BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1576367 Cc1cc(NC(=O)C(O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787621 2-amino-5-(4- (2-hydroxy-2- phenylacetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-phenylacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 1 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787621 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787621&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576368 Cc1cc(NC(=O)C(O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787637 2-amino-5-(4- (2-hydroxy-2- phenylacetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-phenylacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 2 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787637 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787637&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576369 Cc1cc(NC(=O)C(C)(O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787660 2-amino-5-(4- (2-hydroxy-2- phenylpropanamido)- 2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-phenylpropanamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 3 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787660 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787660&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576370 Cc1cc(NC(=O)C(C)(O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787661 2-amino-5-(4- (2-hydroxy-2- phenylpropanamido)- 2-methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-phenylpropanamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 4 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787661 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787661&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576371 COC(C(=O)Nc1ccc(-c2cnc(N)c(C(=O)NC(C)C)c2)c(C)c1)c1ccccc1 787679 2-amino-N- isopropyl-5-(4- (2-methoxy-2- phenylacetamido)- 2- methylphenyl) nicotinamide::2-amino-N-isopropyl-5-(4-(2-methoxy-2-phenylacetamido)-2-methylphenyl)nicotinamide::US12473296, Example 5 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787679 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787679&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576372 Cc1cc(NC(=O)C(N)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787806 2-amino-5-(4- (2-amino-2- phenylacetamido)- 2-methylphenyl)- N-isopropyl- nicotinamide::2-amino-5-(4-(2-amino-2-phenylacetamido)-2-methylphenyl)-N-isopropyl-nicotinamide::US12473296, Example 6 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787806&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576373 Cc1cc(NC(=O)C(N)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787817 2-amino-5-(4- (2-amino-2- phenylacetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-amino-2-phenylacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 7 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787817&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576374 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787818 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)-2- methylphenyl)-N- 2- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 8 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787818&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576375 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787819 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 9 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787819&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576376 CNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cnc1N 787820 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-methylphenyl)- N- methylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-methylnicotinamide::US12473296, Example 10 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787820&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576377 CNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cnc1N 787821 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N- methylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-methylnicotinamide::US12473296, Example 11 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 750.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787821&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576378 CCNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cnc1N 787822 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N- ethylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-ethylnicotinamide::US12473296, Example 12 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787822&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576379 CCNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cnc1N 787823 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N- ethylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-ethylnicotinamide::US12473296, Example 13 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787823&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576380 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)c1 787824 2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) nicotinamide::2-amino-N-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide::US12473296, Example 14 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787824&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576381 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)c1 787825 2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) nicotinamide::2-amino-N-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide::US12473296, Example 15 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787825 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787825&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576382 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)(C)C)c1 787826 2-amino-N- (tert-butyl)-5- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) nicotinamide::2-amino-N-(tert-butyl)-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide::US12473296, Example 16 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787826&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576383 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)(C)C)c1 787827 2-amino-N- (tert-butyl)-5- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) nicotinamide::2-amino-N-(tert-butyl)-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide::US12473296, Example 17 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787827&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576384 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCC(F)(F)F)c1 787828 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(2,2,2- trifluoroethyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(2,2,2-trifluoroethyl)nicotinamide::US12473296, Example 18 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787828 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787828&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576385 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCC(F)(F)F)c1 787829 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(2,2,2- trifluoroethyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(2,2,2-trifluoroethyl)nicotinamide::US12473296, Example 19 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787829&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576386 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCC(C)C)c1 787830 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N- isobutylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isobutylnicotinamide::US12473296, Example 20 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787830 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787830&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576387 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCC(C)C)c1 787831 2-amino-5-(4- (2-(3,5-difluorophenyl)- 2- hydroxyacetamido)-2- methylphenyl)- N- isobutylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isobutylnicotinamide::US12473296, Example 21 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787831&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576388 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)N(C)C)c1 787832 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N,N- dimethylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N,N-dimethylnicotinamide::US12473296, Example 22 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 750.