BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1574749 O=c1[nH]nc2c3c(cc(F)cc13)N[C@H](C1(F)CC1)[C@H]2c1ccccc1Cl 786949 US20250346599, Compound 0260A Poly [ADP-ribose] polymerase 1 Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786949&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574750 C[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1c1ccc(C#N)cc1F 786950 US20250346599, Compound 0194A Poly [ADP-ribose] polymerase 1 Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786950&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574751 CC(C)[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1c1c(F)cc(F)cc1F 786951 US20250346599, Compound 0221A Poly [ADP-ribose] polymerase 1 Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786951&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574752 O=c1[nH]nc2c3c(cc(F)cc13)NC(C1(F)CC1)C2c1ccc(Cl)cc1F 786952 US20250346599, Compound 0255-6 Poly [ADP-ribose] polymerase 1 Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786952&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574753 O=c1[nH]nc2c3c(cc(F)cc13)NC(C1CCN(C3CCC(F)(F)CC3)CC1)C2c1ccc(F)cc1F 786953 US20250346599, Compound 0271-6 Poly [ADP-ribose] polymerase 1 Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786953&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574754 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H](C1(F)CC1)[C@@H]2c1ccc(Cl)cc1F 786954 US20250346599, Compound 0255A Poly [ADP-ribose] polymerase 1 Homo sapiens 4.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786954&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574755 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H](C1CC1)[C@@H]2c1ccccc1Cl 786955 US20250346599, Compound 0207B Poly [ADP-ribose] polymerase 1 Homo sapiens 6.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786955&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574756 CC[C@@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@H]1c1ccccc1Cl 786956 US20250346599, Compound 0206B Poly [ADP-ribose] polymerase 1 Homo sapiens 6.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786956&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574757 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H](C1CCN(C3CCC(F)(F)CC3)CC1)[C@@H]2c1ccc(F)cc1F 786957 US20250346599, Compound 0271B Poly [ADP-ribose] polymerase 1 Homo sapiens 7.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786957&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574758 O=c1[nH]nc2c3c(cc(F)cc13)N[C@H](CF)[C@H]2c1ccc(Cl)cc1F 786958 US20250346599, Compound 0252B Poly [ADP-ribose] polymerase 1 Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786958&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574759 C[C@@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@H]1c1ccc(F)cc1F 786959 US20250346599, Compound 0174B Poly [ADP-ribose] polymerase 1 Homo sapiens 8.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786959&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574760 CC1Nc2cc(F)cc3c(=O)[nH]nc(c23)C1c1ccc(Cl)cc1F 786960 US20250346599, Compound 0196-5 Poly [ADP-ribose] polymerase 1 Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786960&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574761 N#Cc1ccc([C@@H]2CNc3cc(F)cc4c(=O)[nH]nc2c34)c(F)c1 786961 US20250346599, Compound 0187A Poly [ADP-ribose] polymerase 1 Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786961&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574762 CC(=O)N1CCC([C@@H]2Nc3cc(F)cc4c(=O)[nH]nc(c34)[C@H]2c2ccccc2Cl)CC1 786962 US20250346599, Compound 0223B Poly [ADP-ribose] polymerase 1 Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786962&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574763 CC[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1c1ccccc1Cl 786963 US20250346599, Compound 0206A Poly [ADP-ribose] polymerase 1 Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786963&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574764 C[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)C1c1ccc(Cl)cc1F 786964 US20250346599, Compound 0196 Poly [ADP-ribose] polymerase 1 Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786964&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574765 N#Cc1ccc([C@H]2CNc3cc(F)cc4c(=O)[nH]nc2c34)c(F)c1 786965 US20250346599, Compound 0193B Poly [ADP-ribose] polymerase 1 Homo sapiens 9.