BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
1573755	CC(C)(C)S(=O)(=O)c1ccc2ncc(-c3cc(F)nc(F)c3)n2c1			786284	US20250346593, Example 1	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786284	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786284&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573756	COc1cc2ncc(-c3cc(N)c(OC)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786285	US20250346593, Example 2	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786285&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573757	COc1cc2ncc(-c3cc(F)c(C#N)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786286	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,6- difluorobenzonitrile::US20250346593, Example 3	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786286	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786286&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573758	COc1cc2ncc(-c3cn[nH]c3)n2cc1S(=O)(=O)C(C)(C)C			786287	6-(tert-butylsulfonyl)- 7-methoxy-3-(1H- pyrazol-4- yl)imidazo[1,2- a]pyridine::US20250346593, Example 4	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786287	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786287&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573759	COc1cc2ncc(-c3ccnc(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786288	6-(tert-butylsulfonyl)- 3-(2-fluoropyridin-4- yl)-7- methoxyimidazo[1,2- a]pyridine::US20250346593, Example 5	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786288	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786288&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573760	COc1cc2ncc(-c3cc(N)nc(C(F)(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786289	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- (trifluoromethyl) pyridin-2-amine::US20250346593, Example 6	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786289&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573761	COc1cc2ncc(-c3cc(N)c(=O)n(C)c3)n2cc1S(=O)(=O)C(C)(C)C			786290	3-amino-5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-1- methylpyridin-2(1H)- one::US20250346593, Example 7	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786290	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786290&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573762	COc1cc2ncc(-c3cc(Cl)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C			786291	6-(tert-butylsulfonyl)- 3-(2,6-dichloropyridin- 4-yl)-7- methoxyimidazo[1,2- a]pyridine::US20250346593, Example 8	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786291	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786291&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573763	COc1cc2ncc(-c3ccc(F)nc3F)n2cc1S(=O)(=O)C(C)(C)C			786292	6-(tert-butylsulfonyl)- 3-(2,6-difluoropyridin- 3-yl)-7- methoxyimidazo[1,2- a]pyridine::US20250346593, Example 9	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786292	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786292&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573764	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(OC)c1OC			786293	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,3- dimethoxyphenyl) propane-1-sulfonamide::US20250346593, Example 10	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786293	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786293&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573765	COc1cc2ncc(-c3ccnc(N)c3)n2cc1S(=O)(=O)C(C)(C)C	InChI=1S/C17H20N4O3S/c1-17(2,3)25(22,23)14-10-21-12(11-5-6-19-15(18)7-11)9-20-16(21)8-13(14)24-4/h5-10H,1-4H3,(H2,18,19)	XAKWGUFILBMXGB-UHFFFAOYSA-N	50279314	CHEMBL4173646::US20250346593, Example 11	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279314&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search			145951857	406793704							1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573766	COc1cc2ncc(-c3cc(C)nc(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786295	2-fluoro-4-[7-methoxy- 6-(2-methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-6- methylpyridine::US20250346593, Example 12	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786295	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786295&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573767	COc1cc2ncc(-c3cc(F)nc([N+](=O)[O-])c3)n2cc1S(=O)(=O)C(C)(C)C			786296	3-(3-fluoro-5- nitrophenyl)-7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridine::US20250346593, Example 13	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786296&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573768	COc1cc2ncc(-c3ccc(N)nc3F)n2cc1S(=O)(=O)C(C)(C)C			786297	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2-amine::US20250346593, Example 14	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786297&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573769	COc1cc2ncc(-c3ccc(N)nc3)n2cc1S(=O)(=O)C(C)(C)C			786298	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)pyridin- 2-amine::US20250346593, Example 15	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786298&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573770	COc1cc2ncc(-c3ccc(N(C)C)nc3)n2cc1S(=O)(=O)C(C)(C)C			786299	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-N,N- dimethylpyridin-2- amine::US20250346593, Example 16	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786299&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573771	COc1cc2ncc(-c3cnc(N)c(OC)c3)n2cc1S(=O)(=O)C(C)(C)C			786300	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- methoxypyridin-2- amine::US20250346593, Example 17	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786300&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573772	COc1cc2ncc(-c3ccc(N)cc3)n2cc1S(=O)(=O)C(C)(C)C			786301	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)aniline::US20250346593, Example 18	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786301&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573773	COc1cc2ncc(-c3cnc(N)c(C(F)(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786302	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- (trifluoromethyl)pyridin- 2-amine::US20250346593, Example 19	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786302&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573774	COc1cc2ncc(-c3ccc(N)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786303	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluoroaniline::US20250346593, Example 20	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786303&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573775	COc1cc2ncc(-c3cnc(N)cc3F)n2cc1S(=O)(=O)C(C)(C)C			786304	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-4- fluoropyridin-2-amine::US20250346593, Example 21	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786304	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786304&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573776	COc1cc2ncc(-c3cnc(N)c(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C			786305	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- chloropyridin-2-amine::US20250346593, Example 22	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786305&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573777	COc1cc2ncc(-c3cnc(N)c(C#N)c3)n2cc1S(=O)(=O)C(C)(C)C			786306	2-amino-5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)nicotinonitrile::US20250346593, Example 23	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786306&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573778	COc1cc(N)cc(-c2cnn3ccc(S(=O)(=O)C(C)(C)C)cc23)c1			786307	3-(5-(tert- butylsulfonyl)pyrazolo [1,5-a]pyridin-3-yl)-5- methoxyaniline::US20250346593, Example 24	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786307&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573779	COc1ccc(-c2cnn3ccc(S(=O)(=O)C(C)(C)C)cc23)cc1N			786308	5-(5-(tert- butylsulfonyl)pyrazolo [1,5-a]pyridin-3-yl)-2- methoxyaniline::US20250346593, Example 25	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786308&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573780	CC(C)(C)S(=O)(=O)c1ccn2ncc(-c3ccc(N)nc3)c2c1			786309	5-(5-(tert- butylsulfonyl)pyrazolo [1,5-a]pyridin-3- yl)pyridin-2-amine::US20250346593, Example 26	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786309&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573781	COc1cc2ncc(-c3ccc(F)c(N)c3F)n2cc1S(=O)(=O)C(C)(C)C			786310	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,6- difluoroaniline::US20250346593, Example 27	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786310&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573782	COc1cc2ncc(-c3ccc(OC)c(N)c3F)n2cc1S(=O)(=O)C(C)(C)C			786311	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluoro-6- methoxyaniline::US20250346593, Example 28	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786311&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573783	COc1cc2ncc(-c3cccc(N)c3F)n2cc1S(=O)(=O)C(C)(C)C			786312	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluoroaniline::US20250346593, Example 29	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786312&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573784	COc1cc2ncc(-c3cncc(N)c3)n2cc1S(=O)(=O)C(C)(C)C			786313	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)pyridin- 3-amine::US20250346593, Example 30	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786313&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573785	COc1cc2ncc(-c3cnc(N)c(N)c3)n2cc1S(=O)(=O)C(C)(C)C			786314	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)pyridine-2,3-diamine::US20250346593, Example 31	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786314&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573786	COc1cc2ncc(-c3cc(N)ccc3F)n2cc1S(=O)(=O)C(C)(C)C			786315	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-4- fluoroaniline::US20250346593, Example 32	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786315&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573787	COc1ccc(-c2cnc3cc(OC)c(S(=O)(=O)C4CC4)cn23)cc1N			786316	5-(6- (cyclopropylsulfonyl)- 7-methoxyimidazo[1,2- a]pyridin-3-yl)-2- methoxyaniline::US20250346593, Example 33	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786316&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573788	CNc1cncc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786317	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-N- methylpyridin-3-amine::US20250346593, Example 34	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786317&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573789	COc1cc2ncc(-c3cc(N)c(C)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786318	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoro-2-methylaniline::US20250346593, Example 35	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786318&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573790	COc1cc2ncc(-c3cccc(N)c3)n2cc1S(=O)(=O)C(C)(C)C			786319	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)aniline::US20250346593, Example 36	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786319&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573791	COc1cc2ncc(-c3cc(N)cc(S(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786320	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- (methylsulfonyl)aniline::US20250346593, Example 37	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786320&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573792	COc1cc2ncc(-c3cc(F)cc(N)c3F)n2cc1S(=O)(=O)C(C)(C)C			786321	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,5- difluoroaniline::US20250346593, Example 38	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786321&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573793	COc1cc2ncc(-c3ccc(OC(F)F)c(N)c3)n2cc1S(=O)(=O)C(C)(C)C			786322	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- (difluoromethoxy)aniline::US20250346593, Example 39	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786322&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573794	COc1cc2ncc(-c3cc(F)c(N)c(N)c3F)n2cc1S(=O)(=O)C(C)(C)C			786323	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3,6- difluorobenzene-1,2- diamine::US20250346593, Example 40	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786323&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573795	COc1cc2ncc(-c3cc(N)cc(C#N)c3)n2cc1S(=O)(=O)C(C)(C)C			786324	3-amino-5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)benzonitrile::US20250346593, Example 41	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786324&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573796	COc1cc2ncc(-c3cc(N)cc(OC(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786325	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- (difluoromethoxy)aniline::US20250346593, Example 42	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786325&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573797	COc1cc2ncc(-c3cc(N)c(F)c(OC)c3)n2cc1S(=O)(=O)C(C)(C)C			786326	