2-carbonyl)glycyl)-4- fluoro-4- (fluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 354	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785901&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573365	*C1(F)c2ccccc2-c2cc(C(=O)NCC(=O)N3C[C@@H](c4cccnc4)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)ccc21			785902	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (pyridin-3-yl)pyrrolidine- 2-carboxamide::US20250346585, Compound 355	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785902&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573366	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ncc(-c3ccc(F)cc3F)cc1F)OCCO2)c1cc(C(=N)N)cs1			785903	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((5-(2,4- difluorophenyl)-3- fluoropicolinoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 356	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785903&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573367	CC1c2ccccc2-c2ccc(C(=O)NCC(=O)N3C[C@H](OC(F)F)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)cc21			785913	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((9- methyl-9H-fluorene-2- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 357	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785913&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573368	C[C@@H](NC(=O)[C@@H]1C[C@H](c2ccccn2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785914	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (pyridin-2-yl)pyrrolidine- 2-carboxamide::US20250346585, Compound 358	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785914&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573369	C[C@@H](NC(=O)[C@H]1CN(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)[C@@](F)(Cn2ccnc2)C1)c1cc(C(=N)N)cs1			785917	(2S,4S)-4-((1H- imidazol-1-yl)methyl)- N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- fluoropyrrolidine-2- carboxamide::US20250346585, Compound 359	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785917&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573370	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)oc2ccccc23)C1			785925	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-3- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 360	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785925&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573371	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)oc1ccccc12)c1cc(C(=N)N)cs1			785926	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-3- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 361	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785926&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573372	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CNC(=O)c1ccc2c(c1)S(=O)(=O)c1ccccc1-2)c1cc(C(=N)N)cs1			785927	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1- ((5,5- dioxidodibenzo[b,d] thiophene-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 362	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785927&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573373	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)C(C)c2ccccc2-3)C1			785928	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (methoxymethyl)-1-((9- methyl-9H-fluorene-2- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 363	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785928&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573374	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2cccc(-c3ccc(F)cc3)c2)C1			785929	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-1- ((4'-fluoro-[1,1'- biphenyl]-3- carbonyl)glycyl)-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 364	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785929&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573375	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CN1Cc3cc(-c4ccccc4)ccc3C1=O)OCCO2)c1cc(C(=N)N)cs1			785932	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-(2-(1-oxo- 5-phenylisoindolin-2- yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 365	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785932&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573376	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CN1Cc3cc(-c4ccc(F)cc4F)ccc3C1=O)OCCO2)c1cc(C(=N)N)cs1			785942	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-(2-(5-(2,4- difluorophenyl)-1- oxoisoindolin-2- yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 366	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785942&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573377	C[C@@H](NC(=O)[C@@H]1C[C@]2(COCCN(C)C)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785945	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5-((2- (dimethylamino)ethoxy) methyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 367	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785945&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573378	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)C(C)(C)c1ccccc1-2)c1cc(C(=N)N)cs1			785953	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- dimethyl-9H-fluorene-2- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 368	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785953&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573379	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)C(C)(C)c1ccccc1-2)c1cc(C(=N)N)cs1			785954	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- dimethyl-9H-fluorene-2- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 369	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785954&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573380	C[C@@H](NC(=O)[C@@H]1C[C@H](c2ccncc2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785957	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (pyridin-4-yl)pyrrolidine- 2-carboxamide::US20250346585, Compound 370	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785957&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573381	CC1c2ccccc2-c2ccc(C(=O)NCC(=O)N3C[C@@](F)(CF)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)cc21			785958	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)-1-((9- methyl-9H-fluorene-2- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 371	