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786965&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574766 O=C1CN=C2c3c(cc(F)cc31)N[C@H]([C@H]1CCOC1)[C@H]2c1ccc(F)cc1F 786966 US20250346599, Compound 0115A Poly [ADP-ribose] polymerase 1 Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786966&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574767 C[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1c1ccccc1Cl 786967 US20250346599, Compound 0172A Poly [ADP-ribose] polymerase 1 Homo sapiens 10.00 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786967&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574768 N#Cc1ccc([C@H]2c3n[nH]c(=O)c4cc(F)cc(c34)N[C@@H]2c2c(F)cc(F)cc2F)cc1F 786968 US20250346599, Compound 0092A Poly [ADP-ribose] polymerase 1 Homo sapiens 13.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786968&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574769 N#Cc1ccc([C@@H]2c3n[nH]c(=O)c4cc(F)cc(c34)N[C@H]2c2c(F)cc(F)cc2F)cc1F 786969 US20250346599, Compound 0092B Poly [ADP-ribose] polymerase 1 Homo sapiens 13.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786969&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574770 O=c1[nH]nc2c3c(cc(F)cc13)NC(COCc1ccccc1)C2c1ccc(F)cc1F 786970 US20250346599, Compound 0267-4 Poly [ADP-ribose] polymerase 1 Homo sapiens 13.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786970&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574771 O=c1[nH]nc2c3c(cc(F)cc13)NC(C1CCC(F)(F)CC1)C2c1c(F)cc(F)cc1F 786971 US20250346599, Compound 0212A Poly [ADP-ribose] polymerase 1 Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786971&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574772 O=c1[nH]nc2c3c(cc(F)cc13)NC[C@H]2c1ccc(Cl)cc1F 786972 US20250346599, Compound 0195-5 Poly [ADP-ribose] polymerase 1 Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786972&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574773 CC(C)[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@H]1c1ccccc1Cl 786973 US20250346599, Compound 0222B Poly [ADP-ribose] polymerase 1 Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786973&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574774 C[C@@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@H]1c1ccccc1Cl 786974 US20250346599, Compound 0172B Poly [ADP-ribose] polymerase 1 Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786974&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574775 CC(C)[C@@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@H]1c1c(F)cc(F)cc1F 786975 US20250346599, Compound 0221B Poly [ADP-ribose] polymerase 1 Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786975&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574776 N#Cc1ccc([C@@H]2c3n[nH]c(=O)c4cc(F)cc(c34)N[C@H]2C2CCC(F)(F)CC2)cc1F 786976 US20250346599, Compound 0214B Poly [ADP-ribose] polymerase 1 Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786976&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574777 O=c1[nH]nc2c3c(cc(F)cc13)NC(C1CCC(F)(F)CC1)C2c1c(F)cc(F)cc1F 786971 US20250346599, Compound 0212A Poly [ADP-ribose] polymerase 1 Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786971&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574778 C[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)C1c1ccc(Cl)c(F)c1 786977 US20250346599, Compound 0195A Poly [ADP-ribose] polymerase 1 Homo sapiens 21.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786977&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574779 CN1CCCC[C@@H]1[C@H]1CNc2cc(F)cc3c(=O)[nH]nc1c23 786978 US20250346599, Compound 0192B Poly [ADP-ribose] polymerase 1 Homo sapiens 22.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786978&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574780 CC(C)[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1c1ccccc1Cl 786979 US20250346599, Compound 0222A Poly [ADP-ribose] polymerase 1 Homo sapiens 23.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786979&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574781 N#Cc1ccc([C@@H]2CNc3cc(F)cc4c(=O)[nH]nc2c34)c(F)c1 786980 US20250346599, Compound 0193A Poly [ADP-ribose] polymerase 1 Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786980&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574782 C[C@@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@H]1[C@@H]1CCCCN1C 786981 US20250346599, Compound 0199D Poly [ADP-ribose] polymerase 1 Homo sapiens 25.