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluoro-3- methoxyaniline::US20250346593, Example 43	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786326&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573798	COc1cc2ncc(-c3cc(N)c(F)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786327	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,3- difluoroaniline::US20250346593, Example 44	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786327&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573799	COc1ccn2c(-c3cc(F)nc(F)c3)cnc2c1			786328	3-(2,6-difluoropyridin- 4-yl)-7- methoxyimidazo[1,2- a]pyridine::US20250346593, Example 45	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786328&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573800	COc1cc(N)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786329	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- methoxyaniline::US20250346593, Example 46	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786329&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573801	COc1cc2ncc(-c3cc(N)c(OC)c(OC)c3)n2cc1S(=O)(=O)C(C)(C)C			786330	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,3- dimethoxyaniline::US20250346593, Example 47	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786330&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573802	COc1cc2ncc(-c3cc(C)c(F)c(N)c3)n2cc1S(=O)(=O)C(C)(C)C			786331	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluoro-3-methylaniline::US20250346593, Example 48	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786331&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573803	COCc1cc(N)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786332	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- (methoxymethyl)aniline::US20250346593, Example 49	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786332&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573804	COc1cc2ncc(-c3cnc(OC(F)F)c(N)c3)n2cc1S(=O)(=O)C(C)(C)C			786333	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2-a] pyridin-3-yl)-2- (difluoromethoxy)pyridin- 3-amine::US20250346593, Example 50	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786333&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573805	COc1cc2ncc(-c3cc(N)c(OC)c(C#N)c3)n2cc1S(=O)(=O)C(C)(C)C			786334	3-amino-5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- methoxybenzonitrile::US20250346593, Example 51	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786334&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573806	COc1cc2ncc(-c3cc(F)c(OC)c(N)c3F)n2cc1S(=O)(=O)C(C)(C)C			786335	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,5- difluoro-6- methoxyaniline::US20250346593, Example 52	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786335&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573807	COc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(N)n1			786336	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- methoxypyridin-2- amine::US20250346593, Example 53	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786336&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573808	COc1cc2ncc(-c3cnc(OC)c(N)c3)n2cc1S(=O)(=O)C(C)(C)C			786337	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- methoxypyridin-3- amine::US20250346593, Example 54	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786337&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573809	COc1cc2ncc(-c3cc(C)c(OC)c(Cl)n3)n2cc1S(=O)(=O)C(C)(C)C			786338	6-(tert-butylsulfonyl)- 3-(6-chloro-5-methoxy- 4-methylpyridin-2-yl)- 7-methoxyimidazo[1,2- a]pyridine::US20250346593, Example 55	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786338&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573810	N#Cc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(F)c1OC			786339	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoro-2- methoxybenzonitrile::US20250346593, Example 56	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786339&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573811	COc1cc2ncc(-c3cc(F)c(OC)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786340	6-(tert-butylsulfonyl)- 3-(3,5-difluoro-4- methoxyphenyl)-7- methoxyimidazo[1,2- a]pyridine::US20250346593, Example 57	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786340&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573812	COc1cc2ncc(-c3cc(F)c(OC)c(OC)c3)n2cc1S(=O)(=O)C(C)(C)C			786341	6-(tert-butylsulfonyl)- 3-(3-fluoro-4,5- dimethoxyphenyl)-7- methoxyimidazo[1,2- a]pyridine::US20250346593, Example 58	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786341&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573813	COc1cc2ncc(-c3cc(F)c(OC)c(CCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786342	2-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoro-2- methoxyphenyl)ethan- 1-ol::US20250346593, Example 59	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786342&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573814	COc1cc2ncc(-c3csnc3OC)n2cc1S(=O)(=O)C(C)(C)C			786343	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- methoxyisothiazole::US20250346593, Example 60	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786343&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573815	COc1cc2ncc(-c3cc(F)cc(F)n3)n2cc1S(=O)(=O)C(C)(C)C			786344	6-(tert-butylsulfonyl)- 3-(4,6-difluoropyridin- 2-yl)-7- methoxyimidazo[1,2- a]pyridine::US20250346593, Example 61	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786344&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573816	CCOc1ncc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)s1			786345	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- ethoxythiazole::US20250346593, Example 62	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786345&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573817	COc1ccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc1F			786346	6-(tert-butylsulfonyl)- 3-(3-fluoro-4- methoxyphenyl)-7- methoxyimidazo[1,2- a]pyridine::US20250346593, Example 63	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786346&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573818	COc1cc2ncc(-c3cc(N)c(OCCO)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786347	2-(2-amino-4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluorophenoxy)ethan-1- ol::US20250346593, Example 64	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786347&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573819	COc1cc2ncc(-c3cc(N)c(OC(F)F)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786348	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- (difluoromethoxy)-3- fluoroaniline::US20250346593, Example 65	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786348&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573820	CCOc1c(N)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc1F			786349	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- ethoxy-3-fluoroaniline::US20250346593, Example 66	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786349&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573821	COc1cc2ncc(-c3ccc(N4CCCC4=O)nc3)n2cc1S(=O)(=O)C(C)(C)C			786350	1-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)pyridin- 2-yl)pyrrolidin-2-one::US20250346593, Example 67	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786350&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573822	COc1cc2ncc(-c3cnc(N)c(C)c3)n2cc1S(=O)(=O)C(C)(C)C			786351	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- methylpyridin-2-amine::US20250346593, Example 68	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786351&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573823	CNc1ccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cn1			786352	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-N- methylpyridin-2-amine::US20250346593, Example 69	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786352&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573824	COc1cc2ncc(-c3ccc(N)c(C#N)c3)n2cc1S(=O)(=O)C(C)(C)C			786353	2-amino-5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)benzonitrile::US20250346593, Example 70	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786353&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573825	COc1cc2ncc(-c3ccc(N)cn3)n2cc1S(=O)(=O)C(C)(C)C			786354	6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)pyridin- 3-amine::US20250346593, Example 71	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786354&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573826	COc1cn2ncc(-c3ccc(N)nc3F)c2cc1S(=O)(=O)C(C)(C)C			786355	5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1,5- a]pyridin-3-yl)-6- fluoropyridin-2-amine::US20250346593, Example 72	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786355&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573827	COc1cc2ncc(-c3cnc(N)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786356	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoropyridin-2-amine::US20250346593, Example 73	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786356&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573828	COc1cc2ncc(-c3cc(OC)c(N)nc3F)n2cc1S(=O)(=O)C(C)(C)C			786357	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-3- methoxypyridin-2- amine::US20250346593, Example 74	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786357&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573829	COc1cc2ncc(-c3cc(Cl)c(N)nc3F)n2cc1S(=O)(=O)C(C)(C)C			786358	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- chloro-6-fluoropyridin- 2-amine::US20250346593, Example 75	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786358&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573830	COc1cc2ncc(-c3ccc(N)c(OC)c3F)n2cc1S(=O)(=O)C(C)(C)C			786359	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoro-2- methoxyaniline::US20250346593, Example 76	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786359&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573831	COc1cc2ncc(-c3ccc(N(C)C)nc3F)n2cc1S(=O)(=O)C(C)(C)C			786360	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-N,N- dimethylpyridin-2- amine::US20250346593, Example 77	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786360&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573832	COc1cc(N)ncc1-c1cnc2cc(OC)c(S(=O)(=O)C(C)(C)C)cn12			786361	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-4- methoxypyridin-2- amine::US20250346593, Example 78	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786361&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573833	COc1cc2ncc(-c3ccc(N)nc3OC)n2cc1S(=O)(=O)C(C)(C)C			786362	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- methoxypyridin-2- amine::US20250346593, Example 79	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786362&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573834	COc1cc2ncc(-c3cc(C#N)c(N)cc3F)n2cc1S(=O)(=O)C(C)(C)C			786363	2-amino-5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-4- fluorobenzonitrile::US20250346593, Example 80	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786363&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573835	COc1cc2ncc(-c3cc(F)c(N)cc3F)n2cc1S(=O)(=O)C(C)(C)C			786364	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,5- difluoroaniline::US20250346593, Example 81	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786364&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573836	COc1cc2ncc(-c3cc(F)c(N)nc3F)n2cc1S(=O)(=O)C(C)(C)C			786365	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3,6- difluoropyridin-2- amine::US20250346593, Example 82	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786365&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573837	COc1cc2ncc(-c3ccc(N)c(F)c3F)n2cc1S(=O)(=O)C(C)(C)C			786366	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,3- difluoroaniline::US20250346593, Example 83	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786366&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573838	COc1cc2ncc(-c3cnc(N)c(C4CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786367	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- cyclopropylpyridin-2- amine::US20250346593, Example 84	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786367&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573839	COc1cc2ncc(-c3ccc(N)c(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C			786368	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- chloroaniline::US20250346593, Example 85	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786368&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573840	COc1cc2ncc(-c3ccc(N)c(Cl)c3F)n2cc1S(=O)(=O)C(C)(C)C			786369	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- chloro-3-fluoroaniline::US20250346593, Example 86	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786369&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573841	COc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)ccc1N			786370	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- methoxyaniline::US20250346593, Example 