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787832 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787832&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576389 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)N(C)C)c1 787833 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N,N- dimethylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N,N-dimethylnicotinamide::US12473296, Example 23 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] >5000 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787833 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787833&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576390 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2COC2)c1 787834 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)-2- methylphenyl)- N-(oxetan-3- yl)nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(oxetan-3-yl)nicotinamide::US12473296, Example 24 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787834&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576391 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2COC2)c1 787835 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)-2- methylphenyl)- N-(oxetan-3- yl)nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(oxetan-3-yl)nicotinamide::US12473296, Example 25 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787835 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787835&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576392 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC(O)C2)c1 787836 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(3- hydroxycyclobutyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(3-hydroxycyclobutyl)nicotinamide::US12473296, Example 26 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787836 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787836&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576393 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC(O)C2)c1 787837 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(3- hydroxycyclobutyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(3-hydroxycyclobutyl)nicotinamide::US12473296, Example 27 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787837&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576394 COC1CC(NC(=O)c2cc(-c3ccc(NC(=O)C(O)c4cc(F)cc(F)c4)cc3C)cnc2N)C1 787838 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(3- methoxycyclobutyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(3-methoxycyclobutyl)nicotinamide::US12473296, Example 28 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787838 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787838&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576395 COC1CC(NC(=O)c2cc(-c3ccc(NC(=O)C(O)c4cc(F)cc(F)c4)cc3C)cnc2N)C1 787839 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(3- methoxycyclobutyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(3-methoxycyclobutyl)nicotinamide::US12473296, Example 29 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787839 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787839&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576396 CC(=O)N1CC(NC(=O)c2cc(-c3ccc(NC(=O)C(O)c4cc(F)cc(F)c4)cc3C)cnc2N)C1 787840 N-(1- acetylazetidin- 3-yl)-2-amino- 5-(4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) nicotinamide::N-(1-acetylazetidin-3-yl)-2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide::US12473296, Example 30 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787840 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787840&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576397 CC(=O)N1CC(NC(=O)c2cc(-c3ccc(NC(=O)C(O)c4cc(F)cc(F)c4)cc3C)cnc2N)C1 787841 N-(1- acetylazetidin- 3-yl)-2-amino- 5-(4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) nicotinamide::N-(1-acetylazetidin-3-yl)-2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide::US12473296, Example 31 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787841&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576398 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2F)cnc1N 787842 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- fluorophenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-fluorophenyl)-N-isopropylnicotinamide::US12473296, Example 32 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787842&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576399 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2F)cnc1N 787843 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- fluorophenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-fluorophenyl)-N-isopropylnicotinamide::US12473296, Example 33 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787843 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787843&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576400 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)cnc1N 787844 2-amino-5-(2- chloro-4-(2- (3,5- difluorophenyl)- 2- hydroxyacetamido) phenyl)-N- isopropylnicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)phenyl)-N-isopropylnicotinamide::US12473296, Example 34 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787844 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787844&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576401 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)cnc1N 787845 2-amino-5-(2- chloro-4-(2- (3,5- difluorophenyl)- 2- hydroxyacetamido)- N- isopropylnicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)phenyl)-N-isopropylnicotinamide::US12473296, Example 35 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787845 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787845&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576402 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C(F)(F)F)cnc1N 787846 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- (trifluoromethyl) phenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-(trifluoromethyl) phenyl)-N-isopropylnicotinamide::US12473296, Example 36 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787846 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787846&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576403 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C(F)(F)F)cnc1N 787847 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- (trifluoromethyl) phenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-(trifluoromethyl) phenyl)-N-isopropylnicotinamide::US12473296, Example 37 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787847 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787847&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576404 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787848 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- ethylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-isopropylnicotinamide::US12473296, Example 38 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787848&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576405 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787849 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- ethylpehnyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-isopropylnicotinamide::US12473296, Example 39 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787849&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576406 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787850 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 40 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787850&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576407 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(O)=O InChI=1S/C21H17F2N3O4/c1-10-4-15(26-20(28)18(27)11-5-13(22)8-14(23)6-11)2-3-16(10)12-7-17(21(29)30)19(24)25-9-12/h2-9,18,27H,1H3,(H2,24,25)(H,26,28)(H,29,30) GTVXRXBVDPTLON-UHFFFAOYSA-N 50570951 CHEMBL4865268::US12473296, Example 41 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570951&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 156117898 471061096 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576408 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)OC(C)C)c1 787852 isopropyl 2- amino-5-(4-(2- (3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) nicotinate::isopropyl 2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinate::US12473296, Example 42 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787852&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576409 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)OC(C)C)c1 787853 isopropyl 2- amino-5-(4-(2- (3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) nicotinate::isopropyl 2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinate::US12473296, Example 43 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787853&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576410 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CNC2)c1 787854 2-amino-N- (azetidin-3-yl)- 5-(4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) nicotinamide::2-amino-N-(azetidin-3-yl)-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide::US12473296, Example 44 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787854&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576411 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CNC2)c1 787855 2-amino-N- (azetidin-3-yl)- 5-(4-(2-(3,5- difluorophenyl)-2- hydroxyacetamido)- 2- methylphenyl) nicotinamide::2-amino-N-(azetidin-3-yl)-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide::US12473296, Example 45 