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786981&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574783 C[C@@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)C1c1ccc(Cl)c(F)c1 786982 US20250346599, Compound 0195B Poly [ADP-ribose] polymerase 1 Homo sapiens 26.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786982&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574784 O=c1[nH]nc2c3c(cc(F)cc13)NC[C@H]2c1ccccn1 786983 US20250346599, Compound 0211A Poly [ADP-ribose] polymerase 1 Homo sapiens 27.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786983&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574785 CN1CCCC[C@@H]1[C@@H]1CNc2cc(F)cc3c(=O)[nH]nc1c23 786984 US20250346599, Compound 0192A Poly [ADP-ribose] polymerase 1 Homo sapiens 27.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786984&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574786 C[C@@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@H]1c1ccc(Cl)c(F)c1 786985 US20250346599, Compound 0196B Poly [ADP-ribose] polymerase 1 Homo sapiens 27.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786985&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574787 O=c1[nH]nc2c3c(cc(F)cc13)NC[C@H]2c1ccc(Cl)c(F)c1 786986 US20250346599, Compound 0188A Poly [ADP-ribose] polymerase 1 Homo sapiens 28.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786986&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574788 O=c1[nH]nc2c3c(cc(F)cc13)NC[C@@H]2c1ccc(Cl)cc1F 786987 US20250346599, Compound 0189B Poly [ADP-ribose] polymerase 1 Homo sapiens 29.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786987&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574789 N#Cc1ccc([C@H]2c3n[nH]c(=O)c4cc(F)cc(c34)N[C@@H]2C2CCN(C3CCC(F)(F)CC3)CC2)c(F)c1 786988 US20250346599, Compound 0276B Poly [ADP-ribose] polymerase 1 Homo sapiens 30.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786988&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574790 O=c1[nH]nc4c2c(cc(F)cc12)N[C@@H](c3c(F)cc(F)cc3F)[C@@H]4C5CCNCC5 786989 US20250346599, Compound 0098B Poly [ADP-ribose] polymerase 1 Homo sapiens 30.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786989&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574791 O=c1[nH]nc2c3c(cc(F)cc13)N[C@H]([C@H]1CCOC1)[C@H]2c1ccccc1Cl 786990 US20250346599, Compound 0121A Poly [ADP-ribose] polymerase 1 Homo sapiens 32.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786990&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574792 O=c1[nH]nc3c2c(cc(F)cc12)NCC3c4ccc(F)cc4F 786991 US20250346599, Compound 0114-5 Poly [ADP-ribose] polymerase 1 Homo sapiens 32.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786991&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574793 CN4CCC[C@@H]([C@H]1CNc2cc(F)cc3c(=O)[nH]nc1c23)C4 786992 US20250346599, Compound 0191D Poly [ADP-ribose] polymerase 1 Homo sapiens 35.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786992&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574794 C[C@@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@H]1c1ccc(C#N)cc1F 786993 US20250346599, Compound 0194B Poly [ADP-ribose] polymerase 1 Homo sapiens 35.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786993&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574795 C[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1c1ccc(F)cc1F 786994 US20250346599, Compound 0174A Poly [ADP-ribose] polymerase 1 Homo sapiens 36.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786994&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574796 CN4CCC[C@H]([C@H]1CNc2cc(F)cc3c(=O)[nH]nc1c23)C4 786995 US20250346599, Compound 0191B Poly [ADP-ribose] polymerase 1 Homo sapiens 37.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786995&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574797 CN4CC[C@H]([C@@H]1CNc2cc(F)cc3c(=O)[nH]nc1c23)CC4 786996 US20250346599, Compound 0191A Poly [ADP-ribose] polymerase 1 Homo sapiens 37.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786996&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574798 C[C@@H]3Nc1cc(F)cc2c(=O)[nH]nc(c12)[C@@H]3[C@H]4CCCCN4C 786997 US20250346599, Compound 0199C Poly [ADP-ribose] polymerase 1 Homo sapiens 38.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786997&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574799 O=C1CN=C2c3c(cc(F)cc31)NC(C1CCOC1)C2c1ccccc1Cl 786998 US20250346599, Compound 0121-4 Poly [ADP-ribose] polymerase 1 Homo sapiens 39.