87	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786370&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573842	COc1cc2ncc(-c3cnc(N)c(OC(F)(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786371	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- (trifluoromethoxy) pyridin-2-amine::US20250346593, Example 88	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786371&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573843	COc1cc2ncc(-c3ccc(N)c(OC(F)(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786372	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- (trifluoromethoxy)aniline::US20250346593, Example 89	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786372&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573844	COc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c(F)cc1N			786373	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- fluoro-2- methoxyaniline::US20250346593, Example 90	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786373&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573845	COc1cc2ncc(-c3ccc(N)c(C#N)c3F)n2cc1S(=O)(=O)C(C)(C)C			786374	6-amino-3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluorobenzonitrile::US20250346593, Example 91	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786374&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573846	COc1cc2ncc(-c3cnc(N)c(CO)c3)n2cc1S(=O)(=O)C(C)(C)C			786375	(2-amino-5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)pyridin- 3-yl)methanol::US20250346593, Example 92	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786375&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573847	COc1cc2ncc(-c3cnc(N)nc3)n2cc1S(=O)(=O)C(C)(C)C			786376	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)pyrimidin-2-amine::US20250346593, Example 93	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786376&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573848	CNc1ncc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc1F			786377	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoro-N- methylpyridin-2-amine::US20250346593, Example 94	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786377&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573849	COc1cn2ncc(-c3ccc(N)c(C#N)c3)c2cc1S(=O)(=O)C(C)(C)C			786378	2-amino-5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1,5- a]pyridin-3- yl)benzonitrile::US20250346593, Example 95	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786378&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573850	COc1cc2ncc(-c3cc(C)c(N)nc3F)n2cc1S(=O)(=O)C(C)(C)C			786379	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-3- methylpyridin-2-amine::US20250346593, Example 96	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786379&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573851	COc1cn2ncc(-c3cnc(N)c(F)c3)c2cc1S(=O)(=O)C(C)(C)C			786380	5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1,5- a]pyridin-3-yl)-3- fluoropyridin-2-amine::US20250346593, Example 97	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786380&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573852	COc1cc2ncc(-c3cnc(N)c(C(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786381	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- (difluoromethyl)pyridin- 2-amine::US20250346593, Example 98	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786381&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573853	COc1cc2ncc(-c3ccc(N)nc3Cl)n2cc1S(=O)(=O)C(C)(C)C			786382	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- chloropyridin-2-amine::US20250346593, Example 99	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786382&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573854	COc1cn2ncc(-c3cc(F)c(N)nc3F)c2cc1S(=O)(=O)C(C)(C)C			786383	5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1,5- a]pyridin-3-yl)-3,6- difluoropyridin-2- amine::US20250346593, Example 100	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786383&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573855	COc1cc2ncc(-c3ccc(N4CCOCC4)nc3F)n2cc1S(=O)(=O)C(C)(C)C			786384	4-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)morpholine::US20250346593, Example 101	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786384&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573856	COc1cc2ncc(-c3cc(Cl)c(N)nc3OC)n2cc1S(=O)(=O)C(C)(C)C			786385	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- chloro-6- methoxypyridin-2- amine::US20250346593, Example 102	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786385&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573857	COc1cc2ncc(-c3cnc(N)cn3)n2cc1S(=O)(=O)C(C)(C)C			786386	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)pyrazin- 2-amine::US20250346593, Example 103	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786386&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573858	COc1cn2ncc(-c3cc(OC)c(N)nc3F)c2cc1S(=O)(=O)C(C)(C)C			786387	5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1,5- a]pyridin-3-yl)-6- fluoro-3- methoxypyridin-2- amine::US20250346593, Example 104	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786387&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573859	COc1cn2ncc(-c3cc(Cl)c(N)nc3F)c2cc1S(=O)(=O)C(C)(C)C			786388	5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1,5- a]pyridin-3-yl)-3- chloro-6-fluoropyridin- 2-amine::US20250346593, Example 105	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786388&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573860	COc1cc2ncc(-c3cc(F)c(N)nc3OC)n2cc1S(=O)(=O)C(C)(C)C			786389	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoro-6- methoxypyridin-2- amine::US20250346593, Example 106	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786389&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573861	COc1cc2ncc(-c3cc(C#N)c(N)nc3F)n2cc1S(=O)(=O)C(C)(C)C			786390	2-amino-5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoronicotinonitrile::US20250346593, Example 107	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786390&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573862	COc1cc2ncc(-c3ccc(N)nc3C#N)n2cc1S(=O)(=O)C(C)(C)C			786391	6-amino-3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)picolinonitrile::US20250346593, Example 108	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786391&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573863	COc1cc2ncc(-c3cnc(N)c(C)n3)n2cc1S(=O)(=O)C(C)(C)C			786392	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- methylpyrazin-2-amine::US20250346593, Example 109	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786392&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573864	COc1cn2ncc(-c3cc(C#N)c(N)nc3F)c2cc1S(=O)(=O)C(C)(C)C			786393	2-amino-5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1,5- a]pyridin-3-yl)-6- fluoronicotinonitrile::US20250346593, Example 110	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786393&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573865	COc1cc2ncc(-c3cc(F)c(N)c(C)c3F)n2cc1S(=O)(=O)C(C)(C)C			786394	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3,6- difluoro-2- methylaniline::US20250346593, Example 111	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786394&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573866	CCOc1nc(N)c(F)cc1-c1cnc2cc(OC)c(S(=O)(=O)C(C)(C)C)cn12			786395	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- ethoxy-3-fluoropyridin- 2-amine::US20250346593, Example 112	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786395&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573867	COc1cc2ncc(-c3cc(F)c(N)nc3OC(C)C)n2cc1S(=O)(=O)C(C)(C)C			786396	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoro-6- isopropoxypyridin-2- amine::US20250346593, Example 113	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786396&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573868	CCOc1cn2ncc(-c3cc(Cl)c(N)nc3F)c2cc1S(=O)(=O)C(C)(C)C			786397	5-(5-(tert- butylsulfonyl)-6- ethoxypyrazolo[1,5- a]pyridin-3-yl)-3- chloro-6-fluoropyridin- 2-amine::US20250346593, Example 114	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786397&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573869	CCOc1cn2ncc(-c3cc(F)c(N)nc3F)c2cc1S(=O)(=O)C(C)(C)C			786398	5-(5-(tert- butylsulfonyl)-6- ethoxypyrazolo[1,5- a]pyridin-3-yl)-3,6- difluoropyridin-2- amine::US20250346593, Example 115	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786398&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573870	CC(C)(C)S(=O)(=O)c1cn2c(-c3cc(F)c(N)nc3F)cnc2cc1OC(F)F			786399	5-(6-(tert- butylsulfonyl)-7- (difluoromethoxy)imid azo[1,2-a]pyridin-3- yl)-3,6-difluoropyridin- 2-amine::US20250346593, Example 116	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786399&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573871	CCOc1cc2ncc(-c3cnc(N)c(F)c3)n2cc1S(=O)(=O)C(C)C			786400	5-[6-ethoxy-5- (isopropylsulfonyl)- 1,3a-diaza-3-indenyl]- 3-fluoro-2- pyridylamine::US20250346593, Example 117	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786400&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573872	CCOc1cc2ncc(-c3cc(Cl)c(N)nc3F)n2cc1S(=O)(=O)C(C)C			786401	3-chloro-5-[6-ethoxy- 5-(isopropylsulfonyl)- 1,3a-diaza-3-indenyl]- 6-fluoro-2- pyridylamine::US20250346593, Example 118	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786401&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573873	CCOc1cc2ncc(-c3cc(F)c(N)nc3F)n2cc1S(=O)(=O)C(C)C			786402	5-[6-ethoxy-5- (isopropylsulfonyl)- 1,3a-diaza-3-indenyl]- 3,6-difluoro-2- pyridylamine::US20250346593, Example 119	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786402&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573874	CCOc1cc2ncc(-c3ccc(N)nc3F)n2cc1S(=O)(=O)C(C)C			786403	5-[6-ethoxy-5- (isopropylsulfonyl)- 1,3a-diaza-3-indenyl]- 6-fluoro-2- pyridylamine::US20250346593, Example 120	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786403&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573875	Nc1nc(F)c(-c2cnc3ccccn23)cc1F			786404	5-(1,3a-diaza-3- indenyl)-3,6-difluoro- 2-pyridylamine::US20250346593, Example 121	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786404&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573876	COc1cc2ncc(-c3cc(F)c(N)nc3F)n2cc1C1(F)CCN(C)CC1			786405	3,6-difluoro-5-[5-(4- fluoro-1-methyl-4- piperidyl)-6-methoxy- 1,3a-diaza-3-indenyl]- 2-pyridylamine::US20250346593, Example 122	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786405&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573877	COc1cc2ncc(-c3cc(F)c(N)nc3F)n2cc1S(=O)(=O)C(C)(C)CF			786406	3,6-difluoro-5-[5-(2- fluoro-1,1- dimethylethylsulfonyl)- 6-methoxy-1,3a-diaza- 3-indenyl]-2- pyridylamine::US20250346593, Example 123	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786406&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573878	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cn(C)c1=O			786407	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-1- methyl-2-oxo-1,2- dihydropyridin-3- yl)propane-1- sulfonamide::US20250346593, Example 124	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786407&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573879	COc1cc2ncc(-c3cc(NCCCO)c(=O)n(C)c3)n2cc1S(=O)(=O)C(C)(C)C			786408	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3-((3- hydroxypropyl)amino)- 1-methylpyridin-2(1H)- one::US20250346593, Example 125	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786408&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573880	COc1cc(N)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)n1			786409	2-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- methoxypyridin-4- amine::US20250346593, Example 126	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786409&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573881	COc1cc2ncc(-c3ccc(F)c(N)c3)n2cc1S(=O)(=O)C(C)(C)C			786410	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluoroaniline::US20250346593, Example 127	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786410	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786410&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573882	COc1cc2ncc(-c3cnc(N)c(N)n3)n2cc1S(=O)(=O)C(C)(C)C			786411	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)pyrazine-2,3- diamine::US20250346593, Example 128	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786411&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573883	COc1cc2ncc(-c3cc(F)nc(OCCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786412	3-({6-fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]pyridin- 2-yl}oxy)propan-1-ol::US20250346593, Example 129	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786412&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573884	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)ccc1OC			786413	N-{2-methoxy-5-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]phenyl}propane-1- sulfonamide::US20250346593, Example 130	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786413&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573885	