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787855&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576412 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CN(C)C2)c1 787856 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(1- methylazetidin- 3- yl)nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(1-methylazetidin-3-yl)nicotinamide::US12473296, Example 46 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787856&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576413 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CN(C)C2)c1 787857 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(1- methylazetidin- 3- yl)nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(1-methylazetidin-3-yl)nicotinamide::US12473296, Example 47 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787857&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576414 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCCO)c1 787858 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(2- hydroxyethyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(2-hydroxyethyl)nicotinamide::US12473296, Example 56 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787858 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787858&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576415 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCCO)c1 787859 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(2- hydroxyethyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(2-hydroxyethyl)nicotinamide::US12473296, Example 57 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787859&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576416 Cc1cccc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 787860 2-amino-5-(4- (2-hydroxy-2- (m- tolyl)acetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-(m-tolyl)acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 66 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787860 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787860&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576417 Cc1cccc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 787861 2-amino-5-(4- (2-hydroxy-2- (m- tolyl)acetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-(m-tolyl)acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 67 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787861 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787861&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576418 Cc1cc(NC(=O)C(O)c2cccc(Cl)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787862 2-amino-5-(4- (2-(3- chlorophenyl)- 2- hydroxyacetamido)-2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3-chlorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 68 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787862 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787862&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576419 Cc1cc(NC(=O)C(O)c2cccc(Cl)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787863 2-amino-5-(4- (2-(3- chlorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3-chlorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 69 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787863&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576420 CCc1cccc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 787864 2-amino-5-(4- (2-(3- ethylphenyl)-2- hydroxyacetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3-ethylphenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 72 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787864 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787864&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576421 CCc1cccc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 787865 2-amino-5-(4- (2-(3- ethylphenyl)-2- hydroxyacetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3-ethylphenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 73 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787865 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787865&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576422 Cc1cc(NC(=O)C(O)c2cccc3c2OCC3)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787866 2-amino-5-(4- (2-(2,3- dihydrobenzofuran- 7-yl)-2- hydroxyacetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(2,3-dihydrobenzofuran-7-yl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 74 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787866 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787866&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576423 Cc1cc(NC(=O)C(O)c2cccc3c2OCC3)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787867 2-amino-5-(4- (2-(2,3- dihydrobenzofuran- 7-yl)-2- hydroxyacetamido)- 2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(2,3-dihydrobenzofuran-7-yl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 75 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787867 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787867&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576424 Cc1cc(NC(=O)C(O)c2cccc3cnn(C)c23)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787868 2-amino-5-(4- (2-hydroxy-2- (1-methyl-1H- indazol-7- yl)acetamido)- 2-methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-(1-methyl-1H-indazol-7-yl)acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 76 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787868 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787868&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576425 Cc1cc(NC(=O)C(O)c2cccc3cnn(C)c23)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787869 2-amino-5-(4- (2-hydroxy-2- (1-methyl-1H- indazol-7- yl)acetamido)- 2-methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-(1-methyl-1H-indazol-7-yl)acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 77 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 750.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787869&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576426 Cc1nc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)cs1 787870 2-amino-5-(4- (2-hydroxy-2- (2-methylthiazol- 4-yl)acetamido)-2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-(2-methylthiazol-4-yl)acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 78 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787870 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787870&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576427 Cc1nc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)cs1 787871 2-amino-5-(4- (2-hydroxy-2- (2-methylthiazol- 4-yl)acetamido)- 2-methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-hydroxy-2-(2-methylthiazol-4-yl)acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 79 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787871 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787871&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576428 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2)cnc1N 787872 2-amino-5-(4- (2-(3,5- difluorophenyl)-2- hydroxyacetamido) phenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-isopropylnicotinamide::US12473296, Example 80 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787872&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576429 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2)cnc1N 787873 2-amino-5-(4- (2-(3,5- difluorophenyl)-2- hydroxyacetamido) phenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-isopropylnicotinamide::US12473296, Example 81 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787873 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787873&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576430 CCNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)cnc1N 787874 2-amino-5-(2- chloro-4-(2- (3,5-difluorophenyl)- 2-hydroxyacetamido) phenyl)-N- ethylnicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-ethylnicotinamide::US12473296, Example 82 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787874 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787874&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576431 CCNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)cnc1N 787875 2-amino-5-(2- chloro-4-(2- (3,5-difluorophenyl)- 2-hydroxyacetamido) phenyl)-N- ethylnicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-ethylnicotinamide::US12473296, Example 83 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787875 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787875&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576432 Nc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)cc1C(=O)NC1CC1 787876 2-amino-5-(2- chloro-4-(2- (3,5-difluorophenyl)- 2-hydroxyacetamido) phenyl)-N- cyclopropyl- nicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-cyclopropyl-nicotinamide::US12473296, Example 84 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787876 