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786998&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574800 C[C@H]3Nc1cc(F)cc2c(=O)[nH]nc(c12)[C@H]3[C@@H]4CCCN(C)C4 786999 US20250346599, Compound 0198B Poly [ADP-ribose] polymerase 1 Homo sapiens 39.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=786999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=786999&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574801 N#Cc1ccc([C@H]2CNc3cc(F)cc4c(=O)[nH]nc2c34)c(F)c1 787000 US20250346599, Compound 0187B Poly [ADP-ribose] polymerase 1 Homo sapiens 41.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787000&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574802 N#Cc1ccc([C@H]2CNc3cc(F)cc4c(=O)[nH]nc2c34)cc1F 787001 US20250346599, Compound 0186B Poly [ADP-ribose] polymerase 1 Homo sapiens 41.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787001&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574803 O=c1[nH]nc2c3c(cc(F)cc13)NC[C@@H]2c1ccc(F)cc1F 787002 US20250346599, Compound 0114B Poly [ADP-ribose] polymerase 1 Homo sapiens 41.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787002&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574804 O=c1[nH]nc2c3c(cc(F)cc13)NCC2c1ccc(Cl)cc1F 787003 US20250346599, Compound 0189-6 Poly [ADP-ribose] polymerase 1 Homo sapiens 41.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787003&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574805 C[C@H]3Nc1cc(F)cc2c(=O)[nH]nc(c12)[C@@H]3[C@@H]4CCCN(C)C4 787004 US20250346599, Compound 0198D Poly [ADP-ribose] polymerase 1 Homo sapiens 42.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787004&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574806 O=c1[nH]nc2c3c(cc(F)cc13)NCC2c1ccc(Cl)c(F)c1 787005 US20250346599, Compound 0188-5 Poly [ADP-ribose] polymerase 1 Homo sapiens 42.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787005&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574807 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H]([C@@H]1CCOC1)[C@@H]2c1ccccc1Cl 787006 US20250346599, Compound 0121D Poly [ADP-ribose] polymerase 1 Homo sapiens 43.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787006&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574808 C[C@@H]3Nc1cc(F)cc2c(=O)[nH]nc(c12)[C@H]3[C@H]4CCCN(C)C4 787007 US20250346599, Compound 0198C Poly [ADP-ribose] polymerase 1 Homo sapiens 45.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787007&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574809 CN1CCC([C@@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@H]2c2ccc(F)cc2F)CC1 787008 US20250346599, Compound 0110B Poly [ADP-ribose] polymerase 1 Homo sapiens 45.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787008&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574810 CN4CCC[C@H]([C@H]1CNc2cc(F)cc3c(=O)[nH]nc1c23)C4 787009 US20250346599, Compound 0191-8 Poly [ADP-ribose] polymerase 1 Homo sapiens 46.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787009&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574811 O=c1[nH]nc2c3c(cc(F)cc13)NC[C@@H]2c1ccccc1Cl 787010 US20250346599, Compound 0120B Poly [ADP-ribose] polymerase 1 Homo sapiens 47.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787010&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574812 Cc1cc(C)c([C@@H]2c3n[nH]c(=O)c4cc(F)cc(c34)N[C@H]2CC(C)(C)C)c(Cl)c1 787011 US20250346599, Compound 0219B Poly [ADP-ribose] polymerase 1 Homo sapiens 49.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787011&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574813 CN4CCC[C@H]([C@@H]1CNc2cc(F)cc3c(=O)[nH]nc1c23)C4 787012 US20250346599, Compound 0191C Poly [ADP-ribose] polymerase 1 Homo sapiens 50.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787012&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574814 COCCN1CC[C@H]([C@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@@H]2c2ccc(F)cc2F)C1 787013 US20250346599, Compound 0111A Poly [ADP-ribose] polymerase 1 Homo sapiens 51.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787013&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574815 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H](CF)[C@@H]2c1ccc(Cl)cc1F 787014 US20250346599, Compound 0252A Poly [ADP-ribose] polymerase 1 Homo sapiens 57.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787014&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574816 O=c1[nH]nc2c3c(cc(F)cc13)N[C@H](C1CC1)[C@H]2c1ccccc1Cl 787015 US20250346599, Compound 0207A Poly [ADP-ribose] polymerase 1 Homo sapiens 64.