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785958&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573382	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)oc1ccccc12)c1cc(C(=N)N)cs1			785959	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 372	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785959&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573383	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)Oc2ccccc2S3)C1			785960	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (methoxymethyl)-1- ((phenoxathiine-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 373	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785960&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573384	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3c(c1)[nH]c1ccccc13)OCCO2)c1cc(C(=N)N)cs1			785961	(S)-7-((9H-carbazole-2- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 374	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785961&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573385	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)S(=O)(=O)c1ccccc1-2)c1cc(C(=N)N)cs1			785962	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((5,5- dioxidodibenzo[b,d] thiophene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl)pyrrolidine- 2-carboxamide::US20250346585, Compound 375	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785962&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573386	N=C(N)c1csc([C@@H](CO)NC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)c1			785963	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 7-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 376	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785963&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573387	C[C@@H](NC(=O)[C@@H]1C[C@@H](c2ccncc2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			785964	(2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (pyridin-4-yl)pyrrolidine- 2-carboxamide::US20250346585, Compound 377	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785964&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573388	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)sc1ccccc12)c1cc(C(=N)N)cs1			785965	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]thiophene- 3-carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 378	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785965&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573389	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)oc1ccccc12)c1cc(C(=N)N)cs1			785966	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]furan-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 379	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785966&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573390	CC1(C)c2ccccc2-c2cc(C(=O)NCC(=O)N3C[C@H](S(C)(=O)=O)C[C@H]3C(=O)N[C@H](CO)c3cc(C(=N)N)cs3)ccc21			785967	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-dimethyl-9H- fluorene-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 380	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785967&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573391	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)S(=O)(=O)c1ccccc1-2)c1cc(C(=N)N)cs1			785968	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((5,5- dioxidodibenzo[b,d] thiophene-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 381	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785968&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573392	N=C(N)c1csc([C@@H](CO)NC(=O)[C@@H]2C[C@]3(COCCCN)C[C@@H]3N2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785969	(1S,3S,5R)-5-((3- aminopropoxy)methyl)- N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 382	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785969&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573393	CS(=O)(=O)[C@@H]1C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ncc(-c3ccccc3)cc2F)C1			785970	N-(2-((2S,4R)-2-(((R)-1- (4- carbamimidoylthiophen- 2-yl)-2- hydroxyethyl)carbamoyl)- 4- (methylsulfonyl) pyrrolidin-1-yl)- 2-oxoethyl)-3- fluoro-5- phenylpicolinamide::US20250346585, Compound 383	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785970&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573394	O=C(NCC(=O)N1CC2(C[C@H]1C(=O)NCc1ccn[nH]1)OCCO2)c1ccc(Oc2ccccc2)cc1			785971	(S)-N-((1H-pyrazol-5- yl)methyl)-7-((4- phenoxybenzoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 384	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785971&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573395	C[C@@H](NC(=O)[C@@H]1C[C@@H](OC(F)F)CN1C(=O)CN1Cc2cc(-c3ccccc3)ccc2C1=O)c1cc(C(=N)N)cs1			785972	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-(2- (1-oxo-5- phenylisoindolin-2- yl)acetyl)pyrrolidine-2- carboxamide::US20250346585, Compound 385	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785972&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573396	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CN1Cc3ccc(-c4ccccc4)cc3C1=O)OCCO2)c1cc(C(=N)N)cs1			785973	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-(2-(1-oxo- 6-phenylisoindolin-2- yl)acetyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 386	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785973&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573397	C[C@@]12C[C@@H]1N(C(=O)CNC(=O)c1ccc(Oc3ccccc3)cc1)[C@H](C(=O)NCc1cccc(Cl)c1Cl)C2			785974	(1S,3S,5S)-N-(2,3- dichlorobenzyl)-5- methyl-2-((4- phenoxybenzoyl)glycyl)- 2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 387	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785974&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573398	Cc1ccc(-c2cnc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N(N)[C@H](C)c3cc(C(=N)N)cs3)OCCO4)c(F)c2)cc1			785975	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-7-((3-fluoro- 5-(p- tolyl)picolinoyl)glycyl)- 1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 388	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785975&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573399	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3[nH]c4ccccc4c3c2)C1			785976	N-(2-((2S,4R)-2-(((R)-1- (4- carbamimidoylthiophen- 2-yl)ethyl)carbamoyl)- 4-fluoro-4- (methoxymethyl) pyrrolidin-1-yl)- 