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787876&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576433 Nc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)cc1C(=O)NC1CC1 787877 2-amino-5-(2- chloro-4-(2- (3,5-difluorophenyl)- 2-hydroxyacetamido) phenyl)-N-cyclo- propylnicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-cyclo-propylnicotinamide::US12473296, Example 85 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787877&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576434 Nc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)cc1C(=O)NCC(F)(F)F 787878 2-amino-5-(2- chloro-4-(2- (3,5-difluorophenyl)- 2-hydroxyacetamido) phenyl)-N- (2,2,2-trifluoroethyl) nicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-(2,2,2-trifluoroethyl)nicotinamide::US12473296, Example 86 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787878&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576435 Nc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)cc1C(=O)NCC(F)(F)F 787879 2-amino-5-(2- chloro-4-(2- (3,5-difluorophenyl)- 2-hydroxyacetamido) phenyl)-N- (2,2,2-trifluoroethyl) nicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-(2,2,2-trifluoroethyl)nicotinamide::US12473296, Example 87 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787879&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576436 CCc1cccc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(Cl)c2)c1 787880 2-amino-5-(2- chloro-4-(2-(3- ethylphenyl)-2- hydroxyacetamido) phenyl)-N- isopropylnicotinamide::2-amino-5-(2-chloro-4-(2-(3-ethylphenyl)-2-hydroxyacetamido) phenyl)-N-isopropylnicotinamide::US12473296, Example 94 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787880&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576437 CCc1cccc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(Cl)c2)c1 787881 2-amino-5-(2- chloro-4-(2-(3- ethylphenyl)-2- hydroxyacetamido) phenyl)-N- isopropylnicotinamide::2-amino-5-(2-chloro-4-(2-(3-ethylphenyl)-2-hydroxyacetamido) phenyl)-N-isopropylnicotinamide::US12473296, Example 95 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787881&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576438 CCNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2CC)cnc1N 787882 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)-2- ethylphenyl)-N- ethylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-ethylnicotinamide::US12473296, Example 98 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787882&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576439 CCNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2CC)cnc1N 787883 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2-hydroxyacetamido)- 2-ethylphenyl)-N- ethylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-ethylnicotinamide::US12473296, Example 99 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787883 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787883&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576440 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCC(F)(F)F)c1 787884 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- ethylphenyl)-N- (2,2,2-trifluoroethyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-(2,2,2-trifluoroethyl)nicotinamide::US12473296, Example 100 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787884 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787884&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576441 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCC(F)(F)F)c1 787885 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- ethylphenyl)-N- (2,2,2- trifluoroethyl) nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-(2,2,2-trifluoroethyl)nicotinamide::US12473296, Example 101 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787885 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787885&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576442 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)c1 787886 2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)-2- ethylphenyl) nicotinamide::2-amino-N-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)nicotinamide::US12473296, Example 102 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787886&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576443 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)c1 787887 2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- ethylphenyl) nicotinamide::2-amino-N-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)nicotinamide::US12473296, Example 103 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787887&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576444 CCc1cccc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(CC)c2)c1 787888 2-amino-5-(2- ethyl-4-(2-(3- ethylphenyl)-2- hydroxyacetamido) phenyl)-N- isopropylnicotinamide::2-amino-5-(2-ethyl-4-(2-(3-ethylphenyl)-2-hydroxyacetamido) phenyl)-N-isopropylnicotinamide::US12473296, Example 106 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787888&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576445 CCc1cccc(C(O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(CC)c2)c1 787889 2-amino-5-(2- ethyl-4-(2-(3- ethylphenyl)-2- hydroxyacetamido) phenyl)-N- isopropylnicotinamide::2-amino-5-(2-ethyl-4-(2-(3-ethylphenyl)-2-hydroxyacetamido) phenyl)-N-isopropylnicotinamide::US12473296, Example 107 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787889&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576446 CCc1cc(NC(=O)C(O)c2cccc(Cl)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787890 2-amino-5-(4- (2-(3- chlorophenyl)- 2- hydroxyacetamido)- 2- ethylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3-chlorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-isopropylnicotinamide::US12473296, Example 108 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787890&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576447 CCc1cc(NC(=O)C(O)c2cccc(Cl)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787891 2-amino-5-(4- (2-(3- chlorophenyl)- 2- hydroxyacetamido)- 2- ethylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3-chlorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-isopropylnicotinamide::US12473296, Example 109 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787891&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576448 CCc1cc(NC(=O)C(O)c2cccc(C(F)(F)F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787892 2-amino-5-(2- ethyl-4-(2- hydroxy-2-(3- (trifluoromethyl) phenyl)acetamido) phenyl)-N- isopropylnicotinamide::2-amino-5-(2-ethyl-4-(2-hydroxy-2-(3-(trifluoromethyl) phenyl)acetamido) phenyl)-N-isopropylnicotinamide::US12473296, Example 110 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787892&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576449 CCc1cc(NC(=O)C(O)c2cccc(C(F)(F)F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787893 2-amino-5-(2- ethyl-4-(2- hydroxy-2-(3- (trifluoromethyl) phenyl)acetamido) phenyl)-N- isopropylnicotinamide::2-amino-5-(2-ethyl-4-(2-hydroxy-2-(3-(trifluoromethyl) phenyl)acetamido) phenyl)-N-isopropylnicotinamide::US12473296, Example 111 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787893 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787893&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576450 COc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787894 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methoxyphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methoxyphenyl)-N-isopropylnicotinamide::US12473296, Example 112 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787894&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576451 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2OC(F)(F)F)cnc1N 787895 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- (trifluoromethoxy) phenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-(trifluoromethoxy) phenyl)-N-isopropylnicotinamide::US12473296, Example 113 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787895&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576452 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2OC(F)(F)F)cnc1N 787896 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- (trifluoromethoxy) phenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-(trifluoromethoxy) phenyl)-N-isopropylnicotinamide::US12473296, Example 114 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787896 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787896&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576453 Cc1c(-c2cnc(N)c(C(=O)NC(C)C)c2)ccc(NC(=O)C(O)c2cc(F)cc(F)c2)c1F 787897 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 3-fluoro-2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluoro-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 115 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787897 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787897&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576454 