CCCS(=O)(=O)Nc1cc(OC)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786414	N-{3-methoxy-5-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]phenyl}propane-1- sulfonamide::US20250346593, Example 131	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786414&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573886	CCCS(=O)(=O)Nc1cc(OC)cc(-c2cnc3cc(OCC)c(S(=O)(=O)C(C)C)cn23)c1			786415	N-{3-[7-ethoxy-6- (propane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-5- methoxyphenyl}propane- 1-sulfonamide::US20250346593, Example 132	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786415	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786415&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573887	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OCC)c(S(=O)(=O)C(C)C)cn23)ccc1OC			786416	N-{5-[7-ethoxy-6- (propane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-2- methoxyphenyl}propane- 1-sulfonamide::US20250346593, Example 133	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786416&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573888	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)ccc1OC(F)(F)F			786417	N-{5-[7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-2- (trifluoromethoxy) phenyl}propane-1- sulfonamide::US20250346593, Example 134	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786417&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573889	CCCS(=O)(=O)Nc1cc(OC(F)(F)F)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786418	N-{3-[7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-5- (trifluoromethoxy) phenyl}propane-1- sulfonamide::US20250346593, Example 135	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786418&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573890	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(OC)c1C			786419	N-(5-(6-(tert- Butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- methoxy-2- methylphenyl)propane- 1-sulfonamide::US20250346593, Example 136	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786419&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573891	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(C(=O)N(C)C)cn23)cc(OC)c1OC			786420	3-[3,4-dimethoxy-5- (propane-1- sulfonamido)phenyl]-7- methoxy-N,N- dimethylimidazo[1,2- a]pyridine-6- carboxamide::US20250346593, Example 137	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786420&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573892	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(OC(F)(F)F)c1F			786421	N-{2-fluoro-5-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-3- (trifluoromethoxy) phenyl}propane-1- sulfonamide::US20250346593, Example 138	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786421&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573893	CCCS(=O)(=O)Nc1cc(-c2cnn3ccc(S(=O)(=O)C(C)(C)C)cc23)cc(OC)c1OC			786422	N-(5-(5-(tert- butylsulfonyl)pyrazolo  [1,5-a]pyridin-3-yl)-2,3- dimethoxyphenyl) propane-1-sulfonamide::US20250346593, Example 139	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786422&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573894	CCCS(=O)(=O)Nc1cc(-c2cnn3cc(OC)c(S(=O)(=O)C(C)(C)C)cc23)cc(OC)c1OC			786423	N-(5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1,5- a]pyridin-3-yl)-2,3- dimethoxyphenyl) propane-1-sulfonamide::US20250346593, Example 140	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786423&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573895	COc1cn2ncc(-c3cc(NS(C)(=O)=O)c(OC)c(OC)c3)c2cc1S(=O)(=O)C(C)(C)C			786424	N-(5-(5-(tert- butylsulfonyl)-6- methoxypyrazolo[1,5- a]pyridin-3-yl)-2,3- dimethoxyphenyl) methanesulfonamide::US20250346593, Example 141	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786424&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573896	COc1cc2ncc(-c3ccc(N)c(OC(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786425	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- (difluoromethoxy)aniline::US20250346593, Example 142	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786425&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573897	CCc1ccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc1NS(C)(=O)=O			786426	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2-a] pyridin-3-yl)-2- ethylphenyl) methanesulfonamide::US20250346593, Example 143	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786426&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573898	CCCS(=O)(=O)Nc1cc(-c2cnc3ccccn23)cc(F)c1OC			786427	N-(3-fluoro-5- (imidazo[1,2-a]pyridin- 3-yl)-2- methoxyphenyl) propane-1-sulfonamide::US20250346593, Example 144	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786427&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573899	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(OC(F)F)n1			786428	N-(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- (difluoromethoxy) pyridin-2-yl)propane-1- sulfonamide::US20250346593, Example 145	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786428&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573900	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(C(C)(C)O)cn23)cc(F)c1OC			786429	N-(3-fluoro-5-(6-(2- hydroxypropan-2-yl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- methoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 146	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786429&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573901	CCCCOc1c(F)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc1NS(C)(=O)=O			786430	N-(2-(benzyloxy)-5-(6- (tert-butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluorophenyl) methanesulfonamide::US20250346593, Example 147	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786430&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573902	COc1cc2ncc(-c3ccc(NS(C)(=O)=O)nc3)n2cc1S(=O)(=O)C(C)(C)C			786431	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)pyridin- 2- yl)methanesulfonamide::US20250346593, Example 148	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786431&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573903	COc1cc2ncc(-c3ccc(O)cc3)n2cc1S(=O)(=O)C(C)(C)C	InChI=1S/C18H20N2O4S/c1-18(2,3)25(22,23)16-11-20-14(12-5-7-13(21)8-6-12)10-19-17(20)9-15(16)24-4/h5-11,21H,1-4H3	YNHYIKTXFQHPKP-UHFFFAOYSA-N	50279320	CHEMBL4163484::US20250346593, Example 149	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279320&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search			145957053	406793710							1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573904	COc1cc2ncc(-c3ccc(O)nc3)n2cc1S(=O)(=O)C(C)(C)C			786433	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)pyridin- 2-ol::US20250346593, Example 150	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786433&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573905	COc1cc2ncc(-c3cccc(S(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786434	6-(tert-butylsulfonyl)- 7-methoxy-3-(3- (methylsulfonyl)phenyl) imidazo[1,2- a]pyridine::US20250346593, Example 151	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786434&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573906	COc1cc2ncc(-c3ccc(S(N)(=O)=O)cc3)n2cc1S(=O)(=O)C(C)(C)C			786435	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)benzenesulfonamide::US20250346593, Example 152	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786435&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573907	COc1cc2ncc(-c3cccc(S(N)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786436	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)benzenesulfonamide::US20250346593, Example 153	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786436&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573908	COc1cc2ncc(-c3cc(F)c(N)nc3F)n2cc1S(=O)(=O)C(C)(C)C(F)F			786437	5-(6-((1,1-difluoro-2- methylpropan-2- yl)sulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3,6- difluoropyridin-2- amine::US20250346593, Example 154	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786437&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573909	CCOc1cc2ncc(-c3cc(F)c(N)nc3C)n2cc1S(=O)(=O)C(C)C			786438	5-(7-ethoxy-6- (isopropylsulfonyl) imidazo [1,2-a]pyridin-3- yl)-3-fluoro-6- methylpyridin-2-amine::US20250346593, Example 155	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786438&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573910	COc1cc2ncc(-c3cccc(CS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786439	6-(tert-butylsulfonyl)- 7-methoxy-3-(3- ((methylsulfonyl)methyl) phenyl)imidazo[1,2- a]pyridine::US20250346593, Example 156	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786439&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573911	COc1cc2ncc(-c3cc(N)cc(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786440	3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- fluoroaniline::US20250346593, Example 157	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786440&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573912	COc1cc2ncc(-c3ccc(OC)c(Cl)n3)n2cc1S(=O)(=O)C(C)(C)C			786441	6-(tert-butylsulfonyl)- 3-(6-chloro-5- methoxypyridin-2-yl)- 7-methoxyimidazo[1,2- a]pyridine::US20250346593, Example 158	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786441&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573913	COc1cc2ncc(-c3cc(Cl)ncc3C)n2cc1S(=O)(=O)C(C)(C)C			786442	US20250346593, Example 159	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786442&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573914	CCCS(=O)(=O)Nc1nc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)ccc1CC			786443	N-(6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- ethylpyridin-2- yl)propane-1- sulfonamide::US20250346593, Example 160	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786443&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573915	CCCS(=O)(=O)Nc1cc(OC)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)n1			786444	N-(6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-4- methoxypyridin-2- yl)propane-1- sulfonamide::US20250346593, Example 161	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786444&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573916	CNc1ccnc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786445	2-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-N- methylpyridin-4- amine::US20250346593, Example 162	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786445&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573917	CCCS(=O)(=O)Nc1nc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)ccc1C			786446	N-(6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- methylpyridin-2- yl)propane-1- sulfonamide::US20250346593, Example 163	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786446&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573918	COc1cc2ncc(-c3cnc(N)c(F)c3F)n2cc1S(=O)(=O)C(C)(C)C			786447	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3,4- difluoropyridin-2- amine::US20250346593, Example 164	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786447&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573919	COc1cc2ncc(-c3csc(N)n3)n2cc1S(=O)(=O)C(C)(C)C			786448	US20250346593, Example 165	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786448&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573920	COc1cc2ncc(-c3cnc(N)s3)n2cc1S(=O)(=O)C(C)(C)C			786449	5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)thiazol-2-amine::US20250346593, Example 166	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786449&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573921	COc1cc2ncc(-c3cc(F)c(N)nc3O)n2cc1S(=O)(=O)C(C)(C)C			786450	6-amino-3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- fluoropyridin-2-ol::US20250346593, Example 167	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786450&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573922	COc1ccc(CNc2cc(-c3cnc4ccc(S(=O)(=O)C(C)(C)C)cn34)cc(F)n2)cc1			786451	US20250346593, Example 168	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786451&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573923	COc1cc2ncc(-c3cc(F)nc(NCC[C@@H](C)O)c3)n2cc1S(=O)(=O)C(C)(C)C			786452	US20250346593, Example 169	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786452&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573924	COc1cc2ncc(-c3cc(F)nc(NCC[C@H](C)O)c3)n2cc1S(=O)(=O)C(C)(C)C			786453	US20250346593, Example 170	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786453&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573925	CC(C)(C)S(=O)(=O)c1ccc2ncc(-c3cc(F)nc(NCCC4(O)CCC4)c3)n2c1			786454	1-(2-((4-(6-(tert- butylsulfonyl)imidazo [1,2-a]pyridin-3- yl)-6-fluoropyridin- 2- yl)amino)ethyl)cyclo- butan-1-ol::US20250346593, Example 171	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786454&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573926	CC(C)(C)S(=O)(=O)c1ccc2ncc(-c3cc(F)nc(NCCC4(O)CC4)c3)n2c1			786455	1-(2-((4-(6-(tert- butylsulfonyl)imidazo [1,2-a]pyridin-3- yl)-6-fluoropyridin- 2- yl)amino)ethyl)cyclo- propan-1-ol::US20250346593, Example 172	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786455&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573927	CC(C)(C)S(=O)(=O)c1ccc2ncc(-c3cc(F)nc(NCCCO)c3)n2c1			786456	3-((4-(6-(tert- butylsulfonyl)imidazo [1,2-a]pyridin-3- yl)-6-fluoropyridin- 2-yl)amino)propan- 1-ol::US20250346593, Example 173	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786456&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573928	CC(C)(O)CCNc1cc(-c2cnc3ccc(S(=O)(=O)C(C)(C)C)cn23)cc(F)n1			786457	4-((4-(6-(tert- butylsulfonyl)imidazo [1,2-a]pyridin-3- yl)-6-fluoropyridin- 2-yl)amino)-2- methylbutan-2-ol::US20250346593, Example 174	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786457&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573929	COc1cc2ncc(-c3cc(F)nc(NCc4ccccc4)c3)n2cc1S(=O)C(C)(C)C			786458	N-benzyl-4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- amine::US20250346593, Example 175	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786458&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573930	COc1cc2ncc(-c3cc(F)nc(NCCC(C)(C)OC)c3)n2cc1S(=O)(=O)C(C)(C)C			786459	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-N-(3- methoxy-3- methylbutyl)pyridin- 2-amine::US20250346593, Example 176	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786459&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573931	COc1cc2ncc(-c3cc(F)nc(NC4CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786460	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-N- cyclopropyl-6- fluoropyridin-2- amine::US20250346593, Example 177	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786460&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573932	COc1cc2ncc(-c3cc(F)nc(NC(C)C)c3)n2cc1S(=O)(=O)C(C)(C)C			786461	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-N- isopropylpyridin-2- amine::US20250346593, Example 178	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786461&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573933	CNc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(F)n1			786462	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-N- methylpyridin-2- amine::US20250346593, Example 179	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786462&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573934	COc1cc2ncc(-c3cc(F)nc(NC4CCC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786463	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-N- cyclobutyl-6- fluoropyridin-2- amine::US20250346593, Example 180	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786463&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573935	CCCNc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(F)n1			786464	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-N- propylpyridin-2- amine::US20250346593, Example 181	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786464&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573936	COc1cc2ncc(-c3cc(F)nc(NCCCC(C)(C)O)c3)n2cc1S(=O)(=O)C(C)(C)C			786465	5-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)-2- methylpentan-2-ol::US20250346593, Example 182	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786465&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573937	COc1cc2ncc(-c3cc(F)nc(NCCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786466	3-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)propan-1- ol::US20250346593, Example 183	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786466&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573938	COc1cc2ncc(-c3cc(F)nc(NCc4ccc(=O)[nH]c4)c3)n2cc1S(=O)(=O)C(C)(C)C			786467	5-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)methyl) pyridin-2(1H)-one::US20250346593, Example 184	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786467&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573939	COc1cc2ncc(-c3cc(F)nc(NCC4CCC(=O)NC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786468	5-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)methyl) piperidin-2-one::US20250346593, Example 185	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786468&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573940	COc1cc2ncc(-c3cc(F)nc(N(C)C)c3)n2cc1S(=O)(=O)C(C)(C)C			786469	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-N,N- dimethylpyridin-2- amine::US20250346593, Example 186	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786469&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573941	COc1cc2ncc(-c3cc(F)nc(NCCC4(O)CCC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786470	1-(2-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)ethyl)cyclo- butan-1-ol::US20250346593, Example 187	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786470&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573942	COc1cc2ncc(-c3cc(F)nc(NCC4CCNC(=O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786471	4-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)methyl) piperidin-2-one::US20250346593, Example 188	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786471&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573943	COc1cc2ncc(-c3cc(F)nc(NCCC(C)(C)O)c3)n2cc1S(=O)(=O)C(C)(C)C			786472	4-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)-2- methylbutan-2-ol::US20250346593, Example 189	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786472&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573944	COc1cc2ncc(-c3cc(F)nc(NCCC(C)O)c3)n2cc1S(=O)(=O)C(C)(C)C			786473	rac-4-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)butan-2-ol::US20250346593, Example 190	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786473&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573945	COc1cc2ncc(-c3cc(F)nc(NC4CC(O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786474	(1s,3s)-3-((4-(6- (tert-butylsulfonyl)- 7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)cyclobutan- 1-ol::US20250346593, Example 191	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786474&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573946	COc1cc2ncc(-c3cc(F)nc(NC4CC[C@H](O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786475	rac-(1R,3S)-3-((4-(6- (tert-butylsulfonyl)- 7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)cyclopentan- 1-ol::US20250346593, Example 192	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786475&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573947	COc1cc2ncc(-c3cc(F)nc(N[C@H]4C[C@H](O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786476	(1r,3r)-3-((4-(6- (tert-butylsulfonyl)- 7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)cyclobutan- 1-ol::US20250346593, Example 193	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786476&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573948	COc1cc2ncc(-c3cc(F)nc(NCCCN)c3)n2cc1S(=O)(=O)C(C)(C)C			786477	N1-(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)propane-1,3- diamine::US20250346593, Example 194	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786477&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573949	COc1cc2ncc(-c3cc(F)nc(NC[C@@H](O)CO)c3)n2cc1S(=O)(=O)C(C)(C)C			786478	(R)-3-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)propane- 1,2-diol::US20250346593, Example 195	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786478&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573950	COc1cc2ncc(-c3cc(F)nc(NCc4ccn(C)c(=O)c4)c3)n2cc1S(=O)(=O)C(C)(C)C			786479	4-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)methyl)-1- methylpyridin- 2(1H)-one::US20250346593, Example 196	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786479&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573951	COc1cc2ncc(-c3cc(F)nc(NC4CC[C@@H](O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786480	rac-(1R,3R)-3-((4- (6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)cyclopentan- 1-ol::US20250346593, Example 197	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786480&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573952	COc1cc2ncc(-c3cc(F)nc(NCCC4(O)CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786481	1-(2-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)ethyl)cyclo- propan-1-ol::US20250346593, Example 198	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786481&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573953	COc1cc2ncc(-c3cc(F)nc(NCc4cc[nH]c(=O)c4)c3)n2cc1S(=O)(=O)C(C)(C)C			786482	4-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)methyl) pyridin-2(1H)-one::US20250346593, Example 199	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786482&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573954	COc1cc2ncc(-c3cc(F)nc(NCC4CCN(C)C(=O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786483	4-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)methyl)-1- methylpiperidin-2- one::US20250346593, Example 200	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786483&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573955	COc1cc2ncc(-c3cc(F)nc(NCC4(CO)CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786484	(1-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)methyl)cyclo- propyl)methanol::US20250346593, Example 201	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786484&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573956	COc1cc2ncc(-c3cc(F)nc(NCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786485	2-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)ethan-1-ol::US20250346593, Example 202	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786485&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573957	COc1cc2ncc(-c3cc(F)nc(NC[C@H](O)CO)c3)n2cc1S(=O)(=O)C(C)(C)C			786486	(S)-3-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)propane- 1,2-diol::US20250346593, Example 203	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786486&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573958	COc1cc2ncc(-c3cc(F)nc(NC4CCC(O)CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786487	(1r,4r)-4-((4-(6- (tert-butylsulfonyl)- 7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)cyclohexan- 1-ol::US20250346593, Example 204	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786487&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573959	COc1cc2ncc(-c3cc(F)nc(NC4CCC[C@@H](O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786488	rac-(1R,3R)-3-((4- (6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)cyclohexan- 1-ol::US20250346593, Example 205	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786488&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573960	COc1cc2ncc(-c3cc(F)nc(NC4CCC(O)CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786489	(1s,4s)-4-((4-(6- (tert-butylsulfonyl)- 7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)cyclohexan- 1-ol::US20250346593, Example 206	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786489&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573961	COc1cc2ncc(-c3cc(F)nc(N4CCC(O)CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786490	1-(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)piperidin-4-ol::US20250346593, Example 207	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786490&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573962	COc1cc2ncc(-c3cc(F)nc(NCC4(O)CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786491	1-(((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)methyl) cyclopropan-1-ol::US20250346593, Example 208	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786491&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573963	COc1cc2ncc(-c3cc(F)nc(N(C)CCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786492	3-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)(methyl)amino) propan-1-ol::US20250346593, Example 209	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786492&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573964	COc1cc2ncc(-c3cc(F)nc(NCCN4CCCC4=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786493	1-(2-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)ethyl) pyrrolidin-2-one::US20250346593, Example 210	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786493&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573965	COc1cc2ncc(-c3cc(F)nc(N4CCOCC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786494	4-(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)morpholine::US20250346593, Example 211	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786494&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573966	COc1cc2ncc(-c3cc(F)nc(NC4CCOCC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786495	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-N- (tetrahydro-2H- pyran-4-yl)pyridin- 2-amine::US20250346593, Example 212	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786495&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573967	COc1cc2ncc(-c3cc(F)nc(NCCC4(O)COC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786496	3-(2-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)ethyl)oxetan- 