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787015&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574817 C[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1[C@H]1CCCCN1C 787016 US20250346599, Compound 0199A Poly [ADP-ribose] polymerase 1 Homo sapiens 65.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787016&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574818 O=c1[nH]nc4c2c(cc(F)cc12)NC(C3CCNC3)C4c5ccc(F)cc5F 787017 US20250346599, Compound 0173A Poly [ADP-ribose] polymerase 1 Homo sapiens 70.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787017&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574819 O=c1[nH]nc2c3c(cc(F)cc13)NC[C@H]2c1ccc(Cl)cc1F 787018 US20250346599, Compound 0189A Poly [ADP-ribose] polymerase 1 Homo sapiens 79.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787018&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574820 COCCN1CC[C@@H]([C@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@@H]2c2ccc(F)cc2F)C1 787019 US20250346599, Compound 0111B Poly [ADP-ribose] polymerase 1 Homo sapiens 80.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787019&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574821 COCCN1CC[C@H]([C@@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@H]2c2ccccc2Cl)C1 787020 US20250346599, Compound 0117C Poly [ADP-ribose] polymerase 1 Homo sapiens 85.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787020&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574822 O=c1[nH]nc2c3c(cc(F)cc13)NCC2c1ccccc1Cl 787021 US20250346599, Compound 0120 Poly [ADP-ribose] polymerase 1 Homo sapiens 87.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787021&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574823 O=c1[nH]nc2c3c(cc(F)cc13)NC(C1CCNC1)C2c1ccccc1Cl 787022 US20250346599, Compound 0171 Poly [ADP-ribose] polymerase 1 Homo sapiens 91.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787022&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574824 CN5CCC([C@H]1c3n[nH]c(=O)c4cc(F)cc(N[C@@H]1c2c(F)cc(F)cc2F)c34)CC5 787023 US20250346599, Compound 0098A Poly [ADP-ribose] polymerase 1 Homo sapiens 98.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787023&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574825 O=c1[nH]nc2c3c(cc(F)cc13)NC[C@@H]2c1ccc(Cl)c(F)c1 787024 US20250346599, Compound 0188B Poly [ADP-ribose] polymerase 1 Homo sapiens 99.0 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787024&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574826 COCCN1CC[C@H]([C@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@@H]2c2ccccc2Cl)C1 787025 US20250346599, Compound 0117A Poly [ADP-ribose] polymerase 1 Homo sapiens 101 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787025&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574827 O=c1[nH]nc2c3c(cc(F)cc13)NC(C1(F)CC1)[C@H]2c1ccc(Cl)cc1F 787026 US20250346599, Compound 0255B Poly [ADP-ribose] polymerase 1 Homo sapiens 103 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787026&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574828 O=c1[nH]nc2c3c(cc(F)cc13)NC(C1(F)CC1)[C@H]2c1ccccc1Cl 787027 US20250346599, Compound 0260B Poly [ADP-ribose] polymerase 1 Homo sapiens 106 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787027&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574829 O=c1[nH]nc2c3c(cc(F)cc13)N[C@H](C1CCOCC1)[C@H]2c1ccccc1Cl 787028 US20250346599, Compound 0210A Poly [ADP-ribose] polymerase 1 Homo sapiens 106 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787028&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574830 N#Cc1ccc([C@H]2c3n[nH]c(=O)c4cc(F)cc(c34)N[C@@H]2C2CCC(F)(F)CC2)cc1F 787029 US20250346599, Compound 0214A Poly [ADP-ribose] polymerase 1 Homo sapiens 108 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787029&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574831 C[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1[C@@H]1CCCCN1C 787030 US20250346599, Compound 0199B Poly [ADP-ribose] polymerase 1 Homo sapiens 118 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787030&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574832 COCCN1CC[C@H]([C@@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@H]2c2ccc(F)cc2F)C1 787031 US20250346599, Compound 0111C Poly [ADP-ribose] polymerase 1 Homo sapiens 120 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787031&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574833 CN1CCC([C@@H]2Nc3cc(F)cc4c(=O)[nH]nc(c34)[C@H]2c2ccccc2Cl)CC1 787032 