Cc1c(-c2cnc(N)c(C(=O)NC(C)C)c2)ccc(NC(=O)C(O)c2cc(F)cc(F)c2)c1F 787898 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 3-fluoro-2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluoro-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 116 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787898&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576455 CCNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)c(F)c2C)cnc1N 787899 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 3-fluoro-2- methylphenyl)- N- ethylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluoro-2-methylphenyl)-N-ethylnicotinamide::US12473296, Example 117 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787899&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576456 CCNC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)c(F)c2C)cnc1N 787900 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 3-fluoro-2- methylphenyl)- N- ethylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluoro-2-methylphenyl)-N-ethylnicotinamide::US12473296, Example 118 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787900&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576457 Cc1c(-c2cnc(N)c(C(=O)NC3CC3)c2)ccc(NC(=O)C(O)c2cc(F)cc(F)c2)c1F 787901 2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 3-fluoro-2- methylphenyl) nicotinamide::2-amino-N-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluoro-2-methylphenyl)nicotinamide::US12473296, Example 119 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787901&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576458 Cc1c(-c2cnc(N)c(C(=O)NC3CC3)c2)ccc(NC(=O)C(O)c2cc(F)cc(F)c2)c1F 787902 2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 3-fluoro-2- methylphenyl) nicotinamide::2-amino-N-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluoro-2-methylphenyl)nicotinamide::US12473296, Example 120 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787902&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576459 Cc1c(-c2cnc(N)c(C(=O)NC3COC3)c2)ccc(NC(=O)C(O)c2cc(F)cc(F)c2)c1F 787903 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 3-fluoro-2- methylphenyl)- N-(oxetan-3- yl)nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluoro-2-methylphenyl)-N-(oxetan-3-yl)nicotinamide::US12473296, Example 121 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787903&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576460 Cc1c(-c2cnc(N)c(C(=O)NC3COC3)c2)ccc(NC(=O)C(O)c2cc(F)cc(F)c2)c1F 787904 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 3-fluoro-2- methylphenyl)- N-(oxetan-3- yl)nicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluoro-2-methylphenyl)-N-(oxetan-3-yl)nicotinamide::US12473296, Example 122 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787904&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576461 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)c(F)c2Cl)cnc1N 787905 2-amino-5-(2- chloro-4-(2- (3,5- difluorophenyl)- 2- hydroxyacetamido)- 3- fluorophenyl)- N- isopropylnicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluorophenyl)-N-isopropylnicotinamide::US12473296, Example 123 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787905&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576462 CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)c(F)c2Cl)cnc1N 787906 2-amino-5-(2- chloro-4-(2- (3,5- diflouorophenyl)- 2- hydroxyacetamido)- 3- fluorophenyl)- N- isopropylnicotinamide::2-amino-5-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-3-fluorophenyl)-N-isopropylnicotinamide::US12473296, Example 124 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787906 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787906&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576463 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)c(F)cc1-c1cnc(N)c(C(=O)NC(C)C)c1 787907 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 5-fluoro-2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-5-fluoro-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 125 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787907&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576464 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)c(F)cc1-c1cnc(N)c(C(=O)NC(C)C)c1 787908 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 5-fluoro-2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-5-fluoro-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 126 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787908&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576465 Cc1cc(NC(=O)C(O)c2cccc(C(F)(F)F)c2)ncc1-c1cnc(N)c(C(=O)NC(C)C)c1 787909 6-amino-6'-(2- hydroxy-2-(3- (trifluoromethyl) phenyl)acetamido)- N- isopropyl-4'- methyl-[3,3'- bipyridine]-5- carboxamide::6-amino-6'-(2-hydroxy-2-(3-(trifluoromethyl) phenyl)acetamido)-N-isopropyl-4'-methyl-[3,3'-bipyridine]-5-carboxamide::US12473296, Example 127 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787909&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576466 Cc1cc(NC(=O)C(O)c2cccc(C(F)(F)F)c2)ncc1-c1cnc(N)c(C(=O)NC(C)C)c1 787910 6-amino-6'-(2- hydroxy-2-(3- (trifluoromethyl) phenyl)acetamido)- N- isopropyl-4'- methyl-[3,3'- bipyridine]-5- carboxamide::6-amino-6'-(2-hydroxy-2-(3-(trifluoromethyl) phenyl)acetamido)-N-isopropyl-4'-methyl-[3,3'-bipyridine]-5-carboxamide::US12473296, Example 128 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787910&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576467 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)n1 787911 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N- isopropylpyrazine-2 carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylpyrazine-2 carboxamide::US12473296, Example 133 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787911&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576468 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)n1 787912 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N- isopropylpyrazine- 2- carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylpyrazine-2-carboxamide::US12473296, Example 134 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787912&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576469 CNC(=O)c1nc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cnc1N 787913 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N- methylpyrazine- 2-carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-methylpyrazine-2-carboxamide::US12473296, Example 135 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787913&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576470 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)n1 787914 3-amino-N- cyclopropyl-6- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) pyrazine-2- carboxamide::3-amino-N-cyclopropyl-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)pyrazine-2-carboxamide::US12473296, Example 138 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787914&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576471 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)n1 787915 3-amino-N- cyclopropyl-6- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl) pyrazine-2- carboxamide::3-amino-N-cyclopropyl-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)pyrazine-2-carboxamide::US12473296, Example 139 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787915&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576472 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCCN(C)C)n1 787916 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2- methylphenyl)- N-(2- (dimethylamino) ethyl)pyrazine- 2-carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-(2-(dimethylamino) ethyl)pyrazine-2-carboxamide::US12473296, Example 146 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787916&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576473 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)n1 787917 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-ethylphenyl)- N- isopropylpyrazine- 2-carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-isopropylpyrazine-2-carboxamide::US12473296, Example 151 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787917&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576474 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)n1 787918 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-ethylphenyl)-N- isopropylpyrazine- 2-carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-isopropylpyrazine-2-carboxamide::US12473296, Example 152 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787918 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787918&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576475 CCNC(=O)c1nc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2CC)cnc1N 787919 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyactamido)- 2-ethylphenyl)-N- ethylpyrazine- 2-carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-ethylpyrazine-2-carboxamide::US12473296, Example 