3-ol::US20250346593, Example 213	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786496&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573968	COc1cc2ncc(-c3cc(F)c(C#N)c(NCCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786497	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluoro-6-((3- hydroxypropyl)amino) benzonitrile::US20250346593, Example 214	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786497&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573969	COc1cc2ncc(-c3cc(N)nc(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786498	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- amine::US20250346593, Example 215	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786498&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573970	COc1ccc(CNc2cc(-c3cnc4cc(OC)c(S(=O)(=O)C(C)(C)C)cn34)cc(F)n2)cc1			786499	6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-N-(4- methoxybenzyl) pyridin-2-amine::US20250346593, Example 216	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786499&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573971	COc1cc2ncc(-c3cc(F)nc(N4CC5(C4)CC(O)(C(F)(F)F)C5)c3)n2cc1S(=O)(=O)C(C)(C)C			786500	2-{6-fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2-yl}-6- (trifluoromethyl)-2- azaspiro[3.3]heptan- 6-ol::US20250346593, Example 217	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786500&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573972	COc1cc2ncc(-c3cc(F)nc(N4CC5(CC(O)C5)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786501	2-{6-fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2-yl}-2- azaspiro[3.3]heptan- 6-o1::US20250346593, Example 218	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786501&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573973	COc1cc2ncc(-c3cc(F)nc(N[C@H]4C[C@H](OC)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786502	6-fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-N- [(trans)-3- methoxycyclobutyl] pyridin-2-amine::US20250346593, Example 219	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786502&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573974	COc1cc2ncc(-c3cc(F)nc(N[C@H]4C[C@@H](OC)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786503	6-fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-N- [cis-3- methoxycyclobutyl] pyridin-2-amine::US20250346593, Example 220	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786503&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573975	COc1cc2ncc(-c3cc(F)nc(N[C@H](C)CO)c3)n2cc1S(=O)(=O)C(C)(C)C			786504	(2R)-2-({6-fluoro-4- [7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)propan-1- ol::US20250346593, Example 221	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786504&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573976	COc1cc2ncc(-c3cc(F)nc(N[C@@H](C)CO)c3)n2cc1S(=O)(=O)C(C)(C)C			786505	(2S)-2-({6-fluoro-4- [7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)propan-1- ol::US20250346593, Example 222	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786505&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573977	COc1cc2ncc(-c3cc(F)nc(N4CCN(C)CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786506	1-{6-fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2-yl}-4- methylpiperazine::US20250346593, Example 223	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786506&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573978	COc1cc2ncc(-c3cc(F)nc(NCC(C)(C)O)c3)n2cc1S(=O)(=O)C(C)(C)C			786507	1-({6-fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)-2- methylpropan-2-ol::US20250346593, Example 224	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786507&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573979	COc1cc2ncc(-c3cc(F)nc(NC4CCCC[C@H]4O)c3)n2cc1S(=O)(=O)C(C)(C)C			786508	Mixture of 2 Enantiomers, trans: (1R,2R & 1S,2S)-2- ((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)cyclohexan- 1-ol::US20250346593, Example 225	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786508&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573980	COc1cc2ncc(-c3cc(F)nc(NC[C@@H](C)O)c3)n2cc1S(=O)(=O)C(C)(C)C			786509	(2R)-1-({6-fluoro-4- [7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)propan-2- ol::US20250346593, Example 226	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786509&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573981	COc1cc2ncc(-c3cc(F)nc(NC[C@H](C)O)c3)n2cc1S(=O)(=O)C(C)(C)C			786510	(2S)-1-({6-fluoro-4- [7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)propan-2- ol::US20250346593, Example 227	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786510&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573982	COc1cc2ncc(-c3cc(F)nc(NCC(F)(F)CO)c3)n2cc1S(=O)(=O)C(C)(C)C			786511	2,2-difluoro-3-({6- fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)propan-1- ol::US20250346593, Example 228	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786511&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573983	COc1cc2ncc(-c3cc(F)nc(NC[C@@H](F)CO)c3)n2cc1S(=O)(=O)C(C)(C)C			786512	(2R)-2-fluoro-3-({6- fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)propan-1- ol::US20250346593, Example 229	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786512&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573984	COc1cc2ncc(-c3cc(F)nc(N[C@H](C)CCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786513	(3R)-3-({6-fluoro-4- [7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)butan-1-ol::US20250346593, Example 230	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786513&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573985	COc1cc2ncc(-c3cc(F)nc(NC[C@H](F)CO)c3)n2cc1S(=O)(=O)C(C)(C)C			786514	(2S)-2-fluoro-3-({6- fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)propan-1- ol::US20250346593, Example 231	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786514&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573986	COc1cc2ncc(-c3cc(NCCCO)nc(C(F)(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786515	3-({4-[7-methoxy-6- (2-methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-6- (trifluoromethyl)pyridin- 2- yl}amino)propan-1- ol::US20250346593, Example 232	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786515&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573987	COc1cc2ncc(-c3cc(F)nc(NCCOC(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786516	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-N- (2- (difluoromethoxy) ethyl)-6-fluoropyridin- 2-amine::US20250346593, Example 233	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786516&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573988	COc1ccn2c(-c3cc(F)nc(NCCCO)c3)cnc2c1			786517	3-[(6-fluoro-4-{7- methoxyimidazo[1,2- a]pyridin-3- yl}pyridin-2- yl)amino]propan-1- ol::US20250346593, Example 234	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786517&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573989	COc1cc2ncc(-c3cc(F)nc(NCCSC)c3)n2cc1S(=O)(=O)C(C)(C)C			786518	4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoro-N-(2- (methylthio)ethyl) pyridin-2-amine::US20250346593, Example 235	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786518&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573990	COc1cc2ncc(-c3cc(F)nc(N[C@@H](C)CCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786519	(3S)-3-({6-fluoro-4- [7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)butan-1-ol::US20250346593, Example 236	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786519&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573991	COc1cc2ncc(-c3cc(F)nc(NC(C)(C)CO)c3)n2cc1S(=O)(=O)C(C)(C)C			786520	2-({6-fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)-2- methylpropan-1-ol::US20250346593, Example 237	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786520&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573992	COc1cc2ncc(-c3cc(F)nc(NC[C@@H]4CCNC(=O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786521	(4R or S)-4-[({6- fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)methyl]pi peridin-2-one (Enantiomer 1)::US20250346593, Example 238	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786521&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573993	COc1cc2ncc(-c3cc(F)nc(NC[C@H]4CCNC(=O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786522	(4R or S)-4-[({6- fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)methyl]pi peridin-2-one (Enantiomer 2)::US20250346593, Example 239	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786522&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573994	COc1cc2ncc(-c3cc(F)nc(NCC[C@H]4CNC(=O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786523	(4R or S)-4-[2-({6- fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)ethyl] pyrrolidin-2-one (Enantiomer 1)::US20250346593, Example 240	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786523&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573995	COc1cc2ncc(-c3cc(F)nc(NCC[C@@H]4CNC(=O)C4)c3)n2cc1S(=O)(=O)C(C)(C)C			786524	(4R or S)-4-[2-({6- fluoro-4-[7- methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)ethyl] pyrrolidin-2-one (Enantiomer 2)::US20250346593, Example 241	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786524&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573996	CCOc1cc2ncc(-c3cc(F)nc(NCCCO)c3)n2cc1C1(F)CCN(C)CC1			786525	3-({4-[7-ethoxy-6- (4-fluoro-1- methylpiperidin-4- yl)imidazo[1,2- a]pyridin-3-yl]-6- fluoropyridin-2- yl}amino)propan-1- ol::US20250346593, Example 242	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786525&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573997	CCOc1cc2ncc(-c3cc(F)nc(NCCCO)c3)n2cc1S(=O)(=O)C(C)C			786526	3-({4-[7-ethoxy-6- (propane-2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-6- fluoropyridin-2- yl}amino)propan-1- ol::US20250346593, Example 243	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786526&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573998	COc1cc2ncc(-c3cc(F)nc(N[C@@H]4CCCC[C@H]4O)c3)n2cc1S(=O)(=O)C(C)(C)C			786527	trans-(15,2S or 1R,2R)-2-({6-fluoro- 4-[7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)cyclohexan- 1-ol (Enantiomer 2)::US20250346593, Example 244	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786527&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1573999	COc1cc2ncc(-c3cc(F)nc(N[C@H]4CCCC[C@@H]4O)c3)n2cc1S(=O)(=O)C(C)(C)C			786528	trans-(15,2S or 1R,2R)-2-({6-fluoro- 4-[7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)cyclohexan- 1-ol (Enantiomer 1)::US20250346593, Example 245	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786528&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574000	CCOc1cc2ncc(-c3cc(F)nc(NCCC(O)CC)c3)n2cc1S(=O)(=O)C(C)C			786529	Rac-1-({4-[7- ethoxy-6-(propane- 2- sulfonyl)imidazo[1,2- a]pyridin-3-yl]-6- fluoropyridin-2- yl}amino)pentan-3- ol::US20250346593, Example 246	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786529&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574001	COc1cc2ncc(-c3ccnc(NCCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786530	3-({4-[7-methoxy-6- (2-methylpropane-2- sulfonyl)imidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)propan-1- ol::US20250346593, Example 247	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786530&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574002	COc1cc2ncc(-c3cc(F)nc(NCCCO)c3)n2cc1C(=O)N(C)C			786531	3-{2-fluoro-6-[(3- hydroxypropyl)amino ]pyridin-4-yl}-7- methoxy-N,N- dimethylimidazo[1,2- a]pyridine-6- carboxamide::US20250346593, Example 248	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786531&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574003	COc1cc2ncc(-c3cc(F)nc(NCC(C)(C)O)c3)n2cc1C(=O)N(C)C			786532	3-{2-fluoro-6-[(2- hydroxy-2- methylpropyl)amino] pyridin-4-yl}-7- methoxy-N,N- dimethylimidazo[1,2- a]pyridine-6- carboxamide::US20250346593, Example 249	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786532&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574004	COc1cc2ncc(-c3cc(F)nc(NCCCO)c3)n2cc1CO			786533	3-({6-fluoro-4-[6- (hydroxymethyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl]pyridin-2- yl}amino)propan-1- ol::US20250346593, Example 250	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786533&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574005	CNC(=O)c1cn2c(-c3cc(F)nc(NCCCO)c3)cnc2cc1OC			786534	3-{2-fluoro-6-[(3- hydroxypropyl)amin o]pyridin-4-yl}-7- methoxy-N- methylimidazo[1,2- a]pyridine-6- carboxamide::US20250346593, Example 251	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786534&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574006	COc1cc2ncc(-c3cc(NCCCO)cc(F)n3)n2cc1S(=O)(=O)C(C)(C)C			786535	3-((2-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-4- yl)amino)propan-1- ol::US20250346593, Example 252	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786535&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574007	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cnc1N			786536	US20250346593, Example 