US20250346599, Compound 0116B Poly [ADP-ribose] polymerase 1 Homo sapiens 123 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787032&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574834 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H](C1CCC(F)(F)CC1)[C@@H]2c1ccccc1Cl 787033 US20250346599, Compound 0213B Poly [ADP-ribose] polymerase 1 Homo sapiens 130 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787033&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574835 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H](C1CCOCC1)[C@@H]2c1ccccc1Cl 787034 US20250346599, Compound 0210B Poly [ADP-ribose] polymerase 1 Homo sapiens 142 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787034&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574836 COCCN1CCC(C2Nc3cc(F)cc4c3C(=NCC4=O)C2c2ccc(F)cc2F)C1 787035 US20250346599, Compound 0111-6 Poly [ADP-ribose] polymerase 1 Homo sapiens 164 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787035&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574837 O=C1CN=C2c3c(cc(F)cc31)N[C@H]([C@@H]1CCOC1)[C@H]2c1ccc(F)cc1F 787036 US20250346599, Compound 0115B Poly [ADP-ribose] polymerase 1 Homo sapiens 190 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787036&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574838 O=c1[nH]nc2c3c(cc(F)cc13)N[C@H]([C@@H]1CCOC1)[C@H]2c1ccccc1Cl 787037 US20250346599, Compound 0121B Poly [ADP-ribose] polymerase 1 Homo sapiens 236 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787037&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574839 N#Cc1ccc([C@@H]2CNc3cc(F)cc4c(=O)[nH]nc2c34)cc1F 787038 US20250346599, Compound 0186A Poly [ADP-ribose] polymerase 1 Homo sapiens 243 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787038&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574840 CC1Nc2cc(F)cc3c(=O)[nH]nc(c23)C1C1CCCN(C)C1 787039 US20250346599, Compound 0198-5 Poly [ADP-ribose] polymerase 1 Homo sapiens 244 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787039&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574841 O=C1CN=C2c3c(cc(F)cc31)N[C@@H]([C@H]1CCOC1)[C@@H]2c1ccc(F)cc1F 787040 US20250346599, Compound 0115C Poly [ADP-ribose] polymerase 1 Homo sapiens 252 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787040&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574842 O=c1[nH]nc2c3c(cc(F)cc13)NC[C@H]2c1ccc(F)cc1F 787041 US20250346599, Compound 0114A Poly [ADP-ribose] polymerase 1 Homo sapiens 270 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787041&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574843 N#Cc1ccc([C@H]2c3n[nH]c(=O)c4cc(F)cc(c34)N[C@@H]2C2CCN(C3CCC(F)(F)CC3)CC2)c(F)c1 787042 US20250346599, Compound 0276A Poly [ADP-ribose] polymerase 1 Homo sapiens 281 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787042&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574844 COCCN1CC[C@@H]([C@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@@H]2c2ccccc2Cl)C1 787043 US20250346599, Compound 0117B Poly [ADP-ribose] polymerase 1 Homo sapiens 287 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787043&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574845 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H](C1CCN(C3CCC(F)(F)CC3)CC1)[C@@H]2c1ccccc1Cl 787044 US20250346599, Compound 0261B Poly [ADP-ribose] polymerase 1 Homo sapiens 301 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787044&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574846 O=c1[nH]nc2c3c(cc(F)cc13)N[C@H](C1CCC(F)(F)CC1)[C@H]2c1ccccc1Cl 787045 US20250346599, Compound 0213A Poly [ADP-ribose] polymerase 1 Homo sapiens 352 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787045&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574847 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H](C1CCC(F)(F)CC1)[C@@H]2c1c(F)cc(F)cc1F 787046 US20250346599, Compound 0212B Poly [ADP-ribose] polymerase 1 Homo sapiens 438 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787046&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574848 Cn1ncnc1C1c2n[nH]c(=O)c3cc(F)cc(c23)NC1C1CCC(F)(F)CC1 787047 US20250346599, Compound 0215-4 Poly [ADP-ribose] polymerase 1 Homo sapiens 438 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787047&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574849 C[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1C1CCN(C)CC1 787048 US20250346599, Compound 0197A Poly [ADP-ribose] polymerase 1 Homo sapiens 447 