153 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787919&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576476 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCC(F)(F)F)n1 787920 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-ethylphenyl)-N- (2,2,2-trifluoroethyl) pyrazine-2- carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-(2,2,2-trifluoroethyl)pyrazine-2-carboxamide::US12473296, Example 154 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787920&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576477 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NCC(F)(F)F)n1 787921 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-ethylphenyl)-N- (2,2,2-trifluoroethyl) pyrazine-2- carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-(2,2,2-trifluoroethyl)pyrazine-2-carboxamide::US12473296, Example 155 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787921&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576478 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)n1 787922 3-amino-N- cyclopropyl-6- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)-2- ethylphenyl)pyrazine- 2-carboxamide::3-amino-N-cyclopropyl-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)pyrazine-2-carboxamide::US12473296, Example 156 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787922&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576479 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)n1 787923 3-amino-N- cyclopropyl-6- (4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)-2- ethylphenyl) pyrazine-2- carboxamide::3-amino-N-cyclopropyl-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)pyrazine-2-carboxamide::US12473296, Example 157 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787923&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576480 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2COC2)n1 787924 3-amino-6-(4- (3-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-ethylphenyl)-N- (oxetan-3- yl)pyrazine-2- carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-(oxetan-3-yl)pyrazine-2-carboxamide::US12473296, Example 158 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787924&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576481 CCc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2COC2)n1 787925 3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxyacetamido)-2- ethylphenyl)-N- (oxetan-3- yl)pyrazine-2- carboxamide::3-amino-6-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-(oxetan-3-yl)pyrazine-2-carboxamide::US12473296, Example 159 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787925 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787925&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576482 CCc1cc(NC(=O)C(O)c2cccc(C)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)n1 787926 3-amino-6-(2- ethyl-4-(2- hydroxy-2-(m- tolyl)acetamido) phenyl)-N- isopropylpyrazine- 2-carboxamide::3-amino-6-(2-ethyl-4-(2-hydroxy-2-(m-tolyl)acetamido) phenyl)-N-isopropylpyrazine-2-carboxamide::US12473296, Example 160 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787926&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576483 CCc1cc(NC(=O)C(O)c2cccc(C)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)n1 787927 3-amino-6-(2- ethyl-4-(2- hydroxy-2-(m- tolyl)acetamido) phenyl)-N- isopropylpyrazine- 2-carboxamide::3-amino-6-(2-ethyl-4-(2-hydroxy-2-(m-tolyl)acetamido) phenyl)-N-isopropylpyrazine-2-carboxamide::US12473296, Example 161 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787927 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787927&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576484 Nc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)nc1C(=O)NCC(F)(F)F 787928 3-amino-6-(2- chloro-4-(2- (3,5- difluorophenyl)- 2- hydroxyacetamido) phenyl)-N- (2,2,2-trifluoroethyl) pyrazine-2- carboxamide::3-amino-6-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-(2,2,2-trifluoroethyl)pyrazine-2-carboxamide::US12473296, Example 164 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787928 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787928&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576485 Nc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)nc1C(=O)NCC(F)(F)F 787929 3-amino-6-(2- chloro-4-(2- (3,5- difluorophenyl)- 2- hydroxyacetamido) phenyl)-N- (2,2,2-trifluoroethyl) pyrazine-2- carboxamide::3-amino-6-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-(2,2,2-trifluoroethyl)pyrazine-2-carboxamide::US12473296, Example 165 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787929 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787929&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576486 Nc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)nc1C(=O)NC1COC1 787930 3-amino-6-(2- chloro-4-(2- (3,5- difluorophenyl)- 2- hydroxyacetamido) phenyl)-N- (oxetan-3- yl)pyrazine-2- carboxamide::3-amino-6-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-(oxetan-3-yl)pyrazine-2-carboxamide::US12473296, Example 168 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787930 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787930&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576487 Nc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2Cl)nc1C(=O)NC1COC1 787931 3-amino-6-(2- chloro-4-(2- (3,5- difluorophenyl)- 2- hydroxyacetamido) phenyl)-N-(oxetan-3- yl)pyrazine-2- carboxamide::3-amino-6-(2-chloro-4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido) phenyl)-N-(oxetan-3-yl)pyrazine-2-carboxamide::US12473296, Example 169 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787931 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787931&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576488 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1ccc(N)nc1 787932 N-(4-(6- aminopyridin-3- yl)-3- methylphenyl)- 2-(3,5- difluorophenyl)- 2-hydroxyacetamide::N-(4-(6-aminopyridin-3-yl)-3-methylphenyl)-2-(3,5-difluorophenyl)-2-hydroxyacetamide::US12473296, Example 170 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787932 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787932&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576489 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1ccc(N)nc1 787933 N-(4-(6- aminopyridin-3- yl)-3- methylphenyl)- 2-(3,5- difluorophenyl)- 2-hydroxyacetamide::N-(4-(6-aminopyridin-3-yl)-3-methylphenyl)-2-(3,5-difluorophenyl)-2-hydroxyacetamide::US12473296, Example 171 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787933&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576490 CNc1ccc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cn1 787934 2-(3,5- difluorophenyl)- 2-hydroxy-N- (3-methyl-4-(6- (methylamino) pyridin-3-yl)phenyl) acetamide::2-(3,5-difluorophenyl)-2-hydroxy-N-(3-methyl-4-(6-(methylamino) pyridin-3-yl)phenyl)acetamide::US12473296, Example 172 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787934&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576491 CNc1ccc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cn1 787935 2-(3,5- difluorophenyl)- 2-hydroxy-N- (3-methyl-4-(6- (methylamino) pyridin-3- yl)phenyl)acetamide::2-(3,5-difluorophenyl)-2-hydroxy-N-(3-methyl-4-(6-(methylamino) pyridin-3-yl)phenyl)acetamide::US12473296, Example 173 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787935&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576492 CNc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cc1C(=O)NC(C)C 787936 5-(4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)-2- methylphenyl)- N-isopropyl-2- (methylamino) nicotinamide::5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropyl-2-(methylamino)nicotinamide::US12473296, Example 174 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787936&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576493 CNc1ncc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cc1C(=O)NC(C)C 787937 5-(4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-methylphenyl)- N-isopropyl-2- (methylamino) nicotinamide::5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropyl-2-(methylamino)nicotinamide::US12473296, Example 175 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787937&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576494 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(C)c(C(=O)NC(C)C)c1 787938 5-(4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-methylphenyl)- N-isopropyl-2- methylnicotinamide::5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropyl-2-methylnicotinamide::US12473296, Example 176 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787938&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576495 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(C)c(C(=O)NC(C)C)c1 787939 5-(4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-methylphenyl)- N-isopropyl-2- methylnicotinamide::5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropyl-2-methylnicotinamide::US12473296, Example 