2-oxoethyl)- 9H-carbazole-3- carboxamide::US20250346585, Compound 389	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785976&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573400	CC1c2ccccc2-c2ccc(C(=O)NCC(=O)N3C[C@H](S(C)(=O)=O)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)cc21			785979	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9- methyl-9H-fluorene-2- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 390	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785979&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573401	C[C@@H](NC(=O)[C@@H]1CC2(CN1C(=O)CNC(=O)c1ccc3nc4ccccc4cc3c1)OCCO2)c1cc(C(=N)N)cs1			785980	(S)-7-((acridine-2- carbonyl)glycyl)-N-((R)- 1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1,4-dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 391	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785980&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573402	C[C@@H](NC(=O)[C@@H]1C[C@@H](S(C)(=O)=O)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2OC(F)F)c1cc(C(=N)N)cs1			785983	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9- (difluoromethoxy)-9H- fluorene-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 392	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785983&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573403	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2S3(=O)=O)C1			785984	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((5,5- dioxidodibenzo[b,d] thiophene-2- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 393	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785984&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573404	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3sc4ccccc4c3c2)C1			785985	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1- ((dibenzo[b,d]thiophene- 2-carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 394	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785985&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573405	CO[C@@H]1C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(C)C)C1			785986	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-dimethyl-9H- fluorene-3- carbonyl)glycyl)-4- methoxypyrrolidine-2- carboxamide::US20250346585, Compound 395	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785986&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573406	N=C(N)c1csc([C@@H](CO)NC(=O)[C@@H]2C[C@@H](OC(F)F)CN2C(=O)CNC(=O)c2ccc3c(c2)C(F)(F)c2ccccc2-3)c1			785987	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-2- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 396	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785987&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573407	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)C(F)(F)c2ccccc2-3)C1			785988	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-2- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 397	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785988&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573408	N=C(N)c1csc([C@@H](CO)NC(=O)[C@@H]2C[C@](F)(CF)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785989	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 398	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785989&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573409	CC1(C)c2ccccc2-c2cc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](CO)c3cc(C(=N)N)cs3)OCCO4)ccc21			785990	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 7-((9,9-dimethyl-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 399	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785990&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573410	CS(=O)(=O)[C@@H]1C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			785991	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 400	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785991&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573411	CC1(C)c2ccccc2-c2cc(C(=O)NCC(=O)N3C[C@@](F)(CF)C[C@H]3C(=O)N[C@H](CO)c3cc(C(=N)N)cs3)ccc21			785992	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-dimethyl-9H- fluorene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 401	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785992&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573412	CS(=O)(=O)[C@@H]1C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2cccc(-c3ccc(F)cc3)c2)C1			785993	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((4'-fluoro-[1,1'- biphenyl]-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 402	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785993&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573413	N=C(N)c1csc([C@@H](CO)NC(=O)[C@@H]2C[C@@H](OC(F)F)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1			785995	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-4- (difluoromethoxy) pyrrolidine-2- carboxamide::US20250346585, Compound 403	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785995&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573414	Cc1ccc(-c2cccc(C(=O)NCC(=O)N3C[C@H](S(C)(=O)=O)C[C@H]3C(=O)N[C@H](CO)c3cc(C(=N)N)cs3)c2)cc1			785996	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((4'-methyl-[1,1'- biphenyl]-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 404	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785996&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573415	N=C(N)c1csc([C@@H](CO)NC(=O)[C@@H]2C[C@](F)(CF)CN2C(=O)CNC(=O)c2ccc3c(c2)C(F)(F)c2ccccc2-3)c1			785997	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-2- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 405	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785997&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573416	CS(=O)(=O)[C@@H]1C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)C(F)(F)c2ccccc2-3)C1			785999	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-2- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 406	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=785999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=785999&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573417	CO[C@@H]1C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			786000	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-4- methoxypyrrolidine-2- carboxamide::US20250346585, Compound 