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787048&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574850 CC(C)(C)C[C@H]1Nc2cc(F)cc3c(=O)[nH]nc(c23)[C@@H]1c1c(F)cc(F)cc1F 787049 US20250346599, Compound 0219A Poly [ADP-ribose] polymerase 1 Homo sapiens 512 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787049&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574851 COCCN1CCC(C2Nc3cc(F)cc4c3C(=NCC4=O)C2c2ccccc2Cl)C1 787050 US20250346599, Compound 0117-8 Poly [ADP-ribose] polymerase 1 Homo sapiens 566 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787050&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574852 O=c1[nH]nc2c3c(cc(F)cc13)NC(COCc1ccccc1)C2c1ccccc1Cl 787051 US20250346599, Compound 0257-4 Poly [ADP-ribose] polymerase 1 Homo sapiens 593 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787051&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574853 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H]([C@H]1CCOC1)[C@@H]2c1ccccc1Cl 787052 US20250346599, Compound 0121C Poly [ADP-ribose] polymerase 1 Homo sapiens 854 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787052&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574854 O=c1[nH]nc2c3c(cc(F)cc13)N[C@H](C1CCN(C3CCC(F)(F)CC3)CC1)[C@H]2c1ccccc1Cl 787053 US20250346599, Compound 0261A Poly [ADP-ribose] polymerase 1 Homo sapiens 896 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787053&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574855 O=c1[nH]nc2c3c(cc(F)cc13)N[C@@H](C1CCN(C3CCC(F)(F)CC3)CC1)[C@@H]2c1ccc(F)cc1F 787054 US20250346599, Compound 0271A Poly [ADP-ribose] polymerase 1 Homo sapiens 936 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787054&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574856 CC(=O)N1CCC([C@H]2Nc3cc(F)cc4c(=O)[nH]nc(c34)[C@@H]2c2ccccc2Cl)CC1 787055 US20250346599, Compound 0223A Poly [ADP-ribose] polymerase 1 Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787055&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574857 O=c1[nH]nc2c3c(cc(F)cc13)NC(C1CCCN1)C2c1ccccc1Cl 787056 US20250346599, Compound 0181-6 Poly [ADP-ribose] polymerase 1 Homo sapiens 1200 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787056&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574858 COCCN1CC[C@@H]([C@@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@H]2c2ccc(F)cc2F)C1 787057 US20250346599, Compound 0111D Poly [ADP-ribose] polymerase 1 Homo sapiens 1240 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787057&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574859 CN1CCC([C@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@@H]2c2ccc(F)cc2F)CC1 787058 US20250346599, Compound 0110A Poly [ADP-ribose] polymerase 1 Homo sapiens 1400 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787058&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574860 Cn1ncnc1[C@@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@H]1C1CCN(C2CCC(F)(F)CC2)CC1 787059 US20250346599, Compound 0266A Poly [ADP-ribose] polymerase 1 Homo sapiens 1680 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787059&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574861 COCCN1CC[C@@H]([C@@H]2Nc3cc(F)cc4c3C(=NCC4=O)[C@H]2c2ccccc2Cl)C1 787060 US20250346599, Compound 0117D Poly [ADP-ribose] polymerase 1 Homo sapiens 3080 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787060&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574862 CN1CCC([C@H]2Nc3cc(F)cc4c(=O)[nH]nc(c34)[C@@H]2c2ccccc2Cl)CC1 787061 US20250346599, Compound 0116A Poly [ADP-ribose] polymerase 1 Homo sapiens 5280 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787061&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8 1574863 Cn1ncnc1[C@H]1c2n[nH]c(=O)c3cc(F)cc(c23)N[C@@H]1C1CCN(C2CCC(F)(F)CC2)CC1 787062 US20250346599, Compound 0266B Poly [ADP-ribose] polymerase 1 Homo sapiens 5780 Curated from the literature by BindingDB n/a 11/13/2025 3/4/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=232&target=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787062&enzyme=Poly+%5BADP-ribose%5D+polymerase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW 9MJA,9MI8,4OQB,4OQA,4OPX,4DQY,8G0H,7S6M,7S6H,5A00,4ZZZ,4XHU,6XVW,5HA9,4PJT,2RCW,1WOK,1UK1,1UK0,6I8T,6I8M,7S81,7S68,6M3I,9DMC,9BPY,8FZ1,8FYZ,8FYY,6NTU,6NRJ,6NRI,6NRH,6NRG,6NRF,6BHV,5DS3,8U4W,2N8A,2RIQ,2JVN,2CR9,2CS2,2L31,2L30,3ODE,3ODC,7SCZ,7SCY,3ODA,3OD8,2DMJ Poly [ADP-ribose] polymerase 1 PARP1_HUMAN P09874 B1ANJ4 Q8IUZ9 N/A A0A024R3T8