177 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787939&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576496 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cncc(C(=O)NC(C)C)c1 787940 5-(4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-methylphenyl)- N- isopropylnicotinamide::5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 178 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787940&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576497 Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cncc(C(=O)NC(C)C)c1 787941 5-(4-(2-(3,5- difluorophenyl)- 2- hydroxyacetamido)- 2-methylphenyl)- N- isopropylnicotinamide::5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 179 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787941&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576498 Cc1ccc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cn1 787942 2-(3,5- difluorophenyl)- 2-hydroxy-N- (3-methyl-4-(6- methylpyridin- 3- yl)phenyl)acetamide::2-(3,5-difluorophenyl)-2-hydroxy-N-(3-methyl-4-(6-methylpyridin-3-yl)phenyl)acetamide::US12473296, Example 180 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787942&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576499 Cc1ccc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2C)cn1 787943 2-(3,5- difluorophenyl)- 2-hydroxy-N- (3-methyl-4-(6- methylpyridin- 3- yl)phenyl)acetamide::2-(3,5-difluorophenyl)-2-hydroxy-N-(3-methyl-4-(6-methylpyridin-3-yl)phenyl)acetamide::US12473296, Example 181 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] >5000 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787943&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576500 Cc1cc(N(O)C(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787944 2-amino-5-(4- (2-(3,5- difluorophenyl)- N,2-dihydroxy- acetamido)-2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-N,2-dihydroxy-acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 182 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787944&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576501 Cc1cc(NC(=O)C(F)(F)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787945 2-amino-5-(4- (2,2-difluoro-2- phenylacetamido)- 2-methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2,2-difluoro-2-phenylacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 183 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787945&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576502 Cc1cc(NC(=O)C(=O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787946 2-amino-5-(4- (2-(3,5- difluorophenyl)- 2-oxoacetamido)- 2-methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl)-2-oxoacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 184 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787946&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576503 Cc1cccc(CC(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)n1 787947 2-amino-N- isopropyl-5-(2- methyl-4-(2-(6- methylpyridin- 2-yl)acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(6-methylpyridin-2-yl)acetamido) phenyl)nicotinamide::US12473296, Example 185 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787947&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576504 Cc1cc(NC(=O)Cc2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787948 2-amino-5-(4- (2-(3,5- difluorophenyl) acetamido)-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3,5-difluorophenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 186 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787948&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576505 CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)Cc2ccccc2)cc1C InChI=1S/C24H26N4O2/c1-15(2)27-24(30)21-13-18(14-26-23(21)25)20-10-9-19(11-16(20)3)28-22(29)12-17-7-5-4-6-8-17/h4-11,13-15H,12H2,1-3H3,(H2,25,26)(H,27,30)(H,28,29) QXFDNMNTISNJLZ-UHFFFAOYSA-N 50570944 CHEMBL4866245::US12473296, Example 187 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570944&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 156117919 471061089 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576506 Cc1cc(NC(=O)CCc2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787950 2-amino-N- isopropyl-5-(2- methyl-4-(3- phenylpropanamido) phenyl) nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(3-phenylpropanamido) phenyl)nicotinamide::US12473296, Example 188 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787950&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576507 Cc1cc(NC(=O)Cc2ccccc2F)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787951 2-amino-5-(4-(2-(2- fluorophenyl) acetamido)-2- methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(2-fluorophenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 189 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787951&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576508 Cc1cc(NC(=O)Cc2cccc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787952 2-amino-5-(4-(2-(3- fluorophenyl) acetamido)-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3-fluorophenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 190 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787952&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576509 Cc1cc(NC(=O)Cc2ccc(F)cc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787953 2-amino-5-(4-(2-(4- fluorophenyl) acetamido)-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(4-fluorophenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 191 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787953&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576510 COc1ccccc1CC(=O)Nc1ccc(-c2cnc(N)c(C(=O)NC(C)C)c2)c(C)c1 787954 2-amino-N- isopropyl-5-(4- (2-(2- methoxyphenyl) acetamido)- 2-methylphenyl) nicotinamide::2-amino-N-isopropyl-5-(4-(2-(2-methoxyphenyl) acetamido)-2-methylphenyl)nicotinamide::US12473296, Example 192 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787954&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576511 COc1cccc(CC(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 787955 2-amino-N- isopropyl-5-(4-(2-(3- methoxyphenyl) acetamido)-2- methylphenyl) nicotinamide::2-amino-N-isopropyl-5-(4-(2-(3-methoxyphenyl) acetamido)-2-methylphenyl)nicotinamide::US12473296, Example 193 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787955&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576512 COc1ccc(CC(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)cc1 787956 2-amino-N- isopropyl-5-(4- (2-(4- methoxyphenyl) acetamido)-2- methylphenyl) nicotinamide::2-amino-N-isopropyl-5-(4-(2-(4-methoxyphenyl) acetamido)-2-methylphenyl)nicotinamide::US12473296, Example 194 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 750.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787956&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576513 Cc1ccccc1CC(=O)Nc1ccc(-c2cnc(N)c(C(=O)NC(C)C)c2)c(C)c1 787957 2-amino-N- isopropyl-5-(2- methyl-4-(2-(o- tolyl)acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(o-tolyl)acetamido) phenyl)nicotinamide::US12473296, Example 195 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787957&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576514 Cc1cccc(CC(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 787958 2-amino-N- isopropyl-5-(2- methyl-4-(2-(m- tolyl)acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(m-tolyl)acetamido) phenyl)nicotinamide::US12473296, Example 196 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787958&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576515 Cc1ccc(CC(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)cc1 787959 2-amino-N- isopropyl-5-(2- methyl-4-(2-(p- tolyl)acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(p-tolyl)acetamido) phenyl)nicotinamide::US12473296, Example 197 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787959&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576516 Cc1cc(NC(=O)Cc2ccccc2Cl)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787960 2-amino-5-(4- (2-(2-chlorophenyl) acetamido)- 2-methylphenyl)- N- isopropylnicotinamide::2-amino-5-(4-(2-(2-chlorophenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 198 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787960&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576517 Cc1cc(NC(=O)Cc2cccc(Cl)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787961 2-amino-5-(4-(2-(3- chlorophenyl) acetamido)-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3-chlorophenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 199 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787961&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576518 Cc1cc(NC(=O)Cc2ccc(Cl)cc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787962 2-amino-5-(4-(2-(4- chlorophenyl) acetamido)-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(4-chlorophenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 200 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 750.