253	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786536&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574008	CCCS(=O)(=O)Nc1cncc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786537	5-(6-(tert-butylsulfonyl)- 7-methoxyimidazo[1,2- a]pridin-3-yl)pyridin-3- yl)propane-1-sulfonamide::US20250346593, Example 254	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786537&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574009	COc1cc2ncc(-c3ccc(F)c(NS(C)(=O)=O)c3F)n2cc1S(=O)(=O)C(C)(C)C			786538	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,6- difluorophenyl)propane-1- sulfonamide::US20250346593, Example 255	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786538&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574010	CCCS(=O)(=O)N(C)c1cccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786539	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)phenyl)-N- methylpropane-1- sulfonamide::US20250346593, Example 256	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786539&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574011	CCCS(=O)(=O)Nc1c(OC)ccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1F			786540	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2-fluoro- 6- methoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 257	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786540&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574012	CCCS(=O)(=O)Nc1cccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1F			786541	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluorophenyl)propane-1- sulfonamide::US20250346593, Example 258	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786541&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574013	COc1cc2ncc(-c3cc(C#N)c(OC)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786542	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3-cyano-2- methoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 259	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786542&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574014	COc1cc2ncc(-c3cc(C#N)c(OC)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786543	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3-cyano-2- methoxyphenyl)methane- sulfonamide::US20250346593, Example 260	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786543&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574015	COc1cc2ncc(-c3cccc(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786544	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)phenyl)methanesulfon- amide::US20250346593, Example 261	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786544&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574016	COc1cc2ncc(-c3cc(F)c(C)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786545	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3-fluoro- 2-methylphenyl)propane- 1-sulfonamide::US20250346593, Example 262	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786545&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574017	COc1cc2ncc(-c3cc(F)c(OC)c(NS(C)(=O)=O)c3F)n2cc1S(=O)(=O)C(C)(C)C			786546	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,5- difluoro-6- methoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 263	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786546&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574018	COc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(NS(C)(=O)=O)n1			786547	N-(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- methoxypyridin-2- yl)methanesulfonamide::US20250346593, Example 264	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786547&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574019	COc1cc2ncc(-c3cnc(OC)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786548	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- methoxypyridin-3- yl)propane-1-sulfonamide::US20250346593, Example 265	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786548&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574020	COc1cc2ncc(-c3cc(F)c(F)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786549	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,3- difluorophenyl)propane-1- sulfonamide::US20250346593, Example 266	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786549&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574021	COc1cc2ncc(-c3cc(NS(C)(=O)=O)c(F)c(OC)c3)n2cc1S(=O)(=O)C(C)(C)C			786550	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2-fluoro- 3- methoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 267	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786550&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574022	COc1cc2ncc(-c3cc(C)c(OC)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786551	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- methoxy-3- methylphenyl)propane-1- sulfonamide::US20250346593, Example 268	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786551&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574023	COc1cc2ncc(-c3cccc(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786552	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)phenyl)propane-1- sulfonamide::US20250346593, Example 269	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786552&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574024	CCOc1c(F)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc1NS(C)(=O)=O			786553	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2-ethoxy- 3-fluorophenyl)propane-1- sulfonamide::US20250346593, Example 270	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786553&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574025	COc1cc2ncc(-c3ccc(OC(F)F)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786554	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- (difluoromethoxy)phenyl) propane-1-sulfonamide::US20250346593, Example 271	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786554&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574026	COc1cc2ncc(-c3cc(F)c(OC)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786555	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3-fluoro- 2- methoxyphenyl)methane- sulfonamide::US20250346593, Example 272	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786555&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574027	COc1cc2ncc(-c3cc(F)cc(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786556	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- fluorophenyl)propane-1- sulfonamide::US20250346593, Example 273	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786556&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574028	COc1cc2ncc(-c3cc(NS(C)(=O)=O)c(OC)c(OC)c3)n2cc1S(=O)(=O)C1CC1			786557	N-(5-(6- (cyclopropylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,3- dimethoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 274	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786557&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574029	COc1cc2ncc(-c3cc(F)c(OC)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786558	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3-fluoro- 2- methoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 275	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786558&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574030	COc1cc2ncc(-c3cccc(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786559	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)phenyl)ethanesulfon- amide::US20250346593, Example 276	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786559&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574031	COc1cc2ncc(-c3cccc(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786560	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)phenyl)-2- methylpropane-2- sulfonamide::US20250346593, Example 277	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786560&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574032	COc1cc2ncc(-c3cccc(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786561	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3- yl)phenyl)propane-2- sulfonamide::US20250346593, Example 278	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786561&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574033	COc1cc2ncc(-c3cc(F)c(OC)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786562	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3-fluoro- 2-methoxyphenyl)-2- methylpropane-1- sulfonamide::US20250346593, Example 279	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786562&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574034	COc1cc2ncc(-c3cccc(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786563	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)phenyl)-2- methylpropane-1- sulfonamide::US20250346593, Example 280	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786563&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574035	COc1ccc(-c2cnn3ccc(S(=O)(=O)C(C)(C)C)cc23)cc1NS(C)(=O)=O			786564	N-(5-(5-(tert- butylsulfonyl)pyrazolo[1, 5-a]pyridin-3-yl)-2- methoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 281	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786564&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574036	CCCS(=O)(=O)Nc1cc(C#N)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786565	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- cyanophenyl)propane-1- sulfonamide::US20250346593, Example 282	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786565&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574037	COc1cc(NS(C)(=O)=O)cc(-c2cnn3ccc(S(=O)(=O)C(C)(C)C)cc23)c1			786566	N-(3-(5-(tert- butylsulfonyl)pyrazolo[1, 5-a]pyridin-3-yl)-5- methoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 283	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786566&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574038	COc1cc2ncc(-c3cc(F)c(OC(F)F)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786567	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- (difluoromethoxy)-3- fluorophenyl)propane-1- sulfonamide::US20250346593, Example 284	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786567&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574039	COc1cc2ncc(-c3cc(NS(C)(=O)=O)c(OC)c(OC)c3)n2cc1S(=O)(=O)C(C)(C)C			786568	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,3- dimethoxyphenyl)methane sulfonamide::US20250346593, Example 285	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786568&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574040	COc1cc2ncc(-c3cnc(OC(F)F)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786569	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- (difluoromethoxy)pyridin- 3-yl)propane-1- sulfonamide::US20250346593, Example 286	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786569&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574041	CCCS(=O)(=O)Nc1ccc(F)c(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786570	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-4- fluorophenyl)propane-1- sulfonamide::US20250346593, Example 287	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786570&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574042	COc1ccc(-c2cnc3cc(OC)c(S(=O)(=O)C4CC4)cn23)cc1NS(C)(=O)=O			786571	N-(5-(6- (cyclopropylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- methoxyphenyl)propane- 1-sulfonamide::US20250346593, Example 288	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786571&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574043	COCc1cc(NS(C)(=O)=O)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1			786572	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- (methoxymethyl)phenyl) propane-1-sulfonamide::US20250346593, Example 289	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786572&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574044	COc1cc2ncc(-c3cc(C)c(F)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786573	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2-fluoro- 3-methylphenyl)propane- 1-sulfonamide::US20250346593, Example 290	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786573&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574045	COc1cc2ncc(-c3ccc(F)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786574	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- fluorophenyl)propane-1- sulfonamide::US20250346593, Example 291	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786574&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574046	COc1cc2ncc(-c3cc(F)cc(NS(C)(=O)=O)c3F)n2cc1S(=O)(=O)C(C)(C)C			786575	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2,5- difluorophenyl)propane-1- sulfonamide::US20250346593, Example 292	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786575&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574047	CCCS(=O)(=O)Nc1ccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc1OC(F)F			786576	N-(4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-2- (difluoromethoxy)phenyl) propane-1-sulfonamide::US20250346593, Example 