407	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786000&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573418	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)C1			786001	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 408	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786001&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573419	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(C)C)C1			786002	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-dimethyl-9H- fluorene-3- carbonyl)glycyl)-4- fluoro-4- (methoxymethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 409	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786002&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573420	C[C@@H](NC(=O)[C@H]1C[C@]2(CC(F)(F)F)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			786003	(1S,3R,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5- (2,2,2-trifluoroethyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 410	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786003&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573421	C[C@@H](NC(=O)[C@@H]1C[C@]2(CC(F)(F)F)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			786004	(1S,3S,5S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5- (2,2,2-trifluoroethyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 411	Complement C1s subcomponent	Homo sapiens		>1000							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786004&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573422	C[C@@H](NC(=O)[C@@H]1C[C@@H](c2nccs2)CN1C(=O)CNC(=O)c1ccc(Oc2ccc(F)cc2)cc1)c1cc(C(=N)N)cs1			786005	(2S,4R)-N-(R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((4-(4- fluorophenoxy)benzoyl) glycyl)-4-(thiazol-2- yl)pyrrolidine-2- carboxamide::US20250346585, Compound 412	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786005&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573423	CC(F)O[C@@H]1C[C@@H](C(=O)N[C@H](CO)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(C)C)C1			786006	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 4-(difluoromethoxy)-1- ((9,9-dimethyl-9H- fluorene-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 413	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786006&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573424	C[C@@H](NC(=O)[C@@H]1C[C@]2(COCCCCN)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			786007	(1S,3S,5R)-5-((4- aminobutoxy)methyl)- N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 414	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786007&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573425	C[C@@H](NC(=O)[C@@H]1C[C@]2(COCCCCN(C)C)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			786008	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5-((4- (dimethylamino)butoxy) methyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 415	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786008&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573426	C[C@@H](NC(=O)[C@@H]1CC(c2ncco2)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			786009	(S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-4- (oxazol-2-yl)pyrrolidine- 2-carboxamide::US20250346585, Compound 416	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786009&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573427	C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(C)C)c1cc(C(=N)N)cs1			786010	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)-1-((9- methyl-9H-fluorene-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 417	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786010&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573428	COC[C@@]1(F)C[C@@H](C(=O)N[C@H](C)c2cc(C(=N)N)cs2)N(C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3C)C1			786011	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (methoxymethyl)-1-((9- methyl-9H-fluorene-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 418	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786011&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573429	CC1c2ccccc2-c2cc(C(=O)NCC(=O)N3C[C@H](S(C)(=O)=O)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)ccc21			786012	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-1-((9- methyl-9H-fluorene-3- carbonyl)glycyl)-4- (methylsulfonyl) pyrrolidine-2- carboxamide::US20250346585, Compound 419	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786012&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573430	C[C@@H](NC(=O)[C@@H]1C[C@]2(Cc3ncno3)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			786013	(1S,3S,5S)-5-((1,2,4- oxadiazol-5-yl)methyl)- N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 420	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786013&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573431	CC1c2ccccc2-c2cc(C(=O)NCC(=O)N3C[C@H](OC(F)F)C[C@H]3C(=O)N[C@H](C)c3cc(C(=N)N)cs3)ccc21			786014	(2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4- (difluoromethoxy)-1-((9- methyl-9H-fluorene-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 421	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786014&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573432	C[C@@H](NC(=O)[C@@H]1C[C@]2(COCCCN(C)C)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1			786015	(1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5-((3- (dimethylamino) propoxy)methyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 422	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786015&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573433	N=C(N)c1c[nH]c(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)c1			786017	(S)-N-((4- carbamimidoyl-1H- pyrrol-2-yl)methyl)-7- ((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 423	Complement C1s subcomponent	Homo sapiens		<100							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5363&target=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786017&enzyme=Complement+C1s+subcomponent&column=ki&startPg=0&Increment=50&submit=Search											1	MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED	8TYP,6F1C,9X1H,6F1H,4LOR,4LMF,5UBM,8W18,4LOT,4LOS,1NZI	Complement C1s subcomponent	C1S_HUMAN	P09871	D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14