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787962&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576519 Cc1cc(NC(=O)Cc2ccccc2C(F)(F)F)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787963 2-amino-N- isopropyl-5-(2- methyl-4-(2-(2- (trifluoromethyl) phenyl)acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(2-(trifluoromethyl) phenyl)acetamido) phenyl)nicotinamide::US12473296, Example 201 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787963&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576520 Cc1cc(NC(=O)Cc2cccc(C(F)(F)F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787964 2-amino-N- isopropyl-5-(2- methyl-4-(2-(3- (trifluoromethyl) phenyl) acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(3-(trifluoromethyl) phenyl) acetamido) phenyl)nicotinamide::US12473296, Example 202 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787964&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576521 Cc1cc(NC(=O)Cc2ccc(C(F)(F)F)cc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787965 2-amino-N- isopropyl-5-(2- methyl-4-(2-(4- (trifluoromethyl) phenyl) acetamido) phenyl) nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(4-(trifluoromethyl) phenyl) acetamido) phenyl)nicotinamide::US12473296, Example 203 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 2500 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787965&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576522 CCc1ccccc1CC(=O)Nc1ccc(-c2cnc(N)c(C(=O)NC(C)C)c2)c(C)c1 787966 2-amino-5-(4-(2-(2- ethylphenyl) acetamido)-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(2-ethylphenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 204 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787966&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576523 CCc1cccc(CC(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 787967 2-amino-5-(4-(2-(3- ethylphenyl) acetamido)-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(3-ethylphenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 205 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787967&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576524 CCc1ccc(CC(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)cc1 787968 2-amino-5-(4-(2-(4- ethylphenyl) acetamido)-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-(4-ethylphenyl) acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 206 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787968&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576525 Cc1cc(NC(=O)Cc2cccc3ccccc23)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787969 2-amino-N- isopropyl-5-(2- methyl-4-(2- (naphthalen-1- yl)acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(naphthalen-1-yl)acetamido) phenyl)nicotinamide::US12473296, Example 207 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 13 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787969&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576526 Cc1cc(NC(=O)Cc2ccc3ccccc3c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787970 2-amino-N- isopropyl-5-(2- methyl-4-(2- (naphthalen-2- yl)acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(naphthalen-2-yl)acetamido) phenyl)nicotinamide::US12473296, Example 208 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 38 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787970&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576527 Cc1cc(NC(=O)Cc2ccc3ncccc3c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787971 2-amino-N- isopropyl-5-(2- methyl-4-(2- (quinolin-6- yl)acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(quinolin-6-yl)acetamido) phenyl)nicotinamide::US12473296, Example 209 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 175.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787971&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576528 Cc1cc(NC(=O)Cc2cncc3ccccc23)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787972 2-amino-N- isopropyl-5-(4- (2-(isoquinolin-4- yl)acetamido)-2- methylphenyl) nicotinamide::2-amino-N-isopropyl-5-(4-(2-(isoquinolin-4-yl)acetamido)-2-methylphenyl)nicotinamide::US12473296, Example 210 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 75.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787972&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576529 Cc1cc(NC(=O)Cc2cccc3cnccc23)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787973 2-amino-N- isopropyl-5-(4- (2-(isoquinolin-5- yl)acetamido)-2- methylphenyl) nicotinamide::2-amino-N-isopropyl-5-(4-(2-(isoquinolin-5-yl)acetamido)-2-methylphenyl)nicotinamide::US12473296, Example 211 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787973&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576530 Cc1cc(NC(=O)Cc2cccc3ncccc23)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787974 2-amino-N- isopropyl-5-(2- methyl-4-(2- (quinolin-5- yl)acetamido) phenyl)nicotinamide::2-amino-N-isopropyl-5-(2-methyl-4-(2-(quinolin-5-yl)acetamido) phenyl)nicotinamide::US12473296, Example 212 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787974&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576531 Cc1cc(NC(=O)CC2CC2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787975 2-amino-5-(4-(2- cyclopropyl- acetamido)-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-cyclopropyl-acetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 213 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787975&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576532 Cc1cc(NC(=O)CC2CCC2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787976 2-amino-5-(4-(2- cyclobutylacetamido)- 2-methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-cyclobutylacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 214 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 375.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787976&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576533 Cc1cc(NC(=O)CC2CCCC2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787977 2-amino-5-(4-(2- cyclopentylacetamido)- 2-methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-cyclopentylacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 215 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] >5000 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787977&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576534 Cc1cc(NC(=O)CC2CCCCC2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787978 2-amino-5-(4-(2- cyclohexylacetamido)- 2-methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-(2-cyclohexylacetamido)-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 216 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787978&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576535 Cc1cc(NC(=O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 787979 2-amino-5-(4- benzamido-2- methylphenyl)-N- isopropylnicotinamide::2-amino-5-(4-benzamido-2-methylphenyl)-N-isopropylnicotinamide::US12473296, Example 217 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] >5000 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=787979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=787979&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576536 CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)Nc2ccccc2)cc1C InChI=1S/C23H25N5O2/c1-14(2)26-22(29)20-12-16(13-25-21(20)24)19-10-9-18(11-15(19)3)28-23(30)27-17-7-5-4-6-8-17/h4-14H,1-3H3,(H2,24,25)(H,26,29)(H2,27,28,30) VKFZHZWJYKJRRR-UHFFFAOYSA-N 50570946 CHEMBL4853233::US12473296, Example 218 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570946&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 164614529 471061091 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9 1576537 CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)Oc2ccccc2)cc1C InChI=1S/C23H24N4O3/c1-14(2)26-22(28)20-12-16(13-25-21(20)24)19-10-9-17(11-15(19)3)27-23(29)30-18-7-5-4-6-8-18/h4-14H,1-3H3,(H2,24,25)(H,26,28)(H,27,29) HZRVZTYGGHKYBH-UHFFFAOYSA-N 50570945 CHEMBL4856844::US12473296, Example 219 Interferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116] 1500.5 Curated from the literature by BindingDB n/a 11/18/2025 3/8/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=486&target=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570945&enzyme=Interferon-induced%2C+double-stranded+RNA-activated+protein+kinase+%5B252-551%5D%2FEukaryotic+translation+initiation+factor+2-alpha+kinase+3+%5B536-1116%5D&column=ki&startPg=0&Increment=50&submit=Search 156130305 471061090 2 MKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 6D3L,6D3K,2A1A,2A19 Interferon-induced, double-stranded RNA-activated protein kinase E2AK2_HUMAN P19525 A8K3P0 D6W584 E9PC80 Q52M43 Q7Z6F6 Q9UIR4 TTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN Interferon-induced, double-stranded RNA-activated protein kinase A0A7P0TAL9_HUMAN A0A7P0TAL9