293	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786576&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574048	COc1cc2ncc(-c3cc(F)c(OC)c(NS(C)(=O)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786577	N-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3-fluoro- 2- methoxyphenyl)ethane- sulfonamide::US20250346593, Example 294	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786577&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574049	COc1cc2ncc(-c3cc(NS(C)(=O)=O)cc(OC(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786578	N-(3-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-5- (difluoromethoxy)phenyl) propane-1-sulfonamide::US20250346593, Example 295	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786578&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574050	CC(C)(C)S(=O)(=O)c1ccn2ncc(-c3cc(F)nc(NCCCO)c3)c2c1			786579	US20250346593, Example 296	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786579&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574051	CC(C)(C)S(=O)(=O)c1ccn2ncc(-c3ccc(NCCCO)nc3F)c2c1			786580	US20250346593, Example 297	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786580&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574052	CC(C)(C)S(=O)(=O)C1=CC2C(c3cc(N)nc(F)c3)C=NN2C=C1			786581	US20250346593, Example 298	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786581&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574053	CC(C)(C)S(=O)(=O)C1=CC2C(C3CC=C(F)N=C3N)C=NN2C=C1			786582	US20250346593, Example 299	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786582&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574054	CC(C)(C)S(=O)(=O)C1=CC2C(C3CC=C(N)N=C3F)C=NN2C=C1			786583	Example 301::US20250346593, Example 300	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786583&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574055	COc1cc2ncc(-c3cc(F)nc(NCC4CCNCC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786584	US20250346593, Example 301	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786584&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574056	COc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(F)n1			786585	US20250346593, Example 302	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786585&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574057	COc1cc2ncc(-c3cc(F)[nH]c(=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786586	US20250346593, Example 303	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786586&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574058	CCCS(=O)(=O)Nc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(F)n1			786587	US20250346593, Example 304	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786587&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574059	COc1cc2ncc(-c3cc(F)c(OC)c(Br)c3)n2cc1S(=O)(=O)C(C)(C)C			786588	US20250346593, Example 305	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786588&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574060	COc1cc2ncc(-c3cc(F)c(OCCO)c(Br)c3)n2cc1S(=O)(=O)C(C)(C)C			786589	US20250346593, Example 306	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786589&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574061	COc1cc2ncc(-c3cc(F)c(OC)c(N4CC[C@@H](O)C4=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786590	US20250346593, Example 307	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786590&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574062	COc1cc2ncc(-c3cc(F)c(OC)c(NCCNC(=O)OC(C)(C)C)c3)n2cc1S(=O)(=O)C(C)(C)C			786591	US20250346593, Example 308	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786591&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574063	COc1cc2ncc(-c3cc(NCCCO)ncc3C)n2cc1S(=O)(=O)C(C)(C)C			786592	US20250346593, Example 309	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786592&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574064	COc1cc2ncc(-c3cc(NCCCO)ncc3F)n2cc1S(=O)(=O)C(C)(C)C			786593	3-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1, 2-a]pyridin-3-yl)- 5-fluoropyridin-2- yl)amino)propan- 1-ol::US20250346593, Example 310	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786593&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574065	COc1cc2ncc(-c3cc(C)c(OC)c(NCCCO)n3)n2cc1S(=O)(=O)C(C)(C)C			786594	3-((6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1, 2-a]pyridin-3-yl)- 3-methoxy-4- methylpyridin-2- yl)amino)propan- 1-ol::US20250346593, Example 311	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786594&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574066	COc1cc2ncc(-c3ccc(OC)c(NCCCO)n3)n2cc1S(=O)(=O)C(C)(C)C			786595	3-((6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1, 2-a]pyridin-3-yl)- 3-methoxypyridin- 2- yl)amino)propan- 1-ol::US20250346593, Example 312	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786595&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574067	CCCS(=O)(=O)Nc1nc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)ccc1OC(F)(F)F			786596	US20250346593, Example 313	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786596&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574068	CCCS(=O)(=O)Nc1nc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)ccc1OC			786597	N-(6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1, 2-a]pyridin-3-yl)-3- methoxypyridin-2- yl)propane-1- sulfonamide::US20250346593, Example 314	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786597&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574069	COc1cc2ncc(-c3cc(F)nc(F)c3)n2cc1S(=N)(=O)C(C)(C)C			786598	US20250346593, Example 315	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786598&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574070	COc1cc2ncc(-c3cc(F)nc(NCCS(C)(=N)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786599	Rac-(2-((4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluoropyridin-2- yl)amino)ethyl)(imino) (methyl)-26-sulfanone::US20250346593, Example 316	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786599&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574071	COc1cc2ncc(-c3cc(F)nc(NCC4CCN(C(C)=O)CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786600	US20250346593, Example 317	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		<1							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786600&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574072	COc1cc2ncc(-c3cc(F)nc(NCCCNC(C)=O)c3)n2cc1S(=O)(=O)C(C)(C)C			786601	N-[3-({6-fluoro-4- [7-methoxy-6-(2- methylpropane-2- sulfonyl)imidazo [1,2-a]pyridin-3- yl]pyridin-2- yl}amino)propyl] acetamide::US20250346593, Example 318	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786601&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574073	COc1cc2ncc(-c3cc(F)c(OC)c(NCCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786602	US20250346593, Example 319	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786602&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574074	COc1cc2ncc(-c3cccc(NCCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786603	US20250346593, Example 320	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786603&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574075	COc1cc(NCCCO)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)n1			786604	3-((2-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1, 2-a]pyridin-3-yl)-6- methoxypyridin-4- yl)amino)propan-1- ol::US20250346593, Example 321	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786604&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574076	COc1cc2ncc(-c3cc(C)c(OC)c(NCCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786605	US20250346593, Example 322	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786605&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574077	COc1cc2ncc(-c3cnn(CCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786606	US20250346593, Example 323	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786606&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574078	COc1cc2ncc(-c3cnn(CCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786607	US20250346593, Example 324	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786607&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574079	CCCS(=O)(=O)N(C)c1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(OC)c1C			786608	US20250346593, Example 325	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786608&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574080	CNc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc(OC)c1OC			786609	US20250346593, Example 326	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786609&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574081	COc1cc2ncc(-c3cc(Cl)nc(NCCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786610	US20250346593, Example 327	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786610&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574082	COc1cc2ncc(-c3cc(N)c(=O)n(C(F)F)c3)n2cc1S(=O)(=O)C(C)(C)C			786611	3-amino-5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-1- (difluoromethyl) pyridin-2(1H)-one::US20250346593, Example 328	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786611&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574083	COc1cc2ncc(-c3cc(F)c(OC)c(NCCN)c3)n2cc1S(=O)(=O)C(C)(C)C			786612	N1-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoro-2- methoxyphenyl) ethane-1,2-diamine::US20250346593, Example 329	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786612&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574084	CC(C)(C)S(=O)(=O)c1ccc2ncc(-c3cc(N)nc(F)c3)n2c1			786613	US20250346593, Example 330	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786613&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574085	CCc1ccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)nc1N			786614	US20250346593, Example 331	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786614&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574086	COc1cc2ncc(-c3ccc(C)c(N)n3)n2cc1S(=O)(=O)C(C)(C)C			786615	6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- methylpyridin-2-amine::US20250346593, Example 332	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786615&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574087	COc1cc2ncc(-c3cc(N)c(C#N)c(F)c3)n2cc1S(=O)(=O)C(C)(C)C			786616	2-amino-4-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-6- fluorobenzonitrile::US20250346593, Example 333	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786616&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574088	COc1cc2ncc(-c3ccc(OC(F)(F)F)c(N)n3)n2cc1S(=O)(=O)C(C)(C)C			786617	US20250346593, Example 334	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786617&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574089	COc1cc2ncc(-c3cc(C)c(OC)c(N)c3)n2cc1S(=O)(=O)C(C)(C)C			786618	6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- methoxy-4- methylpyridin-2-amine::US20250346593, Example 335	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786618&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574090	COc1cc2ncc(-c3ccc(OC)c(N)n3)n2cc1S(=O)(=O)C(C)(C)C			786619	6-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- methoxypyridin-2- amine::US20250346593, Example 336	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		>20							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786619&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574091	COc1cc2ncc(-c3cc(F)c(OC)c(C(C)(C)O)c3)n2cc1S(=O)(=O)C(C)(C)C			786620	US20250346593, Example 337	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786620&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574092	COc1cc2ncc(-c3cc(F)c(OC)c(OCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786621	US20250346593, Example 338	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786621&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574093	COc1cc2ncc(-c3cc(F)c(OC)c(OCCCO)c3)n2cc1S(=O)(=O)C(C)(C)C			786622	3-(5-(6-(tert- butylsulfonyl)-7- methoxyimidazo[1,2- a]pyridin-3-yl)-3- fluoro-2- methoxyphenoxy) propan-1-ol::US20250346593, Example 339	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 11.25							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786622&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1574094	COc1cc2ncc(-c3cc(F)c(OC)c(C4CC4)c3)n2cc1S(=O)(=O)C(C)(C)C			786623	US20250346593, Example 340	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens		 1.75							Curated from the literature by BindingDB						n/a	11/13/2025	3/4/2026	n/a	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8039&target=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786623&enzyme=Receptor-interacting+serine%2Fthreonine-protein+kinase+2&column=ki&startPg=0&Increment=50&submit=Search											1	MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM	8AZA,9F3V,8X2O,6S1F,6FU5,6ES0,6SZJ,6SZE,6RNA,6RN8,6HMX,5J7B,5J79,5AR8,5AR7,5AR5,5AR4,5AR3,5AR2,5W5O,5W5J,6GGS,5YRN,2N83,2N7Z	Receptor-interacting serine/threonine-protein kinase 2	RIPK2_HUMAN	O43353	B7Z748 Q6UWF0